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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PPP3CA-HMGXB3 (FusionGDB2 ID:68118) |
Fusion Gene Summary for PPP3CA-HMGXB3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP3CA-HMGXB3 | Fusion gene ID: 68118 | Hgene | Tgene | Gene symbol | PPP3CA | HMGXB3 | Gene ID | 5530 | 22993 |
| Gene name | protein phosphatase 3 catalytic subunit alpha | HMG-box containing 3 | |
| Synonyms | ACCIID|CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | HMGX3|SMF | |
| Cytomap | 4q24 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | HMG domain-containing protein 3HMG box domain containing 3 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | . | Q12766 | |
| Ensembl transtripts involved in fusion gene | ENST00000507176, ENST00000323055, ENST00000394853, ENST00000394854, ENST00000512215, ENST00000523694, ENST00000510292, | ENST00000502717, ENST00000503427, | |
| Fusion gene scores | * DoF score | 25 X 13 X 8=2600 | 6 X 7 X 3=126 |
| # samples | 23 | 6 | |
| ** MAII score | log2(23/2600*10)=-3.49880585697144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/126*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP3CA [Title/Abstract] AND HMGXB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PPP3CA(102267896)-HMGXB3(149410304), # samples:1 PPP3CA(102267896)-HMGXB3(149406269), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PPP3CA-HMGXB3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
| Hgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
| Hgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
| Hgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Hgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
| Fusion gene breakpoints across PPP3CA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HMGXB3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A3UA-01A | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| ChimerDB4 | SARC | TCGA-DX-A3UA-01A | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
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Fusion Gene ORF analysis for PPP3CA-HMGXB3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000507176 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| 5UTR-3CDS | ENST00000507176 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| 5UTR-3CDS | ENST00000507176 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| 5UTR-3CDS | ENST00000507176 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| Frame-shift | ENST00000323055 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000323055 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000394853 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000394853 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000394854 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000394854 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000512215 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000512215 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000523694 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| Frame-shift | ENST00000523694 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| In-frame | ENST00000323055 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000323055 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000394853 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000394853 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000394854 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000394854 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000512215 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000512215 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000523694 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| In-frame | ENST00000523694 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| intron-3CDS | ENST00000510292 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| intron-3CDS | ENST00000510292 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| intron-3CDS | ENST00000510292 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149406269 | + |
| intron-3CDS | ENST00000510292 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000512215 | PPP3CA | chr4 | 102267896 | - | ENST00000503427 | HMGXB3 | chr5 | 149410304 | + | 3515 | 739 | 799 | 2883 | 694 |
| ENST00000512215 | PPP3CA | chr4 | 102267896 | - | ENST00000502717 | HMGXB3 | chr5 | 149410304 | + | 3515 | 739 | 799 | 2883 | 694 |
| ENST00000394854 | PPP3CA | chr4 | 102267896 | - | ENST00000503427 | HMGXB3 | chr5 | 149410304 | + | 3518 | 742 | 802 | 2886 | 694 |
| ENST00000394854 | PPP3CA | chr4 | 102267896 | - | ENST00000502717 | HMGXB3 | chr5 | 149410304 | + | 3518 | 742 | 802 | 2886 | 694 |
| ENST00000323055 | PPP3CA | chr4 | 102267896 | - | ENST00000503427 | HMGXB3 | chr5 | 149410304 | + | 3509 | 733 | 793 | 2877 | 694 |
| ENST00000323055 | PPP3CA | chr4 | 102267896 | - | ENST00000502717 | HMGXB3 | chr5 | 149410304 | + | 3509 | 733 | 793 | 2877 | 694 |
| ENST00000394853 | PPP3CA | chr4 | 102267896 | - | ENST00000503427 | HMGXB3 | chr5 | 149410304 | + | 3365 | 589 | 649 | 2733 | 694 |
| ENST00000394853 | PPP3CA | chr4 | 102267896 | - | ENST00000502717 | HMGXB3 | chr5 | 149410304 | + | 3365 | 589 | 649 | 2733 | 694 |
| ENST00000523694 | PPP3CA | chr4 | 102267896 | - | ENST00000503427 | HMGXB3 | chr5 | 149410304 | + | 2834 | 58 | 118 | 2202 | 694 |
| ENST00000523694 | PPP3CA | chr4 | 102267896 | - | ENST00000502717 | HMGXB3 | chr5 | 149410304 | + | 2834 | 58 | 118 | 2202 | 694 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000512215 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002694711 | 0.9973053 |
| ENST00000512215 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002694711 | 0.9973053 |
| ENST00000394854 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002643719 | 0.9973563 |
| ENST00000394854 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002643719 | 0.9973563 |
| ENST00000323055 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002741347 | 0.99725866 |
| ENST00000323055 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002741347 | 0.99725866 |
| ENST00000394853 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002035438 | 0.9979646 |
| ENST00000394853 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002035438 | 0.9979646 |
| ENST00000523694 | ENST00000503427 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002148235 | 0.99785185 |
| ENST00000523694 | ENST00000502717 | PPP3CA | chr4 | 102267896 | - | HMGXB3 | chr5 | 149410304 | + | 0.002148235 | 0.99785185 |
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Fusion Genomic Features for PPP3CA-HMGXB3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PPP3CA | chr4 | 102267895 | - | HMGXB3 | chr5 | 149406268 | + | 1.60E-07 | 0.9999999 |
| PPP3CA | chr4 | 102267895 | - | HMGXB3 | chr5 | 149410303 | + | 3.44E-09 | 1 |
| PPP3CA | chr4 | 102267895 | - | HMGXB3 | chr5 | 149406268 | + | 1.60E-07 | 0.9999999 |
| PPP3CA | chr4 | 102267895 | - | HMGXB3 | chr5 | 149410303 | + | 3.44E-09 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PPP3CA-HMGXB3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:102267896/chr5:149410304) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HMGXB3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | HMGXB3 | chr4:102267896 | chr5:149410304 | ENST00000502717 | 8 | 20 | 1523_1532 | 578 | 1293.0 | Compositional bias | Note=Poly-Glu |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 307_311 | 19 | 470.0 | Motif | SAPNY motif |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 307_311 | 19 | 512.0 | Motif | SAPNY motif |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 307_311 | 19 | 522.0 | Motif | SAPNY motif |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 307_311 | 19 | 290.0 | Motif | SAPNY motif |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 341_369 | 19 | 470.0 | Region | Calcineurin B binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 392_406 | 19 | 470.0 | Region | Calmodulin-binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 407_414 | 19 | 470.0 | Region | Autoinhibitory segment |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 465_487 | 19 | 470.0 | Region | Autoinhibitory domain |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 56_340 | 19 | 470.0 | Region | Catalytic |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 341_369 | 19 | 512.0 | Region | Calcineurin B binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 392_406 | 19 | 512.0 | Region | Calmodulin-binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 407_414 | 19 | 512.0 | Region | Autoinhibitory segment |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 465_487 | 19 | 512.0 | Region | Autoinhibitory domain |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 56_340 | 19 | 512.0 | Region | Catalytic |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 341_369 | 19 | 522.0 | Region | Calcineurin B binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 392_406 | 19 | 522.0 | Region | Calmodulin-binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 407_414 | 19 | 522.0 | Region | Autoinhibitory segment |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 465_487 | 19 | 522.0 | Region | Autoinhibitory domain |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 56_340 | 19 | 522.0 | Region | Catalytic |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 341_369 | 19 | 290.0 | Region | Calcineurin B binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 392_406 | 19 | 290.0 | Region | Calmodulin-binding |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 407_414 | 19 | 290.0 | Region | Autoinhibitory segment |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 465_487 | 19 | 290.0 | Region | Autoinhibitory domain |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 56_340 | 19 | 290.0 | Region | Catalytic |
| Tgene | HMGXB3 | chr4:102267896 | chr5:149410304 | ENST00000502717 | 8 | 20 | 276_282 | 578 | 1293.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | HMGXB3 | chr4:102267896 | chr5:149410304 | ENST00000502717 | 8 | 20 | 518_524 | 578 | 1293.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | HMGXB3 | chr4:102267896 | chr5:149410304 | ENST00000502717 | 8 | 20 | 62_239 | 578 | 1293.0 | Compositional bias | Note=Arg-rich | |
| Tgene | HMGXB3 | chr4:102267896 | chr5:149410304 | ENST00000502717 | 8 | 20 | 288_356 | 578 | 1293.0 | DNA binding | HMG box |
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Fusion Gene Sequence for PPP3CA-HMGXB3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >68118_68118_1_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000323055_HMGXB3_chr5_149410304_ENST00000502717_length(transcript)=3509nt_BP=733nt AGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGCTCTGTG TGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCC AAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCG TGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTT CCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGG CTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCC TAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGC AGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGAC AGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAA GTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACAC CAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAG CTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCG CAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTATCTTGTC CAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAG CCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCA GGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCT GGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGT GCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCT CACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCT AGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGAGACAGA GGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAG AGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCA GGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGC AGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCA CTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCA TGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTA CCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCT CTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCA TGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAACCATCCT GGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTACAACCGCCT CATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGA CACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGC CAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGT CTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAAC CCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTG AGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCA CTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCT TTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCT >68118_68118_1_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000323055_HMGXB3_chr5_149410304_ENST00000502717_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_2_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000323055_HMGXB3_chr5_149410304_ENST00000503427_length(transcript)=3509nt_BP=733nt AGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGCTCTGTG TGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCC AAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCG TGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTT CCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGG CTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCC TAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGC AGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGAC AGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAA GTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACAC CAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAG CTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCG CAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTATCTTGTC CAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAG CCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCA GGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCT GGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGT GCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCT CACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCT AGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGAGACAGA GGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAG AGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCA GGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGC AGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCA CTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCA TGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTA CCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCT CTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCA TGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAACCATCCT GGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTACAACCGCCT CATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGA CACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGC CAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGT CTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAAC CCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTG AGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCA CTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCT TTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCT >68118_68118_2_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000323055_HMGXB3_chr5_149410304_ENST00000503427_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_3_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394853_HMGXB3_chr5_149410304_ENST00000502717_length(transcript)=3365nt_BP=589nt AGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCC CGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGG GTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAAC CACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCG CGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCG TTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAG CCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGT TGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGG AAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGA CCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAG GGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTT GATTCATGAACTCAACAGCTCTCGACTTATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTA TGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCT GCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACAT CTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGA CCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGA GCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAA AGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGT AAATGTGGAGGACTTTTGGGCCACGATGGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGC GTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGT ACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCA GCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGT ACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTC CAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATAT GGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCC CACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCA CCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGC CCTGTGCCCTGAATTGGCACCTTACGCAACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTT CGACAATGCCACTCACTATTACCTCTACAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGT ACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGG TGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCC TGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCC TGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCAC TTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGT GGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAG CCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTG ATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAG >68118_68118_3_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394853_HMGXB3_chr5_149410304_ENST00000502717_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_4_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394853_HMGXB3_chr5_149410304_ENST00000503427_length(transcript)=3365nt_BP=589nt AGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCC CGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGG GTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAAC CACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCG CGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCG TTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAG CCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGT TGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGG AAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGA CCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAG GGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTT GATTCATGAACTCAACAGCTCTCGACTTATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTA TGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCT GCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACAT CTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGA CCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGA GCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAA AGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGT AAATGTGGAGGACTTTTGGGCCACGATGGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGC GTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGT ACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCA GCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGT ACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTC CAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATAT GGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCC CACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCA CCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGC CCTGTGCCCTGAATTGGCACCTTACGCAACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTT CGACAATGCCACTCACTATTACCTCTACAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGT ACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGG TGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCC TGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCC TGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCAC TTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGT GGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAG CCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTG ATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAG >68118_68118_4_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394853_HMGXB3_chr5_149410304_ENST00000503427_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_5_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394854_HMGXB3_chr5_149410304_ENST00000502717_length(transcript)=3518nt_BP=742nt GGTGAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGG CGCTCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCC GGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAA TCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCC ATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAG TCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAG CTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTC GGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCG ACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCC TCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTA TGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTAT CGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCA GCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACT TATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCT CTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGT GACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAA CAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCT GAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTT TGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGA GAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGAT GGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACC ACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAG GCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCC CTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCC CCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGC CCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGA CCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTG CCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCG CATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGC AACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTA CAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGT CATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGC AGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGC AGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCA GTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAG GGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGA GCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGC CTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTC TCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAGCTCTCTTCCAGCACTGTCCTCTCCACC >68118_68118_5_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394854_HMGXB3_chr5_149410304_ENST00000502717_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_6_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394854_HMGXB3_chr5_149410304_ENST00000503427_length(transcript)=3518nt_BP=742nt GGTGAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGG CGCTCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCC GGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAA TCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCC ATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAG TCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAG CTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTC GGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCG ACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCC TCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTA TGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTAT CGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCA GCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACT TATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCT CTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGT GACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAA CAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCT GAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTT TGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGA GAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGAT GGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACC ACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAG GCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCC CTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCC CCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGC CCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGA CCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTG CCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCG CATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGC AACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTA CAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGT CATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGC AGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGC AGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCA GTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAG GGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGA GCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGC CTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTC TCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAGCTCTCTTCCAGCACTGTCCTCTCCACC >68118_68118_6_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000394854_HMGXB3_chr5_149410304_ENST00000503427_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_7_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000512215_HMGXB3_chr5_149410304_ENST00000502717_length(transcript)=3515nt_BP=739nt GAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGC TCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGG GACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCC TGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATC CCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCG GCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTC AGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGG GTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACG ACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCC ATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGT CTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGA GGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCT GCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTAT CTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTG TAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGAC TGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAA GCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAA GTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGA GTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAA TGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGA GACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACT CATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCT GCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTT TGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCC ACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCG TGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCT CTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCC AGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCAT CGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAAC CATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTACAA CCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCAT TCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGA ATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGA AGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTT CTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGG AGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCC CCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTG TTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCT CTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAGCTCTCTTCCAGCACTGTCCTCTCCACCCCA >68118_68118_7_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000512215_HMGXB3_chr5_149410304_ENST00000502717_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_8_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000512215_HMGXB3_chr5_149410304_ENST00000503427_length(transcript)=3515nt_BP=739nt GAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGC TCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGG GACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCC TGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATC CCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCG GCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTC AGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGG GTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACG ACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCAGGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCC ATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAGAGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGT CTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCTTGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGA GGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCACAGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCT GCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGTCTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTAT CTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTCGAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTG TAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGAGTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGAC TGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTTCATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAA GCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCTCGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAA GTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCAGCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGA GTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGTGGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAA TGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTCTAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGA GACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAAATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACT CATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGTGCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCT GCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGAGAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTT TGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTACGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCC ACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGTCTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCG TGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGTGGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCT CTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTTCTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCC AGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTCTATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCAT CGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCACTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAAC CATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCCCATTGCCTTCGACAATGCCACTCACTATTACCTCTACAA CCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCATGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCAT TCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGAGGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGA ATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAGGCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGA AGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCTTCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTT CTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCGAGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGG AGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTGGGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCC CCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCCTGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTG TTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTTGGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCT CTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGTCAGCCACAGCTCTCTTCCAGCACTGTCCTCTCCACCCCA >68118_68118_8_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000512215_HMGXB3_chr5_149410304_ENST00000503427_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_9_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000523694_HMGXB3_chr5_149410304_ENST00000502717_length(transcript)=2834nt_BP=58nt ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCA GGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAG AGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCT TGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCAC AGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGT CTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTC GAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGA GTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTT CATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCT CGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCA GCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGT GGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTC TAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAA ATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGT GCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGA GAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTA CGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGT CTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGT GGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTT CTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTC TATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCA CTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCC CATTGCCTTCGACAATGCCACTCACTATTACCTCTACAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCA TGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGA GGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAG GCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCT TCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCG AGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTG GGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCC TGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTT GGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGT >68118_68118_9_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000523694_HMGXB3_chr5_149410304_ENST00000502717_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- >68118_68118_10_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000523694_HMGXB3_chr5_149410304_ENST00000503427_length(transcript)=2834nt_BP=58nt ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTACCAAGTGGCCCATCCAACAGGACTTCTCA GGTGAAAGTTGTGGAGGTCAAGCCCGATATGTTTCCTCCATATAAGTACAGCTGCACTGTCACATTGGATTTGGGCCTGGCTACATCAAG AGGCCGGGGAAAGTGCAAGAATCCCTCTTGTAGCTATGTCTACACCAACAGGCACAAACCTCGAATTTGTCCCAGCTGTGGTGTTAACCT TGCCAAAGACCGGACTGAGAAAACCACCAAGGCTATCGAGGTGAGCTCACCACTCCCAGATGTACTGAATGCCACAGAGCCCCTGAGCAC AGCCCAGAGGGAGATCCAGCGCCAGTCCACACTGCAGCTGCTGCGCAAAGTCCTGCAGATTCCTGAGAATGAGTCAGAGCTGGCTGAGGT CTTCGCCTTGATTCATGAACTCAACAGCTCTCGACTTATCTTGTCCAACGTGAGTGAGGAGACAGTCACCATCGAGCAAACCTCTTGGTC GAATTATTATGAGTCTCCGTCCACGCAGTGCCTTCTCTGTAGCAGCCCATTATTCAAAGGGGGACAAAACTCCCTGGCTGGGCCCCAGGA GTGCTGGCTGCTGACAGCCAGCCGTCTGCAGACAGTGACTGCCCAGGTGAAGATGTGTCTGAACCCCCATTGTCTGGCCCTGCACAGCTT CATAGACATCTACACAGGTCTCTTTAATGTGGGGAACAAGCTGCTGGTAAGCCTGGACTTGCTTTTTGCAATCAGAAATCAGATCAAGCT CGGAGAGGACCCCAGAGTGTCCATCAATGTTGTTCTGAAGTCGGTGCAGGAGCAGACAGAGAAGACTCTGACCTCGGAGGAGCTGAGCCA GCTGCAGGAGCTGCTGTGCAATGGCTATTGGGCCTTTGAGTGCCTCACTGTCCGAGACTACAATGACATGATCTGTGGCATCTGTGGTGT GGCCCCCAAAGTGGAAATGGCTCAGAGGAGTGAAGAGAATGTGCTAGCACTGAAGAGCGTGGAGTTCACCTGGCCTGAATTCCTGGGCTC TAATGAGGTAAATGTGGAGGACTTTTGGGCCACGATGGAGACAGAGGTGATTGAGCAGGTGGCATTTCCTGCCAGCATCCCTATCACCAA ATTTGATGCGTCTGTTATTGCCCCCTTCTTCCCACCACTCATGAGAGGAGCTGTGGTCGTCAACACTGAGAAAGACAAAAACCTGGATGT GCAGCCAGTACCTGGCAGTGGCAGTGCCTTGGTGAGGCTGCTCCAGGAGGGCACCTGCAAGCTTGATGAGATTGGCTCCTACAGTGAAGA GAAGCTGCAGCACCTGCTAAGGCAGTGTGGAATCCCCTTTGGGGCAGAAGACTCCAAGGACCAGCTCTGCTTCTCCTTGTTGGCCCTCTA CGAATCTGTACAGAATGGAGCTAGAGCTATACGGCCCCCACGTCACTTCACAGGTGGTAAAATCTACAAGGTGTGCCCCCATCAGGTGGT CTGCGGCTCCAAGTATCTTGTGCGAGGTGAGAGTGCCCGTGACCATGTGGACCTGCTTGCCTCTTCCCGCCACTGGCCGCCTGTCTATGT GGTAGATATGGCCACGTCAGTGGCCCTGTGTGCTGACCTCTGCTACCCAGAGCTGACTAACCAGATGTGGGGGAGGAACCAGGGCTGTTT CTCTAGCCCCACAGAGCCACCTGTGAGTGTGTCCTGCCCAGAGCTCTTGGACCAGCATTATACTGTGGACATGACAGAAACTGAGCACTC TATCCAGCACCCAGTCACCAAGACTGCCACGCGGCGCATCGTCCATGCAGGCCTACAGCCCAATCCTGGTGACCCCAGTGCTGGGCACCA CTCCTTGGCCCTGTGCCCTGAATTGGCACCTTACGCAACCATCCTGGCCTCCATCGTGGACAGCAAACCAAACGGTGTCCGCCAGCGGCC CATTGCCTTCGACAATGCCACTCACTATTACCTCTACAACCGCCTCATGGACTTCCTCACCAGCCGCGAAATTGTCAATCGTCAGATCCA TGACATTGTACAGAGCTGCCAGCCTGGTGAGGTGGTCATTCGTGACACCCTCTACCGCCTTGGGGTTGCTCAGATCAAGACAGAGACAGA GGAGGAGGGTGAGGAAGAGGAGGTGGCCGCAGTGGCAGAATAAGCCAGGCTGTTGTACAGGGACTACACCATCTCTCAAGCCATAGTAAG GCCCTTGCCTGAGGCAGAGCTATCCAGGGGACCTGCAGAAGTGGTCTCCTGTGGGGAGGGCCTCTGACTGCTGGGACTGACCAAAGAGCT TCCATTCCCTGAGCATGGTGGGACCCAGGGTCCTCAGTTCTCAACCCTCCAGGGGTCAGGAGTGGTACCAGGAAACCTCTTCTGGCCCCG AGAGAGCACTTGGGGGACACGGTATGTTTAATGGAGGGGAGGCTGAGGGAAAGGCTCGTAGCTGGTGGGTTCCGTGGGGCCTGCGGTGTG GGTCAGGGTGGAGGTCCTGGGTGGGCTAAGGCGTGAGCCCCAGCACTAGGTGGGAAGGCTGCTGAGGTCTCTCCCACCCCTGAGGAGCCC TGGTTTCAGCCCCCTCAGTCTGATGAATTGCTTAGCCTGTTGCCTTTGACTAGGGGCCTGGGTGGCCTCATTAACTCTAGGGGTCCCTTT GGGCTCTTGATTCTCCCTGAAGGAGGGATGCATTTCTCTCTTGCTCTTCCTGTACCCACATTTGGGGGAAGCTGAGGAGGGAGGAACAGT >68118_68118_10_PPP3CA-HMGXB3_PPP3CA_chr4_102267896_ENST00000523694_HMGXB3_chr5_149410304_ENST00000503427_length(amino acids)=694AA_BP= MFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQS TLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRL QTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGY WAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPF FPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARA IRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVS VSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PPP3CA-HMGXB3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000323055 | - | 1 | 12 | 327_336 | 19.333333333333332 | 470.0 | PxIxIF motif in substrate |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394853 | - | 1 | 13 | 327_336 | 19.333333333333332 | 512.0 | PxIxIF motif in substrate |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000394854 | - | 1 | 14 | 327_336 | 19.333333333333332 | 522.0 | PxIxIF motif in substrate |
| Hgene | PPP3CA | chr4:102267896 | chr5:149410304 | ENST00000512215 | - | 1 | 8 | 327_336 | 19.333333333333332 | 290.0 | PxIxIF motif in substrate |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PPP3CA-HMGXB3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PPP3CA-HMGXB3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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