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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP3CA-SLC39A8 (FusionGDB2 ID:68132)

Fusion Gene Summary for PPP3CA-SLC39A8

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3CA-SLC39A8
Fusion gene ID: 68132
HgeneTgene
Gene symbol

PPP3CA

SLC39A8

Gene ID

5530

64116

Gene nameprotein phosphatase 3 catalytic subunit alphasolute carrier family 39 member 8
SynonymsACCIID|CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2BBIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8
Cytomap

4q24

4q24

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 (zinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpo
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000323055, ENST00000394853, 
ENST00000394854, ENST00000507176, 
ENST00000523694, ENST00000510292, 
ENST00000512215, 		ENST00000510255, 
ENST00000356736, ENST00000424970, 
ENST00000394833, 
Fusion gene scores* DoF score25 X 13 X 8=26006 X 6 X 3=108
# samples 236
** MAII scorelog2(23/2600*10)=-3.49880585697144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP3CA [Title/Abstract] AND SLC39A8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP3CA(102014932)-SLC39A8(103184350), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP3CA-SLC39A8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3CA

GO:0006470

protein dephosphorylation

18815128|19154138

HgenePPP3CA

GO:0033173

calcineurin-NFAT signaling cascade

19154138|22688515

HgenePPP3CA

GO:0035690

cellular response to drug

11005320

HgenePPP3CA

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515

HgenePPP3CA

GO:0051592

response to calcium ion

18815128

TgeneSLC39A8

GO:0006882

cellular zinc ion homeostasis

19401385

TgeneSLC39A8

GO:0071577

zinc ion transmembrane transport

19401385

TgeneSLC39A8

GO:0097080

plasma membrane selenite transport

27166256

TgeneSLC39A8

GO:0098711

iron ion import across plasma membrane

22898811


check buttonFusion gene breakpoints across PPP3CA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC39A8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-56-8201-11APPP3CAchr4

102014932

-SLC39A8chr4

103184350

-


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Fusion Gene ORF analysis for PPP3CA-SLC39A8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000323055ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
5CDS-intronENST00000394853ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
5CDS-intronENST00000394854ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
5CDS-intronENST00000507176ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
5CDS-intronENST00000523694ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000323055ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000323055ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000394853ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000394853ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000394854ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000394854ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000507176ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000507176ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000523694ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
Frame-shiftENST00000523694ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
In-frameENST00000323055ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
In-frameENST00000394853ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
In-frameENST00000394854ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
In-frameENST00000507176ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
In-frameENST00000523694ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000510292ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000510292ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000510292ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000512215ENST00000356736PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000512215ENST00000394833PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-3CDSENST00000512215ENST00000424970PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-intronENST00000510292ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-
intron-intronENST00000512215ENST00000510255PPP3CAchr4

102014932

-SLC39A8chr4

103184350

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394854PPP3CAchr4102014932-ENST00000394833SLC39A8chr4103184350-299414666031478291
ENST00000323055PPP3CAchr4102014932-ENST00000394833SLC39A8chr4103184350-298514575941469291
ENST00000394853PPP3CAchr4102014932-ENST00000394833SLC39A8chr4103184350-284113134501325291
ENST00000507176PPP3CAchr4102014932-ENST00000394833SLC39A8chr4103184350-215562740639199
ENST00000523694PPP3CAchr4102014932-ENST00000394833SLC39A8chr4103184350-21095810593197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394854ENST00000394833PPP3CAchr4102014932-SLC39A8chr4103184350-0.0006932790.9993067
ENST00000323055ENST00000394833PPP3CAchr4102014932-SLC39A8chr4103184350-0.0006840660.999316
ENST00000394853ENST00000394833PPP3CAchr4102014932-SLC39A8chr4103184350-0.0007305210.9992694
ENST00000507176ENST00000394833PPP3CAchr4102014932-SLC39A8chr4103184350-0.0015488720.9984511
ENST00000523694ENST00000394833PPP3CAchr4102014932-SLC39A8chr4103184350-0.0009297280.99907035

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Fusion Genomic Features for PPP3CA-SLC39A8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3CA-SLC39A8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:102014932/chr4:103184350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679410_429411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679451_460411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368410_429411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368451_460411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711410_429411445.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711451_460411445.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679430_450411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368430_450411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711430_450411445.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612307_311260470.0MotifSAPNY motif
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613307_311260512.0MotifSAPNY motif
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614307_311260522.0MotifSAPNY motif
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18307_3110290.0MotifSAPNY motif
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612341_369260470.0RegionCalcineurin B binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612392_406260470.0RegionCalmodulin-binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612407_414260470.0RegionAutoinhibitory segment
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612465_487260470.0RegionAutoinhibitory domain
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-61256_340260470.0RegionCatalytic
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613341_369260512.0RegionCalcineurin B binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613392_406260512.0RegionCalmodulin-binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613407_414260512.0RegionAutoinhibitory segment
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613465_487260512.0RegionAutoinhibitory domain
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-61356_340260512.0RegionCatalytic
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614341_369260522.0RegionCalcineurin B binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614392_406260522.0RegionCalmodulin-binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614407_414260522.0RegionAutoinhibitory segment
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614465_487260522.0RegionAutoinhibitory domain
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-61456_340260522.0RegionCatalytic
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18341_3690290.0RegionCalcineurin B binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18392_4060290.0RegionCalmodulin-binding
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18407_4140290.0RegionAutoinhibitory segment
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18465_4870290.0RegionAutoinhibitory domain
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-1856_3400290.0RegionCatalytic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679343_348411461.0MotifXEXPHE-motif
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368343_348411461.0MotifXEXPHE-motif
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711343_348411445.0MotifXEXPHE-motif
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679154_160411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679182_191411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679213_365411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST000003567367923_132411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679387_388411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368154_160411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368182_191411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368213_365411461.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST000003948336823_132411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368387_388411461.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711154_160411445.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711182_191411445.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711213_365411445.0Topological domainCytoplasmic
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000042497071123_132411445.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711387_388411445.0Topological domainExtracellular
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679133_153411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679161_181411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679192_212411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679366_386411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000035673679389_409411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368133_153411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368161_181411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368192_212411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368366_386411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST0000039483368389_409411461.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711133_153411445.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711161_181411445.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711192_212411445.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711366_386411445.0TransmembraneHelical
TgeneSLC39A8chr4:102014932chr4:103184350ENST00000424970711389_409411445.0TransmembraneHelical


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Fusion Gene Sequence for PPP3CA-SLC39A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68132_68132_1_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000323055_SLC39A8_chr4_103184350_ENST00000394833_length(transcript)=2985nt_BP=1457nt
AGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGGCGCTCTGTG
TGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCC
AAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCG
TGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTT
CCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGG
CTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCC
TAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGC
AGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGAC
AGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGTGTGGATATC
TTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAA
AAAAATTTGCTGGATATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAGCTCTTTGAAGTCGGG
GGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTTGACAGAGGGTACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCC
TTGAAAATTCTCTACCCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTCACATTTAAACAAGAA
TGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGATGCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTC
CTGTGTGTGCATGGTGGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAACCACCTGCATATGGA
CCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGAAATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGG
TGTTCATACTTCTACAGTTTCCAGAGATGAATGATATGCTGAGAGAAAAGGTAACTGGAAGAAAAACCGATTTCACCTTCTTCATGATTC
AGAATGCTGGAATGTTAACTGGATTCACAGCCATTCTACTCATTACCTTGTATGCAGGAGAAATCGAATTGGAGTAATAGAAAATGGAAG
ATGGTGTTGTTAATAAAGGCATTTAATAGATAAAAACATCTCCAAAAAGGATTTTGAAGCTGATCCTATTTAGTTAAAAAGATAATTTTG
CTTTCAACTGTAGGTCCAGAAAACTAATTATTGGCATCAGTCTGTGAAATAGTCCATTATTTGTTGTTAAAAATGCTTCAAAAGGTTTTC
AGTGTCAGTCTGAGATGCCTGGTATATAGGAGCCTTTGGGAAATACCTATTTTTCAGTATTCCATGCATATTAGATATCACCATGAAGCA
AGAGACATGCATTCTATAATCATGTAGACACTCAGACTCAGGGGAAAATACAAGTTATATCCTGAAAGCCTTTAAAACTCTATGGTAGGA
TCAAAGATTCAAATGGTTTCAGAGAGGTTTTATTTCAATTAATTTGTTCTAGTGCTTTCAAGAGCAAGTACATCAAAATGTAGAAGGTAA
AATGTATGCAACACTAATATAAATTATTCCAAGTCTTTAAGGAGCCAAAGAAAAAAAAGATTTCTCACAGCTTTTTGTTCTGTTTTGTAT
TTCAATTAGGAACTTGCAGTATTATTTTGAAAACCATTCTAAAATAATAGGAGTTAGGAAATAAATAAAGTTTTGCTAGCCCTGCTAAGT
TCAGGCTTAGAGGCTTATCGCTAAGTATAAACTTCACCAGATTCCACGAAAAGCTGGATAGCTTTTTTTCTGACTTATGTTGTGGTTGCA
CCCCTCACAAATGGCAGAACAGTATGTAAAGCTGGTAACACCTCGGTTTCAGTGCACCATGTGTTTGCTTTGTGAAGGTGAAGAATATGT
TGGTTTAGAGAAAGAAATTGGATGTAATTTTATGCAATTTACTTTTAAAGACAAACATAACTATTTAGCAGAGAATATTTTAATAAATGC
AAAACAACAGCTGGACTGCTGTACATCAAGGACAGATTAACTGGAAAACATATGTTCCTTATGTGTGATCGAGAGCCATTCAGAAAAGAC
TTCCTTTGTGTTCAGCCTATACTTTTCCATATGGTATACCTTGAAAAAAATTAGCACACCATGGTTATTTTTCTACCTTTTATAAAAGAC
AGAGCCTGTTTACTCATTTAGAAGATAGAGAAAATTGGTCTAAAATTGAACATCCTAGATTCACACTCCCAAGTCACTTAAGGTGATTTG
ATGGTGAGGAAAATGATTGACAAAGCCCAACAATGATCTCAGGAATTACATTTTCCAACAGACCAAAAAATGTTTTCATGTAGCAGCAAT
GCAGATTTGGTGAATATTTAATATATATTTTAGTATGTATTTCACTTTATGACTGACAATTAAAAAATATTGTTTGGCCAAATAGTAAAC

>68132_68132_1_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000323055_SLC39A8_chr4_103184350_ENST00000394833_length(amino acids)=291AA_BP=
MSVWPAGPVGVCSRTDEQRVAVLRQLEMSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALR
IITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHEC
RHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEK

--------------------------------------------------------------
>68132_68132_2_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000394853_SLC39A8_chr4_103184350_ENST00000394833_length(transcript)=2841nt_BP=1313nt
AGCAGCGGCGGCCGCCTCTCCGCCGCCGGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCC
CGGCCTTCCCCATGTGATCGGTCTTAATCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGG
GTGCTCGTGTGTGCGCTTCTCCTCCCCATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAAC
CACCACACACGCGCAGCCCGGAGCGAGTCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCG
CGGAAAAGGCAGCAACTTTAAAGCCAGCTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCG
TTGAGTGTCTGGCCCGCCGGTCCGGTCGGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAG
CCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAA
GTGTTTGATAATGATGGAAAACCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGA
ATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGA
CAATTCTTTGATTTGATGAAGCTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTTGACAGAGGG
TACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTACCCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGT
AGACATCTAACAGAGTATTTCACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGATGCCTTTGAC
TGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGTGGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGA
AAATTAGACCGATTCAAAGAACCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGAAATGAGAAG
ACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTACAGTTTCCAGAGATGAATGATATGCTGAGAGAAAAGGTAA
CTGGAAGAAAAACCGATTTCACCTTCTTCATGATTCAGAATGCTGGAATGTTAACTGGATTCACAGCCATTCTACTCATTACCTTGTATG
CAGGAGAAATCGAATTGGAGTAATAGAAAATGGAAGATGGTGTTGTTAATAAAGGCATTTAATAGATAAAAACATCTCCAAAAAGGATTT
TGAAGCTGATCCTATTTAGTTAAAAAGATAATTTTGCTTTCAACTGTAGGTCCAGAAAACTAATTATTGGCATCAGTCTGTGAAATAGTC
CATTATTTGTTGTTAAAAATGCTTCAAAAGGTTTTCAGTGTCAGTCTGAGATGCCTGGTATATAGGAGCCTTTGGGAAATACCTATTTTT
CAGTATTCCATGCATATTAGATATCACCATGAAGCAAGAGACATGCATTCTATAATCATGTAGACACTCAGACTCAGGGGAAAATACAAG
TTATATCCTGAAAGCCTTTAAAACTCTATGGTAGGATCAAAGATTCAAATGGTTTCAGAGAGGTTTTATTTCAATTAATTTGTTCTAGTG
CTTTCAAGAGCAAGTACATCAAAATGTAGAAGGTAAAATGTATGCAACACTAATATAAATTATTCCAAGTCTTTAAGGAGCCAAAGAAAA
AAAAGATTTCTCACAGCTTTTTGTTCTGTTTTGTATTTCAATTAGGAACTTGCAGTATTATTTTGAAAACCATTCTAAAATAATAGGAGT
TAGGAAATAAATAAAGTTTTGCTAGCCCTGCTAAGTTCAGGCTTAGAGGCTTATCGCTAAGTATAAACTTCACCAGATTCCACGAAAAGC
TGGATAGCTTTTTTTCTGACTTATGTTGTGGTTGCACCCCTCACAAATGGCAGAACAGTATGTAAAGCTGGTAACACCTCGGTTTCAGTG
CACCATGTGTTTGCTTTGTGAAGGTGAAGAATATGTTGGTTTAGAGAAAGAAATTGGATGTAATTTTATGCAATTTACTTTTAAAGACAA
ACATAACTATTTAGCAGAGAATATTTTAATAAATGCAAAACAACAGCTGGACTGCTGTACATCAAGGACAGATTAACTGGAAAACATATG
TTCCTTATGTGTGATCGAGAGCCATTCAGAAAAGACTTCCTTTGTGTTCAGCCTATACTTTTCCATATGGTATACCTTGAAAAAAATTAG
CACACCATGGTTATTTTTCTACCTTTTATAAAAGACAGAGCCTGTTTACTCATTTAGAAGATAGAGAAAATTGGTCTAAAATTGAACATC
CTAGATTCACACTCCCAAGTCACTTAAGGTGATTTGATGGTGAGGAAAATGATTGACAAAGCCCAACAATGATCTCAGGAATTACATTTT
CCAACAGACCAAAAAATGTTTTCATGTAGCAGCAATGCAGATTTGGTGAATATTTAATATATATTTTAGTATGTATTTCACTTTATGACT

>68132_68132_2_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000394853_SLC39A8_chr4_103184350_ENST00000394833_length(amino acids)=291AA_BP=
MSVWPAGPVGVCSRTDEQRVAVLRQLEMSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALR
IITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHEC
RHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEK

--------------------------------------------------------------
>68132_68132_3_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000394854_SLC39A8_chr4_103184350_ENST00000394833_length(transcript)=2994nt_BP=1466nt
GGTGAGTGGAGGAGCGGCGCGGGGAGGCAGAGGCGAGCGCGGGCGATCGCGGCGGCGGGACGTCTCCGGCGGCCGCGGCACCAGCGGCGG
CGCTCTGTGTGGAGAAGCAGGGGCAGCGGCAGCAGCAACAGCGGCAGCGGCAGCAGCAGCGGCAGCAGCGGCGGCCGCCTCTCCGCCGCC
GGGGACGCCAAGGTGCGGCTGGTGGCACTGACATCGGCGGCCCTGCCTCTCCTCCCTCGCCCCCGGCCTTCCCCATGTGATCGGTCTTAA
TCCTGGCCGTGTGTGCGCGCGTGGGGCTCCATTCCGCGGTGCTGGGTCTCCGTGCCGGGGTGGGTGCTCGTGTGTGCGCTTCTCCTCCCC
ATCCCCCTTCCCCCAAGAATAAAAGAAGAACCGGGAGGCGTGCTCAGAAAATAAATAAATAACCACCACACACGCGCAGCCCGGAGCGAG
TCGGCGGGGCTGGCGGCAGCGGCGGAGGAGGAGTGAAGGCGGCGGCGGCGGAGGAGGGACGCGCGGAAAAGGCAGCAACTTTAAAGCCAG
CTCAGAGCCTAGACCTCCAGCCGAGCGGTTTGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGTTGAGTGTCTGGCCCGCCGGTCCGGTC
GGGGTGTGCAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCG
ACGACCGACAGGGTGGTGAAAGCTGTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAACCTCGT
GTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTTGCATTGAGAATAATAACAGAGGGTGCATCAATTCTT
CGACAGGAAAAAAATTTGCTGGATATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAGCTCTTT
GAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTTGACAGAGGGTACTTCAGTATTGAATGTGTGCTGTAT
TTGTGGGCCTTGAAAATTCTCTACCCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTCACATTT
AAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGATGCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAAC
CAACAGTTCCTGTGTGTGCATGGTGGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAACCACCT
GCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGAAATGAGAAGACTCAGGAACATTTCACTCACAACACA
GTCAGGGGGTGTTCATACTTCTACAGTTTCCAGAGATGAATGATATGCTGAGAGAAAAGGTAACTGGAAGAAAAACCGATTTCACCTTCT
TCATGATTCAGAATGCTGGAATGTTAACTGGATTCACAGCCATTCTACTCATTACCTTGTATGCAGGAGAAATCGAATTGGAGTAATAGA
AAATGGAAGATGGTGTTGTTAATAAAGGCATTTAATAGATAAAAACATCTCCAAAAAGGATTTTGAAGCTGATCCTATTTAGTTAAAAAG
ATAATTTTGCTTTCAACTGTAGGTCCAGAAAACTAATTATTGGCATCAGTCTGTGAAATAGTCCATTATTTGTTGTTAAAAATGCTTCAA
AAGGTTTTCAGTGTCAGTCTGAGATGCCTGGTATATAGGAGCCTTTGGGAAATACCTATTTTTCAGTATTCCATGCATATTAGATATCAC
CATGAAGCAAGAGACATGCATTCTATAATCATGTAGACACTCAGACTCAGGGGAAAATACAAGTTATATCCTGAAAGCCTTTAAAACTCT
ATGGTAGGATCAAAGATTCAAATGGTTTCAGAGAGGTTTTATTTCAATTAATTTGTTCTAGTGCTTTCAAGAGCAAGTACATCAAAATGT
AGAAGGTAAAATGTATGCAACACTAATATAAATTATTCCAAGTCTTTAAGGAGCCAAAGAAAAAAAAGATTTCTCACAGCTTTTTGTTCT
GTTTTGTATTTCAATTAGGAACTTGCAGTATTATTTTGAAAACCATTCTAAAATAATAGGAGTTAGGAAATAAATAAAGTTTTGCTAGCC
CTGCTAAGTTCAGGCTTAGAGGCTTATCGCTAAGTATAAACTTCACCAGATTCCACGAAAAGCTGGATAGCTTTTTTTCTGACTTATGTT
GTGGTTGCACCCCTCACAAATGGCAGAACAGTATGTAAAGCTGGTAACACCTCGGTTTCAGTGCACCATGTGTTTGCTTTGTGAAGGTGA
AGAATATGTTGGTTTAGAGAAAGAAATTGGATGTAATTTTATGCAATTTACTTTTAAAGACAAACATAACTATTTAGCAGAGAATATTTT
AATAAATGCAAAACAACAGCTGGACTGCTGTACATCAAGGACAGATTAACTGGAAAACATATGTTCCTTATGTGTGATCGAGAGCCATTC
AGAAAAGACTTCCTTTGTGTTCAGCCTATACTTTTCCATATGGTATACCTTGAAAAAAATTAGCACACCATGGTTATTTTTCTACCTTTT
ATAAAAGACAGAGCCTGTTTACTCATTTAGAAGATAGAGAAAATTGGTCTAAAATTGAACATCCTAGATTCACACTCCCAAGTCACTTAA
GGTGATTTGATGGTGAGGAAAATGATTGACAAAGCCCAACAATGATCTCAGGAATTACATTTTCCAACAGACCAAAAAATGTTTTCATGT
AGCAGCAATGCAGATTTGGTGAATATTTAATATATATTTTAGTATGTATTTCACTTTATGACTGACAATTAAAAAATATTGTTTGGCCAA

>68132_68132_3_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000394854_SLC39A8_chr4_103184350_ENST00000394833_length(amino acids)=291AA_BP=
MSVWPAGPVGVCSRTDEQRVAVLRQLEMSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALR
IITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHEC
RHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEK

--------------------------------------------------------------
>68132_68132_4_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000507176_SLC39A8_chr4_103184350_ENST00000394833_length(transcript)=2155nt_BP=627nt
CAGTCGGACGGACGAGCAGCGCGTCGCTGTCCTCCGGCAGCTGGAGATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGA
CAGGGTGGTGAAAGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAGCTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCG
CTACCTCTTCTTAGGGGACTATGTTGACAGAGGGTACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTACCCCAA
AACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTCACATTTAAACAAGAATGTAAAATAAAGTATTCAGA
ACGCGTATATGATGCCTGTATGGATGCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGTGGTTT
GTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAACCACCTGCATATGGACCTATGTGTGATATCCTGTG
GTCAGACCCCCTGGAAGATTTTGGAAATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTACAGTTT
CCAGAGATGAATGATATGCTGAGAGAAAAGGTAACTGGAAGAAAAACCGATTTCACCTTCTTCATGATTCAGAATGCTGGAATGTTAACT
GGATTCACAGCCATTCTACTCATTACCTTGTATGCAGGAGAAATCGAATTGGAGTAATAGAAAATGGAAGATGGTGTTGTTAATAAAGGC
ATTTAATAGATAAAAACATCTCCAAAAAGGATTTTGAAGCTGATCCTATTTAGTTAAAAAGATAATTTTGCTTTCAACTGTAGGTCCAGA
AAACTAATTATTGGCATCAGTCTGTGAAATAGTCCATTATTTGTTGTTAAAAATGCTTCAAAAGGTTTTCAGTGTCAGTCTGAGATGCCT
GGTATATAGGAGCCTTTGGGAAATACCTATTTTTCAGTATTCCATGCATATTAGATATCACCATGAAGCAAGAGACATGCATTCTATAAT
CATGTAGACACTCAGACTCAGGGGAAAATACAAGTTATATCCTGAAAGCCTTTAAAACTCTATGGTAGGATCAAAGATTCAAATGGTTTC
AGAGAGGTTTTATTTCAATTAATTTGTTCTAGTGCTTTCAAGAGCAAGTACATCAAAATGTAGAAGGTAAAATGTATGCAACACTAATAT
AAATTATTCCAAGTCTTTAAGGAGCCAAAGAAAAAAAAGATTTCTCACAGCTTTTTGTTCTGTTTTGTATTTCAATTAGGAACTTGCAGT
ATTATTTTGAAAACCATTCTAAAATAATAGGAGTTAGGAAATAAATAAAGTTTTGCTAGCCCTGCTAAGTTCAGGCTTAGAGGCTTATCG
CTAAGTATAAACTTCACCAGATTCCACGAAAAGCTGGATAGCTTTTTTTCTGACTTATGTTGTGGTTGCACCCCTCACAAATGGCAGAAC
AGTATGTAAAGCTGGTAACACCTCGGTTTCAGTGCACCATGTGTTTGCTTTGTGAAGGTGAAGAATATGTTGGTTTAGAGAAAGAAATTG
GATGTAATTTTATGCAATTTACTTTTAAAGACAAACATAACTATTTAGCAGAGAATATTTTAATAAATGCAAAACAACAGCTGGACTGCT
GTACATCAAGGACAGATTAACTGGAAAACATATGTTCCTTATGTGTGATCGAGAGCCATTCAGAAAAGACTTCCTTTGTGTTCAGCCTAT
ACTTTTCCATATGGTATACCTTGAAAAAAATTAGCACACCATGGTTATTTTTCTACCTTTTATAAAAGACAGAGCCTGTTTACTCATTTA
GAAGATAGAGAAAATTGGTCTAAAATTGAACATCCTAGATTCACACTCCCAAGTCACTTAAGGTGATTTGATGGTGAGGAAAATGATTGA
CAAAGCCCAACAATGATCTCAGGAATTACATTTTCCAACAGACCAAAAAATGTTTTCATGTAGCAGCAATGCAGATTTGGTGAATATTTA

>68132_68132_4_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000507176_SLC39A8_chr4_103184350_ENST00000394833_length(amino acids)=199AA_BP=
MEMSEPKAIDPKLSTTDRVVKVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRH
LTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQ

--------------------------------------------------------------
>68132_68132_5_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000523694_SLC39A8_chr4_103184350_ENST00000394833_length(transcript)=2109nt_BP=581nt
ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGTTTGTGGGGACATTCATGGACAATTCTTTGAT
TTGATGAAGCTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTTGACAGAGGGTACTTCAGTATT
GAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTACCCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACA
GAGTATTTCACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGATGCCTTTGACTGCCTTCCCCTG
GCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGTGGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGA
TTCAAAGAACCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGAAATGAGAAGACTCAGGAACAT
TTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTACAGTTTCCAGAGATGAATGATATGCTGAGAGAAAAGGTAACTGGAAGAAAAA
CCGATTTCACCTTCTTCATGATTCAGAATGCTGGAATGTTAACTGGATTCACAGCCATTCTACTCATTACCTTGTATGCAGGAGAAATCG
AATTGGAGTAATAGAAAATGGAAGATGGTGTTGTTAATAAAGGCATTTAATAGATAAAAACATCTCCAAAAAGGATTTTGAAGCTGATCC
TATTTAGTTAAAAAGATAATTTTGCTTTCAACTGTAGGTCCAGAAAACTAATTATTGGCATCAGTCTGTGAAATAGTCCATTATTTGTTG
TTAAAAATGCTTCAAAAGGTTTTCAGTGTCAGTCTGAGATGCCTGGTATATAGGAGCCTTTGGGAAATACCTATTTTTCAGTATTCCATG
CATATTAGATATCACCATGAAGCAAGAGACATGCATTCTATAATCATGTAGACACTCAGACTCAGGGGAAAATACAAGTTATATCCTGAA
AGCCTTTAAAACTCTATGGTAGGATCAAAGATTCAAATGGTTTCAGAGAGGTTTTATTTCAATTAATTTGTTCTAGTGCTTTCAAGAGCA
AGTACATCAAAATGTAGAAGGTAAAATGTATGCAACACTAATATAAATTATTCCAAGTCTTTAAGGAGCCAAAGAAAAAAAAGATTTCTC
ACAGCTTTTTGTTCTGTTTTGTATTTCAATTAGGAACTTGCAGTATTATTTTGAAAACCATTCTAAAATAATAGGAGTTAGGAAATAAAT
AAAGTTTTGCTAGCCCTGCTAAGTTCAGGCTTAGAGGCTTATCGCTAAGTATAAACTTCACCAGATTCCACGAAAAGCTGGATAGCTTTT
TTTCTGACTTATGTTGTGGTTGCACCCCTCACAAATGGCAGAACAGTATGTAAAGCTGGTAACACCTCGGTTTCAGTGCACCATGTGTTT
GCTTTGTGAAGGTGAAGAATATGTTGGTTTAGAGAAAGAAATTGGATGTAATTTTATGCAATTTACTTTTAAAGACAAACATAACTATTT
AGCAGAGAATATTTTAATAAATGCAAAACAACAGCTGGACTGCTGTACATCAAGGACAGATTAACTGGAAAACATATGTTCCTTATGTGT
GATCGAGAGCCATTCAGAAAAGACTTCCTTTGTGTTCAGCCTATACTTTTCCATATGGTATACCTTGAAAAAAATTAGCACACCATGGTT
ATTTTTCTACCTTTTATAAAAGACAGAGCCTGTTTACTCATTTAGAAGATAGAGAAAATTGGTCTAAAATTGAACATCCTAGATTCACAC
TCCCAAGTCACTTAAGGTGATTTGATGGTGAGGAAAATGATTGACAAAGCCCAACAATGATCTCAGGAATTACATTTTCCAACAGACCAA
AAAATGTTTTCATGTAGCAGCAATGCAGATTTGGTGAATATTTAATATATATTTTAGTATGTATTTCACTTTATGACTGACAATTAAAAA

>68132_68132_5_PPP3CA-SLC39A8_PPP3CA_chr4_102014932_ENST00000523694_SLC39A8_chr4_103184350_ENST00000394833_length(amino acids)=197AA_BP=
MSEPKAIDPKLSTTDRVVKVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLT
EYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP3CA-SLC39A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPP3CAchr4:102014932chr4:103184350ENST00000323055-612327_336260.6666666666667470.0PxIxIF motif in substrate
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394853-613327_336260.6666666666667512.0PxIxIF motif in substrate
HgenePPP3CAchr4:102014932chr4:103184350ENST00000394854-614327_336260.6666666666667522.0PxIxIF motif in substrate
HgenePPP3CAchr4:102014932chr4:103184350ENST00000512215-18327_3360290.0PxIxIF motif in substrate


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP3CA-SLC39A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP3CA-SLC39A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource