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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP3CB-TTC18 (FusionGDB2 ID:68145)

Fusion Gene Summary for PPP3CB-TTC18

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3CB-TTC18
Fusion gene ID: 68145
HgeneTgene
Gene symbol

PPP3CB

TTC18

Gene ID

5532

118491

Gene nameprotein phosphatase 3 catalytic subunit betacilia and flagella associated protein 70
SynonymsCALNA2|CALNB|CNA2|PP2BbetaSPGF41|TTC18
Cytomap

10q22.2

10q22.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2B catalytic subunit beta isoformCAM-PRP catalytic subunitCNA betacalcineurin A betacalcineurin A2calmodulin-dependent calcineurin A subunit beta isoformprotein phosphatase 2B, catalytic subunit, beta isoformprocilia- and flagella-associated protein 70TPR repeat protein 18tetratricopeptide repeat domain 18tetratricopeptide repeat protein 18tetratricopeptide repeat-containing protein (LOC118491)
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000342558, ENST00000360663, 
ENST00000394822, ENST00000394828, 
ENST00000394829, ENST00000544628, 
ENST00000545874, ENST00000495897, 
ENST00000493787, ENST00000340329, 
ENST00000355577, ENST00000394865, 
ENST00000310715, ENST00000401621, 
Fusion gene scores* DoF score9 X 9 X 5=4056 X 6 X 5=180
# samples 109
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP3CB [Title/Abstract] AND TTC18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP3CB(75214170)-TTC18(75035356), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP3CB-TTC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3CB

GO:0006470

protein dephosphorylation

19154138|26794871

HgenePPP3CB

GO:0033173

calcineurin-NFAT signaling cascade

19154138|22688515

HgenePPP3CB

GO:0035690

cellular response to drug

11005320

HgenePPP3CB

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check buttonFusion gene breakpoints across PPP3CB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTC18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A6TE-01APPP3CBchr10

75214170

-TTC18chr10

75035356

-


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Fusion Gene ORF analysis for PPP3CB-TTC18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000342558ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000360663ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000394822ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000394828ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000394829ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000544628ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-5UTRENST00000545874ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000342558ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000342558ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000342558ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000360663ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000360663ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000360663ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394822ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394822ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394822ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394828ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394828ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394828ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394829ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394829ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000394829ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000544628ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000544628ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000544628ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000545874ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000545874ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
5CDS-intronENST00000545874ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000342558ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000342558ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000360663ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000360663ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394822ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394822ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394828ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394828ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394829ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
Frame-shiftENST00000394829ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
In-frameENST00000544628ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
In-frameENST00000544628ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
In-frameENST00000545874ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
In-frameENST00000545874ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-3CDSENST00000495897ENST00000310715PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-3CDSENST00000495897ENST00000401621PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-5UTRENST00000495897ENST00000493787PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-intronENST00000495897ENST00000340329PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-intronENST00000495897ENST00000355577PPP3CBchr10

75214170

-TTC18chr10

75035356

-
intron-intronENST00000495897ENST00000394865PPP3CBchr10

75214170

-TTC18chr10

75035356

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545874PPP3CBchr1075214170-ENST00000310715TTC18chr1075035356-219913472721372366
ENST00000545874PPP3CBchr1075214170-ENST00000401621TTC18chr1075035356-219913472721372366
ENST00000544628PPP3CBchr1075214170-ENST00000310715TTC18chr1075035356-96911793752219
ENST00000544628PPP3CBchr1075214170-ENST00000401621TTC18chr1075035356-96911793752219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545874ENST00000310715PPP3CBchr1075214170-TTC18chr1075035356-0.0006445560.9993555
ENST00000545874ENST00000401621PPP3CBchr1075214170-TTC18chr1075035356-0.0006445560.9993555
ENST00000544628ENST00000310715PPP3CBchr1075214170-TTC18chr1075035356-0.0018821540.9981179
ENST00000544628ENST00000401621PPP3CBchr1075214170-TTC18chr1075035356-0.0018821540.9981179

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Fusion Genomic Features for PPP3CB-TTC18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3CB-TTC18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:75214170/chr10:75035356)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-101411_21395525.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-111311_21413515.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-101311_21395516.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-101411_21395526.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-1014316_320395525.0MotifSAPNY motif
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-1113316_320413515.0MotifSAPNY motif
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-1013316_320395516.0MotifSAPNY motif
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-1014316_320395526.0MotifSAPNY motif
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-1014357_379395525.0RegionCalcineurin B binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-101465_356395525.0RegionCatalytic
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-1113357_379413515.0RegionCalcineurin B binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-1113401_415413515.0RegionCalmodulin-binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-111365_356413515.0RegionCatalytic
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-1013357_379395516.0RegionCalcineurin B binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-101365_356395516.0RegionCatalytic
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-1014357_379395526.0RegionCalcineurin B binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-101465_356395526.0RegionCatalytic
TgeneTTC18chr10:75214170chr10:75035356ENST0000039486521271000_10339101092.0RepeatNote=TPR 6
TgeneTTC18chr10:75214170chr10:75035356ENST0000039486521271035_10669101092.0RepeatNote=TPR 7
TgeneTTC18chr10:75214170chr10:75035356ENST0000039486521271068_11009101092.0RepeatNote=TPR 8
TgeneTTC18chr10:75214170chr10:75035356ENST000003948652127929_9629101092.0RepeatNote=TPR 4
TgeneTTC18chr10:75214170chr10:75035356ENST000003948652127963_9969101092.0RepeatNote=TPR 5
TgeneTTC18chr10:75214170chr10:75035356ENST0000040162121281000_10339101122.0RepeatNote=TPR 6
TgeneTTC18chr10:75214170chr10:75035356ENST0000040162121281035_10669101122.0RepeatNote=TPR 7
TgeneTTC18chr10:75214170chr10:75035356ENST0000040162121281068_11009101122.0RepeatNote=TPR 8
TgeneTTC18chr10:75214170chr10:75035356ENST000004016212128929_9629101122.0RepeatNote=TPR 4
TgeneTTC18chr10:75214170chr10:75035356ENST000004016212128963_9969101122.0RepeatNote=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-1014401_415395525.0RegionCalmodulin-binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-1014416_423395525.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75214170chr10:75035356ENST00000360663-1014474_496395525.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-1113416_423413515.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394822-1113474_496413515.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-1013401_415395516.0RegionCalmodulin-binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-1013416_423395516.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394828-1013474_496395516.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-1014401_415395526.0RegionCalmodulin-binding
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-1014416_423395526.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75214170chr10:75035356ENST00000394829-1014474_496395526.0RegionAutoinhibitory domain
TgeneTTC18chr10:75214170chr10:75035356ENST000003948652127635_6689101092.0RepeatNote=TPR 1
TgeneTTC18chr10:75214170chr10:75035356ENST000003948652127669_7029101092.0RepeatNote=TPR 2
TgeneTTC18chr10:75214170chr10:75035356ENST000003948652127704_7369101092.0RepeatNote=TPR 3
TgeneTTC18chr10:75214170chr10:75035356ENST000004016212128635_6689101122.0RepeatNote=TPR 1
TgeneTTC18chr10:75214170chr10:75035356ENST000004016212128669_7029101122.0RepeatNote=TPR 2
TgeneTTC18chr10:75214170chr10:75035356ENST000004016212128704_7369101122.0RepeatNote=TPR 3


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Fusion Gene Sequence for PPP3CB-TTC18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68145_68145_1_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000544628_TTC18_chr10_75035356_ENST00000310715_length(transcript)=969nt_BP=117nt
AATGTAATATGGGAAGGATGGAGGGGCCAGGAAGATAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATTTGCTCTGATGATGAACTAA
TGACTGAAGGTGAAGACCAGTTTGATGTATGTGCACAGAGTGCTTGCACATGAGCTGTTATGCCCTCAAGGAGGCCCCAGCTGTGAATAT
TACTTGGTGCTGGCCCAAACACACATTCTTAAGAAGAACTTTGCCAAGGCAGAGGAATACCTTCAACAAGCAGCCCAGATGGACTACCTG
AACCCCAATGTCTGGGGCCTGAAGGGCCATCTCTATTTTCTGAGTGGAAATCATTCTGAGGCCAAGGCATGCTATGAACGAACCATTAGC
TTTGTAGTGGATGCTTCTGAGATGCACTTCATCTTCCTGAGACTGGGGCTCATCTATCTGGAAGAGAAAGAGTATGAAAAGGCAAAGAAA
ACCTATATGCAAGCCTGTAAGAGATCACCTTCATGCCTTACCTGGCTAGGACTGGGAATCGCCTGCTATCGGCTGGAGGAGCTCACAGAG
GCTGAGGATGCTCTTTCTGAAGCCAATGCATTGAACAACTACAATGCTGAAGTATGGGCATATCTGGCTCTGGTCTGCCTGAAAGTTGGA
CGGCAATTAGAAGCTGAGCAGGCCTACAAGTACATGATCAAGCTGAAATTGAAAGATGAGGCTCTGCTTGCAGAGATCCACACACTACAG
GAAACAGTTGGCTTTGGAAATCCATCTTTCTGATACCCCTCCAGCTGAACAATTTTCTGCATGGGACTCTGAGTTCCTTTCCTTCCCAGA
GAGTTTTACCGTATGAAGCCTGGAGCTGGAGAACGAAAGAATCTTCACTATAAACAGAGACCCATTCATTTATTTCCATTGGCTGTGTTA

>68145_68145_1_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000544628_TTC18_chr10_75035356_ENST00000310715_length(amino acids)=219AA_BP=5
MKVKTSLMYVHRVLAHELLCPQGGPSCEYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTISF
VVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWLGLGIACYRLEELTEAEDALSEANALNNYNAEVWAYLALVCLKVGR

--------------------------------------------------------------
>68145_68145_2_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000544628_TTC18_chr10_75035356_ENST00000401621_length(transcript)=969nt_BP=117nt
AATGTAATATGGGAAGGATGGAGGGGCCAGGAAGATAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATTTGCTCTGATGATGAACTAA
TGACTGAAGGTGAAGACCAGTTTGATGTATGTGCACAGAGTGCTTGCACATGAGCTGTTATGCCCTCAAGGAGGCCCCAGCTGTGAATAT
TACTTGGTGCTGGCCCAAACACACATTCTTAAGAAGAACTTTGCCAAGGCAGAGGAATACCTTCAACAAGCAGCCCAGATGGACTACCTG
AACCCCAATGTCTGGGGCCTGAAGGGCCATCTCTATTTTCTGAGTGGAAATCATTCTGAGGCCAAGGCATGCTATGAACGAACCATTAGC
TTTGTAGTGGATGCTTCTGAGATGCACTTCATCTTCCTGAGACTGGGGCTCATCTATCTGGAAGAGAAAGAGTATGAAAAGGCAAAGAAA
ACCTATATGCAAGCCTGTAAGAGATCACCTTCATGCCTTACCTGGCTAGGACTGGGAATCGCCTGCTATCGGCTGGAGGAGCTCACAGAG
GCTGAGGATGCTCTTTCTGAAGCCAATGCATTGAACAACTACAATGCTGAAGTATGGGCATATCTGGCTCTGGTCTGCCTGAAAGTTGGA
CGGCAATTAGAAGCTGAGCAGGCCTACAAGTACATGATCAAGCTGAAATTGAAAGATGAGGCTCTGCTTGCAGAGATCCACACACTACAG
GAAACAGTTGGCTTTGGAAATCCATCTTTCTGATACCCCTCCAGCTGAACAATTTTCTGCATGGGACTCTGAGTTCCTTTCCTTCCCAGA
GAGTTTTACCGTATGAAGCCTGGAGCTGGAGAACGAAAGAATCTTCACTATAAACAGAGACCCATTCATTTATTTCCATTGGCTGTGTTA

>68145_68145_2_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000544628_TTC18_chr10_75035356_ENST00000401621_length(amino acids)=219AA_BP=5
MKVKTSLMYVHRVLAHELLCPQGGPSCEYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTISF
VVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWLGLGIACYRLEELTEAEDALSEANALNNYNAEVWAYLALVCLKVGR

--------------------------------------------------------------
>68145_68145_3_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000545874_TTC18_chr10_75035356_ENST00000310715_length(transcript)=2199nt_BP=1347nt
AACCCCGCCCGGCCCAGAGCCTAGCCGAGCCCCGGGCCCAGCATGGCCGCCCCGGAGCCGGCCCGGGCTGCACCGCCCCCACCCCCGCCC
CCGCCGCCCCCTCCCGGGGCTGACCGCGTCGTCAAAGGCTGGTCTCCAATTTCTGGCCTCAAGTGATCCTCCTGCCCCAGCCTACGAAGT
AGTCGTGATTACAGACATGCTTCACTACTCCCAGCATTAAATTATATTTATTGTACTTCATTTAAGCTGTCCCTTTCCCCCCAACACATC
GCTTGACATCTGAAGAAGTATTTGATTTGGATGGGATACCCAGGGTTGATGTTCTGAAGAACCACTTGGTGAAAGAAGGTCGAGTAGATG
AAGAAATTGCGCTTAGAATTATCAATGAGGGTGCTGCCATCCTTCGGAGAGAGAAAACCATGATAGAAGTAGAAGCTCCAATCACAGTGT
GTGGTGACATCCATGGCCAATTTTTTGATCTGATGAAACTTTTTGAAGTAGGAGGATCACCTGCTAATACACGATACCTTTTTCTTGGCG
ATTATGTGGACAGAGGTTATTTTAGTATAGAGTGTGTCTTATATTTATGGGTTCTGAAGATTCTATACCCAAGCACATTATTTCTTCTGA
GAGGCAACCATGAATGCAGACACCTTACTGAATATTTTACCTTTAAGCAGGAATGTAAAATTAAGTATTCGGAAAGAGTCTATGAAGCTT
GTATGGAAGCTTTTGATAGTTTGCCTCTTGCTGCACTTTTAAACCAACAGTTTCTTTGTGTTCATGGTGGACTTTCACCAGAAATACACA
CACTGGATGATATTAGGAGATTAGATAGATTCAAAGAGCCACCTGCATTTGGACCAATGTGTGACTTGTTATGGTCCGATCCTTCTGAAG
ATTTTGGAAATGAAAAATCACAGGAACATTTTAGTCACAATACAGTTCGAGGATGTTCTTATTTTTATAACTATCCAGCAGTGTGTGAAT
TTTTGCAAAACAATAATTTGTTATCGATTATTAGAGCTCATGAAGCTCAAGATGCAGGCTATAGAATGTACAGAAAAAGTCAAACTACAG
GGTTCCCTTCATTAATAACAATTTTTTCGGCACCTAATTACTTAGATGTCTACAATAATAAAGCTGCTGTATTAAAGTATGAAAATAATG
TGATGAATATTCGACAGTTTAACTGTTCTCCACATCCTTACTGGTTGCCTAATTTTATGGATGTCTTCACGTGGTCTTTACCGTTTGTTG
GAGAAAAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATTTGCTCTGATGATGAACTAATGACTGAAGGTGAAGACCAGTTTGATGTAT
GTGCACAGAGTGCTTGCACATGAGCTGTTATGCCCTCAAGGAGGCCCCAGCTGTGAATATTACTTGGTGCTGGCCCAAACACACATTCTT
AAGAAGAACTTTGCCAAGGCAGAGGAATACCTTCAACAAGCAGCCCAGATGGACTACCTGAACCCCAATGTCTGGGGCCTGAAGGGCCAT
CTCTATTTTCTGAGTGGAAATCATTCTGAGGCCAAGGCATGCTATGAACGAACCATTAGCTTTGTAGTGGATGCTTCTGAGATGCACTTC
ATCTTCCTGAGACTGGGGCTCATCTATCTGGAAGAGAAAGAGTATGAAAAGGCAAAGAAAACCTATATGCAAGCCTGTAAGAGATCACCT
TCATGCCTTACCTGGCTAGGACTGGGAATCGCCTGCTATCGGCTGGAGGAGCTCACAGAGGCTGAGGATGCTCTTTCTGAAGCCAATGCA
TTGAACAACTACAATGCTGAAGTATGGGCATATCTGGCTCTGGTCTGCCTGAAAGTTGGACGGCAATTAGAAGCTGAGCAGGCCTACAAG
TACATGATCAAGCTGAAATTGAAAGATGAGGCTCTGCTTGCAGAGATCCACACACTACAGGAAACAGTTGGCTTTGGAAATCCATCTTTC
TGATACCCCTCCAGCTGAACAATTTTCTGCATGGGACTCTGAGTTCCTTTCCTTCCCAGAGAGTTTTACCGTATGAAGCCTGGAGCTGGA
GAACGAAAGAATCTTCACTATAAACAGAGACCCATTCATTTATTTCCATTGGCTGTGTTACTGGATGTTTTACTGGTTGACGAGAAACTG

>68145_68145_3_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000545874_TTC18_chr10_75035356_ENST00000310715_length(amino acids)=366AA_BP=1
MTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGD
YVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHT
LDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTG
FPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVC

--------------------------------------------------------------
>68145_68145_4_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000545874_TTC18_chr10_75035356_ENST00000401621_length(transcript)=2199nt_BP=1347nt
AACCCCGCCCGGCCCAGAGCCTAGCCGAGCCCCGGGCCCAGCATGGCCGCCCCGGAGCCGGCCCGGGCTGCACCGCCCCCACCCCCGCCC
CCGCCGCCCCCTCCCGGGGCTGACCGCGTCGTCAAAGGCTGGTCTCCAATTTCTGGCCTCAAGTGATCCTCCTGCCCCAGCCTACGAAGT
AGTCGTGATTACAGACATGCTTCACTACTCCCAGCATTAAATTATATTTATTGTACTTCATTTAAGCTGTCCCTTTCCCCCCAACACATC
GCTTGACATCTGAAGAAGTATTTGATTTGGATGGGATACCCAGGGTTGATGTTCTGAAGAACCACTTGGTGAAAGAAGGTCGAGTAGATG
AAGAAATTGCGCTTAGAATTATCAATGAGGGTGCTGCCATCCTTCGGAGAGAGAAAACCATGATAGAAGTAGAAGCTCCAATCACAGTGT
GTGGTGACATCCATGGCCAATTTTTTGATCTGATGAAACTTTTTGAAGTAGGAGGATCACCTGCTAATACACGATACCTTTTTCTTGGCG
ATTATGTGGACAGAGGTTATTTTAGTATAGAGTGTGTCTTATATTTATGGGTTCTGAAGATTCTATACCCAAGCACATTATTTCTTCTGA
GAGGCAACCATGAATGCAGACACCTTACTGAATATTTTACCTTTAAGCAGGAATGTAAAATTAAGTATTCGGAAAGAGTCTATGAAGCTT
GTATGGAAGCTTTTGATAGTTTGCCTCTTGCTGCACTTTTAAACCAACAGTTTCTTTGTGTTCATGGTGGACTTTCACCAGAAATACACA
CACTGGATGATATTAGGAGATTAGATAGATTCAAAGAGCCACCTGCATTTGGACCAATGTGTGACTTGTTATGGTCCGATCCTTCTGAAG
ATTTTGGAAATGAAAAATCACAGGAACATTTTAGTCACAATACAGTTCGAGGATGTTCTTATTTTTATAACTATCCAGCAGTGTGTGAAT
TTTTGCAAAACAATAATTTGTTATCGATTATTAGAGCTCATGAAGCTCAAGATGCAGGCTATAGAATGTACAGAAAAAGTCAAACTACAG
GGTTCCCTTCATTAATAACAATTTTTTCGGCACCTAATTACTTAGATGTCTACAATAATAAAGCTGCTGTATTAAAGTATGAAAATAATG
TGATGAATATTCGACAGTTTAACTGTTCTCCACATCCTTACTGGTTGCCTAATTTTATGGATGTCTTCACGTGGTCTTTACCGTTTGTTG
GAGAAAAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATTTGCTCTGATGATGAACTAATGACTGAAGGTGAAGACCAGTTTGATGTAT
GTGCACAGAGTGCTTGCACATGAGCTGTTATGCCCTCAAGGAGGCCCCAGCTGTGAATATTACTTGGTGCTGGCCCAAACACACATTCTT
AAGAAGAACTTTGCCAAGGCAGAGGAATACCTTCAACAAGCAGCCCAGATGGACTACCTGAACCCCAATGTCTGGGGCCTGAAGGGCCAT
CTCTATTTTCTGAGTGGAAATCATTCTGAGGCCAAGGCATGCTATGAACGAACCATTAGCTTTGTAGTGGATGCTTCTGAGATGCACTTC
ATCTTCCTGAGACTGGGGCTCATCTATCTGGAAGAGAAAGAGTATGAAAAGGCAAAGAAAACCTATATGCAAGCCTGTAAGAGATCACCT
TCATGCCTTACCTGGCTAGGACTGGGAATCGCCTGCTATCGGCTGGAGGAGCTCACAGAGGCTGAGGATGCTCTTTCTGAAGCCAATGCA
TTGAACAACTACAATGCTGAAGTATGGGCATATCTGGCTCTGGTCTGCCTGAAAGTTGGACGGCAATTAGAAGCTGAGCAGGCCTACAAG
TACATGATCAAGCTGAAATTGAAAGATGAGGCTCTGCTTGCAGAGATCCACACACTACAGGAAACAGTTGGCTTTGGAAATCCATCTTTC
TGATACCCCTCCAGCTGAACAATTTTCTGCATGGGACTCTGAGTTCCTTTCCTTCCCAGAGAGTTTTACCGTATGAAGCCTGGAGCTGGA
GAACGAAAGAATCTTCACTATAAACAGAGACCCATTCATTTATTTCCATTGGCTGTGTTACTGGATGTTTTACTGGTTGACGAGAAACTG

>68145_68145_4_PPP3CB-TTC18_PPP3CB_chr10_75214170_ENST00000545874_TTC18_chr10_75035356_ENST00000401621_length(amino acids)=366AA_BP=1
MTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGD
YVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHT
LDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTG
FPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP3CB-TTC18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP3CB-TTC18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP3CB-TTC18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource