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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP3R1-CBWD2 (FusionGDB2 ID:68162)

Fusion Gene Summary for PPP3R1-CBWD2

Fusion gene summary

Fusion gene information	Fusion gene name: PPP3R1-CBWD2
	Fusion gene ID: 68162
		Hgene	Tgene
	Gene symbol	PPP3R1	CBWD2
	Gene ID	5534	150472
	Gene name	protein phosphatase 3 regulatory subunit B, alpha	COBW domain containing 2
	Synonyms	CALNB1\|CNB\|CNB1	-
	Cytomap	2p14	2q14.1
	Type of gene	protein-coding	protein-coding
	Description	calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I	COBW domain-containing protein 2cobalamin synthase W domain-containing protein 2cobalamin synthetase W domain-containing protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IUF1
	Ensembl transtripts involved in fusion gene	ENST00000409377, ENST00000234310, ENST00000409752,	ENST00000259199, ENST00000416503, ENST00000433343,
Fusion gene scores	* DoF score	10 X 7 X 8=560	2 X 2 X 2=8
	# samples	13	2
	** MAII score	log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: PPP3R1 [Title/Abstract] AND CBWD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP3R1(68413599)-CBWD2(114251333), # samples:1
Anticipated loss of major functional domain due to fusion event.	PPP3R1-CBWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PPP3R1-CBWD2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP3R1	GO:0033173	calcineurin-NFAT signaling cascade	22688515
Hgene	PPP3R1	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515

Fusion gene breakpoints across PPP3R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CBWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A4A1	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+

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Fusion Gene ORF analysis for PPP3R1-CBWD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000409377	ENST00000259199	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
Frame-shift	ENST00000409377	ENST00000416503	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
Frame-shift	ENST00000409377	ENST00000433343	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000234310	ENST00000259199	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000234310	ENST00000416503	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000234310	ENST00000433343	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000409752	ENST00000259199	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000409752	ENST00000416503	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+
In-frame	ENST00000409752	ENST00000433343	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000234310	PPP3R1	chr2	68413599	-	ENST00000259199	CBWD2	chr2	114251333	+	1687	869	404	1240	278
ENST00000234310	PPP3R1	chr2	68413599	-	ENST00000416503	CBWD2	chr2	114251333	+	1669	869	404	1240	278
ENST00000234310	PPP3R1	chr2	68413599	-	ENST00000433343	CBWD2	chr2	114251333	+	1669	869	404	1240	278
ENST00000409752	PPP3R1	chr2	68413599	-	ENST00000259199	CBWD2	chr2	114251333	+	1462	644	59	1015	318
ENST00000409752	PPP3R1	chr2	68413599	-	ENST00000416503	CBWD2	chr2	114251333	+	1444	644	59	1015	318
ENST00000409752	PPP3R1	chr2	68413599	-	ENST00000433343	CBWD2	chr2	114251333	+	1444	644	59	1015	318

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000234310	ENST00000259199	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000554731	0.99944526
ENST00000234310	ENST00000416503	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000659369	0.9993406
ENST00000234310	ENST00000433343	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000659369	0.9993406
ENST00000409752	ENST00000259199	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000424977	0.9995751
ENST00000409752	ENST00000416503	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000449158	0.99955076
ENST00000409752	ENST00000433343	PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	0.000449158	0.99955076

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Fusion Genomic Features for PPP3R1-CBWD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	6.65E-09	1
PPP3R1	chr2	68413599	-	CBWD2	chr2	114251333	+	6.65E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3R1-CBWD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:68413599/chr2:114251333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CBWD2 Q8IUF1
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

100_111

155

171.0

Calcium binding

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

141_152

155

171.0

Calcium binding

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

31_42

155

171.0

Calcium binding

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

63_74

155

171.0

Calcium binding

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

18_51

155

171.0

Domain

EF-hand 1

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

50_85

155

171.0

Domain

EF-hand 2

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

87_122

155

171.0

Domain

EF-hand 3

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

131_136

155

171.0

Region

Calcineurin A binding

Tgene

CBWD2

chr2:68413599

chr2:114251333

ENST00000259199

274_377

272

396.0

Domain

Note=CobW C-terminal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP3R1

chr2:68413599

chr2:114251333

ENST00000234310

128_163

155

171.0

Domain

EF-hand 4

Tgene

CBWD2

chr2:68413599

chr2:114251333

ENST00000259199

31_34

272

396.0

Compositional bias

Note=Poly-Glu

Tgene

CBWD2

chr2:68413599

chr2:114251333

ENST00000259199

110_114

272

396.0

Nucleotide binding

ATP

Tgene

CBWD2

chr2:68413599

chr2:114251333

ENST00000259199

203_206

272

396.0

Nucleotide binding

ATP

Tgene

CBWD2

chr2:68413599

chr2:114251333

ENST00000259199

49_56

272

396.0

Nucleotide binding

ATP

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Fusion Gene Sequence for PPP3R1-CBWD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68162_68162_1_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000259199_length(transcript)=1687nt_BP=869nt
TGCCTTGAGGTTGCGGGTCAGCGCGAGCCGCTGCAGTGAGTCCGTCACGGCTCCGGCGCGAGCGCGAGGCTGCAGCCCCCGAGTTTCCCG
GCCGTCTTCGCCCCCTCTCCCCCTCCTTTCTTCTTCTCTGCCTCTCCTGCCTCTCGCCGCTGCTCCTCCCGCGCTCTCCGGCTCTGAATC
TCGACCTTAATTTATTTCCCCCTACCCTGCCCGCTCCCTCGCGTGCCCAATCGCCCGGCCGGCGCGGGCCCCGCGGCGCCGCCTCCCCTC
CCCCACGCGCGCCCCCTCCCCGCCGGCGACCCGAGGGCCGCAGCTGGGCCGCCGCCGCCGTTTCCTGCGAGCCAGCCTGAGCGCAACACT
TCTCCGAGCCAGCGAGCCAGCGAGCCGCCGACCCGCCGAGCAAAATGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTG
ATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTC
TGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCA
TTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCT
ATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAA
CCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAG
GAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCCTGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGG
TCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAACAAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGA
CTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGGTCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGT
TTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATTTCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTAT
CAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTCAAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAA
AATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTACTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTT
TTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTTTGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGAT
ACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTGCAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAG

>68162_68162_1_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000259199_length(amino acids)=278AA_BP=155
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQ
KLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNL
LWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTH

--------------------------------------------------------------
>68162_68162_2_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000416503_length(transcript)=1669nt_BP=869nt
TGCCTTGAGGTTGCGGGTCAGCGCGAGCCGCTGCAGTGAGTCCGTCACGGCTCCGGCGCGAGCGCGAGGCTGCAGCCCCCGAGTTTCCCG
GCCGTCTTCGCCCCCTCTCCCCCTCCTTTCTTCTTCTCTGCCTCTCCTGCCTCTCGCCGCTGCTCCTCCCGCGCTCTCCGGCTCTGAATC
TCGACCTTAATTTATTTCCCCCTACCCTGCCCGCTCCCTCGCGTGCCCAATCGCCCGGCCGGCGCGGGCCCCGCGGCGCCGCCTCCCCTC
CCCCACGCGCGCCCCCTCCCCGCCGGCGACCCGAGGGCCGCAGCTGGGCCGCCGCCGCCGTTTCCTGCGAGCCAGCCTGAGCGCAACACT
TCTCCGAGCCAGCGAGCCAGCGAGCCGCCGACCCGCCGAGCAAAATGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTG
ATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTC
TGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCA
TTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCT
ATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAA
CCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAG
GAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCCTGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGG
TCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAACAAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGA
CTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGGTCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGT
TTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATTTCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTAT
CAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTCAAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAA
AATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTACTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTT
TTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTTTGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGAT
ACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTGCAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAG

>68162_68162_2_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000416503_length(amino acids)=278AA_BP=155
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQ
KLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNL
LWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTH

--------------------------------------------------------------
>68162_68162_3_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000433343_length(transcript)=1669nt_BP=869nt
TGCCTTGAGGTTGCGGGTCAGCGCGAGCCGCTGCAGTGAGTCCGTCACGGCTCCGGCGCGAGCGCGAGGCTGCAGCCCCCGAGTTTCCCG
GCCGTCTTCGCCCCCTCTCCCCCTCCTTTCTTCTTCTCTGCCTCTCCTGCCTCTCGCCGCTGCTCCTCCCGCGCTCTCCGGCTCTGAATC
TCGACCTTAATTTATTTCCCCCTACCCTGCCCGCTCCCTCGCGTGCCCAATCGCCCGGCCGGCGCGGGCCCCGCGGCGCCGCCTCCCCTC
CCCCACGCGCGCCCCCTCCCCGCCGGCGACCCGAGGGCCGCAGCTGGGCCGCCGCCGCCGTTTCCTGCGAGCCAGCCTGAGCGCAACACT
TCTCCGAGCCAGCGAGCCAGCGAGCCGCCGACCCGCCGAGCAAAATGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTG
ATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTC
TGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCA
TTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCT
ATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAA
CCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAG
GAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCCTGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGG
TCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAACAAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGA
CTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGGTCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGT
TTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATTTCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTAT
CAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTCAAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAA
AATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTACTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTT
TTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTTTGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGAT
ACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTGCAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAG

>68162_68162_3_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000234310_CBWD2_chr2_114251333_ENST00000433343_length(amino acids)=278AA_BP=155
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQ
KLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNL
LWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTH

--------------------------------------------------------------
>68162_68162_4_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000259199_length(transcript)=1462nt_BP=644nt
TTGGCATCTCAGGTGCCTGGGAGCCCTTTCTCAACCACACCCTGGAGTAGGGGGCTAGCTTGCATCCCTGCGTTCTCCTCATTACAAAAA
AGAATTCTGAGAAGGAAGGTGATCTATTCCCTATGCAACCTCAGTGTCCACTGAGAAGGGAATCTTGTGGTATGGAACTATGTGGCAAAA
AGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTGATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTG
ATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATA
TATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGA
AATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGG
GGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTG
AAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAGGAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCC
TGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGGTCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAAC
AAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGACTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGG
TCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATT
TCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTATCAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTC
AAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAAAATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTA
CTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTTTTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTT
TGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGATACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTG
CAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAGTAAGTGTCACCATTTTATGACATGAAATAAAAGGTTATGACTGTT

>68162_68162_4_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000259199_length(amino acids)=318AA_BP=195
MHPCVLLITKKNSEKEGDLFPMQPQCPLRRESCGMELCGKKGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQ
QNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINA
DKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSW

--------------------------------------------------------------
>68162_68162_5_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000416503_length(transcript)=1444nt_BP=644nt
TTGGCATCTCAGGTGCCTGGGAGCCCTTTCTCAACCACACCCTGGAGTAGGGGGCTAGCTTGCATCCCTGCGTTCTCCTCATTACAAAAA
AGAATTCTGAGAAGGAAGGTGATCTATTCCCTATGCAACCTCAGTGTCCACTGAGAAGGGAATCTTGTGGTATGGAACTATGTGGCAAAA
AGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTGATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTG
ATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATA
TATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGA
AATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGG
GGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTG
AAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAGGAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCC
TGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGGTCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAAC
AAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGACTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGG
TCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATT
TCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTATCAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTC
AAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAAAATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTA
CTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTTTTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTT
TGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGATACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTG
CAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAGTAAGTGTCACCATTTTATGACATGAAATAAAAGGTTATGACTGTT

>68162_68162_5_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000416503_length(amino acids)=318AA_BP=195
MHPCVLLITKKNSEKEGDLFPMQPQCPLRRESCGMELCGKKGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQ
QNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINA
DKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSW

--------------------------------------------------------------
>68162_68162_6_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000433343_length(transcript)=1444nt_BP=644nt
TTGGCATCTCAGGTGCCTGGGAGCCCTTTCTCAACCACACCCTGGAGTAGGGGGCTAGCTTGCATCCCTGCGTTCTCCTCATTACAAAAA
AGAATTCTGAGAAGGAAGGTGATCTATTCCCTATGCAACCTCAGTGTCCACTGAGAAGGGAATCTTGTGGTATGGAACTATGTGGCAAAA
AGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTGATGCGGATGAAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTG
ATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGATA
TATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCGTCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGA
AATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGG
GGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAAATGCAGATAAGGATGGAGATGGAAGAATATCCTTTG
AAGAATTCTGTGCTAGTATTGTTACAATCACATTTGAAGTACCAGGAAATGCAAAGGAAGAACATCTTAATATGTTTATTCAGAATCTCC
TGTGGGAAAAGAATGTGAGAAACAAGGACAATCACTGCATGGAGGTCATAAGGCTGAAGGGATTGGTGTCAATCAAAGACAAATCACAAC
AAGTGATTGTCCAGGGTGTCCATGAGCTCTATGATCTGGAGGAGACTCCAGTGAGCTGGAAGGATGACACTGAGAGAACAAATCGATTGG
TCCTCCTTGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACATT
TCAAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTATCAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTC
AAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAAAATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCGGTA
CTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTTTTTTAAAGAATGGTATTTCACAAAAATGTCTTTTGAAATTGGCTT
TGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGATACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTG
CAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAGTAAGTGTCACCATTTTATGACATGAAATAAAAGGTTATGACTGTT

>68162_68162_6_PPP3R1-CBWD2_PPP3R1_chr2_68413599_ENST00000409752_CBWD2_chr2_114251333_ENST00000433343_length(amino acids)=318AA_BP=195
MHPCVLLITKKNSEKEGDLFPMQPQCPLRRESCGMELCGKKGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQ
QNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINA
DKDGDGRISFEEFCASIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSW

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP3R1-CBWD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPP3R1-CBWD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPP3R1-CBWD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source