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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP3R1-WDPCP (FusionGDB2 ID:68167)

Fusion Gene Summary for PPP3R1-WDPCP

Fusion gene summary

Fusion gene information	Fusion gene name: PPP3R1-WDPCP
	Fusion gene ID: 68167
		Hgene	Tgene
	Gene symbol	PPP3R1	WDPCP
	Gene ID	5534	51057
	Gene name	protein phosphatase 3 regulatory subunit B, alpha	WD repeat containing planar cell polarity effector
	Synonyms	CALNB1\|CNB\|CNB1	BBS15\|C2orf86\|CHDTHP\|CPLANE5\|FRITZ\|FRTZ
	Cytomap	2p14	2p15
	Type of gene	protein-coding	protein-coding
	Description	calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I	WD repeat-containing and planar cell polarity effector protein fritz homologBardet-Biedl syndrome 15 proteinWD repeat-containing protein C2orf86ciliogenesis and planar polarity effector 5
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000234310, ENST00000409377, ENST00000409752,	ENST00000409835, ENST00000272321, ENST00000398544, ENST00000409120, ENST00000409199, ENST00000409562,
Fusion gene scores	* DoF score	10 X 7 X 8=560	6 X 5 X 3=90
	# samples	13	6
	** MAII score	log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPP3R1 [Title/Abstract] AND WDPCP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP3R1(68444224)-WDPCP(63631792), # samples:1
Anticipated loss of major functional domain due to fusion event.	PPP3R1-WDPCP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP3R1	GO:0033173	calcineurin-NFAT signaling cascade	22688515
Hgene	PPP3R1	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515

Fusion gene breakpoints across PPP3R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WDPCP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-M7-A721-01A	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-

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Fusion Gene ORF analysis for PPP3R1-WDPCP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000234310	ENST00000409835	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
5CDS-5UTR	ENST00000409377	ENST00000409835	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
5CDS-5UTR	ENST00000409752	ENST00000409835	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000234310	ENST00000272321	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000234310	ENST00000398544	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000234310	ENST00000409120	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000234310	ENST00000409199	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000234310	ENST00000409562	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000409752	ENST00000272321	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000409752	ENST00000398544	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000409752	ENST00000409120	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000409752	ENST00000409199	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
Frame-shift	ENST00000409752	ENST00000409562	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
In-frame	ENST00000409377	ENST00000272321	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
In-frame	ENST00000409377	ENST00000398544	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
In-frame	ENST00000409377	ENST00000409120	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
In-frame	ENST00000409377	ENST00000409199	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-
In-frame	ENST00000409377	ENST00000409562	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000409377	PPP3R1	chr2	68444224	-	ENST00000272321	WDPCP	chr2	63631792	-	2237	198	162	1613	483
ENST00000409377	PPP3R1	chr2	68444224	-	ENST00000409199	WDPCP	chr2	63631792	-	2218	198	162	1613	483
ENST00000409377	PPP3R1	chr2	68444224	-	ENST00000409120	WDPCP	chr2	63631792	-	1806	198	162	1613	483
ENST00000409377	PPP3R1	chr2	68444224	-	ENST00000398544	WDPCP	chr2	63631792	-	1789	198	162	1613	483
ENST00000409377	PPP3R1	chr2	68444224	-	ENST00000409562	WDPCP	chr2	63631792	-	2670	198	162	1229	355

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409377	ENST00000272321	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-	0.001424453	0.99857557
ENST00000409377	ENST00000409199	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-	0.001615159	0.99838483
ENST00000409377	ENST00000409120	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-	0.002713514	0.99728644
ENST00000409377	ENST00000398544	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-	0.002424739	0.9975752
ENST00000409377	ENST00000409562	PPP3R1	chr2	68444224	-	WDPCP	chr2	63631792	-	0.004103369	0.9958967

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Fusion Genomic Features for PPP3R1-WDPCP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP3R1-WDPCP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:68444224/chr2:63631792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000272321

326_374

275

747.0

Repeat

Note=WD 1

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000272321

375_414

275

747.0

Repeat

Note=WD 2

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000398544

326_374

116

588.0

Repeat

Note=WD 1

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000398544

375_414

116

588.0

Repeat

Note=WD 2

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000409562

326_374

275

619.0

Repeat

Note=WD 1

Tgene

WDPCP

chr2:68444224

chr2:63631792

ENST00000409562

375_414

275

619.0

Repeat

Note=WD 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

100_111

171.0

Calcium binding

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

141_152

171.0

Calcium binding

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

31_42

171.0

Calcium binding

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

63_74

171.0

Calcium binding

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

128_163

171.0

Domain

EF-hand 4

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

18_51

171.0

Domain

EF-hand 1

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

50_85

171.0

Domain

EF-hand 2

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

87_122

171.0

Domain

EF-hand 3

Hgene

PPP3R1

chr2:68444224

chr2:63631792

ENST00000234310

131_136

171.0

Region

Calcineurin A binding

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Fusion Gene Sequence for PPP3R1-WDPCP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68167_68167_1_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000272321_length(transcript)=2237nt_BP=198nt
AGTCGTTAGTTTCCTCTTTGTAATCAAGAGTTGTATACACAGTAGAGAAAGTTCAGAGTGCTATTCCGCGTATATCAGATACTCCATCAT
GCGATTCAGTTATTAGGCTTTCTCTAAAAGTCTTTGAACAGTTGTCAGAAGACTTAAACTGGTTGACGGGAAATGAGGCAAGTTATCCTT
TGGAAATGTGCTCACACTGTTCTGAGTTCTGTCCGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTG
TTCACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAATGCATTCGGAATAAAATCCAGTGTGTG
TCAGTCACCAGAATACCACTAAAGTCAAAGGCCATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCT
TCGCTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCTTCATTAATAAGCTGCCACCCAAGTGGT
GCCATTCTGCTAGTTGGCAGCAACCAAGGGGAGTTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGAC
CGCTTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAAATGCAATGGATAGCTCCTCAGGTTGTT
TCTCAGAAGGGTGAAGGTAGTGATATCTATGATCTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAGGC
GTCTTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAGATCTATGAGGCAATAAACATCCTGAGC
AGCATGAACTGGGACACTCTGGGCCACCAGTGCTTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAG
AGAGAAGCACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGATTCCACTATATTGGAATATAGAGATCAA
ATCAGCAAATATGCAAGGAGATTCTTCCATCACTTGCTCAGGTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCT
CGTGACCTCTTTATGGATATTCATTACCTTGCACTAGATAAAGGTGAATTGGCACTAGCTGAAGTGGCAAGAAAAAGAGCTAGTGACATT
GATGCAGAATCAATAACCTCTGGGGTTGAACTCCTGGGACCCTTGGACAGAGGGGATATGCTAAATGAAGCATTTATTGGCCTGTCTTTA
GCACCTCAAGGAGAAGACTCATTTCCAGATAACCTCCCTCCCTCTTGCCCAACCCACAGACATATTTTACAACAAAGAATACTGAATGGC
TCTTCTAACAGACAAATAATTGACAGAAGGAATGAACTTGAAAAAGACATCTGTTCTGGATTTTTGATGACTAATACCTGTAATGCAGAA
GACGGAGAACTGAGAGAAGACGGCAGAGAACAGGAAATCAGAGATGGTGGTTCTCTCAAAATGATTCACTTTGGTCTGGTGTAAACATTA
AGAAAAAAAGAAAACTGCCTTCTTCATATCTAAACTTTTCATGGCCTGATACAGACTTAAAATCCCCCGTGTGGATTTTTAACAAGAGAC
AGTATGAATCATATAAATTAGTTAAGAGTTTTGAGTTGAGTGTTTGTTTTCAAAATAAAGTTTTATTATTTCAAAAACATGCAGCATAAC
AGCAAAGTGATCGTAAGTAAAAGTCTTCAACCTACTTATTTTCAATAATGTAAAATTTTGAAAGTGTCTTAAATTGTATGTTAATTAGGT
GCTACAAAAATAGAATATTTAAACTTTGTTCTCCCAGGTACTTTAAAAAAGGGGCAGTAGGGGGCAGGCATAGTGCTCATGCCTGTAGTC
CCAGTGCTTTAGGAGGCCAAGGCTGAAGGATCACTTGAGCCCAGGAGTTCAAGACTAGCCTGTGCAACATAGTGAAACGCTGTCTCTAGA
AAAAATTTTAAAAATTAGCCAGGCATGGTGGTACATGCTTGTGAAGCTGAGGCAGAAGAATTGCTTGAGCCCAGGAGTTCAAGGCTACAG

>68167_68167_1_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000272321_length(amino acids)=483AA_BP=12
MRQVILWKCAHTVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLI
LGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQW
IAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLR
QKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVAR
KRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMT

--------------------------------------------------------------
>68167_68167_2_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000398544_length(transcript)=1789nt_BP=198nt
AGTCGTTAGTTTCCTCTTTGTAATCAAGAGTTGTATACACAGTAGAGAAAGTTCAGAGTGCTATTCCGCGTATATCAGATACTCCATCAT
GCGATTCAGTTATTAGGCTTTCTCTAAAAGTCTTTGAACAGTTGTCAGAAGACTTAAACTGGTTGACGGGAAATGAGGCAAGTTATCCTT
TGGAAATGTGCTCACACTGTTCTGAGTTCTGTCCGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTG
TTCACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAATGCATTCGGAATAAAATCCAGTGTGTG
TCAGTCACCAGAATACCACTAAAGTCAAAGGCCATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCT
TCGCTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCTTCATTAATAAGCTGCCACCCAAGTGGT
GCCATTCTGCTAGTTGGCAGCAACCAAGGGGAGTTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGAC
CGCTTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAAATGCAATGGATAGCTCCTCAGGTTGTT
TCTCAGAAGGGTGAAGGTAGTGATATCTATGATCTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAGGC
GTCTTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAGATCTATGAGGCAATAAACATCCTGAGC
AGCATGAACTGGGACACTCTGGGCCACCAGTGCTTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAG
AGAGAAGCACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGATTCCACTATATTGGAATATAGAGATCAA
ATCAGCAAATATGCAAGGAGATTCTTCCATCACTTGCTCAGGTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCT
CGTGACCTCTTTATGGATATTCATTACCTTGCACTAGATAAAGGTGAATTGGCACTAGCTGAAGTGGCAAGAAAAAGAGCTAGTGACATT
GATGCAGAATCAATAACCTCTGGGGTTGAACTCCTGGGACCCTTGGACAGAGGGGATATGCTAAATGAAGCATTTATTGGCCTGTCTTTA
GCACCTCAAGGAGAAGACTCATTTCCAGATAACCTCCCTCCCTCTTGCCCAACCCACAGACATATTTTACAACAAAGAATACTGAATGGC
TCTTCTAACAGACAAATAATTGACAGAAGGAATGAACTTGAAAAAGACATCTGTTCTGGATTTTTGATGACTAATACCTGTAATGCAGAA
GACGGAGAACTGAGAGAAGACGGCAGAGAACAGGAAATCAGAGATGGTGGTTCTCTCAAAATGATTCACTTTGGTCTGGTGTAAACATTA
AGAAAAAAAGAAAACTGCCTTCTTCATATCTAAACTTTTCATGGCCTGATACAGACTTAAAATCCCCCGTGTGGATTTTTAACAAGAGAC

>68167_68167_2_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000398544_length(amino acids)=483AA_BP=12
MRQVILWKCAHTVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLI
LGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQW
IAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLR
QKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVAR
KRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMT

--------------------------------------------------------------
>68167_68167_3_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409120_length(transcript)=1806nt_BP=198nt
AGTCGTTAGTTTCCTCTTTGTAATCAAGAGTTGTATACACAGTAGAGAAAGTTCAGAGTGCTATTCCGCGTATATCAGATACTCCATCAT
GCGATTCAGTTATTAGGCTTTCTCTAAAAGTCTTTGAACAGTTGTCAGAAGACTTAAACTGGTTGACGGGAAATGAGGCAAGTTATCCTT
TGGAAATGTGCTCACACTGTTCTGAGTTCTGTCCGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTG
TTCACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAATGCATTCGGAATAAAATCCAGTGTGTG
TCAGTCACCAGAATACCACTAAAGTCAAAGGCCATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCT
TCGCTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCTTCATTAATAAGCTGCCACCCAAGTGGT
GCCATTCTGCTAGTTGGCAGCAACCAAGGGGAGTTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGAC
CGCTTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAAATGCAATGGATAGCTCCTCAGGTTGTT
TCTCAGAAGGGTGAAGGTAGTGATATCTATGATCTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAGGC
GTCTTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAGATCTATGAGGCAATAAACATCCTGAGC
AGCATGAACTGGGACACTCTGGGCCACCAGTGCTTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAG
AGAGAAGCACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGATTCCACTATATTGGAATATAGAGATCAA
ATCAGCAAATATGCAAGGAGATTCTTCCATCACTTGCTCAGGTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCT
CGTGACCTCTTTATGGATATTCATTACCTTGCACTAGATAAAGGTGAATTGGCACTAGCTGAAGTGGCAAGAAAAAGAGCTAGTGACATT
GATGCAGAATCAATAACCTCTGGGGTTGAACTCCTGGGACCCTTGGACAGAGGGGATATGCTAAATGAAGCATTTATTGGCCTGTCTTTA
GCACCTCAAGGAGAAGACTCATTTCCAGATAACCTCCCTCCCTCTTGCCCAACCCACAGACATATTTTACAACAAAGAATACTGAATGGC
TCTTCTAACAGACAAATAATTGACAGAAGGAATGAACTTGAAAAAGACATCTGTTCTGGATTTTTGATGACTAATACCTGTAATGCAGAA
GACGGAGAACTGAGAGAAGACGGCAGAGAACAGGAAATCAGAGATGGTGGTTCTCTCAAAATGATTCACTTTGGTCTGGTGTAAACATTA
AGAAAAAAAGAAAACTGCCTTCTTCATATCTAAACTTTTCATGGCCTGATACAGACTTAAAATCCCCCGTGTGGATTTTTAACAAGAGAC
AGTATGAATCATATAAATTAGTTAAGAGTTTTGAGTTGAGTGTTTGTTTTCAAAATAAAGTTTTATTATTTCAAAAACATGCAGCATAAC

>68167_68167_3_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409120_length(amino acids)=483AA_BP=12
MRQVILWKCAHTVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLI
LGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQW
IAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLR
QKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVAR
KRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMT

--------------------------------------------------------------
>68167_68167_4_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409199_length(transcript)=2218nt_BP=198nt
AGTCGTTAGTTTCCTCTTTGTAATCAAGAGTTGTATACACAGTAGAGAAAGTTCAGAGTGCTATTCCGCGTATATCAGATACTCCATCAT
GCGATTCAGTTATTAGGCTTTCTCTAAAAGTCTTTGAACAGTTGTCAGAAGACTTAAACTGGTTGACGGGAAATGAGGCAAGTTATCCTT
TGGAAATGTGCTCACACTGTTCTGAGTTCTGTCCGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTG
TTCACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAATGCATTCGGAATAAAATCCAGTGTGTG
TCAGTCACCAGAATACCACTAAAGTCAAAGGCCATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCT
TCGCTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCTTCATTAATAAGCTGCCACCCAAGTGGT
GCCATTCTGCTAGTTGGCAGCAACCAAGGGGAGTTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGAC
CGCTTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAAATGCAATGGATAGCTCCTCAGGTTGTT
TCTCAGAAGGGTGAAGGTAGTGATATCTATGATCTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAGGC
GTCTTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAGATCTATGAGGCAATAAACATCCTGAGC
AGCATGAACTGGGACACTCTGGGCCACCAGTGCTTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAG
AGAGAAGCACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGATTCCACTATATTGGAATATAGAGATCAA
ATCAGCAAATATGCAAGGAGATTCTTCCATCACTTGCTCAGGTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCT
CGTGACCTCTTTATGGATATTCATTACCTTGCACTAGATAAAGGTGAATTGGCACTAGCTGAAGTGGCAAGAAAAAGAGCTAGTGACATT
GATGCAGAATCAATAACCTCTGGGGTTGAACTCCTGGGACCCTTGGACAGAGGGGATATGCTAAATGAAGCATTTATTGGCCTGTCTTTA
GCACCTCAAGGAGAAGACTCATTTCCAGATAACCTCCCTCCCTCTTGCCCAACCCACAGACATATTTTACAACAAAGAATACTGAATGGC
TCTTCTAACAGACAAATAATTGACAGAAGGAATGAACTTGAAAAAGACATCTGTTCTGGATTTTTGATGACTAATACCTGTAATGCAGAA
GACGGAGAACTGAGAGAAGACGGCAGAGAACAGGAAATCAGAGATGGTGGTTCTCTCAAAATGATTCACTTTGGTCTGGTGTAAACATTA
AGAAAAAAAGAAAACTGCCTTCTTCATATCTAAACTTTTCATGGCCTGATACAGACTTAAAATCCCCCGTGTGGATTTTTAACAAGAGAC
AGTATGAATCATATAAATTAGTTAAGAGTTTTGAGTTGAGTGTTTGTTTTCAAAATAAAGTTTTATTATTTCAAAAACATGCAGCATAAC
AGCAAAGTGATCGTAAGTAAAAGTCTTCAACCTACTTATTTTCAATAATGTAAAATTTTGAAAGTGTCTTAAATTGTATGTTAATTAGGT
GCTACAAAAATAGAATATTTAAACTTTGTTCTCCCAGGTACTTTAAAAAAGGGGCAGTAGGGGGCAGGCATAGTGCTCATGCCTGTAGTC
CCAGTGCTTTAGGAGGCCAAGGCTGAAGGATCACTTGAGCCCAGGAGTTCAAGACTAGCCTGTGCAACATAGTGAAACGCTGTCTCTAGA
AAAAATTTTAAAAATTAGCCAGGCATGGTGGTACATGCTTGTGAAGCTGAGGCAGAAGAATTGCTTGAGCCCAGGAGTTCAAGGCTACAG

>68167_68167_4_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409199_length(amino acids)=483AA_BP=12
MRQVILWKCAHTVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLI
LGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQW
IAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLR
QKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVAR
KRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMT

--------------------------------------------------------------
>68167_68167_5_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409562_length(transcript)=2670nt_BP=198nt
AGTCGTTAGTTTCCTCTTTGTAATCAAGAGTTGTATACACAGTAGAGAAAGTTCAGAGTGCTATTCCGCGTATATCAGATACTCCATCAT
GCGATTCAGTTATTAGGCTTTCTCTAAAAGTCTTTGAACAGTTGTCAGAAGACTTAAACTGGTTGACGGGAAATGAGGCAAGTTATCCTT
TGGAAATGTGCTCACACTGTTCTGAGTTCTGTCCGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTG
TTCACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAATGCATTCGGAATAAAATCCAGTGTGTG
TCAGTCACCAGAATACCACTAAAGTCAAAGGCCATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCT
TCGCTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCTTCATTAATAAGCTGCCACCCAAGTGGT
GCCATTCTGCTAGTTGGCAGCAACCAAGGGGAGTTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGAC
CGCTTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAAATGCAATGGATAGCTCCTCAGGTTGTT
TCTCAGAAGGGTGAAGGTAGTGATATCTATGATCTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAGGC
GTCTTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAGATCTATGAGGCAATAAACATCCTGAGC
AGCATGAACTGGGACACTCTGGGCCACCAGTGCTTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAG
AGAGAAGCACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGATTCCACTATATTGGAATATAGAGATCAA
ATCAGCAAATATGCAAGGAGATTCTTCCATCACTTGCTCAGGTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCT
CGTGACCTCTTTATGGCATCATGCTACCTGACTTCAAACTACACTACAAGGCTACAGTAACCAAAACAGCATGGTACTGGTCCCAAAACA
GAGATATAGACCAATGGAACAGAACAGAGCCCTCAGAAATAATGCCGCATATCTACAACTATCTGATCTTTGACAAACCTGACAAAAACA
AGAAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGAAACTGGATCCCTTCCTTA
CACCTTATACAAAAATTAATTCAAGATGGATTAAAGACTTAAATGTTAGACCTAAAACCATAAAAGCCCTAGAAGAAAACCTAGGCAATA
CCATTCAGGACACAGGCATGGGCAAGGACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGATCTAA
TTAAACTAAAGAGCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGGACAGGCAACCTACAGAATGGGAGAAAATTTTTGCAACCTACT
CATCTGACAAAGGGCTAATATCCAGAATCTACAAAGAACTCAAATAAATTTACAAGAAAAAAACAAACAACCCCATCCAAAAGTGGGCAA
AGGATATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAAAAAACACATGAAAAAATGCTCATCATCACTGGCCATCAGAGAAA
TGCAAATCAAAACCACAATGAGATACCGTCTCACACCAGTTAGAATGGTGATCATTAAAAAGTCAGCAAACAACATGTGCTGGAGAGGAT
GTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATC
TGGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGATTATAAATCATGCTGCTATAAAGACACATGCA
CACGTATGTTTATTGCAGCACTATTCACAATAGCTAAGACTTGGAACCAACCTAAGTGTCCAACAATGATAGACTGGGTTAAGAAAATGT
GGCACATATACACCATGGAATACTATGCAGCCATAAAAAAGGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAGCTGGAAACCATCA
TTCTCAGCAAACTACCGCAAGGACAAAAAACCAAACACCATATGTTCTCACTCATAGGTGGGAATGGAACAATGAGAACACATGGACACA
AGAAGGGGAACATCACACACCGGGGACTGTTGTGTGGTGGGGGTAGGGGGGAGGGATAGCATTAGGAGATATACCTAATGCTAAATGACG
AGTTAATGGGTGCAGCACACCACCATGGCACATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAAAACTTAAAGTAA

>68167_68167_5_PPP3R1-WDPCP_PPP3R1_chr2_68444224_ENST00000409377_WDPCP_chr2_63631792_ENST00000409562_length(amino acids)=355AA_BP=12
MRQVILWKCAHTVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLI
LGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQW
IAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP3R1-WDPCP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPP3R1-WDPCP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPP3R1-WDPCP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source