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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP4R1-ITGB6 (FusionGDB2 ID:68186)

Fusion Gene Summary for PPP4R1-ITGB6

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP4R1-ITGB6
Fusion gene ID: 68186
HgeneTgene
Gene symbol

PPP4R1

ITGB6

Gene ID

9989

3694

Gene nameprotein phosphatase 4 regulatory subunit 1integrin subunit beta 6
SynonymsMEG1|PP4(Rmeg)|PP4R1AI1H
Cytomap

18p11.22

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4integrin beta-6integrin, beta 6
Modification date2020031320200313
UniProtAcc.

P18564

Ensembl transtripts involved in fusion geneENST00000400555, ENST00000400556, 
ENST00000580583, 		ENST00000409872, 
ENST00000409967, ENST00000428609, 
ENST00000485635, ENST00000283249, 
Fusion gene scores* DoF score13 X 13 X 9=15218 X 6 X 8=384
# samples 1410
** MAII scorelog2(14/1521*10)=-3.44152142077953
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/384*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP4R1 [Title/Abstract] AND ITGB6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP4R1(9614224)-ITGB6(160968710), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneITGB6

GO:0033627

cell adhesion mediated by integrin

17158881

TgeneITGB6

GO:1901388

regulation of transforming growth factor beta activation

22278742


check buttonFusion gene breakpoints across PPP4R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGB6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315472PPP4R1chr18

9614224

-ITGB6chr2

160968710

-


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Fusion Gene ORF analysis for PPP4R1-ITGB6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000400555ENST00000409872PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400555ENST00000409967PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400555ENST00000428609PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400555ENST00000485635PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400556ENST00000409872PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400556ENST00000409967PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400556ENST00000428609PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
5CDS-intronENST00000400556ENST00000485635PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
In-frameENST00000400555ENST00000283249PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
In-frameENST00000400556ENST00000283249PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
intron-3CDSENST00000580583ENST00000283249PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
intron-intronENST00000580583ENST00000409872PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
intron-intronENST00000580583ENST00000409967PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
intron-intronENST00000580583ENST00000428609PPP4R1chr18

9614224

-ITGB6chr2

160968710

-
intron-intronENST00000580583ENST00000485635PPP4R1chr18

9614224

-ITGB6chr2

160968710

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400556PPP4R1chr189614224-ENST00000283249ITGB6chr2160968710-258212674511145
ENST00000400555PPP4R1chr189614224-ENST00000283249ITGB6chr2160968710-259313785522145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400556ENST00000283249PPP4R1chr189614224-ITGB6chr2160968710-0.0046551630.9953448
ENST00000400555ENST00000283249PPP4R1chr189614224-ITGB6chr2160968710-0.0056918810.9943082

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Fusion Genomic Features for PPP4R1-ITGB6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP4R1-ITGB6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:9614224/chr2:160968710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGB6

P18564

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:28117447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:24367260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115731_788660789.0Topological domainCytoplasmic
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216731_788660789.0Topological domainCytoplasmic
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115710_730660789.0TransmembraneHelical
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216710_730660789.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220127_16417934.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220168_20617934.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-2201_2517934.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220208_24617934.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220248_28517934.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-22026_6317934.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220287_32417934.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220505_54217934.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220568_60617934.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-22065_8117934.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220698_73417934.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220799_83717934.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-22082_11917934.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400555-220861_89817934.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220127_16417951.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220168_20617951.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-2201_2517951.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220208_24617951.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220248_28517951.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-22026_6317951.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220287_32417951.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220505_54217951.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220568_60617951.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-22065_8117951.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220698_73417951.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220799_83717951.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-22082_11917951.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9614224chr2:160968710ENST00000400556-220861_89817951.0RepeatNote=HEAT 14
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115131_371660789.0DomainNote=VWFA
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216131_371660789.0DomainNote=VWFA
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115456_619660789.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216456_619660789.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115456_501660789.0RepeatNote=I
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115502_543660789.0RepeatNote=II
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115544_582660789.0RepeatNote=III
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115583_619660789.0RepeatNote=IV
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216456_501660789.0RepeatNote=I
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216502_543660789.0RepeatNote=II
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216544_582660789.0RepeatNote=III
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216583_619660789.0RepeatNote=IV
TgeneITGB6chr18:9614224chr2:160968710ENST00000283249111522_709660789.0Topological domainExtracellular
TgeneITGB6chr18:9614224chr2:160968710ENST00000409872121622_709660789.0Topological domainExtracellular


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Fusion Gene Sequence for PPP4R1-ITGB6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68186_68186_1_PPP4R1-ITGB6_PPP4R1_chr18_9614224_ENST00000400555_ITGB6_chr2_160968710_ENST00000283249_length(transcript)=2593nt_BP=137nt
GCGCGCGTCCACCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGC
GGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGAGA
AAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAGCC
TCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTGTC
ATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGATC
CACAAGTACTTTTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCCACAGATTGCTAGAACTACTTTATGCATGA
AAAAAGTCTGTTTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTGCTTCAAAATGAGGTTGGTTTAAGATAATA
ATAGGACATCTGCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAAAATAATCAAGAAGAGAAATATCCTTAGCA
AAGAGATGACTTTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAAATCATCAAATGATTCATGGGGGCCTGATT
TGCATTTGAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGTTTTTTGTCTCGGCAAAGTCACAAAGCCCA
TATACTCACATTGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCTCTCTTAAAGGAGAATTTTTTTTAAATCTC
TGAGAAATGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTCAAATATAAGGTTGAAAGTTAAGTGTTAAT
AATTTTTGTGAATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACAAATAAGGAATAAGTAATTTATAAATTAAG
AAGTTACCTATAAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCTGAAAAACGATATTCTACACTGTTTCCTTT
TTGACTCTGAGTTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTGCACAGTCTTTTAAACCCTGTAATTGTCAT
ACCAAAGTTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCCAATAATATAAAAGGAACATGTGTTAAACA
CAATAAAATTTTAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTTTTTAATACATACTCTTTTCCCATCTATGT
AACCCAACTTGCACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAGGTAAGATTTTACTTGCAAAATACATGTGC
AAATTAGGGATCCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTATTACTCCTTTACAAAGCACTTTCGTCTCA
CTTGATCCTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTCTTCTAACTCCAAGCCATCTCCTCTTTCCA
CTGCAGGAAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATAACTGTCATTTGTTTGAAAATGTTCGAGAC
TGAACAAATAGCATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTTTATTACCTTTGATTAAATTGTAATGTGAA
GCTTTTACTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGTCACAGCAAAATCTATAAGTTTCTTCAATT
CTACAAGATAGATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGATAACTCAGGTAAATCAGACCTTTACAGAG
TACAGGGCTAGGTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATACCCTTTATGTTCCTGACTGATGCGCAGAAC
CTGGGGGAAATCTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTCCTCTACGTGGACTTACTGTTGTTTTTTTA
ATTATTATTGGAATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGGTAGAGAAGAATCTGCTCTTTCTCTGAATA
CTGTTTTGACCCCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTCACTGAAGAGTTATGTTACATGAAGATAAA

>68186_68186_1_PPP4R1-ITGB6_PPP4R1_chr18_9614224_ENST00000400555_ITGB6_chr2_160968710_ENST00000283249_length(amino acids)=145AA_BP=18
MADLSLLQEDLQEDADGYFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLL

--------------------------------------------------------------
>68186_68186_2_PPP4R1-ITGB6_PPP4R1_chr18_9614224_ENST00000400556_ITGB6_chr2_160968710_ENST00000283249_length(transcript)=2582nt_BP=126nt
CCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGCGGACCTCTCGC
TGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGAGAAAATGAATGTC
TTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAGCCTCCAAACATTC
CCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTGTCATTTCATGATC
GTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGATCCACAAGTACTT
TTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCCACAGATTGCTAGAACTACTTTATGCATGAAAAAAGTCTGT
TTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTGCTTCAAAATGAGGTTGGTTTAAGATAATAATAGGACATCT
GCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAAAATAATCAAGAAGAGAAATATCCTTAGCAAAGAGATGACT
TTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAAATCATCAAATGATTCATGGGGGCCTGATTTGCATTTGAAA
AATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGTTTTTTGTCTCGGCAAAGTCACAAAGCCCATATACTCACAT
TGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCTCTCTTAAAGGAGAATTTTTTTTAAATCTCTGAGAAATGAG
ATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTCAAATATAAGGTTGAAAGTTAAGTGTTAATAATTTTTGTGA
ATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACAAATAAGGAATAAGTAATTTATAAATTAAGAAGTTACCTAT
AAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCTGAAAAACGATATTCTACACTGTTTCCTTTTTGACTCTGAG
TTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTGCACAGTCTTTTAAACCCTGTAATTGTCATACCAAAGTTTC
TTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCCAATAATATAAAAGGAACATGTGTTAAACACAATAAAATTT
TAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTTTTTAATACATACTCTTTTCCCATCTATGTAACCCAACTTG
CACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAGGTAAGATTTTACTTGCAAAATACATGTGCAAATTAGGGAT
CCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTATTACTCCTTTACAAAGCACTTTCGTCTCACTTGATCCTCA
TAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTCTTCTAACTCCAAGCCATCTCCTCTTTCCACTGCAGGAAAC
TGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATAACTGTCATTTGTTTGAAAATGTTCGAGACTGAACAAATAG
CATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTTTATTACCTTTGATTAAATTGTAATGTGAAGCTTTTACTAG
GTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGTCACAGCAAAATCTATAAGTTTCTTCAATTCTACAAGATAG
ATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGATAACTCAGGTAAATCAGACCTTTACAGAGTACAGGGCTAG
GTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATACCCTTTATGTTCCTGACTGATGCGCAGAACCTGGGGGAAAT
CTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTCCTCTACGTGGACTTACTGTTGTTTTTTTAATTATTATTGG
AATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGGTAGAGAAGAATCTGCTCTTTCTCTGAATACTGTTTTGACC
CCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTCACTGAAGAGTTATGTTACATGAAGATAAAATGGTTTTGTC

>68186_68186_2_PPP4R1-ITGB6_PPP4R1_chr18_9614224_ENST00000400556_ITGB6_chr2_160968710_ENST00000283249_length(amino acids)=145AA_BP=18
MADLSLLQEDLQEDADGYFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLL

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Fusion Gene PPI Analysis for PPP4R1-ITGB6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneITGB6chr18:9614224chr2:160968710ENST000002832491115731_758660.3333333333334789.0HAX1
TgeneITGB6chr18:9614224chr2:160968710ENST000004098721216731_758660.3333333333334789.0HAX1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP4R1-ITGB6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP4R1-ITGB6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource