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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP5C-PDXK (FusionGDB2 ID:68228)

Fusion Gene Summary for PPP5C-PDXK

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP5C-PDXK
Fusion gene ID: 68228
HgeneTgene
Gene symbol

PPP5C

PDXK

Gene ID

5536

8566

Gene nameprotein phosphatase 5 catalytic subunitpyridoxal kinase
SynonymsPP5|PPP5|PPTC21orf124|C21orf97|HEL-S-1a|HMSN6C|PKH|PNK|PRED79
Cytomap

19q13.32

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 5PP-Tprotein phosphatase Tpyridoxal kinaseepididymis secretory sperm binding protein Li 1apyridoxal (pyridoxine, vitamin B6) kinasepyridoxamine kinasepyridoxine kinasevitamin B6 kinase
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000012443, ENST00000391919, 
ENST00000476313, ENST00000467908, 
ENST00000291565, ENST00000327574, 
ENST00000398081, ENST00000468090, 
Fusion gene scores* DoF score8 X 3 X 7=16811 X 7 X 8=616
# samples 913
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP5C [Title/Abstract] AND PDXK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP5C(46879831)-PDXK(45153949), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDXK

GO:0042823

pyridoxal phosphate biosynthetic process

9099727|10987144|17766369


check buttonFusion gene breakpoints across PPP5C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDXK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A5BYPPP5Cchr19

46879831

+PDXKchr21

45153949

+


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Fusion Gene ORF analysis for PPP5C-PDXK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000012443ENST00000476313PPP5Cchr19

46879831

+PDXKchr21

45153949

+
5CDS-3UTRENST00000391919ENST00000476313PPP5Cchr19

46879831

+PDXKchr21

45153949

+
5CDS-intronENST00000012443ENST00000467908PPP5Cchr19

46879831

+PDXKchr21

45153949

+
5CDS-intronENST00000391919ENST00000467908PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000012443ENST00000291565PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000012443ENST00000327574PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000012443ENST00000398081PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000012443ENST00000468090PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000391919ENST00000291565PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000391919ENST00000327574PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000391919ENST00000398081PPP5Cchr19

46879831

+PDXKchr21

45153949

+
In-frameENST00000391919ENST00000468090PPP5Cchr19

46879831

+PDXKchr21

45153949

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000012443PPP5Cchr1946879831+ENST00000398081PDXKchr2145153949+26997361778729349
ENST00000012443PPP5Cchr1946879831+ENST00000468090PDXKchr2145153949+77487361031503466
ENST00000012443PPP5Cchr1946879831+ENST00000291565PDXKchr2145153949+78327361031587494
ENST00000012443PPP5Cchr1946879831+ENST00000327574PDXKchr2145153949+26997361778729349
ENST00000391919PPP5Cchr1946879831+ENST00000398081PDXKchr2145153949+25856221664615349
ENST00000391919PPP5Cchr1946879831+ENST00000468090PDXKchr2145153949+7634622611389442
ENST00000391919PPP5Cchr1946879831+ENST00000291565PDXKchr2145153949+7718622611473470
ENST00000391919PPP5Cchr1946879831+ENST00000327574PDXKchr2145153949+25856221664615349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000012443ENST00000398081PPP5Cchr1946879831+PDXKchr2145153949+0.0046393880.9953607
ENST00000012443ENST00000468090PPP5Cchr1946879831+PDXKchr2145153949+0.0016983160.9983016
ENST00000012443ENST00000291565PPP5Cchr1946879831+PDXKchr2145153949+0.0014956260.9985044
ENST00000012443ENST00000327574PPP5Cchr1946879831+PDXKchr2145153949+0.0046393880.9953607
ENST00000391919ENST00000398081PPP5Cchr1946879831+PDXKchr2145153949+0.81567180.1843282
ENST00000391919ENST00000468090PPP5Cchr1946879831+PDXKchr2145153949+0.001899060.99810094
ENST00000391919ENST00000291565PPP5Cchr1946879831+PDXKchr2145153949+0.0022473520.9977526
ENST00000391919ENST00000327574PPP5Cchr1946879831+PDXKchr2145153949+0.81567180.1843282

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Fusion Genomic Features for PPP5C-PDXK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP5Cchr1946879831+PDXKchr2145153949+0.024322490.97567755
PPP5Cchr1946879831+PDXKchr2145153949+0.024322490.97567755

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP5C-PDXK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:46879831/chr21:45153949)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+41328_61211500.0RepeatNote=TPR 1
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+41362_95211500.0RepeatNote=TPR 2
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+41396_129211500.0RepeatNote=TPR 3
TgenePDXKchr19:46879831chr21:45153949ENST00000291565011150_15329313.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000291565011186_18729313.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000291565011226_22829313.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000468090010150_15329285.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000468090010186_18729285.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000468090010226_22829285.0Nucleotide bindingATP
TgenePDXKchr19:46879831chr21:45153949ENST00000291565011234_23529313.0RegionPyridoxal 5'-phosphate binding
TgenePDXKchr19:46879831chr21:45153949ENST00000468090010234_23529285.0RegionPyridoxal 5'-phosphate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+413184_499211500.0RegionNote=Catalytic
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+413303_304211500.0RegionSubstrate binding
HgenePPP5Cchr19:46879831chr21:45153949ENST00000012443+413495_499211500.0RegionRequired for autoinhibition


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Fusion Gene Sequence for PPP5C-PDXK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68228_68228_1_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000291565_length(transcript)=7832nt_BP=736nt
ACGACACTTGTGCGGCAGCGGCGGCGGCCACCCGGCGCTCCTTCGCGACGGTTCGGCCGGGTGCCGCTGGCGGCCGTTGCCAGGGTAGGG
GTCGCTTTGCGGCATGGCGATGGCGGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAA
GCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGA
GCTGAACCCCAGCAATGCCATCTACTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCAC
GCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCT
GCGAGACTACGAGACGGTGGTCAAGGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAA
GGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTA
CAGCGGACCCAAGCTTGAAGACGGCAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCG
GAAATGTGCCTACCAGGTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGG
CCAAGTGCTGAATTCAGATGAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGGTTA
TACGAGGGACAAGTCGTTCCTGGCCATGGTGGTGGACATTGTGCAGGAGCTGAAGCAGCAGAACCCCAGGCTGGTGTACGTGTGTGATCC
AGTCTTGGGTGACAAGTGGGACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCCGCTTGC
AGACATTATCACGCCCAACCAGTTTGAGGCCGAGTTACTGAGTGGCCGGAAGATCCACAGCCAGGAGGAAGCCTTGCGGGTGATGGACAT
GCTGCACTCTATGGGCCCCGACACCGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATTGTGCTGGGGAG
TCAGAGGAGGAGGAATCCCGCTGGCTCCGTGGTGATGGAACGCATCCGGATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGGCACTGG
GGACCTGTTTGCTGCCATGCTCCTGGCGTGGACACACAAGCACCCCAATAACCTCAAGGTGGCCTGTGAGAAGACCGTGTCTACCTTGCA
CCACGTTCTGCAGAGGACCATCCAGTGTGCAAAAGCCCAGGCCGGGGAAGGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCGGATGGT
GCAGAGCAAAAGGGACATCGAGGACCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGAGGGCCCCGCCGCTTGCCCGTGACACGCAGCGC
GTTGGTGTCTCCGTGTTTGTCCCTGTGAAAACATGTAACGTCTGCCTTAGAGCCATGACCGAAACTTGATATTTTTTTCTTTCATGAGTG
TCCGGCATCTGCTGGTCTTCATTGTGAAACGTGCCAGTCGTGCTTTGTGAAAAATAACAAAGTGGTCACAGAAATTTGTGATCTGAAAAC
CCGGCTCCCTTCCCCACAAGGCTCCTGGGCCTCCGGGAAGACGGGCCCCTGTTTGCCATCTCGGGGGTGTTCCCTGTGGGAGGGTGAGTG
GGTGAGGCCGAGCCTGCTGCGTGTGGAGCCTCGAGTGGGCCCTGGCTGCCACTACCGTACAGAGGCCGTGTCGCGCTGGGCTGGGCCTGG
GTGGCCTCTGTCTTTGCATCTCTGAGAAGGAGTCGGGTGGTAACGGTTGGGGTCAGGAAGAATTCTGCCAAGTATCTTTACTGTCATTCT
GACCATAGCCTCTTTGTTCCCGCATTCGAACTTTTGGTTCTTACTTTGCTGCTCGTTTAGTCCCTGGGGATTTCAGATCTTAGGCTGTTG
TTTCACCGTATGGGAGGGTTGATGTGAGCTTGCTTGGAGACACACGGTGCAGCATCAGGGACCTTCCCAGGCCCCAGCAAATTCAAGTCG
GTCTGCAGACCTCTCAGCTACCCGCGGGACCTCTTGTAACCCATCGGCATCTTCCAGGAATCCGCCGAGTGACTTGAGGAAGATGCTAAC
GCAGTAAGGTCTGTGCTGGGCCAAGAGCAGCTTTGAAGCTCCAGAGAACCACCCCGTCAGGTTCCTTGTGGAAGCTCCCCTCATCCGTGG
TGCAGCAGGCTGAGCACTGCGCGTTTGCCACGTGCTGCCCGTGACAGCACATTGAGCCACAGCATTTGTAGACAGGACAGAGGGGTGCCT
GCCCCCTGCCCCTGCTGGCACATTTAACCCTTGTCCCCTGACCTCAGTTCTGTGCCCCACCAAATGCCCAGGGGCAAGAGGCCACCCTGG
AAGCTGCCAATCTTCCAAGGTGGGTGTGGGGCACGGTGGGGGCGGGCAGCTCCCAGGCCCTTGGGCAGGCTGGGGTGACGGCAGAGGCCA
CAGCACCAGCTCTGACAAGTCCTATCATCCTCTGCTCAGCAGTGACCTCCCTGGCCCCACTTTGCCCAGAGTTTGGGGTCCCCCCAGGTA
TAGCTATAGGCGGCAGTGCCTGTCCCTGGCCTGCCTTGATTTCAGCCACACCCCTGCAGCCCTGCATCCCAGCTCTGGGGTGTGCAGAGG
TTTGTGTCTCCAGGGAACCCACGGCTGGAGAGAAATAGGGAGATGCAGGAAGTGGGGGCCCATGGGGCCCCCAAGAAGCGGACTCTCCAA
GGGGTACCCCCACCCCGCTACCTTCCCCACGGACGGGCCCCTCCTGGAGCCCATACCCTCCTGTGAGGCCATTCCAGTGTCTTCTAGAAA
GACTCGCTTGCCAGGAGTGCGTTCTTTGTTGAAAAATGCCCTGAAGCGAAAAGATGCAGGTTTATATGGAACCCCCACCCCCTCCCCCAC
TCTCCCACTCTGTTCGTTCTGAATGTCTTCACGAGCGTGCATCAGGGCGCCTGGCTCCCCCACCTCAGCCAGTGAGTCAGACACGGGTTT
CGCAGCCATGTTTCCTGGCTCCGAGGACACGGGTGGCAGGCCCGTTGCAGCCCAGAGCCACTGGTCCCTACAGGGCGCCGCCACACCAGC
AGGAAGGAGGATGGCTGTGTCCGGAGCCTGGCGGGGAGGCGGCCTCCCCAGTATGTGAGTGCAGGGATCTGCCAGAACCACCTGGCCCTC
TGTAGGGCGTTTAACTGGAAATACCCTCACTGCCAAGTGGAGACTGGGGCGTGTGCCACATTGCCAGCCACCAGGAAAGCTTTTCTTTTT
CTTTTTTTTTTTTTTTTAAACACCAAGAGCACGTATAGCATGGGGGAAAGAACCTAAATGTCTCTCTGTCCTGTGAGCTGGTGAAAAACC
CAGCATGAGAACGCAGTGTCAGGTGTGGGACTCCTTCTGCCCCTGCAGTGGGTGTTACGGGCGGTGTGCCCTGGCGAGCAAGCTTTGATT
CTTGGTTCTTTGAGCTCGTTTCAGAGGCTGAGTCCCCACATCAGCTTTAGTTCTTGGACTTCCCTGTATTAAGCAAGAATTAGGAGAATG
GCTGTCCCTGCAGGCGCCTCCCGTAAATCCTGAGCTCTCTGGCGCAATCTGAAACTTCTCTTCTGTTTTCTTTGGCTGTATCAGCCGAAC
CAGGAGAGGCCTGGGCTGCGACTAAGGAGAAAGAAATCGGGGGTTTCTGAGAGCAGATGGTGCCTTTGTGGGTGCAGGGCTTTTGTGGAA
ATTGTCAGCCTCTACGGGCAGAGTCCGGCATCCCCTCCCCAGACTGCCTGCTGTCAAACCACGGAGCAGCTGGAGCCTGCCCTGTCCACG
GCCCGTTTCCACCCGGGCATGTTCGTCTCTCCTGACTTCGGCAGAGGCCCCTGGTGGCCTTCAGTTTCAGTTTCTCATCCAGGAAGGTAA
CCTTGGGCATTGGCAGTGGGTTTCCCTATGGCTTGGATCCAGATTAGAATTGATCTTTGTTTTCACTTTCCATAGTTAATAACATGCAAA
ATAATGAGAAGAATTTATTTTAAGGTGACAGCTATACTGGTCCAACATCGCCTGCTTATTGTCAGGGTACAGAAGTTTAATACTTTCTTA
ATCCAGTTTTTCAAACTTCTCCCTGTAGACCGTAAGGATGAATTCCACAATAGGATCCTTTTTAAAATCGATTTTAAATTGTTGCCTAGT
CCTGCCAAGGTTATTATGTGCATCTGTTATTTTTCCAATACATGTAAACAGTTGCAGCATGATGCTTTGTTTAATGTCCTGTTCTTAAGC
TCGTTAGAGCCAGTTTTGAAACGTTTGGTCTTACCGTGAACGGAGGCTGGCTTGGCTTAGCCACGCTGATGAGTAAGTGAGGGATGTCTC
CATCTTGAGATCACCAGGCAAGAGAGTTGCCTGCACCAGGTAAGAGGCCAAAGCCCCTGGGGTAACAGTCCCCACCGCTACCCGAGGTAA
AACAATAAAAGCTATGTGGTTGAGCTCAGGCCTCTCGTGCCTGGTGTCAGAGAAGGCAGAGCCCACAGTAGGTGCACGGTGCAAGGCCCT
GGGAGGGCACTGGCCAGGGAAGGTGGTATAGATGGCCCTCAGATTGCGGGGCCCCGAGCAGCTCCCCACTCTGCCCGTCCACCTTCCCTG
GCTCCAGCCTCATTCTCTCTTTAGTTTAACTATGCAAAGAGAGGAGGTTGAGAGTGTTCTGGCAGCTGGAGCTCTTTTCCTTGTCCTTCC
TGCCCTCCGATGGGGCCACCTGTGTCGGGGCAGCAGTGTCCATGTTTATGGAGATCAGAGGTGTCCCCACTGTGTGGCTGGACTGTACTC
TGCTGCCCGGGTAGCCAGGAGTCTCTCCCTCTCTCCCCTGCCGCCTGCCTGGTCTCATGGGCCTCCTTCACACACCCCTCCCTGTGGATC
GCCTGCCTGGGCCCAGAGCAGGGGAACTGGAGTTTGTGAGTGAGCAGAGCAGGTTATGTGCAGACAGGGAAACGAGAACTTTGGACCTGG
CTTTCTGAGTCCAGGTGAGAGCTGTGTGGCCCCCCGATGCCACTCTGCCCGCCGGAGGGATGTGCCTGCTGAGCCTTTTCCTTCCACGCC
GCCTCTCACTGCCAGGCCAGCGGCTTCCGCTGAGACTCGCTGGAGAGGCGGCTCCCGTGTCCGTCCACCGAGCACTCAGATGGATGCTGA
TCACCAGGGCCGAGGGGGCTCCCAGAAGGACCCCAGGCCCTGGGGAGGGTGGCTGTGGGAGGCCAAGTCCACTGCCCGGAAGTCTTGTCA
GCCCTAAGCCAGGGAAGCCTGGAGCGTGGCCTGGCGGGTCTGGGTGGACACCGTCCCCACTCCGGACTCCCAGCACAGGGGAGGATACCT
GAGCCTGTATGGCCCTGTAGCCCTGGGCAGAGCTGGGCCTGTCGTGTGTTCCTGCCTGGCAGGTGCAGGTGCTGGCCATCTGCAGGTGGA
AGGAGGTGGGAATCTTGGATTTTTTGTTTTTTTTTGTTTTTTTTTTTTTGAGGTGAAGTCTCGCTCTGACACCCAGGCTGGCGTGCAGTG
GTGTGATCTCGGCTCACTGCAAACTCCGCTTCCTGGGTTCAAGTGGTTCTCCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAGGCATGC
GCCACCACGCTCAGCTGATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTGACCTCAAGTG
ATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCAGTGCACCCGGCGGAATCTTGGAATTTTTATAGACAGCACCT
CAGTTTCTGACTCCAGCCGCACACCTCCTGCCTCTGCCAGCAGGGGTTGCCGCCAGACCAGAGCCAGGGCCAGGTCCCTGCGTCCATCCC
CCCCGGTAGGATGGACGTGAGCCATCCTTCTAGGGGACTTTTTTCAGTGTGCGACTCGTCTCTGTTAGGTGGTAGGAGCCAGTTTGTGTG
GCCTGTGCCACGCTCCACAGTGCGTGGCTGGGCTCTGTGTGTGGCCTGTGTCCCCTGTCCCTGCAGGACCCAGCAGGCATCGTGGCGTGA
CAGCTGTGTCCAAGCCACTGCCCGGGCATCCCATCACCCACCAGGGTGCACGGTCTCTCCTGCTGGGGGCTTTCTGTCGCATGTGTGTCT
CCTGTCGACTCTGCAGTTTGTTCTCAGAGCAGAATGTTTCCTGTTCTCAGTGCACAAAGACACTGGTTTTCAATCGGCGTCTAAAACCAC
GTTCCTGCCTTTCATTGCAACACGGTGTGTTCATTTGTTTAAAACAGTTTAATGAGTAAGTTTAGATGACTGGTCAATATCTTAAAAATG
TATATTAGTAAGAAGTTCTTCCTGGAATTTTTCTTTCGATTCTGGCAGAATAAACAGGTGTTTTTAGTTTTCCCACTGTCTGAGCCAAGC
AGGACCCTGTCCCAGAGCAAGAGATGTCCCCTTCCATCTCTGACCCTTGCCTGGGACAAGCTTTGATGGGGGGCCCCAGCTTCAAGGCTG
TGGTGGGAACAGCACCCCCAAATGCCAGCCTCTCCTTTCTTCCCATCCACCAGTATACTGCGGGGCCATTTCTGGTCTTTGTCCAACAGG
AAACCCATTTCTGGTGGGATATGCCTTCCAGTGCCACAGGGCCACTCACCCCATGCATCTCTGTCCTGCCCGTCAGTGCTGGGACGGACA
GCAAGGGCAAGCCCAGTGTCTGGCGGATAGGTGGGTGGGAACAGAGAGGGGAGAATGCCGTCCTAAGCTTCTGCTTGGGGATCCCCCACA
CGACCTGGGTACTGCCTGGGAAACCTGTCCTAAGTAAAACTATGGACCTCGCCTCGCCCACCGGCCTGCGAAGCCAGCATCTCCGTGAAG
GTGGATGGAAGCGCCTTTGTCCTCATTTTGAGCTGCAAGCTGGGTCAGCGGCTCTGAAGCCCTCGAGTGACTTTCTAACCCAAGACCCAG
CCCCTGGCAGGAGGAGGGTGGGTGCAGGGCTGGTGGGACAAAAAGAGGCCTCAGCAGGCCTGGAAGACCCTTCCAGTACATCCCACAGCG
TGTCGAGCAGCTGGGAGAACCTGTGTCAAGCTCGAGCCGTCATAGGTCCCCATGAGGTGTCTGAAGCCCCTTCTTGGTGATGGGAGGCAG
AGGTGCTGACGTTCTGGAGCATGGACGTGAGTCCTCAGCTGGCTCCGCGTGGGCCCTTGGAGGGTGCCAGGTGTGTGGTGACCTTCTGGA
TGCCTTTAACTTCATGGCTGCGTCATTCCTGATTTAGAACTTTAACCGGAGCTTCATCTAGTGATTGCAAAACTGGACCAATGGGAGGAC
GGCGGCGCAGCCCGCTCCCTCCGTGGAATGGAGCTCAGCTCTTCGGAGGCATCAAAGCACCTGTCGCCTCCGTGGTCCCCCTGCTGAGGG
AGTGCGGCCTCTGCAAGGTTCGGGGGTGGCTTCGTTTGCCTGGAGTGGCCGGCCCTGCTTGTGCCATGTGGATGTTTGTGAGCCTCGGTC
CTACAGCACTGTGTAGGCTGCATCTGTTTCGTGCTGGTCCTGTTGACTTGTATGATATCCACAAATAAATATTTTCATGGCGGTCGTGTT

>68228_68228_1_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000291565_length(amino acids)=494AA_BP=210
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIE
LDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTGYTRDK
SFLAMVVDIVQELKQQNPRLVYVCDPVLGDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSM
GPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQ

--------------------------------------------------------------
>68228_68228_2_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000327574_length(transcript)=2699nt_BP=736nt
ACGACACTTGTGCGGCAGCGGCGGCGGCCACCCGGCGCTCCTTCGCGACGGTTCGGCCGGGTGCCGCTGGCGGCCGTTGCCAGGGTAGGG
GTCGCTTTGCGGCATGGCGATGGCGGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAA
GCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGA
GCTGAACCCCAGCAATGCCATCTACTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCAC
GCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCT
GCGAGACTACGAGACGGTGGTCAAGGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAA
GGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTA
CAGCGGACCCAAGCTTGAAGACGGCAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCG
GAAATGTGCCTACCAGGTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGAGACAAGGTCGGTCTCTGT
CGCCCAGGCTGGCGTGAAGTGGCGCAACCAGCTCACTGCAGCCTTGACCTCCTGGGCTGAAGCAATCTTTCTGCCTCCACCTCCCGAGTG
GCTGGGACTATAGTTGTGCACCAGCACGCCCACCTCCTGCCCAGGGTTGTTACTGGGGTGGTCACGTGGGCAGCTTCTGCCTGGGATGGG
CCACAAAGCCAGACTCCCGGCAGGGACACGGGTGTTCCACACAAGCTGCGTTGTTGGTTCCCTGACGCCCTTCAGGCTGGGGGGTGGGAA
AGCCGATCCCCCAAGTGCCTGCAGAGCCCACCTGGCGCAGGCCTCGCCGCCTCGAGGCTGCTGCTCGCACTTCTGCCCCTTCCCCCGGCC
AGGCCCCCGTTCCTTGAGGCCGTACCACAAGGTGCGTTCATTTTTCCACACCGTGAGCTGGGCTTGGCAGAGCCTCCACCTTGTGGCCAG
TATTCCCAGTGGCCCCTTTGAGAGGATTTCCTGGAGCTCCCTGTCTGAGCTTCCCGGACTGAGGGCACTGGGAAGGAGCCTGCGGAGCTG
GAGGTCAGCGGGTGGACGGGTTGCGCTGTCCTGGCTTTCGGAGTGTAGAGCCAGAGGGGATGGGACAGGTGCCCTGCTGCTGGGCTTGGT
GGTCCCTGCTGCAGGGAAGGGGCAGCTGGTGTGAACACAAGGAGCTGCGGGGCTGGAGAAGGCCAGGGCCAGGAGCCTGCCGACGGACAC
CAGCGAGGGGCCAGGCCGGGCCAGGAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAGACTCCCTGGCCGGCTGGGATCTGA
CAGGAGTGCCAGGCTCCTTGGGCCGCCCGAGGAACCGCTTGTTTGCCTGTGCTTTTTCATCTGTAAATGGAATGAGTTGGACACAAGATC
CAAGCGCCCTCCCCTGTTGGAGAAGGTTCTTGTGGGCTCTGGGCCCATCCCACATCCCACAGTGGGCAGGAGGCCACCAAGAGGTGCAAG
ACCATGCCCTCTGTTTCGATAGGAAGCTGGGCCTCAGAGGGGCCTGGGGCCTGTGTCTGAGACCCGGCCAAGTGCTGGACGTCTCCCCTT
CCTCATGGCTGTTATGGCTGAATTACGTCCCCCCAAATTCTCATGTTGCAGCCTTAACCCCAGCACCTCAGTGTGGGACTGGGTTTGGAG
ATGGAGCCCCTACAGAGGTCAGCAGGTTAAAAGAGGCCATCAGGGCTCTGGGTGGGCCCTGATCCAAGCTGCTTGGTGTCCTTGTAAGAA
GAAGAGATGAGGACACAGACACACACAGAGGGACAGCCCCATGAGGAAACAGGGAGGCAATGCCGTCTGCAAGCCCAGGGCAGAGGCCTC
AGGAACCAGCCCTGGTGACACCTGGACCTTGGACCCCCGTGCCCAGGACAGTAGGAGAATTGGAGCCGCCTGGCTGCAGTCCTTCCCGAT
GGCACCCTGTATTAGTCCGTTCTCACACTGCTAATTGTTGGGAAAAGGGCTTGTGGAATGCCTGTATAAACTGGCCATGAAAATATGGGA
CAATAAGTTGTGGAAAGCCACAAGAGGCCTCTGAGGAGGAAAGCCTCCTAATTGCCATCATGTTCGCATGCTCAGGGCGAGACCTGCTGT
CTTATCTGTAAACACCGTGTTCAAGGAGAAAGACATTCCTTCGAAGCACTGGACTGTGGACAGACACACGAGCTCCTGGTTAAGCCCGCT
CCCACCAGCTCCTGTCCGATAAGTTAAAGATACGCTGTTTGAGCACAAAGGAGATTCATTGAAACCGCTATTGCTGTAGATTACGCCTGT

>68228_68228_2_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000327574_length(amino acids)=349AA_BP=1
MPTVGCGMGPEPTRTFSNRGGRLDLVSNSFHLQMKKHRQTSGSSGGPRSLALLSDPSRPGSLARPGPSLVSVGRLLARPGPSLVSVGRLL
ALAFSSPAAPCVHTSCPFPAAGTTKPSSRAPVPSPLALHSESQDSATRPPADLQLRRLLPSALSPGSSDRELQEILSKGPLGILATRWRL
CQAQLTVWKNERTLWYGLKERGPGRGKGQKCEQQPRGGEACARWALQALGGSAFPPPSLKGVREPTTQLVWNTRVPAGSLALWPIPGRSC

--------------------------------------------------------------
>68228_68228_3_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000398081_length(transcript)=2699nt_BP=736nt
ACGACACTTGTGCGGCAGCGGCGGCGGCCACCCGGCGCTCCTTCGCGACGGTTCGGCCGGGTGCCGCTGGCGGCCGTTGCCAGGGTAGGG
GTCGCTTTGCGGCATGGCGATGGCGGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAA
GCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGA
GCTGAACCCCAGCAATGCCATCTACTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCAC
GCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCT
GCGAGACTACGAGACGGTGGTCAAGGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAA
GGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTA
CAGCGGACCCAAGCTTGAAGACGGCAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCG
GAAATGTGCCTACCAGGTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGAGACAAGGTCGGTCTCTGT
CGCCCAGGCTGGCGTGAAGTGGCGCAACCAGCTCACTGCAGCCTTGACCTCCTGGGCTGAAGCAATCTTTCTGCCTCCACCTCCCGAGTG
GCTGGGACTATAGTTGTGCACCAGCACGCCCACCTCCTGCCCAGGGTTGTTACTGGGGTGGTCACGTGGGCAGCTTCTGCCTGGGATGGG
CCACAAAGCCAGACTCCCGGCAGGGACACGGGTGTTCCACACAAGCTGCGTTGTTGGTTCCCTGACGCCCTTCAGGCTGGGGGGTGGGAA
AGCCGATCCCCCAAGTGCCTGCAGAGCCCACCTGGCGCAGGCCTCGCCGCCTCGAGGCTGCTGCTCGCACTTCTGCCCCTTCCCCCGGCC
AGGCCCCCGTTCCTTGAGGCCGTACCACAAGGTGCGTTCATTTTTCCACACCGTGAGCTGGGCTTGGCAGAGCCTCCACCTTGTGGCCAG
TATTCCCAGTGGCCCCTTTGAGAGGATTTCCTGGAGCTCCCTGTCTGAGCTTCCCGGACTGAGGGCACTGGGAAGGAGCCTGCGGAGCTG
GAGGTCAGCGGGTGGACGGGTTGCGCTGTCCTGGCTTTCGGAGTGTAGAGCCAGAGGGGATGGGACAGGTGCCCTGCTGCTGGGCTTGGT
GGTCCCTGCTGCAGGGAAGGGGCAGCTGGTGTGAACACAAGGAGCTGCGGGGCTGGAGAAGGCCAGGGCCAGGAGCCTGCCGACGGACAC
CAGCGAGGGGCCAGGCCGGGCCAGGAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAGACTCCCTGGCCGGCTGGGATCTGA
CAGGAGTGCCAGGCTCCTTGGGCCGCCCGAGGAACCGCTTGTTTGCCTGTGCTTTTTCATCTGTAAATGGAATGAGTTGGACACAAGATC
CAAGCGCCCTCCCCTGTTGGAGAAGGTTCTTGTGGGCTCTGGGCCCATCCCACATCCCACAGTGGGCAGGAGGCCACCAAGAGGTGCAAG
ACCATGCCCTCTGTTTCGATAGGAAGCTGGGCCTCAGAGGGGCCTGGGGCCTGTGTCTGAGACCCGGCCAAGTGCTGGACGTCTCCCCTT
CCTCATGGCTGTTATGGCTGAATTACGTCCCCCCAAATTCTCATGTTGCAGCCTTAACCCCAGCACCTCAGTGTGGGACTGGGTTTGGAG
ATGGAGCCCCTACAGAGGTCAGCAGGTTAAAAGAGGCCATCAGGGCTCTGGGTGGGCCCTGATCCAAGCTGCTTGGTGTCCTTGTAAGAA
GAAGAGATGAGGACACAGACACACACAGAGGGACAGCCCCATGAGGAAACAGGGAGGCAATGCCGTCTGCAAGCCCAGGGCAGAGGCCTC
AGGAACCAGCCCTGGTGACACCTGGACCTTGGACCCCCGTGCCCAGGACAGTAGGAGAATTGGAGCCGCCTGGCTGCAGTCCTTCCCGAT
GGCACCCTGTATTAGTCCGTTCTCACACTGCTAATTGTTGGGAAAAGGGCTTGTGGAATGCCTGTATAAACTGGCCATGAAAATATGGGA
CAATAAGTTGTGGAAAGCCACAAGAGGCCTCTGAGGAGGAAAGCCTCCTAATTGCCATCATGTTCGCATGCTCAGGGCGAGACCTGCTGT
CTTATCTGTAAACACCGTGTTCAAGGAGAAAGACATTCCTTCGAAGCACTGGACTGTGGACAGACACACGAGCTCCTGGTTAAGCCCGCT
CCCACCAGCTCCTGTCCGATAAGTTAAAGATACGCTGTTTGAGCACAAAGGAGATTCATTGAAACCGCTATTGCTGTAGATTACGCCTGT

>68228_68228_3_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000398081_length(amino acids)=349AA_BP=1
MPTVGCGMGPEPTRTFSNRGGRLDLVSNSFHLQMKKHRQTSGSSGGPRSLALLSDPSRPGSLARPGPSLVSVGRLLARPGPSLVSVGRLL
ALAFSSPAAPCVHTSCPFPAAGTTKPSSRAPVPSPLALHSESQDSATRPPADLQLRRLLPSALSPGSSDRELQEILSKGPLGILATRWRL
CQAQLTVWKNERTLWYGLKERGPGRGKGQKCEQQPRGGEACARWALQALGGSAFPPPSLKGVREPTTQLVWNTRVPAGSLALWPIPGRSC

--------------------------------------------------------------
>68228_68228_4_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000468090_length(transcript)=7748nt_BP=736nt
ACGACACTTGTGCGGCAGCGGCGGCGGCCACCCGGCGCTCCTTCGCGACGGTTCGGCCGGGTGCCGCTGGCGGCCGTTGCCAGGGTAGGG
GTCGCTTTGCGGCATGGCGATGGCGGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAA
GCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGA
GCTGAACCCCAGCAATGCCATCTACTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCAC
GCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCT
GCGAGACTACGAGACGGTGGTCAAGGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAA
GGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTA
CAGCGGACCCAAGCTTGAAGACGGCAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCG
GAAATGTGCCTACCAGGTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGG
CCAAGTGCTGAATTCAGATGAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGTGTG
TGATCCAGTCTTGGGTGACAAGTGGGACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCC
GCTTGCAGACATTATCACGCCCAACCAGTTTGAGGCCGAGTTACTGAGTGGCCGGAAGATCCACAGCCAGGAGGAAGCCTTGCGGGTGAT
GGACATGCTGCACTCTATGGGCCCCGACACCGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATTGTGCT
GGGGAGTCAGAGGAGGAGGAATCCCGCTGGCTCCGTGGTGATGGAACGCATCCGGATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGG
CACTGGGGACCTGTTTGCTGCCATGCTCCTGGCGTGGACACACAAGCACCCCAATAACCTCAAGGTGGCCTGTGAGAAGACCGTGTCTAC
CTTGCACCACGTTCTGCAGAGGACCATCCAGTGTGCAAAAGCCCAGGCCGGGGAAGGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCG
GATGGTGCAGAGCAAAAGGGACATCGAGGACCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGAGGGCCCCGCCGCTTGCCCGTGACACG
CAGCGCGTTGGTGTCTCCGTGTTTGTCCCTGTGAAAACATGTAACGTCTGCCTTAGAGCCATGACCGAAACTTGATATTTTTTTCTTTCA
TGAGTGTCCGGCATCTGCTGGTCTTCATTGTGAAACGTGCCAGTCGTGCTTTGTGAAAAATAACAAAGTGGTCACAGAAATTTGTGATCT
GAAAACCCGGCTCCCTTCCCCACAAGGCTCCTGGGCCTCCGGGAAGACGGGCCCCTGTTTGCCATCTCGGGGGTGTTCCCTGTGGGAGGG
TGAGTGGGTGAGGCCGAGCCTGCTGCGTGTGGAGCCTCGAGTGGGCCCTGGCTGCCACTACCGTACAGAGGCCGTGTCGCGCTGGGCTGG
GCCTGGGTGGCCTCTGTCTTTGCATCTCTGAGAAGGAGTCGGGTGGTAACGGTTGGGGTCAGGAAGAATTCTGCCAAGTATCTTTACTGT
CATTCTGACCATAGCCTCTTTGTTCCCGCATTCGAACTTTTGGTTCTTACTTTGCTGCTCGTTTAGTCCCTGGGGATTTCAGATCTTAGG
CTGTTGTTTCACCGTATGGGAGGGTTGATGTGAGCTTGCTTGGAGACACACGGTGCAGCATCAGGGACCTTCCCAGGCCCCAGCAAATTC
AAGTCGGTCTGCAGACCTCTCAGCTACCCGCGGGACCTCTTGTAACCCATCGGCATCTTCCAGGAATCCGCCGAGTGACTTGAGGAAGAT
GCTAACGCAGTAAGGTCTGTGCTGGGCCAAGAGCAGCTTTGAAGCTCCAGAGAACCACCCCGTCAGGTTCCTTGTGGAAGCTCCCCTCAT
CCGTGGTGCAGCAGGCTGAGCACTGCGCGTTTGCCACGTGCTGCCCGTGACAGCACATTGAGCCACAGCATTTGTAGACAGGACAGAGGG
GTGCCTGCCCCCTGCCCCTGCTGGCACATTTAACCCTTGTCCCCTGACCTCAGTTCTGTGCCCCACCAAATGCCCAGGGGCAAGAGGCCA
CCCTGGAAGCTGCCAATCTTCCAAGGTGGGTGTGGGGCACGGTGGGGGCGGGCAGCTCCCAGGCCCTTGGGCAGGCTGGGGTGACGGCAG
AGGCCACAGCACCAGCTCTGACAAGTCCTATCATCCTCTGCTCAGCAGTGACCTCCCTGGCCCCACTTTGCCCAGAGTTTGGGGTCCCCC
CAGGTATAGCTATAGGCGGCAGTGCCTGTCCCTGGCCTGCCTTGATTTCAGCCACACCCCTGCAGCCCTGCATCCCAGCTCTGGGGTGTG
CAGAGGTTTGTGTCTCCAGGGAACCCACGGCTGGAGAGAAATAGGGAGATGCAGGAAGTGGGGGCCCATGGGGCCCCCAAGAAGCGGACT
CTCCAAGGGGTACCCCCACCCCGCTACCTTCCCCACGGACGGGCCCCTCCTGGAGCCCATACCCTCCTGTGAGGCCATTCCAGTGTCTTC
TAGAAAGACTCGCTTGCCAGGAGTGCGTTCTTTGTTGAAAAATGCCCTGAAGCGAAAAGATGCAGGTTTATATGGAACCCCCACCCCCTC
CCCCACTCTCCCACTCTGTTCGTTCTGAATGTCTTCACGAGCGTGCATCAGGGCGCCTGGCTCCCCCACCTCAGCCAGTGAGTCAGACAC
GGGTTTCGCAGCCATGTTTCCTGGCTCCGAGGACACGGGTGGCAGGCCCGTTGCAGCCCAGAGCCACTGGTCCCTACAGGGCGCCGCCAC
ACCAGCAGGAAGGAGGATGGCTGTGTCCGGAGCCTGGCGGGGAGGCGGCCTCCCCAGTATGTGAGTGCAGGGATCTGCCAGAACCACCTG
GCCCTCTGTAGGGCGTTTAACTGGAAATACCCTCACTGCCAAGTGGAGACTGGGGCGTGTGCCACATTGCCAGCCACCAGGAAAGCTTTT
CTTTTTCTTTTTTTTTTTTTTTTAAACACCAAGAGCACGTATAGCATGGGGGAAAGAACCTAAATGTCTCTCTGTCCTGTGAGCTGGTGA
AAAACCCAGCATGAGAACGCAGTGTCAGGTGTGGGACTCCTTCTGCCCCTGCAGTGGGTGTTACGGGCGGTGTGCCCTGGCGAGCAAGCT
TTGATTCTTGGTTCTTTGAGCTCGTTTCAGAGGCTGAGTCCCCACATCAGCTTTAGTTCTTGGACTTCCCTGTATTAAGCAAGAATTAGG
AGAATGGCTGTCCCTGCAGGCGCCTCCCGTAAATCCTGAGCTCTCTGGCGCAATCTGAAACTTCTCTTCTGTTTTCTTTGGCTGTATCAG
CCGAACCAGGAGAGGCCTGGGCTGCGACTAAGGAGAAAGAAATCGGGGGTTTCTGAGAGCAGATGGTGCCTTTGTGGGTGCAGGGCTTTT
GTGGAAATTGTCAGCCTCTACGGGCAGAGTCCGGCATCCCCTCCCCAGACTGCCTGCTGTCAAACCACGGAGCAGCTGGAGCCTGCCCTG
TCCACGGCCCGTTTCCACCCGGGCATGTTCGTCTCTCCTGACTTCGGCAGAGGCCCCTGGTGGCCTTCAGTTTCAGTTTCTCATCCAGGA
AGGTAACCTTGGGCATTGGCAGTGGGTTTCCCTATGGCTTGGATCCAGATTAGAATTGATCTTTGTTTTCACTTTCCATAGTTAATAACA
TGCAAAATAATGAGAAGAATTTATTTTAAGGTGACAGCTATACTGGTCCAACATCGCCTGCTTATTGTCAGGGTACAGAAGTTTAATACT
TTCTTAATCCAGTTTTTCAAACTTCTCCCTGTAGACCGTAAGGATGAATTCCACAATAGGATCCTTTTTAAAATCGATTTTAAATTGTTG
CCTAGTCCTGCCAAGGTTATTATGTGCATCTGTTATTTTTCCAATACATGTAAACAGTTGCAGCATGATGCTTTGTTTAATGTCCTGTTC
TTAAGCTCGTTAGAGCCAGTTTTGAAACGTTTGGTCTTACCGTGAACGGAGGCTGGCTTGGCTTAGCCACGCTGATGAGTAAGTGAGGGA
TGTCTCCATCTTGAGATCACCAGGCAAGAGAGTTGCCTGCACCAGGTAAGAGGCCAAAGCCCCTGGGGTAACAGTCCCCACCGCTACCCG
AGGTAAAACAATAAAAGCTATGTGGTTGAGCTCAGGCCTCTCGTGCCTGGTGTCAGAGAAGGCAGAGCCCACAGTAGGTGCACGGTGCAA
GGCCCTGGGAGGGCACTGGCCAGGGAAGGTGGTATAGATGGCCCTCAGATTGCGGGGCCCCGAGCAGCTCCCCACTCTGCCCGTCCACCT
TCCCTGGCTCCAGCCTCATTCTCTCTTTAGTTTAACTATGCAAAGAGAGGAGGTTGAGAGTGTTCTGGCAGCTGGAGCTCTTTTCCTTGT
CCTTCCTGCCCTCCGATGGGGCCACCTGTGTCGGGGCAGCAGTGTCCATGTTTATGGAGATCAGAGGTGTCCCCACTGTGTGGCTGGACT
GTACTCTGCTGCCCGGGTAGCCAGGAGTCTCTCCCTCTCTCCCCTGCCGCCTGCCTGGTCTCATGGGCCTCCTTCACACACCCCTCCCTG
TGGATCGCCTGCCTGGGCCCAGAGCAGGGGAACTGGAGTTTGTGAGTGAGCAGAGCAGGTTATGTGCAGACAGGGAAACGAGAACTTTGG
ACCTGGCTTTCTGAGTCCAGGTGAGAGCTGTGTGGCCCCCCGATGCCACTCTGCCCGCCGGAGGGATGTGCCTGCTGAGCCTTTTCCTTC
CACGCCGCCTCTCACTGCCAGGCCAGCGGCTTCCGCTGAGACTCGCTGGAGAGGCGGCTCCCGTGTCCGTCCACCGAGCACTCAGATGGA
TGCTGATCACCAGGGCCGAGGGGGCTCCCAGAAGGACCCCAGGCCCTGGGGAGGGTGGCTGTGGGAGGCCAAGTCCACTGCCCGGAAGTC
TTGTCAGCCCTAAGCCAGGGAAGCCTGGAGCGTGGCCTGGCGGGTCTGGGTGGACACCGTCCCCACTCCGGACTCCCAGCACAGGGGAGG
ATACCTGAGCCTGTATGGCCCTGTAGCCCTGGGCAGAGCTGGGCCTGTCGTGTGTTCCTGCCTGGCAGGTGCAGGTGCTGGCCATCTGCA
GGTGGAAGGAGGTGGGAATCTTGGATTTTTTGTTTTTTTTTGTTTTTTTTTTTTTGAGGTGAAGTCTCGCTCTGACACCCAGGCTGGCGT
GCAGTGGTGTGATCTCGGCTCACTGCAAACTCCGCTTCCTGGGTTCAAGTGGTTCTCCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAG
GCATGCGCCACCACGCTCAGCTGATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTGACCT
CAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCAGTGCACCCGGCGGAATCTTGGAATTTTTATAGACA
GCACCTCAGTTTCTGACTCCAGCCGCACACCTCCTGCCTCTGCCAGCAGGGGTTGCCGCCAGACCAGAGCCAGGGCCAGGTCCCTGCGTC
CATCCCCCCCGGTAGGATGGACGTGAGCCATCCTTCTAGGGGACTTTTTTCAGTGTGCGACTCGTCTCTGTTAGGTGGTAGGAGCCAGTT
TGTGTGGCCTGTGCCACGCTCCACAGTGCGTGGCTGGGCTCTGTGTGTGGCCTGTGTCCCCTGTCCCTGCAGGACCCAGCAGGCATCGTG
GCGTGACAGCTGTGTCCAAGCCACTGCCCGGGCATCCCATCACCCACCAGGGTGCACGGTCTCTCCTGCTGGGGGCTTTCTGTCGCATGT
GTGTCTCCTGTCGACTCTGCAGTTTGTTCTCAGAGCAGAATGTTTCCTGTTCTCAGTGCACAAAGACACTGGTTTTCAATCGGCGTCTAA
AACCACGTTCCTGCCTTTCATTGCAACACGGTGTGTTCATTTGTTTAAAACAGTTTAATGAGTAAGTTTAGATGACTGGTCAATATCTTA
AAAATGTATATTAGTAAGAAGTTCTTCCTGGAATTTTTCTTTCGATTCTGGCAGAATAAACAGGTGTTTTTAGTTTTCCCACTGTCTGAG
CCAAGCAGGACCCTGTCCCAGAGCAAGAGATGTCCCCTTCCATCTCTGACCCTTGCCTGGGACAAGCTTTGATGGGGGGCCCCAGCTTCA
AGGCTGTGGTGGGAACAGCACCCCCAAATGCCAGCCTCTCCTTTCTTCCCATCCACCAGTATACTGCGGGGCCATTTCTGGTCTTTGTCC
AACAGGAAACCCATTTCTGGTGGGATATGCCTTCCAGTGCCACAGGGCCACTCACCCCATGCATCTCTGTCCTGCCCGTCAGTGCTGGGA
CGGACAGCAAGGGCAAGCCCAGTGTCTGGCGGATAGGTGGGTGGGAACAGAGAGGGGAGAATGCCGTCCTAAGCTTCTGCTTGGGGATCC
CCCACACGACCTGGGTACTGCCTGGGAAACCTGTCCTAAGTAAAACTATGGACCTCGCCTCGCCCACCGGCCTGCGAAGCCAGCATCTCC
GTGAAGGTGGATGGAAGCGCCTTTGTCCTCATTTTGAGCTGCAAGCTGGGTCAGCGGCTCTGAAGCCCTCGAGTGACTTTCTAACCCAAG
ACCCAGCCCCTGGCAGGAGGAGGGTGGGTGCAGGGCTGGTGGGACAAAAAGAGGCCTCAGCAGGCCTGGAAGACCCTTCCAGTACATCCC
ACAGCGTGTCGAGCAGCTGGGAGAACCTGTGTCAAGCTCGAGCCGTCATAGGTCCCCATGAGGTGTCTGAAGCCCCTTCTTGGTGATGGG
AGGCAGAGGTGCTGACGTTCTGGAGCATGGACGTGAGTCCTCAGCTGGCTCCGCGTGGGCCCTTGGAGGGTGCCAGGTGTGTGGTGACCT
TCTGGATGCCTTTAACTTCATGGCTGCGTCATTCCTGATTTAGAACTTTAACCGGAGCTTCATCTAGTGATTGCAAAACTGGACCAATGG
GAGGACGGCGGCGCAGCCCGCTCCCTCCGTGGAATGGAGCTCAGCTCTTCGGAGGCATCAAAGCACCTGTCGCCTCCGTGGTCCCCCTGC
TGAGGGAGTGCGGCCTCTGCAAGGTTCGGGGGTGGCTTCGTTTGCCTGGAGTGGCCGGCCCTGCTTGTGCCATGTGGATGTTTGTGAGCC
TCGGTCCTACAGCACTGTGTAGGCTGCATCTGTTTCGTGCTGGTCCTGTTGACTTGTATGATATCCACAAATAAATATTTTCATGGCGGT

>68228_68228_4_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000012443_PDXK_chr21_45153949_ENST00000468090_length(amino acids)=466AA_BP=210
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIE
LDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTVCDPVL
GDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQR
RRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQS

--------------------------------------------------------------
>68228_68228_5_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000291565_length(transcript)=7718nt_BP=622nt
GGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAAGCGGGCAGAGGAGCTCAAGACTCA
GGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGCAATGCCATCTA
CTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCACGCGGGCCATTGAGCTGGACAAGAA
GTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAGACGGTGGTCAA
GGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAAGGCCTTTGAGCGGGCCATCGCGGG
CGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAGCTTGAAGACGG
CAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCGGAAATGTGCCTACCAGGTTTTGGG
ATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGATGAGCT
CCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGGTTATACGAGGGACAAGTCGTTCCTGGC
CATGGTGGTGGACATTGTGCAGGAGCTGAAGCAGCAGAACCCCAGGCTGGTGTACGTGTGTGATCCAGTCTTGGGTGACAAGTGGGACGG
CGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCCGCTTGCAGACATTATCACGCCCAACCAGTT
TGAGGCCGAGTTACTGAGTGGCCGGAAGATCCACAGCCAGGAGGAAGCCTTGCGGGTGATGGACATGCTGCACTCTATGGGCCCCGACAC
CGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATTGTGCTGGGGAGTCAGAGGAGGAGGAATCCCGCTGG
CTCCGTGGTGATGGAACGCATCCGGATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGGCACTGGGGACCTGTTTGCTGCCATGCTCCT
GGCGTGGACACACAAGCACCCCAATAACCTCAAGGTGGCCTGTGAGAAGACCGTGTCTACCTTGCACCACGTTCTGCAGAGGACCATCCA
GTGTGCAAAAGCCCAGGCCGGGGAAGGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCGGATGGTGCAGAGCAAAAGGGACATCGAGGA
CCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGAGGGCCCCGCCGCTTGCCCGTGACACGCAGCGCGTTGGTGTCTCCGTGTTTGTCCCT
GTGAAAACATGTAACGTCTGCCTTAGAGCCATGACCGAAACTTGATATTTTTTTCTTTCATGAGTGTCCGGCATCTGCTGGTCTTCATTG
TGAAACGTGCCAGTCGTGCTTTGTGAAAAATAACAAAGTGGTCACAGAAATTTGTGATCTGAAAACCCGGCTCCCTTCCCCACAAGGCTC
CTGGGCCTCCGGGAAGACGGGCCCCTGTTTGCCATCTCGGGGGTGTTCCCTGTGGGAGGGTGAGTGGGTGAGGCCGAGCCTGCTGCGTGT
GGAGCCTCGAGTGGGCCCTGGCTGCCACTACCGTACAGAGGCCGTGTCGCGCTGGGCTGGGCCTGGGTGGCCTCTGTCTTTGCATCTCTG
AGAAGGAGTCGGGTGGTAACGGTTGGGGTCAGGAAGAATTCTGCCAAGTATCTTTACTGTCATTCTGACCATAGCCTCTTTGTTCCCGCA
TTCGAACTTTTGGTTCTTACTTTGCTGCTCGTTTAGTCCCTGGGGATTTCAGATCTTAGGCTGTTGTTTCACCGTATGGGAGGGTTGATG
TGAGCTTGCTTGGAGACACACGGTGCAGCATCAGGGACCTTCCCAGGCCCCAGCAAATTCAAGTCGGTCTGCAGACCTCTCAGCTACCCG
CGGGACCTCTTGTAACCCATCGGCATCTTCCAGGAATCCGCCGAGTGACTTGAGGAAGATGCTAACGCAGTAAGGTCTGTGCTGGGCCAA
GAGCAGCTTTGAAGCTCCAGAGAACCACCCCGTCAGGTTCCTTGTGGAAGCTCCCCTCATCCGTGGTGCAGCAGGCTGAGCACTGCGCGT
TTGCCACGTGCTGCCCGTGACAGCACATTGAGCCACAGCATTTGTAGACAGGACAGAGGGGTGCCTGCCCCCTGCCCCTGCTGGCACATT
TAACCCTTGTCCCCTGACCTCAGTTCTGTGCCCCACCAAATGCCCAGGGGCAAGAGGCCACCCTGGAAGCTGCCAATCTTCCAAGGTGGG
TGTGGGGCACGGTGGGGGCGGGCAGCTCCCAGGCCCTTGGGCAGGCTGGGGTGACGGCAGAGGCCACAGCACCAGCTCTGACAAGTCCTA
TCATCCTCTGCTCAGCAGTGACCTCCCTGGCCCCACTTTGCCCAGAGTTTGGGGTCCCCCCAGGTATAGCTATAGGCGGCAGTGCCTGTC
CCTGGCCTGCCTTGATTTCAGCCACACCCCTGCAGCCCTGCATCCCAGCTCTGGGGTGTGCAGAGGTTTGTGTCTCCAGGGAACCCACGG
CTGGAGAGAAATAGGGAGATGCAGGAAGTGGGGGCCCATGGGGCCCCCAAGAAGCGGACTCTCCAAGGGGTACCCCCACCCCGCTACCTT
CCCCACGGACGGGCCCCTCCTGGAGCCCATACCCTCCTGTGAGGCCATTCCAGTGTCTTCTAGAAAGACTCGCTTGCCAGGAGTGCGTTC
TTTGTTGAAAAATGCCCTGAAGCGAAAAGATGCAGGTTTATATGGAACCCCCACCCCCTCCCCCACTCTCCCACTCTGTTCGTTCTGAAT
GTCTTCACGAGCGTGCATCAGGGCGCCTGGCTCCCCCACCTCAGCCAGTGAGTCAGACACGGGTTTCGCAGCCATGTTTCCTGGCTCCGA
GGACACGGGTGGCAGGCCCGTTGCAGCCCAGAGCCACTGGTCCCTACAGGGCGCCGCCACACCAGCAGGAAGGAGGATGGCTGTGTCCGG
AGCCTGGCGGGGAGGCGGCCTCCCCAGTATGTGAGTGCAGGGATCTGCCAGAACCACCTGGCCCTCTGTAGGGCGTTTAACTGGAAATAC
CCTCACTGCCAAGTGGAGACTGGGGCGTGTGCCACATTGCCAGCCACCAGGAAAGCTTTTCTTTTTCTTTTTTTTTTTTTTTTAAACACC
AAGAGCACGTATAGCATGGGGGAAAGAACCTAAATGTCTCTCTGTCCTGTGAGCTGGTGAAAAACCCAGCATGAGAACGCAGTGTCAGGT
GTGGGACTCCTTCTGCCCCTGCAGTGGGTGTTACGGGCGGTGTGCCCTGGCGAGCAAGCTTTGATTCTTGGTTCTTTGAGCTCGTTTCAG
AGGCTGAGTCCCCACATCAGCTTTAGTTCTTGGACTTCCCTGTATTAAGCAAGAATTAGGAGAATGGCTGTCCCTGCAGGCGCCTCCCGT
AAATCCTGAGCTCTCTGGCGCAATCTGAAACTTCTCTTCTGTTTTCTTTGGCTGTATCAGCCGAACCAGGAGAGGCCTGGGCTGCGACTA
AGGAGAAAGAAATCGGGGGTTTCTGAGAGCAGATGGTGCCTTTGTGGGTGCAGGGCTTTTGTGGAAATTGTCAGCCTCTACGGGCAGAGT
CCGGCATCCCCTCCCCAGACTGCCTGCTGTCAAACCACGGAGCAGCTGGAGCCTGCCCTGTCCACGGCCCGTTTCCACCCGGGCATGTTC
GTCTCTCCTGACTTCGGCAGAGGCCCCTGGTGGCCTTCAGTTTCAGTTTCTCATCCAGGAAGGTAACCTTGGGCATTGGCAGTGGGTTTC
CCTATGGCTTGGATCCAGATTAGAATTGATCTTTGTTTTCACTTTCCATAGTTAATAACATGCAAAATAATGAGAAGAATTTATTTTAAG
GTGACAGCTATACTGGTCCAACATCGCCTGCTTATTGTCAGGGTACAGAAGTTTAATACTTTCTTAATCCAGTTTTTCAAACTTCTCCCT
GTAGACCGTAAGGATGAATTCCACAATAGGATCCTTTTTAAAATCGATTTTAAATTGTTGCCTAGTCCTGCCAAGGTTATTATGTGCATC
TGTTATTTTTCCAATACATGTAAACAGTTGCAGCATGATGCTTTGTTTAATGTCCTGTTCTTAAGCTCGTTAGAGCCAGTTTTGAAACGT
TTGGTCTTACCGTGAACGGAGGCTGGCTTGGCTTAGCCACGCTGATGAGTAAGTGAGGGATGTCTCCATCTTGAGATCACCAGGCAAGAG
AGTTGCCTGCACCAGGTAAGAGGCCAAAGCCCCTGGGGTAACAGTCCCCACCGCTACCCGAGGTAAAACAATAAAAGCTATGTGGTTGAG
CTCAGGCCTCTCGTGCCTGGTGTCAGAGAAGGCAGAGCCCACAGTAGGTGCACGGTGCAAGGCCCTGGGAGGGCACTGGCCAGGGAAGGT
GGTATAGATGGCCCTCAGATTGCGGGGCCCCGAGCAGCTCCCCACTCTGCCCGTCCACCTTCCCTGGCTCCAGCCTCATTCTCTCTTTAG
TTTAACTATGCAAAGAGAGGAGGTTGAGAGTGTTCTGGCAGCTGGAGCTCTTTTCCTTGTCCTTCCTGCCCTCCGATGGGGCCACCTGTG
TCGGGGCAGCAGTGTCCATGTTTATGGAGATCAGAGGTGTCCCCACTGTGTGGCTGGACTGTACTCTGCTGCCCGGGTAGCCAGGAGTCT
CTCCCTCTCTCCCCTGCCGCCTGCCTGGTCTCATGGGCCTCCTTCACACACCCCTCCCTGTGGATCGCCTGCCTGGGCCCAGAGCAGGGG
AACTGGAGTTTGTGAGTGAGCAGAGCAGGTTATGTGCAGACAGGGAAACGAGAACTTTGGACCTGGCTTTCTGAGTCCAGGTGAGAGCTG
TGTGGCCCCCCGATGCCACTCTGCCCGCCGGAGGGATGTGCCTGCTGAGCCTTTTCCTTCCACGCCGCCTCTCACTGCCAGGCCAGCGGC
TTCCGCTGAGACTCGCTGGAGAGGCGGCTCCCGTGTCCGTCCACCGAGCACTCAGATGGATGCTGATCACCAGGGCCGAGGGGGCTCCCA
GAAGGACCCCAGGCCCTGGGGAGGGTGGCTGTGGGAGGCCAAGTCCACTGCCCGGAAGTCTTGTCAGCCCTAAGCCAGGGAAGCCTGGAG
CGTGGCCTGGCGGGTCTGGGTGGACACCGTCCCCACTCCGGACTCCCAGCACAGGGGAGGATACCTGAGCCTGTATGGCCCTGTAGCCCT
GGGCAGAGCTGGGCCTGTCGTGTGTTCCTGCCTGGCAGGTGCAGGTGCTGGCCATCTGCAGGTGGAAGGAGGTGGGAATCTTGGATTTTT
TGTTTTTTTTTGTTTTTTTTTTTTTGAGGTGAAGTCTCGCTCTGACACCCAGGCTGGCGTGCAGTGGTGTGATCTCGGCTCACTGCAAAC
TCCGCTTCCTGGGTTCAAGTGGTTCTCCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACGCTCAGCTGATTTTTG
TATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGA
GTGCTGGGATTACAGGCATGAGCCAGTGCACCCGGCGGAATCTTGGAATTTTTATAGACAGCACCTCAGTTTCTGACTCCAGCCGCACAC
CTCCTGCCTCTGCCAGCAGGGGTTGCCGCCAGACCAGAGCCAGGGCCAGGTCCCTGCGTCCATCCCCCCCGGTAGGATGGACGTGAGCCA
TCCTTCTAGGGGACTTTTTTCAGTGTGCGACTCGTCTCTGTTAGGTGGTAGGAGCCAGTTTGTGTGGCCTGTGCCACGCTCCACAGTGCG
TGGCTGGGCTCTGTGTGTGGCCTGTGTCCCCTGTCCCTGCAGGACCCAGCAGGCATCGTGGCGTGACAGCTGTGTCCAAGCCACTGCCCG
GGCATCCCATCACCCACCAGGGTGCACGGTCTCTCCTGCTGGGGGCTTTCTGTCGCATGTGTGTCTCCTGTCGACTCTGCAGTTTGTTCT
CAGAGCAGAATGTTTCCTGTTCTCAGTGCACAAAGACACTGGTTTTCAATCGGCGTCTAAAACCACGTTCCTGCCTTTCATTGCAACACG
GTGTGTTCATTTGTTTAAAACAGTTTAATGAGTAAGTTTAGATGACTGGTCAATATCTTAAAAATGTATATTAGTAAGAAGTTCTTCCTG
GAATTTTTCTTTCGATTCTGGCAGAATAAACAGGTGTTTTTAGTTTTCCCACTGTCTGAGCCAAGCAGGACCCTGTCCCAGAGCAAGAGA
TGTCCCCTTCCATCTCTGACCCTTGCCTGGGACAAGCTTTGATGGGGGGCCCCAGCTTCAAGGCTGTGGTGGGAACAGCACCCCCAAATG
CCAGCCTCTCCTTTCTTCCCATCCACCAGTATACTGCGGGGCCATTTCTGGTCTTTGTCCAACAGGAAACCCATTTCTGGTGGGATATGC
CTTCCAGTGCCACAGGGCCACTCACCCCATGCATCTCTGTCCTGCCCGTCAGTGCTGGGACGGACAGCAAGGGCAAGCCCAGTGTCTGGC
GGATAGGTGGGTGGGAACAGAGAGGGGAGAATGCCGTCCTAAGCTTCTGCTTGGGGATCCCCCACACGACCTGGGTACTGCCTGGGAAAC
CTGTCCTAAGTAAAACTATGGACCTCGCCTCGCCCACCGGCCTGCGAAGCCAGCATCTCCGTGAAGGTGGATGGAAGCGCCTTTGTCCTC
ATTTTGAGCTGCAAGCTGGGTCAGCGGCTCTGAAGCCCTCGAGTGACTTTCTAACCCAAGACCCAGCCCCTGGCAGGAGGAGGGTGGGTG
CAGGGCTGGTGGGACAAAAAGAGGCCTCAGCAGGCCTGGAAGACCCTTCCAGTACATCCCACAGCGTGTCGAGCAGCTGGGAGAACCTGT
GTCAAGCTCGAGCCGTCATAGGTCCCCATGAGGTGTCTGAAGCCCCTTCTTGGTGATGGGAGGCAGAGGTGCTGACGTTCTGGAGCATGG
ACGTGAGTCCTCAGCTGGCTCCGCGTGGGCCCTTGGAGGGTGCCAGGTGTGTGGTGACCTTCTGGATGCCTTTAACTTCATGGCTGCGTC
ATTCCTGATTTAGAACTTTAACCGGAGCTTCATCTAGTGATTGCAAAACTGGACCAATGGGAGGACGGCGGCGCAGCCCGCTCCCTCCGT
GGAATGGAGCTCAGCTCTTCGGAGGCATCAAAGCACCTGTCGCCTCCGTGGTCCCCCTGCTGAGGGAGTGCGGCCTCTGCAAGGTTCGGG
GGTGGCTTCGTTTGCCTGGAGTGGCCGGCCCTGCTTGTGCCATGTGGATGTTTGTGAGCCTCGGTCCTACAGCACTGTGTAGGCTGCATC

>68228_68228_5_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000291565_length(amino acids)=470AA_BP=186
MKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRA
ALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKL
HRKCAYQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVC
DPVLGDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVL
GSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELR

--------------------------------------------------------------
>68228_68228_6_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000327574_length(transcript)=2585nt_BP=622nt
GGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAAGCGGGCAGAGGAGCTCAAGACTCA
GGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGCAATGCCATCTA
CTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCACGCGGGCCATTGAGCTGGACAAGAA
GTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAGACGGTGGTCAA
GGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAAGGCCTTTGAGCGGGCCATCGCGGG
CGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAGCTTGAAGACGG
CAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCGGAAATGTGCCTACCAGGTTTTGGG
ATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGAGACAAGGTCGGTCTCTGTCGCCCAGGCTGGCGTGAAGTGGCG
CAACCAGCTCACTGCAGCCTTGACCTCCTGGGCTGAAGCAATCTTTCTGCCTCCACCTCCCGAGTGGCTGGGACTATAGTTGTGCACCAG
CACGCCCACCTCCTGCCCAGGGTTGTTACTGGGGTGGTCACGTGGGCAGCTTCTGCCTGGGATGGGCCACAAAGCCAGACTCCCGGCAGG
GACACGGGTGTTCCACACAAGCTGCGTTGTTGGTTCCCTGACGCCCTTCAGGCTGGGGGGTGGGAAAGCCGATCCCCCAAGTGCCTGCAG
AGCCCACCTGGCGCAGGCCTCGCCGCCTCGAGGCTGCTGCTCGCACTTCTGCCCCTTCCCCCGGCCAGGCCCCCGTTCCTTGAGGCCGTA
CCACAAGGTGCGTTCATTTTTCCACACCGTGAGCTGGGCTTGGCAGAGCCTCCACCTTGTGGCCAGTATTCCCAGTGGCCCCTTTGAGAG
GATTTCCTGGAGCTCCCTGTCTGAGCTTCCCGGACTGAGGGCACTGGGAAGGAGCCTGCGGAGCTGGAGGTCAGCGGGTGGACGGGTTGC
GCTGTCCTGGCTTTCGGAGTGTAGAGCCAGAGGGGATGGGACAGGTGCCCTGCTGCTGGGCTTGGTGGTCCCTGCTGCAGGGAAGGGGCA
GCTGGTGTGAACACAAGGAGCTGCGGGGCTGGAGAAGGCCAGGGCCAGGAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAG
GAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAGACTCCCTGGCCGGCTGGGATCTGACAGGAGTGCCAGGCTCCTTGGGCC
GCCCGAGGAACCGCTTGTTTGCCTGTGCTTTTTCATCTGTAAATGGAATGAGTTGGACACAAGATCCAAGCGCCCTCCCCTGTTGGAGAA
GGTTCTTGTGGGCTCTGGGCCCATCCCACATCCCACAGTGGGCAGGAGGCCACCAAGAGGTGCAAGACCATGCCCTCTGTTTCGATAGGA
AGCTGGGCCTCAGAGGGGCCTGGGGCCTGTGTCTGAGACCCGGCCAAGTGCTGGACGTCTCCCCTTCCTCATGGCTGTTATGGCTGAATT
ACGTCCCCCCAAATTCTCATGTTGCAGCCTTAACCCCAGCACCTCAGTGTGGGACTGGGTTTGGAGATGGAGCCCCTACAGAGGTCAGCA
GGTTAAAAGAGGCCATCAGGGCTCTGGGTGGGCCCTGATCCAAGCTGCTTGGTGTCCTTGTAAGAAGAAGAGATGAGGACACAGACACAC
ACAGAGGGACAGCCCCATGAGGAAACAGGGAGGCAATGCCGTCTGCAAGCCCAGGGCAGAGGCCTCAGGAACCAGCCCTGGTGACACCTG
GACCTTGGACCCCCGTGCCCAGGACAGTAGGAGAATTGGAGCCGCCTGGCTGCAGTCCTTCCCGATGGCACCCTGTATTAGTCCGTTCTC
ACACTGCTAATTGTTGGGAAAAGGGCTTGTGGAATGCCTGTATAAACTGGCCATGAAAATATGGGACAATAAGTTGTGGAAAGCCACAAG
AGGCCTCTGAGGAGGAAAGCCTCCTAATTGCCATCATGTTCGCATGCTCAGGGCGAGACCTGCTGTCTTATCTGTAAACACCGTGTTCAA
GGAGAAAGACATTCCTTCGAAGCACTGGACTGTGGACAGACACACGAGCTCCTGGTTAAGCCCGCTCCCACCAGCTCCTGTCCGATAAGT
TAAAGATACGCTGTTTGAGCACAAAGGAGATTCATTGAAACCGCTATTGCTGTAGATTACGCCTGTGACGCACTGCCTCCCTTTCACTGT

>68228_68228_6_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000327574_length(amino acids)=349AA_BP=1
MPTVGCGMGPEPTRTFSNRGGRLDLVSNSFHLQMKKHRQTSGSSGGPRSLALLSDPSRPGSLARPGPSLVSVGRLLARPGPSLVSVGRLL
ALAFSSPAAPCVHTSCPFPAAGTTKPSSRAPVPSPLALHSESQDSATRPPADLQLRRLLPSALSPGSSDRELQEILSKGPLGILATRWRL
CQAQLTVWKNERTLWYGLKERGPGRGKGQKCEQQPRGGEACARWALQALGGSAFPPPSLKGVREPTTQLVWNTRVPAGSLALWPIPGRSC

--------------------------------------------------------------
>68228_68228_7_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000398081_length(transcript)=2585nt_BP=622nt
GGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAAGCGGGCAGAGGAGCTCAAGACTCA
GGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGCAATGCCATCTA
CTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCACGCGGGCCATTGAGCTGGACAAGAA
GTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAGACGGTGGTCAA
GGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAAGGCCTTTGAGCGGGCCATCGCGGG
CGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAGCTTGAAGACGG
CAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCGGAAATGTGCCTACCAGGTTTTGGG
ATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGAGACAAGGTCGGTCTCTGTCGCCCAGGCTGGCGTGAAGTGGCG
CAACCAGCTCACTGCAGCCTTGACCTCCTGGGCTGAAGCAATCTTTCTGCCTCCACCTCCCGAGTGGCTGGGACTATAGTTGTGCACCAG
CACGCCCACCTCCTGCCCAGGGTTGTTACTGGGGTGGTCACGTGGGCAGCTTCTGCCTGGGATGGGCCACAAAGCCAGACTCCCGGCAGG
GACACGGGTGTTCCACACAAGCTGCGTTGTTGGTTCCCTGACGCCCTTCAGGCTGGGGGGTGGGAAAGCCGATCCCCCAAGTGCCTGCAG
AGCCCACCTGGCGCAGGCCTCGCCGCCTCGAGGCTGCTGCTCGCACTTCTGCCCCTTCCCCCGGCCAGGCCCCCGTTCCTTGAGGCCGTA
CCACAAGGTGCGTTCATTTTTCCACACCGTGAGCTGGGCTTGGCAGAGCCTCCACCTTGTGGCCAGTATTCCCAGTGGCCCCTTTGAGAG
GATTTCCTGGAGCTCCCTGTCTGAGCTTCCCGGACTGAGGGCACTGGGAAGGAGCCTGCGGAGCTGGAGGTCAGCGGGTGGACGGGTTGC
GCTGTCCTGGCTTTCGGAGTGTAGAGCCAGAGGGGATGGGACAGGTGCCCTGCTGCTGGGCTTGGTGGTCCCTGCTGCAGGGAAGGGGCA
GCTGGTGTGAACACAAGGAGCTGCGGGGCTGGAGAAGGCCAGGGCCAGGAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAG
GAGCCTGCCGACGGACACCAGCGAGGGGCCAGGCCGGGCCAGACTCCCTGGCCGGCTGGGATCTGACAGGAGTGCCAGGCTCCTTGGGCC
GCCCGAGGAACCGCTTGTTTGCCTGTGCTTTTTCATCTGTAAATGGAATGAGTTGGACACAAGATCCAAGCGCCCTCCCCTGTTGGAGAA
GGTTCTTGTGGGCTCTGGGCCCATCCCACATCCCACAGTGGGCAGGAGGCCACCAAGAGGTGCAAGACCATGCCCTCTGTTTCGATAGGA
AGCTGGGCCTCAGAGGGGCCTGGGGCCTGTGTCTGAGACCCGGCCAAGTGCTGGACGTCTCCCCTTCCTCATGGCTGTTATGGCTGAATT
ACGTCCCCCCAAATTCTCATGTTGCAGCCTTAACCCCAGCACCTCAGTGTGGGACTGGGTTTGGAGATGGAGCCCCTACAGAGGTCAGCA
GGTTAAAAGAGGCCATCAGGGCTCTGGGTGGGCCCTGATCCAAGCTGCTTGGTGTCCTTGTAAGAAGAAGAGATGAGGACACAGACACAC
ACAGAGGGACAGCCCCATGAGGAAACAGGGAGGCAATGCCGTCTGCAAGCCCAGGGCAGAGGCCTCAGGAACCAGCCCTGGTGACACCTG
GACCTTGGACCCCCGTGCCCAGGACAGTAGGAGAATTGGAGCCGCCTGGCTGCAGTCCTTCCCGATGGCACCCTGTATTAGTCCGTTCTC
ACACTGCTAATTGTTGGGAAAAGGGCTTGTGGAATGCCTGTATAAACTGGCCATGAAAATATGGGACAATAAGTTGTGGAAAGCCACAAG
AGGCCTCTGAGGAGGAAAGCCTCCTAATTGCCATCATGTTCGCATGCTCAGGGCGAGACCTGCTGTCTTATCTGTAAACACCGTGTTCAA
GGAGAAAGACATTCCTTCGAAGCACTGGACTGTGGACAGACACACGAGCTCCTGGTTAAGCCCGCTCCCACCAGCTCCTGTCCGATAAGT
TAAAGATACGCTGTTTGAGCACAAAGGAGATTCATTGAAACCGCTATTGCTGTAGATTACGCCTGTGACGCACTGCCTCCCTTTCACTGT

>68228_68228_7_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000398081_length(amino acids)=349AA_BP=1
MPTVGCGMGPEPTRTFSNRGGRLDLVSNSFHLQMKKHRQTSGSSGGPRSLALLSDPSRPGSLARPGPSLVSVGRLLARPGPSLVSVGRLL
ALAFSSPAAPCVHTSCPFPAAGTTKPSSRAPVPSPLALHSESQDSATRPPADLQLRRLLPSALSPGSSDRELQEILSKGPLGILATRWRL
CQAQLTVWKNERTLWYGLKERGPGRGKGQKCEQQPRGGEACARWALQALGGSAFPPPSLKGVREPTTQLVWNTRVPAGSLALWPIPGRSC

--------------------------------------------------------------
>68228_68228_8_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000468090_length(transcript)=7634nt_BP=622nt
GGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAAGCGGGCAGAGGAGCTCAAGACTCA
GGCCAATGACTACTTCAAAGCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGCAATGCCATCTA
CTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCACGCGGGCCATTGAGCTGGACAAGAA
GTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAGACGGTGGTCAA
GGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAAGGCCTTTGAGCGGGCCATCGCGGG
CGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAGCTTGAAGACGG
CAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCGGAAATGTGCCTACCAGGTTTTGGG
ATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGATGAGCT
CCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGTGTGTGATCCAGTCTTGGGTGACAAGTG
GGACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCCGCTTGCAGACATTATCACGCCCAA
CCAGTTTGAGGCCGAGTTACTGAGTGGCCGGAAGATCCACAGCCAGGAGGAAGCCTTGCGGGTGATGGACATGCTGCACTCTATGGGCCC
CGACACCGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATTGTGCTGGGGAGTCAGAGGAGGAGGAATCC
CGCTGGCTCCGTGGTGATGGAACGCATCCGGATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGGCACTGGGGACCTGTTTGCTGCCAT
GCTCCTGGCGTGGACACACAAGCACCCCAATAACCTCAAGGTGGCCTGTGAGAAGACCGTGTCTACCTTGCACCACGTTCTGCAGAGGAC
CATCCAGTGTGCAAAAGCCCAGGCCGGGGAAGGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCGGATGGTGCAGAGCAAAAGGGACAT
CGAGGACCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGAGGGCCCCGCCGCTTGCCCGTGACACGCAGCGCGTTGGTGTCTCCGTGTTT
GTCCCTGTGAAAACATGTAACGTCTGCCTTAGAGCCATGACCGAAACTTGATATTTTTTTCTTTCATGAGTGTCCGGCATCTGCTGGTCT
TCATTGTGAAACGTGCCAGTCGTGCTTTGTGAAAAATAACAAAGTGGTCACAGAAATTTGTGATCTGAAAACCCGGCTCCCTTCCCCACA
AGGCTCCTGGGCCTCCGGGAAGACGGGCCCCTGTTTGCCATCTCGGGGGTGTTCCCTGTGGGAGGGTGAGTGGGTGAGGCCGAGCCTGCT
GCGTGTGGAGCCTCGAGTGGGCCCTGGCTGCCACTACCGTACAGAGGCCGTGTCGCGCTGGGCTGGGCCTGGGTGGCCTCTGTCTTTGCA
TCTCTGAGAAGGAGTCGGGTGGTAACGGTTGGGGTCAGGAAGAATTCTGCCAAGTATCTTTACTGTCATTCTGACCATAGCCTCTTTGTT
CCCGCATTCGAACTTTTGGTTCTTACTTTGCTGCTCGTTTAGTCCCTGGGGATTTCAGATCTTAGGCTGTTGTTTCACCGTATGGGAGGG
TTGATGTGAGCTTGCTTGGAGACACACGGTGCAGCATCAGGGACCTTCCCAGGCCCCAGCAAATTCAAGTCGGTCTGCAGACCTCTCAGC
TACCCGCGGGACCTCTTGTAACCCATCGGCATCTTCCAGGAATCCGCCGAGTGACTTGAGGAAGATGCTAACGCAGTAAGGTCTGTGCTG
GGCCAAGAGCAGCTTTGAAGCTCCAGAGAACCACCCCGTCAGGTTCCTTGTGGAAGCTCCCCTCATCCGTGGTGCAGCAGGCTGAGCACT
GCGCGTTTGCCACGTGCTGCCCGTGACAGCACATTGAGCCACAGCATTTGTAGACAGGACAGAGGGGTGCCTGCCCCCTGCCCCTGCTGG
CACATTTAACCCTTGTCCCCTGACCTCAGTTCTGTGCCCCACCAAATGCCCAGGGGCAAGAGGCCACCCTGGAAGCTGCCAATCTTCCAA
GGTGGGTGTGGGGCACGGTGGGGGCGGGCAGCTCCCAGGCCCTTGGGCAGGCTGGGGTGACGGCAGAGGCCACAGCACCAGCTCTGACAA
GTCCTATCATCCTCTGCTCAGCAGTGACCTCCCTGGCCCCACTTTGCCCAGAGTTTGGGGTCCCCCCAGGTATAGCTATAGGCGGCAGTG
CCTGTCCCTGGCCTGCCTTGATTTCAGCCACACCCCTGCAGCCCTGCATCCCAGCTCTGGGGTGTGCAGAGGTTTGTGTCTCCAGGGAAC
CCACGGCTGGAGAGAAATAGGGAGATGCAGGAAGTGGGGGCCCATGGGGCCCCCAAGAAGCGGACTCTCCAAGGGGTACCCCCACCCCGC
TACCTTCCCCACGGACGGGCCCCTCCTGGAGCCCATACCCTCCTGTGAGGCCATTCCAGTGTCTTCTAGAAAGACTCGCTTGCCAGGAGT
GCGTTCTTTGTTGAAAAATGCCCTGAAGCGAAAAGATGCAGGTTTATATGGAACCCCCACCCCCTCCCCCACTCTCCCACTCTGTTCGTT
CTGAATGTCTTCACGAGCGTGCATCAGGGCGCCTGGCTCCCCCACCTCAGCCAGTGAGTCAGACACGGGTTTCGCAGCCATGTTTCCTGG
CTCCGAGGACACGGGTGGCAGGCCCGTTGCAGCCCAGAGCCACTGGTCCCTACAGGGCGCCGCCACACCAGCAGGAAGGAGGATGGCTGT
GTCCGGAGCCTGGCGGGGAGGCGGCCTCCCCAGTATGTGAGTGCAGGGATCTGCCAGAACCACCTGGCCCTCTGTAGGGCGTTTAACTGG
AAATACCCTCACTGCCAAGTGGAGACTGGGGCGTGTGCCACATTGCCAGCCACCAGGAAAGCTTTTCTTTTTCTTTTTTTTTTTTTTTTA
AACACCAAGAGCACGTATAGCATGGGGGAAAGAACCTAAATGTCTCTCTGTCCTGTGAGCTGGTGAAAAACCCAGCATGAGAACGCAGTG
TCAGGTGTGGGACTCCTTCTGCCCCTGCAGTGGGTGTTACGGGCGGTGTGCCCTGGCGAGCAAGCTTTGATTCTTGGTTCTTTGAGCTCG
TTTCAGAGGCTGAGTCCCCACATCAGCTTTAGTTCTTGGACTTCCCTGTATTAAGCAAGAATTAGGAGAATGGCTGTCCCTGCAGGCGCC
TCCCGTAAATCCTGAGCTCTCTGGCGCAATCTGAAACTTCTCTTCTGTTTTCTTTGGCTGTATCAGCCGAACCAGGAGAGGCCTGGGCTG
CGACTAAGGAGAAAGAAATCGGGGGTTTCTGAGAGCAGATGGTGCCTTTGTGGGTGCAGGGCTTTTGTGGAAATTGTCAGCCTCTACGGG
CAGAGTCCGGCATCCCCTCCCCAGACTGCCTGCTGTCAAACCACGGAGCAGCTGGAGCCTGCCCTGTCCACGGCCCGTTTCCACCCGGGC
ATGTTCGTCTCTCCTGACTTCGGCAGAGGCCCCTGGTGGCCTTCAGTTTCAGTTTCTCATCCAGGAAGGTAACCTTGGGCATTGGCAGTG
GGTTTCCCTATGGCTTGGATCCAGATTAGAATTGATCTTTGTTTTCACTTTCCATAGTTAATAACATGCAAAATAATGAGAAGAATTTAT
TTTAAGGTGACAGCTATACTGGTCCAACATCGCCTGCTTATTGTCAGGGTACAGAAGTTTAATACTTTCTTAATCCAGTTTTTCAAACTT
CTCCCTGTAGACCGTAAGGATGAATTCCACAATAGGATCCTTTTTAAAATCGATTTTAAATTGTTGCCTAGTCCTGCCAAGGTTATTATG
TGCATCTGTTATTTTTCCAATACATGTAAACAGTTGCAGCATGATGCTTTGTTTAATGTCCTGTTCTTAAGCTCGTTAGAGCCAGTTTTG
AAACGTTTGGTCTTACCGTGAACGGAGGCTGGCTTGGCTTAGCCACGCTGATGAGTAAGTGAGGGATGTCTCCATCTTGAGATCACCAGG
CAAGAGAGTTGCCTGCACCAGGTAAGAGGCCAAAGCCCCTGGGGTAACAGTCCCCACCGCTACCCGAGGTAAAACAATAAAAGCTATGTG
GTTGAGCTCAGGCCTCTCGTGCCTGGTGTCAGAGAAGGCAGAGCCCACAGTAGGTGCACGGTGCAAGGCCCTGGGAGGGCACTGGCCAGG
GAAGGTGGTATAGATGGCCCTCAGATTGCGGGGCCCCGAGCAGCTCCCCACTCTGCCCGTCCACCTTCCCTGGCTCCAGCCTCATTCTCT
CTTTAGTTTAACTATGCAAAGAGAGGAGGTTGAGAGTGTTCTGGCAGCTGGAGCTCTTTTCCTTGTCCTTCCTGCCCTCCGATGGGGCCA
CCTGTGTCGGGGCAGCAGTGTCCATGTTTATGGAGATCAGAGGTGTCCCCACTGTGTGGCTGGACTGTACTCTGCTGCCCGGGTAGCCAG
GAGTCTCTCCCTCTCTCCCCTGCCGCCTGCCTGGTCTCATGGGCCTCCTTCACACACCCCTCCCTGTGGATCGCCTGCCTGGGCCCAGAG
CAGGGGAACTGGAGTTTGTGAGTGAGCAGAGCAGGTTATGTGCAGACAGGGAAACGAGAACTTTGGACCTGGCTTTCTGAGTCCAGGTGA
GAGCTGTGTGGCCCCCCGATGCCACTCTGCCCGCCGGAGGGATGTGCCTGCTGAGCCTTTTCCTTCCACGCCGCCTCTCACTGCCAGGCC
AGCGGCTTCCGCTGAGACTCGCTGGAGAGGCGGCTCCCGTGTCCGTCCACCGAGCACTCAGATGGATGCTGATCACCAGGGCCGAGGGGG
CTCCCAGAAGGACCCCAGGCCCTGGGGAGGGTGGCTGTGGGAGGCCAAGTCCACTGCCCGGAAGTCTTGTCAGCCCTAAGCCAGGGAAGC
CTGGAGCGTGGCCTGGCGGGTCTGGGTGGACACCGTCCCCACTCCGGACTCCCAGCACAGGGGAGGATACCTGAGCCTGTATGGCCCTGT
AGCCCTGGGCAGAGCTGGGCCTGTCGTGTGTTCCTGCCTGGCAGGTGCAGGTGCTGGCCATCTGCAGGTGGAAGGAGGTGGGAATCTTGG
ATTTTTTGTTTTTTTTTGTTTTTTTTTTTTTGAGGTGAAGTCTCGCTCTGACACCCAGGCTGGCGTGCAGTGGTGTGATCTCGGCTCACT
GCAAACTCCGCTTCCTGGGTTCAAGTGGTTCTCCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACGCTCAGCTGA
TTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCT
CCCAGAGTGCTGGGATTACAGGCATGAGCCAGTGCACCCGGCGGAATCTTGGAATTTTTATAGACAGCACCTCAGTTTCTGACTCCAGCC
GCACACCTCCTGCCTCTGCCAGCAGGGGTTGCCGCCAGACCAGAGCCAGGGCCAGGTCCCTGCGTCCATCCCCCCCGGTAGGATGGACGT
GAGCCATCCTTCTAGGGGACTTTTTTCAGTGTGCGACTCGTCTCTGTTAGGTGGTAGGAGCCAGTTTGTGTGGCCTGTGCCACGCTCCAC
AGTGCGTGGCTGGGCTCTGTGTGTGGCCTGTGTCCCCTGTCCCTGCAGGACCCAGCAGGCATCGTGGCGTGACAGCTGTGTCCAAGCCAC
TGCCCGGGCATCCCATCACCCACCAGGGTGCACGGTCTCTCCTGCTGGGGGCTTTCTGTCGCATGTGTGTCTCCTGTCGACTCTGCAGTT
TGTTCTCAGAGCAGAATGTTTCCTGTTCTCAGTGCACAAAGACACTGGTTTTCAATCGGCGTCTAAAACCACGTTCCTGCCTTTCATTGC
AACACGGTGTGTTCATTTGTTTAAAACAGTTTAATGAGTAAGTTTAGATGACTGGTCAATATCTTAAAAATGTATATTAGTAAGAAGTTC
TTCCTGGAATTTTTCTTTCGATTCTGGCAGAATAAACAGGTGTTTTTAGTTTTCCCACTGTCTGAGCCAAGCAGGACCCTGTCCCAGAGC
AAGAGATGTCCCCTTCCATCTCTGACCCTTGCCTGGGACAAGCTTTGATGGGGGGCCCCAGCTTCAAGGCTGTGGTGGGAACAGCACCCC
CAAATGCCAGCCTCTCCTTTCTTCCCATCCACCAGTATACTGCGGGGCCATTTCTGGTCTTTGTCCAACAGGAAACCCATTTCTGGTGGG
ATATGCCTTCCAGTGCCACAGGGCCACTCACCCCATGCATCTCTGTCCTGCCCGTCAGTGCTGGGACGGACAGCAAGGGCAAGCCCAGTG
TCTGGCGGATAGGTGGGTGGGAACAGAGAGGGGAGAATGCCGTCCTAAGCTTCTGCTTGGGGATCCCCCACACGACCTGGGTACTGCCTG
GGAAACCTGTCCTAAGTAAAACTATGGACCTCGCCTCGCCCACCGGCCTGCGAAGCCAGCATCTCCGTGAAGGTGGATGGAAGCGCCTTT
GTCCTCATTTTGAGCTGCAAGCTGGGTCAGCGGCTCTGAAGCCCTCGAGTGACTTTCTAACCCAAGACCCAGCCCCTGGCAGGAGGAGGG
TGGGTGCAGGGCTGGTGGGACAAAAAGAGGCCTCAGCAGGCCTGGAAGACCCTTCCAGTACATCCCACAGCGTGTCGAGCAGCTGGGAGA
ACCTGTGTCAAGCTCGAGCCGTCATAGGTCCCCATGAGGTGTCTGAAGCCCCTTCTTGGTGATGGGAGGCAGAGGTGCTGACGTTCTGGA
GCATGGACGTGAGTCCTCAGCTGGCTCCGCGTGGGCCCTTGGAGGGTGCCAGGTGTGTGGTGACCTTCTGGATGCCTTTAACTTCATGGC
TGCGTCATTCCTGATTTAGAACTTTAACCGGAGCTTCATCTAGTGATTGCAAAACTGGACCAATGGGAGGACGGCGGCGCAGCCCGCTCC
CTCCGTGGAATGGAGCTCAGCTCTTCGGAGGCATCAAAGCACCTGTCGCCTCCGTGGTCCCCCTGCTGAGGGAGTGCGGCCTCTGCAAGG
TTCGGGGGTGGCTTCGTTTGCCTGGAGTGGCCGGCCCTGCTTGTGCCATGTGGATGTTTGTGAGCCTCGGTCCTACAGCACTGTGTAGGC

>68228_68228_8_PPP5C-PDXK_PPP5C_chr19_46879831_ENST00000391919_PDXK_chr21_45153949_ENST00000468090_length(amino acids)=442AA_BP=186
MKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRA
ALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKL
HRKCAYQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTVCDPVLGDKWDGEGSMYVPEDLLPVYKEKV
VPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVF

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Fusion Gene PPI Analysis for PPP5C-PDXK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP5C-PDXK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP5C-PDXK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource