Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP6R1-EPS8L1 (FusionGDB2 ID:68240)

Fusion Gene Summary for PPP6R1-EPS8L1

Fusion gene summary

Fusion gene information	Fusion gene name: PPP6R1-EPS8L1
	Fusion gene ID: 68240
		Hgene	Tgene
	Gene symbol	PPP6R1	EPS8L1
	Gene ID	22870	54869
	Gene name	protein phosphatase 6 regulatory subunit 1	EPS8 like 1
	Synonyms	KIAA1115\|PP6R1\|SAP190\|SAPS1	DRC3\|EPS8R1\|PP10566
	Cytomap	19q13.42	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 6 regulatory subunit 1SAPS domain family, member 1	epidermal growth factor receptor kinase substrate 8-like protein 1EPS8-like protein 1EPS8-related protein 1epidermal growth factor receptor pathway substrate 8-related protein 1
	Modification date	20200313	20200320
	UniProtAcc	.	Q8TE68
	Ensembl transtripts involved in fusion gene	ENST00000412770, ENST00000587283,	ENST00000201647, ENST00000245618, ENST00000540810, ENST00000588359, ENST00000592824, ENST00000586329,
Fusion gene scores	* DoF score	10 X 9 X 5=450	2 X 2 X 1=4
	# samples	11	2
	** MAII score	log2(11/450*10)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: PPP6R1 [Title/Abstract] AND EPS8L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP6R1(55750772)-EPS8L1(55597208), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP6R1	GO:0043666	regulation of phosphoprotein phosphatase activity	16716191
Tgene	EPS8L1	GO:0007266	Rho protein signal transduction	14565974
Tgene	EPS8L1	GO:0035023	regulation of Rho protein signal transduction	14565974

Fusion gene breakpoints across PPP6R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPS8L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-SW-A7EA	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+

Top

Fusion Gene ORF analysis for PPP6R1-EPS8L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000412770	ENST00000201647	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000412770	ENST00000245618	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000412770	ENST00000540810	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000412770	ENST00000588359	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000412770	ENST00000592824	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000587283	ENST00000201647	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000587283	ENST00000245618	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000587283	ENST00000540810	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000587283	ENST00000588359	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
5CDS-intron	ENST00000587283	ENST00000592824	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
In-frame	ENST00000412770	ENST00000586329	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+
In-frame	ENST00000587283	ENST00000586329	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000412770

PPP6R1

chr19

55750772

ENST00000586329

EPS8L1

chr19

55597208

2843

2318

567

2537

656

ENST00000587283

PPP6R1

chr19

55750772

ENST00000586329

EPS8L1

chr19

55597208

2545

2020

2239

718

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000412770	ENST00000586329	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+	0.019090656	0.98090935
ENST00000587283	ENST00000586329	PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+	0.026895015	0.973105

Top

Fusion Genomic Features for PPP6R1-EPS8L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+	2.84E-06	0.99999714
PPP6R1	chr19	55750772	-	EPS8L1	chr19	55597208	+	2.84E-06	0.99999714

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PPP6R1-EPS8L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:55750772/chr19:55597208)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EPS8L1 Q8TE68
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269\|PubMed:14565974}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000201647

689_719

461

724.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000245618

689_719

334

597.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000201647

534_576

461

724.0

Compositional bias

Note=Pro-rich

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000245618

448_451

334

597.0

Compositional bias

Note=Poly-Arg

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000245618

534_576

334

597.0

Compositional bias

Note=Pro-rich

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000201647

478_537

461

724.0

Domain

SH3

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000245618

478_537

334

597.0

Domain

SH3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000412770

624_631

583

882.0

Compositional bias

Note=Poly-Glu

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000412770

624_685

583

882.0

Compositional bias

Note=Glu-rich

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000412770

671_685

583

882.0

Compositional bias

Note=Poly-Glu

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000412770

697_878

583

882.0

Compositional bias

Note=Pro-rich

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000587283

624_631

583

882.0

Compositional bias

Note=Poly-Glu

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000587283

624_685

583

882.0

Compositional bias

Note=Glu-rich

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000587283

671_685

583

882.0

Compositional bias

Note=Poly-Glu

Hgene

PPP6R1

chr19:55750772

chr19:55597208

ENST00000587283

697_878

583

882.0

Compositional bias

Note=Pro-rich

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000201647

119_122

461

724.0

Compositional bias

Note=Poly-Leu

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000201647

448_451

461

724.0

Compositional bias

Note=Poly-Arg

Tgene

EPS8L1

chr19:55750772

chr19:55597208

ENST00000245618

119_122

334

597.0

Compositional bias

Note=Poly-Leu

Top

Fusion Gene Sequence for PPP6R1-EPS8L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68240_68240_1_PPP6R1-EPS8L1_PPP6R1_chr19_55750772_ENST00000412770_EPS8L1_chr19_55597208_ENST00000586329_length(transcript)=2843nt_BP=2318nt
GAGCCGGGCGTCGGAGGCCCTGAGGCCGGCCGCAGAGCCCGGAGATTGAGCGGCTTTGGGGAAGGGGTGGTTAAGGAAGTAGGCCTCGGC
TTCCGTCGGTCGCTGCTCGGCTCTGCGGCCCGTTTGGACCGCGGAGGAGGTCGCCTTCCCCTCCCGTGGGGCGCTCGGTTGGACTGTGGA
AACCGGGGCAACTTCCCCCGTCTTCCCGGCTGAGGCGCCTGCGTGGGCCTCGCGACCCGGCTCGCCAACCCGCCTCGGCCCGCACGCCCA
CCTCGCCTGCGGACCCCGGAGGTGCCTACGCGGACTAGTGACGCCCCCCGCCCGTCGGCAACTCCACCCGGCGCTGACCCCCTCAACTCT
GCAGGACCCGGCGCGCGAGGACCCCACGACCCGCGGGCGCCTGCGCGGACCCCGCGAGCCCCGGCGCCTGCGCGAGTCCCCGACGCCGCC
CCCGCCCCCACTCACCGGGCCCCGCAGCAGGGGCCGGAGCCGCCGGCGGCGGGGCGGGGGGGGGCGCCCCGATGAGCCCCGAGTGCGAGG
AGCCGCCGCCCCCCCTCGCAGGGCGCCATGTTTTGGAAGTTTGACCTGCACACAAGCTCGCACCTGGACACGCTGCTGGAGCGGGAGGAC
CTGAGCCTGCCCGAGCTGCTGGACGAGGAAGACGTGCTGCAGGAGTGCAAGGTCGTCAACCGCAAGCTGCTGGACTTCCTGCTGCAGCCA
CCCCACCTGCAAGCAATGGTGGCCTGGGTCACCCAGGAGCCGCCAGATAGCGGTGAGGAGCGGCTGCGCTACAAGTACCCCAGTGTGGCC
TGCGAGATTCTGACCTCAGATGTGCCCCAGATCAATGATGCCCTGGGTGCTGATGAGTCCCTTCTGAACCGGCTCTACGGCTTCCTGCAG
AGCACCGGCAGCCTCAACCCACTGCTGGCCAGCTTCTTCAGCAAGGTCATGGGCATCCTCATCAACCGCAAGACAGACCAGCTCGTGTCC
TTTCTTCGGAAGAAGGATGACTTCGTGGACCTGCTGCTGCAGCACATTGGCACCTCGGCCATCATGGACCTCCTGCTGCGCCTGCTCACC
TGTGTGGAGCGGCCTCAGCTGAGGCAGGATGTTGTCAATTGGCTCAACGAGGAGAAGATCGTCCAGCGGCTGATTGAGCAGATCCACCCG
TCGAAGGATGAGAATCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGAC
AGCCCAGAGCCTGACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGC
CAGTCTGTCATCGTCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTC
TTCAGCAGTGTGGATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGC
CCGCGGCTCAGCTGCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTG
GGCAACACGCGGCTGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGAC
GTGCCCAACACCATGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTG
AGCTTGGGGCCACCTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAG
CGGATCCTGACGTCCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCC
GGTGCCCTGGTGCAGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAG
TGGGAAGCCTTCGTATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGT
GACGATGAGGACGACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATG
ACCTCTGCCTTCATTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAATCACCGAGACTTGGAGCCAGAA
TCTGAGCCTCAGCTGGAGTCAGAGACAGCAGGAAAATGGGTCCTGTGTAATTATGACTTCCAGGCCCGCAACAGCAGTGAGCTGTCGGTC
AAGCAGCGGGACGTACTGGAGGACAAAGAGAAAGTGTCAGAGCTGGAGGCAGTGATGGAGAAGCAAAAGAAGAAGGTGGAAGGCGAGGTG
GAAATGGAGGTCATTTGACCTGCCAGGCGCCCTTCGCAAAGAGTGACGAGGCCCCGTGGGAGAACGGACTCCTCAGACTCTCCCCAATAG
CGGAAGTCGATCTTCTGAAGGATGGCCAATCTGCTCCGGCCCTGGTCTTCCCCCATCCCGGTGGACAGACTTAACGATCCTTGCTGCAGT
CCCTCCGGAGAGGATCTGGACTGGCTGGGAGTGGGGAGGGCGTGGAGACAGTCTACGGAAAGCGCTAGCAGACCCCCGAGAGGGTGCAGT

>68240_68240_1_PPP6R1-EPS8L1_PPP6R1_chr19_55750772_ENST00000412770_EPS8L1_chr19_55597208_ENST00000586329_length(amino acids)=656AA_BP=584
MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVP
QINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQ
DVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQ
VLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVK
LLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEEN
DRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKE
FNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEDK

--------------------------------------------------------------
>68240_68240_2_PPP6R1-EPS8L1_PPP6R1_chr19_55750772_ENST00000587283_EPS8L1_chr19_55597208_ENST00000586329_length(transcript)=2545nt_BP=2020nt
GGAGGCTGGAGATGGGGGAAGAGGGGCAGGCTCGAGGGCAACTGCAGGAGCCTGGTGCTCACTGGGAGCCTTAAGCCTGAGTGATGGAGG
CAGTGAGCCTGCGGGCAGTCCCGGGGCGGGGCCGGGCTCAGCATGAGGCAGAGGGCTGGGACTTGGGGAGAGGCTGTGCCCAAGGTGGGC
ACTCAGCCCCTGTGGTCAGTGCCTCGTCCAGTGGGGACTCCCTGGGGCGTCTGACGCGGCGCTGGTTGTGTCTATGCCTGCAGGGCGCCA
TGTTTTGGAAGTTTGACCTGCACACAAGCTCGCACCTGGACACGCTGCTGGAGCGGGAGGACCTGAGCCTGCCCGAGCTGCTGGACGAGG
AAGACGTGCTGCAGGAGTGCAAGGTCGTCAACCGCAAGCTGCTGGACTTCCTGCTGCAGCCACCCCACCTGCAAGCAATGGTGGCCTGGG
TCACCCAGGAGCCGCCAGATAGCGGTGAGGAGCGGCTGCGCTACAAGTACCCCAGTGTGGCCTGCGAGATTCTGACCTCAGATGTGCCCC
AGATCAATGATGCCCTGGGTGCTGATGAGTCCCTTCTGAACCGGCTCTACGGCTTCCTGCAGAGCACCGGCAGCCTCAACCCACTGCTGG
CCAGCTTCTTCAGCAAGGTCATGGGCATCCTCATCAACCGCAAGACAGACCAGCTCGTGTCCTTTCTTCGGAAGAAGGATGACTTCGTGG
ACCTGCTGCTGCAGCACATTGGCACCTCGGCCATCATGGACCTCCTGCTGCGCCTGCTCACCTGTGTGGAGCGGCCTCAGCTGAGGCAGG
ATGTTGTCAATTGGCTCAACGAGGAGAAGATCGTCCAGCGGCTGATTGAGCAGATCCACCCGTCGAAGGATGAGAATCAACATTCCAACG
CATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCA
CCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGG
TGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGC
TCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCC
TGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGC
TCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCT
TCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCC
CTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACG
ACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGG
GGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGG
CGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGT
TCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCT
TCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAATCACCGAGACTTGGAGCCAGAATCTGAGCCTCAGCTGGAGTCAGAGACAG
CAGGAAAATGGGTCCTGTGTAATTATGACTTCCAGGCCCGCAACAGCAGTGAGCTGTCGGTCAAGCAGCGGGACGTACTGGAGGACAAAG
AGAAAGTGTCAGAGCTGGAGGCAGTGATGGAGAAGCAAAAGAAGAAGGTGGAAGGCGAGGTGGAAATGGAGGTCATTTGACCTGCCAGGC
GCCCTTCGCAAAGAGTGACGAGGCCCCGTGGGAGAACGGACTCCTCAGACTCTCCCCAATAGCGGAAGTCGATCTTCTGAAGGATGGCCA
ATCTGCTCCGGCCCTGGTCTTCCCCCATCCCGGTGGACAGACTTAACGATCCTTGCTGCAGTCCCTCCGGAGAGGATCTGGACTGGCTGG
GAGTGGGGAGGGCGTGGAGACAGTCTACGGAAAGCGCTAGCAGACCCCCGAGAGGGTGCAGTGGAGCCCTGAGCATTGTAATATGCGGCC

>68240_68240_2_PPP6R1-EPS8L1_PPP6R1_chr19_55750772_ENST00000587283_EPS8L1_chr19_55597208_ENST00000586329_length(amino acids)=718AA_BP=646
MEAVSLRAVPGRGRAQHEAEGWDLGRGCAQGGHSAPVVSASSSGDSLGRLTRRWLCLCLQGAMFWKFDLHTSSHLDTLLEREDLSLPELL
DEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNP
LLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQH
SNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQ
LELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLD
LFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNT
EKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP6R1-EPS8L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	PPP6R1	chr19:55750772	chr19:55597208	ENST00000412770	-	15	24	10_403	583.6666666666666	882.0	PPP6C
Hgene	PPP6R1	chr19:55750772	chr19:55597208	ENST00000587283	-	14	23	10_403	583.6666666666666	882.0	PPP6C

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPP6R1-EPS8L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPP6R1-EPS8L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source