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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP6R2-CBX1 (FusionGDB2 ID:68251)

Fusion Gene Summary for PPP6R2-CBX1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R2-CBX1
Fusion gene ID: 68251
HgeneTgene
Gene symbol

PPP6R2

CBX1

Gene ID

9701

10951

Gene nameprotein phosphatase 6 regulatory subunit 2chromobox 1
SynonymsKIAA0685|PP6R2|SAP190|SAPS2CBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta
Cytomap

22q13.33

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 2SAPS domain family, member 2chromobox protein homolog 1HP1 beta homologchromobox homolog 1 (HP1 beta homolog Drosophila )heterochromatin protein 1 homolog betaheterochromatin protein 1-betaheterochromatin protein p25 betamodifier 1 protein
Modification date2020031320200313
UniProtAcc.

P83916

Ensembl transtripts involved in fusion geneENST00000216061, ENST00000359139, 
ENST00000395741, ENST00000395744, 
ENST00000225603, ENST00000393408, 
ENST00000495350, 
Fusion gene scores* DoF score30 X 15 X 13=58509 X 7 X 5=315
# samples 3111
** MAII scorelog2(31/5850*10)=-4.23809650408389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP6R2 [Title/Abstract] AND CBX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP6R2(50845304)-CBX1(46152462), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP6R2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A3KG-01APPP6R2chr22

50845304

-CBX1chr17

46152462

-
ChimerDB4LIHCTCGA-BC-A3KG-01APPP6R2chr22

50845304

+CBX1chr17

46152462

-
ChimerDB4LIHCTCGA-BC-A3KGPPP6R2chr22

50845304

+CBX1chr17

46152462

-


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Fusion Gene ORF analysis for PPP6R2-CBX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216061ENST00000225603PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000216061ENST00000393408PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000216061ENST00000495350PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000359139ENST00000225603PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000359139ENST00000393408PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000359139ENST00000495350PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395741ENST00000225603PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395741ENST00000393408PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395741ENST00000495350PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395744ENST00000225603PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395744ENST00000393408PPP6R2chr22

50845304

+CBX1chr17

46152462

-
In-frameENST00000395744ENST00000495350PPP6R2chr22

50845304

+CBX1chr17

46152462

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359139PPP6R2chr2250845304+ENST00000393408CBX1chr1746152462-24318083941047217
ENST00000359139PPP6R2chr2250845304+ENST00000225603CBX1chr1746152462-24318083941047217
ENST00000359139PPP6R2chr2250845304+ENST00000495350CBX1chr1746152462-983808394906170
ENST00000395741PPP6R2chr2250845304+ENST00000393408CBX1chr1746152462-24127893751028217
ENST00000395741PPP6R2chr2250845304+ENST00000225603CBX1chr1746152462-24127893751028217
ENST00000395741PPP6R2chr2250845304+ENST00000495350CBX1chr1746152462-964789375887170
ENST00000395744PPP6R2chr2250845304+ENST00000393408CBX1chr1746152462-24047813671020217
ENST00000395744PPP6R2chr2250845304+ENST00000225603CBX1chr1746152462-24047813671020217
ENST00000395744PPP6R2chr2250845304+ENST00000495350CBX1chr1746152462-956781367879170
ENST00000216061PPP6R2chr2250845304+ENST00000393408CBX1chr1746152462-24077843071023238
ENST00000216061PPP6R2chr2250845304+ENST00000225603CBX1chr1746152462-24077843071023238
ENST00000216061PPP6R2chr2250845304+ENST00000495350CBX1chr1746152462-959784307882191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359139ENST00000393408PPP6R2chr2250845304+CBX1chr1746152462-0.0012264470.9987735
ENST00000359139ENST00000225603PPP6R2chr2250845304+CBX1chr1746152462-0.0012264470.9987735
ENST00000359139ENST00000495350PPP6R2chr2250845304+CBX1chr1746152462-0.0041780440.99582195
ENST00000395741ENST00000393408PPP6R2chr2250845304+CBX1chr1746152462-0.0011809270.99881905
ENST00000395741ENST00000225603PPP6R2chr2250845304+CBX1chr1746152462-0.0011809270.99881905
ENST00000395741ENST00000495350PPP6R2chr2250845304+CBX1chr1746152462-0.0039418450.9960582
ENST00000395744ENST00000393408PPP6R2chr2250845304+CBX1chr1746152462-0.0009545020.99904543
ENST00000395744ENST00000225603PPP6R2chr2250845304+CBX1chr1746152462-0.0009545020.99904543
ENST00000395744ENST00000495350PPP6R2chr2250845304+CBX1chr1746152462-0.003241650.9967584
ENST00000216061ENST00000393408PPP6R2chr2250845304+CBX1chr1746152462-0.0008910970.99910885
ENST00000216061ENST00000225603PPP6R2chr2250845304+CBX1chr1746152462-0.0008910970.99910885
ENST00000216061ENST00000495350PPP6R2chr2250845304+CBX1chr1746152462-0.0016441650.9983558

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Fusion Genomic Features for PPP6R2-CBX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP6R2-CBX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50845304/chr17:46152462)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBX1

P83916

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCBX1chr22:50845304chr17:46152462ENST0000022560325117_175106186.0DomainChromo 2%3B shadow subtype
TgeneCBX1chr22:50845304chr17:46152462ENST0000039340825117_175106186.0DomainChromo 2%3B shadow subtype

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP6R2chr22:50845304chr17:46152462ENST00000216061+525820_825138967.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr17:46152462ENST00000359139+423820_825138928.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr17:46152462ENST00000395741+423820_825138934.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr17:46152462ENST00000395744+423820_825138933.0Compositional biasNote=Poly-Ser
TgeneCBX1chr22:50845304chr17:46152462ENST000002256032521_79106186.0DomainChromo 1
TgeneCBX1chr22:50845304chr17:46152462ENST000003934082521_79106186.0DomainChromo 1


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Fusion Gene Sequence for PPP6R2-CBX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68251_68251_1_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000225603_length(transcript)=2407nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCG
AGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGA
CCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTC
GGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGA
AGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCA
AGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTG
CACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTT
CAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATT
ACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGG
GGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCAC
CATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTT
CCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAG
TATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATAT
CAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCA
TGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACA
AGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACT
TTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAAC
CATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTT

>68251_68251_1_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000225603_length(amino acids)=238AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATD

--------------------------------------------------------------
>68251_68251_2_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000393408_length(transcript)=2407nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCG
AGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGA
CCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTC
GGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGA
AGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCA
AGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTG
CACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTT
CAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATT
ACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGG
GGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCAC
CATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTT
CCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAG
TATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATAT
CAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCA
TGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACA
AGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACT
TTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAAC
CATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTT

>68251_68251_2_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000393408_length(amino acids)=238AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATD

--------------------------------------------------------------
>68251_68251_3_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000495350_length(transcript)=959nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCG
AGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGTGAGTCGGCCAGTGGCTCTG

>68251_68251_3_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000216061_CBX1_chr17_46152462_ENST00000495350_length(amino acids)=191AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATD

--------------------------------------------------------------
>68251_68251_4_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000225603_length(transcript)=2431nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTC
AGAAAAGCCACGAGGCTTTGCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAA
ATGGAAAAACTCTGATGAGGCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAG
GCTGACGTGGCATTCCTACCCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGA
CTGTGGGTTTCAAGTGGGAAGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATA
GTTTCTGTGCCCTGCAGCAGCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATA
AGTGTTTCAAGGCAACCTTTTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGA
GAGCAAAAAAATACTGTAGATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTA
GCATGTGTGTAGTTTTTGGCTATTACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTT
GATTAACATTTGGGGCCTGATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTA
CCTTTAAAAAAATGTCATTGGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGT
TCCCTGCCTAAACTTATTGCTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAG
GAGGGAAGGTCTTTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTT
TTCCAGTAACGAAGTTATAAATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAG
ACAGTAGGGAAAGACAAGGGCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGG
CAGGGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAAC
TTTCATATTGGGCAGTGGTTCACTTTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAA
TGCTCTGTCTTGAGTCATGAGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTG
TTAGATTTCTGTGTAAACTTTGTTTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTCTTAATAAAACTATAGATTTATAATCCCTG

>68251_68251_4_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000225603_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_5_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000393408_length(transcript)=2431nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTC
AGAAAAGCCACGAGGCTTTGCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAA
ATGGAAAAACTCTGATGAGGCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAG
GCTGACGTGGCATTCCTACCCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGA
CTGTGGGTTTCAAGTGGGAAGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATA
GTTTCTGTGCCCTGCAGCAGCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATA
AGTGTTTCAAGGCAACCTTTTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGA
GAGCAAAAAAATACTGTAGATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTA
GCATGTGTGTAGTTTTTGGCTATTACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTT
GATTAACATTTGGGGCCTGATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTA
CCTTTAAAAAAATGTCATTGGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGT
TCCCTGCCTAAACTTATTGCTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAG
GAGGGAAGGTCTTTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTT
TTCCAGTAACGAAGTTATAAATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAG
ACAGTAGGGAAAGACAAGGGCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGG
CAGGGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAAC
TTTCATATTGGGCAGTGGTTCACTTTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAA
TGCTCTGTCTTGAGTCATGAGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTG
TTAGATTTCTGTGTAAACTTTGTTTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTCTTAATAAAACTATAGATTTATAATCCCTG

>68251_68251_5_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000393408_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_6_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000495350_length(transcript)=983nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTC
AGAAAAGCCACGAGGCTTTGCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAA

>68251_68251_6_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000359139_CBX1_chr17_46152462_ENST00000495350_length(amino acids)=170AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP

--------------------------------------------------------------
>68251_68251_7_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000225603_length(transcript)=2412nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTT
GCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAG
GCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTAC
CCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGA
AGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCA
GCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTT
TTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAG
ATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGG
CTATTACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTG
ATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATT
GGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTG
CTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTG
GAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATA
AATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGG
GCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACA
GCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGT
TCACTTTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATG
AGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACT

>68251_68251_7_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000225603_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_8_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000393408_length(transcript)=2412nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTT
GCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAG
GCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTAC
CCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGA
AGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCA
GCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTT
TTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAG
ATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGG
CTATTACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTG
ATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATT
GGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTG
CTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTG
GAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATA
AATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGG
GCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACA
GCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGT
TCACTTTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATG
AGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACT

>68251_68251_8_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000393408_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_9_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000495350_length(transcript)=964nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTT
GCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGTGAGTCGGCCAGTGG

>68251_68251_9_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395741_CBX1_chr17_46152462_ENST00000495350_length(amino acids)=170AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP

--------------------------------------------------------------
>68251_68251_10_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000225603_length(transcript)=2404nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCGAGG
TTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGACCT
GGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTCGGA
GGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGAAGG
AGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCAAGT
GCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTGCAC
TTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTTCAA
AGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATTACT
GGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGGGGA
AATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCACCAT
AAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTTCCC
ACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAGTAT
ACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATATCAG
CTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCATGC
TCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACAAGT
TTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACTTTA
AAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAACCAT
CAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTTTAA

>68251_68251_10_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000225603_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_11_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000393408_length(transcript)=2404nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCGAGG
TTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGACCT
GGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTCGGA
GGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGAAGG
AGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCAAGT
GCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTGCAC
TTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTTCAA
AGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATTACT
GGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGGGGA
AATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCACCAT
AAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTTCCC
ACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAGTAT
ACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATATCAG
CTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCATGC
TCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACAAGT
TTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACTTTA
AAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAACCAT
CAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTTTAA

>68251_68251_11_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000393408_length(amino acids)=217AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQSEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVP

--------------------------------------------------------------
>68251_68251_12_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000495350_length(transcript)=956nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGTCAGAAAAGCCACGAGGCTTTGCTCGAGG
TTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGTGAGTCGGCCAGTGGCTCTGTGT

>68251_68251_12_PPP6R2-CBX1_PPP6R2_chr22_50845304_ENST00000395744_CBX1_chr17_46152462_ENST00000495350_length(amino acids)=170AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP6R2-CBX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP6R2-CBX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP6R2-CBX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource