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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP6R2-EMID1 (FusionGDB2 ID:68252)

Fusion Gene Summary for PPP6R2-EMID1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R2-EMID1
Fusion gene ID: 68252
HgeneTgene
Gene symbol

PPP6R2

EMID1

Gene ID

9701

129080

Gene nameprotein phosphatase 6 regulatory subunit 2EMI domain containing 1
SynonymsKIAA0685|PP6R2|SAP190|SAPS2EMI5|EMU1
Cytomap

22q13.33

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 2SAPS domain family, member 2EMI domain-containing protein 1emilin and multimerin domain-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q96A84

Ensembl transtripts involved in fusion geneENST00000216061, ENST00000359139, 
ENST00000395741, ENST00000395744, 
ENST00000484039, ENST00000334018, 
ENST00000404755, ENST00000404820, 
Fusion gene scores* DoF score30 X 15 X 13=58509 X 12 X 7=756
# samples 3112
** MAII scorelog2(31/5850*10)=-4.23809650408389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP6R2 [Title/Abstract] AND EMID1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP6R2(50845304)-EMID1(29627009), # samples:2
PPP6R2(50845304)-EMID1(29621122), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP6R2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EMID1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A1G1-01APPP6R2chr22

50845304

-EMID1chr22

29621122

+
ChimerDB4BRCATCGA-A2-A1G1-01APPP6R2chr22

50845304

+EMID1chr22

29621122

+
ChimerDB4BRCATCGA-A2-A1G1-01APPP6R2chr22

50845304

+EMID1chr22

29627009

+


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Fusion Gene ORF analysis for PPP6R2-EMID1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000216061ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29621122

+
5CDS-3UTRENST00000216061ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29627009

+
5CDS-3UTRENST00000359139ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29621122

+
5CDS-3UTRENST00000359139ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29627009

+
5CDS-3UTRENST00000395741ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29621122

+
5CDS-3UTRENST00000395741ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29627009

+
5CDS-3UTRENST00000395744ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29621122

+
5CDS-3UTRENST00000395744ENST00000484039PPP6R2chr22

50845304

+EMID1chr22

29627009

+
Frame-shiftENST00000216061ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000216061ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000216061ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000359139ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000359139ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000359139ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395741ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395741ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395741ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395744ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395744ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29621122

+
Frame-shiftENST00000395744ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29621122

+
In-frameENST00000216061ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000216061ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000216061ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000359139ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000359139ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000359139ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395741ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395741ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395741ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395744ENST00000334018PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395744ENST00000404755PPP6R2chr22

50845304

+EMID1chr22

29627009

+
In-frameENST00000395744ENST00000404820PPP6R2chr22

50845304

+EMID1chr22

29627009

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359139PPP6R2chr2250845304+ENST00000334018EMID1chr2229627009+23288083941674426
ENST00000359139PPP6R2chr2250845304+ENST00000404820EMID1chr2229627009+23348083941680428
ENST00000359139PPP6R2chr2250845304+ENST00000404755EMID1chr2229627009+22658083941611405
ENST00000395741PPP6R2chr2250845304+ENST00000334018EMID1chr2229627009+23097893751655426
ENST00000395741PPP6R2chr2250845304+ENST00000404820EMID1chr2229627009+23157893751661428
ENST00000395741PPP6R2chr2250845304+ENST00000404755EMID1chr2229627009+22467893751592405
ENST00000395744PPP6R2chr2250845304+ENST00000334018EMID1chr2229627009+23017813671647426
ENST00000395744PPP6R2chr2250845304+ENST00000404820EMID1chr2229627009+23077813671653428
ENST00000395744PPP6R2chr2250845304+ENST00000404755EMID1chr2229627009+22387813671584405
ENST00000216061PPP6R2chr2250845304+ENST00000334018EMID1chr2229627009+23047843071650447
ENST00000216061PPP6R2chr2250845304+ENST00000404820EMID1chr2229627009+23107843071656449
ENST00000216061PPP6R2chr2250845304+ENST00000404755EMID1chr2229627009+22417843071587426

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359139ENST00000334018PPP6R2chr2250845304+EMID1chr2229627009+0.0830872360.91691273
ENST00000359139ENST00000404820PPP6R2chr2250845304+EMID1chr2229627009+0.129562850.87043715
ENST00000359139ENST00000404755PPP6R2chr2250845304+EMID1chr2229627009+0.07291510.92708486
ENST00000395741ENST00000334018PPP6R2chr2250845304+EMID1chr2229627009+0.081064490.9189355
ENST00000395741ENST00000404820PPP6R2chr2250845304+EMID1chr2229627009+0.126723570.8732765
ENST00000395741ENST00000404755PPP6R2chr2250845304+EMID1chr2229627009+0.0716779750.92832196
ENST00000395744ENST00000334018PPP6R2chr2250845304+EMID1chr2229627009+0.078661940.9213381
ENST00000395744ENST00000404820PPP6R2chr2250845304+EMID1chr2229627009+0.1237353160.8762647
ENST00000395744ENST00000404755PPP6R2chr2250845304+EMID1chr2229627009+0.070260920.92973906
ENST00000216061ENST00000334018PPP6R2chr2250845304+EMID1chr2229627009+0.06476320.93523675
ENST00000216061ENST00000404820PPP6R2chr2250845304+EMID1chr2229627009+0.1050642360.8949358
ENST00000216061ENST00000404755PPP6R2chr2250845304+EMID1chr2229627009+0.061360830.93863916

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Fusion Genomic Features for PPP6R2-EMID1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP6R2chr2250845304+EMID1chr2229621121+3.78E-050.9999622
PPP6R2chr2250845304+EMID1chr2229627008+3.72E-091
PPP6R2chr2250845304+EMID1chr2229621121+3.78E-050.9999622
PPP6R2chr2250845304+EMID1chr2229627008+3.72E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP6R2-EMID1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50845304/chr22:29627009)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EMID1

Q96A84

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEMID1chr22:50845304chr22:29627009ENST00000334018415179_368155444.0DomainNote=Collagen-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP6R2chr22:50845304chr22:29627009ENST00000216061+525820_825138967.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr22:29627009ENST00000359139+423820_825138928.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr22:29627009ENST00000395741+423820_825138934.0Compositional biasNote=Poly-Ser
HgenePPP6R2chr22:50845304chr22:29627009ENST00000395744+423820_825138933.0Compositional biasNote=Poly-Ser
TgeneEMID1chr22:50845304chr22:29627009ENST0000033401841533_106155444.0DomainEMI


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Fusion Gene Sequence for PPP6R2-EMID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68252_68252_1_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000334018_length(transcript)=2304nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCA
GCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCT
CCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCC
ACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCC
TCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCAC
TGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGG
TGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGG
ACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGG
GGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGA
GCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGT
GGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGC
CAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGT
CCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGG
CCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGG
CTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCC
TTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCC
TCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGA

>68252_68252_1_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000334018_length(amino acids)=447AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDP
APLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGP
PHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAG

--------------------------------------------------------------
>68252_68252_2_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000404755_length(transcript)=2241nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCA
GCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCT
CCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCC
ACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCC
TCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCAC
TGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGG
TGTCCCTGGGAGTCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGG
AGACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGA
AACAATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGG
CGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCC
AGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCT
AGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTT
TCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAA
AGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTC
GGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCAC
CGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCG

>68252_68252_2_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000404755_length(amino acids)=426AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDP
APLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGP
PHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGL

--------------------------------------------------------------
>68252_68252_3_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000404820_length(transcript)=2310nt_BP=784nt
ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT
GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT
TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG
CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC
GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT
AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT
GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG
TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA
TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCA
GCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCT
CCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCC
ACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCC
TCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCAC
TGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGG
TGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGG
ACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGC
TCCTAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCAGCTGGAGCTCCTGGCCAGACGGGTCACCCTCCTGGAAGCCATCATCTGGCCAGA
ACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCG
GATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGA
CTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGT
CTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGA
GGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAG
CTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCT
CCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTT
CTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGT

>68252_68252_3_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000216061_EMID1_chr22_29627009_ENST00000404820_length(amino acids)=449AA_BP=158
MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM
EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDP
APLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGP
PHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAG

--------------------------------------------------------------
>68252_68252_4_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000334018_length(transcript)=2328nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGAT
GACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCA
GGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCG
GGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAG
GGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGA
CCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCC
CCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCA
CCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGA
CCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAAC
AATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGG
ACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGG
CTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGG
CCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCC
CTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGG
CACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGG
GAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGG
GGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCT

>68252_68252_4_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000334018_length(amino acids)=426AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGL

--------------------------------------------------------------
>68252_68252_5_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000404755_length(transcript)=2265nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGAT
GACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCA
GGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCG
GGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAG
GGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGA
CCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCC
CCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCA
GCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTT
AGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCC
CAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTG
GCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATG
TCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTG
AGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATC
TGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTT
CCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGC
TGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGAT
GGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGATGCCAGGAGGTAGATGTGTGCTGGCCAATAAAGGCCCCT

>68252_68252_5_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000404755_length(amino acids)=405AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMI

--------------------------------------------------------------
>68252_68252_6_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000404820_length(transcript)=2334nt_BP=808nt
GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC
GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC
CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA
CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC
AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA
GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG
CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA
CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT
CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGAT
GACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCA
GGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCG
GGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAG
GGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGA
CCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCC
CCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCA
CCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGA
CCCTGGTGAGAAGAGCCACTGGGCTCCTAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCAGCTGGAGCTCCTGGCCAGACGGGTCACCCT
CCTGGAAGCCATCATCTGGCCAGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAG
GGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAG
GCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCA
TCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCA
GTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCC
CAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAAC
CTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGAT
CACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGG

>68252_68252_6_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000359139_EMID1_chr22_29627009_ENST00000404820_length(amino acids)=428AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSL

--------------------------------------------------------------
>68252_68252_7_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000334018_length(transcript)=2309nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATA
GAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGA
GGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGA
GGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCA
GGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACC
TTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCC
ACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAG
AGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCAC
TGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAA
CCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGG
ATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGAC
TCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTC
TCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAG
GCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGC
TGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTC
CCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTC
TTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTG

>68252_68252_7_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000334018_length(amino acids)=426AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGL

--------------------------------------------------------------
>68252_68252_8_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000404755_length(transcript)=2246nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATA
GAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGA
GGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGA
GGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCA
GGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACC
TTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCC
ACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCT
AAGGGAGACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATC
TTGGAAACAATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAG
AGGGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACC
AGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGC
CATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCT
CAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGG
CCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAA
ACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGG
ATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGG

>68252_68252_8_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000404755_length(amino acids)=405AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMI

--------------------------------------------------------------
>68252_68252_9_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000404820_length(transcript)=2315nt_BP=789nt
CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG
CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT
CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC
TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC
TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG
GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG
GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG
ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT
CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATA
GAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGA
GGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGA
GGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCA
GGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACC
TTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCC
ACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAG
AGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCAC
TGGGCTCCTAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCAGCTGGAGCTCCTGGCCAGACGGGTCACCCTCCTGGAAGCCATCATCTGG
CCAGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAAC
TACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTAC
CTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAG
CAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGG
GGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTC
AGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTG
CCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCT
CAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATG

>68252_68252_9_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395741_EMID1_chr22_29627009_ENST00000404820_length(amino acids)=428AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSL

--------------------------------------------------------------
>68252_68252_10_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000334018_length(transcript)=2301nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCAGCC
AGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCA
GGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACC
AGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCC
TGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGA
GACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGT
CCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACT
GCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGGGGA
GGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGAGCT
GGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTGGC
CCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAG
CTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCT
GGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCT
TCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTC
GGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTG
TTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCT
GAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGATGC

>68252_68252_10_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000334018_length(amino acids)=426AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGL

--------------------------------------------------------------
>68252_68252_11_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000404755_length(transcript)=2238nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCAGCC
AGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCA
GGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACC
AGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCC
TGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGA
GACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGT
CCCTGGGAGTCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGA
CCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAAC
AATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGG
ACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGG
CTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGG
CCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCC
CTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGG
CACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGG
GAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGG
GGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCT

>68252_68252_11_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000404755_length(amino acids)=405AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMI

--------------------------------------------------------------
>68252_68252_12_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000404820_length(transcript)=2307nt_BP=781nt
CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC
TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG
GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT
GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC
CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT
GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT
GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA
TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC
TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGATGACCATGCTGACTGTCATAGAGCAGCC
AGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCA
GGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACC
AGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCC
TGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGA
GACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGT
CCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACT
GCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGCTCC
TAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCAGCTGGAGCTCCTGGCCAGACGGGTCACCCTCCTGGAAGCCATCATCTGGCCAGAACC
AGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGAT
CGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTC
GGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTC
AGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGC
AGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTG
GGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCC
TCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTT
CCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGAC

>68252_68252_12_PPP6R2-EMID1_PPP6R2_chr22_50845304_ENST00000395744_EMID1_chr22_29627009_ENST00000404820_length(amino acids)=428AA_BP=137
MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP
QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQ
VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETN
NHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP6R2-EMID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP6R2-EMID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP6R2-EMID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource