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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PPP6R2-SQSTM1 (FusionGDB2 ID:68278) |
Fusion Gene Summary for PPP6R2-SQSTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP6R2-SQSTM1 | Fusion gene ID: 68278 | Hgene | Tgene | Gene symbol | PPP6R2 | SQSTM1 | Gene ID | 9701 | 8878 |
| Gene name | protein phosphatase 6 regulatory subunit 2 | sequestosome 1 | |
| Synonyms | KIAA0685|PP6R2|SAP190|SAPS2 | A170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62B | |
| Cytomap | 22q13.33 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 6 regulatory subunit 2SAPS domain family, member 2 | sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | Q13501 | |
| Ensembl transtripts involved in fusion gene | ENST00000216061, ENST00000359139, ENST00000395741, ENST00000395744, | ENST00000360718, ENST00000389805, ENST00000402874, ENST00000506690, ENST00000510187, ENST00000376929, | |
| Fusion gene scores | * DoF score | 30 X 15 X 13=5850 | 33 X 21 X 17=11781 |
| # samples | 31 | 38 | |
| ** MAII score | log2(31/5850*10)=-4.23809650408389 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/11781*10)=-4.95431877505661 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP6R2 [Title/Abstract] AND SQSTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PPP6R2(50877126)-SQSTM1(179250921), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SQSTM1 | GO:0006914 | autophagy | 20452972 |
| Tgene | SQSTM1 | GO:0007032 | endosome organization | 27368102 |
| Tgene | SQSTM1 | GO:0031397 | negative regulation of protein ubiquitination | 20452972 |
| Tgene | SQSTM1 | GO:0061635 | regulation of protein complex stability | 25127057 |
| Tgene | SQSTM1 | GO:1905719 | protein localization to perinuclear region of cytoplasm | 27368102 |
| Fusion gene breakpoints across PPP6R2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SQSTM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | CF127724 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
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Fusion Gene ORF analysis for PPP6R2-SQSTM1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000216061 | ENST00000360718 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000216061 | ENST00000389805 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000216061 | ENST00000402874 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000216061 | ENST00000506690 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000216061 | ENST00000510187 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000359139 | ENST00000360718 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000359139 | ENST00000389805 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000359139 | ENST00000402874 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000359139 | ENST00000506690 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000359139 | ENST00000510187 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395741 | ENST00000360718 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395741 | ENST00000389805 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395741 | ENST00000402874 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395741 | ENST00000506690 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395741 | ENST00000510187 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395744 | ENST00000360718 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395744 | ENST00000389805 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395744 | ENST00000402874 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395744 | ENST00000506690 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| 5CDS-intron | ENST00000395744 | ENST00000510187 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| In-frame | ENST00000216061 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| In-frame | ENST00000359139 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| In-frame | ENST00000395741 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| In-frame | ENST00000395744 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000359139 | PPP6R2 | chr22 | 50877126 | + | ENST00000376929 | SQSTM1 | chr5 | 179250921 | + | 4782 | 2342 | 394 | 2355 | 653 |
| ENST00000395741 | PPP6R2 | chr22 | 50877126 | + | ENST00000376929 | SQSTM1 | chr5 | 179250921 | + | 4766 | 2326 | 375 | 2339 | 654 |
| ENST00000395744 | PPP6R2 | chr22 | 50877126 | + | ENST00000376929 | SQSTM1 | chr5 | 179250921 | + | 4755 | 2315 | 367 | 2328 | 653 |
| ENST00000216061 | PPP6R2 | chr22 | 50877126 | + | ENST00000376929 | SQSTM1 | chr5 | 179250921 | + | 4839 | 2399 | 307 | 2412 | 701 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000359139 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + | 0.008521847 | 0.99147815 |
| ENST00000395741 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + | 0.008024532 | 0.9919755 |
| ENST00000395744 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + | 0.008276786 | 0.99172324 |
| ENST00000216061 | ENST00000376929 | PPP6R2 | chr22 | 50877126 | + | SQSTM1 | chr5 | 179250921 | + | 0.007319777 | 0.9926802 |
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Fusion Genomic Features for PPP6R2-SQSTM1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PPP6R2-SQSTM1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50877126/chr5:179250921) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | SQSTM1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 272_294 | 0 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 272_294 | 0 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 272_294 | 0 | 441.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 272_294 | 0 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 389_434 | 0 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 3_102 | 0 | 357.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 389_434 | 0 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 3_102 | 0 | 357.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 389_434 | 0 | 441.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 3_102 | 0 | 441.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 389_434 | 0 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 3_102 | 0 | 357.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 228_233 | 0 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 336_341 | 0 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 228_233 | 0 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 336_341 | 0 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 228_233 | 0 | 441.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 336_341 | 0 | 441.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 228_233 | 0 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 336_341 | 0 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 170_220 | 0 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 321_342 | 0 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 170_220 | 0 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 321_342 | 0 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 170_220 | 0 | 441.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 321_342 | 0 | 441.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 170_220 | 0 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 321_342 | 0 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 122_167 | 0 | 357.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 122_167 | 0 | 357.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 122_167 | 0 | 441.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 122_167 | 0 | 357.0 | Zinc finger | ZZ-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP6R2 | chr22:50877126 | chr5:179250921 | ENST00000216061 | + | 1 | 25 | 820_825 | 0 | 967.0 | Compositional bias | Note=Poly-Ser |
| Hgene | PPP6R2 | chr22:50877126 | chr5:179250921 | ENST00000359139 | + | 1 | 23 | 820_825 | 0 | 928.0 | Compositional bias | Note=Poly-Ser |
| Hgene | PPP6R2 | chr22:50877126 | chr5:179250921 | ENST00000395741 | + | 1 | 23 | 820_825 | 0 | 934.0 | Compositional bias | Note=Poly-Ser |
| Hgene | PPP6R2 | chr22:50877126 | chr5:179250921 | ENST00000395744 | + | 1 | 23 | 820_825 | 0 | 933.0 | Compositional bias | Note=Poly-Ser |
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Fusion Gene Sequence for PPP6R2-SQSTM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >68278_68278_1_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000216061_SQSTM1_chr5_179250921_ENST00000376929_length(transcript)=4839nt_BP=2399nt ATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGGGCGCTTTCAT GGAACTATATGATCATATGGGCAACATTCTGTTGCAGTCTACCTTCTGTCTGACGGATATGCCATCCTGAAAAAGGAAAGAAGCTGAACT TCAAGTTCCTTTCATTTAGCCTTGGGCTTCCACCTTCTCTGTGGCTAGAAACAGGACCGTCCAGAAGTCACCTGTAACTGCCCTATCTTG CAAGTTCTGATTTTGGCAAAAAAAAAAAAAAAAAGCCTTGACAAGGTTGGATTCACTTCTTTCCCTGGATTGTGTGTCATCCAACTCTGC GGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTT AATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCT GGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTG TGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAA TCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGGTGATTACGTTTTTGAAGAAGAAGGA CAAGTTCATCAGCCTGGTGTTGAAGCACATCGGCACCTCAGCGCTTATGGACCTGCTGCTGCGCCTGGTCAGCTGTGTGGAGCCAGCCGG GCTCCGGCAGGACGTCCTGCACTGGCTGAATGAAGAGAAGGTCATCCAGAGGCTTGTGGAGTTGATCCACCCGAGCCAGGATGAAGATAG GCAGTCAAATGCTTCTCAGACTCTCTGTGACATAGTTAGGCTGGGCAGAGACCAGGGCAGTCAGCTGCAAGAGGCTCTGGAGCCAGACCC GCTCCTCACAGCGCTGGAGTCGCAGGACTGTGTGGAGCAGCTTCTGAAGAACATGTTTGATGGAGACCGGACGGAGAGCTGCCTCGTCAG TGGGACTCAGGTGTTACTCACCTTGCTGGAAACCAGGCGGGTTGGGACAGAGGGCTTGGTGGACTCCTTTTCTCAGGGACTGGAAAGGTC ATACGCTGTCAGCAGCAGCGTACTACACGGCATCGAGCCTCGGCTGAAGGACTTCCACCAGCTCCTGCTCAACCCGCCCAAGAAGAAAGC GATCCTGACCACCATTGGTGTGCTGGAGGAGCCCCTGGGGAATGCCCGTCTGCATGGCGCCCGCCTCATGGCAGCACTGCTGCACACAAA CACACCCAGCATCAACCAGGAGCTCTGCCGGCTCAACACGATGGACTTACTGCTGGACTTGTTCTTTAAGTACACCTGGAATAACTTTTT GCACTTCCAAGTGGAACTATGCATAGCCGCTATTCTCTCCCACGCTGCCCGTGAGGAGAGGACAGAAGCCAGCGGATCCGAGAGCAGGGT GGAGCCTCCGCATGAGAACGGGAACCGGAGCCTGGAGACTCCCCAGCCGGCCGCCAGCCTCCCTGACAACACAATGGTGACCCACCTGTT CCAGAAGTGCTGCCTGGTGCAGAGGATCCTGGAGGCCTGGGAAGCCAACGACCACACGCAGGCAGCGGGTGGCATGAGACGTGGGAACAT GGGCCACCTCACACGGATCGCCAACGCGGTGGTGCAGAACCTGGAGCGGGGCCCTGTGCAGACGCACATCAGCGAGGTCATCCGAGGGCT CCCTGCGGACTGCCGTGGCCGCTGGGAGAGCTTCGTGGAGGAGACGCTGACGGAGACGAACCGCAGGAACACTGTGGACCTGGTGAGCAC TCACCACCTTCACTCCTCAAGTGAGGACGAGGACATTGAGGGTGCTTTCCCTAACGAGCTGTCCCTTCAGCAGGCCTTCTCTGACTACCA GATCCAGCAGATGACAGCCAACTTCGTGGATCAGTTTGGCTTCAATGATGAGGAGTTTGCCGACCAGGACGACAACATCAATGCCCCGTT TGACAGGATCGCAGAGATCAACTTCAACATCGACGCTGACGAGGACAGTCCCAGCGCAGCTCTGTTTGAGGCCTGCTGCAGTGACCGCAT CCAGCCCTTTGATGATGATGAGGACGAGGACATCTGGGAGGACAGTGACACTCGCTGTGCTGCCCGGGTGATGGCCAGACCCAGTGGGGC AGGTGCCCCACCGGCCCCCGGGAAGAAGGAAGCGCCCCCTGTGGAGGGTGACTCAGAAGGCACCCCAATGTGATCTGCGATGGCTGCAAT GGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGG CACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACAC TTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCA GAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGGC ATTGAAGTTGATATCGATGTGGAGCACGGAGGGAAAAGAAGCCGCCTGACCCCCGTCTCTCCAGAGAGTTCCAGCACAGAGGAGAAGAGC AGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACGCAGTCTCTGGCGGAGCAGATGAGG AAGATCGCCTTGGAGTCCGAGGGGCGCCCTGAGGAACAGATGGAGTCGGATAACTGTTCAGGAGGAGATGATGACTGGACCCATCTGTCT TCAAAAGAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAG GGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCACATCTCCCGCCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAGATGCTG TCCATGGGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAACTATGACATCGGAGCGGCTCTGGACACCATCCAG TATTCAAAGCATCCCCCGCCGTTGTGACCACTTTTGCCCACCTCTTCTGCGTGCCCCTCTTCTGTCTCATAGTTGTGTTAAGCTTGCGTA GAATTGCAGGTCTCTGTACGGGCCAGTTTCTCTGCCTTCTTCCAGGATCAGGGGTTAGGGTGCAAGAAGCCATTTAGGGCAGCAAAACAA GTGACATGAAGGGAGGGTCCCTGTGTGTGTGTGTGCTGATGTTTCCTGGGTGCCCTGGCTCCTTGCAGCAGGGCTGGGCCTGCGAGACCC AAGGCTCACTGCAGCGCGCTCCTGACCCCTCCCTGCAGGGGCTACGTTAGCAGCCCAGCACATAGCTTGCCTAATGGCTTTCACTTTCTC TTTTGTTTTAAATGACTCATAGGTCCCTGACATTTAGTTGATTATTTTCTGCTACAGACCTGGTACACTCTGATTTTAGATAAAGTAAGC CTAGGTGTTGTCAGCAGGCAGGCTGGGGAGGCCAGTGTTGTGGGCTTCCTGCTGGGACTGAGAAGGCTCACGAAGGGCATCCGCAATGTT GGTTTCACTGAGAGCTGCCTCCTGGTCTCTTCACCACTGTAGTTCTCTCATTTCCAAACCATCAGCTGCTTTTAAAATAAGATCTCTTTG TAGCCATCCTGTTAAATTTGTAAACAATCTAATTAAATGGCATCAGCACTTTAACCAATGACGTTTGCATAGAGAGAAATGATTGACAGT AAGTTTATTGTTAATGGTTCTTACAGAGTATCTTTAAAAGTGCCTTAGGGGAACCCTGTCCCTCCTAACAAGTGTATCTCGATTAATAAC CTGCCAGTCCCAGATCACACATCATCATCGAAGTCTTCCCCAGTTATAAAGAGGTCACATAGTCGTGTGGGTCGAGGATTCTGTGCCTCC AGGACCAGGGGCCCACCCTCTGCCCAGGGAGTCCTTGCGTCCCATGAGGTCTTCCCGCAAGGCCTCTCAGACCCAGATGTGACGGGGTGT GTGGCCCGAGGAAGCTGGACAGCGGCAGTGGGCCTGCTGAGGCCTTCTCTTGAGGCCTGTGCTCTGGGGGTCCCTTGCTTAGCCTGTGCT GGACCAGCTGGCCTGGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGTGAACTTTTTCTAGGTGGCAGGACAAATTGCGCC CATTTAGAGGATGTGGCTGTAACCTGCTGGATGGGACTCCATAGCTCCTTCCCAGGACCCCTCAGCTCCCCGGCACTGCAGTCTGCAGAG TTCTCCTGGAGGCAGGGGCTGCTGCCTTGTTTCACCTTCCATGTCAGGCCAGCCTGTCCCTGAAAGAGAAGATGGCCATGCCCTCCATGT GTAAGAACAATGCCAGGGCCCAGGAGGACCGCCTGCCCTGCCTGGGCCTTGGCTGGGCCTCTGGTTCTGACACTTTCTGCTGGAAGCTGT >68278_68278_1_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000216061_SQSTM1_chr5_179250921_ENST00000376929_length(amino acids)=701AA_BP= MTRLDSLLSLDCVSSNSAAVTMFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDM EEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGT SALMDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESQDCVE QLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPL GNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLE TPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFV EETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDA -------------------------------------------------------------- >68278_68278_2_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000359139_SQSTM1_chr5_179250921_ENST00000376929_length(transcript)=4782nt_BP=2342nt GGAGCGCGTGCCCGTGCGCCGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCC GTGCCGGTGTCCGTAGGCGCTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCC CTGGCCTCCGCTCGGGCCTCCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCA CTGAATGAAAAAAATTTTCTTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAAC AAGAGATTTCCACAGAAGCTCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAA GGAGCATGTGACGCTGCAGGAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTG CAGGCAGCAGTGCATGGAGGAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAA CACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTT CTTGGACCATGAGCCGCCTCTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGGT GATTACGTTTTTGAAGAAGAAGGACAAGTTCATCAGCCTGGTGTTGAAGCACATCGGCACCTCAGCGCTTATGGACCTGCTGCTGCGCCT GGTCAGCTGTGTGGAGCCAGCCGGGCTCCGGCAGGACGTCCTGCACTGGCTGAATGAAGAGAAGGTCATCCAGAGGCTTGTGGAGTTGAT CCACCCGAGCCAGGATGAAGATAGGCAGTCAAATGCTTCTCAGACTCTCTGTGACATAGTTAGGCTGGGCAGAGACCAGGGCAGTCAGCT GCAAGAGGCTCTGGAGCCAGACCCGCTCCTCACAGCGCTGGAGTCGCAGGACTGTGTGGAGCAGCTTCTGAAGAACATGTTTGATGGAGA CCGGACGGAGAGCTGCCTCGTCAGTGGGACTCAGGTGTTACTCACCTTGCTGGAAACCAGGCGGGTTGGGACAGAGGGCTTGGTGGACTC CTTTTCTCAGGGACTGGAAAGGTCATACGCTGTCAGCAGCAGCGTACTACACGGCATCGAGCCTCGGCTGAAGGACTTCCACCAGCTCCT GCTCAACCCGCCCAAGAAGAAAGCGATCCTGACCACCATTGGTGTGCTGGAGGAGCCCCTGGGGAATGCCCGTCTGCATGGCGCCCGCCT CATGGCAGCACTGCTGCACACAAACACACCCAGCATCAACCAGGAGCTCTGCCGGCTCAACACGATGGACTTACTGCTGGACTTGTTCTT TAAGTACACCTGGAATAACTTTTTGCACTTCCAAGTGGAACTATGCATAGCCGCTATTCTCTCCCACGCTGCCCGTGAGGAGAGGACAGA AGCCAGCGGATCCGAGAGCAGGGTGGAGCCTCCGCATGAGAACGGGAACCGGAGCCTGGAGACTCCCCAGCCGGCCGCCAGCCTCCCTGA CAACACAATGGTGACCCACCTGTTCCAGAAGTGCTGCCTGGTGCAGAGGATCCTGGAGGCCTGGGAAGCCAACGACCACACGCAGGCAGC GGGTGGCATGAGACGTGGGAACATGGGCCACCTCACACGGATCGCCAACGCGGTGGTGCAGAACCTGGAGCGGGGCCCTGTGCAGACGCA CATCAGCGAGGTCATCCGAGGGCTCCCTGCGGACTGCCGTGGCCGCTGGGAGAGCTTCGTGGAGGAGACGCTGACGGAGACGAACCGCAG GAACACTGTGGACCTGGCCTTCTCTGACTACCAGATCCAGCAGATGACAGCCAACTTCGTGGATCAGTTTGGCTTCAATGATGAGGAGTT TGCCGACCAGGACGACAACATCAATGCCCCGTTTGACAGGATCGCAGAGATCAACTTCAACATCGACGCTGACGAGGACAGTCCCAGCGC AGCTCTGTTTGAGGCCTGCTGCAGTGACCGCATCCAGCCCTTTGATGATGATGAGGACGAGGACATCTGGGAGGACAGTGACACTCGCTG TGCTGCCCGGGTGATGGCCAGACCCAGTGGGGCAGGTGCCCCACCGGCCCCCGGGAAGAAGGAAGCGCCCCCTGTGGAGGGTGACTCAGA AGGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTGT AGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCAC AGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCCT CGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGGG GAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGGCATTGAAGTTGATATCGATGTGGAGCACGGAGGGAAAAGAAGCCGCCTGACCCCCGTC TCTCCAGAGAGTTCCAGCACAGAGGAGAAGAGCAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAG GGCGCCACGCAGTCTCTGGCGGAGCAGATGAGGAAGATCGCCTTGGAGTCCGAGGGGCGCCCTGAGGAACAGATGGAGTCGGATAACTGT TCAGGAGGAGATGATGACTGGACCCATCTGTCTTCAAAAGAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCC GAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCACATCTCCCGCCAGAGGCTGAC CCGCGGCTGATTGAGTCCCTCTCCCAGATGCTGTCCATGGGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAAC TATGACATCGGAGCGGCTCTGGACACCATCCAGTATTCAAAGCATCCCCCGCCGTTGTGACCACTTTTGCCCACCTCTTCTGCGTGCCCC TCTTCTGTCTCATAGTTGTGTTAAGCTTGCGTAGAATTGCAGGTCTCTGTACGGGCCAGTTTCTCTGCCTTCTTCCAGGATCAGGGGTTA GGGTGCAAGAAGCCATTTAGGGCAGCAAAACAAGTGACATGAAGGGAGGGTCCCTGTGTGTGTGTGTGCTGATGTTTCCTGGGTGCCCTG GCTCCTTGCAGCAGGGCTGGGCCTGCGAGACCCAAGGCTCACTGCAGCGCGCTCCTGACCCCTCCCTGCAGGGGCTACGTTAGCAGCCCA GCACATAGCTTGCCTAATGGCTTTCACTTTCTCTTTTGTTTTAAATGACTCATAGGTCCCTGACATTTAGTTGATTATTTTCTGCTACAG ACCTGGTACACTCTGATTTTAGATAAAGTAAGCCTAGGTGTTGTCAGCAGGCAGGCTGGGGAGGCCAGTGTTGTGGGCTTCCTGCTGGGA CTGAGAAGGCTCACGAAGGGCATCCGCAATGTTGGTTTCACTGAGAGCTGCCTCCTGGTCTCTTCACCACTGTAGTTCTCTCATTTCCAA ACCATCAGCTGCTTTTAAAATAAGATCTCTTTGTAGCCATCCTGTTAAATTTGTAAACAATCTAATTAAATGGCATCAGCACTTTAACCA ATGACGTTTGCATAGAGAGAAATGATTGACAGTAAGTTTATTGTTAATGGTTCTTACAGAGTATCTTTAAAAGTGCCTTAGGGGAACCCT GTCCCTCCTAACAAGTGTATCTCGATTAATAACCTGCCAGTCCCAGATCACACATCATCATCGAAGTCTTCCCCAGTTATAAAGAGGTCA CATAGTCGTGTGGGTCGAGGATTCTGTGCCTCCAGGACCAGGGGCCCACCCTCTGCCCAGGGAGTCCTTGCGTCCCATGAGGTCTTCCCG CAAGGCCTCTCAGACCCAGATGTGACGGGGTGTGTGGCCCGAGGAAGCTGGACAGCGGCAGTGGGCCTGCTGAGGCCTTCTCTTGAGGCC TGTGCTCTGGGGGTCCCTTGCTTAGCCTGTGCTGGACCAGCTGGCCTGGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGT GAACTTTTTCTAGGTGGCAGGACAAATTGCGCCCATTTAGAGGATGTGGCTGTAACCTGCTGGATGGGACTCCATAGCTCCTTCCCAGGA CCCCTCAGCTCCCCGGCACTGCAGTCTGCAGAGTTCTCCTGGAGGCAGGGGCTGCTGCCTTGTTTCACCTTCCATGTCAGGCCAGCCTGT CCCTGAAAGAGAAGATGGCCATGCCCTCCATGTGTAAGAACAATGCCAGGGCCCAGGAGGACCGCCTGCCCTGCCTGGGCCTTGGCTGGG CCTCTGGTTCTGACACTTTCTGCTGGAAGCTGTCAGGCTGGGACAGGCTTTGATTTTGAGGGTTAGCAAGACAAAGCAAATAAATGCCTT >68278_68278_2_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000359139_SQSTM1_chr5_179250921_ENST00000376929_length(amino acids)=653AA_BP= MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGTQ VLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPS INQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQKC CLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDYQ IQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDEDIWEDSDTRCAARVMARPSGA -------------------------------------------------------------- >68278_68278_3_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000395741_SQSTM1_chr5_179250921_ENST00000376929_length(transcript)=4766nt_BP=2326nt CGCCGCCGCCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCG CTGCGCCCTCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCT CCACACGGGCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTC TTAAAGCTGCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGC TCTGCGGCCGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAG GAGTTAATGGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAG GAGCTGGTGAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTG ACTTGTGATGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCT CTCAATCCTCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGGTGATTACGTTTTTGAAGAAG AAGGACAAGTTCATCAGCCTGGTGTTGAAGCACATCGGCACCTCAGCGCTTATGGACCTGCTGCTGCGCCTGGTCAGCTGTGTGGAGCCA GCCGGGCTCCGGCAGGACGTCCTGCACTGGCTGAATGAAGAGAAGGTCATCCAGAGGCTTGTGGAGTTGATCCACCCGAGCCAGGATGAA GATAGGCAGTCAAATGCTTCTCAGACTCTCTGTGACATAGTTAGGCTGGGCAGAGACCAGGGCAGTCAGCTGCAAGAGGCTCTGGAGCCA GACCCGCTCCTCACAGCGCTGGAGTCCAGGCAGGACTGTGTGGAGCAGCTTCTGAAGAACATGTTTGATGGAGACCGGACGGAGAGCTGC CTCGTCAGTGGGACTCAGGTGTTACTCACCTTGCTGGAAACCAGGCGGGTTGGGACAGAGGGCTTGGTGGACTCCTTTTCTCAGGGACTG GAAAGGTCATACGCTGTCAGCAGCAGCGTACTACACGGCATCGAGCCTCGGCTGAAGGACTTCCACCAGCTCCTGCTCAACCCGCCCAAG AAGAAAGCGATCCTGACCACCATTGGTGTGCTGGAGGAGCCCCTGGGGAATGCCCGTCTGCATGGCGCCCGCCTCATGGCAGCACTGCTG CACACAAACACACCCAGCATCAACCAGGAGCTCTGCCGGCTCAACACGATGGACTTACTGCTGGACTTGTTCTTTAAGTACACCTGGAAT AACTTTTTGCACTTCCAAGTGGAACTATGCATAGCCGCTATTCTCTCCCACGCTGCCCGTGAGGAGAGGACAGAAGCCAGCGGATCCGAG AGCAGGGTGGAGCCTCCGCATGAGAACGGGAACCGGAGCCTGGAGACTCCCCAGCCGGCCGCCAGCCTCCCTGACAACACAATGGTGACC CACCTGTTCCAGAAGTGCTGCCTGGTGCAGAGGATCCTGGAGGCCTGGGAAGCCAACGACCACACGCAGGCAGCGGGTGGCATGAGACGT GGGAACATGGGCCACCTCACACGGATCGCCAACGCGGTGGTGCAGAACCTGGAGCGGGGCCCTGTGCAGACGCACATCAGCGAGGTCATC CGAGGGCTCCCTGCGGACTGCCGTGGCCGCTGGGAGAGCTTCGTGGAGGAGACGCTGACGGAGACGAACCGCAGGAACACTGTGGACCTG GCCTTCTCTGACTACCAGATCCAGCAGATGACAGCCAACTTCGTGGATCAGTTTGGCTTCAATGATGAGGAGTTTGCCGACCAGGACGAC AACATCAATGCCCCGTTTGACAGGATCGCAGAGATCAACTTCAACATCGACGCTGACGAGGACAGTCCCAGCGCAGCTCTGTTTGAGGCC TGCTGCAGTGACCGCATCCAGCCCTTTGATGATGATGAGGACGAGGACATCTGGGAGGACAGTGACACTCGCTGTGCTGCCCGGGTGATG GCCAGACCCAGTGGGGCAGGTGCCCCACCGGCCCCCGGGAAGAAGGAAGCGCCCCCTGTGGAGGGTGACTCAGAAGGCACCCCAATGTGA TCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAA AGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGA AGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCC GCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTG CCCTTAGCCCTCTGGGCATTGAAGTTGATATCGATGTGGAGCACGGAGGGAAAAGAAGCCGCCTGACCCCCGTCTCTCCAGAGAGTTCCA GCACAGAGGAGAAGAGCAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACGCAGTCTC TGGCGGAGCAGATGAGGAAGATCGCCTTGGAGTCCGAGGGGCGCCCTGAGGAACAGATGGAGTCGGATAACTGTTCAGGAGGAGATGATG ACTGGACCCATCTGTCTTCAAAAGAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTC TGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCACATCTCCCGCCAGAGGCTGACCCGCGGCTGATTGAGT CCCTCTCCCAGATGCTGTCCATGGGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAACTATGACATCGGAGCGG CTCTGGACACCATCCAGTATTCAAAGCATCCCCCGCCGTTGTGACCACTTTTGCCCACCTCTTCTGCGTGCCCCTCTTCTGTCTCATAGT TGTGTTAAGCTTGCGTAGAATTGCAGGTCTCTGTACGGGCCAGTTTCTCTGCCTTCTTCCAGGATCAGGGGTTAGGGTGCAAGAAGCCAT TTAGGGCAGCAAAACAAGTGACATGAAGGGAGGGTCCCTGTGTGTGTGTGTGCTGATGTTTCCTGGGTGCCCTGGCTCCTTGCAGCAGGG CTGGGCCTGCGAGACCCAAGGCTCACTGCAGCGCGCTCCTGACCCCTCCCTGCAGGGGCTACGTTAGCAGCCCAGCACATAGCTTGCCTA ATGGCTTTCACTTTCTCTTTTGTTTTAAATGACTCATAGGTCCCTGACATTTAGTTGATTATTTTCTGCTACAGACCTGGTACACTCTGA TTTTAGATAAAGTAAGCCTAGGTGTTGTCAGCAGGCAGGCTGGGGAGGCCAGTGTTGTGGGCTTCCTGCTGGGACTGAGAAGGCTCACGA AGGGCATCCGCAATGTTGGTTTCACTGAGAGCTGCCTCCTGGTCTCTTCACCACTGTAGTTCTCTCATTTCCAAACCATCAGCTGCTTTT AAAATAAGATCTCTTTGTAGCCATCCTGTTAAATTTGTAAACAATCTAATTAAATGGCATCAGCACTTTAACCAATGACGTTTGCATAGA GAGAAATGATTGACAGTAAGTTTATTGTTAATGGTTCTTACAGAGTATCTTTAAAAGTGCCTTAGGGGAACCCTGTCCCTCCTAACAAGT GTATCTCGATTAATAACCTGCCAGTCCCAGATCACACATCATCATCGAAGTCTTCCCCAGTTATAAAGAGGTCACATAGTCGTGTGGGTC GAGGATTCTGTGCCTCCAGGACCAGGGGCCCACCCTCTGCCCAGGGAGTCCTTGCGTCCCATGAGGTCTTCCCGCAAGGCCTCTCAGACC CAGATGTGACGGGGTGTGTGGCCCGAGGAAGCTGGACAGCGGCAGTGGGCCTGCTGAGGCCTTCTCTTGAGGCCTGTGCTCTGGGGGTCC CTTGCTTAGCCTGTGCTGGACCAGCTGGCCTGGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGTGAACTTTTTCTAGGTG GCAGGACAAATTGCGCCCATTTAGAGGATGTGGCTGTAACCTGCTGGATGGGACTCCATAGCTCCTTCCCAGGACCCCTCAGCTCCCCGG CACTGCAGTCTGCAGAGTTCTCCTGGAGGCAGGGGCTGCTGCCTTGTTTCACCTTCCATGTCAGGCCAGCCTGTCCCTGAAAGAGAAGAT GGCCATGCCCTCCATGTGTAAGAACAATGCCAGGGCCCAGGAGGACCGCCTGCCCTGCCTGGGCCTTGGCTGGGCCTCTGGTTCTGACAC >68278_68278_3_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000395741_SQSTM1_chr5_179250921_ENST00000376929_length(amino acids)=654AA_BP= MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESRQDCVEQLLKNMFDGDRTESCLVSGT QVLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTP SINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQK CCLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDY QIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDEDIWEDSDTRCAARVMARPSG -------------------------------------------------------------- >68278_68278_4_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000395744_SQSTM1_chr5_179250921_ENST00000376929_length(transcript)=4755nt_BP=2315nt CCATTTTGGAGCGATCGGAGTGCCGCCCGCGGCCCCGAGTCGGTCTCGAGCCGCCGGCCGGCCGTGCCGGTGTCCGTAGGCGCTGCGCCC TCGGCCGGGCCCATGTGTGTGCGGCCCGCCCGAGGCCGCCCGGGCTTTGCCTCCACCAGCGCCCTGGCCTCCGCTCGGGCCTCCACACGG GCCTCCGAAGAGCTGCCGCGACGCCCGGCCCGCAGGGCAGGTAAAGAGATTATAAATCTTCCACTGAATGAAAAAAATTTTCTTAAAGCT GCATATACTCCAAGAAAAAAACCACAAATGTTTTTCTGTTTTGCCTGAATACATGATTTAAACAAGAGATTTCCACAGAAGCTCTGCGGC CGTCACGATGTTCTGGAAGTTTGACTTGAACACCACGTCCCATGTTGACAAGCTGCTGGACAAGGAGCATGTGACGCTGCAGGAGTTAAT GGATGAAGATGACATCTTGCAGGAGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGCATGGAGGAGCTGGT GAGCCTCATCACACAGGATCCGCCCCTGGACATGGAGGAGAAGGTCCGCTTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGA TGTGCCGCAGATCAGCGACCGCCTCGGTGGGGACGAGAGCCTGCTGAGCCTCCTGTACGACTTCTTGGACCATGAGCCGCCTCTCAATCC TCTGCTCGCCAGTTTTTTCAGCAAGACCATTGGCAATCTCATTGCAAGAAAAACCGAACAGGTGATTACGTTTTTGAAGAAGAAGGACAA GTTCATCAGCCTGGTGTTGAAGCACATCGGCACCTCAGCGCTTATGGACCTGCTGCTGCGCCTGGTCAGCTGTGTGGAGCCAGCCGGGCT CCGGCAGGACGTCCTGCACTGGCTGAATGAAGAGAAGGTCATCCAGAGGCTTGTGGAGTTGATCCACCCGAGCCAGGATGAAGATAGGCA GTCAAATGCTTCTCAGACTCTCTGTGACATAGTTAGGCTGGGCAGAGACCAGGGCAGTCAGCTGCAAGAGGCTCTGGAGCCAGACCCGCT CCTCACAGCGCTGGAGTCGCAGGACTGTGTGGAGCAGCTTCTGAAGAACATGTTTGATGGAGACCGGACGGAGAGCTGCCTCGTCAGTGG GACTCAGGTGTTACTCACCTTGCTGGAAACCAGGCGGGTTGGGACAGAGGGCTTGGTGGACTCCTTTTCTCAGGGACTGGAAAGGTCATA CGCTGTCAGCAGCAGCGTACTACACGGCATCGAGCCTCGGCTGAAGGACTTCCACCAGCTCCTGCTCAACCCGCCCAAGAAGAAAGCGAT CCTGACCACCATTGGTGTGCTGGAGGAGCCCCTGGGGAATGCCCGTCTGCATGGCGCCCGCCTCATGGCAGCACTGCTGCACACAAACAC ACCCAGCATCAACCAGGAGCTCTGCCGGCTCAACACGATGGACTTACTGCTGGACTTGTTCTTTAAGTACACCTGGAATAACTTTTTGCA CTTCCAAGTGGAACTATGCATAGCCGCTATTCTCTCCCACGCTGCCCGTGAGGAGAGGACAGAAGCCAGCGGATCCGAGAGCAGGGTGGA GCCTCCGCATGAGAACGGGAACCGGAGCCTGGAGACTCCCCAGCCGGCCGCCAGCCTCCCTGACAACACAATGGTGACCCACCTGTTCCA GAAGTGCTGCCTGGTGCAGAGGATCCTGGAGGCCTGGGAAGCCAACGACCACACGCAGGCAGCGGGTGGCATGAGACGTGGGAACATGGG CCACCTCACACGGATCGCCAACGCGGTGGTGCAGAACCTGGAGCGGGGCCCTGTGCAGACGCACATCAGCGAGGTCATCCGAGGGCTCCC TGCGGACTGCCGTGGCCGCTGGGAGAGCTTCGTGGAGGAGACGCTGACGGAGACGAACCGCAGGAACACTGTGGACCTGGCCTTCTCTGA CTACCAGATCCAGCAGATGACAGCCAACTTCGTGGATCAGTTTGGCTTCAATGATGAGGAGTTTGCCGACCAGGACGACAACATCAATGC CCCGTTTGACAGGATCGCAGAGATCAACTTCAACATCGACGCTGACGAGGACAGTCCCAGCGCAGCTCTGTTTGAGGCCTGCTGCAGTGA CCGCATCCAGCCCTTTGATGATGATGAGGACGAGGACATCTGGGAGGACAGTGACACTCGCTGTGCTGCCCGGGTGATGGCCAGACCCAG TGGGGCAGGTGCCCCACCGGCCCCCGGGAAGAAGGAAGCGCCCCCTGTGGAGGGTGACTCAGAAGGCACCCCAATGTGATCTGCGATGGC TGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCAC CGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACAC GGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCC ACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCT CTGGGCATTGAAGTTGATATCGATGTGGAGCACGGAGGGAAAAGAAGCCGCCTGACCCCCGTCTCTCCAGAGAGTTCCAGCACAGAGGAG AAGAGCAGCTCACAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACGCAGTCTCTGGCGGAGCAG ATGAGGAAGATCGCCTTGGAGTCCGAGGGGCGCCCTGAGGAACAGATGGAGTCGGATAACTGTTCAGGAGGAGATGATGACTGGACCCAT CTGTCTTCAAAAGAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCAAGCTCTCTGGACCCCTCC CAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCACATCTCCCGCCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAG ATGCTGTCCATGGGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAACTATGACATCGGAGCGGCTCTGGACACC ATCCAGTATTCAAAGCATCCCCCGCCGTTGTGACCACTTTTGCCCACCTCTTCTGCGTGCCCCTCTTCTGTCTCATAGTTGTGTTAAGCT TGCGTAGAATTGCAGGTCTCTGTACGGGCCAGTTTCTCTGCCTTCTTCCAGGATCAGGGGTTAGGGTGCAAGAAGCCATTTAGGGCAGCA AAACAAGTGACATGAAGGGAGGGTCCCTGTGTGTGTGTGTGCTGATGTTTCCTGGGTGCCCTGGCTCCTTGCAGCAGGGCTGGGCCTGCG AGACCCAAGGCTCACTGCAGCGCGCTCCTGACCCCTCCCTGCAGGGGCTACGTTAGCAGCCCAGCACATAGCTTGCCTAATGGCTTTCAC TTTCTCTTTTGTTTTAAATGACTCATAGGTCCCTGACATTTAGTTGATTATTTTCTGCTACAGACCTGGTACACTCTGATTTTAGATAAA GTAAGCCTAGGTGTTGTCAGCAGGCAGGCTGGGGAGGCCAGTGTTGTGGGCTTCCTGCTGGGACTGAGAAGGCTCACGAAGGGCATCCGC AATGTTGGTTTCACTGAGAGCTGCCTCCTGGTCTCTTCACCACTGTAGTTCTCTCATTTCCAAACCATCAGCTGCTTTTAAAATAAGATC TCTTTGTAGCCATCCTGTTAAATTTGTAAACAATCTAATTAAATGGCATCAGCACTTTAACCAATGACGTTTGCATAGAGAGAAATGATT GACAGTAAGTTTATTGTTAATGGTTCTTACAGAGTATCTTTAAAAGTGCCTTAGGGGAACCCTGTCCCTCCTAACAAGTGTATCTCGATT AATAACCTGCCAGTCCCAGATCACACATCATCATCGAAGTCTTCCCCAGTTATAAAGAGGTCACATAGTCGTGTGGGTCGAGGATTCTGT GCCTCCAGGACCAGGGGCCCACCCTCTGCCCAGGGAGTCCTTGCGTCCCATGAGGTCTTCCCGCAAGGCCTCTCAGACCCAGATGTGACG GGGTGTGTGGCCCGAGGAAGCTGGACAGCGGCAGTGGGCCTGCTGAGGCCTTCTCTTGAGGCCTGTGCTCTGGGGGTCCCTTGCTTAGCC TGTGCTGGACCAGCTGGCCTGGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGTGAACTTTTTCTAGGTGGCAGGACAAAT TGCGCCCATTTAGAGGATGTGGCTGTAACCTGCTGGATGGGACTCCATAGCTCCTTCCCAGGACCCCTCAGCTCCCCGGCACTGCAGTCT GCAGAGTTCTCCTGGAGGCAGGGGCTGCTGCCTTGTTTCACCTTCCATGTCAGGCCAGCCTGTCCCTGAAAGAGAAGATGGCCATGCCCT CCATGTGTAAGAACAATGCCAGGGCCCAGGAGGACCGCCTGCCCTGCCTGGGCCTTGGCTGGGCCTCTGGTTCTGACACTTTCTGCTGGA >68278_68278_4_PPP6R2-SQSTM1_PPP6R2_chr22_50877126_ENST00000395744_SQSTM1_chr5_179250921_ENST00000376929_length(amino acids)=653AA_BP= MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVP QISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGTQ VLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPS INQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQKC CLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDYQ IQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDEDIWEDSDTRCAARVMARPSGA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PPP6R2-SQSTM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 122_224 | 0 | 357.0 | GABRR3 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 122_224 | 0 | 357.0 | GABRR3 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 122_224 | 0 | 441.0 | GABRR3 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 122_224 | 0 | 357.0 | GABRR3 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 347_352 | 0 | 357.0 | KEAP1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 347_352 | 0 | 357.0 | KEAP1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 347_352 | 0 | 441.0 | KEAP1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 347_352 | 0 | 357.0 | KEAP1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 2_50 | 0 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 2_50 | 0 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 2_50 | 0 | 441.0 | LCK | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 2_50 | 0 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 269_440 | 0 | 357.0 | NTRK1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 269_440 | 0 | 357.0 | NTRK1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 269_440 | 0 | 441.0 | NTRK1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 269_440 | 0 | 357.0 | NTRK1 | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 50_80 | 0 | 357.0 | PAWR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 50_80 | 0 | 357.0 | PAWR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 50_80 | 0 | 441.0 | PAWR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 50_80 | 0 | 357.0 | PAWR | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000360718 | 0 | 7 | 43_107 | 0 | 357.0 | PRKCZ and dimerization | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000376929 | 0 | 9 | 43_107 | 0 | 357.0 | PRKCZ and dimerization | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000389805 | 0 | 8 | 43_107 | 0 | 441.0 | PRKCZ and dimerization | |
| Tgene | SQSTM1 | chr22:50877126 | chr5:179250921 | ENST00000402874 | 0 | 8 | 43_107 | 0 | 357.0 | PRKCZ and dimerization |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PPP6R2-SQSTM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PPP6R2-SQSTM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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