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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP6R3-ACER3 (FusionGDB2 ID:68285)

Fusion Gene Summary for PPP6R3-ACER3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R3-ACER3
Fusion gene ID: 68285
HgeneTgene
Gene symbol

PPP6R3

ACER3

Gene ID

55291

55331

Gene nameprotein phosphatase 6 regulatory subunit 3alkaline ceramidase 3
SynonymsC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3APHC|PHCA|PLDECO
Cytomap

11q13.2

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPLalkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline
Modification date2020031320200320
UniProtAcc.

Q9NUN7

Ensembl transtripts involved in fusion geneENST00000530427, ENST00000265636, 
ENST00000265637, ENST00000393799, 
ENST00000393800, ENST00000393801, 
ENST00000524845, ENST00000524904, 
ENST00000527403, ENST00000529710, 
ENST00000534534, 		ENST00000532485, 
ENST00000530182, ENST00000526597, 
ENST00000533873, ENST00000538157, 
ENST00000544113, 
Fusion gene scores* DoF score34 X 21 X 15=1071013 X 10 X 5=650
# samples 4315
** MAII scorelog2(43/10710*10)=-4.63847801004816
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/650*10)=-2.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP6R3 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP6R3(68305359)-ACER3(76687333), # samples:3
Anticipated loss of major functional domain due to fusion event.PPP6R3-ACER3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP6R3-ACER3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPP6R3-ACER3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191

TgeneACER3

GO:0043067

regulation of programmed cell death

20068046

TgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

TgeneACER3

GO:0046514

ceramide catabolic process

30575723

TgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check buttonFusion gene breakpoints across PPP6R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACER3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-YG-AA3P-06APPP6R3chr11

68287119

+ACER3chr11

76687333

+
ChimerDB4SKCMTCGA-YG-AA3P-06APPP6R3chr11

68305359

-ACER3chr11

76687333

+
ChimerDB4SKCMTCGA-YG-AA3P-06APPP6R3chr11

68305359

+ACER3chr11

76687333

+


Top

Fusion Gene ORF analysis for PPP6R3-ACER3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000530427ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
3UTR-3UTRENST00000530427ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
3UTR-5UTRENST00000530427ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
3UTR-5UTRENST00000530427ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
3UTR-5UTRENST00000530427ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
3UTR-intronENST00000530427ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5CDS-3UTRENST00000265636ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000265637ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000393799ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000393800ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000393801ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000524845ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000524904ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000527403ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-3UTRENST00000529710ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265636ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265636ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265636ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265637ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265637ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000265637ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393799ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393799ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393799ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393800ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393800ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393800ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393801ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393801ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000393801ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524845ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524845ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524845ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524904ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524904ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000524904ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000527403ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000527403ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000527403ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000529710ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000529710ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-5UTRENST00000529710ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000265636ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000265637ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000393799ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000393800ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000393801ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000524845ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000524904ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000527403ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5CDS-intronENST00000529710ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
5UTR-3CDSENST00000265636ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000393799ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000393800ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000393801ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000524845ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000524904ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000527403ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000529710ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3CDSENST00000534534ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000265636ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000393799ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000393800ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000393801ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000524845ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000524904ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000527403ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000529710ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-3UTRENST00000534534ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000265636ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000265636ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000265636ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393799ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393799ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393799ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393800ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393800ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393800ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393801ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393801ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000393801ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524845ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524845ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524845ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524904ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524904ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000524904ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000527403ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000527403ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000527403ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000529710ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000529710ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000529710ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000534534ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000534534ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-5UTRENST00000534534ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000265636ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000393799ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000393800ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000393801ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000524845ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000524904ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000527403ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000529710ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
5UTR-intronENST00000534534ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
Frame-shiftENST00000265636ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000265637ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000393799ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000393800ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000393801ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000524845ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000524904ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000527403ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
Frame-shiftENST00000529710ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-3CDSENST00000265637ENST00000532485PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-3CDSENST00000530427ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-3CDSENST00000534534ENST00000532485PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-3UTRENST00000265637ENST00000530182PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-3UTRENST00000530427ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-3UTRENST00000534534ENST00000530182PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000265637ENST00000526597PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-5UTRENST00000265637ENST00000533873PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-5UTRENST00000265637ENST00000538157PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-5UTRENST00000530427ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000530427ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000530427ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000534534ENST00000526597PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000534534ENST00000533873PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-5UTRENST00000534534ENST00000538157PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-intronENST00000265637ENST00000544113PPP6R3chr11

68287119

+ACER3chr11

76687333

+
intron-intronENST00000530427ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+
intron-intronENST00000534534ENST00000544113PPP6R3chr11

68305359

+ACER3chr11

76687333

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for PPP6R3-ACER3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP6R3chr1168305359+ACER3chr1176687332+0.0063965430.9936034
PPP6R3chr1168287119+ACER3chr1176687332+0.0005543860.9994456
PPP6R3chr1168305359+ACER3chr1176687332+0.0063965430.9936034
PPP6R3chr1168287119+ACER3chr1176687332+0.0005543860.9994456

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP6R3-ACER3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:68305359/:76687333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACER3

Q9NUN7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q9D099, ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20068046, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:26792856, ECO:0000269|PubMed:30575723, ECO:0000303|PubMed:20068046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP6R3-ACER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP6R3-ACER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP6R3-ACER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP6R3-ACER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource