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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP6R3-NCOA1 (FusionGDB2 ID:68310)

Fusion Gene Summary for PPP6R3-NCOA1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R3-NCOA1
Fusion gene ID: 68310
HgeneTgene
Gene symbol

PPP6R3

NCOA1

Gene ID

55291

8648

Gene nameprotein phosphatase 6 regulatory subunit 3nuclear receptor coactivator 1
SynonymsC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74
Cytomap

11q13.2

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPLnuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1
Modification date2020031320200313
UniProtAcc.

Q15788

Ensembl transtripts involved in fusion geneENST00000530427, ENST00000265636, 
ENST00000393799, ENST00000393800, 
ENST00000393801, ENST00000524845, 
ENST00000524904, ENST00000527403, 
ENST00000529710, ENST00000534534, 
ENST00000265637, 		ENST00000469850, 
ENST00000288599, ENST00000348332, 
ENST00000405141, ENST00000406961, 
ENST00000407230, ENST00000538539, 
ENST00000395856, 
Fusion gene scores* DoF score34 X 21 X 15=1071011 X 13 X 7=1001
# samples 4313
** MAII scorelog2(43/10710*10)=-4.63847801004816
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP6R3 [Title/Abstract] AND NCOA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP6R3(68287119)-NCOA1(24807345), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191

TgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

TgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

TgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

TgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check buttonFusion gene breakpoints across PPP6R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NCOA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01APPP6R3chr11

68287119

+NCOA1chr2

24807345

+


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Fusion Gene ORF analysis for PPP6R3-NCOA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000530427ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-5UTRENST00000530427ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
3UTR-intronENST00000530427ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000265636ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000393799ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000393800ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000393801ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000524845ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000524904ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000527403ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000529710ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-3UTRENST00000534534ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000265636ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393799ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393800ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000393801ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524845ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000524904ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000527403ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000529710ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-5UTRENST00000534534ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000265636ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000393799ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000393800ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000393801ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000524845ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000524904ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000527403ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000529710ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
5UTR-intronENST00000534534ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-3UTRENST00000265637ENST00000469850PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000288599PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000348332PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000405141PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000406961PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000407230PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-5UTRENST00000265637ENST00000538539PPP6R3chr11

68287119

+NCOA1chr2

24807345

+
intron-intronENST00000265637ENST00000395856PPP6R3chr11

68287119

+NCOA1chr2

24807345

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP6R3-NCOA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP6R3chr1168287119+NCOA1chr224807345+7.62E-060.9999924
PPP6R3chr1168287119+NCOA1chr224807345+7.62E-060.9999924

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP6R3-NCOA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:68287119/:24807345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCOA1

Q15788

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP6R3-NCOA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP6R3-NCOA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP6R3-NCOA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP6R3-NCOA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource