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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPTC7-ALS2CR12 (FusionGDB2 ID:68335)

Fusion Gene Summary for PPTC7-ALS2CR12

check button Fusion gene summary
Fusion gene informationFusion gene name: PPTC7-ALS2CR12
Fusion gene ID: 68335
HgeneTgene
Gene symbol

PPTC7

ALS2CR12

Gene ID

160760

130540

Gene nameprotein phosphatase targeting COQ7flagellum associated containing coiled-coil domains 1
SynonymsTA-PP2C|TAPP2CALS2CR12
Cytomap

12q24.11

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase PTC7 homologPTC7 protein phosphatase homologflagellum-associated coiled-coil domain-containing protein 1ALS2 chromosome region 12amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 proteinamyotrophic late
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000354300, ENST00000448967, 
ENST00000286190, ENST00000392257, 
ENST00000405148, ENST00000439709, 
Fusion gene scores* DoF score7 X 6 X 6=2526 X 4 X 4=96
# samples 108
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPTC7 [Title/Abstract] AND ALS2CR12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPTC7(111020614)-ALS2CR12(202195245), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPTC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALS2CR12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07U-01APPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
ChimerDB4BRCATCGA-A8-A07U-01APPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
ChimerDB4BRCATCGA-A8-A07UPPTC7chr12

111020613

-ALS2CR12chr2

202173973

-


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Fusion Gene ORF analysis for PPTC7-ALS2CR12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354300ENST00000448967PPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
5CDS-5UTRENST00000354300ENST00000448967PPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
5CDS-5UTRENST00000354300ENST00000448967PPTC7chr12

111020613

-ALS2CR12chr2

202173973

-
Frame-shiftENST00000354300ENST00000286190PPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
Frame-shiftENST00000354300ENST00000392257PPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
Frame-shiftENST00000354300ENST00000405148PPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
Frame-shiftENST00000354300ENST00000439709PPTC7chr12

111020614

-ALS2CR12chr2

202195245

-
In-frameENST00000354300ENST00000286190PPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000286190PPTC7chr12

111020613

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000392257PPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000392257PPTC7chr12

111020613

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000405148PPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000405148PPTC7chr12

111020613

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000439709PPTC7chr12

111020614

-ALS2CR12chr2

202173973

-
In-frameENST00000354300ENST00000439709PPTC7chr12

111020613

-ALS2CR12chr2

202173973

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354300PPTC7chr12111020613-ENST00000286190ALS2CR12chr2202173973-15595125301174214
ENST00000354300PPTC7chr12111020613-ENST00000405148ALS2CR12chr2202173973-14065125301174214
ENST00000354300PPTC7chr12111020613-ENST00000392257ALS2CR12chr2202173973-13365125301105191
ENST00000354300PPTC7chr12111020613-ENST00000439709ALS2CR12chr2202173973-13315125301105191
ENST00000354300PPTC7chr12111020614-ENST00000286190ALS2CR12chr2202173973-15595125301174214
ENST00000354300PPTC7chr12111020614-ENST00000405148ALS2CR12chr2202173973-14065125301174214
ENST00000354300PPTC7chr12111020614-ENST00000392257ALS2CR12chr2202173973-13365125301105191
ENST00000354300PPTC7chr12111020614-ENST00000439709ALS2CR12chr2202173973-13315125301105191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354300ENST00000286190PPTC7chr12111020613-ALS2CR12chr2202173973-0.0021765670.9978235
ENST00000354300ENST00000405148PPTC7chr12111020613-ALS2CR12chr2202173973-0.0027642580.9972357
ENST00000354300ENST00000392257PPTC7chr12111020613-ALS2CR12chr2202173973-0.0021621430.99783784
ENST00000354300ENST00000439709PPTC7chr12111020613-ALS2CR12chr2202173973-0.0022010920.99779886
ENST00000354300ENST00000286190PPTC7chr12111020614-ALS2CR12chr2202173973-0.0021765670.9978235
ENST00000354300ENST00000405148PPTC7chr12111020614-ALS2CR12chr2202173973-0.0027642580.9972357
ENST00000354300ENST00000392257PPTC7chr12111020614-ALS2CR12chr2202173973-0.0021621430.99783784
ENST00000354300ENST00000439709PPTC7chr12111020614-ALS2CR12chr2202173973-0.0022010920.99779886

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Fusion Genomic Features for PPTC7-ALS2CR12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPTC7-ALS2CR12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:111020614/chr2:202195245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000286190714283_315225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000286190714387_414225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000392257815283_315225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000392257815387_414225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000405148815283_315225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000405148815387_414225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000439709815283_315225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000439709815387_414225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000286190714283_315225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000286190714387_414225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000392257815283_315225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000392257815387_414225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000405148815283_315225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000405148815387_414225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000439709815283_315225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000439709815387_414225423.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPTC7chr12:111020613chr2:202173973ENST00000354300-1617_8774305.0Compositional biasGly-rich
HgenePPTC7chr12:111020614chr2:202173973ENST00000354300-1617_8774305.0Compositional biasGly-rich
HgenePPTC7chr12:111020613chr2:202173973ENST00000354300-1669_29974305.0DomainPPM-type phosphatase
HgenePPTC7chr12:111020614chr2:202173973ENST00000354300-1669_29974305.0DomainPPM-type phosphatase
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000286190714122_226225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000392257815122_226225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000405148815122_226225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020613chr2:202173973ENST00000439709815122_226225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000286190714122_226225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000392257815122_226225423.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000405148815122_226225446.0Coiled coilOntology_term=ECO:0000255
TgeneALS2CR12chr12:111020614chr2:202173973ENST00000439709815122_226225423.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for PPTC7-ALS2CR12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68335_68335_1_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000286190_length(transcript)=1559nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTGCCCTGGAGAAGAGACCAAATAAATAGAC
ATTGGCATGATGTCCTGCAACAGCTTCTTCTTATGCAGGTCATGCAGGAAGAATTGCATGCACAAGCCCTTATCCTAGAGTCACTGAACA
CAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGCTTCAAACCAAGTTTGCTGAAA
CTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAATTTCTAAGAATGAAGAAATTT
GTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATGGTAGCAAGAAAGGACAAGAAT
CATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTCCTGGGAGGGTTTTCTTGAGAA
AATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGCATCTGAATTTCACAGCTTATC
ACGGACTCTTCACTGAAAAATGATGCTCTCCATACTGGGAGCTGAGCTTTCTCTGAGTTTTGTACTATTTTTCTTCTACCTTGACGTATT
TCGTTAGAAAGAAACTGATTTGAAGGCCTTCTTCATATTGAACTTTTACTATATTTGGGAGGTGTACCTTTGTCCCCTGGGGCATTTAGG

>68335_68335_1_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000286190_length(amino acids)=214AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQ
INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN

--------------------------------------------------------------
>68335_68335_2_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000392257_length(transcript)=1336nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTCATGCAGGAAGAATTGCATGCACAAGCCC
TTATCCTAGAGTCACTGAACACAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGC
TTCAAACCAAGTTTGCTGAAACTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAA
TTTCTAAGAATGAAGAAATTTGTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATG
GTAGCAAGAAAGGACAAGAATCATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTC
CTGGGAGGGTTTTCTTGAGAAAATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGC

>68335_68335_2_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000392257_length(amino acids)=191AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELH
AQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDT

--------------------------------------------------------------
>68335_68335_3_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000405148_length(transcript)=1406nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTGCCCTGGAGAAGAGACCAAATAAATAGAC
ATTGGCATGATGTCCTGCAACAGCTTCTTCTTATGCAGGTCATGCAGGAAGAATTGCATGCACAAGCCCTTATCCTAGAGTCACTGAACA
CAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGCTTCAAACCAAGTTTGCTGAAA
CTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAATTTCTAAGAATGAAGAAATTT
GTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATGGTAGCAAGAAAGGACAAGAAT
CATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTCCTGGGAGGGTTTTCTTGAGAA
AATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGCATCTGAATTTCACAGCTTATC

>68335_68335_3_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000405148_length(amino acids)=214AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQ
INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN

--------------------------------------------------------------
>68335_68335_4_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000439709_length(transcript)=1331nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTCATGCAGGAAGAATTGCATGCACAAGCCC
TTATCCTAGAGTCACTGAACACAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGC
TTCAAACCAAGTTTGCTGAAACTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAA
TTTCTAAGAATGAAGAAATTTGTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATG
GTAGCAAGAAAGGACAAGAATCATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTC
CTGGGAGGGTTTTCTTGAGAAAATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGC

>68335_68335_4_PPTC7-ALS2CR12_PPTC7_chr12_111020613_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000439709_length(amino acids)=191AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELH
AQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDT

--------------------------------------------------------------
>68335_68335_5_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000286190_length(transcript)=1559nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTGCCCTGGAGAAGAGACCAAATAAATAGAC
ATTGGCATGATGTCCTGCAACAGCTTCTTCTTATGCAGGTCATGCAGGAAGAATTGCATGCACAAGCCCTTATCCTAGAGTCACTGAACA
CAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGCTTCAAACCAAGTTTGCTGAAA
CTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAATTTCTAAGAATGAAGAAATTT
GTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATGGTAGCAAGAAAGGACAAGAAT
CATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTCCTGGGAGGGTTTTCTTGAGAA
AATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGCATCTGAATTTCACAGCTTATC
ACGGACTCTTCACTGAAAAATGATGCTCTCCATACTGGGAGCTGAGCTTTCTCTGAGTTTTGTACTATTTTTCTTCTACCTTGACGTATT
TCGTTAGAAAGAAACTGATTTGAAGGCCTTCTTCATATTGAACTTTTACTATATTTGGGAGGTGTACCTTTGTCCCCTGGGGCATTTAGG

>68335_68335_5_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000286190_length(amino acids)=214AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQ
INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN

--------------------------------------------------------------
>68335_68335_6_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000392257_length(transcript)=1336nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTCATGCAGGAAGAATTGCATGCACAAGCCC
TTATCCTAGAGTCACTGAACACAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGC
TTCAAACCAAGTTTGCTGAAACTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAA
TTTCTAAGAATGAAGAAATTTGTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATG
GTAGCAAGAAAGGACAAGAATCATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTC
CTGGGAGGGTTTTCTTGAGAAAATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGC

>68335_68335_6_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000392257_length(amino acids)=191AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELH
AQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDT

--------------------------------------------------------------
>68335_68335_7_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000405148_length(transcript)=1406nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTGCCCTGGAGAAGAGACCAAATAAATAGAC
ATTGGCATGATGTCCTGCAACAGCTTCTTCTTATGCAGGTCATGCAGGAAGAATTGCATGCACAAGCCCTTATCCTAGAGTCACTGAACA
CAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGCTTCAAACCAAGTTTGCTGAAA
CTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAATTTCTAAGAATGAAGAAATTT
GTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATGGTAGCAAGAAAGGACAAGAAT
CATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTCCTGGGAGGGTTTTCTTGAGAA
AATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGCATCTGAATTTCACAGCTTATC

>68335_68335_7_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000405148_length(amino acids)=214AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQ
INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN

--------------------------------------------------------------
>68335_68335_8_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000439709_length(transcript)=1331nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGACAGTATTTATGATGAAATGGAAGAGA
AGTGGTCAAAACAGAAGGCGAAATGGAAGAAGGATGAGAAGTTCGAGCGAGAAAATATCCTGCTACAGCAAAAAAAAAAGATGACCAAAA
AATTCGAAATGGAGTCAGGAGAAGAAGATAAGAAAATAAATGAATCCTGCAGTGCTGTCTTTGAGAACTTCATTCAAGAGAAGGAGGAGC
TCTTGAAACAACATCAAAGTGACACCTTGCAATTAGAAGAGCTGAGAAAAACCAAAGAGGTCATGCAGGAAGAATTGCATGCACAAGCCC
TTATCCTAGAGTCACTGAACACAAACCTCTACTATACCCAGTTGGAACTCCAGAAAGAGAAAGCTATAGTGGGAAATCTGGAGAAAATGC
TTCAAACCAAGTTTGCTGAAACTGAAGAAAAGTATAAGCACACCATACAGATCCTGACGGAAGAGAACATTCATCTGAAGCAAAAGATAA
TTTCTAAGAATGAAGAAATTTGTGAAGGATGTTCTGGGAGATTGGCCTCTATTACTGTTTCTAAGGATGATTCTGACACTGTGCAAGATG
GTAGCAAGAAAGGACAAGAATCATAAACAAAAAGTTGCTCTGCATTGTTGAAGATGGTTGGCACACCATTTCTGTAGGCCCAGGAAACTC
CTGGGAGGGTTTTCTTGAGAAAATGCATATAATGAGTTTAGTTCTTGGGTTGCTCTGACTCTCTGAATGTCTGAAAATGTTTGAATTCGC

>68335_68335_8_PPTC7-ALS2CR12_PPTC7_chr12_111020614_ENST00000354300_ALS2CR12_chr2_202173973_ENST00000439709_length(amino acids)=191AA_BP=
MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELH
AQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPTC7-ALS2CR12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPTC7-ALS2CR12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPTC7-ALS2CR12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource