Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPTC7-IGF1 (FusionGDB2 ID:68339)

Fusion Gene Summary for PPTC7-IGF1

Fusion gene summary

Fusion gene information	Fusion gene name: PPTC7-IGF1
	Fusion gene ID: 68339
		Hgene	Tgene
	Gene symbol	PPTC7	IGF1
	Gene ID	160760	3479
	Gene name	protein phosphatase targeting COQ7	insulin like growth factor 1
	Synonyms	TA-PP2C\|TAPP2C	IGF\|IGF-I\|IGFI\|MGF
	Cytomap	12q24.11	12q23.2
	Type of gene	protein-coding	protein-coding
	Description	protein phosphatase PTC7 homologPTC7 protein phosphatase homolog	insulin-like growth factor Iinsulin-like growth factor 1 (somatomedin C)insulin-like growth factor IBmechano growth factorsomatomedin-C
	Modification date	20200313	20200322
	UniProtAcc	.	P08069
	Ensembl transtripts involved in fusion gene	ENST00000354300,	ENST00000307046, ENST00000392904, ENST00000424202, ENST00000481539, ENST00000337514, ENST00000456098,
Fusion gene scores	* DoF score	7 X 6 X 6=252	6 X 5 X 5=150
	# samples	10	6
	** MAII score	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPTC7 [Title/Abstract] AND IGF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPTC7(111020614)-IGF1(102869577), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	IGF1	GO:0001775	cell activation	22797923
Tgene	IGF1	GO:0008284	positive regulation of cell proliferation	7688386\|9722506\|12746903
Tgene	IGF1	GO:0009408	response to heat	11404306
Tgene	IGF1	GO:0010613	positive regulation of cardiac muscle hypertrophy	19654000
Tgene	IGF1	GO:0010629	negative regulation of gene expression	29167509
Tgene	IGF1	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	7688386
Tgene	IGF1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	17531227
Tgene	IGF1	GO:0014904	myotube cell development	17531227
Tgene	IGF1	GO:0014911	positive regulation of smooth muscle cell migration	10766744
Tgene	IGF1	GO:0030166	proteoglycan biosynthetic process	12746903
Tgene	IGF1	GO:0034392	negative regulation of smooth muscle cell apoptotic process	16942485
Tgene	IGF1	GO:0035630	bone mineralization involved in bone maturation	16433617
Tgene	IGF1	GO:0042104	positive regulation of activated T cell proliferation	15694994
Tgene	IGF1	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	9722506
Tgene	IGF1	GO:0043388	positive regulation of DNA binding	19654000
Tgene	IGF1	GO:0043410	positive regulation of MAPK cascade	19654000
Tgene	IGF1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	7688386\|10766744
Tgene	IGF1	GO:0045445	myoblast differentiation	17531227
Tgene	IGF1	GO:0045669	positive regulation of osteoblast differentiation	16433617
Tgene	IGF1	GO:0045725	positive regulation of glycogen biosynthetic process	21076856
Tgene	IGF1	GO:0045821	positive regulation of glycolytic process	7688386
Tgene	IGF1	GO:0045840	positive regulation of mitotic nuclear division	7188854\|10644978
Tgene	IGF1	GO:0045893	positive regulation of transcription, DNA-templated	9722506\|19654000
Tgene	IGF1	GO:0045944	positive regulation of transcription by RNA polymerase II	16433617
Tgene	IGF1	GO:0046326	positive regulation of glucose import	21076856
Tgene	IGF1	GO:0046579	positive regulation of Ras protein signal transduction	9722506
Tgene	IGF1	GO:0048015	phosphatidylinositol-mediated signaling	7692086
Tgene	IGF1	GO:0048146	positive regulation of fibroblast proliferation	7188854
Tgene	IGF1	GO:0048661	positive regulation of smooth muscle cell proliferation	10766744\|16942485
Tgene	IGF1	GO:0050679	positive regulation of epithelial cell proliferation	7188854
Tgene	IGF1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	7782332\|22635104
Tgene	IGF1	GO:0051450	myoblast proliferation	17531227
Tgene	IGF1	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	24117217
Tgene	IGF1	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	19654000
Tgene	IGF1	GO:2000679	positive regulation of transcription regulatory region DNA binding	15059951
Tgene	IGF1	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	16942485

Fusion gene breakpoints across PPTC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IGF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-1702-01A	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-

Top

Fusion Gene ORF analysis for PPTC7-IGF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000354300	ENST00000307046	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-
5CDS-intron	ENST00000354300	ENST00000392904	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-
5CDS-intron	ENST00000354300	ENST00000424202	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-
5CDS-intron	ENST00000354300	ENST00000481539	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-
In-frame	ENST00000354300	ENST00000337514	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-
In-frame	ENST00000354300	ENST00000456098	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000354300	PPTC7	chr12	111020614	-	ENST00000456098	IGF1	chr12	102869577	-	7600	512	528	1	176
ENST00000354300	PPTC7	chr12	111020614	-	ENST00000337514	IGF1	chr12	102869577	-	7544	512	528	1	176

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354300	ENST00000456098	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-	0.068652466	0.93134755
ENST00000354300	ENST00000337514	PPTC7	chr12	111020614	-	IGF1	chr12	102869577	-	0.024223141	0.97577685

Top

Fusion Genomic Features for PPTC7-IGF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PPTC7-IGF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:111020614/chr12:102869577)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IGF1 P08069
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000307046

111_118

196.0

Region

Note=D

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000307046

49_77

196.0

Region

Note=B

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000307046

78_89

196.0

Region

Note=C

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000307046

90_110

196.0

Region

Note=A

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000337514

111_118

154.0

Region

Note=D

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000337514

49_77

154.0

Region

Note=B

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000337514

78_89

154.0

Region

Note=C

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000337514

90_110

154.0

Region

Note=A

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000392904

111_118

159.0

Region

Note=D

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000392904

49_77

159.0

Region

Note=B

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000392904

78_89

159.0

Region

Note=C

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000392904

90_110

159.0

Region

Note=A

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000424202

111_118

138.0

Region

Note=D

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000424202

49_77

138.0

Region

Note=B

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000424202

78_89

138.0

Region

Note=C

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000424202

90_110

138.0

Region

Note=A

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000456098

111_118

159.0

Region

Note=D

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000456098

49_77

159.0

Region

Note=B

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000456098

78_89

159.0

Region

Note=C

Tgene

IGF1

chr12:111020614

chr12:102869577

ENST00000456098

90_110

159.0

Region

Note=A

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPTC7

chr12:111020614

chr12:102869577

ENST00000354300

17_87

305.0

Compositional bias

Gly-rich

Hgene

PPTC7

chr12:111020614

chr12:102869577

ENST00000354300

69_299

305.0

Domain

PPM-type phosphatase

Top

Fusion Gene Sequence for PPTC7-IGF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68339_68339_1_PPTC7-IGF1_PPTC7_chr12_111020614_ENST00000354300_IGF1_chr12_102869577_ENST00000337514_length(transcript)=7544nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGTGAAGATGCACACCATGTCCTCCTCGC
ATCTCTTCTACCTGGCGCTGTGCCTGCTCACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGATG
CTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGCTCCAGCAGTCGGAGGGCGCCTCAGACAGGCA
TCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCTG
TCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAACGCAAGTAGAGGGAGTGCAGGAAACAAGAACT
ACAGGATGTAGGAAGACCCTCCTGAGGAGTGAAGAGTGACATGCCACCGCAGGATCCTTTGCTCTGCACGAGTTACCTGTTAAACTTTGG
AACACCTACCAAAAAATAAGTTTGATAACATTTAAAAGATGGGCGTTTCCCCCAATGAAATACACAAGTAAACATTCCAACATTGTCTTT
AGGAGTGATTTGCACCTTGCAAAAATGGTCCTGGAGTTGGTAGATTGCTGTTGATCTTTTATCAATAATGTTCTATAGAAAAGAAAAAAA
AAATATATATATATATATATCTTAGTCCCTGCCTCTCAAGAGCCACAAATGCATGGGTGTTGTATAGATCCAGTTGCACTAAATTCCTCT
CTGAATCTTGGCTGCTGGAGCCATTCATTCAGCAACCTTGTCTAAGTGGTTTATGAATTGTTTCCTTATTTGCACTTCTTTCTACACAAC
TCGGGCTGTTTGTTTTACAGTGTCTGATAATCTTGTTAGTCTATACCCACCACCTCCCTTCATAACCTTTATATTTGCCGAATTTGGCCT
CCTCAAAAGCAGCAGCAAGTCGTCAAGAAGCACACCAATTCTAACCCACAAGATTCCATCTGTGGCATTTGTACCAAATATAAGTTGGAT
GCATTTTATTTTAGACACAAAGCTTTATTTTTCCACATCATGCTTACAAAAAAGAATAATGCAAATAGTTGCAACTTTGAGGCCAATCAT
TTTTAGGCATATGTTTTAAACATAGAAAGTTTCTTCAACTCAAAAGAGTTCCTTCAAATGATGAGTTAATGTGCAACCTAATTAGTAACT
TTCCTCTTTTTATTTTTTCCATATAGAGCACTATGTAAATTTAGCATATCAATTATACAGGATATATCAAACAGTATGTAAAACTCTGTT
TTTTAGTATAATGGTGCTATTTTGTAGTTTGTTATATGAAAGAGTCTGGCCAAAACGGTAATACGTGAAAGCAAAACAATAGGGGAAGCC
TGGAGCCAAAGATGACACAAGGGGAAGGGTACTGAAAACACCATCCATTTGGGAAAGAAGGCAAAGTCCCCCCAGTTATGCCTTCCAAGA
GGAACTTCAGACACAAAAGTCCACTGATGCAAATTGGACTGGCGAGTCCAGAGAGGAAACTGTGGAATGGAAAAAGCAGAAGGCTAGGAA
TTTTAGCAGTCCTGGTTTCTTTTTCTCATGGAAGAAATGAACATCTGCCAGCTGTGTCATGGACTCACCACTGTGTGACCTTGGGCAAGT
CACTTCACCTCTCTGTGCCTCAGTTTCCTCATCTGCAAAATGGGGGCAATATGTCATCTACCTACCTCAAAGGGGTGGTATAAGGTTTAA
AAAGATAAAGATTCAGATTTTTTTTACCCTGGGTTGCTGTAAGGGTGCAACATCAGGGCGCTTGAGTTGCTGAGATGCAAGGAATTCTAT
AAATAACCCATTCATAGCATAGCTAGAGATTGGTGAATTGAATGCTCCTGACATCTCAGTTCTTGTCAGTGAAGCTATCCAAATAACTGG
CCAACTAGTTGTTAAAAGCTAACAGCTCAATCTCTTAAAACACTTTTCAAAATATGTGGGAAGCATTTGATTTTCAATTTGATTTTGAAT
TCTGCATTTGGTTTTATGAATACAAAGATAAGTGAAAAGAGAGAAAGGAAAAGAAAAAGGAGAAAAACAAAGAGATTTCTACCAGTGAAA
GGGGAATTAATTACTCTTTGTTAGCACTCACTGACTCTTCTATGCAGTTACTACATATCTAGTAAAACCTCGTTTAATACTATAAATAAT
ATTCTATTCATTTTGAAAAACACAATGATTCCTTCTTTTCTAGGCAATATAAGGAAAGTGATCCAAAATTTGAAATATTAAAATAATATC
TAATAAAAAGTCACAAAGTTATCTTCTTTAACAAACTTTACTCTTATTCTTAGCTGTATATACATTTTTTTAAAAGTTTGTTAAAATATG
CTTGACTAGAGTTTCCAGTTGAAAGGCAAAAACTTCCATCACAACAAGAAATTTCCCATGCCTGCTCAGAAGGGTAGCCCCTAGCTCTCT
GTGAATGTGTTTTATCCATTCAACTGAAAATTGGTATCAAGAAAGTCCACTGGTTAGTGTACTAGTCCATCATAGCCTAGAAAATGATCC
CTATCTGCAGATCAAGATTTTCTCATTAGAACAATGAATTATCCAGCATTCAGATCTTTCTAGTCACCTTAGAACTTTTTGGTTAAAAGT
ACCCAGGCTTGATTATTTCATGCAAATTCTATATTTTACATTCTTGGAAAGTCTATATGAAAAACAAAAATAACATCTTCAGTTTTTCTC
CCACTGGGTCACCTCAAGGATCAGAGGCCAGGAAAAAAAAAAAAAAGACTCCCTGGATCTCTGAATATATGCAAAAAGAAGGCCCCATTT
AGTGGAGCCAGCAATCCTGTTCAGTCAACAAGTATTTTAACTCTCAGTCCAACATTATTTGAATTGAGCACCTCAAGCATGCTTAGCAAT
GTTCTAATCACTATGGACAGATGTAAAAGAAACTATACATCATTTTTGCCCTCTGCCTGTTTTCCAGACATACAGGTTCTGTGGAATAAG
ATACTGGACTCCTCTTCCCAAGATGGCACTTCTTTTTATTTCTTGTCCCCAGTGTGTACCTTTTAAAATTATTCCCTCTCAACAAAACTT
TATAGGCAGTCTTCTGCAGACTTAACGTGTTTTCTGTCATAGTTAGATGTGATAATTCTAAGAGTGTCTATGACTTATTTCCTTCACTTA
ATTCTATCCACAGTCAAAAATCCCCCAAGGAGGAAAGCTGAAAGATGCACTGCCATATTATCTTTCTTAACTTTTTCCAACACATAATCC
TCTCCAACTGGATTATAAATAAATTGAAAATAACTCATTATACCAATTCACTATTTTATTTTTTAATGAATTAAAACTAGAAAACAAATT
GATGCAAACCCTGGAAGTCAGTTGATTACTATATACTACAGCAGAATGACTCAGATTTCATAGAAAGGAGCAACCAAAATGTCACAACCC
AAAACTTTACAAGCTTTGCTTCAGAATTAGATTGCTTTATAATTCTTGAATGAGGCAATTTCAAGATATTTGTAAAAGAACAGTAAACAT
TGGTAAGAATGAGCTTTCAACTCATAGGCTTATTTCCAATTTAATTGACCATACTGGATACTTAGGTCAAATTTCTGTTCTCTCTTCCCC
AAATAATATTAAAGTATTATTTGAACTTTTTAAGATGAGGCAGTTCCCCTGAAAAAGTTAATGCAGCTCTCCATCAGAATCCACTCTTCT
AGGGATATGAAAATCTCTTAACACCCACCCTACATACACAGACACACACACACACACACACACACACACACACACACACATTCACCCTAA
GGATCCAATGGAATACTGAAAAGAAATCACTTCCTTGAAAATTTTATTAAAAAACAAACAAACAAACAAAAAGCCTGTCCACCCTTGAGA
ATCCTTCCTCTCCTTGGAACGTCAATGTTTGTGTAGATGAAACCATCTCATGCTCTGTGGCTCCAGGGTTTCTGTTACTATTTTATGCAC
TTGGGAGAAGGCTTAGAATAAAAGATGTAGCACATTTTGCTTTCCCATTTATTGTTTGGCCAGCTATGCCAATGTGGTGCTATTGTTTCT
TTAAGAAAGTACTTGACTAAAAAAAAAAGAAAAAAAGAAAAAAAAGAAAGCATAGACATATTTTTTTAAAGTATAAAAACAACAATTCTA
TAGATAGATGGCTTAATAAAATAGCATTAGGTCTATCTAGCCACCACCACCTTTCAACTTTTTATCACTCACAAGTAGTGTACTGTTCAC
CAAATTGTGAATTTGGGGGTGCAGGGGCAGGAGTTGGAAATTTTTTAAAGTTAGAAGGCTCCATTGTTTTGTTGGCTCTCAAACTTAGCA
AAATTAGCAATATATTATCCAATCTTCTGAACTTGATCAAGAGCATGGAGAATAAACGCGGGAAAAAAGATCTTATAGGCAAATAGAAGA
ATTTAAAAGATAAGTAAGTTCCTTATTGATTTTTGTGCACTCTGCTCTAAAACAGATATTCAGCAAGTGGAGAAAATAAGAACAAAGAGA
AAAAATACATAGATTTACCTGCAAAAAATAGCTTCTGCCAAATCCCCCTTGGGTATTCTTTGGCATTTACTGGTTTATAGAAGACATTCT
CCCTTCACCCAGACATCTCAAAGAGCAGTAGCTCTCATGAAAAGCAATCACTGATCTCATTTGGGAAATGTTGGAAAGTATTTCCTTATG
AGATGGGGGTTATCTACTGATAAAGAAAGAATTTATGAGAAATTGTTGAAAGAGATGGCTAACAATCTGTGAAGATTTTTTGTTTCTTGT
TTTTGTTTTTTTTTTTTTTTTACTTTATACAGTCTTTATGAATTTCTTAATGTTCAAAATGACTTGGTTCTTTTCTTCTTTTTTTATATC
AGAATGAGGAATAATAAGTTAAACCCACATAGACTCTTTAAAACTATAGGCTAGATAGAAATGTATGTTTGACTTGTTGAAGCTATAATC
AGACTATTTAAAATGTTTTGCTATTTTTAATCTTAAAAGATTGTGCTAATTTATTAGAGCAGAACCTGTTTGGCTCTCCTCAGAAGAAAG
AATCTTTCCATTCAAATCACATGGCTTTCCACCAATATTTTCAAAAGATAAATCTGATTTATGCAATGGCATCATTTATTTTAAAACAGA
AGAATTGTGAAAGTTTATGCCCCTCCCTTGCAAAGACCATAAAGTCCAGATCTGGTAGGGGGGCAACAACAAAAGGAAAATGTTGTTGAT
TCTTGGTTTTGGATTTTGTTTTGTTTTCAATGCTAGTGTTTAATCCTGTAGTACATATTTGCTTATTGCTATTTTAATATTTTATAAGAC
CTTCCTGTTAGGTATTAGAAAGTGATACATAGATATCTTTTTTGTGTAATTTCTATTTAAAAAAGAGAGAAGACTGTCAGAAGCTTTAAG
TGCATATGGTACAGGATAAAGATATCAATTTAAATAACCAATTCCTATCTGGAACAATGCTTTTGTTTTTTAAAGAAACCTCTCACAGAT
AAGACAGAGGCCCAGGGGATTTTTGAAGCTGTCTTTATTCTGCCCCCATCCCAACCCAGCCCTTATTATTTTAGTATCTGCCTCAGAATT
TTATAGAGGGCTGACCAAGCTGAAACTCTAGAATTAAAGGAACCTCACTGAAAACATATATTTCACGTGTTCCCTCTTTTTTTTTTTCCT
TTTTGTGAGATGGGGTCTCGCACTGTCCCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTTAAG
CGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACTATGCCCGGCTAATTTTTTGGATTTTTAATAGAGACGG
GGTTTTACCATGTTGGCCAGGTTGGTCTCAAACTCCTGACCTTGTGATTTGCCCGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCATG
AGCCACCACACCCTGCCCATGTGTTCCCTCTTAATGTATGATTACATGGATCTTAAACATGATCCTTCTCTCCTCATTCTTCAACTATCT
TTGATGGGGTCTTTCAAGGGGAAAAAAATCCAAGCTTTTTTAAAGTAAAAAAAAAAAAAGAGAGGACACAAAACCAAATGTTACTGCTCA
ACTGAAATATGAGTTAAGATGGAGACAGAGTTTCTCCTAATAACCGGAGCTGAATTACCTTTCACTTTCAAAAACATGACCTTCCACAAT
CCTTAGAATCTGCCTTTTTTTATATTACTGAGGCCTAAAAGTAAACATTACTCATTTTATTTTGCCCAAAATGCACTGATGTAAAGTAGG
AAAAATAAAAACAGAGCTCTAAAATCCCTTTCAAGCCACCCATTGACCCCACTCACCAACTCATAGCAAAGTCACTTCTGTTAATCCCTT
AATCTGATTTTGTTTGGATATTTATCTTGTACCCGCTGCTAAACACACTGCAGGAGGGACTCTGAAACCTCAAGCTGTCTACTTACATCT
TTTATCTGTGTCTGTGTATCATGAAAATGTCTATTCAAAATATCAAAACCTTTCAAATATCACGCAGCTTATATTCAGTTTACATAAAGG
CCCCAAATACCATGTCAGATCTTTTTGGTAAAAGAGTTAATGAACTATGAGAATTGGGATTACATCATGTATTTTGCCTCATGTATTTTT
ATCACACTTATAGGCCAAGTGTGATAAATAAACTTACAGACACTGAATTAATTTCCCCTGCTACTTTGAAACCAGAAAATAATGACTGGC
CATTCGTTACATCTGTCTTAGTTGAAAAGCATATTTTTTATTAAATTAATTCTGATTGTATTTGAAATTATTATTCAATTCACTTATGGC
AGAGGAATATCAATCCTAATGACTTCTAAAAATGTAACTAATTGAATCATTATCTTACATTTACTGTTTAATAAGCATATTTTGAAAATG

>68339_68339_1_PPTC7-IGF1_PPTC7_chr12_111020614_ENST00000354300_IGF1_chr12_102869577_ENST00000337514_length(amino acids)=176AA_BP=
MVCIFTEHVRGTVPGHEARVVPVARALLEEALTEVLPEAAAGRHQSVVAAAAAAGPGVGLREAAEHGAGHQPPVREDREHRRRRPPEEAG

--------------------------------------------------------------
>68339_68339_2_PPTC7-IGF1_PPTC7_chr12_111020614_ENST00000354300_IGF1_chr12_102869577_ENST00000456098_length(transcript)=7600nt_BP=512nt
ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA
CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA
GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT
CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC
CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA
GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGGTGAAGATGCACACCATGTCCTCCTCGC
ATCTCTTCTACCTGGCGCTGTGCCTGCTCACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGATG
CTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGCTCCAGCAGTCGGAGGGCGCCTCAGACAGGCA
TCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCTG
TCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGTATCAGCCCCCATCTACCAACAAGAACACGAAGTCTCAGAGAAGGAAAG
GAAGTACATTTGAAGAACGCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAGGAAGACCCTCCTGAGGAGTGAAGAGTGACA
TGCCACCGCAGGATCCTTTGCTCTGCACGAGTTACCTGTTAAACTTTGGAACACCTACCAAAAAATAAGTTTGATAACATTTAAAAGATG
GGCGTTTCCCCCAATGAAATACACAAGTAAACATTCCAACATTGTCTTTAGGAGTGATTTGCACCTTGCAAAAATGGTCCTGGAGTTGGT
AGATTGCTGTTGATCTTTTATCAATAATGTTCTATAGAAAAGAAAAAAAAAATATATATATATATATATCTTAGTCCCTGCCTCTCAAGA
GCCACAAATGCATGGGTGTTGTATAGATCCAGTTGCACTAAATTCCTCTCTGAATCTTGGCTGCTGGAGCCATTCATTCAGCAACCTTGT
CTAAGTGGTTTATGAATTGTTTCCTTATTTGCACTTCTTTCTACACAACTCGGGCTGTTTGTTTTACAGTGTCTGATAATCTTGTTAGTC
TATACCCACCACCTCCCTTCATAACCTTTATATTTGCCGAATTTGGCCTCCTCAAAAGCAGCAGCAAGTCGTCAAGAAGCACACCAATTC
TAACCCACAAGATTCCATCTGTGGCATTTGTACCAAATATAAGTTGGATGCATTTTATTTTAGACACAAAGCTTTATTTTTCCACATCAT
GCTTACAAAAAAGAATAATGCAAATAGTTGCAACTTTGAGGCCAATCATTTTTAGGCATATGTTTTAAACATAGAAAGTTTCTTCAACTC
AAAAGAGTTCCTTCAAATGATGAGTTAATGTGCAACCTAATTAGTAACTTTCCTCTTTTTATTTTTTCCATATAGAGCACTATGTAAATT
TAGCATATCAATTATACAGGATATATCAAACAGTATGTAAAACTCTGTTTTTTAGTATAATGGTGCTATTTTGTAGTTTGTTATATGAAA
GAGTCTGGCCAAAACGGTAATACGTGAAAGCAAAACAATAGGGGAAGCCTGGAGCCAAAGATGACACAAGGGGAAGGGTACTGAAAACAC
CATCCATTTGGGAAAGAAGGCAAAGTCCCCCCAGTTATGCCTTCCAAGAGGAACTTCAGACACAAAAGTCCACTGATGCAAATTGGACTG
GCGAGTCCAGAGAGGAAACTGTGGAATGGAAAAAGCAGAAGGCTAGGAATTTTAGCAGTCCTGGTTTCTTTTTCTCATGGAAGAAATGAA
CATCTGCCAGCTGTGTCATGGACTCACCACTGTGTGACCTTGGGCAAGTCACTTCACCTCTCTGTGCCTCAGTTTCCTCATCTGCAAAAT
GGGGGCAATATGTCATCTACCTACCTCAAAGGGGTGGTATAAGGTTTAAAAAGATAAAGATTCAGATTTTTTTTACCCTGGGTTGCTGTA
AGGGTGCAACATCAGGGCGCTTGAGTTGCTGAGATGCAAGGAATTCTATAAATAACCCATTCATAGCATAGCTAGAGATTGGTGAATTGA
ATGCTCCTGACATCTCAGTTCTTGTCAGTGAAGCTATCCAAATAACTGGCCAACTAGTTGTTAAAAGCTAACAGCTCAATCTCTTAAAAC
ACTTTTCAAAATATGTGGGAAGCATTTGATTTTCAATTTGATTTTGAATTCTGCATTTGGTTTTATGAATACAAAGATAAGTGAAAAGAG
AGAAAGGAAAAGAAAAAGGAGAAAAACAAAGAGATTTCTACCAGTGAAAGGGGAATTAATTACTCTTTGTTAGCACTCACTGACTCTTCT
ATGCAGTTACTACATATCTAGTAAAACCTCGTTTAATACTATAAATAATATTCTATTCATTTTGAAAAACACAATGATTCCTTCTTTTCT
AGGCAATATAAGGAAAGTGATCCAAAATTTGAAATATTAAAATAATATCTAATAAAAAGTCACAAAGTTATCTTCTTTAACAAACTTTAC
TCTTATTCTTAGCTGTATATACATTTTTTTAAAAGTTTGTTAAAATATGCTTGACTAGAGTTTCCAGTTGAAAGGCAAAAACTTCCATCA
CAACAAGAAATTTCCCATGCCTGCTCAGAAGGGTAGCCCCTAGCTCTCTGTGAATGTGTTTTATCCATTCAACTGAAAATTGGTATCAAG
AAAGTCCACTGGTTAGTGTACTAGTCCATCATAGCCTAGAAAATGATCCCTATCTGCAGATCAAGATTTTCTCATTAGAACAATGAATTA
TCCAGCATTCAGATCTTTCTAGTCACCTTAGAACTTTTTGGTTAAAAGTACCCAGGCTTGATTATTTCATGCAAATTCTATATTTTACAT
TCTTGGAAAGTCTATATGAAAAACAAAAATAACATCTTCAGTTTTTCTCCCACTGGGTCACCTCAAGGATCAGAGGCCAGGAAAAAAAAA
AAAAAGACTCCCTGGATCTCTGAATATATGCAAAAAGAAGGCCCCATTTAGTGGAGCCAGCAATCCTGTTCAGTCAACAAGTATTTTAAC
TCTCAGTCCAACATTATTTGAATTGAGCACCTCAAGCATGCTTAGCAATGTTCTAATCACTATGGACAGATGTAAAAGAAACTATACATC
ATTTTTGCCCTCTGCCTGTTTTCCAGACATACAGGTTCTGTGGAATAAGATACTGGACTCCTCTTCCCAAGATGGCACTTCTTTTTATTT
CTTGTCCCCAGTGTGTACCTTTTAAAATTATTCCCTCTCAACAAAACTTTATAGGCAGTCTTCTGCAGACTTAACGTGTTTTCTGTCATA
GTTAGATGTGATAATTCTAAGAGTGTCTATGACTTATTTCCTTCACTTAATTCTATCCACAGTCAAAAATCCCCCAAGGAGGAAAGCTGA
AAGATGCACTGCCATATTATCTTTCTTAACTTTTTCCAACACATAATCCTCTCCAACTGGATTATAAATAAATTGAAAATAACTCATTAT
ACCAATTCACTATTTTATTTTTTAATGAATTAAAACTAGAAAACAAATTGATGCAAACCCTGGAAGTCAGTTGATTACTATATACTACAG
CAGAATGACTCAGATTTCATAGAAAGGAGCAACCAAAATGTCACAACCCAAAACTTTACAAGCTTTGCTTCAGAATTAGATTGCTTTATA
ATTCTTGAATGAGGCAATTTCAAGATATTTGTAAAAGAACAGTAAACATTGGTAAGAATGAGCTTTCAACTCATAGGCTTATTTCCAATT
TAATTGACCATACTGGATACTTAGGTCAAATTTCTGTTCTCTCTTCCCCAAATAATATTAAAGTATTATTTGAACTTTTTAAGATGAGGC
AGTTCCCCTGAAAAAGTTAATGCAGCTCTCCATCAGAATCCACTCTTCTAGGGATATGAAAATCTCTTAACACCCACCCTACATACACAG
ACACACACACACACACACACACACACACACACACACACATTCACCCTAAGGATCCAATGGAATACTGAAAAGAAATCACTTCCTTGAAAA
TTTTATTAAAAAACAAACAAACAAACAAAAAGCCTGTCCACCCTTGAGAATCCTTCCTCTCCTTGGAACGTCAATGTTTGTGTAGATGAA
ACCATCTCATGCTCTGTGGCTCCAGGGTTTCTGTTACTATTTTATGCACTTGGGAGAAGGCTTAGAATAAAAGATGTAGCACATTTTGCT
TTCCCATTTATTGTTTGGCCAGCTATGCCAATGTGGTGCTATTGTTTCTTTAAGAAAGTACTTGACTAAAAAAAAAAGAAAAAAAGAAAA
AAAAGAAAGCATAGACATATTTTTTTAAAGTATAAAAACAACAATTCTATAGATAGATGGCTTAATAAAATAGCATTAGGTCTATCTAGC
CACCACCACCTTTCAACTTTTTATCACTCACAAGTAGTGTACTGTTCACCAAATTGTGAATTTGGGGGTGCAGGGGCAGGAGTTGGAAAT
TTTTTAAAGTTAGAAGGCTCCATTGTTTTGTTGGCTCTCAAACTTAGCAAAATTAGCAATATATTATCCAATCTTCTGAACTTGATCAAG
AGCATGGAGAATAAACGCGGGAAAAAAGATCTTATAGGCAAATAGAAGAATTTAAAAGATAAGTAAGTTCCTTATTGATTTTTGTGCACT
CTGCTCTAAAACAGATATTCAGCAAGTGGAGAAAATAAGAACAAAGAGAAAAAATACATAGATTTACCTGCAAAAAATAGCTTCTGCCAA
ATCCCCCTTGGGTATTCTTTGGCATTTACTGGTTTATAGAAGACATTCTCCCTTCACCCAGACATCTCAAAGAGCAGTAGCTCTCATGAA
AAGCAATCACTGATCTCATTTGGGAAATGTTGGAAAGTATTTCCTTATGAGATGGGGGTTATCTACTGATAAAGAAAGAATTTATGAGAA
ATTGTTGAAAGAGATGGCTAACAATCTGTGAAGATTTTTTGTTTCTTGTTTTTGTTTTTTTTTTTTTTTTACTTTATACAGTCTTTATGA
ATTTCTTAATGTTCAAAATGACTTGGTTCTTTTCTTCTTTTTTTATATCAGAATGAGGAATAATAAGTTAAACCCACATAGACTCTTTAA
AACTATAGGCTAGATAGAAATGTATGTTTGACTTGTTGAAGCTATAATCAGACTATTTAAAATGTTTTGCTATTTTTAATCTTAAAAGAT
TGTGCTAATTTATTAGAGCAGAACCTGTTTGGCTCTCCTCAGAAGAAAGAATCTTTCCATTCAAATCACATGGCTTTCCACCAATATTTT
CAAAAGATAAATCTGATTTATGCAATGGCATCATTTATTTTAAAACAGAAGAATTGTGAAAGTTTATGCCCCTCCCTTGCAAAGACCATA
AAGTCCAGATCTGGTAGGGGGGCAACAACAAAAGGAAAATGTTGTTGATTCTTGGTTTTGGATTTTGTTTTGTTTTCAATGCTAGTGTTT
AATCCTGTAGTACATATTTGCTTATTGCTATTTTAATATTTTATAAGACCTTCCTGTTAGGTATTAGAAAGTGATACATAGATATCTTTT
TTGTGTAATTTCTATTTAAAAAAGAGAGAAGACTGTCAGAAGCTTTAAGTGCATATGGTACAGGATAAAGATATCAATTTAAATAACCAA
TTCCTATCTGGAACAATGCTTTTGTTTTTTAAAGAAACCTCTCACAGATAAGACAGAGGCCCAGGGGATTTTTGAAGCTGTCTTTATTCT
GCCCCCATCCCAACCCAGCCCTTATTATTTTAGTATCTGCCTCAGAATTTTATAGAGGGCTGACCAAGCTGAAACTCTAGAATTAAAGGA
ACCTCACTGAAAACATATATTTCACGTGTTCCCTCTTTTTTTTTTTCCTTTTTGTGAGATGGGGTCTCGCACTGTCCCCCAGGCTGGAGT
GCAGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTTAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAG
GCACCCACCACTATGCCCGGCTAATTTTTTGGATTTTTAATAGAGACGGGGTTTTACCATGTTGGCCAGGTTGGTCTCAAACTCCTGACC
TTGTGATTTGCCCGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCATGAGCCACCACACCCTGCCCATGTGTTCCCTCTTAATGTATGA
TTACATGGATCTTAAACATGATCCTTCTCTCCTCATTCTTCAACTATCTTTGATGGGGTCTTTCAAGGGGAAAAAAATCCAAGCTTTTTT
AAAGTAAAAAAAAAAAAAGAGAGGACACAAAACCAAATGTTACTGCTCAACTGAAATATGAGTTAAGATGGAGACAGAGTTTCTCCTAAT
AACCGGAGCTGAATTACCTTTCACTTTCAAAAACATGACCTTCCACAATCCTTAGAATCTGCCTTTTTTTATATTACTGAGGCCTAAAAG
TAAACATTACTCATTTTATTTTGCCCAAAATGCACTGATGTAAAGTAGGAAAAATAAAAACAGAGCTCTAAAATCCCTTTCAAGCCACCC
ATTGACCCCACTCACCAACTCATAGCAAAGTCACTTCTGTTAATCCCTTAATCTGATTTTGTTTGGATATTTATCTTGTACCCGCTGCTA
AACACACTGCAGGAGGGACTCTGAAACCTCAAGCTGTCTACTTACATCTTTTATCTGTGTCTGTGTATCATGAAAATGTCTATTCAAAAT
ATCAAAACCTTTCAAATATCACGCAGCTTATATTCAGTTTACATAAAGGCCCCAAATACCATGTCAGATCTTTTTGGTAAAAGAGTTAAT
GAACTATGAGAATTGGGATTACATCATGTATTTTGCCTCATGTATTTTTATCACACTTATAGGCCAAGTGTGATAAATAAACTTACAGAC
ACTGAATTAATTTCCCCTGCTACTTTGAAACCAGAAAATAATGACTGGCCATTCGTTACATCTGTCTTAGTTGAAAAGCATATTTTTTAT
TAAATTAATTCTGATTGTATTTGAAATTATTATTCAATTCACTTATGGCAGAGGAATATCAATCCTAATGACTTCTAAAAATGTAACTAA
TTGAATCATTATCTTACATTTACTGTTTAATAAGCATATTTTGAAAATGTATGGCTAGAGTGTCATAATAAAATGGTATATCTTTCTTTA

>68339_68339_2_PPTC7-IGF1_PPTC7_chr12_111020614_ENST00000354300_IGF1_chr12_102869577_ENST00000456098_length(amino acids)=176AA_BP=
MVCIFTEHVRGTVPGHEARVVPVARALLEEALTEVLPEAAAGRHQSVVAAAAAAGPGVGLREAAEHGAGHQPPVREDREHRRRRPPEEAG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPTC7-IGF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPTC7-IGF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPTC7-IGF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source