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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRAME-HDLBP (FusionGDB2 ID:68380)

Fusion Gene Summary for PRAME-HDLBP

check button Fusion gene summary
Fusion gene informationFusion gene name: PRAME-HDLBP
Fusion gene ID: 68380
HgeneTgene
Gene symbol

PRAME

HDLBP

Gene ID

23532

3069

Gene namepreferentially expressed antigen in melanomahigh density lipoprotein binding protein
SynonymsCT130|MAPE|OIP-4|OIP4HBP|PRO2900|VGL
Cytomap

22q11.22

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionmelanoma antigen preferentially expressed in tumorsOpa-interacting protein OIP4cancer/testis antigen 130opa-interacting protein 4preferentially expressed antigen of melanomavigilinHDL-binding protein
Modification date2020032020200313
UniProtAcc

PRAMEF6

Q00341

Ensembl transtripts involved in fusion geneENST00000398741, ENST00000398743, 
ENST00000405655, ENST00000539862, 
ENST00000543184, ENST00000402697, 
ENST00000406503, ENST00000424204, 
ENST00000485532, 		ENST00000476807, 
ENST00000310931, ENST00000391975, 
ENST00000391976, ENST00000427183, 
Fusion gene scores* DoF score3 X 3 X 2=1828 X 24 X 13=8736
# samples 329
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/8736*10)=-4.91284805090492
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRAME [Title/Abstract] AND HDLBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRAME(22890128)-HDLBP(242202277), # samples:1
Anticipated loss of major functional domain due to fusion event.PRAME-HDLBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRAME-HDLBP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRAME

GO:0008284

positive regulation of cell proliferation

16179254

HgenePRAME

GO:0043066

negative regulation of apoptotic process

16179254

HgenePRAME

GO:0045596

negative regulation of cell differentiation

16179254

HgenePRAME

GO:0045892

negative regulation of transcription, DNA-templated

16179254

HgenePRAME

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

16179254


check buttonFusion gene breakpoints across PRAME (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HDLBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A3Y6-01APRAMEchr22

22890128

-HDLBPchr2

242202277

-


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Fusion Gene ORF analysis for PRAME-HDLBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398741ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
5CDS-intronENST00000398743ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
5CDS-intronENST00000405655ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
5CDS-intronENST00000539862ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
5CDS-intronENST00000543184ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000398743ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000398743ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000398743ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000398743ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000405655ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000405655ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000405655ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000405655ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000539862ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000539862ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000539862ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000539862ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000543184ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000543184ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000543184ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
Frame-shiftENST00000543184ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
In-frameENST00000398741ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
In-frameENST00000398741ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
In-frameENST00000398741ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
In-frameENST00000398741ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000402697ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000402697ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000402697ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000402697ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000406503ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000406503ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000406503ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000406503ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000424204ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000424204ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000424204ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000424204ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000485532ENST00000310931PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000485532ENST00000391975PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000485532ENST00000391976PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-3CDSENST00000485532ENST00000427183PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-intronENST00000402697ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-intronENST00000406503ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-intronENST00000424204ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-
intron-intronENST00000485532ENST00000476807PRAMEchr22

22890128

-HDLBPchr2

242202277

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398741PRAMEchr2222890128-ENST00000391976HDLBPchr2242202277-610022022501836528
ENST00000398741PRAMEchr2222890128-ENST00000310931HDLBPchr2242202277-610022022501836528
ENST00000398741PRAMEchr2222890128-ENST00000391975HDLBPchr2242202277-804822022501836528
ENST00000398741PRAMEchr2222890128-ENST00000427183HDLBPchr2242202277-588322022501836528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398741ENST00000391976PRAMEchr2222890128-HDLBPchr2242202277-0.0369398260.9630602
ENST00000398741ENST00000310931PRAMEchr2222890128-HDLBPchr2242202277-0.0369398260.9630602
ENST00000398741ENST00000391975PRAMEchr2222890128-HDLBPchr2242202277-0.0274166650.9725833
ENST00000398741ENST00000427183PRAMEchr2222890128-HDLBPchr2242202277-0.037622970.96237695

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Fusion Genomic Features for PRAME-HDLBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRAME-HDLBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:22890128/chr2:242202277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRAME

PRAMEF6

HDLBP

Q00341

476FUNCTION: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66116_145631510.0RepeatLRR 1%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66207_231631510.0RepeatLRR 2%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66232_258631510.0RepeatLRR 3%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66259_294631510.0RepeatLRR 4%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66295_320631510.0RepeatLRR 5
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66321_352631510.0RepeatLRR 6
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66353_371631510.0RepeatLRR 7
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66377_404631510.0RepeatLRR 8
HgenePRAMEchr22:22890128chr2:242202277ENST00000398741-66405_429631510.0RepeatLRR 9
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66116_145632510.0RepeatLRR 1%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66207_231632510.0RepeatLRR 2%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66232_258632510.0RepeatLRR 3%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66259_294632510.0RepeatLRR 4%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66295_320632510.0RepeatLRR 5
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66321_352632510.0RepeatLRR 6
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66353_371632510.0RepeatLRR 7
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66377_404632510.0RepeatLRR 8
HgenePRAMEchr22:22890128chr2:242202277ENST00000398743-66405_429632510.0RepeatLRR 9
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66116_145631510.0RepeatLRR 1%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66207_231631510.0RepeatLRR 2%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66232_258631510.0RepeatLRR 3%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66259_294631510.0RepeatLRR 4%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66295_320631510.0RepeatLRR 5
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66321_352631510.0RepeatLRR 6
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66353_371631510.0RepeatLRR 7
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66377_404631510.0RepeatLRR 8
HgenePRAMEchr22:22890128chr2:242202277ENST00000405655-66405_429631510.0RepeatLRR 9
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55116_145631510.0RepeatLRR 1%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55207_231631510.0RepeatLRR 2%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55232_258631510.0RepeatLRR 3%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55259_294631510.0RepeatLRR 4%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55295_320631510.0RepeatLRR 5
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55321_352631510.0RepeatLRR 6
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55353_371631510.0RepeatLRR 7
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55377_404631510.0RepeatLRR 8
HgenePRAMEchr22:22890128chr2:242202277ENST00000543184-55405_429631510.0RepeatLRR 9
TgeneHDLBPchr22:22890128chr2:242202277ENST000003109310281060_113401269.0DomainKH 13
TgeneHDLBPchr22:22890128chr2:242202277ENST000003109310281135_120901269.0DomainKH 14
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028158_22901269.0DomainKH 1
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028230_30201269.0DomainKH 2
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028303_37101269.0DomainKH 3
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028372_44201269.0DomainKH 4
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028443_51401269.0DomainKH 5
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028515_58801269.0DomainKH 6
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028589_66001269.0DomainKH 7
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028661_73401269.0DomainKH 8
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028735_80701269.0DomainKH 9
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028808_88001269.0DomainKH 10
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028881_97901269.0DomainKH 11
TgeneHDLBPchr22:22890128chr2:242202277ENST00000310931028980_105901269.0DomainKH 12
TgeneHDLBPchr22:22890128chr2:242202277ENST000003919750281060_113401269.0DomainKH 13
TgeneHDLBPchr22:22890128chr2:242202277ENST000003919750281135_120901269.0DomainKH 14
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028158_22901269.0DomainKH 1
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028230_30201269.0DomainKH 2
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028303_37101269.0DomainKH 3
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028372_44201269.0DomainKH 4
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028443_51401269.0DomainKH 5
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028515_58801269.0DomainKH 6
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028589_66001269.0DomainKH 7
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028661_73401269.0DomainKH 8
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028735_80701269.0DomainKH 9
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028808_88001269.0DomainKH 10
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028881_97901269.0DomainKH 11
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391975028980_105901269.0DomainKH 12
TgeneHDLBPchr22:22890128chr2:242202277ENST000003919760281060_113401269.0DomainKH 13
TgeneHDLBPchr22:22890128chr2:242202277ENST000003919760281135_120901269.0DomainKH 14
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028158_22901269.0DomainKH 1
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028230_30201269.0DomainKH 2
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028303_37101269.0DomainKH 3
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028372_44201269.0DomainKH 4
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028443_51401269.0DomainKH 5
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028515_58801269.0DomainKH 6
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028589_66001269.0DomainKH 7
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028661_73401269.0DomainKH 8
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028735_80701269.0DomainKH 9
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028808_88001269.0DomainKH 10
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028881_97901269.0DomainKH 11
TgeneHDLBPchr22:22890128chr2:242202277ENST00000391976028980_105901269.0DomainKH 12
TgeneHDLBPchr22:22890128chr2:242202277ENST000004271830281060_113401236.0DomainKH 13
TgeneHDLBPchr22:22890128chr2:242202277ENST000004271830281135_120901236.0DomainKH 14
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028158_22901236.0DomainKH 1
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028230_30201236.0DomainKH 2
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028303_37101236.0DomainKH 3
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028372_44201236.0DomainKH 4
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028443_51401236.0DomainKH 5
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028515_58801236.0DomainKH 6
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028589_66001236.0DomainKH 7
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028661_73401236.0DomainKH 8
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028735_80701236.0DomainKH 9
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028808_88001236.0DomainKH 10
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028881_97901236.0DomainKH 11
TgeneHDLBPchr22:22890128chr2:242202277ENST00000427183028980_105901236.0DomainKH 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16116_1450510.0RepeatLRR 1%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16207_2310510.0RepeatLRR 2%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16232_2580510.0RepeatLRR 3%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16259_2940510.0RepeatLRR 4%3B degenerate
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16295_3200510.0RepeatLRR 5
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16321_3520510.0RepeatLRR 6
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16353_3710510.0RepeatLRR 7
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16377_4040510.0RepeatLRR 8
HgenePRAMEchr22:22890128chr2:242202277ENST00000402697-16405_4290510.0RepeatLRR 9


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Fusion Gene Sequence for PRAME-HDLBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68380_68380_1_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000310931_length(transcript)=6100nt_BP=2202nt
AATGTAGGGAAAGCAGGGCGGAGTCCTCTGCAGGCTCGGGGGAGGGGAGGGGCGTGAATGCGTGGATTTCTGTGGAGAGTGGAAACACGG
GGAGTCGAGGGGAGCATGCGCGGGCCTCAGAAAGTTTTGGGAAACCGACTCCTGGGAGCAGGGAGGAACGCGCGCTCCAGAGACAACTTC
GCGGTGTGGTGAACTCTCTGAGGAAAAACCATTTTGATTATTACTCTCAGACGTGCGTGGCAACAAGTGACTGAGACCTAGAAATCCAAG
CGTTGGAGGTCCTGAGGCCAGCCTAAGTCGCTTCAAAATGGAACGAAGGCGTTTGTGGGGTTCCATTCAGAGCCGATACATCAGCATGAG
TGTGTGGACAAGCCCACGGAGACTTGTGGAGCTGGCAGGGCAGAGCCTGCTGAAGGATGAGGCCCTGGCCATTGCCGCCCTGGAGTTGCT
GCCCAGGGAGCTCTTCCCGCCACTCTTCATGGCAGCCTTTGACGGGAGACACAGCCAGACCCTGAAGGCAATGGTGCAGGCCTGGCCCTT
CACCTGCCTCCCTCTGGGAGTGCTGATGAAGGGACAACATCTTCACCTGGAGACCTTCAAAGCTGTGCTTGATGGACTTGATGTGCTCCT
TGCCCAGGAGGTTCGCCCCAGGAGGTGGAAACTTCAAGTGCTGGATTTACGGAAGAACTCTCATCAGGACTTCTGGACTGTATGGTCTGG
AAACAGGGCCAGTCTGTACTCATTTCCAGAGCCAGAAGCAGCTCAGCCCATGACAAAGAAGCGAAAAGTAGATGGTTTGAGCACAGAGGC
AGAGCAGCCCTTCATTCCAGTAGAGGTGCTCGTAGACCTGTTCCTCAAGGAAGGTGCCTGTGATGAATTGTTCTCCTACCTCATTGAGAA
AGTGAAGCGAAAGAAAAATGTACTACGCCTGTGCTGTAAGAAGCTGAAGATTTTTGCAATGCCCATGCAGGATATCAAGATGATCCTGAA
AATGGTGCAGCTGGACTCTATTGAAGATTTGGAAGTGACTTGTACCTGGAAGCTACCCACCTTGGCGAAATTTTCTCCTTACCTGGGCCA
GATGATTAATCTGCGTAGACTCCTCCTCTCCCACATCCATGCATCTTCCTACATTTCCCCGGAGAAGGAAGAGCAGTATATCGCCCAGTT
CACCTCTCAGTTCCTCAGTCTGCAGTGCCTGCAGGCTCTCTATGTGGACTCTTTATTTTTCCTTAGAGGCCGCCTGGATCAGTTGCTCAG
GCACGTGATGAACCCCTTGGAAACCCTCTCAATAACTAACTGCCGGCTTTCGGAAGGGGATGTGATGCATCTGTCCCAGAGTCCCAGCGT
CAGTCAGCTAAGTGTCCTGAGTCTAAGTGGGGTCATGCTGACCGATGTAAGTCCCGAGCCCCTCCAAGCTCTGCTGGAGAGAGCCTCTGC
CACCCTCCAGGACCTGGTCTTTGATGAGTGTGGGATCACGGATGATCAGCTCCTTGCCCTCCTGCCTTCCCTGAGCCACTGCTCCCAGCT
TACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCTTGCAGAGTCTCCTGCAGCACCTCATCGGGCTGAGCAATCTGACCCA
CGTGCTGTATCCTGTCCCCCTGGAGAGTTATGAGGACATCCATGGTACCCTCCACCTGGAGAGGCTTGCCTATCTGCATGCCAGGCTCAG
GGAGTTGCTGTGTGAGTTGGGGCGGCCCAGCATGGTCTGGCTTAGTGCCAACCCCTGTCCTCACTGTGGGGACAGAACCTTCTATGACCC
GGAGCCCATCCTGTGCCCCTGTTTCATGCCTAACTAGCTGGGTGCACATATCAAATGCTTCATTCTGCATACTTGGACACTAAAGCCAGG
ATGTGCATGCATCTTGAAGCAACAAAGCAGCCACAGTTTCAGACAAATGTTCAGTGTGAGTGAGGAAAACATGTTCAGTGAGGAAAAAAC
ATTCAGACAAATGTTCAGTGAGGAAAAAAAGGGGAAGTTGGGGATAGGCAGATGTTGACTTGAGGAGTTAATGTGATCTTTGGGGAGATA
CATCTTATAGAGTTAGAAATAGAATCTGAATTTCTAAAGGGAGATTCTGGCTTGGGAAGTACATGTAGGAGTTAATCCCTGTGTAGACTG
TTGTAAAGAAACTGTTGAAAATAAAGAGAAGCAATGTGAAGCGCTCCTGACATGAGCAGCTCTGAGGAATTTCCCAGCTTTGGGGCTCAG
GTGGCTCCCAAGACCCTCCCTTGGGGCCCCAAACGATAATGATCAAAAAGAACAGAACCCTCTCCAGCCTGCTGACCCAAACCCAACCAC
ACAATGGTTTGTCTCAATCTGACCCAGCGGCTGGACCCTCCGTAAATTGTTGACGCTCTTCCCCCTTCCCGAGGTCCCGCAGGGAGCCTA
GCGCCTGGCTGTGTGTGCGGCCGCTCCTCCAGGCCTGGCCGTGCCCGCTCAGGACCTGCTCCACTGTTTAACACTAAACCAAGGTCATGA
GCATTCGTGCTAAGATAACAGACTCCAGCTCCTGGTCCACCCGGCATGTCAGTCAGCACTCTGGCCTTCATCACGAGAGCTCCGCAGCCG
TGGCTAGGATTCCACTTCCTGTGTCATGACCTCAGGAAATAAACGTCCTTGACTTTATAAAAGCCAAACTAGCTGACGTGGTGGACAGTG
AGGCGCTGCAGGTATACATGAAACCCCCAGCACACGAAGAGGCCAAGGCACCTTCCAGAGGCTTTGTGGTGCGGGACGCACCCTGGACCG
CCAGCAGCAGTGAGAAGGTGGACATTCGCTTCCCACAGAGCGGAGCCCCAGACCCCAACTGCGTCACTGTGACGGGGCTCCCAGAGAATG
TGGAGGAAGCCATCGACCACATCCTCAATCTGGAGGAGGAATACCCCCAGGACCAAATTACCATCACAGGGTACGAAAAGAACACAGAAG
CTGCCAGGGATGCTATACTGAGAATTGTGGGTGAACTTGAGCAGATGGTTTCTGAGGACGTCCCGCTGGACCACCGCGTTCACGCCCGCA
TCATTGGTGCCCGCGGCAAAGCCATTCGCAAAATCATGGACGAATTCAAGGCTTTAAGGAGTTTTAAGCTGAGTGTCACTGTAGACCCCA
AATACCATCCCAAGATTATCGGGAGAAAGGGGGCAGTAATTACCCAAATCCGGTTGGAGCATGACGTGAACATCCAGTTTCCTGATAAGG
ACGATGGGAACCAGGTGAACATACATGTCCCGGCACCTGAGCTGCAGTCTGACATCATCGCCATCACGGGCCTCGCTGCAAATTTGGACC
GGGCCAAGGCTGGACTGCTGGAGCGTGTGAAGGAGCTACAGGCCGAGCAGGAGGACCGGGCATTGGTTCCTGTCACCATTGAAGTAGAGG
TGCCCTTTGACCTTCACCGTTACGTTATTGGGCAGAAAGGAAGTGGGATCCGCAAGATGATGGATGAGTTTGAGTTCACAGTACAGAGCC
AGTTGTCCAGGAGAATGGGGACGAAGCTGGGGAGGGGAGAGAGGCTAAAGATTGTGACCCCGGCTCTCCAAGGAGGTGTGACATCATCAT
CATCTCTGGCCGGAAAGAAAAGTGTGAGGCTGCCAAGGAAGCTCTGGAGGAAGCTCAGGTGACATTAGAATGTGCTATACCCCAGAAATT
CCATCGATCTGTCATGGGCCCCAAAGGTTCCAGAATCCAGCAGATTACTCGGGATTTCAGTGTTCAAATTAAATTCCCAGACAGAGAGGA
GAACGCAGGATAATGTGGTGGAAGACTCCATGCTGGTGGACCCCAAGCACCACCGCCACTTCGTCATCCGCAGAGGCCAGGTCTTGCGGG
AGATTGCTGAAGAGTATGGCGGGGTGATGGTCAGCTTCCCACGCTCTGGCACACAGAGCGACAAAGTCACCCTCAAGGGCGCCAAGGACT
GTGTGGAGGCAGCCAAGAAACGCATTCAGGAGATCATTGAGGACCTGCAAACCAAGAGTTTCACTGTTGACATCCGCGCCAAGCCAGAAT
ACCACAAATTCCTCATCGGCAAGGGGGGCGGCAAAATTCGCAAGGTGCGCGACAGCACTGGAGCACGTGTCATCTTCCCTGCGGCTGAGG
ACAAGGACCAGGACCTGATCACCATCATTGGAAAGGAGGACGCCGTCCGAGAGGCACAGAAGGAGCTGGAGGCCTTGATCCAAAACCTGG
CCAACATAGCCGAGGTAGAGGTCTCCATCCCTGCCAAGCTGCACAACTCCCTCATTGGCACCAAGGGCCGTCTGATCCGCTCCATCATGG
AGGAGTGCGGCGGGGTCCACATTCACTTTCCCGTGGAAGGTTCAGGAAGCGACACCGTTGTTATCAGGGGCCCTTCCTCGGATGTGGAGA
AGGCCAAGAAGCAGCTCCTGCATCTGGCGGAGGAGAAGATTCGTGAAGAAAGCAACACCAAAATCGACCTTCCAGCAGAGAATAGCAATT
CAGAGACCATTATCATCACAGGCAAGCGAGCCAACTGCGAAGCTGCCCGGAGCAGGATTCTGTCTATTCAGAAAGACCTGGTGGAAAATA
GCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGGTCATCATTAACT
TTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATGG
TGGCAGATCTGGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCC
GTGAAATTCGTGACAAATTCCCAGAGTAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAA
TTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGATTAACCGGATGGA
CTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACAGTTCACATCGAGTTCACAGAGGGCG
AAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGGCCAATAGCT
TCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAGA
TGCCAAAGAAAAAGAAGACTACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGC
AGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAA
AGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCG
CTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGA
TTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCTCAGCAACTGTTGCCA
TTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCC
CACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTG
CCGAGCAGAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCAT

>68380_68380_1_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000310931_length(amino acids)=528AA_BP=
MRPRNPSVGGPEASLSRFKMERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKA
MVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKV
DGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAK
FSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMH
LSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLI

--------------------------------------------------------------
>68380_68380_2_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000391975_length(transcript)=8048nt_BP=2202nt
AATGTAGGGAAAGCAGGGCGGAGTCCTCTGCAGGCTCGGGGGAGGGGAGGGGCGTGAATGCGTGGATTTCTGTGGAGAGTGGAAACACGG
GGAGTCGAGGGGAGCATGCGCGGGCCTCAGAAAGTTTTGGGAAACCGACTCCTGGGAGCAGGGAGGAACGCGCGCTCCAGAGACAACTTC
GCGGTGTGGTGAACTCTCTGAGGAAAAACCATTTTGATTATTACTCTCAGACGTGCGTGGCAACAAGTGACTGAGACCTAGAAATCCAAG
CGTTGGAGGTCCTGAGGCCAGCCTAAGTCGCTTCAAAATGGAACGAAGGCGTTTGTGGGGTTCCATTCAGAGCCGATACATCAGCATGAG
TGTGTGGACAAGCCCACGGAGACTTGTGGAGCTGGCAGGGCAGAGCCTGCTGAAGGATGAGGCCCTGGCCATTGCCGCCCTGGAGTTGCT
GCCCAGGGAGCTCTTCCCGCCACTCTTCATGGCAGCCTTTGACGGGAGACACAGCCAGACCCTGAAGGCAATGGTGCAGGCCTGGCCCTT
CACCTGCCTCCCTCTGGGAGTGCTGATGAAGGGACAACATCTTCACCTGGAGACCTTCAAAGCTGTGCTTGATGGACTTGATGTGCTCCT
TGCCCAGGAGGTTCGCCCCAGGAGGTGGAAACTTCAAGTGCTGGATTTACGGAAGAACTCTCATCAGGACTTCTGGACTGTATGGTCTGG
AAACAGGGCCAGTCTGTACTCATTTCCAGAGCCAGAAGCAGCTCAGCCCATGACAAAGAAGCGAAAAGTAGATGGTTTGAGCACAGAGGC
AGAGCAGCCCTTCATTCCAGTAGAGGTGCTCGTAGACCTGTTCCTCAAGGAAGGTGCCTGTGATGAATTGTTCTCCTACCTCATTGAGAA
AGTGAAGCGAAAGAAAAATGTACTACGCCTGTGCTGTAAGAAGCTGAAGATTTTTGCAATGCCCATGCAGGATATCAAGATGATCCTGAA
AATGGTGCAGCTGGACTCTATTGAAGATTTGGAAGTGACTTGTACCTGGAAGCTACCCACCTTGGCGAAATTTTCTCCTTACCTGGGCCA
GATGATTAATCTGCGTAGACTCCTCCTCTCCCACATCCATGCATCTTCCTACATTTCCCCGGAGAAGGAAGAGCAGTATATCGCCCAGTT
CACCTCTCAGTTCCTCAGTCTGCAGTGCCTGCAGGCTCTCTATGTGGACTCTTTATTTTTCCTTAGAGGCCGCCTGGATCAGTTGCTCAG
GCACGTGATGAACCCCTTGGAAACCCTCTCAATAACTAACTGCCGGCTTTCGGAAGGGGATGTGATGCATCTGTCCCAGAGTCCCAGCGT
CAGTCAGCTAAGTGTCCTGAGTCTAAGTGGGGTCATGCTGACCGATGTAAGTCCCGAGCCCCTCCAAGCTCTGCTGGAGAGAGCCTCTGC
CACCCTCCAGGACCTGGTCTTTGATGAGTGTGGGATCACGGATGATCAGCTCCTTGCCCTCCTGCCTTCCCTGAGCCACTGCTCCCAGCT
TACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCTTGCAGAGTCTCCTGCAGCACCTCATCGGGCTGAGCAATCTGACCCA
CGTGCTGTATCCTGTCCCCCTGGAGAGTTATGAGGACATCCATGGTACCCTCCACCTGGAGAGGCTTGCCTATCTGCATGCCAGGCTCAG
GGAGTTGCTGTGTGAGTTGGGGCGGCCCAGCATGGTCTGGCTTAGTGCCAACCCCTGTCCTCACTGTGGGGACAGAACCTTCTATGACCC
GGAGCCCATCCTGTGCCCCTGTTTCATGCCTAACTAGCTGGGTGCACATATCAAATGCTTCATTCTGCATACTTGGACACTAAAGCCAGG
ATGTGCATGCATCTTGAAGCAACAAAGCAGCCACAGTTTCAGACAAATGTTCAGTGTGAGTGAGGAAAACATGTTCAGTGAGGAAAAAAC
ATTCAGACAAATGTTCAGTGAGGAAAAAAAGGGGAAGTTGGGGATAGGCAGATGTTGACTTGAGGAGTTAATGTGATCTTTGGGGAGATA
CATCTTATAGAGTTAGAAATAGAATCTGAATTTCTAAAGGGAGATTCTGGCTTGGGAAGTACATGTAGGAGTTAATCCCTGTGTAGACTG
TTGTAAAGAAACTGTTGAAAATAAAGAGAAGCAATGTGAAGCGCTCCTGACATGAGCAGCTCTGAGGAATTTCCCAGCTTTGGGGCTCAG
GTGGCTCCCAAGACCCTCCCTTGGGGCCCCAAACGATAATGATCAAAAAGAACAGAACCCTCTCCAGCCTGCTGACCCAAACCCAACCAC
ACAATGGTTTGTCTCAATCTGACCCAGCGGCTGGACCCTCCGTAAATTGTTGACGCTCTTCCCCCTTCCCGAGGTCCCGCAGGGAGCCTA
GCGCCTGGCTGTGTGTGCGGCCGCTCCTCCAGGCCTGGCCGTGCCCGCTCAGGACCTGCTCCACTGTTTAACACTAAACCAAGGTCATGA
GCATTCGTGCTAAGATAACAGACTCCAGCTCCTGGTCCACCCGGCATGTCAGTCAGCACTCTGGCCTTCATCACGAGAGCTCCGCAGCCG
TGGCTAGGATTCCACTTCCTGTGTCATGACCTCAGGAAATAAACGTCCTTGACTTTATAAAAGCCAAACGTTTGCCCTCTTCCTTTCCCA
CCTCCCTCCTGCCAGTTTCCCTTGGTCCAGACAGTCCTGTTTGTGGAGTGCAATCAGCCTCCTCCAGCTGCCAGAGCGCCTCAGCACAGG
TGTCAGGGTGCAAGGAAGACCTGGCAATGGACAGCAGGAGGCAGGTTCCTGGAGCTGGGGGGTGACCTGAGAGGCAGAGGGTGACGGGTT
CTCAGGCAGTCCTGATTTTACCTGCCGTGGGGTCTGAAAGCACCAAGGGTCCCTGCCCCTACCTCCACTGCCAGACCCTCAGCCTGAGGT
CTGGTGAGTGGAGCCTGGAGGCAAGGTGGTAGGCACCATCTGGGTCCCCTGTGGCCGTCACAGTGTCTGCTGTGATTGAGATGCGCACAG
GTTGGGGGAGGTAGGGCCTTACGCTTGTCCTCAGTGGGGGCAGTTTGCCTTAGATGACAGCTGGGCTCTTCTTCACACCACCTGCAGCCC
CTCCCTGCCCCTGCCCTAGCTGCTGTGTGTTCAGTTGCCTTCTTTCTACCTCAGCCGGCGTGGAGTGGTCTCTGTGCAGTTAGTGCCACC
CCACACACCCGTCTCTTGATTGAGATGTTTCTGGTGGTTATGGGTTTCCCGTGGAGCTGGGGGTGGGCGCCGTGTACCTAAGCTGGAGGC
TGGCGCTCTCCCTCAGCACAGGTGGGTCAGTGGCCAGCAGGCCCATCTGGAGTGGGAGTGGGCACTTCCACCCCGCCCACAGGCCATCCG
GCTGTGCAGGCCAGCCCCTAGGAGCAGGTCCCGGGTGACTGGCAGTTTTCACGGTCTAGGGCCGAGACGATGGCATGGGGCCTAGAGCAT
GAGGTAGAGCAGAATGCAGACCACGCCGCTGGATGCCGAGAGACCCTGCTCTCCGAGGGAGGCATCTGTGTCATGCTGTGAGGGCTGAGG
ACGGGGCCCTAGTCTCTGGTTTTCTGGTCTTAACATCCTTATCTGTGTCCGCCACGGAGGTGACTGAGCTGCTAGCGAGTTGTCCTGTCC
CAGGTACTTGAGTTTTGGAAAAGCTGACTCACGCCCATCCATCTCACAGCCCTTCCCTGGGGACAGTCGCTTCCGCCTTGACACCTCACT
CTCAGTTGAATAACTCAAGCTTGGTCATCTTCAGACTCGAATTCTTGAGTAGACCCAGACGGCTTAGCCCAAGTCTAGTTGCAGCTGCCT
CGGCAAGTCCCCATTTGCTCAGGCAGCCCTGAATGGGCCTGTTTACAGGAATGGTAAATTGGGATTGGAAGGAATATAGCTTCCAGCTTC
ATAGGCTAGGGTGACCACGGCTTAGGAAACAGGGAAAGAAAGCAAGGCCCTTTTCCTGCCTTTCCCGGGATCTGTCTACTCCACCTCCAC
GGGGGAGGCCAGTGGGGAAGGGCTGTCACCTCTTCCCCATCTGCATGAGTTCTGGAACTCTGTCCTGTTGGCTGCTTGCTTCCAGCTCCC
CCCAATCTCCATCGCAGCGGGTTCCTCCTGTCTTTTCTACAGTGTCATAAAACATCCTGCCCCTACCCTCTCCCAAAGGTCAATTTTAAT
TCTCACCAAGTTTTGCACATCTCTGTATGTCGCTTGATGTCTTAGACGCGAGCCCTTTCCTAAACTGTTCAGCGCTCTCTTTTCCTTTGG
GTGGTTGTTGCAAGGGTGATGACATGACTGTCCCCAGGCCTGTCTCCCTGAAGCGTCTGTGCTGTCAGGACAGCCCTGGGCAGAGATGAG
GCAGGGGTGAGGCGTGCGTGTGCTTTTCCTCCTTGTTGGATGTCTTCCATATCATCTGTTTCCATAGCTACAATCCATCCCTTGGCCTTA
ACTTTGGAATTTGGAGATTATATGCAAACATGTGTAAAGGCTCATGAATATGGATGACACTGGAATTTTATAAATTCTAAAATAAAACCC
GAAACCAGATGTAGCATGCTGGGACTCATTTTGTCACTAGCTGACGTGGTGGACAGTGAGGCGCTGCAGGTATACATGAAACCCCCAGCA
CACGAAGAGGCCAAGGCACCTTCCAGAGGCTTTGTGGTGCGGGACGCACCCTGGACCGCCAGCAGCAGTGAGAAGGTGGACATTCGCTTC
CCACAGAGCGGAGCCCCAGACCCCAACTGCGTCACTGTGACGGGGCTCCCAGAGAATGTGGAGGAAGCCATCGACCACATCCTCAATCTG
GAGGAGGAATACCCCCAGGACCAAATTACCATCACAGGGTACGAAAAGAACACAGAAGCTGCCAGGGATGCTATACTGAGAATTGTGGGT
GAACTTGAGCAGATGGTTTCTGAGGACGTCCCGCTGGACCACCGCGTTCACGCCCGCATCATTGGTGCCCGCGGCAAAGCCATTCGCAAA
ATCATGGACGAATTCAAGGCTTTAAGGAGTTTTAAGCTGAGTGTCACTGTAGACCCCAAATACCATCCCAAGATTATCGGGAGAAAGGGG
GCAGTAATTACCCAAATCCGGTTGGAGCATGACGTGAACATCCAGTTTCCTGATAAGGACGATGGGAACCAGGTGAACATACATGTCCCG
GCACCTGAGCTGCAGTCTGACATCATCGCCATCACGGGCCTCGCTGCAAATTTGGACCGGGCCAAGGCTGGACTGCTGGAGCGTGTGAAG
GAGCTACAGGCCGAGCAGGAGGACCGGGCATTGGTTCCTGTCACCATTGAAGTAGAGGTGCCCTTTGACCTTCACCGTTACGTTATTGGG
CAGAAAGGAAGTGGGATCCGCAAGATGATGGATGAGTTTGAGTTCACAGTACAGAGCCAGTTGTCCAGGAGAATGGGGACGAAGCTGGGG
AGGGGAGAGAGGCTAAAGATTGTGACCCCGGCTCTCCAAGGAGGTGTGACATCATCATCATCTCTGGCCGGAAAGAAAAGTGTGAGGCTG
CCAAGGAAGCTCTGGAGGAAGCTCAGGTGACATTAGAATGTGCTATACCCCAGAAATTCCATCGATCTGTCATGGGCCCCAAAGGTTCCA
GAATCCAGCAGATTACTCGGGATTTCAGTGTTCAAATTAAATTCCCAGACAGAGAGGAGAACGCAGGATAATGTGGTGGAAGACTCCATG
CTGGTGGACCCCAAGCACCACCGCCACTTCGTCATCCGCAGAGGCCAGGTCTTGCGGGAGATTGCTGAAGAGTATGGCGGGGTGATGGTC
AGCTTCCCACGCTCTGGCACACAGAGCGACAAAGTCACCCTCAAGGGCGCCAAGGACTGTGTGGAGGCAGCCAAGAAACGCATTCAGGAG
ATCATTGAGGACCTGCAAACCAAGAGTTTCACTGTTGACATCCGCGCCAAGCCAGAATACCACAAATTCCTCATCGGCAAGGGGGGCGGC
AAAATTCGCAAGGTGCGCGACAGCACTGGAGCACGTGTCATCTTCCCTGCGGCTGAGGACAAGGACCAGGACCTGATCACCATCATTGGA
AAGGAGGACGCCGTCCGAGAGGCACAGAAGGAGCTGGAGGCCTTGATCCAAAACCTGGCCAACATAGCCGAGGTAGAGGTCTCCATCCCT
GCCAAGCTGCACAACTCCCTCATTGGCACCAAGGGCCGTCTGATCCGCTCCATCATGGAGGAGTGCGGCGGGGTCCACATTCACTTTCCC
GTGGAAGGTTCAGGAAGCGACACCGTTGTTATCAGGGGCCCTTCCTCGGATGTGGAGAAGGCCAAGAAGCAGCTCCTGCATCTGGCGGAG
GAGAAGATTCGTGAAGAAAGCAACACCAAAATCGACCTTCCAGCAGAGAATAGCAATTCAGAGACCATTATCATCACAGGCAAGCGAGCC
AACTGCGAAGCTGCCCGGAGCAGGATTCTGTCTATTCAGAAAGACCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAG
TTTCACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTC
CAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGAAAATGAGCGTACCAAGGAT
CTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGTAAACA
GAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCG
TGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCC
ACAGGCACCTCATTGGGAAGAGCGGTGCCAACAGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAG
GATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGG
CTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAGATGCCAAAGAAAAAGAAGACTACAACCATTGCA
GTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTT
GAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCC
AAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATC
ATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCT
CAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGC
AAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAG
ATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGAAGCAAAAATCTGCCTTGAGATCA
TGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGA

>68380_68380_2_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000391975_length(amino acids)=528AA_BP=
MRPRNPSVGGPEASLSRFKMERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKA
MVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKV
DGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAK
FSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMH
LSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLI

--------------------------------------------------------------
>68380_68380_3_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000391976_length(transcript)=6100nt_BP=2202nt
AATGTAGGGAAAGCAGGGCGGAGTCCTCTGCAGGCTCGGGGGAGGGGAGGGGCGTGAATGCGTGGATTTCTGTGGAGAGTGGAAACACGG
GGAGTCGAGGGGAGCATGCGCGGGCCTCAGAAAGTTTTGGGAAACCGACTCCTGGGAGCAGGGAGGAACGCGCGCTCCAGAGACAACTTC
GCGGTGTGGTGAACTCTCTGAGGAAAAACCATTTTGATTATTACTCTCAGACGTGCGTGGCAACAAGTGACTGAGACCTAGAAATCCAAG
CGTTGGAGGTCCTGAGGCCAGCCTAAGTCGCTTCAAAATGGAACGAAGGCGTTTGTGGGGTTCCATTCAGAGCCGATACATCAGCATGAG
TGTGTGGACAAGCCCACGGAGACTTGTGGAGCTGGCAGGGCAGAGCCTGCTGAAGGATGAGGCCCTGGCCATTGCCGCCCTGGAGTTGCT
GCCCAGGGAGCTCTTCCCGCCACTCTTCATGGCAGCCTTTGACGGGAGACACAGCCAGACCCTGAAGGCAATGGTGCAGGCCTGGCCCTT
CACCTGCCTCCCTCTGGGAGTGCTGATGAAGGGACAACATCTTCACCTGGAGACCTTCAAAGCTGTGCTTGATGGACTTGATGTGCTCCT
TGCCCAGGAGGTTCGCCCCAGGAGGTGGAAACTTCAAGTGCTGGATTTACGGAAGAACTCTCATCAGGACTTCTGGACTGTATGGTCTGG
AAACAGGGCCAGTCTGTACTCATTTCCAGAGCCAGAAGCAGCTCAGCCCATGACAAAGAAGCGAAAAGTAGATGGTTTGAGCACAGAGGC
AGAGCAGCCCTTCATTCCAGTAGAGGTGCTCGTAGACCTGTTCCTCAAGGAAGGTGCCTGTGATGAATTGTTCTCCTACCTCATTGAGAA
AGTGAAGCGAAAGAAAAATGTACTACGCCTGTGCTGTAAGAAGCTGAAGATTTTTGCAATGCCCATGCAGGATATCAAGATGATCCTGAA
AATGGTGCAGCTGGACTCTATTGAAGATTTGGAAGTGACTTGTACCTGGAAGCTACCCACCTTGGCGAAATTTTCTCCTTACCTGGGCCA
GATGATTAATCTGCGTAGACTCCTCCTCTCCCACATCCATGCATCTTCCTACATTTCCCCGGAGAAGGAAGAGCAGTATATCGCCCAGTT
CACCTCTCAGTTCCTCAGTCTGCAGTGCCTGCAGGCTCTCTATGTGGACTCTTTATTTTTCCTTAGAGGCCGCCTGGATCAGTTGCTCAG
GCACGTGATGAACCCCTTGGAAACCCTCTCAATAACTAACTGCCGGCTTTCGGAAGGGGATGTGATGCATCTGTCCCAGAGTCCCAGCGT
CAGTCAGCTAAGTGTCCTGAGTCTAAGTGGGGTCATGCTGACCGATGTAAGTCCCGAGCCCCTCCAAGCTCTGCTGGAGAGAGCCTCTGC
CACCCTCCAGGACCTGGTCTTTGATGAGTGTGGGATCACGGATGATCAGCTCCTTGCCCTCCTGCCTTCCCTGAGCCACTGCTCCCAGCT
TACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCTTGCAGAGTCTCCTGCAGCACCTCATCGGGCTGAGCAATCTGACCCA
CGTGCTGTATCCTGTCCCCCTGGAGAGTTATGAGGACATCCATGGTACCCTCCACCTGGAGAGGCTTGCCTATCTGCATGCCAGGCTCAG
GGAGTTGCTGTGTGAGTTGGGGCGGCCCAGCATGGTCTGGCTTAGTGCCAACCCCTGTCCTCACTGTGGGGACAGAACCTTCTATGACCC
GGAGCCCATCCTGTGCCCCTGTTTCATGCCTAACTAGCTGGGTGCACATATCAAATGCTTCATTCTGCATACTTGGACACTAAAGCCAGG
ATGTGCATGCATCTTGAAGCAACAAAGCAGCCACAGTTTCAGACAAATGTTCAGTGTGAGTGAGGAAAACATGTTCAGTGAGGAAAAAAC
ATTCAGACAAATGTTCAGTGAGGAAAAAAAGGGGAAGTTGGGGATAGGCAGATGTTGACTTGAGGAGTTAATGTGATCTTTGGGGAGATA
CATCTTATAGAGTTAGAAATAGAATCTGAATTTCTAAAGGGAGATTCTGGCTTGGGAAGTACATGTAGGAGTTAATCCCTGTGTAGACTG
TTGTAAAGAAACTGTTGAAAATAAAGAGAAGCAATGTGAAGCGCTCCTGACATGAGCAGCTCTGAGGAATTTCCCAGCTTTGGGGCTCAG
GTGGCTCCCAAGACCCTCCCTTGGGGCCCCAAACGATAATGATCAAAAAGAACAGAACCCTCTCCAGCCTGCTGACCCAAACCCAACCAC
ACAATGGTTTGTCTCAATCTGACCCAGCGGCTGGACCCTCCGTAAATTGTTGACGCTCTTCCCCCTTCCCGAGGTCCCGCAGGGAGCCTA
GCGCCTGGCTGTGTGTGCGGCCGCTCCTCCAGGCCTGGCCGTGCCCGCTCAGGACCTGCTCCACTGTTTAACACTAAACCAAGGTCATGA
GCATTCGTGCTAAGATAACAGACTCCAGCTCCTGGTCCACCCGGCATGTCAGTCAGCACTCTGGCCTTCATCACGAGAGCTCCGCAGCCG
TGGCTAGGATTCCACTTCCTGTGTCATGACCTCAGGAAATAAACGTCCTTGACTTTATAAAAGCCAAACTAGCTGACGTGGTGGACAGTG
AGGCGCTGCAGGTATACATGAAACCCCCAGCACACGAAGAGGCCAAGGCACCTTCCAGAGGCTTTGTGGTGCGGGACGCACCCTGGACCG
CCAGCAGCAGTGAGAAGGTGGACATTCGCTTCCCACAGAGCGGAGCCCCAGACCCCAACTGCGTCACTGTGACGGGGCTCCCAGAGAATG
TGGAGGAAGCCATCGACCACATCCTCAATCTGGAGGAGGAATACCCCCAGGACCAAATTACCATCACAGGGTACGAAAAGAACACAGAAG
CTGCCAGGGATGCTATACTGAGAATTGTGGGTGAACTTGAGCAGATGGTTTCTGAGGACGTCCCGCTGGACCACCGCGTTCACGCCCGCA
TCATTGGTGCCCGCGGCAAAGCCATTCGCAAAATCATGGACGAATTCAAGGCTTTAAGGAGTTTTAAGCTGAGTGTCACTGTAGACCCCA
AATACCATCCCAAGATTATCGGGAGAAAGGGGGCAGTAATTACCCAAATCCGGTTGGAGCATGACGTGAACATCCAGTTTCCTGATAAGG
ACGATGGGAACCAGGTGAACATACATGTCCCGGCACCTGAGCTGCAGTCTGACATCATCGCCATCACGGGCCTCGCTGCAAATTTGGACC
GGGCCAAGGCTGGACTGCTGGAGCGTGTGAAGGAGCTACAGGCCGAGCAGGAGGACCGGGCATTGGTTCCTGTCACCATTGAAGTAGAGG
TGCCCTTTGACCTTCACCGTTACGTTATTGGGCAGAAAGGAAGTGGGATCCGCAAGATGATGGATGAGTTTGAGTTCACAGTACAGAGCC
AGTTGTCCAGGAGAATGGGGACGAAGCTGGGGAGGGGAGAGAGGCTAAAGATTGTGACCCCGGCTCTCCAAGGAGGTGTGACATCATCAT
CATCTCTGGCCGGAAAGAAAAGTGTGAGGCTGCCAAGGAAGCTCTGGAGGAAGCTCAGGTGACATTAGAATGTGCTATACCCCAGAAATT
CCATCGATCTGTCATGGGCCCCAAAGGTTCCAGAATCCAGCAGATTACTCGGGATTTCAGTGTTCAAATTAAATTCCCAGACAGAGAGGA
GAACGCAGGATAATGTGGTGGAAGACTCCATGCTGGTGGACCCCAAGCACCACCGCCACTTCGTCATCCGCAGAGGCCAGGTCTTGCGGG
AGATTGCTGAAGAGTATGGCGGGGTGATGGTCAGCTTCCCACGCTCTGGCACACAGAGCGACAAAGTCACCCTCAAGGGCGCCAAGGACT
GTGTGGAGGCAGCCAAGAAACGCATTCAGGAGATCATTGAGGACCTGCAAACCAAGAGTTTCACTGTTGACATCCGCGCCAAGCCAGAAT
ACCACAAATTCCTCATCGGCAAGGGGGGCGGCAAAATTCGCAAGGTGCGCGACAGCACTGGAGCACGTGTCATCTTCCCTGCGGCTGAGG
ACAAGGACCAGGACCTGATCACCATCATTGGAAAGGAGGACGCCGTCCGAGAGGCACAGAAGGAGCTGGAGGCCTTGATCCAAAACCTGG
CCAACATAGCCGAGGTAGAGGTCTCCATCCCTGCCAAGCTGCACAACTCCCTCATTGGCACCAAGGGCCGTCTGATCCGCTCCATCATGG
AGGAGTGCGGCGGGGTCCACATTCACTTTCCCGTGGAAGGTTCAGGAAGCGACACCGTTGTTATCAGGGGCCCTTCCTCGGATGTGGAGA
AGGCCAAGAAGCAGCTCCTGCATCTGGCGGAGGAGAAGATTCGTGAAGAAAGCAACACCAAAATCGACCTTCCAGCAGAGAATAGCAATT
CAGAGACCATTATCATCACAGGCAAGCGAGCCAACTGCGAAGCTGCCCGGAGCAGGATTCTGTCTATTCAGAAAGACCTGGTGGAAAATA
GCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGGTCATCATTAACT
TTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATGG
TGGCAGATCTGGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCC
GTGAAATTCGTGACAAATTCCCAGAGTAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAA
TTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGATTAACCGGATGGA
CTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACAGTTCACATCGAGTTCACAGAGGGCG
AAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGGCCAATAGCT
TCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAGA
TGCCAAAGAAAAAGAAGACTACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGC
AGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAA
AGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCG
CTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGA
TTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCTCAGCAACTGTTGCCA
TTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCC
CACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTG
CCGAGCAGAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCAT

>68380_68380_3_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000391976_length(amino acids)=528AA_BP=
MRPRNPSVGGPEASLSRFKMERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKA
MVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKV
DGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAK
FSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMH
LSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLI

--------------------------------------------------------------
>68380_68380_4_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000427183_length(transcript)=5883nt_BP=2202nt
AATGTAGGGAAAGCAGGGCGGAGTCCTCTGCAGGCTCGGGGGAGGGGAGGGGCGTGAATGCGTGGATTTCTGTGGAGAGTGGAAACACGG
GGAGTCGAGGGGAGCATGCGCGGGCCTCAGAAAGTTTTGGGAAACCGACTCCTGGGAGCAGGGAGGAACGCGCGCTCCAGAGACAACTTC
GCGGTGTGGTGAACTCTCTGAGGAAAAACCATTTTGATTATTACTCTCAGACGTGCGTGGCAACAAGTGACTGAGACCTAGAAATCCAAG
CGTTGGAGGTCCTGAGGCCAGCCTAAGTCGCTTCAAAATGGAACGAAGGCGTTTGTGGGGTTCCATTCAGAGCCGATACATCAGCATGAG
TGTGTGGACAAGCCCACGGAGACTTGTGGAGCTGGCAGGGCAGAGCCTGCTGAAGGATGAGGCCCTGGCCATTGCCGCCCTGGAGTTGCT
GCCCAGGGAGCTCTTCCCGCCACTCTTCATGGCAGCCTTTGACGGGAGACACAGCCAGACCCTGAAGGCAATGGTGCAGGCCTGGCCCTT
CACCTGCCTCCCTCTGGGAGTGCTGATGAAGGGACAACATCTTCACCTGGAGACCTTCAAAGCTGTGCTTGATGGACTTGATGTGCTCCT
TGCCCAGGAGGTTCGCCCCAGGAGGTGGAAACTTCAAGTGCTGGATTTACGGAAGAACTCTCATCAGGACTTCTGGACTGTATGGTCTGG
AAACAGGGCCAGTCTGTACTCATTTCCAGAGCCAGAAGCAGCTCAGCCCATGACAAAGAAGCGAAAAGTAGATGGTTTGAGCACAGAGGC
AGAGCAGCCCTTCATTCCAGTAGAGGTGCTCGTAGACCTGTTCCTCAAGGAAGGTGCCTGTGATGAATTGTTCTCCTACCTCATTGAGAA
AGTGAAGCGAAAGAAAAATGTACTACGCCTGTGCTGTAAGAAGCTGAAGATTTTTGCAATGCCCATGCAGGATATCAAGATGATCCTGAA
AATGGTGCAGCTGGACTCTATTGAAGATTTGGAAGTGACTTGTACCTGGAAGCTACCCACCTTGGCGAAATTTTCTCCTTACCTGGGCCA
GATGATTAATCTGCGTAGACTCCTCCTCTCCCACATCCATGCATCTTCCTACATTTCCCCGGAGAAGGAAGAGCAGTATATCGCCCAGTT
CACCTCTCAGTTCCTCAGTCTGCAGTGCCTGCAGGCTCTCTATGTGGACTCTTTATTTTTCCTTAGAGGCCGCCTGGATCAGTTGCTCAG
GCACGTGATGAACCCCTTGGAAACCCTCTCAATAACTAACTGCCGGCTTTCGGAAGGGGATGTGATGCATCTGTCCCAGAGTCCCAGCGT
CAGTCAGCTAAGTGTCCTGAGTCTAAGTGGGGTCATGCTGACCGATGTAAGTCCCGAGCCCCTCCAAGCTCTGCTGGAGAGAGCCTCTGC
CACCCTCCAGGACCTGGTCTTTGATGAGTGTGGGATCACGGATGATCAGCTCCTTGCCCTCCTGCCTTCCCTGAGCCACTGCTCCCAGCT
TACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCTTGCAGAGTCTCCTGCAGCACCTCATCGGGCTGAGCAATCTGACCCA
CGTGCTGTATCCTGTCCCCCTGGAGAGTTATGAGGACATCCATGGTACCCTCCACCTGGAGAGGCTTGCCTATCTGCATGCCAGGCTCAG
GGAGTTGCTGTGTGAGTTGGGGCGGCCCAGCATGGTCTGGCTTAGTGCCAACCCCTGTCCTCACTGTGGGGACAGAACCTTCTATGACCC
GGAGCCCATCCTGTGCCCCTGTTTCATGCCTAACTAGCTGGGTGCACATATCAAATGCTTCATTCTGCATACTTGGACACTAAAGCCAGG
ATGTGCATGCATCTTGAAGCAACAAAGCAGCCACAGTTTCAGACAAATGTTCAGTGTGAGTGAGGAAAACATGTTCAGTGAGGAAAAAAC
ATTCAGACAAATGTTCAGTGAGGAAAAAAAGGGGAAGTTGGGGATAGGCAGATGTTGACTTGAGGAGTTAATGTGATCTTTGGGGAGATA
CATCTTATAGAGTTAGAAATAGAATCTGAATTTCTAAAGGGAGATTCTGGCTTGGGAAGTACATGTAGGAGTTAATCCCTGTGTAGACTG
TTGTAAAGAAACTGTTGAAAATAAAGAGAAGCAATGTGAAGCGCTCCTGACATGAGCAGCTCTGAGGAATTTCCCAGCTTTGGGGCTCAG
GTGGCTCCCAAGACCCTCCCTTGGGGCCCCAAACGATAATGATCAAAAAGAACAGAACCCTCTCCAGCCTGCTGACCCAAACCCAACCAC
ACAATGGTTTGTCTCAATCTGACCCAGCGGCTGGACCCTCCGTAAATTGTTGACGCTCTTCCCCCTTCCCGAGGTCCCGCAGGGAGCCTA
GCGCCTGGCTGTGTGTGCGGCCGCTCCTCCAGGCCTGGCCGTGCCCGCTCAGGACCTGCTCCACTGTTTAACACTAAACCAAGGTCATGA
GCATTCGTGCTAAGATAACAGACTCCAGCTCCTGGTCCACCCGGCATGTCAGTCAGCACTCTGGCCTTCATCACGAGAGCTCCGCAGCCG
TGGCTAGGATTCCACTTCCTGTGTCATGACCTCAGGAAATAAACGTCCTTGACTTTATCTAGCTGACGTGGTGGACAGTGAGGCGCTGCA
GGTATACATGAAACCCCCAGCACACGAAGAGGCCAAGGCACCTTCCAGAGGCTTTGTGGTGCGGGACGCACCCTGGACCGCCAGCAGCAG
TGAGAAGGTGGACATTCGCTTCCCACAGAGCGGAGCCCCAGACCCCAACTGCGTCACTGTGACGGGGCTCCCAGAGAATGTGGAGGAAGC
CATCGACCACATCCTCAATCTGGAGGAGGAATACCCCCAGGACCAAATTACCATCACAGGGTACGAAAAGAACACAGAAGCTGCCAGGGA
TGCTATACTGAGAATTGTGGGTGAACTTGAGCAGATGGTTTCTGAGGACGTCCCGCTGGACCACCGCGTTCACGCCCGCATCATTGGTGC
CCGCGGCAAAGCCATTCGCAAAATCATGGACGAATTCAAGGCTTTAAGGAGTTTTAAGCTGAGTGTCACTGTAGACCCCAAATACCATCC
CAAGATTATCGGGAGAAAGGGGGCAGTAATTACCCAAATCCGGTTGGAGCATGACGTGAACATCCAGTTTCCTGATAAGGACGATGGGAA
CCAGGTGAACATACATGTCCCGGCACCTGAGCTGCAGTCTGACATCATCGCCATCACGGGCCTCGCTGCAAATTTGGACCGGGCCAAGGC
TGGACTGCTGGAGCGTGTGAAGGAGCTACAGGCCGAGCAGGAGGACCGGGCATTGGTTCCTGTCACCATTGAAGTAGAGGTGCCCTTTGA
CCTTCACCGTTACGTTATTGGGCAGAAAGGAAGTGGGATCCGCAAGATGATGGATGAGTTTGAGTTCACAGTACAGAGCCAGTTGTCCAG
GAGAATGGGGACGAAGCTGGGGAGGGGAGAGAGGCTAAAGATTGTGACCCCGGCTCTCCAAGGAGGTGTGACATCATCATCATCTCTGGC
CGGAAAGAAAAGTGTGAGGCTGCCAAGGAAGCTCTGGAGGAAGCTCAGGTGACATTAGAATGTGCTATACCCCAGAAATTCCATCGATCT
GTCATGGGCCCCAAAGGTTCCAGAATCCAGCAGATTACTCGGGATTTCAGTGTTCAAATTAAATTCCCAGACAGAGAGGAGAACGCAGGA
TAATGTGGTGGAAGACTCCATGCTGGTGGACCCCAAGCACCACCGCCACTTCGTCATCCGCAGAGGCCAGGTCTTGCGGGAGATTGCTGA
AGAGTATGGCGGGGTGATGGTCAGCTTCCCACGCTCTGGCACACAGAGCGACAAAGTCACCCTCAAGGGCGCCAAGGACTGTGTGGAGGC
AGCCAAGAAACGCATTCAGGAGATCATTGAGGACCTGCAAACCAAGAGTTTCACTGTTGACATCCGCGCCAAGCCAGAATACCACAAATT
CCTCATCGGCAAGGGGGGCGGCAAAATTCGCAAGGTGCGCGACAGCACTGGAGCACGTGTCATCTTCCCTGCGGCTGAGGACAAGGACCA
GGACCTGATCACCATCATTGGAAAGGAGGACGCCGTCCGAGAGGCACAGAAGGAGCTGGAGGCCTTGATCCAAAACCTGGCCAACATAGC
CGAGGTAGAGGTCTCCATCCCTGCCAAGCTGCACAACTCCCTCATTGGCACCAAGGGCCGTCTGATCCGCTCCATCATGGAGGAGTGCGG
CGGGGTCCACATTCACTTTCCCGTGGAAGGTTCAGGAAGCGACACCGTTGTTATCAGGGGCCCTTCCTCGGATGTGGAGAAGGCCAAGAA
GCAGCTCCTGCATCTGGCGGAGGAGAAGATTCGTGAAGAAAGCAACACCAAAATCGACCTTCCAGCAGAGAATAGCAATTCAGAGACCAT
TATCATCACAGGCAAGCGAGCCAACTGCGAAGCTGCCCGGAGCAGGATTCTGTCTATTCAGAAAGACCTGGTGGAAAATAGCTATTCAAT
TTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGGTCATCATTAACTTTCCAGACCC
AGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATGGTGGCAGATCT
GGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCG
TGACAAATTCCCAGAGTAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTGATCCGC
ATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGATTAACCGGATGGACTATGTGGAG
ATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACAGTTCACATCGAGTTCACAGAGGGCGAAGACAAGAT
CACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGGCCAATAGCTTCACCGTCTC
CTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAGATGCCAAAGGA
CAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCA
GGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGC
TGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAA
TGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCAC
TGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGAAGCAAAAATCTGCCTTGAGATCATGCAG
AGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCT

>68380_68380_4_PRAME-HDLBP_PRAME_chr22_22890128_ENST00000398741_HDLBP_chr2_242202277_ENST00000427183_length(amino acids)=528AA_BP=
MRPRNPSVGGPEASLSRFKMERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKA
MVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKV
DGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAK
FSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMH
LSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRAME-HDLBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRAME-HDLBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRAME-HDLBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource