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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRDM2-PEX14 (FusionGDB2 ID:68446)

Fusion Gene Summary for PRDM2-PEX14

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDM2-PEX14
Fusion gene ID: 68446
HgeneTgene
Gene symbol

PRDM2

PEX14

Gene ID

7799

5195

Gene namePR/SET domain 2peroxisomal biogenesis factor 14
SynonymsHUMHOXY1|KMT8|KMT8A|MTB-ZF|RIZ|RIZ1|RIZ2NAPP2|PBD13A|Pex14p|dJ734G22.2
Cytomap

1p36.21

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionPR domain zinc finger protein 2GATA-3 binding protein G3BMTE-binding proteinPR domain 2PR domain containing 2, with ZNF domainPR domain-containing protein 2lysine N-methyltransferase 8retinoblastoma protein-binding zinc finger proteinretinoblastomperoxisomal membrane protein PEX14NF-E2 associated polypeptide 2PTS1 receptor docking proteinperoxin-14peroxisomal membrane anchor protein PEX14peroxisomal membrane anchor protein Pex14p
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000502727, ENST00000235372, 
ENST00000311066, ENST00000376048, 
ENST00000343137, ENST00000413440, 
ENST00000503842, ENST00000505823, 
ENST00000356607, ENST00000538836, 
ENST00000492696, 
Fusion gene scores* DoF score8 X 4 X 5=16013 X 10 X 7=910
# samples 713
** MAII scorelog2(7/160*10)=-1.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRDM2 [Title/Abstract] AND PEX14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRDM2(14075982)-PEX14(10659294), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRDM2

GO:0045944

positive regulation of transcription by RNA polymerase II

8654390

TgenePEX14

GO:0016561

protein import into peroxisome matrix, translocation

21525035

TgenePEX14

GO:0032091

negative regulation of protein binding

21976670

TgenePEX14

GO:0034453

microtubule anchoring

21525035

TgenePEX14

GO:0036250

peroxisome transport along microtubule

21525035

TgenePEX14

GO:0043433

negative regulation of DNA-binding transcription factor activity

11863372

TgenePEX14

GO:0044721

protein import into peroxisome matrix, substrate release

21976670

TgenePEX14

GO:0045892

negative regulation of transcription, DNA-templated

11863372

TgenePEX14

GO:0065003

protein-containing complex assembly

21525035


check buttonFusion gene breakpoints across PRDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PEX14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A3BSPRDM2chr1

14075982

+PEX14chr1

10659294

+


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Fusion Gene ORF analysis for PRDM2-PEX14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000502727ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
3UTR-5UTRENST00000502727ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
3UTR-intronENST00000502727ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-5UTRENST00000235372ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-5UTRENST00000311066ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-5UTRENST00000376048ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-intronENST00000235372ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-intronENST00000311066ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5CDS-intronENST00000376048ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-3CDSENST00000343137ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-3CDSENST00000413440ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-3CDSENST00000503842ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-3CDSENST00000505823ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-5UTRENST00000343137ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-5UTRENST00000413440ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-5UTRENST00000503842ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-5UTRENST00000505823ENST00000538836PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-intronENST00000343137ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-intronENST00000413440ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-intronENST00000503842ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
5UTR-intronENST00000505823ENST00000492696PRDM2chr1

14075982

+PEX14chr1

10659294

+
In-frameENST00000235372ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
In-frameENST00000311066ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+
In-frameENST00000376048ENST00000356607PRDM2chr1

14075982

+PEX14chr1

10659294

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376048PRDM2chr114075982+ENST00000356607PEX14chr110659294+23736371201601493
ENST00000311066PRDM2chr114075982+ENST00000356607PEX14chr110659294+310313678502331493
ENST00000235372PRDM2chr114075982+ENST00000356607PEX14chr110659294+310313678502331493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376048ENST00000356607PRDM2chr114075982+PEX14chr110659294+0.0048753620.99512464
ENST00000311066ENST00000356607PRDM2chr114075982+PEX14chr110659294+0.0020384270.99796164
ENST00000235372ENST00000356607PRDM2chr114075982+PEX14chr110659294+0.0020384270.99796164

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Fusion Genomic Features for PRDM2-PEX14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRDM2chr114075982+PEX14chr110659294+9.35E-070.99999905
PRDM2chr114075982+PEX14chr110659294+9.35E-070.99999905

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRDM2-PEX14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:14075982/chr1:10659294)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+61028_1411702095.6666666666665DomainSET
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+6928_1411701683.0DomainSET
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+6828_141170227.0DomainSET

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101052_10741702095.6666666666665Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101361_14471702095.6666666666665Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610268_2961702095.6666666666665Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610933_10491702095.6666666666665Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691052_10741701683.0Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691361_14471701683.0Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69268_2961701683.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69933_10491701683.0Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681052_1074170227.0Compositional biasNote=Poly-Ser
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681361_1447170227.0Compositional biasNote=Arg/Lys-rich (basic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68268_296170227.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68933_1049170227.0Compositional biasNote=Pro-rich
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101028_10521702095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610970_9791702095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610985_9981702095.6666666666665MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691028_10521701683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69970_9791701683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69985_9981701683.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681028_1052170227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68970_979170227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68985_998170227.0MotifSH3-binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610294_3161702095.6666666666665RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69294_3161701683.0RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68294_316170227.0RegionNote=Retinoblastoma protein binding
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101134_11561702095.6666666666665Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101162_11851702095.6666666666665Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101191_12141702095.6666666666665Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101333_13551702095.6666666666665Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+6101455_14781702095.6666666666665Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610360_3821702095.6666666666665Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610390_4121702095.6666666666665Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:10659294ENST00000235372+610483_5061702095.6666666666665Zinc fingerC2H2-type 3
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691134_11561701683.0Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691162_11851701683.0Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691191_12141701683.0Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691333_13551701683.0Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+691455_14781701683.0Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69360_3821701683.0Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69390_4121701683.0Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:10659294ENST00000311066+69483_5061701683.0Zinc fingerC2H2-type 3
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681134_1156170227.0Zinc fingerC2H2-type 4
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681162_1185170227.0Zinc fingerC2H2-type 5
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681191_1214170227.0Zinc fingerC2H2-type 6
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681333_1355170227.0Zinc fingerC2H2-type 7%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+681455_1478170227.0Zinc fingerC2H2-type 8%3B atypical
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68360_382170227.0Zinc fingerC2H2-type 1
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68390_412170227.0Zinc fingerC2H2-type 2
HgenePRDM2chr1:14075982chr1:10659294ENST00000376048+68483_506170227.0Zinc fingerC2H2-type 3


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Fusion Gene Sequence for PRDM2-PEX14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68446_68446_1_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000235372_PEX14_chr1_10659294_ENST00000356607_length(transcript)=3103nt_BP=1367nt
GTAAAAGTGACATTCTAAATGTTCCTCACTCTGCGAGGCTTATTTTTTAGGGACTTTGCTATAATTCTGAAAGACTTAGTTTTACAGTAC
ATCTGAAAGTAGGAGTTTTCAGAAGTATGGCTCTTGGGATAAATTTAGATTCTTAATTGTGAAGCTCTGTTACCACTTGTTAGAAGGCAG
GTCAGCTCACCTGCTTGGGGAGGTAAATATATGAATGCACTCTCGAGTAATTTAATGGAGCCCTACCTCAATGTACAGAATGACAGTATC
ACAGATCAAGAATGGAGTACGAGTGATTTTCGGCTATGGTGGGGGTAGGTAGGTCACTTGTCCCCTGTTGTCTCTTACTATTTGTAAAGT
GAAGACTATGATTAGTCTTTTTGATCGGGATGGTTTGAGATGAATAAAGAATAGGCAGGCAATTTGGATACTTTAGGCTTTTCAAGAACA
TTAGTAACATTTTTTCTTAGATATTTCTCCTAATACAATGAGTGTTGTGAAATAACATGGCAGTTATTGTTGAGAGAAAAGCCTTCCCAG
TTATGTATTGAGTCCTTAGGCGTTTTGACCTTCCCTCCACTCTTACAGAACTTGGTGGAAGGGGCCACTATGTTTTCTACCTCCTTCCGT
GCCTTTCACAAAGCCACATCCTGCACCGTCTACCCTTCTCTGTGGATATTTTTCCGCTTGGCAATTTCCTTTCCTGAGGCACCCACTTGG
GACATCTGAATCTCCATCTCCATGTTGATGGCCCGTTTGTGCTTGGACGTGTTCTTCCACTTGAGACTGAGGGTTCATGTAATCAAAGAA
GTTTCTTTGTTGTGTGTATCTTTACAGAACACAACAGGAATTGAAAATGAATCAGAACACTACTGAGCCTGTGGCGGCCACCGAGACCCT
GGCTGAGGTACCCGAACATGTGCTGCGAGGACTTCCGGAGGAAGTGAGGCTTTTCCCTTCTGCTGTTGACAAGACCCGGATTGGTGTCTG
GGCCACTAAACCAATTTTAAAAGGCAAAAAATTTGGGCCATTTGTTGGTGATAAGAAAAAAAGATCTCAGGTTAAGAATAATGTATACAT
GTGGGAGGTGTATTACCCAAATTTGGGATGGATGTGCATTGATGCCACTGATCCAGAGAAGGGAAACTGGCTGCGATATGTGAATTGGGC
TTGCTCAGGAGAAGAGCAAAATTTATTCCCACTGGAAATCAACAGAGCCATTTACTATAAAACTTTAAAGCCAATCGCGCCGGGCGAGGA
GCTCCTGGTCTGGTACAATGGGGAAGACAACCCTGAGATAGCAGCTGCGATTGAGGAAGAGCGAGCCAGCGCCCGGAGCAAGCGGAGCTC
CCCCAAGAGCCGGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGG
CCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGC
CCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGA
CAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGC
CTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAA
CTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCC
ATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAG
CAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCA
CTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGA
GGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCG
GGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGC
CTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGA
GCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCG
CCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCG
GGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGC
ATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCC
TGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTG
CGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGG
GCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGAACGGAAGATA

>68446_68446_1_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000235372_PEX14_chr1_10659294_ENST00000356607_length(amino acids)=493AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGLTDEEID
MAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSE
LSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIP
VKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDV

--------------------------------------------------------------
>68446_68446_2_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000311066_PEX14_chr1_10659294_ENST00000356607_length(transcript)=3103nt_BP=1367nt
GTAAAAGTGACATTCTAAATGTTCCTCACTCTGCGAGGCTTATTTTTTAGGGACTTTGCTATAATTCTGAAAGACTTAGTTTTACAGTAC
ATCTGAAAGTAGGAGTTTTCAGAAGTATGGCTCTTGGGATAAATTTAGATTCTTAATTGTGAAGCTCTGTTACCACTTGTTAGAAGGCAG
GTCAGCTCACCTGCTTGGGGAGGTAAATATATGAATGCACTCTCGAGTAATTTAATGGAGCCCTACCTCAATGTACAGAATGACAGTATC
ACAGATCAAGAATGGAGTACGAGTGATTTTCGGCTATGGTGGGGGTAGGTAGGTCACTTGTCCCCTGTTGTCTCTTACTATTTGTAAAGT
GAAGACTATGATTAGTCTTTTTGATCGGGATGGTTTGAGATGAATAAAGAATAGGCAGGCAATTTGGATACTTTAGGCTTTTCAAGAACA
TTAGTAACATTTTTTCTTAGATATTTCTCCTAATACAATGAGTGTTGTGAAATAACATGGCAGTTATTGTTGAGAGAAAAGCCTTCCCAG
TTATGTATTGAGTCCTTAGGCGTTTTGACCTTCCCTCCACTCTTACAGAACTTGGTGGAAGGGGCCACTATGTTTTCTACCTCCTTCCGT
GCCTTTCACAAAGCCACATCCTGCACCGTCTACCCTTCTCTGTGGATATTTTTCCGCTTGGCAATTTCCTTTCCTGAGGCACCCACTTGG
GACATCTGAATCTCCATCTCCATGTTGATGGCCCGTTTGTGCTTGGACGTGTTCTTCCACTTGAGACTGAGGGTTCATGTAATCAAAGAA
GTTTCTTTGTTGTGTGTATCTTTACAGAACACAACAGGAATTGAAAATGAATCAGAACACTACTGAGCCTGTGGCGGCCACCGAGACCCT
GGCTGAGGTACCCGAACATGTGCTGCGAGGACTTCCGGAGGAAGTGAGGCTTTTCCCTTCTGCTGTTGACAAGACCCGGATTGGTGTCTG
GGCCACTAAACCAATTTTAAAAGGCAAAAAATTTGGGCCATTTGTTGGTGATAAGAAAAAAAGATCTCAGGTTAAGAATAATGTATACAT
GTGGGAGGTGTATTACCCAAATTTGGGATGGATGTGCATTGATGCCACTGATCCAGAGAAGGGAAACTGGCTGCGATATGTGAATTGGGC
TTGCTCAGGAGAAGAGCAAAATTTATTCCCACTGGAAATCAACAGAGCCATTTACTATAAAACTTTAAAGCCAATCGCGCCGGGCGAGGA
GCTCCTGGTCTGGTACAATGGGGAAGACAACCCTGAGATAGCAGCTGCGATTGAGGAAGAGCGAGCCAGCGCCCGGAGCAAGCGGAGCTC
CCCCAAGAGCCGGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGG
CCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGC
CCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGA
CAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGC
CTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAA
CTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCC
ATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAG
CAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCA
CTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGA
GGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCG
GGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGC
CTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGA
GCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCG
CCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCG
GGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGC
ATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCC
TGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTG
CGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGG
GCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGAACGGAAGATA

>68446_68446_2_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000311066_PEX14_chr1_10659294_ENST00000356607_length(amino acids)=493AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGLTDEEID
MAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSE
LSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIP
VKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDV

--------------------------------------------------------------
>68446_68446_3_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000376048_PEX14_chr1_10659294_ENST00000356607_length(transcript)=2373nt_BP=637nt
GCGAAACAGCGGCGGCGGCGGCGGCCCTCGGTGCTCTGAGGCGCTGGCGCGGCGGGCGCGGGGTTCATGTAATCAAAGAAGTTTCTTTGT
TGTGTGTATCTTTACAGAACACAACAGGAATTGAAAATGAATCAGAACACTACTGAGCCTGTGGCGGCCACCGAGACCCTGGCTGAGGTA
CCCGAACATGTGCTGCGAGGACTTCCGGAGGAAGTGAGGCTTTTCCCTTCTGCTGTTGACAAGACCCGGATTGGTGTCTGGGCCACTAAA
CCAATTTTAAAAGGCAAAAAATTTGGGCCATTTGTTGGTGATAAGAAAAAAAGATCTCAGGTTAAGAATAATGTATACATGTGGGAGGTG
TATTACCCAAATTTGGGATGGATGTGCATTGATGCCACTGATCCAGAGAAGGGAAACTGGCTGCGATATGTGAATTGGGCTTGCTCAGGA
GAAGAGCAAAATTTATTCCCACTGGAAATCAACAGAGCCATTTACTATAAAACTTTAAAGCCAATCGCGCCGGGCGAGGAGCTCCTGGTC
TGGTACAATGGGGAAGACAACCCTGAGATAGCAGCTGCGATTGAGGAAGAGCGAGCCAGCGCCCGGAGCAAGCGGAGCTCCCCCAAGAGC
CGGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGGCCCAGCCACA
CAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGCCCTGGCCATC
ATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGACAGAAAGCAG
CTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGCCTCCGTCCAG
GAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAACTGGATCCTG
GAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCCATCCCCATCA
GCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAGCAGCGACATC
TCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCACTTGCTGGGC
CCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGAGGACAAGGAG
GACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCGGGGCGGGGAT
GGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGCCTGCTGCCTC
CAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGAGCCCAGGTAG
GGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCGCCTGGCCGCC
AGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCGGGGCCCAAGC
CCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGCATGGCCAGAG
CTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCCTGGGCCCGGC
CCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTGCGCTTCCGAT
GCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGGGCCTTCCTGA
CCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGAACGGAAGATAGGACTGTATA

>68446_68446_3_PRDM2-PEX14_PRDM2_chr1_14075982_ENST00000376048_PEX14_chr1_10659294_ENST00000356607_length(amino acids)=493AA_BP=172
MKMNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCI
DATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGLTDEEID
MAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSE
LSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIP
VKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRDM2-PEX14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRDM2-PEX14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRDM2-PEX14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource