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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRDM6-NIPAL4 (FusionGDB2 ID:68453)

Fusion Gene Summary for PRDM6-NIPAL4

Fusion gene summary

Fusion gene information	Fusion gene name: PRDM6-NIPAL4
	Fusion gene ID: 68453
		Hgene	Tgene
	Gene symbol	PRDM6	NIPAL4
	Gene ID	93166	348938
	Gene name	PR/SET domain 6	NIPA like domain containing 4
	Synonyms	KMT8C\|PDA3\|PRISM	ARCI6\|ICHTHYIN\|ICHYN
	Cytomap	5q23.2	5q33.3
	Type of gene	protein-coding	protein-coding
	Description	putative histone-lysine N-methyltransferase PRDM6PR domain 6PR domain containing 6PR domain-containing protein 6PR-domain zinc finger protein 6	magnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000407847, ENST00000464424,	ENST00000521390, ENST00000311946, ENST00000435489,
Fusion gene scores	* DoF score	1 X 1 X 1=1	2 X 1 X 1=2
	# samples	1	1
	** MAII score	log2(1/1*10)=3.32192809488736	log2(1/2*10)=2.32192809488736
Context	PubMed: PRDM6 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRDM6(122495332)-NIPAL4(156890102), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PRDM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NIPAL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-BP-4986-01A	PRDM6	chr5	122495332	-	NIPAL4	chr5	156890102	+
ChimerDB4	KIRC	TCGA-BP-4986-01A	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+

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Fusion Gene ORF analysis for PRDM6-NIPAL4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000407847	ENST00000521390	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+
In-frame	ENST00000407847	ENST00000311946	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+
In-frame	ENST00000407847	ENST00000435489	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+
intron-3CDS	ENST00000464424	ENST00000311946	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+
intron-3CDS	ENST00000464424	ENST00000435489	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+
intron-3UTR	ENST00000464424	ENST00000521390	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000407847

PRDM6

chr5

122495332

ENST00000435489

NIPAL4

chr5

156890102

2828

1567

246

2687

813

ENST00000407847

PRDM6

chr5

122495332

ENST00000311946

NIPAL4

chr5

156890102

4502

1567

246

2744

832

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000407847	ENST00000435489	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+	0.013964874	0.9860351
ENST00000407847	ENST00000311946	PRDM6	chr5	122495332	+	NIPAL4	chr5	156890102	+	0.009352864	0.99064714

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Fusion Genomic Features for PRDM6-NIPAL4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PRDM6	chr5	122495332	+	NIPAL4	chr5	156890101	+	0.000113844	0.99988616
PRDM6	chr5	122495332	+	NIPAL4	chr5	156890101	+	0.000113844	0.99988616

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRDM6-NIPAL4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:122495332/chr5:156890102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

123_129

384

596.0

Compositional bias

Note=Poly-Ala

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

151_162

384

596.0

Compositional bias

Note=Poly-Gly

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

228_232

384

596.0

Compositional bias

Note=Poly-Ala

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

47_73

384

596.0

Compositional bias

Note=Pro-rich

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

97_106

384

596.0

Compositional bias

Note=Poly-Ala

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

246_365

384

596.0

Domain

SET

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

139_164

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

186_186

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

208_215

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

237_257

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

279_285

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

307_323

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

345_355

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

377_386

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

408_466

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

139_164

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

186_186

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

208_215

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

237_257

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

279_285

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

307_323

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

345_355

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

377_386

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

408_466

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

118_138

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

165_185

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

187_207

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

216_236

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

258_278

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

286_306

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

324_344

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

356_376

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

387_407

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

118_138

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

165_185

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

187_207

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

216_236

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

258_278

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

286_306

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

324_344

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

356_376

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

387_407

448.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

473_495

384

596.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

501_523

384

596.0

Zinc finger

C2H2-type 2

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

529_551

384

596.0

Zinc finger

C2H2-type 3

Hgene

PRDM6

chr5:122495332

chr5:156890102

ENST00000407847

557_579

384

596.0

Zinc finger

C2H2-type 4%3B degenerate

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000311946

1_117

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:122495332

chr5:156890102

ENST00000435489

1_117

448.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for PRDM6-NIPAL4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68453_68453_1_PRDM6-NIPAL4_PRDM6_chr5_122495332_ENST00000407847_NIPAL4_chr5_156890102_ENST00000311946_length(transcript)=4502nt_BP=1567nt
CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT
CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC
GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC
GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA
GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC
CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT
CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG
CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC
GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG
CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC
GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC
AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT
GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC
AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG
CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT
GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC
AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT
GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC
AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG
GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT
CGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTT
GGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTG
AGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAG
AAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATC
CTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCT
GCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATC
CTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTG
TTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCG
GGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAA
AACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACC
TCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCT
GCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCAT
CACTGTTTCCAGGAGAAAAATCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTAC
ATCAGTGCCTGCAGGTTCCCTGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCC
ACTGAATGTAGCACAGTCCAAGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCG
TTGTTGTTGTTGTTGTTGTTTTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCC
AGAGCTGACAGGGACACAACCAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTC
TTACTGTGAAAGCCACTTGATGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATC
CACCCAGTCCATCCCACCATCACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACT
GGAAACAAAACAATAATAGAGCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAAT
TCACTGCTTCAAAGTGGCCTGGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGG
GGAGGTGGGAAGAGGATGAGGAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGA
CTCTGGTGCTCATCTGGGAACTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCA
ATGGCCAACTGGAGGTGCAGACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGC
CCACACTGGGAAGCAGCATGCCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATAC
AAAAAACCAGAGCAGCTGGAGAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAG
AACCATTAGAAAGGGAAATTAGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCT
GTGTGACTCTACCTGCACTCTGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGT
TTGGCTGACCAGCAGACTGGCTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAA
TGCAACAAGTTGGCTCTTGAGAATGGCAGTAAACTGAGGGCCCTAAGAGTGTGGTCTGCAGGGTCAAGAATAAAGATTACAGATTATATT

>68453_68453_1_PRDM6-NIPAL4_PRDM6_chr5_122495332_ENST00000407847_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=832AA_BP=441
MQVGRFPGGTISRTLLPRCSGACSARRAHTLAHPHAHRDTRTHPPAAPSFQFEAPDMLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGP
LKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAA
AAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHG
PLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQ
DGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSS
QEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTM
AAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAV
LLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTS
LVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLV

--------------------------------------------------------------
>68453_68453_2_PRDM6-NIPAL4_PRDM6_chr5_122495332_ENST00000407847_NIPAL4_chr5_156890102_ENST00000435489_length(transcript)=2828nt_BP=1567nt
CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT
CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC
GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC
GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA
GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC
CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT
CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG
CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC
GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG
CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC
GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC
AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT
GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC
AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG
CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT
GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC
AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT
GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC
AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG
GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT
CGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTC
CTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGC
ACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTG
TTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATC
ATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTC
CGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTC
AACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGC
ATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGAC
ATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAAC
GTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATAT
GTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGC

>68453_68453_2_PRDM6-NIPAL4_PRDM6_chr5_122495332_ENST00000407847_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=813AA_BP=441
MQVGRFPGGTISRTLLPRCSGACSARRAHTLAHPHAHRDTRTHPPAAPSFQFEAPDMLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGP
LKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAA
AAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHG
PLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQ
DGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSS
QEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAYAFAPATVV
TPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQ
RNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSI
ILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFI

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Top

Fusion Gene PPI Analysis for PRDM6-NIPAL4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PRDM6-NIPAL4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PRDM6-NIPAL4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source