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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRIM2-CASS4 (FusionGDB2 ID:68589)

Fusion Gene Summary for PRIM2-CASS4

check button Fusion gene summary
Fusion gene informationFusion gene name: PRIM2-CASS4
Fusion gene ID: 68589
HgeneTgene
Gene symbol

PRIM2

CASS4

Gene ID

5558

57091

Gene nameDNA primase subunit 2Cas scaffold protein family member 4
SynonymsPRIM2A|p58C20orf32|CAS4|HEFL|HEPL
Cytomap

6p11.2

20q13.31

Type of geneprotein-codingprotein-coding
DescriptionDNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa)cas scaffolding protein family member 4HEF-like proteinHEF1-EFS-p130Cas-like protein
Modification date2020031320200313
UniProtAcc.

Q9NQ75

Ensembl transtripts involved in fusion geneENST00000389488, ENST00000607273, 
ENST00000360314, ENST00000371336, 
ENST00000434344, 
Fusion gene scores* DoF score9 X 6 X 6=3247 X 5 X 4=140
# samples 108
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRIM2 [Title/Abstract] AND CASS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRIM2(57398317)-CASS4(55012220), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASS4

GO:0061098

positive regulation of protein tyrosine kinase activity

18256281


check buttonFusion gene breakpoints across PRIM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RH-01APRIM2chr6

57398317

+CASS4chr20

55012220

+


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Fusion Gene ORF analysis for PRIM2-CASS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000389488ENST00000360314PRIM2chr6

57398317

+CASS4chr20

55012220

+
3UTR-3CDSENST00000389488ENST00000371336PRIM2chr6

57398317

+CASS4chr20

55012220

+
3UTR-3CDSENST00000389488ENST00000434344PRIM2chr6

57398317

+CASS4chr20

55012220

+
In-frameENST00000607273ENST00000360314PRIM2chr6

57398317

+CASS4chr20

55012220

+
In-frameENST00000607273ENST00000371336PRIM2chr6

57398317

+CASS4chr20

55012220

+
In-frameENST00000607273ENST00000434344PRIM2chr6

57398317

+CASS4chr20

55012220

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000607273PRIM2chr657398317+ENST00000360314CASS4chr2055012220+346511074834311127
ENST00000607273PRIM2chr657398317+ENST00000371336CASS4chr2055012220+402511074834311127
ENST00000607273PRIM2chr657398317+ENST00000434344CASS4chr2055012220+27131107482120690

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000607273ENST00000360314PRIM2chr657398317+CASS4chr2055012220+0.0022801790.9977198
ENST00000607273ENST00000371336PRIM2chr657398317+CASS4chr2055012220+0.0016487050.99835134
ENST00000607273ENST00000434344PRIM2chr657398317+CASS4chr2055012220+0.0041569350.9958431

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Fusion Genomic Features for PRIM2-CASS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRIM2chr657398317+CASS4chr2055012219+4.78E-081
PRIM2chr657398317+CASS4chr2055012219+4.78E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRIM2-CASS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:57398317/chr20:55012220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CASS4

Q9NQ75

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASS4chr6:57398317chr20:55012220ENST0000036031417274_27712787.0Compositional biasNote=Poly-Ser
TgeneCASS4chr6:57398317chr20:55012220ENST0000036031417373_42912787.0Compositional biasNote=Ser-rich
TgeneCASS4chr6:57398317chr20:55012220ENST0000037133606274_27712787.0Compositional biasNote=Poly-Ser
TgeneCASS4chr6:57398317chr20:55012220ENST0000037133606373_42912787.0Compositional biasNote=Ser-rich
TgeneCASS4chr6:57398317chr20:55012220ENST0000043434405274_27712350.0Compositional biasNote=Poly-Ser
TgeneCASS4chr6:57398317chr20:55012220ENST0000043434405373_42912350.0Compositional biasNote=Ser-rich
TgeneCASS4chr6:57398317chr20:55012220ENST000003603141711_7312787.0DomainSH3
TgeneCASS4chr6:57398317chr20:55012220ENST000003713360611_7312787.0DomainSH3
TgeneCASS4chr6:57398317chr20:55012220ENST000004343440511_7312350.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PRIM2-CASS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68589_68589_1_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000360314_length(transcript)=3465nt_BP=1107nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCATTAACAGCCAGGTCCTTGCCTGCTGTGCAG
TCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCATTCCTACACTAGCCAAGATTACAGTACCCAGGGAAATGTTGGGAAGATT
TCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCACTTTACATGCATCAGTTACATAAAGCCTTGCGGGAAAATCACCATCTT
TGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGCATTGGTTTAACTTTGGAACAGACATTGCAGTTCTGGAAGCAAGAATTT
ATCAAAGGAAAGATGGATCCAGACAAGGCACTCCTGGCCAGGGCACTTTATGACAACTGCCCTGACTGCTCTGACGAGCTGGCTTTCAGC
AGAGGGGACATCCTGACCATTCTGGAGCAACACGTGCCAGAAAGCGAGGGTTGGTGGAAGTGTTTGCTCCATGGGAGGCAAGGCCTGGCC
CCTGCCAACCGCCTCCAAATCCTCACGGAGGTCGCTGCAGACAGGCCGTGCCCCCCATTCCTGAGAGGCCTGGAAGAAGCTCCTGCCAGC
TCAGAGGAGACCTATCAGGTGCCCACTCTACCCCGCCCTCCCACTCCAGGCCCCGTTTATGAGCAGATGAGGAGTTGGGCGGAGGGGCCC
CAGCCCCCTACTGCCCAAGTCTATGAATTCCCCGACCCTCCCACCAGTGCCAGAATCATCTGTGAAAAGACTCTCAGCTTTCCAAAACAG
GCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCC
GTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCA
AGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTACCAAATCCTCAGAAATCGGAATGGATT
TATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGGAAGAATCAAGGCCCCACGCTCTCCCC
AGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGAATAACAATGTGCCCATGCAGAAAAAA
CTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATGAAGATGTCAGCTACAAGGTTCCTTCA
AGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGG
AAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCTCCAGACGGACAACTTCCCCATCTCCT
GAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCACCACATCCACCGACGACTCCTCCAGC
TCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGATGGCTCTGCAGCACAAGGTGGTCAGC
TCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCAACATTGATGCAATCCACAGGTCCACT
GATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCTGTAACCTCACTGACAGTAACCTTCAG
AACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGGAAAGCTTGGATAATCGCAATTGGCCT
CTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGGTGGCACGGATGCTTCCAGAAGACATC
AAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGGAAGAGACTGTGCAGTTGACCCCAAAT
GCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGAGTACCCCTTCCACTAAGCAAAGGGAA
GATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAA
CAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGC
CTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAG
ACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAAT
GCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGG

>68589_68589_1_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000360314_length(amino acids)=1127AA_BP=353
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSY
TSQDYSTQGNVGKISLDQIDLLSTKSFPLYMHQLHKALRENHHLCHGGRMQYVLFLKGIGLTLEQTLQFWKQEFIKGKMDPDKALLARAL
YDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTP
GPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARIICEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPA
SPKKAGLHPPDSQASGQGVPLISVTTLRRGGYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRS
LTPQLNNNVPMQKKLSLPEIPSYGFLVPRGTFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGH
NSSWFSRRTTSPSPEPDRLSGSSSDSRASIVSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFR
DYLEANIDAIHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDL
ERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANIC
GQNPGPLIPQPSSQQTPERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSH

--------------------------------------------------------------
>68589_68589_2_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000371336_length(transcript)=4025nt_BP=1107nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCATTAACAGCCAGGTCCTTGCCTGCTGTGCAG
TCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCATTCCTACACTAGCCAAGATTACAGTACCCAGGGAAATGTTGGGAAGATT
TCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCACTTTACATGCATCAGTTACATAAAGCCTTGCGGGAAAATCACCATCTT
TGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGCATTGGTTTAACTTTGGAACAGACATTGCAGTTCTGGAAGCAAGAATTT
ATCAAAGGAAAGATGGATCCAGACAAGGCACTCCTGGCCAGGGCACTTTATGACAACTGCCCTGACTGCTCTGACGAGCTGGCTTTCAGC
AGAGGGGACATCCTGACCATTCTGGAGCAACACGTGCCAGAAAGCGAGGGTTGGTGGAAGTGTTTGCTCCATGGGAGGCAAGGCCTGGCC
CCTGCCAACCGCCTCCAAATCCTCACGGAGGTCGCTGCAGACAGGCCGTGCCCCCCATTCCTGAGAGGCCTGGAAGAAGCTCCTGCCAGC
TCAGAGGAGACCTATCAGGTGCCCACTCTACCCCGCCCTCCCACTCCAGGCCCCGTTTATGAGCAGATGAGGAGTTGGGCGGAGGGGCCC
CAGCCCCCTACTGCCCAAGTCTATGAATTCCCCGACCCTCCCACCAGTGCCAGAATCATCTGTGAAAAGACTCTCAGCTTTCCAAAACAG
GCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCC
GTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCA
AGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTACCAAATCCTCAGAAATCGGAATGGATT
TATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGGAAGAATCAAGGCCCCACGCTCTCCCC
AGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGAATAACAATGTGCCCATGCAGAAAAAA
CTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATGAAGATGTCAGCTACAAGGTTCCTTCA
AGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGG
AAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCTCCAGACGGACAACTTCCCCATCTCCT
GAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCACCACATCCACCGACGACTCCTCCAGC
TCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGATGGCTCTGCAGCACAAGGTGGTCAGC
TCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCAACATTGATGCAATCCACAGGTCCACT
GATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCTGTAACCTCACTGACAGTAACCTTCAG
AACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGGAAAGCTTGGATAATCGCAATTGGCCT
CTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGGTGGCACGGATGCTTCCAGAAGACATC
AAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGGAAGAGACTGTGCAGTTGACCCCAAAT
GCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGAGTACCCCTTCCACTAAGCAAAGGGAA
GATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAA
CAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGC
CTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAG
ACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAAT
GCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGG
ACACTGGGATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCACACCCACAACTTGTGCAACTCTGCCCTATGGGAA
AAGCCAGCCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTAGTACCAAGTGGCTAAGCAACCCCAGGGCATTGA
CTTACCCCGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAGTTTAGCATATATGGAGTATGCAGTATCAGCTTG
AAGTGACTTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTGTTTTTTGAGACAAAGTCTCACTCTGTCACACAG
GCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAGCAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGG
TACTACAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAGGTCTCACATATTTATTACTGAACCCAGCCAACC

>68589_68589_2_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000371336_length(amino acids)=1127AA_BP=353
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSY
TSQDYSTQGNVGKISLDQIDLLSTKSFPLYMHQLHKALRENHHLCHGGRMQYVLFLKGIGLTLEQTLQFWKQEFIKGKMDPDKALLARAL
YDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTP
GPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARIICEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPA
SPKKAGLHPPDSQASGQGVPLISVTTLRRGGYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRS
LTPQLNNNVPMQKKLSLPEIPSYGFLVPRGTFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGH
NSSWFSRRTTSPSPEPDRLSGSSSDSRASIVSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFR
DYLEANIDAIHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDL
ERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANIC
GQNPGPLIPQPSSQQTPERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSH

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>68589_68589_3_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000434344_length(transcript)=2713nt_BP=1107nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCATTAACAGCCAGGTCCTTGCCTGCTGTGCAG
TCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCATTCCTACACTAGCCAAGATTACAGTACCCAGGGAAATGTTGGGAAGATT
TCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCACTTTACATGCATCAGTTACATAAAGCCTTGCGGGAAAATCACCATCTT
TGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGCATTGGTTTAACTTTGGAACAGACATTGCAGTTCTGGAAGCAAGAATTT
ATCAAAGGAAAGATGGATCCAGACAAGGCACTCCTGGCCAGGGCACTTTATGACAACTGCCCTGACTGCTCTGACGAGCTGGCTTTCAGC
AGAGGGGACATCCTGACCATTCTGGAGCAACACGTGCCAGAAAGCGAGGGTTGGTGGAAGTGTTTGCTCCATGGGAGGCAAGGCCTGGCC
CCTGCCAACCGCCTCCAAATCCTCACGGAGGTCGCTGCAGACAGGCCGTGCCCCCCATTCCTGAGAGGCCTGGAAGAAGCTCCTGCCAGC
TCAGAGGAGACCTATCAGGTGCCCACTCTACCCCGCCCTCCCACTCCAGGCCCCGTTTATGAGCAGATGAGGAGTTGGGCGGAGGGGCCC
CAGCCCCCTACTGCCCAAGTCTATGAATTCCCCGACCCTCCCACCAGTGCCAGAATCATCTGTGAAAAGACTCTCAGCTTTCCAAAACAG
GCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCC
GTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCA
AGTAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTT
GGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATC
ATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTC
TGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAG
GCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAG
CTTCACACCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAG
CTGGTAGTACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTT
GTGAAGTTTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTT
TGTTTGTTTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGG
TTGAAGCAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAA
TGAAAGGTCTCACATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGATTCAGAAAGAAAAAATATATTCCCAATAAAACAT

>68589_68589_3_PRIM2-CASS4_PRIM2_chr6_57398317_ENST00000607273_CASS4_chr20_55012220_ENST00000434344_length(amino acids)=690AA_BP=353
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSY
TSQDYSTQGNVGKISLDQIDLLSTKSFPLYMHQLHKALRENHHLCHGGRMQYVLFLKGIGLTLEQTLQFWKQEFIKGKMDPDKALLARAL
YDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTP
GPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARIICEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPA
SPKKAGLHPPDSQASNPGPLIPQPSSQQTPERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQE

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Fusion Gene PPI Analysis for PRIM2-CASS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRIM2-CASS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRIM2-CASS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource