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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRIM2-COL21A1 (FusionGDB2 ID:68590)

Fusion Gene Summary for PRIM2-COL21A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRIM2-COL21A1
Fusion gene ID: 68590
HgeneTgene
Gene symbol

PRIM2

COL21A1

Gene ID

5558

81578

Gene nameDNA primase subunit 2collagen type XXI alpha 1 chain
SynonymsPRIM2A|p58COLA1L|FP633
Cytomap

6p11.2

6p12.1|6p12.3-p11.2

Type of geneprotein-codingprotein-coding
DescriptionDNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa)collagen alpha-1(XXI) chainalpha 1 chain-like collagencollagen, type XXI, alpha 1
Modification date2020031320200320
UniProtAcc.

Q96P44

Ensembl transtripts involved in fusion geneENST00000389488, ENST00000607273, 
ENST00000244728, ENST00000370808, 
ENST00000370819, ENST00000535941, 
ENST00000467045, 
Fusion gene scores* DoF score9 X 6 X 6=3248 X 7 X 6=336
# samples 1010
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRIM2 [Title/Abstract] AND COL21A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRIM2(57246966)-COL21A1(55929420), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PRIM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL21A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0BL-01APRIM2chr6

57246966

+COL21A1chr6

55929420

-
ChimerDB4BRCATCGA-BH-A0BLPRIM2chr6

57246966

+COL21A1chr6

55929420

-


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Fusion Gene ORF analysis for PRIM2-COL21A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000389488ENST00000244728PRIM2chr6

57246966

+COL21A1chr6

55929420

-
3UTR-3CDSENST00000389488ENST00000370808PRIM2chr6

57246966

+COL21A1chr6

55929420

-
3UTR-3CDSENST00000389488ENST00000370819PRIM2chr6

57246966

+COL21A1chr6

55929420

-
3UTR-3CDSENST00000389488ENST00000535941PRIM2chr6

57246966

+COL21A1chr6

55929420

-
3UTR-5UTRENST00000389488ENST00000467045PRIM2chr6

57246966

+COL21A1chr6

55929420

-
5CDS-5UTRENST00000607273ENST00000467045PRIM2chr6

57246966

+COL21A1chr6

55929420

-
In-frameENST00000607273ENST00000244728PRIM2chr6

57246966

+COL21A1chr6

55929420

-
In-frameENST00000607273ENST00000370808PRIM2chr6

57246966

+COL21A1chr6

55929420

-
In-frameENST00000607273ENST00000370819PRIM2chr6

57246966

+COL21A1chr6

55929420

-
In-frameENST00000607273ENST00000535941PRIM2chr6

57246966

+COL21A1chr6

55929420

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000607273PRIM2chr657246966+ENST00000244728COL21A1chr655929420-2594780481526492
ENST00000607273PRIM2chr657246966+ENST00000370819COL21A1chr655929420-2594780481526492
ENST00000607273PRIM2chr657246966+ENST00000535941COL21A1chr655929420-2593780481526492
ENST00000607273PRIM2chr657246966+ENST00000370808COL21A1chr655929420-2491780481424458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000607273ENST00000244728PRIM2chr657246966+COL21A1chr655929420-0.0001523230.99984765
ENST00000607273ENST00000370819PRIM2chr657246966+COL21A1chr655929420-0.0001523230.99984765
ENST00000607273ENST00000535941PRIM2chr657246966+COL21A1chr655929420-0.0001512320.9998487
ENST00000607273ENST00000370808PRIM2chr657246966+COL21A1chr655929420-0.0001454530.99985456

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Fusion Genomic Features for PRIM2-COL21A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRIM2-COL21A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:57246966/chr6:55929420)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL21A1

Q96P44

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230734_787709958.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230825_882709958.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230884_934709958.0DomainNote=Collagen-like 7
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614230_412109324.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614448_500109324.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614501_542109324.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614543_594109324.0DomainNote=Collagen-like 3
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614681_733109324.0DomainNote=Collagen-like 4
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614734_787109324.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614825_882109324.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370808614884_934109324.0DomainNote=Collagen-like 7
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129734_787706955.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129825_882706955.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129884_934706955.0DomainNote=Collagen-like 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230230_412709958.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000244728223037_211709958.0DomainVWFA
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230448_500709958.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230501_542709958.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230543_594709958.0DomainNote=Collagen-like 3
TgeneCOL21A1chr6:57246966chr6:55929420ENST000002447282230681_733709958.0DomainNote=Collagen-like 4
TgeneCOL21A1chr6:57246966chr6:55929420ENST0000037080861437_211109324.0DomainVWFA
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129230_412706955.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:57246966chr6:55929420ENST00000370819212937_211706955.0DomainVWFA
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129448_500706955.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129501_542706955.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129543_594706955.0DomainNote=Collagen-like 3
TgeneCOL21A1chr6:57246966chr6:55929420ENST000003708192129681_733706955.0DomainNote=Collagen-like 4


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Fusion Gene Sequence for PRIM2-COL21A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68590_68590_1_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000244728_length(transcript)=2594nt_BP=780nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCAGGTCAAAAGGGAGAAAATGGAAGACAGGGA
ATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGA
TCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGT
TTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTT
CAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAG
GGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAA
GGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGC
CCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAA
CCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGT
CTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGA
AACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCA
TTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCC
ACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGT
CCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTG
ATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCG
GTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGA
GTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTG
GAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCC
ATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAAT
GTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATAT

>68590_68590_1_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000244728_length(amino acids)=492AA_BP=242
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALAGQKGENGRQGIPGQQGIQGHHGAKGE
RGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHG
SPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLP

--------------------------------------------------------------
>68590_68590_2_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000370808_length(transcript)=2491nt_BP=780nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCAGGTCAAAAGGGAGAAAATGGAAGACAGGGA
ATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGA
TCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGT
TTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGGCCCAGAGGGTCCCAGAGGA
TTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAAGGCCTACCAGGA
AGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGCCCTCCTGGAATA
AGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAACCAGGCCCCCCA
GGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGTCTGATGCCTCAT
TCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGAAACTTAAGTACC
TCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCATTTGGAGCCCTT
GGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCCACCATTGCCTGT
TAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGTCCATGTGACTTT
CATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTGATATTCACCTGG
GATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCGGTGTTGTGAATA
GCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGAGTATTAATTACT
TTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTGGAAGTACTAAAA
GACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCCATATATGTTAAT
TTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAATGTCTTGTTATTT
TTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATATTTCATCCTTGTC

>68590_68590_2_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000370808_length(amino acids)=458AA_BP=242
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALAGQKGENGRQGIPGQQGIQGHHGAKGE
RGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRGPEGPRGLPGLPGRDGVPGLVGV
PGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGPPGICDPSLCFSVIARRD

--------------------------------------------------------------
>68590_68590_3_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000370819_length(transcript)=2594nt_BP=780nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCAGGTCAAAAGGGAGAAAATGGAAGACAGGGA
ATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGA
TCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGT
TTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTT
CAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAG
GGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAA
GGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGC
CCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAA
CCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGT
CTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGA
AACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCA
TTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCC
ACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGT
CCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTG
ATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCG
GTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGA
GTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTG
GAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCC
ATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAAT
GTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATAT

>68590_68590_3_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000370819_length(amino acids)=492AA_BP=242
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALAGQKGENGRQGIPGQQGIQGHHGAKGE
RGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHG
SPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLP

--------------------------------------------------------------
>68590_68590_4_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000535941_length(transcript)=2593nt_BP=780nt
GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG
GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG
CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG
AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT
GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT
CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT
GAGGCTATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAG
TCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTT
AAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCAGGTCAAAAGGGAGAAAATGGAAGACAGGGA
ATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGA
TCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGT
TTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTT
CAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAG
GGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAA
GGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGC
CCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAA
CCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGT
CTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGA
AACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCA
TTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCC
ACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGT
CCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTG
ATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCG
GTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGA
GTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTG
GAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCC
ATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAAT
GTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATAT

>68590_68590_4_PRIM2-COL21A1_PRIM2_chr6_57246966_ENST00000607273_COL21A1_chr6_55929420_ENST00000535941_length(amino acids)=492AA_BP=242
MCFPEFEFLQVTKMEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESE
LRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIV
ASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALAGQKGENGRQGIPGQQGIQGHHGAKGE
RGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHG
SPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRIM2-COL21A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRIM2-COL21A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRIM2-COL21A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource