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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRKAG2-WASL (FusionGDB2 ID:68649)

Fusion Gene Summary for PRKAG2-WASL

Fusion gene summary

Fusion gene information	Fusion gene name: PRKAG2-WASL
	Fusion gene ID: 68649
		Hgene	Tgene
	Gene symbol	PRKAG2	WASL
	Gene ID	51422	8976
	Gene name	protein kinase AMP-activated non-catalytic subunit gamma 2	WASP like actin nucleation promoting factor
	Synonyms	AAKG\|AAKG2\|CMH6\|H91620p\|WPWS	N-WASP\|NWASP\|WASPB
	Cytomap	7q36.1	7q31.32
	Type of gene	protein-coding	protein-coding
	Description	5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunit	neural Wiskott-Aldrich syndrome proteinWiskott-Aldrich syndrome like
	Modification date	20200320	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000392801, ENST00000287878, ENST00000418337, ENST00000433631, ENST00000492843, ENST00000461529,	ENST00000223023,
Fusion gene scores	* DoF score	16 X 11 X 10=1760	6 X 5 X 6=180
	# samples	21	6
	** MAII score	log2(21/1760*10)=-3.06711419585854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PRKAG2 [Title/Abstract] AND WASL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRKAG2(151292431)-WASL(123349277), # samples:3
Anticipated loss of major functional domain due to fusion event.	PRKAG2-WASL seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PRKAG2-WASL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PRKAG2-WASL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PRKAG2-WASL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKAG2	GO:0006469	negative regulation of protein kinase activity	17255938
Tgene	WASL	GO:0030041	actin filament polymerization	16767080
Tgene	WASL	GO:0045944	positive regulation of transcription by RNA polymerase II	16767080
Tgene	WASL	GO:1903526	negative regulation of membrane tubulation	18388313

Fusion gene breakpoints across PRKAG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WASL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-UT-A88C-01B	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
ChimerDB4	MESO	TCGA-UT-A88C	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-

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Fusion Gene ORF analysis for PRKAG2-WASL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000392801	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
In-frame	ENST00000287878	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
In-frame	ENST00000418337	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
In-frame	ENST00000433631	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
In-frame	ENST00000492843	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-
intron-3CDS	ENST00000461529	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000287878	PRKAG2	chr7	151292431	-	ENST00000223023	WASL	chr7	123349277	-	5354	1369	493	2769	758
ENST00000418337	PRKAG2	chr7	151292431	-	ENST00000223023	WASL	chr7	123349277	-	4380	395	77	1795	572
ENST00000433631	PRKAG2	chr7	151292431	-	ENST00000223023	WASL	chr7	123349277	-	4744	759	240	2159	639
ENST00000492843	PRKAG2	chr7	151292431	-	ENST00000223023	WASL	chr7	123349277	-	4798	813	291	2213	640

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000287878	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-	0.000218199	0.9997818
ENST00000418337	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-	0.00019714	0.9998029
ENST00000433631	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-	0.00103588	0.9989641
ENST00000492843	ENST00000223023	PRKAG2	chr7	151292431	-	WASL	chr7	123349277	-	0.000898486	0.9991015

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Fusion Genomic Features for PRKAG2-WASL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKAG2-WASL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151292431/chr7:123349277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

277_392

506.0

Compositional bias

Note=Pro-rich

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

485_505

506.0

Compositional bias

Note=Asp-rich

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

203_216

506.0

Domain

CRIB

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

405_422

506.0

Domain

WH2 1

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

433_450

506.0

Domain

WH2 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

275_335

288

570.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

357_415

288

570.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

430_492

288

570.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

504_562

288

570.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

275_335

244

526.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

357_415

244

526.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

430_492

244

526.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

504_562

244

526.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

275_335

329.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

357_415

329.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

430_492

329.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

504_562

329.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

370_391

288

570.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

370_391

244

526.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

370_391

329.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

319_322

288

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

383_384

288

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

458_459

288

570.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

474_477

288

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

530_531

288

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000287878

546_549

288

570.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

319_322

244

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

383_384

244

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

458_459

244

526.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

474_477

244

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

530_531

244

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000392801

546_549

244

526.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

319_322

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

383_384

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

458_459

329.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

474_477

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

530_531

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151292431

chr7:123349277

ENST00000418337

546_549

329.0

Nucleotide binding

AMP 3

Tgene

WASL

chr7:151292431

chr7:123349277

ENST00000223023

34_141

506.0

Domain

WH1

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Fusion Gene Sequence for PRKAG2-WASL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68649_68649_1_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000287878_WASL_chr7_123349277_ENST00000223023_length(transcript)=5354nt_BP=1369nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGACCTGAGCTC
CTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCC
CTCCAAAGGGTTCTTCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGACCAGCCCCGGCTCTCC
CAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCTCCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAA
AGAGTCTTCCCCCAACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAACCTCCGGCCTCTCCTCCTC
TCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTA
TGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACA
CTATGCTCCCTCCAAAGCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAGAAGCTGGAGTTCGAGGACGAAGC
AGTAGAAGACTCAGAAAGTGGTGTTTACATGCGATTCATGAGGTCACACAAGTGTTATGACATCGTTCCAACCAGTTCAAAGCTTGTTGT
CTTTGATACTACATTACAAACTATGTCTTCAGCAGTGGTGCAGTTATATGCAGCAGATCGGAACTGTATGTGGTCAAAGAAGTGCAGTGG
TGTTGCTTGTCTTGTTAAGGACAATCCACAGAGATCTTATTTTTTAAGAATATTTGACATTAAGGATGGGAAACTATTGTGGGAACAAGA
GCTATACAATAACTTTGTATATAATAGTCCTAGAGGATATTTTCATACCTTTGCTGGAGATACTTGTCAAGTTGCTCTTAATTTTGCCAA
TGAAGAAGAAGCAAAAAAATTTCGAAAAGCAGTTACAGACCTTTTGGGCCGTCGACAAAGGAAATCTGAGAAAAGACGAGATCCCCCAAA
TGGTCCTAATCTACCCATGGCTACAGTTGATATAAAAAATCCAGAAATCACAACAAATAGATTTTATGGTCCACAAGTCAACAACATCTC
CCATACCAAAGAAAAGAAGAAGGGAAAAGCTAAAAAGAAGAGATTAACCAAGGCAGATATAGGAACACCAAGCAATTTCCAGCACATTGG
ACATGTTGGTTGGGATCCAAATACAGGCTTTGATCTGAATAATTTGGATCCAGAATTGAAGAATCTTTTCGATATGTGTGGAATCTCAGA
GGCACAACTTAAAGACAGAGAAACATCAAAAGTTATATATGACTTTATTGAAAAAACAGGAGGTGTTGAAGCTGTTAAAAATGAACTGCG
GAGGCAAGCACCACCACCTCCACCACCATCAAGGGGAGGGCCACCTCCTCCTCCTCCCCCTCCACACAACTCAGGTCCTCCTCCTCCTCC
TGCTAGGGGAAGAGGCGCTCCTCCCCCACCACCTTCAAGAGCTCCCACAGCTGCACCTCCACCACCGCCTCCTTCCAGGCCAAGTGTAGC
AGTCCCTCCACCACCGCCAAATAGGATGTACCCTCCTCCACCTCCAGCCCTTCCCTCCTCAGCACCTTCAGGGCCTCCACCACCACCTCC
ATCTGTGTTGGGGGTAGGGCCAGTGGCACCACCCCCACCGCCTCCACCTCCACCTCCTCCTGGGCCACCGCCCCCGCCTGGCCTGCCTTC
TGATGGGGACCATCAGGTTCCAACTACTGCAGGAAACAAAGCAGCTCTTTTAGATCAAATTAGAGAGGGTGCTCAGCTAAAAAAAGTGGA
GCAGAACAGTCGGCCAGTGTCCTGCTCTGGACGAGATGCACTGTTAGACCAGATACGACAGGGTATCCAACTAAAATCTGTGGCTGATGG
CCAAGAGTCTACACCACCAACACCTGCACCCACTTCAGGAATTGTGGGTGCATTAATGGAAGTGATGCAGAAAAGGAGCAAAGCCATTCA
TTCTTCAGATGAAGATGAAGATGAAGATGATGAAGAAGATTTTGAGGATGATGATGAGTGGGAAGACTGATCTATATATTATATATATAT
ATATATTTTTAAGGTGAAATACTAAACACTACTTTCTGTCTGTGGATTCTGTAAAATTATCATGTAAATGTTCTACCAATTTGCTGTATA
TTTTTGTTGCCTTTTTTGCTTTTTTTTAATCTGTGCAATACCTCATTTAATCTGTAAAGGTTTGTCGTAATCCTCTACAAAGCTACTCCC
TGTTATTGTGTGCAAGTTTACACCAGGATGCTCACTTGATTTGTGAATATTTTTCATTCCATCAACAAGGGAGTTTAAATACTATATGTG
AGACTGACAAAAACCTTAATGTAATTTACTTATAATGCCAGAAGGAAAACACTATTTTCATACCCTACTTTTTCTGTACCTAAATTTTCT
TAAAAAAAAATCTAGTATAGCACTACATTCTTTTTTAAGTGATGCAGACCTTAGTTTCTTTAGCCCCTTTATTTTGAATACAATGCTACA
TATGAATGTTGAAGCTGATACATTGCACAGTTCTGTAGACATCACTACACCGATGTAGTTTCTCAAATTTTAGCAATATGCTCTACATAA
AATCACTACAGAGATACTAGTGGGGAAGACGATTAACACACCTCTTACAGTAATACTGCCTGTTATTGGTATAGCAGTGGTATTTGCAGA
CTGGGATCATAAGGAGCCCTTAAATACTTGTTATTGACTGGGGTTATTTTTATGCTGTAGCAAATGTGACAGGCTCTTTTTAGCAAAATT
TTTGAAAATTTTTTTGGTATTACTCTGAAACAAAATTTAAGTTGGAGTTTCAGGGATTTAGGGAGTAGTTTTCATTCTACATGAACTGAG
GTAATATTATGGTAACTCCAATATTTGGTTAAAAAAACTATACAAATCAGAATAGTACTAAAATACTGTAGAATTTTAGCATTTTTATTT
TGCACTTTGTGTGGATTGAGGTGTTCAGAAATACCAACCATAAAAATGTAATCTAGTTGGCAAAGGTGTGCGCTAAAACACGGAACCGAA
CATGCATTGATTTGGATAACTTTTGAGGGTTTTTGTCAAATAGCATGTGAAGAGTTACATTTTTCTTAAAAGATTGGTGGTCCCAATGTC
AGAGTTCTTGGAACAGATAACTGAATGATAGATTTTTTTTTTTTAAAGATAAAACTTTACAACCTGCACATTTGTTATGCATACTAAATG
GTGTGTTAAAATTAGGGTTTCTTTGCCTCTCTACACTACACTAATCTGCCTAAAGGTGGTTGTTTCATATTTATAATGCTAATTATCATA
CCTACCTACTTTAAATTTTAGGTAGAAAATTATCTGATTTAAATACAAACATATTTTTCTCACATTGAGTAATATGCATAATGTAGTTCC
AAATGTATTTCATTACTATAGTCACAATATCCAACTAAAAATTACGCTATCTAGAATTGTACCAACCAAAATCTCGTATTGGCAGATCTT
GACAGGCTGGACCTGCAAGATGTGGCTTGAATTTTAACCATTTATTACATAATCTCTAGTGATCATGCATCTAGTTATCATAAGAAATAA
TTTAAAAGGTTTTGTTGCTGAAAGCAGTAAGTGGTGCAGTAAAATACTTAAGTTATTCAAAGAATGTTATCTTTCTTGCAAGAGTAATTT
AAGCACATGGGAAAGATTCTAGACTTTTTGTTTCTTGCAACAACAGTGCCCTCTGCTGCTAGAAACCTTTTTCTACTTACTATCATTTTT
ATTGTGGCTTGAGCTCAGTCAATCTGGTGCAGATGAGGCTGGACAACTACTAACCAATAAAATCAGGAGTTTGTACAAAAGTTAAATGGA
ACATTATAATTATTTTAAGTAATGTTAATTGAAAAAATTTTTTCTTTTTGACAATATAAAAAACATTTTAAATTTCCTAGAAATGTCTTC
AGGGTAATGCCAATTTAAGATCTCTCTTAACTTGTGGCCAAGAAATTCTAGATTTTCCAGCTGACTTTGGTATAATATATATTTATCAGG
AACTTCTCTCAGCAGAGAGTACCCATTCTTCGAGTTCAAAGCACAATTTTAAACATGTAAAATGGATATATAATTTGCCAAAGGTAATTA
ATTTATTCTTTTTTTCTTAAAGAAGAAAAAGACATTGGTTGTTGTTACAAAAAGTCTAAATTACTGTTGGTTGAAACACAGCAGCTGTGG
AGTTCAGTCCAGGCATGAAGACTAAATCTGCTTTACCAAGTAAGGTGTAAGGTTGCATGTTTCAGTCCTCTACCATCCTGCACTGTGAGC
AGCACTATACCTGTGCGTTGTCTGAAAGCCTTCCGTATATTCTCCAGCTAAATGGTCGTCTGGTAGCCTTTGCATTTAACAAACTAGCAT
GAGGCTTTTTATATCTAAATGCTACGTGATAGACAATTTCAGCTAGCCACATATTGTATGTATGAGATTCATAAAGACTTTCAATCATTT
CATTTTCAGACAACTGAAATTTTGTTTAGTATGTGAATTCTTTTTTTGAAATGTATAGTGAATAGGATGTTGCACTGGTGGCAATTCATC

>68649_68649_1_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000287878_WASL_chr7_123349277_ENST00000223023_length(amino acids)=758AA_BP=290
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP
LESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMR
SHKCYDIVPTSSKLVVFDTTLQTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYF
HTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKR
LTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGP
PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPP
PPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGI

--------------------------------------------------------------
>68649_68649_2_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000418337_WASL_chr7_123349277_ENST00000223023_length(transcript)=4380nt_BP=395nt
GCGGCCGCGCCACCTGCGGCGGCGGCGGCGGCCTCGGGCGGGTGGGGGCAGCGCTCCCGCTCCGCCCCCGGCCCCCGCTGCCCGCGTCCC
CTGCCAGGCCCCTCCTCCCGGCGGCGCGGCAGAGCCAGGCCCCAGCGCTCGGCCGGCCGCGAGCCCGCCGGCCGGGGACGAGCGTCGCAG
CTCATGCTGATCGCTGTCCTCCTCCTCCCCCTCAGGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAGAAGCTGG
AGTTCGAGGACGAAGCAGTAGAAGACTCAGAAAGTGGTGTTTACATGCGATTCATGAGGTCACACAAGTGTTATGACATCGTTCCAACCA
GTTCAAAGCTTGTTGTCTTTGATACTACATTACAAACTATGTCTTCAGCAGTGGTGCAGTTATATGCAGCAGATCGGAACTGTATGTGGT
CAAAGAAGTGCAGTGGTGTTGCTTGTCTTGTTAAGGACAATCCACAGAGATCTTATTTTTTAAGAATATTTGACATTAAGGATGGGAAAC
TATTGTGGGAACAAGAGCTATACAATAACTTTGTATATAATAGTCCTAGAGGATATTTTCATACCTTTGCTGGAGATACTTGTCAAGTTG
CTCTTAATTTTGCCAATGAAGAAGAAGCAAAAAAATTTCGAAAAGCAGTTACAGACCTTTTGGGCCGTCGACAAAGGAAATCTGAGAAAA
GACGAGATCCCCCAAATGGTCCTAATCTACCCATGGCTACAGTTGATATAAAAAATCCAGAAATCACAACAAATAGATTTTATGGTCCAC
AAGTCAACAACATCTCCCATACCAAAGAAAAGAAGAAGGGAAAAGCTAAAAAGAAGAGATTAACCAAGGCAGATATAGGAACACCAAGCA
ATTTCCAGCACATTGGACATGTTGGTTGGGATCCAAATACAGGCTTTGATCTGAATAATTTGGATCCAGAATTGAAGAATCTTTTCGATA
TGTGTGGAATCTCAGAGGCACAACTTAAAGACAGAGAAACATCAAAAGTTATATATGACTTTATTGAAAAAACAGGAGGTGTTGAAGCTG
TTAAAAATGAACTGCGGAGGCAAGCACCACCACCTCCACCACCATCAAGGGGAGGGCCACCTCCTCCTCCTCCCCCTCCACACAACTCAG
GTCCTCCTCCTCCTCCTGCTAGGGGAAGAGGCGCTCCTCCCCCACCACCTTCAAGAGCTCCCACAGCTGCACCTCCACCACCGCCTCCTT
CCAGGCCAAGTGTAGCAGTCCCTCCACCACCGCCAAATAGGATGTACCCTCCTCCACCTCCAGCCCTTCCCTCCTCAGCACCTTCAGGGC
CTCCACCACCACCTCCATCTGTGTTGGGGGTAGGGCCAGTGGCACCACCCCCACCGCCTCCACCTCCACCTCCTCCTGGGCCACCGCCCC
CGCCTGGCCTGCCTTCTGATGGGGACCATCAGGTTCCAACTACTGCAGGAAACAAAGCAGCTCTTTTAGATCAAATTAGAGAGGGTGCTC
AGCTAAAAAAAGTGGAGCAGAACAGTCGGCCAGTGTCCTGCTCTGGACGAGATGCACTGTTAGACCAGATACGACAGGGTATCCAACTAA
AATCTGTGGCTGATGGCCAAGAGTCTACACCACCAACACCTGCACCCACTTCAGGAATTGTGGGTGCATTAATGGAAGTGATGCAGAAAA
GGAGCAAAGCCATTCATTCTTCAGATGAAGATGAAGATGAAGATGATGAAGAAGATTTTGAGGATGATGATGAGTGGGAAGACTGATCTA
TATATTATATATATATATATATTTTTAAGGTGAAATACTAAACACTACTTTCTGTCTGTGGATTCTGTAAAATTATCATGTAAATGTTCT
ACCAATTTGCTGTATATTTTTGTTGCCTTTTTTGCTTTTTTTTAATCTGTGCAATACCTCATTTAATCTGTAAAGGTTTGTCGTAATCCT
CTACAAAGCTACTCCCTGTTATTGTGTGCAAGTTTACACCAGGATGCTCACTTGATTTGTGAATATTTTTCATTCCATCAACAAGGGAGT
TTAAATACTATATGTGAGACTGACAAAAACCTTAATGTAATTTACTTATAATGCCAGAAGGAAAACACTATTTTCATACCCTACTTTTTC
TGTACCTAAATTTTCTTAAAAAAAAATCTAGTATAGCACTACATTCTTTTTTAAGTGATGCAGACCTTAGTTTCTTTAGCCCCTTTATTT
TGAATACAATGCTACATATGAATGTTGAAGCTGATACATTGCACAGTTCTGTAGACATCACTACACCGATGTAGTTTCTCAAATTTTAGC
AATATGCTCTACATAAAATCACTACAGAGATACTAGTGGGGAAGACGATTAACACACCTCTTACAGTAATACTGCCTGTTATTGGTATAG
CAGTGGTATTTGCAGACTGGGATCATAAGGAGCCCTTAAATACTTGTTATTGACTGGGGTTATTTTTATGCTGTAGCAAATGTGACAGGC
TCTTTTTAGCAAAATTTTTGAAAATTTTTTTGGTATTACTCTGAAACAAAATTTAAGTTGGAGTTTCAGGGATTTAGGGAGTAGTTTTCA
TTCTACATGAACTGAGGTAATATTATGGTAACTCCAATATTTGGTTAAAAAAACTATACAAATCAGAATAGTACTAAAATACTGTAGAAT
TTTAGCATTTTTATTTTGCACTTTGTGTGGATTGAGGTGTTCAGAAATACCAACCATAAAAATGTAATCTAGTTGGCAAAGGTGTGCGCT
AAAACACGGAACCGAACATGCATTGATTTGGATAACTTTTGAGGGTTTTTGTCAAATAGCATGTGAAGAGTTACATTTTTCTTAAAAGAT
TGGTGGTCCCAATGTCAGAGTTCTTGGAACAGATAACTGAATGATAGATTTTTTTTTTTTAAAGATAAAACTTTACAACCTGCACATTTG
TTATGCATACTAAATGGTGTGTTAAAATTAGGGTTTCTTTGCCTCTCTACACTACACTAATCTGCCTAAAGGTGGTTGTTTCATATTTAT
AATGCTAATTATCATACCTACCTACTTTAAATTTTAGGTAGAAAATTATCTGATTTAAATACAAACATATTTTTCTCACATTGAGTAATA
TGCATAATGTAGTTCCAAATGTATTTCATTACTATAGTCACAATATCCAACTAAAAATTACGCTATCTAGAATTGTACCAACCAAAATCT
CGTATTGGCAGATCTTGACAGGCTGGACCTGCAAGATGTGGCTTGAATTTTAACCATTTATTACATAATCTCTAGTGATCATGCATCTAG
TTATCATAAGAAATAATTTAAAAGGTTTTGTTGCTGAAAGCAGTAAGTGGTGCAGTAAAATACTTAAGTTATTCAAAGAATGTTATCTTT
CTTGCAAGAGTAATTTAAGCACATGGGAAAGATTCTAGACTTTTTGTTTCTTGCAACAACAGTGCCCTCTGCTGCTAGAAACCTTTTTCT
ACTTACTATCATTTTTATTGTGGCTTGAGCTCAGTCAATCTGGTGCAGATGAGGCTGGACAACTACTAACCAATAAAATCAGGAGTTTGT
ACAAAAGTTAAATGGAACATTATAATTATTTTAAGTAATGTTAATTGAAAAAATTTTTTCTTTTTGACAATATAAAAAACATTTTAAATT
TCCTAGAAATGTCTTCAGGGTAATGCCAATTTAAGATCTCTCTTAACTTGTGGCCAAGAAATTCTAGATTTTCCAGCTGACTTTGGTATA
ATATATATTTATCAGGAACTTCTCTCAGCAGAGAGTACCCATTCTTCGAGTTCAAAGCACAATTTTAAACATGTAAAATGGATATATAAT
TTGCCAAAGGTAATTAATTTATTCTTTTTTTCTTAAAGAAGAAAAAGACATTGGTTGTTGTTACAAAAAGTCTAAATTACTGTTGGTTGA
AACACAGCAGCTGTGGAGTTCAGTCCAGGCATGAAGACTAAATCTGCTTTACCAAGTAAGGTGTAAGGTTGCATGTTTCAGTCCTCTACC
ATCCTGCACTGTGAGCAGCACTATACCTGTGCGTTGTCTGAAAGCCTTCCGTATATTCTCCAGCTAAATGGTCGTCTGGTAGCCTTTGCA
TTTAACAAACTAGCATGAGGCTTTTTATATCTAAATGCTACGTGATAGACAATTTCAGCTAGCCACATATTGTATGTATGAGATTCATAA
AGACTTTCAATCATTTCATTTTCAGACAACTGAAATTTTGTTTAGTATGTGAATTCTTTTTTTGAAATGTATAGTGAATAGGATGTTGCA

>68649_68649_2_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000418337_WASL_chr7_123349277_ENST00000223023_length(amino acids)=572AA_BP=104
MPASPARPLLPAARQSQAPALGRPRARRPGTSVAAHADRCPPPPPQAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYD
IVPTSSKLVVFDTTLQTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGD
TCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADI
GTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPP
PHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPP
GPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALME

--------------------------------------------------------------
>68649_68649_3_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000433631_WASL_chr7_123349277_ENST00000223023_length(transcript)=4744nt_BP=759nt
GCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCACTCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACC
CCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGCACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATG
CTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTCTGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCC
ATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACACAAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTT
TTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCT
GAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGG
CCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAAGCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAG
AAGCTGGAGTTCGAGGACGAAGTAGAAGACTCAGAAAGTGGTGTTTACATGCGATTCATGAGGTCACACAAGTGTTATGACATCGTTCCA
ACCAGTTCAAAGCTTGTTGTCTTTGATACTACATTACAAACTATGTCTTCAGCAGTGGTGCAGTTATATGCAGCAGATCGGAACTGTATG
TGGTCAAAGAAGTGCAGTGGTGTTGCTTGTCTTGTTAAGGACAATCCACAGAGATCTTATTTTTTAAGAATATTTGACATTAAGGATGGG
AAACTATTGTGGGAACAAGAGCTATACAATAACTTTGTATATAATAGTCCTAGAGGATATTTTCATACCTTTGCTGGAGATACTTGTCAA
GTTGCTCTTAATTTTGCCAATGAAGAAGAAGCAAAAAAATTTCGAAAAGCAGTTACAGACCTTTTGGGCCGTCGACAAAGGAAATCTGAG
AAAAGACGAGATCCCCCAAATGGTCCTAATCTACCCATGGCTACAGTTGATATAAAAAATCCAGAAATCACAACAAATAGATTTTATGGT
CCACAAGTCAACAACATCTCCCATACCAAAGAAAAGAAGAAGGGAAAAGCTAAAAAGAAGAGATTAACCAAGGCAGATATAGGAACACCA
AGCAATTTCCAGCACATTGGACATGTTGGTTGGGATCCAAATACAGGCTTTGATCTGAATAATTTGGATCCAGAATTGAAGAATCTTTTC
GATATGTGTGGAATCTCAGAGGCACAACTTAAAGACAGAGAAACATCAAAAGTTATATATGACTTTATTGAAAAAACAGGAGGTGTTGAA
GCTGTTAAAAATGAACTGCGGAGGCAAGCACCACCACCTCCACCACCATCAAGGGGAGGGCCACCTCCTCCTCCTCCCCCTCCACACAAC
TCAGGTCCTCCTCCTCCTCCTGCTAGGGGAAGAGGCGCTCCTCCCCCACCACCTTCAAGAGCTCCCACAGCTGCACCTCCACCACCGCCT
CCTTCCAGGCCAAGTGTAGCAGTCCCTCCACCACCGCCAAATAGGATGTACCCTCCTCCACCTCCAGCCCTTCCCTCCTCAGCACCTTCA
GGGCCTCCACCACCACCTCCATCTGTGTTGGGGGTAGGGCCAGTGGCACCACCCCCACCGCCTCCACCTCCACCTCCTCCTGGGCCACCG
CCCCCGCCTGGCCTGCCTTCTGATGGGGACCATCAGGTTCCAACTACTGCAGGAAACAAAGCAGCTCTTTTAGATCAAATTAGAGAGGGT
GCTCAGCTAAAAAAAGTGGAGCAGAACAGTCGGCCAGTGTCCTGCTCTGGACGAGATGCACTGTTAGACCAGATACGACAGGGTATCCAA
CTAAAATCTGTGGCTGATGGCCAAGAGTCTACACCACCAACACCTGCACCCACTTCAGGAATTGTGGGTGCATTAATGGAAGTGATGCAG
AAAAGGAGCAAAGCCATTCATTCTTCAGATGAAGATGAAGATGAAGATGATGAAGAAGATTTTGAGGATGATGATGAGTGGGAAGACTGA
TCTATATATTATATATATATATATATTTTTAAGGTGAAATACTAAACACTACTTTCTGTCTGTGGATTCTGTAAAATTATCATGTAAATG
TTCTACCAATTTGCTGTATATTTTTGTTGCCTTTTTTGCTTTTTTTTAATCTGTGCAATACCTCATTTAATCTGTAAAGGTTTGTCGTAA
TCCTCTACAAAGCTACTCCCTGTTATTGTGTGCAAGTTTACACCAGGATGCTCACTTGATTTGTGAATATTTTTCATTCCATCAACAAGG
GAGTTTAAATACTATATGTGAGACTGACAAAAACCTTAATGTAATTTACTTATAATGCCAGAAGGAAAACACTATTTTCATACCCTACTT
TTTCTGTACCTAAATTTTCTTAAAAAAAAATCTAGTATAGCACTACATTCTTTTTTAAGTGATGCAGACCTTAGTTTCTTTAGCCCCTTT
ATTTTGAATACAATGCTACATATGAATGTTGAAGCTGATACATTGCACAGTTCTGTAGACATCACTACACCGATGTAGTTTCTCAAATTT
TAGCAATATGCTCTACATAAAATCACTACAGAGATACTAGTGGGGAAGACGATTAACACACCTCTTACAGTAATACTGCCTGTTATTGGT
ATAGCAGTGGTATTTGCAGACTGGGATCATAAGGAGCCCTTAAATACTTGTTATTGACTGGGGTTATTTTTATGCTGTAGCAAATGTGAC
AGGCTCTTTTTAGCAAAATTTTTGAAAATTTTTTTGGTATTACTCTGAAACAAAATTTAAGTTGGAGTTTCAGGGATTTAGGGAGTAGTT
TTCATTCTACATGAACTGAGGTAATATTATGGTAACTCCAATATTTGGTTAAAAAAACTATACAAATCAGAATAGTACTAAAATACTGTA
GAATTTTAGCATTTTTATTTTGCACTTTGTGTGGATTGAGGTGTTCAGAAATACCAACCATAAAAATGTAATCTAGTTGGCAAAGGTGTG
CGCTAAAACACGGAACCGAACATGCATTGATTTGGATAACTTTTGAGGGTTTTTGTCAAATAGCATGTGAAGAGTTACATTTTTCTTAAA
AGATTGGTGGTCCCAATGTCAGAGTTCTTGGAACAGATAACTGAATGATAGATTTTTTTTTTTTAAAGATAAAACTTTACAACCTGCACA
TTTGTTATGCATACTAAATGGTGTGTTAAAATTAGGGTTTCTTTGCCTCTCTACACTACACTAATCTGCCTAAAGGTGGTTGTTTCATAT
TTATAATGCTAATTATCATACCTACCTACTTTAAATTTTAGGTAGAAAATTATCTGATTTAAATACAAACATATTTTTCTCACATTGAGT
AATATGCATAATGTAGTTCCAAATGTATTTCATTACTATAGTCACAATATCCAACTAAAAATTACGCTATCTAGAATTGTACCAACCAAA
ATCTCGTATTGGCAGATCTTGACAGGCTGGACCTGCAAGATGTGGCTTGAATTTTAACCATTTATTACATAATCTCTAGTGATCATGCAT
CTAGTTATCATAAGAAATAATTTAAAAGGTTTTGTTGCTGAAAGCAGTAAGTGGTGCAGTAAAATACTTAAGTTATTCAAAGAATGTTAT
CTTTCTTGCAAGAGTAATTTAAGCACATGGGAAAGATTCTAGACTTTTTGTTTCTTGCAACAACAGTGCCCTCTGCTGCTAGAAACCTTT
TTCTACTTACTATCATTTTTATTGTGGCTTGAGCTCAGTCAATCTGGTGCAGATGAGGCTGGACAACTACTAACCAATAAAATCAGGAGT
TTGTACAAAAGTTAAATGGAACATTATAATTATTTTAAGTAATGTTAATTGAAAAAATTTTTTCTTTTTGACAATATAAAAAACATTTTA
AATTTCCTAGAAATGTCTTCAGGGTAATGCCAATTTAAGATCTCTCTTAACTTGTGGCCAAGAAATTCTAGATTTTCCAGCTGACTTTGG
TATAATATATATTTATCAGGAACTTCTCTCAGCAGAGAGTACCCATTCTTCGAGTTCAAAGCACAATTTTAAACATGTAAAATGGATATA
TAATTTGCCAAAGGTAATTAATTTATTCTTTTTTTCTTAAAGAAGAAAAAGACATTGGTTGTTGTTACAAAAAGTCTAAATTACTGTTGG
TTGAAACACAGCAGCTGTGGAGTTCAGTCCAGGCATGAAGACTAAATCTGCTTTACCAAGTAAGGTGTAAGGTTGCATGTTTCAGTCCTC
TACCATCCTGCACTGTGAGCAGCACTATACCTGTGCGTTGTCTGAAAGCCTTCCGTATATTCTCCAGCTAAATGGTCGTCTGGTAGCCTT
TGCATTTAACAAACTAGCATGAGGCTTTTTATATCTAAATGCTACGTGATAGACAATTTCAGCTAGCCACATATTGTATGTATGAGATTC
ATAAAGACTTTCAATCATTTCATTTTCAGACAACTGAAATTTTGTTTAGTATGTGAATTCTTTTTTTGAAATGTATAGTGAATAGGATGT

>68649_68649_3_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000433631_WASL_chr7_123349277_ENST00000223023_length(amino acids)=639AA_BP=171
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQTMSSAVV
QLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTD
LLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLN
NLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSR
APTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNK
AALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEED

--------------------------------------------------------------
>68649_68649_4_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000492843_WASL_chr7_123349277_ENST00000223023_length(transcript)=4798nt_BP=813nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACC
CAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCC
CCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAA
GCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAGAAGCTGGAGTTCGAGGACGAAGCAGTAGAAGACTCAGAA
AGTGGTGTTTACATGCGATTCATGAGGTCACACAAGTGTTATGACATCGTTCCAACCAGTTCAAAGCTTGTTGTCTTTGATACTACATTA
CAAACTATGTCTTCAGCAGTGGTGCAGTTATATGCAGCAGATCGGAACTGTATGTGGTCAAAGAAGTGCAGTGGTGTTGCTTGTCTTGTT
AAGGACAATCCACAGAGATCTTATTTTTTAAGAATATTTGACATTAAGGATGGGAAACTATTGTGGGAACAAGAGCTATACAATAACTTT
GTATATAATAGTCCTAGAGGATATTTTCATACCTTTGCTGGAGATACTTGTCAAGTTGCTCTTAATTTTGCCAATGAAGAAGAAGCAAAA
AAATTTCGAAAAGCAGTTACAGACCTTTTGGGCCGTCGACAAAGGAAATCTGAGAAAAGACGAGATCCCCCAAATGGTCCTAATCTACCC
ATGGCTACAGTTGATATAAAAAATCCAGAAATCACAACAAATAGATTTTATGGTCCACAAGTCAACAACATCTCCCATACCAAAGAAAAG
AAGAAGGGAAAAGCTAAAAAGAAGAGATTAACCAAGGCAGATATAGGAACACCAAGCAATTTCCAGCACATTGGACATGTTGGTTGGGAT
CCAAATACAGGCTTTGATCTGAATAATTTGGATCCAGAATTGAAGAATCTTTTCGATATGTGTGGAATCTCAGAGGCACAACTTAAAGAC
AGAGAAACATCAAAAGTTATATATGACTTTATTGAAAAAACAGGAGGTGTTGAAGCTGTTAAAAATGAACTGCGGAGGCAAGCACCACCA
CCTCCACCACCATCAAGGGGAGGGCCACCTCCTCCTCCTCCCCCTCCACACAACTCAGGTCCTCCTCCTCCTCCTGCTAGGGGAAGAGGC
GCTCCTCCCCCACCACCTTCAAGAGCTCCCACAGCTGCACCTCCACCACCGCCTCCTTCCAGGCCAAGTGTAGCAGTCCCTCCACCACCG
CCAAATAGGATGTACCCTCCTCCACCTCCAGCCCTTCCCTCCTCAGCACCTTCAGGGCCTCCACCACCACCTCCATCTGTGTTGGGGGTA
GGGCCAGTGGCACCACCCCCACCGCCTCCACCTCCACCTCCTCCTGGGCCACCGCCCCCGCCTGGCCTGCCTTCTGATGGGGACCATCAG
GTTCCAACTACTGCAGGAAACAAAGCAGCTCTTTTAGATCAAATTAGAGAGGGTGCTCAGCTAAAAAAAGTGGAGCAGAACAGTCGGCCA
GTGTCCTGCTCTGGACGAGATGCACTGTTAGACCAGATACGACAGGGTATCCAACTAAAATCTGTGGCTGATGGCCAAGAGTCTACACCA
CCAACACCTGCACCCACTTCAGGAATTGTGGGTGCATTAATGGAAGTGATGCAGAAAAGGAGCAAAGCCATTCATTCTTCAGATGAAGAT
GAAGATGAAGATGATGAAGAAGATTTTGAGGATGATGATGAGTGGGAAGACTGATCTATATATTATATATATATATATATTTTTAAGGTG
AAATACTAAACACTACTTTCTGTCTGTGGATTCTGTAAAATTATCATGTAAATGTTCTACCAATTTGCTGTATATTTTTGTTGCCTTTTT
TGCTTTTTTTTAATCTGTGCAATACCTCATTTAATCTGTAAAGGTTTGTCGTAATCCTCTACAAAGCTACTCCCTGTTATTGTGTGCAAG
TTTACACCAGGATGCTCACTTGATTTGTGAATATTTTTCATTCCATCAACAAGGGAGTTTAAATACTATATGTGAGACTGACAAAAACCT
TAATGTAATTTACTTATAATGCCAGAAGGAAAACACTATTTTCATACCCTACTTTTTCTGTACCTAAATTTTCTTAAAAAAAAATCTAGT
ATAGCACTACATTCTTTTTTAAGTGATGCAGACCTTAGTTTCTTTAGCCCCTTTATTTTGAATACAATGCTACATATGAATGTTGAAGCT
GATACATTGCACAGTTCTGTAGACATCACTACACCGATGTAGTTTCTCAAATTTTAGCAATATGCTCTACATAAAATCACTACAGAGATA
CTAGTGGGGAAGACGATTAACACACCTCTTACAGTAATACTGCCTGTTATTGGTATAGCAGTGGTATTTGCAGACTGGGATCATAAGGAG
CCCTTAAATACTTGTTATTGACTGGGGTTATTTTTATGCTGTAGCAAATGTGACAGGCTCTTTTTAGCAAAATTTTTGAAAATTTTTTTG
GTATTACTCTGAAACAAAATTTAAGTTGGAGTTTCAGGGATTTAGGGAGTAGTTTTCATTCTACATGAACTGAGGTAATATTATGGTAAC
TCCAATATTTGGTTAAAAAAACTATACAAATCAGAATAGTACTAAAATACTGTAGAATTTTAGCATTTTTATTTTGCACTTTGTGTGGAT
TGAGGTGTTCAGAAATACCAACCATAAAAATGTAATCTAGTTGGCAAAGGTGTGCGCTAAAACACGGAACCGAACATGCATTGATTTGGA
TAACTTTTGAGGGTTTTTGTCAAATAGCATGTGAAGAGTTACATTTTTCTTAAAAGATTGGTGGTCCCAATGTCAGAGTTCTTGGAACAG
ATAACTGAATGATAGATTTTTTTTTTTTAAAGATAAAACTTTACAACCTGCACATTTGTTATGCATACTAAATGGTGTGTTAAAATTAGG
GTTTCTTTGCCTCTCTACACTACACTAATCTGCCTAAAGGTGGTTGTTTCATATTTATAATGCTAATTATCATACCTACCTACTTTAAAT
TTTAGGTAGAAAATTATCTGATTTAAATACAAACATATTTTTCTCACATTGAGTAATATGCATAATGTAGTTCCAAATGTATTTCATTAC
TATAGTCACAATATCCAACTAAAAATTACGCTATCTAGAATTGTACCAACCAAAATCTCGTATTGGCAGATCTTGACAGGCTGGACCTGC
AAGATGTGGCTTGAATTTTAACCATTTATTACATAATCTCTAGTGATCATGCATCTAGTTATCATAAGAAATAATTTAAAAGGTTTTGTT
GCTGAAAGCAGTAAGTGGTGCAGTAAAATACTTAAGTTATTCAAAGAATGTTATCTTTCTTGCAAGAGTAATTTAAGCACATGGGAAAGA
TTCTAGACTTTTTGTTTCTTGCAACAACAGTGCCCTCTGCTGCTAGAAACCTTTTTCTACTTACTATCATTTTTATTGTGGCTTGAGCTC
AGTCAATCTGGTGCAGATGAGGCTGGACAACTACTAACCAATAAAATCAGGAGTTTGTACAAAAGTTAAATGGAACATTATAATTATTTT
AAGTAATGTTAATTGAAAAAATTTTTTCTTTTTGACAATATAAAAAACATTTTAAATTTCCTAGAAATGTCTTCAGGGTAATGCCAATTT
AAGATCTCTCTTAACTTGTGGCCAAGAAATTCTAGATTTTCCAGCTGACTTTGGTATAATATATATTTATCAGGAACTTCTCTCAGCAGA
GAGTACCCATTCTTCGAGTTCAAAGCACAATTTTAAACATGTAAAATGGATATATAATTTGCCAAAGGTAATTAATTTATTCTTTTTTTC
TTAAAGAAGAAAAAGACATTGGTTGTTGTTACAAAAAGTCTAAATTACTGTTGGTTGAAACACAGCAGCTGTGGAGTTCAGTCCAGGCAT
GAAGACTAAATCTGCTTTACCAAGTAAGGTGTAAGGTTGCATGTTTCAGTCCTCTACCATCCTGCACTGTGAGCAGCACTATACCTGTGC
GTTGTCTGAAAGCCTTCCGTATATTCTCCAGCTAAATGGTCGTCTGGTAGCCTTTGCATTTAACAAACTAGCATGAGGCTTTTTATATCT
AAATGCTACGTGATAGACAATTTCAGCTAGCCACATATTGTATGTATGAGATTCATAAAGACTTTCAATCATTTCATTTTCAGACAACTG
AAATTTTGTTTAGTATGTGAATTCTTTTTTTGAAATGTATAGTGAATAGGATGTTGCACTGGTGGCAATTCATCATGGAGCATAATAAAA

>68649_68649_4_PRKAG2-WASL_PRKAG2_chr7_151292431_ENST00000492843_WASL_chr7_123349277_ENST00000223023_length(amino acids)=640AA_BP=172
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQTMSSAV
VQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVT
DLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDL
NNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPS
RAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGN
KAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEE

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Fusion Gene PPI Analysis for PRKAG2-WASL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PRKAG2-WASL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PRKAG2-WASL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source