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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRKAR1B-MAD1L1 (FusionGDB2 ID:68671)

Fusion Gene Summary for PRKAR1B-MAD1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAR1B-MAD1L1
Fusion gene ID: 68671
HgeneTgene
Gene symbol

PRKAR1B

MAD1L1

Gene ID

5575

8379

Gene nameprotein kinase cAMP-dependent type I regulatory subunit betamitotic arrest deficient 1 like 1
SynonymsPRKAR1MAD1|PIG9|TP53I9|TXBP181
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type I-beta regulatory subunitprotein kinase, cAMP-dependent, regulatory subunit type I betaprotein kinase, cAMP-dependent, regulatory, type I, betamitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote
Modification date2020032720200313
UniProtAcc.

Q9Y6D9

Ensembl transtripts involved in fusion geneENST00000360274, ENST00000403562, 
ENST00000406797, ENST00000537384, 
ENST00000544935, ENST00000488474, 
ENST00000486340, ENST00000265854, 
ENST00000399654, ENST00000402746, 
ENST00000406869, 
Fusion gene scores* DoF score6 X 6 X 5=18023 X 16 X 12=4416
# samples 737
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/4416*10)=-3.57714299626186
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAR1B [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAD1L1(2108828)-PRKAR1B(591107), # samples:1
PRKAR1B(645830)-MAD1L1(2020176), # samples:1
Anticipated loss of major functional domain due to fusion event.MAD1L1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MAD1L1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
MAD1L1-PRKAR1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAD1L1-PRKAR1B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKAR1B-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PRKAR1B-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKAR1B-MAD1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PRKAR1B-MAD1L1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR1B

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984

TgeneMAD1L1

GO:0007094

mitotic spindle assembly checkpoint

18981471

TgeneMAD1L1

GO:0090235

regulation of metaphase plate congression

20133940


check buttonFusion gene breakpoints across PRKAR1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAD1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01APRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-


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Fusion Gene ORF analysis for PRKAR1B-MAD1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360274ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
5CDS-intronENST00000403562ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
5CDS-intronENST00000406797ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
5CDS-intronENST00000537384ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
5CDS-intronENST00000544935ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000360274ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000360274ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000360274ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000360274ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000537384ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000537384ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000537384ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
Frame-shiftENST00000537384ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000403562ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000403562ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000403562ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000403562ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000406797ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000406797ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000406797ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000406797ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000544935ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000544935ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000544935ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
In-frameENST00000544935ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
intron-3CDSENST00000488474ENST00000265854PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
intron-3CDSENST00000488474ENST00000399654PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
intron-3CDSENST00000488474ENST00000402746PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
intron-3CDSENST00000488474ENST00000406869PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-
intron-intronENST00000488474ENST00000486340PRKAR1Bchr7

645830

-MAD1L1chr7

2020176

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544935PRKAR1Bchr7645830-ENST00000402746MAD1L1chr72020176-16816641151404429
ENST00000544935PRKAR1Bchr7645830-ENST00000399654MAD1L1chr72020176-16816641151404429
ENST00000544935PRKAR1Bchr7645830-ENST00000406869MAD1L1chr72020176-16816641151404429
ENST00000544935PRKAR1Bchr7645830-ENST00000265854MAD1L1chr72020176-16646641151404429
ENST00000406797PRKAR1Bchr7645830-ENST00000402746MAD1L1chr72020176-17417241361464442
ENST00000406797PRKAR1Bchr7645830-ENST00000399654MAD1L1chr72020176-17417241361464442
ENST00000406797PRKAR1Bchr7645830-ENST00000406869MAD1L1chr72020176-17417241361464442
ENST00000406797PRKAR1Bchr7645830-ENST00000265854MAD1L1chr72020176-17247241361464442
ENST00000403562PRKAR1Bchr7645830-ENST00000402746MAD1L1chr72020176-1649632831372429
ENST00000403562PRKAR1Bchr7645830-ENST00000399654MAD1L1chr72020176-1649632831372429
ENST00000403562PRKAR1Bchr7645830-ENST00000406869MAD1L1chr72020176-1649632831372429
ENST00000403562PRKAR1Bchr7645830-ENST00000265854MAD1L1chr72020176-1632632831372429

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544935ENST00000402746PRKAR1Bchr7645830-MAD1L1chr72020176-0.0130608370.9869392
ENST00000544935ENST00000399654PRKAR1Bchr7645830-MAD1L1chr72020176-0.0130608370.9869392
ENST00000544935ENST00000406869PRKAR1Bchr7645830-MAD1L1chr72020176-0.0130608370.9869392
ENST00000544935ENST00000265854PRKAR1Bchr7645830-MAD1L1chr72020176-0.0125701610.9874298
ENST00000406797ENST00000402746PRKAR1Bchr7645830-MAD1L1chr72020176-0.0110247170.9889753
ENST00000406797ENST00000399654PRKAR1Bchr7645830-MAD1L1chr72020176-0.0110247170.9889753
ENST00000406797ENST00000406869PRKAR1Bchr7645830-MAD1L1chr72020176-0.0110247170.9889753
ENST00000406797ENST00000265854PRKAR1Bchr7645830-MAD1L1chr72020176-0.0105274470.98947257
ENST00000403562ENST00000402746PRKAR1Bchr7645830-MAD1L1chr72020176-0.0119679520.988032
ENST00000403562ENST00000399654PRKAR1Bchr7645830-MAD1L1chr72020176-0.0119679520.988032
ENST00000403562ENST00000406869PRKAR1Bchr7645830-MAD1L1chr72020176-0.0119679520.988032
ENST00000403562ENST00000265854PRKAR1Bchr7645830-MAD1L1chr72020176-0.011394090.9886059

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Fusion Genomic Features for PRKAR1B-MAD1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKAR1B-MAD1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:2108828/chr7:591107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAD1L1

Q9Y6D9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000360274-61196_100183382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000403562-61196_100183382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000406797-61196_100183382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000537384-61196_100183382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000544935-61196_100183382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000360274-6112_136183382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000403562-6112_136183382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000406797-6112_136183382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000537384-6112_136183382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000544935-6112_136183382.0RegionNote=Dimerization and phosphorylation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000360274-611137_254183382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000360274-611255_381183382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000403562-611137_254183382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000403562-611255_381183382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000406797-611137_254183382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000406797-611255_381183382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000537384-611137_254183382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000537384-611255_381183382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000544935-611137_254183382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Bchr7:645830chr7:2020176ENST00000544935-611255_381183382.0Nucleotide bindingNote=cAMP 2
TgeneMAD1L1chr7:645830chr7:2020176ENST00000265854121846_632472719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:645830chr7:2020176ENST00000399654131946_632472719.0Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr7:645830chr7:2020176ENST00000406869131946_632472719.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for PRKAR1B-MAD1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68671_68671_1_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000265854_length(transcript)=1632nt_BP=632nt
GTGAGGGCCAAGCAGGAACAGGGGTCACGGGGCAAGGAGCACGTGGCAGCGCAGGAAACAGGAAGGAAGCAGCCACCCTCGCCATGGCCT
CCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAAAG
ACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAACA
GGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAAGG
CCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTACA
AAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGCCA
TGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGTGG
ATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCA
GGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGC
AGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACA
GCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCG
CCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTT
TCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGA
CCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGT
TCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCT
TCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCC
AGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCT
GCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCAC

>68671_68671_1_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000265854_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_2_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000399654_length(transcript)=1649nt_BP=632nt
GTGAGGGCCAAGCAGGAACAGGGGTCACGGGGCAAGGAGCACGTGGCAGCGCAGGAAACAGGAAGGAAGCAGCCACCCTCGCCATGGCCT
CCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAAAG
ACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAACA
GGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAAGG
CCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTACA
AAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGCCA
TGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGTGG
ATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCA
GGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGC
AGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACA
GCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCG
CCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTT
TCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGA
CCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGT
TCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCT
TCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCC
AGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCT
GCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCAC

>68671_68671_2_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000399654_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_3_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000402746_length(transcript)=1649nt_BP=632nt
GTGAGGGCCAAGCAGGAACAGGGGTCACGGGGCAAGGAGCACGTGGCAGCGCAGGAAACAGGAAGGAAGCAGCCACCCTCGCCATGGCCT
CCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAAAG
ACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAACA
GGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAAGG
CCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTACA
AAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGCCA
TGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGTGG
ATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCA
GGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGC
AGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACA
GCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCG
CCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTT
TCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGA
CCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGT
TCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCT
TCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCC
AGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCT
GCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCAC

>68671_68671_3_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000402746_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_4_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000406869_length(transcript)=1649nt_BP=632nt
GTGAGGGCCAAGCAGGAACAGGGGTCACGGGGCAAGGAGCACGTGGCAGCGCAGGAAACAGGAAGGAAGCAGCCACCCTCGCCATGGCCT
CCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAAAG
ACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAACA
GGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAAGG
CCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTACA
AAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGCCA
TGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGTGG
ATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCTCA
GGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGC
AGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCACA
GCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCG
CCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGTTT
TCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCTGA
CCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGAGT
TCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCT
TCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCGCC
AGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTCCT
GCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTCAC

>68671_68671_4_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000403562_MAD1L1_chr7_2020176_ENST00000406869_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_5_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000265854_length(transcript)=1724nt_BP=724nt
AGTTTCTGCCGCCGCCACCCTGGCAGGATGGGGCAACGGTGTGCGGTAGGAGGATGAGGTTGATTCCCTTTCCTGCAGGGCTGGGCTTGT
GGGTTAGGACCGTCACCAAGAGGCTCCTCCTAGGCCTCCGTGACCTCTGGATCCCCAAGAAAGGAAGGAAGCAGCCACCCTCGCCATGGC
CTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAA
AGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAA
CAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAA
GGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTA
CAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGC
CATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGT
GGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCT
CAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCT
GCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCA
CAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGC
CGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGT
TTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCT
GACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGA
GTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCT
CTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCG
CCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTC
CTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTC

>68671_68671_5_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000265854_length(amino acids)=442AA_BP=196
MDPQERKEAATLAMASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDS
HDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQ
GNEGDNFYVVDQGEVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS
LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL

--------------------------------------------------------------
>68671_68671_6_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000399654_length(transcript)=1741nt_BP=724nt
AGTTTCTGCCGCCGCCACCCTGGCAGGATGGGGCAACGGTGTGCGGTAGGAGGATGAGGTTGATTCCCTTTCCTGCAGGGCTGGGCTTGT
GGGTTAGGACCGTCACCAAGAGGCTCCTCCTAGGCCTCCGTGACCTCTGGATCCCCAAGAAAGGAAGGAAGCAGCCACCCTCGCCATGGC
CTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAA
AGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAA
CAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAA
GGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTA
CAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGC
CATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGT
GGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCT
CAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCT
GCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCA
CAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGC
CGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGT
TTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCT
GACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGA
GTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCT
CTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCG
CCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTC
CTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTC

>68671_68671_6_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000399654_length(amino acids)=442AA_BP=196
MDPQERKEAATLAMASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDS
HDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQ
GNEGDNFYVVDQGEVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS
LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL

--------------------------------------------------------------
>68671_68671_7_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000402746_length(transcript)=1741nt_BP=724nt
AGTTTCTGCCGCCGCCACCCTGGCAGGATGGGGCAACGGTGTGCGGTAGGAGGATGAGGTTGATTCCCTTTCCTGCAGGGCTGGGCTTGT
GGGTTAGGACCGTCACCAAGAGGCTCCTCCTAGGCCTCCGTGACCTCTGGATCCCCAAGAAAGGAAGGAAGCAGCCACCCTCGCCATGGC
CTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAA
AGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAA
CAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAA
GGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTA
CAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGC
CATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGT
GGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCT
CAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCT
GCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCA
CAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGC
CGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGT
TTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCT
GACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGA
GTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCT
CTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCG
CCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTC
CTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTC

>68671_68671_7_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000402746_length(amino acids)=442AA_BP=196
MDPQERKEAATLAMASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDS
HDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQ
GNEGDNFYVVDQGEVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS
LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL

--------------------------------------------------------------
>68671_68671_8_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000406869_length(transcript)=1741nt_BP=724nt
AGTTTCTGCCGCCGCCACCCTGGCAGGATGGGGCAACGGTGTGCGGTAGGAGGATGAGGTTGATTCCCTTTCCTGCAGGGCTGGGCTTGT
GGGTTAGGACCGTCACCAAGAGGCTCCTCCTAGGCCTCCGTGACCTCTGGATCCCCAAGAAAGGAAGGAAGCAGCCACCCTCGCCATGGC
CTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGTGCAGCTGCACGGGATCCAGCAGGTCCTCAA
AGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGAGCACTTCGAGAAGCTGGAGAAGGAAGAAAA
CAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGTGTCGCCCACCCCCCCGAACCCTGTGGTGAA
GGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTCCTACGTCAGGAAGGTGATTCCCAAGGACTA
CAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGATGACAACGAGAGGAGTGACATATTCGATGC
CATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGACAACTTCTATGTCGTTGATCAAGGGGAAGT
GGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACGCT
CAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGCGAGCTCT
GCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGACCA
CAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTGAGGCTGC
CGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAGGT
TTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGTACCGGCT
GACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACAGA
GTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCCTCGAGCT
CTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCCTGCCCCG
CCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTCGGGCTTC
CTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGGGTTCCTC

>68671_68671_8_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000406797_MAD1L1_chr7_2020176_ENST00000406869_length(amino acids)=442AA_BP=196
MDPQERKEAATLAMASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDS
HDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQ
GNEGDNFYVVDQGEVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS
LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL

--------------------------------------------------------------
>68671_68671_9_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000265854_length(transcript)=1664nt_BP=664nt
CTCTGGCCGCTAAGGCAGAGTGAGACCCCAGGGAACGGGCGTGCTTGCTGGGTACCGGGTGTCCTGCAGAGGCAGGGATGTGATCCCCTA
GGTGAAGGAAGCAGCCACCCTCGCCATGGCCTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGT
GCAGCTGCACGGGATCCAGCAGGTCCTCAAAGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGA
GCACTTCGAGAAGCTGGAGAAGGAAGAAAACAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGT
GTCGCCCACCCCCCCGAACCCTGTGGTGAAGGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTC
CTACGTCAGGAAGGTGATTCCCAAGGACTACAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGA
TGACAACGAGAGGAGTGACATATTCGATGCCATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGA
CAACTTCTATGTCGTTGATCAAGGGGAAGTGGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTT
CCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGAT
GCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAG
TGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGG
AGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGC
CGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGAT
CGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTC
GGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCC
TGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTG
CTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTG
ACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGT

>68671_68671_9_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000265854_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_10_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000399654_length(transcript)=1681nt_BP=664nt
CTCTGGCCGCTAAGGCAGAGTGAGACCCCAGGGAACGGGCGTGCTTGCTGGGTACCGGGTGTCCTGCAGAGGCAGGGATGTGATCCCCTA
GGTGAAGGAAGCAGCCACCCTCGCCATGGCCTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGT
GCAGCTGCACGGGATCCAGCAGGTCCTCAAAGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGA
GCACTTCGAGAAGCTGGAGAAGGAAGAAAACAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGT
GTCGCCCACCCCCCCGAACCCTGTGGTGAAGGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTC
CTACGTCAGGAAGGTGATTCCCAAGGACTACAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGA
TGACAACGAGAGGAGTGACATATTCGATGCCATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGA
CAACTTCTATGTCGTTGATCAAGGGGAAGTGGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTT
CCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGAT
GCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAG
TGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGG
AGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGC
CGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGAT
CGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTC
GGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCC
TGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTG
CTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTG
ACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGT

>68671_68671_10_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000399654_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_11_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000402746_length(transcript)=1681nt_BP=664nt
CTCTGGCCGCTAAGGCAGAGTGAGACCCCAGGGAACGGGCGTGCTTGCTGGGTACCGGGTGTCCTGCAGAGGCAGGGATGTGATCCCCTA
GGTGAAGGAAGCAGCCACCCTCGCCATGGCCTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGT
GCAGCTGCACGGGATCCAGCAGGTCCTCAAAGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGA
GCACTTCGAGAAGCTGGAGAAGGAAGAAAACAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGT
GTCGCCCACCCCCCCGAACCCTGTGGTGAAGGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTC
CTACGTCAGGAAGGTGATTCCCAAGGACTACAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGA
TGACAACGAGAGGAGTGACATATTCGATGCCATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGA
CAACTTCTATGTCGTTGATCAAGGGGAAGTGGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTT
CCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGAT
GCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAG
TGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGG
AGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGC
CGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGAT
CGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTC
GGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCC
TGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTG
CTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTG
ACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGT

>68671_68671_11_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000402746_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------
>68671_68671_12_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000406869_length(transcript)=1681nt_BP=664nt
CTCTGGCCGCTAAGGCAGAGTGAGACCCCAGGGAACGGGCGTGCTTGCTGGGTACCGGGTGTCCTGCAGAGGCAGGGATGTGATCCCCTA
GGTGAAGGAAGCAGCCACCCTCGCCATGGCCTCCCCGCCCGCCTGCCCCTCGGAGGAGGACGAGAGCCTGAAGGGCTGTGAGCTGTACGT
GCAGCTGCACGGGATCCAGCAGGTCCTCAAAGACTGTATCGTCCACCTCTGCATCTCCAAGCCCGAACGCCCCATGAAGTTCCTCCGGGA
GCACTTCGAGAAGCTGGAGAAGGAAGAAAACAGGCAGATTTTGGCGCGGCAAAAGTCAAACTCACAGTCGGACTCCCATGATGAGGAGGT
GTCGCCCACCCCCCCGAACCCTGTGGTGAAGGCCCGCCGCCGGCGAGGAGGCGTGAGTGCCGAGGTGTACACCGAGGAGGACGCCGTGTC
CTACGTCAGGAAGGTGATTCCCAAGGACTACAAAACCATGACTGCGCTGGCCAAGGCCATCTCCAAGAACGTGCTCTTCGCTCACCTGGA
TGACAACGAGAGGAGTGACATATTCGATGCCATGTTCCCTGTCACTCACATCGCTGGGGAGACTGTTATACAGCAAGGGAATGAAGGAGA
CAACTTCTATGTCGTTGATCAAGGGGAAGTGGATCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTT
CCTGTTCTCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGAT
GCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAG
TGTGGCCAGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGG
AGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGC
CGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGAT
CGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTC
GGGTTCCAAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCC
TGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTG
CTTGGCCTGACCTGCAGGTCCCCTGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTG
ACAGACACGCTGGGACCTACGTCGGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGT

>68671_68671_12_PRKAR1B-MAD1L1_PRKAR1B_chr7_645830_ENST00000544935_MAD1L1_chr7_2020176_ENST00000406869_length(amino acids)=429AA_BP=183
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPV
VKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE
DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRKAR1B-MAD1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRKAR1B-MAD1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRKAR1B-MAD1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource