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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRKAR2A-USP4 (FusionGDB2 ID:68684)

Fusion Gene Summary for PRKAR2A-USP4

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAR2A-USP4
Fusion gene ID: 68684
HgeneTgene
Gene symbol

PRKAR2A

USP4

Gene ID

5576

7375

Gene nameprotein kinase cAMP-dependent type II regulatory subunit alphaubiquitin specific peptidase 4
SynonymsPKR2|PRKAR2UNP|Unph
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase regulatory subunit RII alphaprotein kinase A, RII-alpha subunitprotein kinase, cAMP-dependent, regulatory subunit type II alphaubiquitin carboxyl-terminal hydrolase 4deubiquitinating enzyme 4ubiquitin carboxyl-terminal esterase 4ubiquitin specific peptidase 4 (proto-oncogene)ubiquitin specific protease 4 (proto-oncogene)ubiquitin thioesterase 4ubiquitin thiolesterase 4ubiq
Modification date2020031320200313
UniProtAcc.

Q9H9J4

Ensembl transtripts involved in fusion geneENST00000265563, ENST00000296446, 
ENST00000454963, 		ENST00000415188, 
ENST00000416417, ENST00000488520, 
ENST00000265560, ENST00000351842, 
Fusion gene scores* DoF score11 X 7 X 7=5399 X 10 X 5=450
# samples 119
** MAII scorelog2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/450*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAR2A [Title/Abstract] AND USP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRKAR2A(48827977)-USP4(49362196), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR2A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984

TgeneUSP4

GO:0016579

protein deubiquitination

16316627|16339847|16472766

TgeneUSP4

GO:0031647

regulation of protein stability

16472766

TgeneUSP4

GO:0034394

protein localization to cell surface

16339847


check buttonFusion gene breakpoints across PRKAR2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-ZB-A96L-01APRKAR2Achr3

48827977

-USP4chr3

49362196

-


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Fusion Gene ORF analysis for PRKAR2A-USP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265563ENST00000415188PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000265563ENST00000416417PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000265563ENST00000488520PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000296446ENST00000415188PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000296446ENST00000416417PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000296446ENST00000488520PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000454963ENST00000415188PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000454963ENST00000416417PRKAR2Achr3

48827977

-USP4chr3

49362196

-
5CDS-intronENST00000454963ENST00000488520PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000265563ENST00000265560PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000265563ENST00000351842PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000296446ENST00000265560PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000296446ENST00000351842PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000454963ENST00000265560PRKAR2Achr3

48827977

-USP4chr3

49362196

-
In-frameENST00000454963ENST00000351842PRKAR2Achr3

48827977

-USP4chr3

49362196

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265563PRKAR2Achr348827977-ENST00000351842USP4chr349362196-32656852502802850
ENST00000265563PRKAR2Achr348827977-ENST00000265560USP4chr349362196-31316852502943897
ENST00000454963PRKAR2Achr348827977-ENST00000351842USP4chr349362196-32236432082760850
ENST00000454963PRKAR2Achr348827977-ENST00000265560USP4chr349362196-30896432082901897
ENST00000296446PRKAR2Achr348827977-ENST00000351842USP4chr349362196-32476672322784850
ENST00000296446PRKAR2Achr348827977-ENST00000265560USP4chr349362196-31136672322925897

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265563ENST00000351842PRKAR2Achr348827977-USP4chr349362196-0.0033177510.9966822
ENST00000265563ENST00000265560PRKAR2Achr348827977-USP4chr349362196-0.0044345130.9955655
ENST00000454963ENST00000351842PRKAR2Achr348827977-USP4chr349362196-0.0031767480.9968233
ENST00000454963ENST00000265560PRKAR2Achr348827977-USP4chr349362196-0.004319880.9956801
ENST00000296446ENST00000351842PRKAR2Achr348827977-USP4chr349362196-0.0032517930.9967482
ENST00000296446ENST00000265560PRKAR2Achr348827977-USP4chr349362196-0.0044161990.99558383

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Fusion Genomic Features for PRKAR2A-USP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKAR2A-USP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48827977/chr3:49362196)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.USP4

Q9H9J4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000265563-4112_138145405.0RegionNote=Dimerization and phosphorylation
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000454963-4122_138145423.0RegionNote=Dimerization and phosphorylation
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422302_923211964.0DomainUSP
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422483_571211964.0DomainUbiquitin-like 2
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421302_923211917.0DomainUSP
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421483_571211917.0DomainUbiquitin-like 2
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747302_923211314.0DomainUSP
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747483_571211314.0DomainUbiquitin-like 2
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422767_772211964.0MotifNuclear localization signal
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421767_772211917.0MotifNuclear localization signal
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747767_772211314.0MotifNuclear localization signal
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422229_295211964.0RegionRequired for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422485_775211964.0RegionInteracts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421229_295211917.0RegionRequired for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421485_775211917.0RegionInteracts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747229_295211314.0RegionRequired for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747485_775211314.0RegionInteracts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000265563-411139_260145405.0Nucleotide bindingNote=cAMP 1
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000265563-411261_404145405.0Nucleotide bindingNote=cAMP 2
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000454963-412139_260145423.0Nucleotide bindingNote=cAMP 1
HgenePRKAR2Achr3:48827977chr3:49362196ENST00000454963-412261_404145423.0Nucleotide bindingNote=cAMP 2
TgeneUSP4chr3:48827977chr3:49362196ENST0000026556042211_122211964.0DomainDUSP
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422142_226211964.0DomainUbiquitin-like 1
TgeneUSP4chr3:48827977chr3:49362196ENST0000035184242111_122211917.0DomainDUSP
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421142_226211917.0DomainUbiquitin-like 1
TgeneUSP4chr3:48827977chr3:49362196ENST000004164174711_122211314.0DomainDUSP
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747142_226211314.0DomainUbiquitin-like 1
TgeneUSP4chr3:48827977chr3:49362196ENST00000265560422133_141211964.0MotifNuclear export signal
TgeneUSP4chr3:48827977chr3:49362196ENST00000351842421133_141211917.0MotifNuclear export signal
TgeneUSP4chr3:48827977chr3:49362196ENST0000041641747133_141211314.0MotifNuclear export signal


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Fusion Gene Sequence for PRKAR2A-USP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68684_68684_1_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000265563_USP4_chr3_49362196_ENST00000265560_length(transcript)=3131nt_BP=685nt
AGCTCGCCTGCCCGTCGGTCCCCGCGGCGGCGGCGGCTGCCCAGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGC
GCGGCCCGGAAACGCAGAGCCGGCCAAAGAGCGGCGCGACGTGAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGC
CGGCGTGAGTGAGCGCGGAGACAGTGGCCGCCGGCGGCCCAACCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCC
GCCGGGGCTCACGGAGCTGCTGCAGGGCTACACGGTGGAGGTGCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTT
CACCCGCCTGCGCGAGGCCCGCGCCCCAGCCTCAGTCCTGCCCGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGG
CCCGGACCGTGTCGCCGACGCCAAAGGGGACAGCGAGTCGGAGGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACG
AGTATCAGTCTGTGCTGAGACCTATAACCCTGATGAGGAAGAGGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAG
ATGCAGACTTCAGGAAGCTTGCAAAGATATTCTCCTTTTCAAAAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCAC
ATGGCCCAGGCAGACCTTGCAGTCAAAATCAAGCACTGCGCCTAGCAGAAATTTTACTACCTCTCCAAAATCATCAGCAAGTCCCTATTC
CTCAGTGTCTGCCTCTCTCATTGCAAATGGTGATAGCACTAGCACCTGTGGGATGCACAGTTCCGGTGTCAGCAGGGGTGGATCTGGCTT
TTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCAT
GAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAA
CCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCG
CATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGA
TGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAA
GGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGA
ATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCT
GGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTC
CAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTT
AAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTA
CTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAA
GTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACC
CTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCA
GCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCC
AAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAA
CTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGT
GAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGA
GCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGT
CCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGA
GTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACAC
TGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAA
AGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGAC
ACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCT
GTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTT

>68684_68684_1_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000265563_USP4_chr3_49362196_ENST00000265560_length(amino acids)=897AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPK
SSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYE
AEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGR
PDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVS
DLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLL
LSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKK
IKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFT
TMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGA

--------------------------------------------------------------
>68684_68684_2_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000265563_USP4_chr3_49362196_ENST00000351842_length(transcript)=3265nt_BP=685nt
AGCTCGCCTGCCCGTCGGTCCCCGCGGCGGCGGCGGCTGCCCAGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGC
GCGGCCCGGAAACGCAGAGCCGGCCAAAGAGCGGCGCGACGTGAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGC
CGGCGTGAGTGAGCGCGGAGACAGTGGCCGCCGGCGGCCCAACCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCC
GCCGGGGCTCACGGAGCTGCTGCAGGGCTACACGGTGGAGGTGCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTT
CACCCGCCTGCGCGAGGCCCGCGCCCCAGCCTCAGTCCTGCCCGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGG
CCCGGACCGTGTCGCCGACGCCAAAGGGGACAGCGAGTCGGAGGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACG
AGTATCAGTCTGTGCTGAGACCTATAACCCTGATGAGGAAGAGGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAG
ATGCAGACTTCAGGAAGCTTGCAAAGATATTCTCCTTTTCAAAAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCAC
ATGGCCCAGGCAGACCTTGCAGTCAAATGGATCTGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGG
GCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTT
TCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAA
GCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCA
GCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCT
GAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATAC
TTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCC
ACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCC
GCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAA
TCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCAC
TTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCT
ATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTA
TGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGA
TGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAG
TGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACAT
AAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTA
CTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGA
CTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAA
AAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACAC
AGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGT
GTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAG
CAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGAC
ACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCAT
GGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTG
CTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTTACCTAG
AAGAAGCTATGTCAAGAGGCTGAATTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGGGGGTGG
GATGGGGGTACTCAATGGAGTATGTCTGATGGATCCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACC
CCACCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTGATGCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACCCAAACC

>68684_68684_2_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000265563_USP4_chr3_49362196_ENST00000351842_length(amino acids)=850AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPP
SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFA
PQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDP
FCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIF
VYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSR
NSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWD
SETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY
WRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR

--------------------------------------------------------------
>68684_68684_3_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000296446_USP4_chr3_49362196_ENST00000265560_length(transcript)=3113nt_BP=667nt
TCCCCGCGGCGGCGGCGGCTGCCCAGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGCGCGGCCCGGAAACGCAGA
GCCGGCCAAAGAGCGGCGCGACGTGAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGCCGGCGTGAGTGAGCGCGG
AGACAGTGGCCGCCGGCGGCCCAACCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCCGCCGGGGCTCACGGAGCT
GCTGCAGGGCTACACGGTGGAGGTGCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTTCACCCGCCTGCGCGAGGC
CCGCGCCCCAGCCTCAGTCCTGCCCGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGGCCCGGACCGTGTCGCCGA
CGCCAAAGGGGACAGCGAGTCGGAGGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACGAGTATCAGTCTGTGCTGA
GACCTATAACCCTGATGAGGAAGAGGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAGATGCAGACTTCAGGAAGC
TTGCAAAGATATTCTCCTTTTCAAAAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTT
GCAGTCAAAATCAAGCACTGCGCCTAGCAGAAATTTTACTACCTCTCCAAAATCATCAGCAAGTCCCTATTCCTCAGTGTCTGCCTCTCT
CATTGCAAATGGTGATAGCACTAGCACCTGTGGGATGCACAGTTCCGGTGTCAGCAGGGGTGGATCTGGCTTTTCTGCTTCGTATAATTG
TCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTG
TTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGG
GGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGT
AGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCT
GAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCA
CAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGAATGTGCTAAGGTTTCTGT
GACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCA
CTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGC
TGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCG
GGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTC
CAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTT
GTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTG
CAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGG
CAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTT
CAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGC
CATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCA
GAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTG
TCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTC
CTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTC
AGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAA
ACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATT
TTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCA
GCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCC
CCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGA

>68684_68684_3_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000296446_USP4_chr3_49362196_ENST00000265560_length(amino acids)=897AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPK
SSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYE
AEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGR
PDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVS
DLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLL
LSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKK
IKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFT
TMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGA

--------------------------------------------------------------
>68684_68684_4_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000296446_USP4_chr3_49362196_ENST00000351842_length(transcript)=3247nt_BP=667nt
TCCCCGCGGCGGCGGCGGCTGCCCAGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGCGCGGCCCGGAAACGCAGA
GCCGGCCAAAGAGCGGCGCGACGTGAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGCCGGCGTGAGTGAGCGCGG
AGACAGTGGCCGCCGGCGGCCCAACCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCCGCCGGGGCTCACGGAGCT
GCTGCAGGGCTACACGGTGGAGGTGCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTTCACCCGCCTGCGCGAGGC
CCGCGCCCCAGCCTCAGTCCTGCCCGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGGCCCGGACCGTGTCGCCGA
CGCCAAAGGGGACAGCGAGTCGGAGGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACGAGTATCAGTCTGTGCTGA
GACCTATAACCCTGATGAGGAAGAGGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAGATGCAGACTTCAGGAAGC
TTGCAAAGATATTCTCCTTTTCAAAAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTT
GCAGTCAAATGGATCTGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAA
CCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGA
AGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAG
GGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGA
GCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCG
GCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAA
ATCTACTTTGGTTTGCCCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGA
TCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTC
CGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAAT
TTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGA
ATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATT
GCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACC
TGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCA
TCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAA
GATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGA
TGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATC
TGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCAC
CACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTC
CTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAAT
CAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGC
CATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTC
TGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTC
TGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTG
ACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAA
ACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAG
GCTGAATTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGGGGGTGGGATGGGGGTACTCAATGG
AGTATGTCTGATGGATCCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCACCTGCAGGGCTGCCC
TGAGCGCCTGGATTTCTGGTTCTGATGCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACCCAAACCTCAAGTAAACTCCCCTTT

>68684_68684_4_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000296446_USP4_chr3_49362196_ENST00000351842_length(amino acids)=850AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPP
SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFA
PQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDP
FCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIF
VYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSR
NSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWD
SETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY
WRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR

--------------------------------------------------------------
>68684_68684_5_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000454963_USP4_chr3_49362196_ENST00000265560_length(transcript)=3089nt_BP=643nt
AGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGCGCGGCCCGGAAACGCAGAGCCGGCCAAAGAGCGGCGCGACGT
GAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGCCGGCGTGAGTGAGCGCGGAGACAGTGGCCGCCGGCGGCCCAA
CCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCCGCCGGGGCTCACGGAGCTGCTGCAGGGCTACACGGTGGAGGT
GCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTTCACCCGCCTGCGCGAGGCCCGCGCCCCAGCCTCAGTCCTGCC
CGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGGCCCGGACCGTGTCGCCGACGCCAAAGGGGACAGCGAGTCGGA
GGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACGAGTATCAGTCTGTGCTGAGACCTATAACCCTGATGAGGAAGA
GGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAGATGCAGACTTCAGGAAGCTTGCAAAGATATTCTCCTTTTCAA
AAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTTGCAGTCAAAATCAAGCACTGCGCC
TAGCAGAAATTTTACTACCTCTCCAAAATCATCAGCAAGTCCCTATTCCTCAGTGTCTGCCTCTCTCATTGCAAATGGTGATAGCACTAG
CACCTGTGGGATGCACAGTTCCGGTGTCAGCAGGGGTGGATCTGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATAT
ACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGAC
TGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGA
ACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTC
TGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTA
CTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGAT
TGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCT
AACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGT
GACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGA
TGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGT
CTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGC
ATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTAT
CAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGA
AGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAA
TGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAAC
AGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCG
GAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGC
CCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACA
GGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAA
GCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCT
CATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTT
TGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATT
TTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGC
TTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTC
TGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCG

>68684_68684_5_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000454963_USP4_chr3_49362196_ENST00000265560_length(amino acids)=897AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPK
SSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYE
AEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGR
PDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVS
DLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLL
LSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKK
IKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFT
TMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGA

--------------------------------------------------------------
>68684_68684_6_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000454963_USP4_chr3_49362196_ENST00000351842_length(transcript)=3223nt_BP=643nt
AGTGACAGCGGCGGCGGTGCCAGGTCGGCCGTGGTAGCGTAGGGTTGCGCGGCCCGGAAACGCAGAGCCGGCCAAAGAGCGGCGCGACGT
GAGCCGGGGCCGTGCGCGAAGAGACCTCGCGGGCGCGGAGCGAAAGGCCGGCGTGAGTGAGCGCGGAGACAGTGGCCGCCGGCGGCCCAA
CCCGTCTATCCCTTCGGCCGCCGCCGGCATGAGCCACATCCAGATCCCGCCGGGGCTCACGGAGCTGCTGCAGGGCTACACGGTGGAGGT
GCTGCGACAGCAGCCGCCTGACCTCGTCGAATTCGCAGTGGAGTACTTCACCCGCCTGCGCGAGGCCCGCGCCCCAGCCTCAGTCCTGCC
CGCCGCCACCCCACGCCAGAGCCTGGGCCACCCCCCGCCAGAACCCGGCCCGGACCGTGTCGCCGACGCCAAAGGGGACAGCGAGTCGGA
GGAGGACGAGGACTTGGAAGTTCCAGTTCCTAGCAGATTTAATAGACGAGTATCAGTCTGTGCTGAGACCTATAACCCTGATGAGGAAGA
GGAAGATACAGATCCAAGGGTGATTCATCCTAAAACTGATGAACAGAGATGCAGACTTCAGGAAGCTTGCAAAGATATTCTCCTTTTCAA
AAATCTTGATCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTTGCAGTCAAATGGATCTGGCTTTTC
TGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAA
CTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCC
TCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCAT
GTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGG
ATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGA
AGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGAATG
TGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGT
TCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAG
GCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAA
CCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTT
CAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTT
AACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTT
GGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCT
TTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAA
AAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTC
TCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAG
CATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCA
TGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCA
CCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTT
TGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGC
ATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGC
AGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACG
ACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTA
GCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTT
TTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAGGCTGAATTATTTTTATTTTTAAAC
AGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGGGGGTGGGATGGGGGTACTCAATGGAGTATGTCTGATGGATCCCGAAGA
ATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCACCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTG

>68684_68684_6_PRKAR2A-USP4_PRKAR2A_chr3_48827977_ENST00000454963_USP4_chr3_49362196_ENST00000351842_length(amino acids)=850AA_BP=144
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV
PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPP
SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFA
PQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDP
FCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIF
VYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSR
NSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWD
SETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY
WRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR

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Fusion Gene PPI Analysis for PRKAR2A-USP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRKAR2A-USP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRKAR2A-USP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource