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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PRKAR2B-HMCN1 (FusionGDB2 ID:68685) |
Fusion Gene Summary for PRKAR2B-HMCN1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PRKAR2B-HMCN1 | Fusion gene ID: 68685 | Hgene | Tgene | Gene symbol | PRKAR2B | HMCN1 | Gene ID | 5577 | 83872 |
Gene name | protein kinase cAMP-dependent type II regulatory subunit beta | hemicentin 1 | |
Synonyms | PRKAR2|RII-BETA | ARMD1|FBLN6|FIBL-6|FIBL6 | |
Cytomap | 7q22.3 | 1q25.3-q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-dependent protein kinase type II-beta regulatory subunitH_RG363E19.2WUGSC:H_RG363E19.2cAMP-dependent protein kinase type II-beta regulatory chainprotein kinase, cAMP-dependent, regulatory subunit type II betaprotein kinase, cAMP-dependent, regul | hemicentin-1LOC100507250/HMCN1 fusionfibulin-6 | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | . | Q96RW7 | |
Ensembl transtripts involved in fusion gene | ENST00000393613, ENST00000265717, | ENST00000271588, ENST00000367492, ENST00000485744, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 11 X 10 X 5=550 |
# samples | 2 | 12 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/550*10)=-2.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PRKAR2B [Title/Abstract] AND HMCN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PRKAR2B(106710761)-HMCN1(185815158), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKAR2B | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
Fusion gene breakpoints across PRKAR2B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across HMCN1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-22-4593-01A | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
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Fusion Gene ORF analysis for PRKAR2B-HMCN1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000393613 | ENST00000271588 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
3UTR-3CDS | ENST00000393613 | ENST00000367492 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
3UTR-intron | ENST00000393613 | ENST00000485744 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
5CDS-intron | ENST00000265717 | ENST00000485744 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
In-frame | ENST00000265717 | ENST00000271588 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
In-frame | ENST00000265717 | ENST00000367492 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000265717 | PRKAR2B | chr7 | 106710761 | - | ENST00000271588 | HMCN1 | chr1 | 185815158 | + | 18313 | 602 | 259 | 17241 | 5660 |
ENST00000265717 | PRKAR2B | chr7 | 106710761 | - | ENST00000367492 | HMCN1 | chr1 | 185815158 | + | 17966 | 602 | 259 | 16890 | 5543 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000265717 | ENST00000271588 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + | 0.000286558 | 0.99971336 |
ENST00000265717 | ENST00000367492 | PRKAR2B | chr7 | 106710761 | - | HMCN1 | chr1 | 185815158 | + | 0.000671344 | 0.99932873 |
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Fusion Genomic Features for PRKAR2B-HMCN1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PRKAR2B-HMCN1 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:106710761/chr1:185815158) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | HMCN1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. {ECO:0000250|UniProtKB:D3YXG0}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1072_1166 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 8 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1171_1255 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 9 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1262_1354 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 10 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1358_1447 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 11 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1452_1541 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 12 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1546_1634 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 13 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1638_1724 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 14 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1733_1821 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 15 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1826_1914 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 16 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 1919_2007 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 17 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2012_2097 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 18 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2104_2190 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 19 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2195_2285 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 20 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2290_2379 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 21 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2384_2470 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 22 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2478_2564 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 23 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2571_2662 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 24 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2666_2763 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 25 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2766_2864 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 26 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2868_2959 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 27 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 2964_3051 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 28 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3056_3146 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 29 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3151_3240 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 30 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3245_3335 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 31 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3340_3429 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 32 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3434_3516 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 33 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3527_3615 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 34 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3620_3708 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 35 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3713_3797 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 36 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3804_3892 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 37 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3897_3983 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 38 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 3988_4076 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 39 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4079_4164 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 40 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4169_4255 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 41 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4260_4344 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 42 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 431_517 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 1 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4348_4435 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 43 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4440_4527 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 44 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4529_4584 | 89 | 5636.0 | Domain | TSP type-1 1 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4586_4641 | 89 | 5636.0 | Domain | TSP type-1 2 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4643_4698 | 89 | 5636.0 | Domain | TSP type-1 3 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4700_4755 | 89 | 5636.0 | Domain | TSP type-1 4 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4757_4812 | 89 | 5636.0 | Domain | TSP type-1 5 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4814_4869 | 89 | 5636.0 | Domain | TSP type-1 6 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 4871_5093 | 89 | 5636.0 | Domain | Nidogen G2 beta-barrel | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5107_5146 | 89 | 5636.0 | Domain | EGF-like 1%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5147_5191 | 89 | 5636.0 | Domain | EGF-like 2%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5192_5229 | 89 | 5636.0 | Domain | EGF-like 3%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 520_607 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 2 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5230_5271 | 89 | 5636.0 | Domain | EGF-like 4%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5272_5307 | 89 | 5636.0 | Domain | EGF-like 5%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5315_5355 | 89 | 5636.0 | Domain | EGF-like 6%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 5432_5471 | 89 | 5636.0 | Domain | EGF-like 7%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 612_697 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 3 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 702_788 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 4 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 793_883 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 5 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 890_976 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 6 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 981_1067 | 89 | 5636.0 | Domain | Note=Ig-like C2-type 7 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1072_1166 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 8 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1171_1255 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 9 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1262_1354 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 10 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1358_1447 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 11 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1452_1541 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 12 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1546_1634 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 13 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1638_1724 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 14 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1733_1821 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 15 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1826_1914 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 16 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 1919_2007 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 17 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2012_2097 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 18 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2104_2190 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 19 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2195_2285 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 20 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2290_2379 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 21 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2384_2470 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 22 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2478_2564 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 23 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2571_2662 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 24 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2666_2763 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 25 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2766_2864 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 26 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2868_2959 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 27 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 2964_3051 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 28 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3056_3146 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 29 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3151_3240 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 30 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3245_3335 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 31 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3340_3429 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 32 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3434_3516 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 33 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3527_3615 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 34 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3620_3708 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 35 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3713_3797 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 36 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3804_3892 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 37 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3897_3983 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 38 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 3988_4076 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 39 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4079_4164 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 40 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4169_4255 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 41 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4260_4344 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 42 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 431_517 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 1 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4348_4435 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 43 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4440_4527 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 44 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4529_4584 | 89 | 5519.0 | Domain | TSP type-1 1 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4586_4641 | 89 | 5519.0 | Domain | TSP type-1 2 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4643_4698 | 89 | 5519.0 | Domain | TSP type-1 3 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4700_4755 | 89 | 5519.0 | Domain | TSP type-1 4 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4757_4812 | 89 | 5519.0 | Domain | TSP type-1 5 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4814_4869 | 89 | 5519.0 | Domain | TSP type-1 6 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 4871_5093 | 89 | 5519.0 | Domain | Nidogen G2 beta-barrel | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5107_5146 | 89 | 5519.0 | Domain | EGF-like 1%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5147_5191 | 89 | 5519.0 | Domain | EGF-like 2%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5192_5229 | 89 | 5519.0 | Domain | EGF-like 3%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 520_607 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 2 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5230_5271 | 89 | 5519.0 | Domain | EGF-like 4%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5272_5307 | 89 | 5519.0 | Domain | EGF-like 5%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5315_5355 | 89 | 5519.0 | Domain | EGF-like 6%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 5432_5471 | 89 | 5519.0 | Domain | EGF-like 7%3B calcium-binding | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 612_697 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 3 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 702_788 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 4 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 793_883 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 5 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 890_976 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 6 | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 981_1067 | 89 | 5519.0 | Domain | Note=Ig-like C2-type 7 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PRKAR2B | chr7:106710761 | chr1:185815158 | ENST00000265717 | - | 2 | 11 | 154_275 | 114 | 419.0 | Nucleotide binding | Note=cAMP 1 |
Hgene | PRKAR2B | chr7:106710761 | chr1:185815158 | ENST00000265717 | - | 2 | 11 | 276_418 | 114 | 419.0 | Nucleotide binding | Note=cAMP 2 |
Hgene | PRKAR2B | chr7:106710761 | chr1:185815158 | ENST00000265717 | - | 2 | 11 | 2_153 | 114 | 419.0 | Region | Note=Dimerization and phosphorylation |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000271588 | 0 | 107 | 41_216 | 89 | 5636.0 | Domain | Note=VWFA | |
Tgene | HMCN1 | chr7:106710761 | chr1:185815158 | ENST00000367492 | 0 | 106 | 41_216 | 89 | 5519.0 | Domain | Note=VWFA |
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Fusion Gene Sequence for PRKAR2B-HMCN1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>68685_68685_1_PRKAR2B-HMCN1_PRKAR2B_chr7_106710761_ENST00000265717_HMCN1_chr1_185815158_ENST00000271588_length(transcript)=18313nt_BP=602nt GCCGCGGCTGGAGCGGGAGGAGCAGGAGATGCTGCCAGCCCTCCCGGGGCCGCGCTCGCTCAGCCGCCGCCACCACACGGAGCAGACGCG CGCCGGGAGCCGCGGGCCGGGCCAGCCGGGCCGCCGGGGCCCAGTGCGCCGCGCTCGCAGCCGGTAGCGCGCCAGCGCCGTAGGCGCTCG CTCGGCAGCCGCGGGGCCCTAGGCCGTGCCGGGGAGGGGGCGAGGGCGGCGCCCAGGCGCCTGCCGCCCCGGAGGCAGGATGAGCATCGA GATCCCGGCGGGACTGACGGAGCTGCTGCAGGGCTTCACGGTGGAGGTGCTGAGGCACCAGCCCGCGGACCTGCTGGAGTTCGCGCTGCA GCACTTCACCCGCCTGCAGCAGGAGAACGAGCGCAAAGGCACCGCGCGCTTCGGCCATGAGGGCAGGACCTGGGGGGACCTGGGCGCCGC TGCCGGGGGCGGCACCCCCAGCAAGGGGGTCAACTTCGCCGAGGAGCCCATGCAGTCCGACTCCGAGGACGGGGAGGAGGAGGAGGCGGC GCCCGCGGACGCAGGGGCGTTCAATGCTCCAGTAATAAACCGATTCACAAGGCGTGCCTCAGAAATTGGCCCAGTGACAATTACCACAGA TCCCAAGAAATTTCAATATGAACTCAGAGAACTGTATGTTCAGGGTGGTGGTGATTGCCCAGAAATGAGTATTGGAGCTATAAAAATTGC CTTGGAAATTTCTCTTCCTGGTTCTTTCATCTATGTTTTCACTGATGCTCGGTCCAAAGATTACCGGCTCACCCATGAGGTGCTGCAACT TATCCAACAGAAACAGTCACAAGTCGTATTTGTTCTGACTGGAGATTGTGATGACAGGACCCATATTGGATATAAAGTCTATGAAGAAAT TGCCTCTACAAGTTCTGGTCAAGTGTTCCATCTGGACAAAAAACAAGTTAATGAGGTATTAAAATGGGTAGAAGAAGCAGTACAGGCCTC CAAAGTTCACCTTTTATCCACAGATCATTTGGAACAGGCTGTAAATACTTGGAGAATTCCTTTTGATCCCAGCCTGAAAGAGGTCACTGT GTCTTTGAGTGGGCCTTCTCCAATGATTGAAATTCGCAATCCTTTAGGGAAGCTGATAAAAAAGGGATTTGGCCTGCATGAGCTATTAAA TATCCATAACTCTGCCAAAGTAGTGAATGTGAAAGAGCCAGAGGCTGGAATGTGGACAGTGAAGACCTCAAGCAGTGGAAGGCACTCTGT TCGCATTACTGGCCTCAGTACTATTGATTTCCGAGCTGGCTTTTCTCGAAAGCCCACCCTGGACTTCAAAAAAACAGTCAGCAGACCAGT GCAAGGAATACCTACCTATGTACTGCTCAATACTTCTGGAATTTCCACTCCAGCTAGAATAGATCTTCTTGAACTTTTGAGTATCTCAGG AAGTTCTCTTAAGACTATTCCTGTTAAATATTACCCACATCGAAAACCTTATGGCATATGGAATATTTCTGACTTTGTACCACCAAATGA AGCTTTCTTTCTCAAAGTAACAGGCTATGATAAAGATGATTACCTCTTCCAGAGAGTATCAAGTGTTTCCTTTTCTAGTATTGTCCCAGA TGCTCCCAAAGTTACGATGCCTGAGAAAACCCCAGGATACTATCTGCAGCCGGGCCAAATTCCCTGCTCTGTTGACAGTCTTTTGCCCTT TACCTTGAGCTTTGTCAGAAATGGAGTTACACTTGGAGTAGACCAGTATTTGAAAGAATCTGCCAGTGTGAACTTAGATATTGCAAAGGT CACTTTGTCTGACGAAGGTTTCTATGAATGCATTGCTGTCAGCAGTGCAGGTACTGGACGGGCACAGACATTTTTTGACGTATCAGAGCC CCCTCCGGTCATCCAAGTGCCTAACAATGTTACAGTCACTCCTGGAGAGAGAGCAGTTTTAACATGTCTCATCATCAGTGCGGTGGATTA CAATCTAACCTGGCAGAGGAATGACAGAGATGTCAGACTGGCAGAGCCAGCGAGAATTAGGACCTTGGCTAATCTGTCATTGGAGCTAAA GAGTGTGAAATTCAACGATGCTGGAGAGTATCATTGTATGGTTTCTAGTGAAGGTGGATCATCAGCCGCTTCAGTTTTCCTCACAGTGCA AGAACCACCCAAAGTCACTGTGATGCCCAAGAATCAGTCTTTCACAGGAGGGTCTGAGGTCTCCATCATGTGTTCTGCAACAGGTTATCC CAAACCAAAGATTGCCTGGACCGTTAACGATATGTTTATCGTGGGTTCACACAGGTATAGGATGACCTCAGATGGTACCTTATTTATCAA AAATGCAGCTCCCAAAGATGCAGGGATCTATGGTTGCCTAGCAAGTAATTCAGCTGGAACAGATAAACAGAATTCTACTCTCAGATACAT TGAAGCCCCTAAGTTGATGGTAGTTCAGAGTGAGCTCTTGGTTGCCCTTGGGGATATAACCGTTATGGAATGCAAAACCTCTGGTATTCC TCCACCTCAAGTTAAATGGTTCAAAGGAGATCTTGAGTTGAGGCCCTCAACATTCCTCATTATTGACCCTCTCTTGGGACTTTTGAAGAT TCAAGAAACACAAGATCTGGATGCTGGCGATTATACCTGTGTAGCCATCAATGAGGCTGGAAGAGCAACTGGCAAGATAACTCTGGATGT TGGCTCACCTCCAGTTTTCATACAAGAACCTGCTGATGTGTCTATGGAAATTGGCTCAAATGTGACATTACCTTGTTATGTTCAGGGTTA TCCAGAACCAACAATCAAATGGCGAAGATTAGACAACATGCCAATTTTCTCAAGACCTTTTTCAGTTAGTTCCATCAGCCAACTAAGAAC AGGAGCTCTCTTTATTTTAAACTTATGGGCAAGTGATAAAGGAACCTATATTTGTGAAGCTGAAAACCAGTTTGGAAAGATCCAGTCAGA GACAACAGTAACAGTGACCGGACTTGTTGCTCCACTTATTGGAATCAGCCCTTCAGTGGCCAATGTTATTGAAGGACAGCAGCTTACTTT GCCCTGTACTCTGTTAGCTGGAAATCCCATTCCAGAACGTCGGTGGATTAAGAATTCAGCTATGTTGCTCCAAAATCCTTACATCACTGT GCGCAGTGATGGGAGCCTCCATATTGAAAGAGTTCAGCTTCAGGATGGTGGTGAATATACTTGTGTGGCCAGTAACGTTGCTGGGACCAA TAACAAAACTACCTCTGTGGTTGTGCATGTTCTGCCAACCATTCAGCATGGGCAGCAGATACTCAGTACAATTGAAGGCATTCCAGTAAC TTTACCATGCAAAGCAAGTGGAAATCCCAAACCGTCTGTCATCTGGTCCAAGAAAGGAGAGCTGATTTCAACCAGCAGTGCTAAGTTTTC AGCAGGAGCTGATGGTAGTCTGTATGTGGTATCACCTGGAGGAGAGGAGAGTGGGGAGTATGTCTGCACTGCCACCAATACAGCCGGCTA CGCCAAAAGGAAAGTGCAGCTAACAGTCTATGTAAGGCCCAGAGTGTTTGGAGATCAACGAGGACTGTCCCAGGATAAGCCTGTTGAGAT CTCCGTCCTTGCAGGGGAAGAGGTAACACTTCCATGTGAAGTGAAGAGCTTACCTCCACCCATAATTACTTGGGCCAAAGAAACCCAGCT CATCTCACCGTTCTCTCCAAGACACACATTCCTCCCTTCTGGTTCAATGAAGATCACTGAAACCCGCACTTCAGATAGTGGGATGTATCT TTGTGTTGCCACAAATATTGCTGGGAATGTGACTCAGGCTGTCAAATTAAATGTCCATGTTCCTCCAAAGATACAGCGTGGACCTAAACA TCTCAAAGTCCAAGTTGGTCAAAGAGTGGATATTCCATGTAATGCTCAAGGGACTCCTCTTCCTGTAATCACCTGGTCCAAAGGTGGAAG CACTATGCTGGTTGATGGAGAGCACCATGTTAGCAATCCAGACGGAACTTTAAGCATCGACCAAGCCACGCCCTCAGATGCTGGCATATA TACATGTGTTGCTACTAACATAGCAGGCACTGATGAAACAGAGATAACGCTACATGTCCAAGAACCACCCACAGTGGAAGATCTAGAACC TCCATATAACACTACTTTCCAAGAAAGAGTGGCCAATCAACGCATTGAATTTCCATGTCCTGCAAAAGGTACCCCTAAACCAACCATCAA ATGGTTACACAATGGTAGAGAGTTGACAGGCAGAGAGCCTGGCATTTCTATCTTGGAAGATGGCACATTGCTGGTTATTGCTTCTGTTAC ACCCTATGACAATGGGGAGTACATCTGTGTGGCAGTCAATGAAGCTGGAACCACAGAAAGAAAATATAACCTCAAAGTCCATGTTCCTCC AGTAATTAAAGATAAAGAACAAGTTACAAATGTGTCGGTGTTGTTAAATCAGCTGACCAATCTCTTCTGTGAAGTGGAAGGCACTCCATC TCCCATCATTATGTGGTATAAAGATAATGTCCAGGTGACTGAAAGCAGCACTATTCAGACTGTGAACAATGGGAAGATACTGAAGCTCTT CAGAGCCACTCCAGAGGATGCAGGAAGATATTCCTGCAAAGCAATTAATATTGCAGGCACTTCTCAGAAGTACTTTAACATTGATGTGCT AGTTCCACCCACCATAATAGGTACCAACTTCCCAAATGAAGTCTCAGTTGTCCTCAACCGTGACGTCGCCCTTGAATGCCAGGTCAAAGG CACTCCCTTTCCTGATATTCATTGGTTCAAAGATGGCAAGCCTTTATTTTTGGGCGATCCTAATGTTGAACTTCTAGACAGAGGACAAGT CTTACATTTAAAGAATGCACGGAGAAATGACAAGGGGCGCTACCAATGTACTGTGTCTAATGCAGCTGGCAAACAAGCCAAGGATATAAA ACTGACTATCTATATTCCACCTAGTATTAAAGGAGGAAATGTCACCACAGACATATCAGTATTGATCAACAGCCTTATTAAACTGGAATG TGAAACACGGGGACTTCCAATGCCTGCCATTACTTGGTATAAGGACGGGCAGCCAATCATGTCCAGCTCACAAGCACTTTATATTGATAA AGGACAATATCTTCATATTCCTCGAGCACAGGTCTCTGATTCAGCAACATATACGTGTCATGTAGCCAATGTTGCTGGAACTGCTGAAAA ATCATTCCATGTGGATGTCTATGTTCCTCCAATGATTGAAGGCAACTTGGCCACGCCTTTGAATAAGCAAGTAGTTATTGCTCATTCTCT GACACTGGAGTGCAAAGCTGCTGGAAACCCTTCTCCCATTCTCACCTGGTTGAAAGATGGTGTACCTGTGAAAGCTAATGACAATATCCG CATAGAAGCTGGTGGGAAGAAACTCGAAATCATGAGTGCCCAAGAAATTGATCGAGGACAGTACATATGCGTGGCTACCAGTGTGGCAGG AGAAAAGGAAATCAAATATGAAGTTGATGTCTTGGTGCCACCAGCTATAGAAGGAGGAGATGAAACATCTTACTTCATTGTGATGGTTAA TAACTTACTGGAGCTAGATTGTCATGTGACAGGCTCTCCCCCACCAACTATCATGTGGCTGAAGGATGGCCAGTTAATTGATGAAAGGGA TGGATTCAAGATTTTATTAAATGGACGCAAACTGGTTATTGCTCAGGCTCAAGTGTCAAACACAGGCCTTTATCGGTGCATGGCAGCAAA TACTGCTGGAGACCACAAGAAGGAATTTGAAGTGACTGTTCATGTTCCTCCAACAATCAAGTCCTCAGGCCTTTCTGAGAGAGTTGTGGT AAAATACAAGCCTGTCGCCTTGCAGTGCATAGCCAATGGGATTCCAAATCCTTCCATTACATGGTTAAAAGATGACCAGCCTGTGAACAC TGCCCAAGGAAACCTTAAAATACAGTCTTCTGGTCGAGTTCTACAAATTGCCAAAACCCTGTTGGAAGATGCTGGCAGATACACATGTGT GGCTACCAACGCAGCTGGAGAAACACAACAGCACATTCAACTGCATGTTCATGAACCACCTAGTCTGGAAGATGCTGGAAAAATGCTGAA TGAGACTGTGTTGGTGAGCAACCCTGTACAGCTGGAGTGTAAGGCAGCTGGAAATCCTGTGCCTGTTATTACATGGTACAAAGATAATCG TCTACTCTCAGGTTCCACCAGCATGACTTTCTTGAACAGAGGACAGATCATTGATATTGAAAGTGCCCAGATCTCAGATGCTGGCATATA TAAATGCGTGGCCATCAACTCAGCTGGAGCTACAGAGTTATTTTACAGTCTGCAAGTTCATGTGGCCCCATCAATTTCTGGCAGCAATAA CATGGTGGCAGTGGTGGTTAATAACCCGGTGAGGTTAGAATGTGAAGCCAGAGGTATTCCTGCCCCAAGTCTGACCTGGTTGAAAGATGG GAGTCCTGTTTCTAGTTTTTCTAATGGATTACAGGTTCTCTCTGGTGGTCGAATCCTAGCATTGACCAGTGCACAAATCAGCGACACAGG AAGGTACACCTGCGTGGCAGTGAATGCTGCTGGAGAAAAGCAAAGGGACATTGACCTCCGAGTATATGTTCCGCCAAATATTATGGGAGA AGAACAGAATGTCTCTGTCCTCATTAGCCAAGCTGTGGAATTACTATGTCAAAGTGATGCTATTCCCCCACCTACTCTTACTTGGTTAAA AGACGGCCACCCCTTGCTGAAGAAACCAGGCCTCAGTATATCTGAAAATAGAAGTGTGTTAAAGATTGAAGATGCTCAGGTTCAAGACAC TGGTCGTTACACTTGTGAAGCAACAAATGTTGCTGGAAAAACTGAAAAAAACTACAATGTCAACATTTGGGTCCCCCCAAATATTGGTGG TTCTGATGAACTTACTCAACTTACAGTCATTGAAGGGAATCTCATTAGTCTGTTGTGTGAATCAAGTGGTATTCCACCCCCAAATCTCAT CTGGAAGAAGAAAGGCTCTCCAGTGCTGACTGATTCCATGGGGCGAGTTAGAATTTTATCTGGGGGCAGGCAATTACAAATTTCAATTGC TGAAAAGTCTGATGCAGCACTCTATTCATGTGTGGCGTCGAATGTTGCTGGGACTGCAAAGAAAGAATACAATCTGCAAGTTTACATTAG ACCAACCATAACCAACAGTGGCAGCCACCCTACTGAAATTATTGTGACCCGAGGGAAGAGTATCTCCTTGGAGTGTGAGGTGCAGGGTAT TCCACCACCAACAGTGACCTGGATGAAAGATGGCCACCCCTTGATCAAGGCAAAGGGAGTAGAAATACTGGATGAAGGTCACATCCTTCA GCTGAAGAACATTCATGTATCTGACACAGGCCGTTATGTGTGTGTTGCTGTGAATGTAGCAGGAATGACTGACAAAAAATATGACTTAAG TGTCCATGCTCCTCCAAGCATCATAGGAAACCACAGGTCACCTGAAAATATTAGTGTGGTAGAAAAGAACTCAGTATCTTTGACTTGTGA AGCTTCTGGAATTCCCCTGCCTTCCATAACCTGGTTCAAAGATGGGTGGCCTGTCAGCCTTAGCAATTCTGTGAGGATTCTTTCAGGAGG CAGGATGCTACGGCTGATGCAGACCACAATGGAAGATGCTGGCCAATATACTTGCGTTGTAAGGAATGCAGCTGGTGAAGAAAGAAAAAT CTTTGGGCTTTCAGTATTAGTACCACCTCATATTGTGGGTGAAAATACATTGGAAGATGTGAAGGTAAAAGAGAAACAGAGTGTTACGCT GACTTGTGAAGTGACAGGGAATCCAGTGCCAGAAATTACATGGCACAAAGATGGGCAGCCCCTCCAAGAAGATGAAGCCCATCACATTAT ATCTGGTGGCCGTTTTCTTCAAATTACCAATGTCCAGGTGCCACACACTGGAAGATATACATGTTTGGCTTCCAGTCCAGCTGGCCACAA GAGCAGGAGCTTCAGTCTTAATGTATTTGTATCTCCTACAATTGCTGGTGTAGGTAGTGATGGCAACCCTGAAGATGTCACTGTCATCCT TAACAGCCCTACATCTTTGGTCTGTGAAGCTTATTCATATCCTCCAGCTACCATCACCTGGTTTAAGGATGGCACTCCTTTAGAATCTAA CCGAAATATTCGTATTCTTCCAGGAGGCAGAACTCTGCAGATCCTCAATGCACAGGAGGACAATGCTGGAAGATACTCTTGTGTAGCCAC GAATGAGGCTGGAGAAATGATAAAGCACTATGAAGTGAAGGTGTACATTCCACCCATAATCAATAAAGGGGACCTTTGGGGGCCAGGTCT TTCCCCTAAAGAAGTGAAGATCAAAGTAAACAACACTCTGACCTTGGAATGTGAAGCGTATGCAATTCCTTCTGCCTCCCTCAGCTGGTA CAAGGATGGACAGCCCCTTAAATCCGATGATCATGTTAATATTGCTGCGAATGGACACACACTTCAAATAAAGGAGGCTCAAATATCAGA CACCGGACGATATACTTGTGTAGCATCTAACATTGCAGGTGAAGATGAGTTGGATTTTGATGTGAATATTCAAGTTCCTCCAAGTTTTCA GAAACTCTGGGAAATAGGAAACATGCTAGATACTGGCAGGAATGGTGAAGCCAAAGATGTGATCATCAACAATCCCATTTCTCTTTACTG TGAGACAAATGCTGCTCCCCCTCCTACACTGACATGGTACAAAGATGGCCACCCTCTGACCTCAAGTGATAAAGTATTGATTTTGCCAGG AGGGCGAGTGTTGCAGATTCCTCGGGCTAAAGTAGAAGATGCTGGGAGATACACATGTGTGGCTGTGAATGAGGCTGGAGAAGATTCCCT TCAATATGATGTCCGTGTACTCGTGCCGCCAATTATCAAGGGAGCAAATAGTGATCTCCCTGAAGAGGTCACCGTGCTGGTGAACAAGAG TGCACTGATAGAGTGTTTATCCAGTGGCAGCCCAGCACCAAGGAATTCCTGGCAGAAAGATGGACAGCCCTTGCTAGAAGATGACCATCA TAAATTTCTATCTAATGGACGAATTCTGCAGATTCTGAATACTCAAATAACAGATATCGGCAGGTATGTGTGTGTTGCTGAGAACACAGC TGGGAGTGCCAAAAAATATTTTAACCTCAATGTTCATGTTCCTCCAAGTGTCATTGGTCCTAAATCTGAAAATCTTACCGTCGTGGTGAA CAATTTCATCTCTTTGACCTGTGAGGTCTCTGGTTTTCCACCTCCTGACCTCAGCTGGCTCAAGAATGAACAGCCCATCAAACTGAACAC AAATACTCTCATTGTGCCTGGTGGTCGAACTCTACAGATTATTCGGGCCAAGGTATCAGATGGTGGTGAATACACTTGTATAGCTATCAA TCAAGCTGGCGAAAGCAAGAAAAAGTTTTCCCTGACTGTTTATGTGCCCCCAAGCATTAAAGACCATGACAGTGAATCTCTTTCTGTAGT TAATGTAAGAGAGGGAACTTCTGTGTCTTTGGAGTGTGAGTCGAACGCTGTGCCACCTCCAGTCATCACTTGGTATAAGAATGGGCGGAT GATAACAGAGTCTACTCATGTGGAGATTTTAGCTGATGGACAAATGCTACACATTAAGAAAGCTGAGGTATCTGACACAGGCCAGTATGT ATGTAGAGCTATAAATGTAGCAGGACGGGATGATAAAAATTTCCACCTCAATGTATATGTGCCACCCAGTATTGAAGGACCTGAAAGAGA AGTGATTGTGGAGACGATCAGCAATCCTGTGACATTAACATGTGATGCCACTGGGATCCCACCTCCCACGATAGCATGGTTAAAGAACCA CAAGCGCATAGAAAATTCTGACTCACTGGAAGTTCGTATTTTGTCTGGAGGTAGCAAACTCCAGATTGCCCGGTCTCAGCATTCAGATAG TGGAAACTATACATGTATTGCTTCAAATATGGAGGGAAAAGCCCAGAAATATTACTTTCTTTCAATTCAAGTTCCTCCAAGTGTTGCTGG TGCTGAAATTCCAAGTGATGTCAGTGTCCTTCTAGGAGAAAATGTTGAGCTGGTCTGCAATGCAAATGGCATTCCTACTCCACTTATTCA ATGGCTTAAAGATGGAAAGCCCATAGCTAGTGGTGAAACAGAAAGAATCCGAGTGAGTGCAAATGGCAGCACATTAAACATTTATGGAGC TCTTACATCTGACACGGGGAAATACACATGTGTTGCTACTAATCCCGCTGGAGAAGAAGACCGAATTTTTAACTTGAATGTCTATGTTAC ACCTACAATTAGGGGTAATAAAGATGAAGCAGAGAAACTAATGACTTTAGTGGATACTTCAATAAATATTGAATGCAGAGCCACAGGGAC GCCTCCACCACAGATAAACTGGCTGAAGAATGGACTTCCTCTGCCTCTCTCCTCCCATATCCGGTTACTGGCAGCAGGACAAGTTATCAG GATTGTGAGAGCTCAGGTGTCTGATGTCGCTGTGTATACTTGTGTGGCCTCCAACAGAGCTGGGGTGGATAATAAGCATTACAATCTTCA AGTGTTTGCACCACCAAATATGGACAATTCAATGGGGACAGAGGAAATCACAGTTCTCAAAGGTAGTTCCACCTCTATGGCATGCATTAC TGATGGAACCCCAGCTCCCAGTATGGCCTGGCTTAGAGATGGCCAGCCTCTGGGGCTTGATGCCCATCTGACAGTCAGCACCCATGGAAT GGTCCTGCAGCTCCTCAAAGCAGAGACTGAAGATTCGGGAAAGTACACCTGCATTGCCTCAAATGAAGCTGGAGAAGTCAGCAAGCACTT TATCCTCAAGGTCCTAGAACCACCTCACATTAATGGATCTGAAGAACATGAAGAGATATCAGTAATTGTTAATAACCCACTTGAACTTAC CTGCATTGCTTCTGGAATCCCAGCCCCTAAAATGACCTGGATGAAAGATGGCCGGCCCCTTCCACAGACGGATCAAGTGCAAACTCTAGG AGGAGGAGAGGTTCTTCGAATTTCTACTGCTCAGGTGGAGGATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAGGAGATGATGA TAAGGAATATCTAGTGAGAGTGCATGTACCTCCTAATATTGCTGGAACTGATGAGCCCCGGGATATCACTGTGTTACGGAACAGACAAGT GACATTGGAATGCAAGTCAGATGCAGTGCCCCCACCTGTAATTACTTGGCTCAGAAATGGAGAACGGTTACAGGCAACACCTCGAGTGCG AATCCTATCTGGAGGGAGATACTTGCAAATCAACAATGCTGACCTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAACATTGCAGG AAAGACTACAAGAGAATTTATTCTCACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCCCCAGAGCCTTGTAATTCTTTTAAATAAGTC AACTGTATTGGAATGCATCGCTGAAGGTGTGCCAACTCCAAGGATAACATGGAGAAAGGATGGAGCTGTTCTAGCTGGGAATCATGCAAG ATATTCCATCTTGGAAAATGGATTCCTTCATATTCAATCAGCACATGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAATGCTGC TGGAACAGATCGCAGGCGAATAGATTTACAGGTCCATGTTCCTCCATCTATTGCTCCGGGTCCTACCAACATGACTGTAATAGTAAATGT TCAAACTACTCTGGCTTGTGAGGCTACTGGGATACCAAAACCATCAATCAATTGGAGAAAAAATGGGCATCTTCTTAATGTGGATCAAAA TCAGAACTCATACAGGCTCCTTTCTTCAGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGTACTGTGAC AAACGGTGCTGGAGATGATAAAAGAACTGTGGATCTCACTGTCCAAGTTCCACCTTCCATAGCTGATGAGCCTACAGATTTCCTAGTAAC CAAACATGCCCCAGCAGTAATTACCTGCACTGCTTCGGGAGTTCCATTTCCCTCAATTCACTGGACCAAAAATGGTATAAGACTGCTTCC CAGGGGAGATGGCTATAGAATTCTGTCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTGTGTCGC TAGGAATGCGGCTGGCTCTGCACATCGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCATTCAGCCCCAACCAAGTGAACTACACGT CATTCTGAACAATCCTATTTTATTACCATGTGAAGCAACAGGGACACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAA CACTTCAGGCAGAAACCATGCAGTTCTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGTGTGT GGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGT TATTGCTGTGGACAAGCCCATCACGTTATCCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAAT TGTGGAATCTATCCGCCAGCGCGTCCTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGCAT GGCAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGATCAGAAGTACAGAAGGACACTACAC GGTCAATGAGAATTCACAAGCCATTCTTCCATGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTT AGCTAACTTGTTAGGAAAATACACTGCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTG TGTTGCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTTTTACTGAACTTCCTGGAGACGT GTCATTAAATAAAGGAGAACAGCTACGATTAAGCTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATAT TATTCCAGCCCACTTTGACAGTGTGAATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCAC CGCAGAGAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTTTATGTGAAAGAACCTCCAGTCTTCAAAGGTGATTATCCTTCTAACTG GATTGAACCACTTGGTGGGAATGCAATCCTGAATTGTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGA TATTGAAATTAGCCACAGAATCCGGCAACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATG TGTAGCTACCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCACTCTTGAGCCAGTGGAAAC TGTTATTAATGCTGGTGGCAAAATCATATTGAATTGTCAGGCAACTGGAGAGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTC TATTTCCTGGGATGACCGGGTTAACGTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATG TGTTGCTCGAAACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCCAGTGGTCTGCATGGAG AGCCTGCAGTGTCACCTGTGGAAAAGGCATCCAAAAGAGGAGTCGTCTGTGCAACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCA AGGTTCAGATTTGGAAATGCGAAACTGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCAC AAGGAGCTGTGGACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCATGTGAAGGGAATGC TGTGGAAATAATTATGTGCAACATTAGGCCTTGCCCAGTTCATGGAGCATGGAGCGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTG TGGGAAAGGTACTCAGACAAGAGCAAGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACAGAT GCAAGTTTGCAATGAAAGAAATTGTCCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTCATGTGGAGGAGG TGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTGCCCCAGTATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTG CAACAGTGACCCTTGCCCAACCCATGGTAACTGGAGTCCTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCG GCGGTACCGCACATGTGATAACCCTCCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGTGCAACACTGA CATGTGTCCTGTGGATGGAAGTTGGGGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCCTCCTGTGGAGGAGGTGAAAAGACTCGGAAGCG GCTGTGCGACCATCCTGTGCCAGTTAAAGGTGGCCGTCCCTGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCC AGGTGGGCCCCAGCGAGCCAGAGGAAGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACAATAACTGA TAGCCCTAACTCTGATACTAGAATAATACGTGCCAAAATTACCAATGTACCTCGTAGTCTTGGTTCAGCAATGAGAAAGATAGTTTCTAT TCTAAATCCCATTTATTGGACAACAGCAAAGGAAATAGGAGAAGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAAC TCAAGTGGAATTTGCAACTGGAGAAATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGATATCGT TGTGAGTGGCTATGTCCTACAGCTTCAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAGAGGACTACATTCAAACAGGTCCTGGGCA GCTGTACGCCTACTCAACCCGGCTGTTCACCATTGATGGCATCAGCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACA GGGAAGAATGCCTTTCTTGGTTGAAACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTAAAAT TCATGCTTCAATATCCAAAGGAGATCGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCAGTTGGACCTTTTTGTGCTGATGAGGA TGAATGTGCAGCAGGGAATCCCTGCTCCCATAGCTGCCACAATGCCATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGC TGCAGATGGAAGAACTTGTCAAGATATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATTGG ATCTTATCGCTGTGTGGTCCGTTGTGGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCAAGATATTAATGAATGTCAAGAATC CAGCCCCTGTCACCAGCGCTGTTTCAATGCCATAGGAAGTTTCCATTGTGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCAT GGATGTGAACGAGTGTAGACAAAATGTATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCC AAATGGAATGACCAAGGCAGAAAATGGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATCAGTGCAGATATAACCAGATATG TGAGAATACAAGAGGCAGCTATCGTTGTGTATGCCCAAGAGGTTATCGGTCTCAAGGAGTTGGAAGACCCTGCATGGACATTAATGAATG TGAACAAGTGCCTAAACCTTGTGCACATCAGTGCTCCAACACCCCCGGCAGCTTCAAGTGTATCTGTCCACCAGGACAACATTTATTAGG GGACGGGAAATCTTGCGCTGGATTGGAGAGGCTGCCAAATTATGGCACTCAATACAGTAGCTATAACCTTGCACGGTTCTCCCCTGTGAG AAACAACTATCAACCTCAACAGCATTACAGACAGTACTCACATCTCTACAGCTCCTACTCAGAGTATAGAAACAGCAGAACATCTCTCTC CAGGACTAGAAGGACTATTAGGAAAACTTGCCCTGAAGGCTCTGAGGCAAGCCATGACACATGTGTAGATATTGATGAATGTGAAAATAC AGATGCCTGCCAGCATGAGTGTAAGAATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACACACAATGGAAAGAC ATGCCAAGATATCGATGAATGTCTGGAGCAGAATGTGCACTGTGGACCCAATCGCATGTGCTTCAACATGAGAGGAAGCTACCAGTGCAT CGATACACCCTGTCCACCCAACTACCAACGGGATCCTGTTTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGAATGTGCCTT GAGCCCATATGCCTTGGAATACAAACTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGTTGCATACACACA GGATGGAGTGATGCATCCCAGGACAACTTTCCTCATGGTAGATGAGGAACAGACTGTTCCTTTTGCCTTGAGGGATGAAAACCTGAAAGG AGTGGTGTATACAACACGACCACTACGAGAAGCAGAGACCTACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGGGACCATTGA ATATCAGACCACATTCATAGTTTATATAGCTGTGTCCGCCTATCCATACTAAGGAACTCTCCAAAGCCTATTCCACATATTTAAACCGCA TTAATCATGGCAATCAAGCCCCCTTCCAGATTACTGTCTCTTGAACAGTTGCAATCTTGGCAGCTTGAAAATGGTGCTACACTCTGTTTT GTGTGCCTTCCTTGGTACTTCTGAGGTATTTTCATGATCCCACCATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCTTATTATTTT ATTTATTACACTGGAGCAGTTACTTCCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTGTAGTACCTA AGATCATTTTCCTGAAAGCCAAACCAAACAACGAAAAACAAGAACAACTAATTCAGAATCAAATAGAGTTTTTGAGCATTTGACTATTTT TAGAATCATAAAATTAGTTACTAAGTATTTTGATCAAAGCTTATAAAATAACTTACGGAGATTTTTGTAAGTATTGATACATTATAATAG GACTTGCCTATTTTCATTTTTAAGAAGAAAAACACCACTCATTTTATAAAATATAGTACAGCTACTATAAGGCTTGTTTGATCCCAAATG GTGCTTATCTTGATTGAACATTCAGAACAAGGATATTATTTTCAGTGATTTTGTGAGATCAGCTGAACCACTTATGATAATAATAATAAA AAAGACTGCTTTGCCCTCACGTCAGTTGTACATGGCATGGAACTTTAAAAATTTTAATATAAACTTTCATCCAGTTAGCTTCATAACTTT TACGTTCCAGAATTTTGTTTATTTTCCTGTCAATGAAAGCAATTTTTAAAGATACCAGTGGGACAGATTTGGTTTTTTAAAAATCTCATG TGTTCAAATTAACATAAATATTACACGTCAATACACTGTACATGGTGGTAATAGACTCTAAGCAATTGCCAAGATGTATTCTATTTTTAT GAAGTGTATATATATTACCTTAGTGTGCATTTTCTATATAATATCTTGATGGACTCTTTTATAAAATTATTTTATAAAAAACAATGTTAC >68685_68685_1_PRKAR2B-HMCN1_PRKAR2B_chr7_106710761_ENST00000265717_HMCN1_chr1_185815158_ENST00000271588_length(amino acids)=5660AA_BP=114 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEE EEAAPADAGAFNAPVINRFTRRASEIGPVTITTDPKKFQYELRELYVQGGGDCPEMSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHE VLQLIQQKQSQVVFVLTGDCDDRTHIGYKVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQASKVHLLSTDHLEQAVNTWRIPFDPSLK EVTVSLSGPSPMIEIRNPLGKLIKKGFGLHELLNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTV SRPVQGIPTYVLLNTSGISTPARIDLLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPPNEAFFLKVTGYDKDDYLFQRVSSVSFSS IVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFD VSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF LTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST LRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK IQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNV AGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDS GMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI ASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQAL YIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAN DNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI DERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQ PVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWY KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW LKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTL TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPP PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECE VQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVS LTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQ SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLW GPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVP PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVA ENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTC IAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDT GQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLN IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG QVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVS THGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQAT PRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN VDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGI RLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG INVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKD GRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF NNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSR QGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGG KPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTC SESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQ SDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEK TRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRK IVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQT GPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVGPFC ADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE CQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRY NQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARF SPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTH NGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLV -------------------------------------------------------------- >68685_68685_2_PRKAR2B-HMCN1_PRKAR2B_chr7_106710761_ENST00000265717_HMCN1_chr1_185815158_ENST00000367492_length(transcript)=17966nt_BP=602nt GCCGCGGCTGGAGCGGGAGGAGCAGGAGATGCTGCCAGCCCTCCCGGGGCCGCGCTCGCTCAGCCGCCGCCACCACACGGAGCAGACGCG CGCCGGGAGCCGCGGGCCGGGCCAGCCGGGCCGCCGGGGCCCAGTGCGCCGCGCTCGCAGCCGGTAGCGCGCCAGCGCCGTAGGCGCTCG CTCGGCAGCCGCGGGGCCCTAGGCCGTGCCGGGGAGGGGGCGAGGGCGGCGCCCAGGCGCCTGCCGCCCCGGAGGCAGGATGAGCATCGA GATCCCGGCGGGACTGACGGAGCTGCTGCAGGGCTTCACGGTGGAGGTGCTGAGGCACCAGCCCGCGGACCTGCTGGAGTTCGCGCTGCA GCACTTCACCCGCCTGCAGCAGGAGAACGAGCGCAAAGGCACCGCGCGCTTCGGCCATGAGGGCAGGACCTGGGGGGACCTGGGCGCCGC TGCCGGGGGCGGCACCCCCAGCAAGGGGGTCAACTTCGCCGAGGAGCCCATGCAGTCCGACTCCGAGGACGGGGAGGAGGAGGAGGCGGC GCCCGCGGACGCAGGGGCGTTCAATGCTCCAGTAATAAACCGATTCACAAGGCGTGCCTCAGAAATTGGCCCAGTGACAATTACCACAGA TCCCAAGAAATTTCAATATGAACTCAGAGAACTGTATGTTCAGGGTGGTGGTGATTGCCCAGAAATGAGTATTGGAGCTATAAAAATTGC CTTGGAAATTTCTCTTCCTGGTTCTTTCATCTATGTTTTCACTGATGCTCGGTCCAAAGATTACCGGCTCACCCATGAGGTGCTGCAACT TATCCAACAGAAACAGTCACAAGTCGTATTTGTTCTGACTGGAGATTGTGATGACAGGACCCATATTGGATATAAAGTCTATGAAGAAAT TGCCTCTACAAGTTCTGGTCAAGTGTTCCATCTGGACAAAAAACAAGTTAATGAGGTATTAAAATGGGTAGAAGAAGCAGTACAGGCCTC CAAAGTTCACCTTTTATCCACAGATCATTTGGAACAGGCTGTAAATACTTGGAGAATTCCTTTTGATCCCAGCCTGAAAGAGGTCACTGT GTCTTTGAGTGGGCCTTCTCCAATGATTGAAATTCGCAATCCTTTAGGGAAGCTGATAAAAAAGGGATTTGGCCTGCATGAGCTATTAAA TATCCATAACTCTGCCAAAGTAGTGAATGTGAAAGAGCCAGAGGCTGGAATGTGGACAGTGAAGACCTCAAGCAGTGGAAGGCACTCTGT TCGCATTACTGGCCTCAGTACTATTGATTTCCGAGCTGGCTTTTCTCGAAAGCCCACCCTGGACTTCAAAAAAACAGTCAGCAGACCAGT GCAAGGAATACCTACCTATGTACTGCTCAATACTTCTGGAATTTCCACTCCAGCTAGAATAGATCTTCTTGAACTTTTGAGTATCTCAGG AAGTTCTCTTAAGACTATTCCTGTTAAATATTACCCACATCGAAAACCTTATGGCATATGGAATATTTCTGACTTTGTACCACCAAATGA AGCTTTCTTTCTCAAAGTAACAGGCTATGATAAAGATGATTACCTCTTCCAGAGAGTATCAAGTGTTTCCTTTTCTAGTATTGTCCCAGA TGCTCCCAAAGTTACGATGCCTGAGAAAACCCCAGGATACTATCTGCAGCCGGGCCAAATTCCCTGCTCTGTTGACAGTCTTTTGCCCTT TACCTTGAGCTTTGTCAGAAATGGAGTTACACTTGGAGTAGACCAGTATTTGAAAGAATCTGCCAGTGTGAACTTAGATATTGCAAAGGT CACTTTGTCTGACGAAGGTTTCTATGAATGCATTGCTGTCAGCAGTGCAGGTACTGGACGGGCACAGACATTTTTTGACGTATCAGAGCC CCCTCCGGTCATCCAAGTGCCTAACAATGTTACAGTCACTCCTGGAGAGAGAGCAGTTTTAACATGTCTCATCATCAGTGCGGTGGATTA CAATCTAACCTGGCAGAGGAATGACAGAGATGTCAGACTGGCAGAGCCAGCGAGAATTAGGACCTTGGCTAATCTGTCATTGGAGCTAAA GAGTGTGAAATTCAACGATGCTGGAGAGTATCATTGTATGGTTTCTAGTGAAGGTGGATCATCAGCCGCTTCAGTTTTCCTCACAGTGCA AGAACCACCCAAAGTCACTGTGATGCCCAAGAATCAGTCTTTCACAGGAGGGTCTGAGGTCTCCATCATGTGTTCTGCAACAGGTTATCC CAAACCAAAGATTGCCTGGACCGTTAACGATATGTTTATCGTGGGTTCACACAGGTATAGGATGACCTCAGATGGTACCTTATTTATCAA AAATGCAGCTCCCAAAGATGCAGGGATCTATGGTTGCCTAGCAAGTAATTCAGCTGGAACAGATAAACAGAATTCTACTCTCAGATACAT TGAAGCCCCTAAGTTGATGGTAGTTCAGAGTGAGCTCTTGGTTGCCCTTGGGGATATAACCGTTATGGAATGCAAAACCTCTGGTATTCC TCCACCTCAAGTTAAATGGTTCAAAGGAGATCTTGAGTTGAGGCCCTCAACATTCCTCATTATTGACCCTCTCTTGGGACTTTTGAAGAT TCAAGAAACACAAGATCTGGATGCTGGCGATTATACCTGTGTAGCCATCAATGAGGCTGGAAGAGCAACTGGCAAGATAACTCTGGATGT TGGCTCACCTCCAGTTTTCATACAAGAACCTGCTGATGTGTCTATGGAAATTGGCTCAAATGTGACATTACCTTGTTATGTTCAGGGTTA TCCAGAACCAACAATCAAATGGCGAAGATTAGACAACATGCCAATTTTCTCAAGACCTTTTTCAGTTAGTTCCATCAGCCAACTAAGAAC AGGAGCTCTCTTTATTTTAAACTTATGGGCAAGTGATAAAGGAACCTATATTTGTGAAGCTGAAAACCAGTTTGGAAAGATCCAGTCAGA GACAACAGTAACAGTGACCGGACTTGTTGCTCCACTTATTGGAATCAGCCCTTCAGTGGCCAATGTTATTGAAGGACAGCAGCTTACTTT GCCCTGTACTCTGTTAGCTGGAAATCCCATTCCAGAACGTCGGTGGATTAAGAATTCAGCTATGTTGCTCCAAAATCCTTACATCACTGT GCGCAGTGATGGGAGCCTCCATATTGAAAGAGTTCAGCTTCAGGATGGTGGTGAATATACTTGTGTGGCCAGTAACGTTGCTGGGACCAA TAACAAAACTACCTCTGTGGTTGTGCATGTTCTGCCAACCATTCAGCATGGGCAGCAGATACTCAGTACAATTGAAGGCATTCCAGTAAC TTTACCATGCAAAGCAAGTGGAAATCCCAAACCGTCTGTCATCTGGTCCAAGAAAGGAGAGCTGATTTCAACCAGCAGTGCTAAGTTTTC AGCAGGAGCTGATGGTAGTCTGTATGTGGTATCACCTGGAGGAGAGGAGAGTGGGGAGTATGTCTGCACTGCCACCAATACAGCCGGCTA CGCCAAAAGGAAAGTGCAGCTAACAGTCTATGTAAGGCCCAGAGTGTTTGGAGATCAACGAGGACTGTCCCAGGATAAGCCTGTTGAGAT CTCCGTCCTTGCAGGGGAAGAGGTAACACTTCCATGTGAAGTGAAGAGCTTACCTCCACCCATAATTACTTGGGCCAAAGAAACCCAGCT CATCTCACCGTTCTCTCCAAGACACACATTCCTCCCTTCTGGTTCAATGAAGATCACTGAAACCCGCACTTCAGATAGTGGGATGTATCT TTGTGTTGCCACAAATATTGCTGGGAATGTGACTCAGGCTGTCAAATTAAATGTCCATGTTCCTCCAAAGATACAGCGTGGACCTAAACA TCTCAAAGTCCAAGTTGGTCAAAGAGTGGATATTCCATGTAATGCTCAAGGGACTCCTCTTCCTGTAATCACCTGGTCCAAAGGTGGAAG CACTATGCTGGTTGATGGAGAGCACCATGTTAGCAATCCAGACGGAACTTTAAGCATCGACCAAGCCACGCCCTCAGATGCTGGCATATA TACATGTGTTGCTACTAACATAGCAGGCACTGATGAAACAGAGATAACGCTACATGTCCAAGAACCACCCACAGTGGAAGATCTAGAACC TCCATATAACACTACTTTCCAAGAAAGAGTGGCCAATCAACGCATTGAATTTCCATGTCCTGCAAAAGGTACCCCTAAACCAACCATCAA ATGGTTACACAATGGTAGAGAGTTGACAGGCAGAGAGCCTGGCATTTCTATCTTGGAAGATGGCACATTGCTGGTTATTGCTTCTGTTAC ACCCTATGACAATGGGGAGTACATCTGTGTGGCAGTCAATGAAGCTGGAACCACAGAAAGAAAATATAACCTCAAAGTCCATGTTCCTCC AGTAATTAAAGATAAAGAACAAGTTACAAATGTGTCGGTGTTGTTAAATCAGCTGACCAATCTCTTCTGTGAAGTGGAAGGCACTCCATC TCCCATCATTATGTGGTATAAAGATAATGTCCAGGTGACTGAAAGCAGCACTATTCAGACTGTGAACAATGGGAAGATACTGAAGCTCTT CAGAGCCACTCCAGAGGATGCAGGAAGATATTCCTGCAAAGCAATTAATATTGCAGGCACTTCTCAGAAGTACTTTAACATTGATGTGCT AGTTCCACCCACCATAATAGGTACCAACTTCCCAAATGAAGTCTCAGTTGTCCTCAACCGTGACGTCGCCCTTGAATGCCAGGTCAAAGG CACTCCCTTTCCTGATATTCATTGGTTCAAAGATGGCAAGCCTTTATTTTTGGGCGATCCTAATGTTGAACTTCTAGACAGAGGACAAGT CTTACATTTAAAGAATGCACGGAGAAATGACAAGGGGCGCTACCAATGTACTGTGTCTAATGCAGCTGGCAAACAAGCCAAGGATATAAA ACTGACTATCTATATTCCACCTAGTATTAAAGGAGGAAATGTCACCACAGACATATCAGTATTGATCAACAGCCTTATTAAACTGGAATG TGAAACACGGGGACTTCCAATGCCTGCCATTACTTGGTATAAGGACGGGCAGCCAATCATGTCCAGCTCACAAGCACTTTATATTGATAA AGGACAATATCTTCATATTCCTCGAGCACAGGTCTCTGATTCAGCAACATATACGTGTCATGTAGCCAATGTTGCTGGAACTGCTGAAAA ATCATTCCATGTGGATGTCTATGTTCCTCCAATGATTGAAGGCAACTTGGCCACGCCTTTGAATAAGCAAGTAGTTATTGCTCATTCTCT GACACTGGAGTGCAAAGCTGCTGGAAACCCTTCTCCCATTCTCACCTGGTTGAAAGATGGTGTACCTGTGAAAGCTAATGACAATATCCG CATAGAAGCTGGTGGGAAGAAACTCGAAATCATGAGTGCCCAAGAAATTGATCGAGGACAGTACATATGCGTGGCTACCAGTGTGGCAGG AGAAAAGGAAATCAAATATGAAGTTGATGTCTTGGTGCCACCAGCTATAGAAGGAGGAGATGAAACATCTTACTTCATTGTGATGGTTAA TAACTTACTGGAGCTAGATTGTCATGTGACAGGCTCTCCCCCACCAACTATCATGTGGCTGAAGGATGGCCAGTTAATTGATGAAAGGGA TGGATTCAAGATTTTATTAAATGGACGCAAACTGGTTATTGCTCAGGCTCAAGTGTCAAACACAGGCCTTTATCGGTGCATGGCAGCAAA TACTGCTGGAGACCACAAGAAGGAATTTGAAGTGACTGTTCATGTTCCTCCAACAATCAAGTCCTCAGGCCTTTCTGAGAGAGTTGTGGT AAAATACAAGCCTGTCGCCTTGCAGTGCATAGCCAATGGGATTCCAAATCCTTCCATTACATGGTTAAAAGATGACCAGCCTGTGAACAC TGCCCAAGGAAACCTTAAAATACAGTCTTCTGGTCGAGTTCTACAAATTGCCAAAACCCTGTTGGAAGATGCTGGCAGATACACATGTGT GGCTACCAACGCAGCTGGAGAAACACAACAGCACATTCAACTGCATGTTCATGAACCACCTAGTCTGGAAGATGCTGGAAAAATGCTGAA TGAGACTGTGTTGGTGAGCAACCCTGTACAGCTGGAGTGTAAGGCAGCTGGAAATCCTGTGCCTGTTATTACATGGTACAAAGATAATCG TCTACTCTCAGGTTCCACCAGCATGACTTTCTTGAACAGAGGACAGATCATTGATATTGAAAGTGCCCAGATCTCAGATGCTGGCATATA TAAATGCGTGGCCATCAACTCAGCTGGAGCTACAGAGTTATTTTACAGTCTGCAAGTTCATGTGGCCCCATCAATTTCTGGCAGCAATAA CATGGTGGCAGTGGTGGTTAATAACCCGGTGAGGTTAGAATGTGAAGCCAGAGGTATTCCTGCCCCAAGTCTGACCTGGTTGAAAGATGG GAGTCCTGTTTCTAGTTTTTCTAATGGATTACAGGTTCTCTCTGGTGGTCGAATCCTAGCATTGACCAGTGCACAAATCAGCGACACAGG AAGGTACACCTGCGTGGCAGTGAATGCTGCTGGAGAAAAGCAAAGGGACATTGACCTCCGAGTATATGTTCCGCCAAATATTATGGGAGA AGAACAGAATGTCTCTGTCCTCATTAGCCAAGCTGTGGAATTACTATGTCAAAGTGATGCTATTCCCCCACCTACTCTTACTTGGTTAAA AGACGGCCACCCCTTGCTGAAGAAACCAGGCCTCAGTATATCTGAAAATAGAAGTGTGTTAAAGATTGAAGATGCTCAGGTTCAAGACAC TGGTCGTTACACTTGTGAAGCAACAAATGTTGCTGGAAAAACTGAAAAAAACTACAATGTCAACATTTGGGTCCCCCCAAATATTGGTGG TTCTGATGAACTTACTCAACTTACAGTCATTGAAGGGAATCTCATTAGTCTGTTGTGTGAATCAAGTGGTATTCCACCCCCAAATCTCAT CTGGAAGAAGAAAGGCTCTCCAGTGCTGACTGATTCCATGGGGCGAGTTAGAATTTTATCTGGGGGCAGGCAATTACAAATTTCAATTGC TGAAAAGTCTGATGCAGCACTCTATTCATGTGTGGCGTCGAATGTTGCTGGGACTGCAAAGAAAGAATACAATCTGCAAGTTTACATTAG ACCAACCATAACCAACAGTGGCAGCCACCCTACTGAAATTATTGTGACCCGAGGGAAGAGTATCTCCTTGGAGTGTGAGGTGCAGGGTAT TCCACCACCAACAGTGACCTGGATGAAAGATGGCCACCCCTTGATCAAGGCAAAGGGAGTAGAAATACTGGATGAAGGTCACATCCTTCA GCTGAAGAACATTCATGTATCTGACACAGGCCGTTATGTGTGTGTTGCTGTGAATGTAGCAGGAATGACTGACAAAAAATATGACTTAAG TGTCCATGCTCCTCCAAGCATCATAGGAAACCACAGGTCACCTGAAAATATTAGTGTGGTAGAAAAGAACTCAGTATCTTTGACTTGTGA AGCTTCTGGAATTCCCCTGCCTTCCATAACCTGGTTCAAAGATGGGTGGCCTGTCAGCCTTAGCAATTCTGTGAGGATTCTTTCAGGAGG CAGGATGCTACGGCTGATGCAGACCACAATGGAAGATGCTGGCCAATATACTTGCGTTGTAAGGAATGCAGCTGGTGAAGAAAGAAAAAT CTTTGGGCTTTCAGTATTAGTACCACCTCATATTGTGGGTGAAAATACATTGGAAGATGTGAAGGTAAAAGAGAAACAGAGTGTTACGCT GACTTGTGAAGTGACAGGGAATCCAGTGCCAGAAATTACATGGCACAAAGATGGGCAGCCCCTCCAAGAAGATGAAGCCCATCACATTAT ATCTGGTGGCCGTTTTCTTCAAATTACCAATGTCCAGGTGCCACACACTGGAAGATATACATGTTTGGCTTCCAGTCCAGCTGGCCACAA GAGCAGGAGCTTCAGTCTTAATGTATTTGTATCTCCTACAATTGCTGGTGTAGGTAGTGATGGCAACCCTGAAGATGTCACTGTCATCCT TAACAGCCCTACATCTTTGGTCTGTGAAGCTTATTCATATCCTCCAGCTACCATCACCTGGTTTAAGGATGGCACTCCTTTAGAATCTAA CCGAAATATTCGTATTCTTCCAGGAGGCAGAACTCTGCAGATCCTCAATGCACAGGAGGACAATGCTGGAAGATACTCTTGTGTAGCCAC GAATGAGGCTGGAGAAATGATAAAGCACTATGAAGTGAAGGTGTACATTCCACCCATAATCAATAAAGGGGACCTTTGGGGGCCAGGTCT TTCCCCTAAAGAAGTGAAGATCAAAGTAAACAACACTCTGACCTTGGAATGTGAAGCGTATGCAATTCCTTCTGCCTCCCTCAGCTGGTA CAAGGATGGACAGCCCCTTAAATCCGATGATCATGTTAATATTGCTGCGAATGGACACACACTTCAAATAAAGGAGGCTCAAATATCAGA CACCGGACGATATACTTGTGTAGCATCTAACATTGCAGGTGAAGATGAGTTGGATTTTGATGTGAATATTCAAGTTCCTCCAAGTTTTCA GAAACTCTGGGAAATAGGAAACATGCTAGATACTGGCAGGAATGGTGAAGCCAAAGATGTGATCATCAACAATCCCATTTCTCTTTACTG TGAGACAAATGCTGCTCCCCCTCCTACACTGACATGGTACAAAGATGGCCACCCTCTGACCTCAAGTGATAAAGTATTGATTTTGCCAGG AGGGCGAGTGTTGCAGATTCCTCGGGCTAAAGTAGAAGATGCTGGGAGATACACATGTGTGGCTGTGAATGAGGCTGGAGAAGATTCCCT TCAATATGATGTCCGTGTACTCGTGCCGCCAATTATCAAGGGAGCAAATAGTGATCTCCCTGAAGAGGTCACCGTGCTGGTGAACAAGAG TGCACTGATAGAGTGTTTATCCAGTGGCAGCCCAGCACCAAGGAATTCCTGGCAGAAAGATGGACAGCCCTTGCTAGAAGATGACCATCA TAAATTTCTATCTAATGGACGAATTCTGCAGATTCTGAATACTCAAATAACAGATATCGGCAGGTATGTGTGTGTTGCTGAGAACACAGC TGGGAGTGCCAAAAAATATTTTAACCTCAATGTTCATGTTCCTCCAAGTGTCATTGGTCCTAAATCTGAAAATCTTACCGTCGTGGTGAA CAATTTCATCTCTTTGACCTGTGAGGTCTCTGGTTTTCCACCTCCTGACCTCAGCTGGCTCAAGAATGAACAGCCCATCAAACTGAACAC AAATACTCTCATTGTGCCTGGTGGTCGAACTCTACAGATTATTCGGGCCAAGGTATCAGATGGTGGTGAATACACTTGTATAGCTATCAA TCAAGCTGGCGAAAGCAAGAAAAAGTTTTCCCTGACTGTTTATGTGCCCCCAAGCATTAAAGACCATGACAGTGAATCTCTTTCTGTAGT TAATGTAAGAGAGGGAACTTCTGTGTCTTTGGAGTGTGAGTCGAACGCTGTGCCACCTCCAGTCATCACTTGGTATAAGAATGGGCGGAT GATAACAGAGTCTACTCATGTGGAGATTTTAGCTGATGGACAAATGCTACACATTAAGAAAGCTGAGGTATCTGACACAGGCCAGTATGT ATGTAGAGCTATAAATGTAGCAGGACGGGATGATAAAAATTTCCACCTCAATGTATATGTGCCACCCAGTATTGAAGGACCTGAAAGAGA AGTGATTGTGGAGACGATCAGCAATCCTGTGACATTAACATGTGATGCCACTGGGATCCCACCTCCCACGATAGCATGGTTAAAGAACCA CAAGCGCATAGAAAATTCTGACTCACTGGAAGTTCGTATTTTGTCTGGAGGTAGCAAACTCCAGATTGCCCGGTCTCAGCATTCAGATAG TGGAAACTATACATGTATTGCTTCAAATATGGAGGGAAAAGCCCAGAAATATTACTTTCTTTCAATTCAAGTTCCTCCAAGTGTTGCTGG TGCTGAAATTCCAAGTGATGTCAGTGTCCTTCTAGGAGAAAATGTTGAGCTGGTCTGCAATGCAAATGGCATTCCTACTCCACTTATTCA ATGGCTTAAAGATGGAAAGCCCATAGCTAGTGGTGAAACAGAAAGAATCCGAGTGAGTGCAAATGGCAGCACATTAAACATTTATGGAGC TCTTACATCTGACACGGGGAAATACACATGTGTTGCTACTAATCCCGCTGGAGAAGAAGACCGAATTTTTAACTTGAATGTCTATGTTAC ACCTACAATTAGGGGTAATAAAGATGAAGCAGAGAAACTAATGACTTTAGTGGATACTTCAATAAATATTGAATGCAGAGCCACAGGGAC GCCTCCACCACAGATAAACTGGCTGAAGAATGGACTTCCTCTGCCTCTCTCCTCCCATATCCGGTTACTGGCAGCAGGACAAGTTATCAG GATTGTGAGAGCTCAGGTGTCTGATGTCGCTGTGTATACTTGTGTGGCCTCCAACAGAGCTGGGGTGGATAATAAGCATTACAATCTTCA AGTGTTTGCACCACCAAATATGGACAATTCAATGGGGACAGAGGAAATCACAGTTCTCAAAGGTAGTTCCACCTCTATGGCATGCATTAC TGATGGAACCCCAGCTCCCAGTATGGCCTGGCTTAGAGATGGCCAGCCTCTGGGGCTTGATGCCCATCTGACAGTCAGCACCCATGGAAT GGTCCTGCAGCTCCTCAAAGCAGAGACTGAAGATTCGGGAAAGTACACCTGCATTGCCTCAAATGAAGCTGGAGAAGTCAGCAAGCACTT TATCCTCAAGGTCCTAGAACCACCTCACATTAATGGATCTGAAGAACATGAAGAGATATCAGTAATTGTTAATAACCCACTTGAACTTAC CTGCATTGCTTCTGGAATCCCAGCCCCTAAAATGACCTGGATGAAAGATGGCCGGCCCCTTCCACAGACGGATCAAGTGCAAACTCTAGG AGGAGGAGAGGTTCTTCGAATTTCTACTGCTCAGGTGGAGGATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAGGAGATGATGA TAAGGAATATCTAGTGAGAGTGCATGTACCTCCTAATATTGCTGGAACTGATGAGCCCCGGGATATCACTGTGTTACGGAACAGACAAGT GACATTGGAATGCAAGTCAGATGCAGTGCCCCCACCTGTAATTACTTGGCTCAGAAATGGAGAACGGTTACAGGCAACACCTCGAGTGCG AATCCTATCTGGAGGGAGATACTTGCAAATCAACAATGCTGACCTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAACATTGCAGG AAAGACTACAAGAGAATTTATTCTCACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCCCCAGAGCCTTGTAATTCTTTTAAATAAGTC AACTGTATTGGAATGCATCGCTGAAGGTGTGCCAACTCCAAGGATAACATGGAGAAAGGATGGAGCTGTTCTAGCTGGGAATCATGCAAG ATATTCCATCTTGGAAAATGGATTCCTTCATATTCAATCAGCACATGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAATGCTGC TGGAACAGATCGCAGGCGAATAGATTTACAGGTCCATGTTCCTCCATCTATTGCTCCGGGTCCTACCAACATGACTGTAATAGTAAATGT TCAAACTACTCTGGCTTGTGAGGCTACTGGGATACCAAAACCATCAATCAATTGGAGAAAAAATGGGCATCTTCTTAATGTGGATCAAAA TCAGAACTCATACAGGCTCCTTTCTTCAGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGTACTGTGAC AAACGGTGCTGGAGATGATAAAAGAACTGTGGATCTCACTGTCCAAGTTCCACCTTCCATAGCTGATGAGCCTACAGATTTCCTAGTAAC CAAACATGCCCCAGCAGTAATTACCTGCACTGCTTCGGGAGTTCCATTTCCCTCAATTCACTGGACCAAAAATGGTATAAGACTGCTTCC CAGGGGAGATGGCTATAGAATTCTGTCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTGTGTCGC TAGGAATGCGGCTGGCTCTGCACATCGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCATTCAGCCCCAACCAAGTGAACTACACGT CATTCTGAACAATCCTATTTTATTACCATGTGAAGCAACAGGGACACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAA CACTTCAGGCAGAAACCATGCAGTTCTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGTGTGT GGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGT TATTGCTGTGGACAAGCCCATCACGTTATCCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAAT TGTGGAATCTATCCGCCAGCGCGTCCTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGCAT GGCAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGATCAGAAGTACAGAAGGACACTACAC GGTCAATGAGAATTCACAAGCCATTCTTCCATGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTT AGCTAACTTGTTAGGAAAATACACTGCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTG TGTTGCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTTTTACTGAACTTCCTGGAGACGT GTCATTAAATAAAGGAGAACAGCTACGATTAAGCTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATAT TATTCCAGCCCACTTTGACAGTGTGAATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCAC CGCAGAGAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTTTATGTGAAAGAACCTCCAGTCTTCAAAGGTGATTATCCTTCTAACTG GATTGAACCACTTGGTGGGAATGCAATCCTGAATTGTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGA TATTGAAATTAGCCACAGAATCCGGCAACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATG TGTAGCTACCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCACTCTTGAGCCAGTGGAAAC TGTTATTAATGCTGGTGGCAAAATCATATTGAATTGTCAGGCAACTGGAGAGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTC TATTTCCTGGGATGACCGGGTTAACGTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATG TGTTGCTCGAAACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCCAGTGGTCTGCATGGAG AGCCTGCAGTGTCACCTGTGGAAAAGGCATCCAAAAGAGGAGTCGTCTGTGCAACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCA AGGTTCAGATTTGGAAATGCGAAACTGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCAC AAGGAGCTGTGGACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCATGTGAAGGGAATGC TGTGGAAATAATTATGTGCAACATTAGGCCTTGCCCAGTTCATGGAGCATGGAGCGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTG TGGGAAAGGTACTCAGACAAGAGCAAGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACAGAT GCAAGTTTGCAATGAAAGAAATTGTCCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTCATGTGGAGGAGG TGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTGCCCCAGTATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTG CAACAGTGACCCTTGCCCAACCCATGGTAACTGGAGTCCTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCG GCGGTACCGCACATGTGATAACCCTCCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGTGCAACACTGA CATGTGTCCTGTGGATGGAAGTTGGGGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCCTCCTGTGGAGGAGGTGAAAAGACTCGGAAGCG GCTGTGCGACCATCCTGTGCCAGTTAAAGGTGGCCGTCCCTGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCC AGGTGGGCCCCAGCGAGCCAGAGGAAGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACAATAACTGA TAGCCCTAACTCTGATACTAGAATAATACGTGCCAAAATTACCAATGTACCTCGTAGTCTTGGTTCAGCAATGAGAAAGATAGTTTCTAT TCTAAATCCCATTTATTGGACAACAGCAAAGGAAATAGGAGAAGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAAC TCAAGTGGAATTTGCAACTGGAGAAATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGATATCGT TGTGAGTGGCTATGTCCTACAGCTTCAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAGAGGACTACATTCAAACAGGTCCTGGGCA GCTGTACGCCTACTCAACCCGGCTGTTCACCATTGATGGCATCAGCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACA GGGAAGAATGCCTTTCTTGGTTGAAACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTAAAAT TCATGCTTCAATATCCAAAGGAGATCGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCAGTTGGACCTTTTTGTGCTGATGAGGA TGAATGTGCAGCAGGGAATCCCTGCTCCCATAGCTGCCACAATGCCATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGC TGCAGATGGAAGAACTTGTCAAGATATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATTGG ATCTTATCGCTGTGTGGTCCGTTGTGGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCAAGATATTAATGAATGTCAAGAATC CAGCCCCTGTCACCAGCGCTGTTTCAATGCCATAGGAAGTTTCCATTGTGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCAT GGATGTGAACGAGTGTAGACAAAATGTATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCC AAATGGAATGACCAAGGCAGAAAATGGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATCAGTGCAGATATAACCAGATATG TGAGAATACAAGAGGCAGCTATCGTTGTGTATGCCCAAGAGGTTATCGGTCTCAAGGAGTTGGAAGACCCTGCATGGATATTGATGAATG TGAAAATACAGATGCCTGCCAGCATGAGTGTAAGAATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACACACAA TGGAAAGACATGCCAAGATATCGATGAATGTCTGGAGCAGAATGTGCACTGTGGACCCAATCGCATGTGCTTCAACATGAGAGGAAGCTA CCAGTGCATCGATACACCCTGTCCACCCAACTACCAACGGGATCCTGTTTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGA ATGTGCCTTGAGCCCATATGCCTTGGAATACAAACTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGTTGC ATACACACAGGATGGAGTGATGCATCCCAGGACAACTTTCCTCATGGTAGATGAGGAACAGACTGTTCCTTTTGCCTTGAGGGATGAAAA CCTGAAAGGAGTGGTGTATACAACACGACCACTACGAGAAGCAGAGACCTACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGG GACCATTGAATATCAGACCACATTCATAGTTTATATAGCTGTGTCCGCCTATCCATACTAAGGAACTCTCCAAAGCCTATTCCACATATT TAAACCGCATTAATCATGGCAATCAAGCCCCCTTCCAGATTACTGTCTCTTGAACAGTTGCAATCTTGGCAGCTTGAAAATGGTGCTACA CTCTGTTTTGTGTGCCTTCCTTGGTACTTCTGAGGTATTTTCATGATCCCACCATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCT TATTATTTTATTTATTACACTGGAGCAGTTACTTCCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTG TAGTACCTAAGATCATTTTCCTGAAAGCCAAACCAAACAACGAAAAACAAGAACAACTAATTCAGAATCAAATAGAGTTTTTGAGCATTT GACTATTTTTAGAATCATAAAATTAGTTACTAAGTATTTTGATCAAAGCTTATAAAATAACTTACGGAGATTTTTGTAAGTATTGATACA TTATAATAGGACTTGCCTATTTTCATTTTTAAGAAGAAAAACACCACTCATTTTATAAAATATAGTACAGCTACTATAAGGCTTGTTTGA TCCCAAATGGTGCTTATCTTGATTGAACATTCAGAACAAGGATATTATTTTCAGTGATTTTGTGAGATCAGCTGAACCACTTATGATAAT AATAATAAAAAAGACTGCTTTGCCCTCACGTCAGTTGTACATGGCATGGAACTTTAAAAATTTTAATATAAACTTTCATCCAGTTAGCTT CATAACTTTTACGTTCCAGAATTTTGTTTATTTTCCTGTCAATGAAAGCAATTTTTAAAGATACCAGTGGGACAGATTTGGTTTTTTAAA AATCTCATGTGTTCAAATTAACATAAATATTACACGTCAATACACTGTACATGGTGGTAATAGACTCTAAGCAATTGCCAAGATGTATTC TATTTTTATGAAGTGTATATATATTACCTTAGTGTGCATTTTCTATATAATATCTTGATGGACTCTTTTATAAAATTATTTTATAAAAAA >68685_68685_2_PRKAR2B-HMCN1_PRKAR2B_chr7_106710761_ENST00000265717_HMCN1_chr1_185815158_ENST00000367492_length(amino acids)=5543AA_BP=114 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEE EEAAPADAGAFNAPVINRFTRRASEIGPVTITTDPKKFQYELRELYVQGGGDCPEMSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHE VLQLIQQKQSQVVFVLTGDCDDRTHIGYKVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQASKVHLLSTDHLEQAVNTWRIPFDPSLK EVTVSLSGPSPMIEIRNPLGKLIKKGFGLHELLNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTV SRPVQGIPTYVLLNTSGISTPARIDLLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPPNEAFFLKVTGYDKDDYLFQRVSSVSFSS IVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFD VSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF LTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST LRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK IQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNV AGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDS GMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI ASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQAL YIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAN DNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI DERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQ PVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWY KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW LKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTL TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPP PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECE VQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVS LTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQ SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLW GPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVP PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVA ENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTC IAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDT GQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLN IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG QVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVS THGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQAT PRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN VDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGI RLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG INVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKD GRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF NNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSR QGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGG KPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTC SESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQ SDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEK TRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRK IVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQT GPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVGPFC ADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE CQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRY NQICENTRGSYRCVCPRGYRSQGVGRPCMDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNM RGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFAL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PRKAR2B-HMCN1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PRKAR2B-HMCN1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PRKAR2B-HMCN1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |