FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRKAR2B-RELN (FusionGDB2 ID:68686)

Fusion Gene Summary for PRKAR2B-RELN

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAR2B-RELN
Fusion gene ID: 68686
HgeneTgene
Gene symbol

PRKAR2B

RELN

Gene ID

5577

5649

Gene nameprotein kinase cAMP-dependent type II regulatory subunit betareelin
SynonymsPRKAR2|RII-BETAETL7|LIS2|PRO1598|RL
Cytomap

7q22.3

7q22.1

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type II-beta regulatory subunitH_RG363E19.2WUGSC:H_RG363E19.2cAMP-dependent protein kinase type II-beta regulatory chainprotein kinase, cAMP-dependent, regulatory subunit type II betaprotein kinase, cAMP-dependent, regulreelin
Modification date2020032920200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000393613, ENST00000265717, 
ENST00000343529, ENST00000424685, 
ENST00000428762, ENST00000473945, 
Fusion gene scores* DoF score2 X 1 X 2=411 X 11 X 6=726
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/726*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAR2B [Title/Abstract] AND RELN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRKAR2B(106710761)-RELN(103393661), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR2B

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across PRKAR2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RELN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01APRKAR2Bchr7

106710761

+RELNchr7

103393661

-


Top

Fusion Gene ORF analysis for PRKAR2B-RELN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000393613ENST00000343529PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
3UTR-3CDSENST00000393613ENST00000424685PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
3UTR-3CDSENST00000393613ENST00000428762PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
3UTR-intronENST00000393613ENST00000473945PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
5CDS-intronENST00000265717ENST00000473945PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
In-frameENST00000265717ENST00000343529PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
In-frameENST00000265717ENST00000424685PRKAR2Bchr7

106710761

+RELNchr7

103393661

-
In-frameENST00000265717ENST00000428762PRKAR2Bchr7

106710761

+RELNchr7

103393661

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265717PRKAR2Bchr7106710761+ENST00000343529RELNchr7103393661-11463602259104343391
ENST00000265717PRKAR2Bchr7106710761+ENST00000428762RELNchr7103393661-11469602259104403393
ENST00000265717PRKAR2Bchr7106710761+ENST00000424685RELNchr7103393661-11469602259104403393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265717ENST00000343529PRKAR2Bchr7106710761+RELNchr7103393661-0.0003713680.99962866
ENST00000265717ENST00000428762PRKAR2Bchr7106710761+RELNchr7103393661-0.0006391030.99936086
ENST00000265717ENST00000424685PRKAR2Bchr7106710761+RELNchr7103393661-0.0006421940.99935776

Top

Fusion Genomic Features for PRKAR2B-RELN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PRKAR2B-RELN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:106710761/chr7:103393661)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRELNchr7:106710761chr7:103393661ENST000003435293643431_34601813459.0Compositional biasNote=Arg-rich (basic)
TgeneRELNchr7:106710761chr7:103393661ENST000004287623653431_34601813461.0Compositional biasNote=Arg-rich (basic)
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641029_10601813459.0DomainEGF-like 2
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641408_14411813459.0DomainEGF-like 3
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641764_17951813459.0DomainEGF-like 4
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642128_21601813459.0DomainEGF-like 5
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642477_25081813459.0DomainEGF-like 6
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642852_28831813459.0DomainEGF-like 7
TgeneRELNchr7:106710761chr7:103393661ENST000003435293643227_32591813459.0DomainEGF-like 8
TgeneRELNchr7:106710761chr7:103393661ENST00000343529364670_7011813459.0DomainEGF-like 1
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651029_10601813461.0DomainEGF-like 2
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651408_14411813461.0DomainEGF-like 3
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651764_17951813461.0DomainEGF-like 4
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652128_21601813461.0DomainEGF-like 5
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652477_25081813461.0DomainEGF-like 6
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652852_28831813461.0DomainEGF-like 7
TgeneRELNchr7:106710761chr7:103393661ENST000004287623653227_32591813461.0DomainEGF-like 8
TgeneRELNchr7:106710761chr7:103393661ENST00000428762365670_7011813461.0DomainEGF-like 1
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641156_11671813459.0RepeatNote=BNR 4
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641322_13331813459.0RepeatNote=BNR 5
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641534_15451813459.0RepeatNote=BNR 6
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641685_16961813459.0RepeatNote=BNR 7
TgeneRELNchr7:106710761chr7:103393661ENST000003435293641883_18941813459.0RepeatNote=BNR 8
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642042_20531813459.0RepeatNote=BNR 9
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642249_22601813459.0RepeatNote=BNR 10
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642398_24091813459.0RepeatNote=BNR 11
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642597_26081813459.0RepeatNote=BNR 12
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642777_27881813459.0RepeatNote=BNR 13
TgeneRELNchr7:106710761chr7:103393661ENST000003435293642978_29891813459.0RepeatNote=BNR 14
TgeneRELNchr7:106710761chr7:103393661ENST000003435293643142_31541813459.0RepeatNote=BNR 15
TgeneRELNchr7:106710761chr7:103393661ENST000003435293643362_33731813459.0RepeatNote=BNR 16
TgeneRELNchr7:106710761chr7:103393661ENST00000343529364592_6031813459.0RepeatNote=BNR 1
TgeneRELNchr7:106710761chr7:103393661ENST00000343529364798_8091813459.0RepeatNote=BNR 2
TgeneRELNchr7:106710761chr7:103393661ENST00000343529364951_9621813459.0RepeatNote=BNR 3
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651156_11671813461.0RepeatNote=BNR 4
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651322_13331813461.0RepeatNote=BNR 5
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651534_15451813461.0RepeatNote=BNR 6
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651685_16961813461.0RepeatNote=BNR 7
TgeneRELNchr7:106710761chr7:103393661ENST000004287623651883_18941813461.0RepeatNote=BNR 8
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652042_20531813461.0RepeatNote=BNR 9
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652249_22601813461.0RepeatNote=BNR 10
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652398_24091813461.0RepeatNote=BNR 11
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652597_26081813461.0RepeatNote=BNR 12
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652777_27881813461.0RepeatNote=BNR 13
TgeneRELNchr7:106710761chr7:103393661ENST000004287623652978_29891813461.0RepeatNote=BNR 14
TgeneRELNchr7:106710761chr7:103393661ENST000004287623653142_31541813461.0RepeatNote=BNR 15
TgeneRELNchr7:106710761chr7:103393661ENST000004287623653362_33731813461.0RepeatNote=BNR 16
TgeneRELNchr7:106710761chr7:103393661ENST00000428762365592_6031813461.0RepeatNote=BNR 1
TgeneRELNchr7:106710761chr7:103393661ENST00000428762365798_8091813461.0RepeatNote=BNR 2
TgeneRELNchr7:106710761chr7:103393661ENST00000428762365951_9621813461.0RepeatNote=BNR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR2Bchr7:106710761chr7:103393661ENST00000265717+211154_275114419.0Nucleotide bindingNote=cAMP 1
HgenePRKAR2Bchr7:106710761chr7:103393661ENST00000265717+211276_418114419.0Nucleotide bindingNote=cAMP 2
HgenePRKAR2Bchr7:106710761chr7:103393661ENST00000265717+2112_153114419.0RegionNote=Dimerization and phosphorylation
TgeneRELNchr7:106710761chr7:103393661ENST0000034352936426_1901813459.0DomainReelin
TgeneRELNchr7:106710761chr7:103393661ENST0000042876236526_1901813461.0DomainReelin


Top

Fusion Gene Sequence for PRKAR2B-RELN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68686_68686_1_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000343529_length(transcript)=11463nt_BP=602nt
GCCGCGGCTGGAGCGGGAGGAGCAGGAGATGCTGCCAGCCCTCCCGGGGCCGCGCTCGCTCAGCCGCCGCCACCACACGGAGCAGACGCG
CGCCGGGAGCCGCGGGCCGGGCCAGCCGGGCCGCCGGGGCCCAGTGCGCCGCGCTCGCAGCCGGTAGCGCGCCAGCGCCGTAGGCGCTCG
CTCGGCAGCCGCGGGGCCCTAGGCCGTGCCGGGGAGGGGGCGAGGGCGGCGCCCAGGCGCCTGCCGCCCCGGAGGCAGGATGAGCATCGA
GATCCCGGCGGGACTGACGGAGCTGCTGCAGGGCTTCACGGTGGAGGTGCTGAGGCACCAGCCCGCGGACCTGCTGGAGTTCGCGCTGCA
GCACTTCACCCGCCTGCAGCAGGAGAACGAGCGCAAAGGCACCGCGCGCTTCGGCCATGAGGGCAGGACCTGGGGGGACCTGGGCGCCGC
TGCCGGGGGCGGCACCCCCAGCAAGGGGGTCAACTTCGCCGAGGAGCCCATGCAGTCCGACTCCGAGGACGGGGAGGAGGAGGAGGCGGC
GCCCGCGGACGCAGGGGCGTTCAATGCTCCAGTAATAAACCGATTCACAAGGCGTGCCTCAGCTCCAACAGATGTCACTGTGCACCCACA
TCTAGCTGAAATACATAGTGACAGCATTATCCTGAGAGATGACTTTGACTCCTACCACCAACTGCAATTAAATCCAAATATATGGGTTGA
ATGTAACAACTGTGAGACTGGAGAACAGTGTGGCGCGATTATGCATGGCAATGCCGTCACCTTCTGTGAACCATATGGCCCACGAGAACT
GATTACCACAGGCCTTAATACAACAACAGCTTCTGTCCTCCAATTTTCCATTGGGTCAGGTTCATGTCGCTTTAGTTATTCAGACCCCAG
CATCATCGTGTTATATGCCAAGAATAACTCTGCGGACTGGATTCAGCTAGAGAAAATTAGAGCCCCTTCCAATGTCAGCACAATCATCCA
TATCCTCTACCTTCCTGAGGACGCCAAAGGGGAGAATGTCCAATTTCAGTGGAAGCAGGAAAATCTTCGTGTAGGTGAAGTGTATGAAGC
CTGCTGGGCCTTAGATAACATCTTGATCATCAATTCAGCTCACAGACAAGTCGTTTTAGAAGATAGTCTCGACCCAGTGGACACAGGCAA
CTGGCTTTTCTTCCCAGGAGCTACAGTTAAGCATAGCTGTCAGTCAGATGGGAACTCCATTTATTTCCATGGAAATGAAGGCAGCGAGTT
CAATTTTGCCACCACCAGGGATGTAGATCTTTCCACAGAAGATATTCAAGAGCAATGGTCAGAAGAATTTGAGAGCCAGCCTACAGGATG
GGATGTCTTGGGAGCTGTCATTGGTACAGAATGTGGAACGATAGAATCAGGCTTATCAATGGTCTTCCTCAAAGATGGAGAGAGGAAATT
ATGCACTCCATCCATGGACACTACCGGTTATGGGAACCTGAGGTTTTACTTTGTGATGGGAGGAATTTGTGACCCTGGAAATTCTCATGA
AAATGACATAATCCTGTATGCAAAAATTGAAGGAAGAAAAGAGCATATAACACTGGATACCCTTTCCTATTCCTCATATAAGGTTCCGTC
TTTGGTTTCTGTGGTCATCAATCCTGAACTTCAGACTCCTGCTACCAAATTTTGTCTCAGGCAAAAGAACCATCAAGGACATAATAGGAA
TGTCTGGGCTGTAGACTTTTTCCATGTCTTGCCTGTTCTCCCTTCTACAATGTCTCACATGATACAGTTTTCCATCAATCTGGGATGTGG
AACGCATCAGCCTGGTAACAGTGTCAGCTTGGAATTTTCTACCAACCATGGGCGCTCCTGGTCCCTCCTTCACACTGAATGCTTACCTGA
GATCTGTGCTGGACCCCACCTCCCCCACAGCACTGTCTACTCCTCTGAAAACTACAGTGGGTGGAACCGAATAACAATTCCCCTTCCTAA
CGCAGCACTAACCCGGAACACCAGGATTCGCTGGAGACAAACAGGACCAATCCTTGGAAACATGTGGGCAATTGATAATGTTTATATTGG
CCCGTCATGTCTCAAATTCTGTTCTGGCAGAGGACAGTGCACTAGACATGGTTGCAAGTGTGACCCTGGATTTTCTGGCCCAGCTTGTGA
GATGGCATCCCAGACATTCCCAATGTTTATTTCTGAAAGCTTTGGCAGTTCCAGGCTCTCCTCTTACCATAACTTTTACTCTATCCGTGG
TGCTGAAGTCAGCTTTGGTTGTGGTGTCTTGGCCAGTGGTAAGGCCCTGGTTTTCAACAAAGATGGGCGGCGTCAGCTAATTACATCTTT
CCTTGACAGCTCACAATCCAGGTTTCTCCAGTTCACACTGAGACTGGGGAGCAAATCTGTTCTGAGCACGTGCAGAGCCCCTGATCAGCC
TGGTGAAGGAGTTTTGTTGCATTATTCTTATGATAATGGGATAACTTGGAAACTCCTGGAGCATTATTCATATCTCAGCTATCATGAGCC
CAGAATAATCTCCGTAGAACTACCAGGTGATGCAAAGCAGTTTGGAATTCAGTTCAGATGGTGGCAACCGTATCATTCTTCCCAGAGAGA
AGATGTATGGGCTATTGATGAGATTATCATGACATCTGTGCTTTTCAACAGCATTAGTCTTGACTTTACCAATCTTGTGGAGGTCACTCA
GTCTCTGGGATTCTACCTTGGAAATGTTCAGCCATACTGTGGCCACGACTGGACCCTTTGTTTTACAGGAGATTCTAAACTTGCCTCAAG
TATGCGCTATGTGGAAACACAATCAATGCAGATAGGAGCATCCTATATGATTCAGTTCAGTTTGGTGATGGGATGTGGCCAGAAATACAC
CCCACACATGGACAACCAGGTGAAGCTGGAGTACTCAACCAACCACGGCCTTACCTGGCACCTCGTCCAAGAAGAATGCCTTCCAAGTAT
GCCAAGTTGTCAGGAATTTACATCAGCAAGTATTTACCATGCCAGTGAGTTTACACAGTGGAGGAGAGTCATAGTGCTTCTTCCCCAGAA
AACTTGGTCCAGTGCTACCCGTTTCCGCTGGAGCCAGAGCTATTACACAGCTCAAGACGAGTGGGCTTTGGACAGCATTTACATTGGGCA
GCAGTGCCCCAACATGTGCAGTGGGCATGGCTCATGCGATCATGGCATATGCAGGTGTGACCAGGGGTACCAAGGCACTGAATGCCACCC
AGAAGCTGCCCTTCCGTCCACAATTATGTCAGATTTTGAGAACCAGAATGGCTGGGAGTCTGACTGGCAAGAAGTTATTGGGGGAGAAAT
TGTAAAACCAGAACAAGGGTGTGGTGTCATCTCTTCTGGATCATCTCTGTACTTCAGCAAGGCTGGGAAAAGACAGCTGGTGAGTTGGGA
CCTGGATACTTCTTGGGTGGACTTTGTCCAGTTCTACATCCAGATAGGCGGAGAGAGTGCTTCATGCAACAAGCCTGACAGCAGAGAGGA
GGGCGTCCTCCTTCAGTACAGCAACAATGGGGGCATCCAGTGGCACCTGCTAGCAGAGATGTACTTTTCAGACTTCAGCAAACCCAGATT
TGTCTATCTGGAGCTTCCAGCTGCTGCCAAGACCCCTTGCACCAGGTTCCGCTGGTGGCAGCCCGTGTTCTCAGGGGAGGACTATGACCA
GTGGGCAGTCGATGACATCATCATTCTGTCCGAGAAGCAGAAGCAGATCATCCCAGTTATCAATCCAACTTTACCTCAGAACTTTTATGA
GAAGCCAGCTTTTGATTACCCTATGAATCAGATGAGTGTGTGGTTGATGTTGGCTAATGAAGGAATGGTTAAAAATGAAACCTTCTGTGC
TGCCACACCATCAGCAATGATATTTGGAAAATCAGATGGAGATCGATTTGCAGTAACTCGAGATTTGACCCTGAAACCTGGATATGTGCT
ACAGTTCAAGCTAAACATAGGTTGTGCCAATCAATTCAGCAGTACTGCTCCAGTTCTTCTTCAGTACTCTCATGATGCTGGTATGTCCTG
GTTTCTGGTGAAAGAAGGCTGTTACCCGGCTTCTGCAGGCAAAGGATGCGAAGGAAACTCCAGAGAACTAAGTGAGCCCACCATGTATCA
CACAGGGGACTTTGAAGAATGGACAAGAATCACCATTGTTATTCCAAGGTCTCTTGCATCCAGCAAGACCAGATTCCGATGGATCCAGGA
GAGCAGCTCACAGAAAAACGTGCCTCCATTTGGTTTAGATGGAGTGTACATATCCGAGCCTTGTCCCAGTTACTGCAGTGGCCATGGGGA
CTGCATTTCAGGAGTGTGTTTCTGTGACCTGGGATATACTGCTGCACAAGGAACCTGTGTGTCAAATGTCCCCAATCACAATGAGATGTT
CGATAGGTTTGAGGGGAAGCTCAGCCCTCTGTGGTACAAGATAACAGGTGCCCAGGTTGGAACTGGCTGTGGAACACTTAACGATGGCAA
ATCTCTCTACTTCAATGGCCCTGGGAAAAGGGAAGCCCGGACGGTCCCTCTGGACACCAGGAATATCAGACTTGTTCAATTTTATATACA
AATTGGAAGCAAAACTTCAGGCATTACCTGCATCAAACCAAGAACTAGAAATGAAGGGCTTATTGTTCAGTATTCAAATGACAATGGGAT
ACTCTGGCATTTGCTTCGAGAGTTGGACTTCATGTCCTTCCTGGAACCACAGATCATTTCCATTGACCTGCCACAGGACGCGAAGACACC
TGCAACGGCATTTCGATGGTGGCAACCGCAACATGGGAAGCATTCAGCCCAGTGGGCTTTGGATGATGTTCTTATAGGAATGAATGACAG
CTCTCAAACTGGATTTCAAGACAAATTTGATGGCTCTATAGATTTGCAAGCCAACTGGTATCGAATCCAAGGAGGTCAAGTTGATATTGA
CTGTCTCTCTATGGATACTGCTCTGATATTCACTGAAAACATAGGAAAACCTCGTTATGCTGAGACCTGGGATTTTCATGTGTCAGCATC
TACCTTTTTGCAGTTTGAAATGAGCATGGGCTGTAGCAAGCCCTTCAGCAACTCCCACAGTGTACAGCTCCAGTATTCTCTGAACAATGG
CAAGGACTGGCATCTTGTCACCGAAGAGTGTGTTCCTCCAACCATTGGCTGTCTGCATTACACGGAAAGTTCAATTTACACCTCGGAAAG
ATTCCAGAATTGGAAGCGGATCACTGTCTACCTTCCACTCTCCACCATTTCTCCCAGGACCCGGTTCAGATGGATTCAGGCCAACTACAC
TGTGGGGGCTGATTCCTGGGCGATTGATAATGTTGTACTGGCCTCAGGGTGCCCTTGGATGTGCTCAGGACGAGGGATTTGTGATGCTGG
ACGCTGTGTGTGTGACCGGGGCTTTGGTGGACCCTATTGTGTTCCTGTTGTTCCTCTGCCCTCGATTCTTAAAGACGATTTCAATGGGAA
TTTACATCCTGACCTTTGGCCTGAAGTGTATGGTGCAGAGAGGGGGAATCTGAATGGTGAAACCATCAAATCTGGAACATCTCTAATTTT
TAAAGGGGAAGGACTAAGGATGCTTATTTCAAGAGATCTAGATTGTACAAATACAATGTATGTCCAGTTTTCACTTAGATTTATAGCAAA
AAGTACCCCAGAGAGATCTCACTCTATTCTGTTACAATTCTCCATCAGTGGAGGAATCACTTGGCACCTGATGGATGAATTTTACTTTCC
TCAAACAACGAATATACTTTTCATCAATGTTCCCTTGCCATACACTGCCCAAACCAATGCTACAAGATTCAGACTCTGGCAACCTTATAA
TAACGGTAAGAAAGAAGAAATCTGGATTGTTGATGACTTCATTATCGATGGAAATAATGTAAACAACCCTGTGATGCTCTTGGATACATT
TGATTTTGGGCCCAGAGAAGACAATTGGTTTTTCTATCCTGGTGGTAACATCGGTCTTTATTGTCCATATTCTTCAAAGGGGGCACCTGA
AGAAGATTCAGCTATGGTGTTTGTTTCAAATGAAGTTGGTGAGCATTCCATTACCACCCGTGACCTAAATGTGAATGAGAACACCATCAT
ACAATTTGAGATCAACGTTGGCTGTTCGACTGATAGCTCATCCGCGGATCCAGTGAGACTGGAATTTTCAAGGGACTTCGGGGCGACCTG
GCACCTTCTGCTGCCCCTCTGCTACCACAGCAGCAGCCACGTCAGCTCTTTATGCTCCACCGAGCACCACCCCAGCAGCACCTACTACGC
AGGAACCATGCAGGGCTGGAGGAGGGAGGTCGTGCACTTTGGGAAGCTGCACCTTTGTGGATCTGTCCGTTTCAGATGGTACCAGGGATT
TTACCCTGCCGGCTCTCAGCCAGTGACATGGGCCATTGATAATGTCTACATCGGTCCCCAGTGTGAGGAGATGTGTAATGGACAGGGGAG
CTGTATCAATGGAACCAAATGTATATGTGACCCTGGCTACTCAGGTCCAACCTGTAAAATAAGCACCAAAAATCCTGATTTTCTCAAAGA
TGATTTCGAAGGTCAGCTAGAATCTGATAGATTCTTATTAATGAGTGGTGGGAAACCATCTCGAAAGTGTGGAATCCTTTCTAGTGGAAA
CAACCTCTTTTTCAATGAAGATGGCTTGCGCATGTTGATGACACGAGACCTGGATTTATCACATGCTAGATTTGTGCAGTTCTTCATGAG
ACTGGGATGTGGTAAAGGCGTTCCTGACCCCAGGAGTCAACCCGTGCTCCTACAGTATTCTCTCAACGGTGGCCTCTCGTGGAGTCTTCT
TCAGGAGTTCCTTTTCAGCAATTCCAGCAATGTGGGCAGGTACATTGCCCTGGAGATACCCTTGAAAGCCCGTTCTGGTTCTACTCGCCT
TCGCTGGTGGCAACCGTCTGAGAATGGGCACTTCTACAGCCCCTGGGTTATCGATCAGATTCTTATTGGAGGAAATATTTCTGGTAATAC
GGTCTTGGAAGATGATTTCACAACCCTTGATAGTAGGAAATGGCTGCTTCACCCAGGAGGCACCAAGATGCCCGTGTGTGGCTCTACTGG
TGATGCCCTGGTCTTCATTGAAAAGGCCAGCACCCGTTACGTGGTCAGCACAGACGTTGCCGTGAATGAGGATTCCTTCCTACAGATAGA
CTTCGCTGCCTCCTGCTCAGTCACAGACTCTTGTTATGCGATTGAATTGGAATACTCAGTAGATCTTGGATTGTCATGGCACCCATTGGT
AAGGGACTGTCTGCCTACCAATGTGGAATGCAGTCGCTATCATCTGCAACGGATCCTGGTGTCAGACACTTTCAACAAGTGGACTAGAAT
CACTCTGCCTCTCCCTCCTTATACCAGGTCCCAAGCCACTCGTTTCCGTTGGCATCAACCAGCTCCTTTTGACAAGCAGCAGACATGGGC
AATAGATAATGTCTATATCGGGGATGGCTGCATAGACATGTGCAGTGGCCATGGGAGATGCATCCAGGGAAACTGCGTCTGTGATGAACA
GTGGGGTGGCCTGTACTGTGATGACCCCGAGACCTCTCTTCCAACCCAACTCAAAGACAACTTCAATCGAGCTCCATCCAGTCAGAACTG
GCTGACTGTGAACGGAGGGAAATTGAGTACAGTGTGTGGAGCCGTGGCGTCGGGAATGGCTCTCCATTTCAGTGGGGGTTGTAGTCGATT
ATTAGTCACTGTGGATCTAAACCTCACTAATGCTGAGTTCATCCAATTTTACTTCATGTATGGGTGCCTGATTACACCAAACAACCGTAA
CCAAGGTGTTCTCTTGGAATATTCTGTCAATGGAGGCATTACCTGGAACCTGCTCATGGAGATTTTCTATGACCAGTACAGTAAGCCCGG
ATTTGTGAATATCCTTCTCCCTCCTGATGCTAAAGAGATTGCCACTCGCTTCCGCTGGTGGCAGCCAAGACATGACGGCCTGGATCAGAA
CGACTGGGCCATTGACAATGTCCTCATCTCAGGCTCTGCTGACCAAAGGACCGTTATGCTGGACACCTTCAGCAGCGCCCCAGTACCCCA
GCATGAGCGCTCCCCTGCAGATGCCGGCCCTGTCGGGAGGATCGCCTTTGACATGTTTATGGAAGACAAAACTTCAGTGAATGAGCACTG
GCTATTCCATGATGATTGTACAGTAGAAAGATTCTGTGACTCCCCTGATGGTGTGATGCTCTGTGGCAGTCATGATGGACGGGAGGTGTA
TGCAGTGACCCATGACCTGACTCCCACTGAAGGCTGGATTATGCAATTCAAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTCACTCGCAAACA
AAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATGAAGAAT
CAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAATATCTG
TGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGACTTATTT
GCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAATAAGAA
ACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACATTCTTG
GTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTATTCTCT
TCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCAGAAAAT
TAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAGCGTTGT
TTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTCCCATTT
CCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGATTTGTA
AAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTACAACACC
AGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAGCCCATG

>68686_68686_1_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000343529_length(amino acids)=3391AA_BP=113
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEE
EEAAPADAGAFNAPVINRFTRRASAPTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYG
PRELITTGLNTTTASVLQFSIGSGSCRFSYSDPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGE
VYEACWALDNILIINSAHRQVVLEDSLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGNEGSEFNFATTRDVDLSTEDIQEQWSEEFESQ
PTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNSHENDIILYAKIEGRKEHITLDTLSYSSY
KVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTE
CLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSG
PACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA
PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMTSVLFNSISLDFTNLV
EVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQEEC
LPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDSIYIGQQCPNMCSGHGSCDHGICRCDQGYQGT
ECHPEAALPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCNKPD
SREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQIIPVINPTLPQ
NFYEKPAFDYPMNQMSVWLMLANEGMVKNETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDA
GMSWFLVKEGCYPASAGKGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCS
GHGDCISGVCFCDLGYTAAQGTCVSNVPNHNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQ
FYIQIGSKTSGITCIKPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG
MNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYS
LNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVLASGCPWMCSGRGI
CDAGRCVCDRGFGGPYCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLR
FIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGNNVNNPVML
LDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFSRDF
GATWHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCN
GQGSCINGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQ
FFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNI
SGNTVLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSW
HPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGRCIQGNCV
CDEQWGGLYCDDPETSLPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITP
NNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSA
PVPQHERSPADAGPVGRIAFDMFMEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------
>68686_68686_2_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000424685_length(transcript)=11469nt_BP=602nt
GCCGCGGCTGGAGCGGGAGGAGCAGGAGATGCTGCCAGCCCTCCCGGGGCCGCGCTCGCTCAGCCGCCGCCACCACACGGAGCAGACGCG
CGCCGGGAGCCGCGGGCCGGGCCAGCCGGGCCGCCGGGGCCCAGTGCGCCGCGCTCGCAGCCGGTAGCGCGCCAGCGCCGTAGGCGCTCG
CTCGGCAGCCGCGGGGCCCTAGGCCGTGCCGGGGAGGGGGCGAGGGCGGCGCCCAGGCGCCTGCCGCCCCGGAGGCAGGATGAGCATCGA
GATCCCGGCGGGACTGACGGAGCTGCTGCAGGGCTTCACGGTGGAGGTGCTGAGGCACCAGCCCGCGGACCTGCTGGAGTTCGCGCTGCA
GCACTTCACCCGCCTGCAGCAGGAGAACGAGCGCAAAGGCACCGCGCGCTTCGGCCATGAGGGCAGGACCTGGGGGGACCTGGGCGCCGC
TGCCGGGGGCGGCACCCCCAGCAAGGGGGTCAACTTCGCCGAGGAGCCCATGCAGTCCGACTCCGAGGACGGGGAGGAGGAGGAGGCGGC
GCCCGCGGACGCAGGGGCGTTCAATGCTCCAGTAATAAACCGATTCACAAGGCGTGCCTCAGCTCCAACAGATGTCACTGTGCACCCACA
TCTAGCTGAAATACATAGTGACAGCATTATCCTGAGAGATGACTTTGACTCCTACCACCAACTGCAATTAAATCCAAATATATGGGTTGA
ATGTAACAACTGTGAGACTGGAGAACAGTGTGGCGCGATTATGCATGGCAATGCCGTCACCTTCTGTGAACCATATGGCCCACGAGAACT
GATTACCACAGGCCTTAATACAACAACAGCTTCTGTCCTCCAATTTTCCATTGGGTCAGGTTCATGTCGCTTTAGTTATTCAGACCCCAG
CATCATCGTGTTATATGCCAAGAATAACTCTGCGGACTGGATTCAGCTAGAGAAAATTAGAGCCCCTTCCAATGTCAGCACAATCATCCA
TATCCTCTACCTTCCTGAGGACGCCAAAGGGGAGAATGTCCAATTTCAGTGGAAGCAGGAAAATCTTCGTGTAGGTGAAGTGTATGAAGC
CTGCTGGGCCTTAGATAACATCTTGATCATCAATTCAGCTCACAGACAAGTCGTTTTAGAAGATAGTCTCGACCCAGTGGACACAGGCAA
CTGGCTTTTCTTCCCAGGAGCTACAGTTAAGCATAGCTGTCAGTCAGATGGGAACTCCATTTATTTCCATGGAAATGAAGGCAGCGAGTT
CAATTTTGCCACCACCAGGGATGTAGATCTTTCCACAGAAGATATTCAAGAGCAATGGTCAGAAGAATTTGAGAGCCAGCCTACAGGATG
GGATGTCTTGGGAGCTGTCATTGGTACAGAATGTGGAACGATAGAATCAGGCTTATCAATGGTCTTCCTCAAAGATGGAGAGAGGAAATT
ATGCACTCCATCCATGGACACTACCGGTTATGGGAACCTGAGGTTTTACTTTGTGATGGGAGGAATTTGTGACCCTGGAAATTCTCATGA
AAATGACATAATCCTGTATGCAAAAATTGAAGGAAGAAAAGAGCATATAACACTGGATACCCTTTCCTATTCCTCATATAAGGTTCCGTC
TTTGGTTTCTGTGGTCATCAATCCTGAACTTCAGACTCCTGCTACCAAATTTTGTCTCAGGCAAAAGAACCATCAAGGACATAATAGGAA
TGTCTGGGCTGTAGACTTTTTCCATGTCTTGCCTGTTCTCCCTTCTACAATGTCTCACATGATACAGTTTTCCATCAATCTGGGATGTGG
AACGCATCAGCCTGGTAACAGTGTCAGCTTGGAATTTTCTACCAACCATGGGCGCTCCTGGTCCCTCCTTCACACTGAATGCTTACCTGA
GATCTGTGCTGGACCCCACCTCCCCCACAGCACTGTCTACTCCTCTGAAAACTACAGTGGGTGGAACCGAATAACAATTCCCCTTCCTAA
CGCAGCACTAACCCGGAACACCAGGATTCGCTGGAGACAAACAGGACCAATCCTTGGAAACATGTGGGCAATTGATAATGTTTATATTGG
CCCGTCATGTCTCAAATTCTGTTCTGGCAGAGGACAGTGCACTAGACATGGTTGCAAGTGTGACCCTGGATTTTCTGGCCCAGCTTGTGA
GATGGCATCCCAGACATTCCCAATGTTTATTTCTGAAAGCTTTGGCAGTTCCAGGCTCTCCTCTTACCATAACTTTTACTCTATCCGTGG
TGCTGAAGTCAGCTTTGGTTGTGGTGTCTTGGCCAGTGGTAAGGCCCTGGTTTTCAACAAAGATGGGCGGCGTCAGCTAATTACATCTTT
CCTTGACAGCTCACAATCCAGGTTTCTCCAGTTCACACTGAGACTGGGGAGCAAATCTGTTCTGAGCACGTGCAGAGCCCCTGATCAGCC
TGGTGAAGGAGTTTTGTTGCATTATTCTTATGATAATGGGATAACTTGGAAACTCCTGGAGCATTATTCATATCTCAGCTATCATGAGCC
CAGAATAATCTCCGTAGAACTACCAGGTGATGCAAAGCAGTTTGGAATTCAGTTCAGATGGTGGCAACCGTATCATTCTTCCCAGAGAGA
AGATGTATGGGCTATTGATGAGATTATCATGACATCTGTGCTTTTCAACAGCATTAGTCTTGACTTTACCAATCTTGTGGAGGTCACTCA
GTCTCTGGGATTCTACCTTGGAAATGTTCAGCCATACTGTGGCCACGACTGGACCCTTTGTTTTACAGGAGATTCTAAACTTGCCTCAAG
TATGCGCTATGTGGAAACACAATCAATGCAGATAGGAGCATCCTATATGATTCAGTTCAGTTTGGTGATGGGATGTGGCCAGAAATACAC
CCCACACATGGACAACCAGGTGAAGCTGGAGTACTCAACCAACCACGGCCTTACCTGGCACCTCGTCCAAGAAGAATGCCTTCCAAGTAT
GCCAAGTTGTCAGGAATTTACATCAGCAAGTATTTACCATGCCAGTGAGTTTACACAGTGGAGGAGAGTCATAGTGCTTCTTCCCCAGAA
AACTTGGTCCAGTGCTACCCGTTTCCGCTGGAGCCAGAGCTATTACACAGCTCAAGACGAGTGGGCTTTGGACAGCATTTACATTGGGCA
GCAGTGCCCCAACATGTGCAGTGGGCATGGCTCATGCGATCATGGCATATGCAGGTGTGACCAGGGGTACCAAGGCACTGAATGCCACCC
AGAAGCTGCCCTTCCGTCCACAATTATGTCAGATTTTGAGAACCAGAATGGCTGGGAGTCTGACTGGCAAGAAGTTATTGGGGGAGAAAT
TGTAAAACCAGAACAAGGGTGTGGTGTCATCTCTTCTGGATCATCTCTGTACTTCAGCAAGGCTGGGAAAAGACAGCTGGTGAGTTGGGA
CCTGGATACTTCTTGGGTGGACTTTGTCCAGTTCTACATCCAGATAGGCGGAGAGAGTGCTTCATGCAACAAGCCTGACAGCAGAGAGGA
GGGCGTCCTCCTTCAGTACAGCAACAATGGGGGCATCCAGTGGCACCTGCTAGCAGAGATGTACTTTTCAGACTTCAGCAAACCCAGATT
TGTCTATCTGGAGCTTCCAGCTGCTGCCAAGACCCCTTGCACCAGGTTCCGCTGGTGGCAGCCCGTGTTCTCAGGGGAGGACTATGACCA
GTGGGCAGTCGATGACATCATCATTCTGTCCGAGAAGCAGAAGCAGATCATCCCAGTTATCAATCCAACTTTACCTCAGAACTTTTATGA
GAAGCCAGCTTTTGATTACCCTATGAATCAGATGAGTGTGTGGTTGATGTTGGCTAATGAAGGAATGGTTAAAAATGAAACCTTCTGTGC
TGCCACACCATCAGCAATGATATTTGGAAAATCAGATGGAGATCGATTTGCAGTAACTCGAGATTTGACCCTGAAACCTGGATATGTGCT
ACAGTTCAAGCTAAACATAGGTTGTGCCAATCAATTCAGCAGTACTGCTCCAGTTCTTCTTCAGTACTCTCATGATGCTGGTATGTCCTG
GTTTCTGGTGAAAGAAGGCTGTTACCCGGCTTCTGCAGGCAAAGGATGCGAAGGAAACTCCAGAGAACTAAGTGAGCCCACCATGTATCA
CACAGGGGACTTTGAAGAATGGACAAGAATCACCATTGTTATTCCAAGGTCTCTTGCATCCAGCAAGACCAGATTCCGATGGATCCAGGA
GAGCAGCTCACAGAAAAACGTGCCTCCATTTGGTTTAGATGGAGTGTACATATCCGAGCCTTGTCCCAGTTACTGCAGTGGCCATGGGGA
CTGCATTTCAGGAGTGTGTTTCTGTGACCTGGGATATACTGCTGCACAAGGAACCTGTGTGTCAAATGTCCCCAATCACAATGAGATGTT
CGATAGGTTTGAGGGGAAGCTCAGCCCTCTGTGGTACAAGATAACAGGTGCCCAGGTTGGAACTGGCTGTGGAACACTTAACGATGGCAA
ATCTCTCTACTTCAATGGCCCTGGGAAAAGGGAAGCCCGGACGGTCCCTCTGGACACCAGGAATATCAGACTTGTTCAATTTTATATACA
AATTGGAAGCAAAACTTCAGGCATTACCTGCATCAAACCAAGAACTAGAAATGAAGGGCTTATTGTTCAGTATTCAAATGACAATGGGAT
ACTCTGGCATTTGCTTCGAGAGTTGGACTTCATGTCCTTCCTGGAACCACAGATCATTTCCATTGACCTGCCACAGGACGCGAAGACACC
TGCAACGGCATTTCGATGGTGGCAACCGCAACATGGGAAGCATTCAGCCCAGTGGGCTTTGGATGATGTTCTTATAGGAATGAATGACAG
CTCTCAAACTGGATTTCAAGACAAATTTGATGGCTCTATAGATTTGCAAGCCAACTGGTATCGAATCCAAGGAGGTCAAGTTGATATTGA
CTGTCTCTCTATGGATACTGCTCTGATATTCACTGAAAACATAGGAAAACCTCGTTATGCTGAGACCTGGGATTTTCATGTGTCAGCATC
TACCTTTTTGCAGTTTGAAATGAGCATGGGCTGTAGCAAGCCCTTCAGCAACTCCCACAGTGTACAGCTCCAGTATTCTCTGAACAATGG
CAAGGACTGGCATCTTGTCACCGAAGAGTGTGTTCCTCCAACCATTGGCTGTCTGCATTACACGGAAAGTTCAATTTACACCTCGGAAAG
ATTCCAGAATTGGAAGCGGATCACTGTCTACCTTCCACTCTCCACCATTTCTCCCAGGACCCGGTTCAGATGGATTCAGGCCAACTACAC
TGTGGGGGCTGATTCCTGGGCGATTGATAATGTTGTACTGGCCTCAGGGTGCCCTTGGATGTGCTCAGGACGAGGGATTTGTGATGCTGG
ACGCTGTGTGTGTGACCGGGGCTTTGGTGGACCCTATTGTGTTCCTGTTGTTCCTCTGCCCTCGATTCTTAAAGACGATTTCAATGGGAA
TTTACATCCTGACCTTTGGCCTGAAGTGTATGGTGCAGAGAGGGGGAATCTGAATGGTGAAACCATCAAATCTGGAACATCTCTAATTTT
TAAAGGGGAAGGACTAAGGATGCTTATTTCAAGAGATCTAGATTGTACAAATACAATGTATGTCCAGTTTTCACTTAGATTTATAGCAAA
AAGTACCCCAGAGAGATCTCACTCTATTCTGTTACAATTCTCCATCAGTGGAGGAATCACTTGGCACCTGATGGATGAATTTTACTTTCC
TCAAACAACGAATATACTTTTCATCAATGTTCCCTTGCCATACACTGCCCAAACCAATGCTACAAGATTCAGACTCTGGCAACCTTATAA
TAACGGTAAGAAAGAAGAAATCTGGATTGTTGATGACTTCATTATCGATGGAAATAATGTAAACAACCCTGTGATGCTCTTGGATACATT
TGATTTTGGGCCCAGAGAAGACAATTGGTTTTTCTATCCTGGTGGTAACATCGGTCTTTATTGTCCATATTCTTCAAAGGGGGCACCTGA
AGAAGATTCAGCTATGGTGTTTGTTTCAAATGAAGTTGGTGAGCATTCCATTACCACCCGTGACCTAAATGTGAATGAGAACACCATCAT
ACAATTTGAGATCAACGTTGGCTGTTCGACTGATAGCTCATCCGCGGATCCAGTGAGACTGGAATTTTCAAGGGACTTCGGGGCGACCTG
GCACCTTCTGCTGCCCCTCTGCTACCACAGCAGCAGCCACGTCAGCTCTTTATGCTCCACCGAGCACCACCCCAGCAGCACCTACTACGC
AGGAACCATGCAGGGCTGGAGGAGGGAGGTCGTGCACTTTGGGAAGCTGCACCTTTGTGGATCTGTCCGTTTCAGATGGTACCAGGGATT
TTACCCTGCCGGCTCTCAGCCAGTGACATGGGCCATTGATAATGTCTACATCGGTCCCCAGTGTGAGGAGATGTGTAATGGACAGGGGAG
CTGTATCAATGGAACCAAATGTATATGTGACCCTGGCTACTCAGGTCCAACCTGTAAAATAAGCACCAAAAATCCTGATTTTCTCAAAGA
TGATTTCGAAGGTCAGCTAGAATCTGATAGATTCTTATTAATGAGTGGTGGGAAACCATCTCGAAAGTGTGGAATCCTTTCTAGTGGAAA
CAACCTCTTTTTCAATGAAGATGGCTTGCGCATGTTGATGACACGAGACCTGGATTTATCACATGCTAGATTTGTGCAGTTCTTCATGAG
ACTGGGATGTGGTAAAGGCGTTCCTGACCCCAGGAGTCAACCCGTGCTCCTACAGTATTCTCTCAACGGTGGCCTCTCGTGGAGTCTTCT
TCAGGAGTTCCTTTTCAGCAATTCCAGCAATGTGGGCAGGTACATTGCCCTGGAGATACCCTTGAAAGCCCGTTCTGGTTCTACTCGCCT
TCGCTGGTGGCAACCGTCTGAGAATGGGCACTTCTACAGCCCCTGGGTTATCGATCAGATTCTTATTGGAGGAAATATTTCTGGTAATAC
GGTCTTGGAAGATGATTTCACAACCCTTGATAGTAGGAAATGGCTGCTTCACCCAGGAGGCACCAAGATGCCCGTGTGTGGCTCTACTGG
TGATGCCCTGGTCTTCATTGAAAAGGCCAGCACCCGTTACGTGGTCAGCACAGACGTTGCCGTGAATGAGGATTCCTTCCTACAGATAGA
CTTCGCTGCCTCCTGCTCAGTCACAGACTCTTGTTATGCGATTGAATTGGAATACTCAGTAGATCTTGGATTGTCATGGCACCCATTGGT
AAGGGACTGTCTGCCTACCAATGTGGAATGCAGTCGCTATCATCTGCAACGGATCCTGGTGTCAGACACTTTCAACAAGTGGACTAGAAT
CACTCTGCCTCTCCCTCCTTATACCAGGTCCCAAGCCACTCGTTTCCGTTGGCATCAACCAGCTCCTTTTGACAAGCAGCAGACATGGGC
AATAGATAATGTCTATATCGGGGATGGCTGCATAGACATGTGCAGTGGCCATGGGAGATGCATCCAGGGAAACTGCGTCTGTGATGAACA
GTGGGGTGGCCTGTACTGTGATGACCCCGAGACCTCTCTTCCAACCCAACTCAAAGACAACTTCAATCGAGCTCCATCCAGTCAGAACTG
GCTGACTGTGAACGGAGGGAAATTGAGTACAGTGTGTGGAGCCGTGGCGTCGGGAATGGCTCTCCATTTCAGTGGGGGTTGTAGTCGATT
ATTAGTCACTGTGGATCTAAACCTCACTAATGCTGAGTTCATCCAATTTTACTTCATGTATGGGTGCCTGATTACACCAAACAACCGTAA
CCAAGGTGTTCTCTTGGAATATTCTGTCAATGGAGGCATTACCTGGAACCTGCTCATGGAGATTTTCTATGACCAGTACAGTAAGCCCGG
ATTTGTGAATATCCTTCTCCCTCCTGATGCTAAAGAGATTGCCACTCGCTTCCGCTGGTGGCAGCCAAGACATGACGGCCTGGATCAGAA
CGACTGGGCCATTGACAATGTCCTCATCTCAGGCTCTGCTGACCAAAGGACCGTTATGCTGGACACCTTCAGCAGCGCCCCAGTACCCCA
GCATGAGCGCTCCCCTGCAGATGCCGGCCCTGTCGGGAGGATCGCCTTTGACATGTTTATGGAAGACAAAACTTCAGTGAATGAGCACTG
GCTATTCCATGATGATTGTACAGTAGAAAGATTCTGTGACTCCCCTGATGGTGTGATGCTCTGTGGCAGTCATGATGGACGGGAGGTGTA
TGCAGTGACCCATGACCTGACTCCCACTGAAGGCTGGATTATGCAATTCAAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTATTTAGCACTCG
CAAACAAAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATG
AAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAA
TATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGAC
TTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAA
TAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACA
TTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTA
TTCTCTTCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCA
GAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAG
CGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTC
CCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGA
TTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTAC
AACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAG

>68686_68686_2_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000424685_length(amino acids)=3393AA_BP=113
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEE
EEAAPADAGAFNAPVINRFTRRASAPTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYG
PRELITTGLNTTTASVLQFSIGSGSCRFSYSDPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGE
VYEACWALDNILIINSAHRQVVLEDSLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGNEGSEFNFATTRDVDLSTEDIQEQWSEEFESQ
PTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNSHENDIILYAKIEGRKEHITLDTLSYSSY
KVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTE
CLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSG
PACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA
PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMTSVLFNSISLDFTNLV
EVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQEEC
LPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDSIYIGQQCPNMCSGHGSCDHGICRCDQGYQGT
ECHPEAALPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCNKPD
SREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQIIPVINPTLPQ
NFYEKPAFDYPMNQMSVWLMLANEGMVKNETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDA
GMSWFLVKEGCYPASAGKGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCS
GHGDCISGVCFCDLGYTAAQGTCVSNVPNHNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQ
FYIQIGSKTSGITCIKPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG
MNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYS
LNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVLASGCPWMCSGRGI
CDAGRCVCDRGFGGPYCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLR
FIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGNNVNNPVML
LDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFSRDF
GATWHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCN
GQGSCINGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQ
FFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNI
SGNTVLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSW
HPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGRCIQGNCV
CDEQWGGLYCDDPETSLPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITP
NNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSA
PVPQHERSPADAGPVGRIAFDMFMEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------
>68686_68686_3_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000428762_length(transcript)=11469nt_BP=602nt
GCCGCGGCTGGAGCGGGAGGAGCAGGAGATGCTGCCAGCCCTCCCGGGGCCGCGCTCGCTCAGCCGCCGCCACCACACGGAGCAGACGCG
CGCCGGGAGCCGCGGGCCGGGCCAGCCGGGCCGCCGGGGCCCAGTGCGCCGCGCTCGCAGCCGGTAGCGCGCCAGCGCCGTAGGCGCTCG
CTCGGCAGCCGCGGGGCCCTAGGCCGTGCCGGGGAGGGGGCGAGGGCGGCGCCCAGGCGCCTGCCGCCCCGGAGGCAGGATGAGCATCGA
GATCCCGGCGGGACTGACGGAGCTGCTGCAGGGCTTCACGGTGGAGGTGCTGAGGCACCAGCCCGCGGACCTGCTGGAGTTCGCGCTGCA
GCACTTCACCCGCCTGCAGCAGGAGAACGAGCGCAAAGGCACCGCGCGCTTCGGCCATGAGGGCAGGACCTGGGGGGACCTGGGCGCCGC
TGCCGGGGGCGGCACCCCCAGCAAGGGGGTCAACTTCGCCGAGGAGCCCATGCAGTCCGACTCCGAGGACGGGGAGGAGGAGGAGGCGGC
GCCCGCGGACGCAGGGGCGTTCAATGCTCCAGTAATAAACCGATTCACAAGGCGTGCCTCAGCTCCAACAGATGTCACTGTGCACCCACA
TCTAGCTGAAATACATAGTGACAGCATTATCCTGAGAGATGACTTTGACTCCTACCACCAACTGCAATTAAATCCAAATATATGGGTTGA
ATGTAACAACTGTGAGACTGGAGAACAGTGTGGCGCGATTATGCATGGCAATGCCGTCACCTTCTGTGAACCATATGGCCCACGAGAACT
GATTACCACAGGCCTTAATACAACAACAGCTTCTGTCCTCCAATTTTCCATTGGGTCAGGTTCATGTCGCTTTAGTTATTCAGACCCCAG
CATCATCGTGTTATATGCCAAGAATAACTCTGCGGACTGGATTCAGCTAGAGAAAATTAGAGCCCCTTCCAATGTCAGCACAATCATCCA
TATCCTCTACCTTCCTGAGGACGCCAAAGGGGAGAATGTCCAATTTCAGTGGAAGCAGGAAAATCTTCGTGTAGGTGAAGTGTATGAAGC
CTGCTGGGCCTTAGATAACATCTTGATCATCAATTCAGCTCACAGACAAGTCGTTTTAGAAGATAGTCTCGACCCAGTGGACACAGGCAA
CTGGCTTTTCTTCCCAGGAGCTACAGTTAAGCATAGCTGTCAGTCAGATGGGAACTCCATTTATTTCCATGGAAATGAAGGCAGCGAGTT
CAATTTTGCCACCACCAGGGATGTAGATCTTTCCACAGAAGATATTCAAGAGCAATGGTCAGAAGAATTTGAGAGCCAGCCTACAGGATG
GGATGTCTTGGGAGCTGTCATTGGTACAGAATGTGGAACGATAGAATCAGGCTTATCAATGGTCTTCCTCAAAGATGGAGAGAGGAAATT
ATGCACTCCATCCATGGACACTACCGGTTATGGGAACCTGAGGTTTTACTTTGTGATGGGAGGAATTTGTGACCCTGGAAATTCTCATGA
AAATGACATAATCCTGTATGCAAAAATTGAAGGAAGAAAAGAGCATATAACACTGGATACCCTTTCCTATTCCTCATATAAGGTTCCGTC
TTTGGTTTCTGTGGTCATCAATCCTGAACTTCAGACTCCTGCTACCAAATTTTGTCTCAGGCAAAAGAACCATCAAGGACATAATAGGAA
TGTCTGGGCTGTAGACTTTTTCCATGTCTTGCCTGTTCTCCCTTCTACAATGTCTCACATGATACAGTTTTCCATCAATCTGGGATGTGG
AACGCATCAGCCTGGTAACAGTGTCAGCTTGGAATTTTCTACCAACCATGGGCGCTCCTGGTCCCTCCTTCACACTGAATGCTTACCTGA
GATCTGTGCTGGACCCCACCTCCCCCACAGCACTGTCTACTCCTCTGAAAACTACAGTGGGTGGAACCGAATAACAATTCCCCTTCCTAA
CGCAGCACTAACCCGGAACACCAGGATTCGCTGGAGACAAACAGGACCAATCCTTGGAAACATGTGGGCAATTGATAATGTTTATATTGG
CCCGTCATGTCTCAAATTCTGTTCTGGCAGAGGACAGTGCACTAGACATGGTTGCAAGTGTGACCCTGGATTTTCTGGCCCAGCTTGTGA
GATGGCATCCCAGACATTCCCAATGTTTATTTCTGAAAGCTTTGGCAGTTCCAGGCTCTCCTCTTACCATAACTTTTACTCTATCCGTGG
TGCTGAAGTCAGCTTTGGTTGTGGTGTCTTGGCCAGTGGTAAGGCCCTGGTTTTCAACAAAGATGGGCGGCGTCAGCTAATTACATCTTT
CCTTGACAGCTCACAATCCAGGTTTCTCCAGTTCACACTGAGACTGGGGAGCAAATCTGTTCTGAGCACGTGCAGAGCCCCTGATCAGCC
TGGTGAAGGAGTTTTGTTGCATTATTCTTATGATAATGGGATAACTTGGAAACTCCTGGAGCATTATTCATATCTCAGCTATCATGAGCC
CAGAATAATCTCCGTAGAACTACCAGGTGATGCAAAGCAGTTTGGAATTCAGTTCAGATGGTGGCAACCGTATCATTCTTCCCAGAGAGA
AGATGTATGGGCTATTGATGAGATTATCATGACATCTGTGCTTTTCAACAGCATTAGTCTTGACTTTACCAATCTTGTGGAGGTCACTCA
GTCTCTGGGATTCTACCTTGGAAATGTTCAGCCATACTGTGGCCACGACTGGACCCTTTGTTTTACAGGAGATTCTAAACTTGCCTCAAG
TATGCGCTATGTGGAAACACAATCAATGCAGATAGGAGCATCCTATATGATTCAGTTCAGTTTGGTGATGGGATGTGGCCAGAAATACAC
CCCACACATGGACAACCAGGTGAAGCTGGAGTACTCAACCAACCACGGCCTTACCTGGCACCTCGTCCAAGAAGAATGCCTTCCAAGTAT
GCCAAGTTGTCAGGAATTTACATCAGCAAGTATTTACCATGCCAGTGAGTTTACACAGTGGAGGAGAGTCATAGTGCTTCTTCCCCAGAA
AACTTGGTCCAGTGCTACCCGTTTCCGCTGGAGCCAGAGCTATTACACAGCTCAAGACGAGTGGGCTTTGGACAGCATTTACATTGGGCA
GCAGTGCCCCAACATGTGCAGTGGGCATGGCTCATGCGATCATGGCATATGCAGGTGTGACCAGGGGTACCAAGGCACTGAATGCCACCC
AGAAGCTGCCCTTCCGTCCACAATTATGTCAGATTTTGAGAACCAGAATGGCTGGGAGTCTGACTGGCAAGAAGTTATTGGGGGAGAAAT
TGTAAAACCAGAACAAGGGTGTGGTGTCATCTCTTCTGGATCATCTCTGTACTTCAGCAAGGCTGGGAAAAGACAGCTGGTGAGTTGGGA
CCTGGATACTTCTTGGGTGGACTTTGTCCAGTTCTACATCCAGATAGGCGGAGAGAGTGCTTCATGCAACAAGCCTGACAGCAGAGAGGA
GGGCGTCCTCCTTCAGTACAGCAACAATGGGGGCATCCAGTGGCACCTGCTAGCAGAGATGTACTTTTCAGACTTCAGCAAACCCAGATT
TGTCTATCTGGAGCTTCCAGCTGCTGCCAAGACCCCTTGCACCAGGTTCCGCTGGTGGCAGCCCGTGTTCTCAGGGGAGGACTATGACCA
GTGGGCAGTCGATGACATCATCATTCTGTCCGAGAAGCAGAAGCAGATCATCCCAGTTATCAATCCAACTTTACCTCAGAACTTTTATGA
GAAGCCAGCTTTTGATTACCCTATGAATCAGATGAGTGTGTGGTTGATGTTGGCTAATGAAGGAATGGTTAAAAATGAAACCTTCTGTGC
TGCCACACCATCAGCAATGATATTTGGAAAATCAGATGGAGATCGATTTGCAGTAACTCGAGATTTGACCCTGAAACCTGGATATGTGCT
ACAGTTCAAGCTAAACATAGGTTGTGCCAATCAATTCAGCAGTACTGCTCCAGTTCTTCTTCAGTACTCTCATGATGCTGGTATGTCCTG
GTTTCTGGTGAAAGAAGGCTGTTACCCGGCTTCTGCAGGCAAAGGATGCGAAGGAAACTCCAGAGAACTAAGTGAGCCCACCATGTATCA
CACAGGGGACTTTGAAGAATGGACAAGAATCACCATTGTTATTCCAAGGTCTCTTGCATCCAGCAAGACCAGATTCCGATGGATCCAGGA
GAGCAGCTCACAGAAAAACGTGCCTCCATTTGGTTTAGATGGAGTGTACATATCCGAGCCTTGTCCCAGTTACTGCAGTGGCCATGGGGA
CTGCATTTCAGGAGTGTGTTTCTGTGACCTGGGATATACTGCTGCACAAGGAACCTGTGTGTCAAATGTCCCCAATCACAATGAGATGTT
CGATAGGTTTGAGGGGAAGCTCAGCCCTCTGTGGTACAAGATAACAGGTGCCCAGGTTGGAACTGGCTGTGGAACACTTAACGATGGCAA
ATCTCTCTACTTCAATGGCCCTGGGAAAAGGGAAGCCCGGACGGTCCCTCTGGACACCAGGAATATCAGACTTGTTCAATTTTATATACA
AATTGGAAGCAAAACTTCAGGCATTACCTGCATCAAACCAAGAACTAGAAATGAAGGGCTTATTGTTCAGTATTCAAATGACAATGGGAT
ACTCTGGCATTTGCTTCGAGAGTTGGACTTCATGTCCTTCCTGGAACCACAGATCATTTCCATTGACCTGCCACAGGACGCGAAGACACC
TGCAACGGCATTTCGATGGTGGCAACCGCAACATGGGAAGCATTCAGCCCAGTGGGCTTTGGATGATGTTCTTATAGGAATGAATGACAG
CTCTCAAACTGGATTTCAAGACAAATTTGATGGCTCTATAGATTTGCAAGCCAACTGGTATCGAATCCAAGGAGGTCAAGTTGATATTGA
CTGTCTCTCTATGGATACTGCTCTGATATTCACTGAAAACATAGGAAAACCTCGTTATGCTGAGACCTGGGATTTTCATGTGTCAGCATC
TACCTTTTTGCAGTTTGAAATGAGCATGGGCTGTAGCAAGCCCTTCAGCAACTCCCACAGTGTACAGCTCCAGTATTCTCTGAACAATGG
CAAGGACTGGCATCTTGTCACCGAAGAGTGTGTTCCTCCAACCATTGGCTGTCTGCATTACACGGAAAGTTCAATTTACACCTCGGAAAG
ATTCCAGAATTGGAAGCGGATCACTGTCTACCTTCCACTCTCCACCATTTCTCCCAGGACCCGGTTCAGATGGATTCAGGCCAACTACAC
TGTGGGGGCTGATTCCTGGGCGATTGATAATGTTGTACTGGCCTCAGGGTGCCCTTGGATGTGCTCAGGACGAGGGATTTGTGATGCTGG
ACGCTGTGTGTGTGACCGGGGCTTTGGTGGACCCTATTGTGTTCCTGTTGTTCCTCTGCCCTCGATTCTTAAAGACGATTTCAATGGGAA
TTTACATCCTGACCTTTGGCCTGAAGTGTATGGTGCAGAGAGGGGGAATCTGAATGGTGAAACCATCAAATCTGGAACATCTCTAATTTT
TAAAGGGGAAGGACTAAGGATGCTTATTTCAAGAGATCTAGATTGTACAAATACAATGTATGTCCAGTTTTCACTTAGATTTATAGCAAA
AAGTACCCCAGAGAGATCTCACTCTATTCTGTTACAATTCTCCATCAGTGGAGGAATCACTTGGCACCTGATGGATGAATTTTACTTTCC
TCAAACAACGAATATACTTTTCATCAATGTTCCCTTGCCATACACTGCCCAAACCAATGCTACAAGATTCAGACTCTGGCAACCTTATAA
TAACGGTAAGAAAGAAGAAATCTGGATTGTTGATGACTTCATTATCGATGGAAATAATGTAAACAACCCTGTGATGCTCTTGGATACATT
TGATTTTGGGCCCAGAGAAGACAATTGGTTTTTCTATCCTGGTGGTAACATCGGTCTTTATTGTCCATATTCTTCAAAGGGGGCACCTGA
AGAAGATTCAGCTATGGTGTTTGTTTCAAATGAAGTTGGTGAGCATTCCATTACCACCCGTGACCTAAATGTGAATGAGAACACCATCAT
ACAATTTGAGATCAACGTTGGCTGTTCGACTGATAGCTCATCCGCGGATCCAGTGAGACTGGAATTTTCAAGGGACTTCGGGGCGACCTG
GCACCTTCTGCTGCCCCTCTGCTACCACAGCAGCAGCCACGTCAGCTCTTTATGCTCCACCGAGCACCACCCCAGCAGCACCTACTACGC
AGGAACCATGCAGGGCTGGAGGAGGGAGGTCGTGCACTTTGGGAAGCTGCACCTTTGTGGATCTGTCCGTTTCAGATGGTACCAGGGATT
TTACCCTGCCGGCTCTCAGCCAGTGACATGGGCCATTGATAATGTCTACATCGGTCCCCAGTGTGAGGAGATGTGTAATGGACAGGGGAG
CTGTATCAATGGAACCAAATGTATATGTGACCCTGGCTACTCAGGTCCAACCTGTAAAATAAGCACCAAAAATCCTGATTTTCTCAAAGA
TGATTTCGAAGGTCAGCTAGAATCTGATAGATTCTTATTAATGAGTGGTGGGAAACCATCTCGAAAGTGTGGAATCCTTTCTAGTGGAAA
CAACCTCTTTTTCAATGAAGATGGCTTGCGCATGTTGATGACACGAGACCTGGATTTATCACATGCTAGATTTGTGCAGTTCTTCATGAG
ACTGGGATGTGGTAAAGGCGTTCCTGACCCCAGGAGTCAACCCGTGCTCCTACAGTATTCTCTCAACGGTGGCCTCTCGTGGAGTCTTCT
TCAGGAGTTCCTTTTCAGCAATTCCAGCAATGTGGGCAGGTACATTGCCCTGGAGATACCCTTGAAAGCCCGTTCTGGTTCTACTCGCCT
TCGCTGGTGGCAACCGTCTGAGAATGGGCACTTCTACAGCCCCTGGGTTATCGATCAGATTCTTATTGGAGGAAATATTTCTGGTAATAC
GGTCTTGGAAGATGATTTCACAACCCTTGATAGTAGGAAATGGCTGCTTCACCCAGGAGGCACCAAGATGCCCGTGTGTGGCTCTACTGG
TGATGCCCTGGTCTTCATTGAAAAGGCCAGCACCCGTTACGTGGTCAGCACAGACGTTGCCGTGAATGAGGATTCCTTCCTACAGATAGA
CTTCGCTGCCTCCTGCTCAGTCACAGACTCTTGTTATGCGATTGAATTGGAATACTCAGTAGATCTTGGATTGTCATGGCACCCATTGGT
AAGGGACTGTCTGCCTACCAATGTGGAATGCAGTCGCTATCATCTGCAACGGATCCTGGTGTCAGACACTTTCAACAAGTGGACTAGAAT
CACTCTGCCTCTCCCTCCTTATACCAGGTCCCAAGCCACTCGTTTCCGTTGGCATCAACCAGCTCCTTTTGACAAGCAGCAGACATGGGC
AATAGATAATGTCTATATCGGGGATGGCTGCATAGACATGTGCAGTGGCCATGGGAGATGCATCCAGGGAAACTGCGTCTGTGATGAACA
GTGGGGTGGCCTGTACTGTGATGACCCCGAGACCTCTCTTCCAACCCAACTCAAAGACAACTTCAATCGAGCTCCATCCAGTCAGAACTG
GCTGACTGTGAACGGAGGGAAATTGAGTACAGTGTGTGGAGCCGTGGCGTCGGGAATGGCTCTCCATTTCAGTGGGGGTTGTAGTCGATT
ATTAGTCACTGTGGATCTAAACCTCACTAATGCTGAGTTCATCCAATTTTACTTCATGTATGGGTGCCTGATTACACCAAACAACCGTAA
CCAAGGTGTTCTCTTGGAATATTCTGTCAATGGAGGCATTACCTGGAACCTGCTCATGGAGATTTTCTATGACCAGTACAGTAAGCCCGG
ATTTGTGAATATCCTTCTCCCTCCTGATGCTAAAGAGATTGCCACTCGCTTCCGCTGGTGGCAGCCAAGACATGACGGCCTGGATCAGAA
CGACTGGGCCATTGACAATGTCCTCATCTCAGGCTCTGCTGACCAAAGGACCGTTATGCTGGACACCTTCAGCAGCGCCCCAGTACCCCA
GCATGAGCGCTCCCCTGCAGATGCCGGCCCTGTCGGGAGGATCGCCTTTGACATGTTTATGGAAGACAAAACTTCAGTGAATGAGCACTG
GCTATTCCATGATGATTGTACAGTAGAAAGATTCTGTGACTCCCCTGATGGTGTGATGCTCTGTGGCAGTCATGATGGACGGGAGGTGTA
TGCAGTGACCCATGACCTGACTCCCACTGAAGGCTGGATTATGCAATTCAAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTAGTAAGCACTCG
CAAACAAAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATG
AAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAA
TATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGAC
TTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAA
TAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACA
TTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTA
TTCTCTTCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCA
GAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAG
CGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTC
CCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGA
TTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTAC
AACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAG

>68686_68686_3_PRKAR2B-RELN_PRKAR2B_chr7_106710761_ENST00000265717_RELN_chr7_103393661_ENST00000428762_length(amino acids)=3393AA_BP=113
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEE
EEAAPADAGAFNAPVINRFTRRASAPTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYG
PRELITTGLNTTTASVLQFSIGSGSCRFSYSDPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGE
VYEACWALDNILIINSAHRQVVLEDSLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGNEGSEFNFATTRDVDLSTEDIQEQWSEEFESQ
PTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNSHENDIILYAKIEGRKEHITLDTLSYSSY
KVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTE
CLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSG
PACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA
PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMTSVLFNSISLDFTNLV
EVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQEEC
LPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDSIYIGQQCPNMCSGHGSCDHGICRCDQGYQGT
ECHPEAALPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCNKPD
SREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQIIPVINPTLPQ
NFYEKPAFDYPMNQMSVWLMLANEGMVKNETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDA
GMSWFLVKEGCYPASAGKGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCS
GHGDCISGVCFCDLGYTAAQGTCVSNVPNHNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQ
FYIQIGSKTSGITCIKPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG
MNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYS
LNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVLASGCPWMCSGRGI
CDAGRCVCDRGFGGPYCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLR
FIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGNNVNNPVML
LDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFSRDF
GATWHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCN
GQGSCINGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQ
FFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNI
SGNTVLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSW
HPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGRCIQGNCV
CDEQWGGLYCDDPETSLPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITP
NNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSA
PVPQHERSPADAGPVGRIAFDMFMEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRKAR2B-RELN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRKAR2B-RELN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRKAR2B-RELN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource