FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRKCZ-SKI (FusionGDB2 ID:68798)

Fusion Gene Summary for PRKCZ-SKI

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKCZ-SKI
Fusion gene ID: 68798
HgeneTgene
Gene symbol

PRKCZ

SKI

Gene ID

5590

6497

Gene nameprotein kinase C zetaSKI proto-oncogene
SynonymsPKC-ZETA|PKC2SGS|SKV
Cytomap

1p36.33

1p36.33-p36.32

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C zeta typenPKC-zetaski oncogeneproto-oncogene c-Skiski oncoproteinv-ski avian sarcoma viral oncogene homolog
Modification date2020032720200329
UniProtAcc.

SKIDA1,C10orf140

Ensembl transtripts involved in fusion geneENST00000479263, ENST00000400920, 
ENST00000400921, 		ENST00000378536, 
ENST00000478223, 
Fusion gene scores* DoF score11 X 7 X 6=46217 X 5 X 6=510
# samples 1217
** MAII scorelog2(12/462*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/510*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKCZ [Title/Abstract] AND SKI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKI(2161174)-PRKCZ(2087434), # samples:2
SKI(2161174)-PRKCZ(2066701), # samples:2
PRKCZ(1991030)-SKI(2234416), # samples:1
PRKCZ(2106752)-SKI(2234417), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCZ

GO:0006468

protein phosphorylation

10770950|17313651

HgenePRKCZ

GO:0018105

peptidyl-serine phosphorylation

15069075

TgeneSKI

GO:0000122

negative regulation of transcription by RNA polymerase II

17469184

TgeneSKI

GO:0008285

negative regulation of cell proliferation

11430826

TgeneSKI

GO:0014902

myotube differentiation

19008232

TgeneSKI

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

17469184

TgeneSKI

GO:0030514

negative regulation of BMP signaling pathway

14699069

TgeneSKI

GO:0032926

negative regulation of activin receptor signaling pathway

14699069

TgeneSKI

GO:0043388

positive regulation of DNA binding

15107821

TgeneSKI

GO:0045668

negative regulation of osteoblast differentiation

14699069

TgeneSKI

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across PRKCZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1783PRKCZchr1

1991030

+SKIchr1

2234416

+
ChimerDB4STADTCGA-HU-A4GN-01APRKCZchr1

2106752

+SKIchr1

2234417

+


Top

Fusion Gene ORF analysis for PRKCZ-SKI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479263ENST00000378536PRKCZchr1

2106752

+SKIchr1

2234417

+
3UTR-3UTRENST00000479263ENST00000478223PRKCZchr1

2106752

+SKIchr1

2234417

+
5CDS-3UTRENST00000400920ENST00000478223PRKCZchr1

2106752

+SKIchr1

2234417

+
5CDS-3UTRENST00000400921ENST00000478223PRKCZchr1

2106752

+SKIchr1

2234417

+
In-frameENST00000400920ENST00000378536PRKCZchr1

2106752

+SKIchr1

2234417

+
In-frameENST00000400921ENST00000378536PRKCZchr1

2106752

+SKIchr1

2234417

+
intron-3CDSENST00000400920ENST00000378536PRKCZchr1

1991030

+SKIchr1

2234416

+
intron-3CDSENST00000400921ENST00000378536PRKCZchr1

1991030

+SKIchr1

2234416

+
intron-3CDSENST00000479263ENST00000378536PRKCZchr1

1991030

+SKIchr1

2234416

+
intron-3UTRENST00000400920ENST00000478223PRKCZchr1

1991030

+SKIchr1

2234416

+
intron-3UTRENST00000400921ENST00000478223PRKCZchr1

1991030

+SKIchr1

2234416

+
intron-3UTRENST00000479263ENST00000478223PRKCZchr1

1991030

+SKIchr1

2234416

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400921PRKCZchr12106752+ENST00000378536SKIchr12234417+628117094432926827
ENST00000400920PRKCZchr12106752+ENST00000378536SKIchr12234417+59931421442638864

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400921ENST00000378536PRKCZchr12106752+SKIchr12234417+0.0030631270.9969369
ENST00000400920ENST00000378536PRKCZchr12106752+SKIchr12234417+0.002683080.9973169

Top

Fusion Genomic Features for PRKCZ-SKI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRKCZchr12106752+SKIchr12234416+0.9996580.000341994
PRKCZchr12106752+SKIchr12234416+0.9996580.000341994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PRKCZ-SKI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:2161174/chr1:2087434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SKI

SKIDA1,C10orf140

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.908

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+131515_98342410.0DomainPB1
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+131515_98342410.0DomainPB1
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+1315258_266342410.0Nucleotide bindingATP
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+1315258_266342410.0Nucleotide bindingATP
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+1315130_180342410.0Zinc fingerPhorbol-ester/DAG-type
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+1315130_180342410.0Zinc fingerPhorbol-ester/DAG-type
TgeneSKIchr1:2106752chr1:2234417ENST0000037853607536_710323729.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+1315252_518342410.0DomainProtein kinase
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+1315519_590342410.0DomainAGC-kinase C-terminal
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+1315252_518342410.0DomainProtein kinase
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+1315519_590342410.0DomainAGC-kinase C-terminal


Top

Fusion Gene Sequence for PRKCZ-SKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68798_68798_1_PRKCZ-SKI_PRKCZ_chr1_2106752_ENST00000400920_SKI_chr1_2234417_ENST00000378536_length(transcript)=5993nt_BP=1421nt
AGAACATCGCTCGGTGCCAGACAGGCAGGACGCAGCGGGCTGGCCTGCGGGGCTCACTGCTGCCCCCCGGGGCCGAGCACGAAAGGGAGA
GTTGGAGGGCGCTTCCTCGCCGGGTGTTGCGGTGTGAGCGGGGACTGGTGAGTGTGTGCTGTCTTCAGAGAGAGAAGAGCAGTTTTCAGG
AATCTATCTACCGCCGGGGAGCCAGAAGATGGAGGAAGCTGTACCGTGCCAACGGCCACCTCTTCCAAGCCAAGCGCTTTAACAGGAGAG
CGTACTGCGGTCAGTGCAGCGAGAGGATATGGGGCCTCGCGAGGCAAGGCTACAGGTGCATCAACTGCAAACTGCTGGTCCATAAGCGCT
GCCACGGCCTCGTCCCGCTGACCTGCAGGAAGCATATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTAGACGACAAGAACGAGGACG
CCGACCTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAGCATGACAGCATTAAAGACGACTCGGAGGACCTTA
AGCCAGTTATCGATGGGATGGATGGAATCAAAATCTCTCAGGGGCTTGGGCTGCAGGACTTTGACCTAATCAGAGTCATCGGGCGCGGGA
GCTACGCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTGAAGAAAGAGCTGGTGCATGATGACG
AGGATATTGACTGGGTACAGACAGAGAAGCACGTGTTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGATTACACTCCTGCTTCCAGA
CGACAAGTCGGTTGTTCCTGGTCATTGAGTACGTCAACGGCGGGGACCTGATGTTCCACATGCAGAGGCAGAGGAAGCTCCCTGAGGAGC
ACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCCCTCAACTTCCTGCACGAGAGGGGGATCATCTACAGGGACCTGAAGCTGGACAACG
TCCTCCTGGATGCGGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGCCCTGGTGACACAACGAGCACTTTCT
GCGGAACCCCGAATTACATCGCCCCCGAAATCCTGCGGGGAGAGGAGTACGGGTTCAGCGTGGACTGGTGGGCGCTGGGAGTCCTCATGT
TTGAGATGATGGCCGGGCGCTCCCCGTTCGACATCATCACCGACAACCCGGACATGAACACAGAGGACTACCTTTTCCAAGTGATCCTGG
AGAAGCCCATCCGGATCCCCCGGTTCCTGTCCGTCAAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGGACCCCAAAGAGAGGCTCG
GCTGCCGGCCACAGACTGGATTTTCTGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGGGACTTGGTCTCCTCTGAGCCTCCGG
CCTCCATAAGACCCAAAACAGATGACACCTCTTCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCAGCTGGCTGCGGACCTTGG
CCGGCTCTTCCAATAAGAGCCTGGGCTGTGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGACCCTGGTCCCCCGCAGTGTCAGCGAGTG
AGAAAGAGCTCTCCCCACACCTCCCGGCCCTCATCCGAGACAGCTTCTACTCCTACAAGAGCTTTGAGACAGCCGTGGCGCCCAACGTGG
CCCTCGCACCGCCGGCCCAGCAGAAGGTTGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCCCGGGCCCCCGAGCCTCTCGCCACTTGCA
CCCAGCCTCGGAAGCGGAAGCTGACTGTGGACACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCCCAGAGGAGGACAAGGACT
CGGAGGCGGAGGTGGAAGTTGAAAGCAGGGAGGAATTCACCTCCTCCTTGTCCTCGCTCTCTTCCCCGTCCTTTACCTCATCCAGCTCCG
CCAAGGACCTGGGCTCCCCGGGTGCGCGTGCCCTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACGCCCCCAGTGGGCTGGAGG
CGGAGCTGGAGCACCTGCGGCAGGCACTGGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAGAAGTTCCTGCATGAGGTGGTCAAGATGC
GCGTGAAGCAGGAGGAGAAGCTCAGCGCAGCCCTGCAGGCCAAGCGCAGCCTCCACCAGGAGCTGGAGTTCCTACGCGTGGCCAAGAAGG
AGAAGCTGCGGGAGGCCACGGAGGCCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACGAGAAGAAGATGAAAGAGG
CCAACGAGTCACGGCTGCGCCTGAAGCGGGAGCTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCTGCGAGGCGGGCCGCCTGC
GCGCCAAGTACTCGGCCCAGATCGAAGACCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGACCGGGAGCAGCTGCGGGCCGACCTGCTGC
GGGAGCGCGAGGCCCGGGAGCACCTGGAGAAGGTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCCGCCCCGAGGCTGCGGGCA
GCGAGGGCGCTGCGGAGCTGGAGCCGTAGATTCCGTGCCTGCCGCCGCAGCGCCGCCGACAACGCGGGTGCAGGGGGGCGCGGCTGGGCG
GTGCAGCTCCGCCCGGCTCCGCCCCTGCAGCCCACACAGCACAACGTCTTACCGTGCCTATTACCAAGCGAGTGTTTGTAACCATGTAGT
TTTGGAACCCACTGCAAAATTTTCTACTGGCCAAGTTCAAGTGAGTAAGCCGCGTCCCCCAACTACAGCTGGAGACGGGGCCAGCTCGGC
GGCCTGCTGGTCCTCTGCTTGCTGGAACATTCTAACATTTACACTTTTGTTATAAGCTATTTAAAACCAGTAAGGAGACTTGAAATTCAG
AAAATCAACACATTTTTAAATGACTAACTTCTAAAAGCCCCAACACATGACGCCATCTGAAGACCCGCAACGGAGTGGGGGTGGCGGCCG
CCCCACCCTCCCCACCCGGGGAAGCCATCACAGCTCATCTGCCCGCGGCTGCGTGAGGACAGCAGGGGTTTTTCTTCAGAGTCTATTTTT
TCAGCGACAAGGACCCAGGTCTTCCTGCTGCTGCCAGGGAGAGCAGGGACAGTGCCGCGTGCGAGATGAGCTCGAACACTGCCCGCCTTA
CTGCCGCCTACCCCGCCCGCCACGCCGCCGTCGATGCCAGCGCTGTCCCCACGGGTACCAGGAAGTGCAGAGCCGCACAGGAGCTGCCCC
GGAGCTGAGGGGACGGTCTTCGGCTCCTCTGCACCCCGTGATTCTGCCCACGCTCCTCCACCACGAGGCACTGACCTGCGTCGGGTGGTG
ACCGTGGCTGGCGGTCACGCCCTCAGCCCCTCCGGGCACACGTGCCGCCTGACCGGGCGACCCTTTTCAGTTCGGCAAACGTCGCTCCCT
TCATTTTGGGACTGAGGCTGCAGCATTGGAACAAAAGAGCATTATTTCAATTTTTCTTTCTTTTTTTTTGTTCGTTCATTTAAACGTATA
TTTAGAACTGCACTTTGTCCACAACCTTCCCTTCTCTTTCTATTCCCCAGTGAACTGAGGTTTTTACCGATTTATAGAGCAGTCAAATCC
GAAGTGCTCGAGTGCTTAGAAACCCCCTCTGGTGCTTGGTTGAACAAGGGAATCACAAGAAAACGAAAATGCAAAAACTGAACTTCGGGG
GTCGTTCTGTGCCTTCCAGCATCTTGTACAGCAAATCCTGACTCGTGTCTTTTTACCCCCAAGATATCTGTCTTCAGTAGCGACTGAATC
TGCCACTCTCAGAATAAGTTCCTTGCATTTATTCCAAATAATCTCGTTTACTCTCACCTGTTTATGCAAATTGTATAAGGTTTCTTATGC
CCAAGCTTGAAAAATGATTTCCCAGTAGACAAGAGGCGGCTACCTATCCTACAGTTACGGTATTTATTTACATAAGAAGATCTTACAGGA
GTTCTTTGCTTGAATCCGTTCTAACACCCGCGGCAGCTGCACGCGCTCACAGAAGGTGGAGGTTACTTGCCCAGGTACAGACGACCTCGG
GGCAGTGACGAGCAAAGACCAGAGACTGCTGAGCCCTCGCATCTGGGTGGCGGAATTGCCTGCGGGGTTTTGCCCTTGGTTTACTGAGGG
GGGTCTTGGTTGCTGCTGAAGCCCCCCACCCCTTCTAAAGTGCAATGCAAAAGGGACATCATGTATATGCAGCGTTTGTTTGGAATTTTC
TTTGCTTTTGTTTTCTTTGCGGTTGTTCTGTGTGCATGGATTCCACACCTCTGCCGTAGGTAGATCCGTCAGCGGGCATTATTACCGTGT
CTTGTAAAGGGTCGGTTTTGTTATGCAACATGCAGAATGCTGTTTTTAGCCTTGTTTTACCAGAGTTGTTTTTTTTTTCAGTTATTTCTT
CAAGGGAAACTAAATGATTTAGTTGGAGCAAAGCTTTAAGTGTGTTGGCGTGCTTCTGTGTGGCTGTCCTGTGTCGCCAGGTCGAAGATC
ACAGTGAGGTAGAGGCCCTGCCCCATCCCCAGGGCCGCCAGGCTTGCTCCGTTTGCTTTGAGTTTTTAGACCCCAGAGGGAGATGAGCTT
TTCCAAGCTGTGTCTGGGCCAGAGCCTCTCCTTGCCCTTGCTCCATCCCGACGGTCACCGTTGGGTCCACGCCTCCACCGCCCCATCTTG
CCCCAAACGGAAAGCGCTGTATCTGCAGTGGCAGCCCTTCCCCACTTCGGCTCTGGGAGGGTCCAGCCAGTGTCACCTGGGCCCACCCTT
TCCTGCAGCTGCCAGGCCCGTGCGGTCAGTGGGACCCGGACGTGGGCAGGCGAGCTCGGGACCCTCCCAGGCAGTTCCCACAGCTCTTGC
CTCGGCTCACCAGGGTCACTTCCACTGTCAGGGGCCTGAGGGGGCAGCTGTGGCTGCAGGGCTGCTCTGGACTGAGGGGTCCCAGGCCCC
GAGGGGTGCACGCCTGGCTCCCCTTGGCACAGGTGCGAGTCCGTTTCTTTTCAGCAGAAGGGGGAAGAGGTGTCCGCTGTGTGGGCTGCT
GACTCCTCTGTGTGTGAGGCCCTTCATCTAAGTGATTGTGTATTCAGTTTAATTCTCATTATATTTCTATACTGAAAGAAGATTTTTAAC
GAAGGGAAAAACAACAGCAATAACATTCATATCTCTGGAGCAGCTAACTCATACACGTAATGTCTGCTTTTCGTACAGAACTAGCCAATG
TAAAAACAGTTCACCTGTAAATACTTTTTCCTTTTTCACCGTTGTATTATACATGTATATGCTGGGTCCTTTTTCAGAAACTCTTTTCTT
ACCTGAGAGTTGTCTTGTTTTCTGGGCTGTTTTTAACTGAGGAAAAAAAAAATGCTTTCCTGCCGGGGGGCAGGGGAGACGGAGAAACCC
ATGTGCGTTTCCCATGTGACCCCCTCCTCCCTGTGGGTCTGAGCCCCGGCCCCCCCCACCTCCTCCTCCCTGTGGGTCCGAACCCCGGCC
CCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGATCCCCGGCCCCCCCCACCCCCTC
CTCCCTGTGGGTCCGAACCCCGGCCCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCTCCCTCAGCCCACC
AGGGTCCAGGGAGATGTTCGTTCTCGCTTTAAGTCAGGAGTCACAAATGACTTTTTTTTTTCAATTAAGGAAAAAGCTCCATCTCTACCT
TTAACATCACCCAGACCCCCGCCCCTGCCCGTGCCCCACGCTGCTGCTAACGACAGTATGATGCTTACTCTGCTACTCGGAAACTATTTT

>68798_68798_1_PRKCZ-SKI_PRKCZ_chr1_2106752_ENST00000400920_SKI_chr1_2234417_ENST00000378536_length(amino acids)=864AA_BP=1
MRGSLLPPGAEHERESWRALPRRVLRCERGLVSVCCLQREKSSFQESIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLAR
QGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQG
LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGG
DLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE
EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHA
FFRSIDWDLVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDS
FYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTS
SLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAK
RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKL

--------------------------------------------------------------
>68798_68798_2_PRKCZ-SKI_PRKCZ_chr1_2106752_ENST00000400921_SKI_chr1_2234417_ENST00000378536_length(transcript)=6281nt_BP=1709nt
CTGGCAGGCCAACCTGCAGGACCCCGGGCTTAGCTGGGTTCTGTTCTGATGTCGCATTTTCAAGGTCCGCTGAGTCCGAGCCCTGCCTGG
GTCTGGCTGCTGCCCGCCCGCTCTCTGGACTGTGCTGATGCAGAGATGCTTGTTTTCCTGTGACGTCAGCGTCAGCTCCTGCACATCCAT
GCCGTGTTTTAGTTTGTGCCTCAGCTGCTGGCTACAGCTTCCCGGGGGAGCCGGGTACCACCCGGGCCTGGAGACATGAGGAGGCAGGGA
TGTGAGGGGCGGGGGACAGGACAGCCGGCCTTCCGTTAAATATCTGCTCCTCGCGCTCGAGCCTCCCTGCCTATTGTCGGGGCCGGAGGC
GAGCCGACGCAGCATCAGCTCGTCAACGGGAAGGAAGATGCCTCCCTGCACGCCCGCCGCGCACAGAGCATAAAGAATCTGCGCTGAGGA
GGCAGGAGAAGAAAGCCGAATCTATCTACCGCCGGGGAGCCAGAAGATGGAGGAAGCTGTACCGTGCCAACGGCCACCTCTTCCAAGCCA
AGCGCTTTAACAGGAGAGCGTACTGCGGTCAGTGCAGCGAGAGGATATGGGGCCTCGCGAGGCAAGGCTACAGGTGCATCAACTGCAAAC
TGCTGGTCCATAAGCGCTGCCACGGCCTCGTCCCGCTGACCTGCAGGAAGCATATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTAG
ACGACAAGAACGAGGACGCCGACCTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAGCATGACAGCATTAAAG
ACGACTCGGAGGACCTTAAGCCAGTTATCGATGGGATGGATGGAATCAAAATCTCTCAGGGGCTTGGGCTGCAGGACTTTGACCTAATCA
GAGTCATCGGGCGCGGGAGCTACGCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTGAAGAAAG
AGCTGGTGCATGATGACGAGGATATTGACTGGGTACAGACAGAGAAGCACGTGTTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGAT
TACACTCCTGCTTCCAGACGACAAGTCGGTTGTTCCTGGTCATTGAGTACGTCAACGGCGGGGACCTGATGTTCCACATGCAGAGGCAGA
GGAAGCTCCCTGAGGAGCACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCCCTCAACTTCCTGCACGAGAGGGGGATCATCTACAGGG
ACCTGAAGCTGGACAACGTCCTCCTGGATGCGGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGCCCTGGTG
ACACAACGAGCACTTTCTGCGGAACCCCGAATTACATCGCCCCCGAAATCCTGCGGGGAGAGGAGTACGGGTTCAGCGTGGACTGGTGGG
CGCTGGGAGTCCTCATGTTTGAGATGATGGCCGGGCGCTCCCCGTTCGACATCATCACCGACAACCCGGACATGAACACAGAGGACTACC
TTTTCCAAGTGATCCTGGAGAAGCCCATCCGGATCCCCCGGTTCCTGTCCGTCAAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGG
ACCCCAAAGAGAGGCTCGGCTGCCGGCCACAGACTGGATTTTCTGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGGGACTTGG
TCTCCTCTGAGCCTCCGGCCTCCATAAGACCCAAAACAGATGACACCTCTTCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCA
GCTGGCTGCGGACCTTGGCCGGCTCTTCCAATAAGAGCCTGGGCTGTGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGACCCTGGTCCC
CCGCAGTGTCAGCGAGTGAGAAAGAGCTCTCCCCACACCTCCCGGCCCTCATCCGAGACAGCTTCTACTCCTACAAGAGCTTTGAGACAG
CCGTGGCGCCCAACGTGGCCCTCGCACCGCCGGCCCAGCAGAAGGTTGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCCCGGGCCCCCG
AGCCTCTCGCCACTTGCACCCAGCCTCGGAAGCGGAAGCTGACTGTGGACACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCC
CAGAGGAGGACAAGGACTCGGAGGCGGAGGTGGAAGTTGAAAGCAGGGAGGAATTCACCTCCTCCTTGTCCTCGCTCTCTTCCCCGTCCT
TTACCTCATCCAGCTCCGCCAAGGACCTGGGCTCCCCGGGTGCGCGTGCCCTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACG
CCCCCAGTGGGCTGGAGGCGGAGCTGGAGCACCTGCGGCAGGCACTGGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAGAAGTTCCTGC
ATGAGGTGGTCAAGATGCGCGTGAAGCAGGAGGAGAAGCTCAGCGCAGCCCTGCAGGCCAAGCGCAGCCTCCACCAGGAGCTGGAGTTCC
TACGCGTGGCCAAGAAGGAGAAGCTGCGGGAGGCCACGGAGGCCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACG
AGAAGAAGATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGAAGCGGGAGCTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCT
GCGAGGCGGGCCGCCTGCGCGCCAAGTACTCGGCCCAGATCGAAGACCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGACCGGGAGCAGC
TGCGGGCCGACCTGCTGCGGGAGCGCGAGGCCCGGGAGCACCTGGAGAAGGTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCC
GCCCCGAGGCTGCGGGCAGCGAGGGCGCTGCGGAGCTGGAGCCGTAGATTCCGTGCCTGCCGCCGCAGCGCCGCCGACAACGCGGGTGCA
GGGGGGCGCGGCTGGGCGGTGCAGCTCCGCCCGGCTCCGCCCCTGCAGCCCACACAGCACAACGTCTTACCGTGCCTATTACCAAGCGAG
TGTTTGTAACCATGTAGTTTTGGAACCCACTGCAAAATTTTCTACTGGCCAAGTTCAAGTGAGTAAGCCGCGTCCCCCAACTACAGCTGG
AGACGGGGCCAGCTCGGCGGCCTGCTGGTCCTCTGCTTGCTGGAACATTCTAACATTTACACTTTTGTTATAAGCTATTTAAAACCAGTA
AGGAGACTTGAAATTCAGAAAATCAACACATTTTTAAATGACTAACTTCTAAAAGCCCCAACACATGACGCCATCTGAAGACCCGCAACG
GAGTGGGGGTGGCGGCCGCCCCACCCTCCCCACCCGGGGAAGCCATCACAGCTCATCTGCCCGCGGCTGCGTGAGGACAGCAGGGGTTTT
TCTTCAGAGTCTATTTTTTCAGCGACAAGGACCCAGGTCTTCCTGCTGCTGCCAGGGAGAGCAGGGACAGTGCCGCGTGCGAGATGAGCT
CGAACACTGCCCGCCTTACTGCCGCCTACCCCGCCCGCCACGCCGCCGTCGATGCCAGCGCTGTCCCCACGGGTACCAGGAAGTGCAGAG
CCGCACAGGAGCTGCCCCGGAGCTGAGGGGACGGTCTTCGGCTCCTCTGCACCCCGTGATTCTGCCCACGCTCCTCCACCACGAGGCACT
GACCTGCGTCGGGTGGTGACCGTGGCTGGCGGTCACGCCCTCAGCCCCTCCGGGCACACGTGCCGCCTGACCGGGCGACCCTTTTCAGTT
CGGCAAACGTCGCTCCCTTCATTTTGGGACTGAGGCTGCAGCATTGGAACAAAAGAGCATTATTTCAATTTTTCTTTCTTTTTTTTTGTT
CGTTCATTTAAACGTATATTTAGAACTGCACTTTGTCCACAACCTTCCCTTCTCTTTCTATTCCCCAGTGAACTGAGGTTTTTACCGATT
TATAGAGCAGTCAAATCCGAAGTGCTCGAGTGCTTAGAAACCCCCTCTGGTGCTTGGTTGAACAAGGGAATCACAAGAAAACGAAAATGC
AAAAACTGAACTTCGGGGGTCGTTCTGTGCCTTCCAGCATCTTGTACAGCAAATCCTGACTCGTGTCTTTTTACCCCCAAGATATCTGTC
TTCAGTAGCGACTGAATCTGCCACTCTCAGAATAAGTTCCTTGCATTTATTCCAAATAATCTCGTTTACTCTCACCTGTTTATGCAAATT
GTATAAGGTTTCTTATGCCCAAGCTTGAAAAATGATTTCCCAGTAGACAAGAGGCGGCTACCTATCCTACAGTTACGGTATTTATTTACA
TAAGAAGATCTTACAGGAGTTCTTTGCTTGAATCCGTTCTAACACCCGCGGCAGCTGCACGCGCTCACAGAAGGTGGAGGTTACTTGCCC
AGGTACAGACGACCTCGGGGCAGTGACGAGCAAAGACCAGAGACTGCTGAGCCCTCGCATCTGGGTGGCGGAATTGCCTGCGGGGTTTTG
CCCTTGGTTTACTGAGGGGGGTCTTGGTTGCTGCTGAAGCCCCCCACCCCTTCTAAAGTGCAATGCAAAAGGGACATCATGTATATGCAG
CGTTTGTTTGGAATTTTCTTTGCTTTTGTTTTCTTTGCGGTTGTTCTGTGTGCATGGATTCCACACCTCTGCCGTAGGTAGATCCGTCAG
CGGGCATTATTACCGTGTCTTGTAAAGGGTCGGTTTTGTTATGCAACATGCAGAATGCTGTTTTTAGCCTTGTTTTACCAGAGTTGTTTT
TTTTTTCAGTTATTTCTTCAAGGGAAACTAAATGATTTAGTTGGAGCAAAGCTTTAAGTGTGTTGGCGTGCTTCTGTGTGGCTGTCCTGT
GTCGCCAGGTCGAAGATCACAGTGAGGTAGAGGCCCTGCCCCATCCCCAGGGCCGCCAGGCTTGCTCCGTTTGCTTTGAGTTTTTAGACC
CCAGAGGGAGATGAGCTTTTCCAAGCTGTGTCTGGGCCAGAGCCTCTCCTTGCCCTTGCTCCATCCCGACGGTCACCGTTGGGTCCACGC
CTCCACCGCCCCATCTTGCCCCAAACGGAAAGCGCTGTATCTGCAGTGGCAGCCCTTCCCCACTTCGGCTCTGGGAGGGTCCAGCCAGTG
TCACCTGGGCCCACCCTTTCCTGCAGCTGCCAGGCCCGTGCGGTCAGTGGGACCCGGACGTGGGCAGGCGAGCTCGGGACCCTCCCAGGC
AGTTCCCACAGCTCTTGCCTCGGCTCACCAGGGTCACTTCCACTGTCAGGGGCCTGAGGGGGCAGCTGTGGCTGCAGGGCTGCTCTGGAC
TGAGGGGTCCCAGGCCCCGAGGGGTGCACGCCTGGCTCCCCTTGGCACAGGTGCGAGTCCGTTTCTTTTCAGCAGAAGGGGGAAGAGGTG
TCCGCTGTGTGGGCTGCTGACTCCTCTGTGTGTGAGGCCCTTCATCTAAGTGATTGTGTATTCAGTTTAATTCTCATTATATTTCTATAC
TGAAAGAAGATTTTTAACGAAGGGAAAAACAACAGCAATAACATTCATATCTCTGGAGCAGCTAACTCATACACGTAATGTCTGCTTTTC
GTACAGAACTAGCCAATGTAAAAACAGTTCACCTGTAAATACTTTTTCCTTTTTCACCGTTGTATTATACATGTATATGCTGGGTCCTTT
TTCAGAAACTCTTTTCTTACCTGAGAGTTGTCTTGTTTTCTGGGCTGTTTTTAACTGAGGAAAAAAAAAATGCTTTCCTGCCGGGGGGCA
GGGGAGACGGAGAAACCCATGTGCGTTTCCCATGTGACCCCCTCCTCCCTGTGGGTCTGAGCCCCGGCCCCCCCCACCTCCTCCTCCCTG
TGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGATCCCC
GGCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCA
CCCCTCCCTCAGCCCACCAGGGTCCAGGGAGATGTTCGTTCTCGCTTTAAGTCAGGAGTCACAAATGACTTTTTTTTTTCAATTAAGGAA
AAAGCTCCATCTCTACCTTTAACATCACCCAGACCCCCGCCCCTGCCCGTGCCCCACGCTGCTGCTAACGACAGTATGATGCTTACTCTG

>68798_68798_2_PRKCZ-SKI_PRKCZ_chr1_2106752_ENST00000400921_SKI_chr1_2234417_ENST00000378536_length(amino acids)=827AA_BP=1
MRRQEKKAESIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEP
PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVV
KKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGII
YRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTE
DYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLVSSEPPASIRPKTDDTSSQSPAPSEKDK
PSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSR
APEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAP
ADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA
ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRKCZ-SKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePRKCZchr1:2106752chr1:2234417ENST00000400920+131579_145342.0410.0SQSTM1
HgenePRKCZchr1:2106752chr1:2234417ENST00000400921+131579_145342.0410.0SQSTM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRKCZ-SKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRKCZ-SKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource