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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRKD2-HPSE2 (FusionGDB2 ID:68814)

Fusion Gene Summary for PRKD2-HPSE2

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKD2-HPSE2
Fusion gene ID: 68814
HgeneTgene
Gene symbol

PRKD2

HPSE2

Gene ID

25865

60495

Gene nameprotein kinase D2heparanase 2 (inactive)
SynonymsHSPC187|PKD2|nPKC-D2HPA2|HPR2|UFS|UFS1
Cytomap

19q13.32

10q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase D2inactive heparanase-2heparanase 3heparanase-like protein
Modification date2020032920200313
UniProtAcc.

Q8WWQ2

Ensembl transtripts involved in fusion geneENST00000291281, ENST00000433867, 
ENST00000600194, ENST00000601806, 
ENST00000593492, ENST00000595515, 
ENST00000370546, ENST00000370549, 
ENST00000370552, ENST00000404542, 
Fusion gene scores* DoF score9 X 8 X 9=6489 X 8 X 3=216
# samples 119
** MAII scorelog2(11/648*10)=-2.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKD2 [Title/Abstract] AND HPSE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRKD2(47181653)-HPSE2(100249953), # samples:2
Anticipated loss of major functional domain due to fusion event.PRKD2-HPSE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRKD2-HPSE2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKD2-HPSE2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PRKD2-HPSE2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKD2

GO:0006468

protein phosphorylation

22228765

HgenePRKD2

GO:0018105

peptidyl-serine phosphorylation

18440775

HgenePRKD2

GO:0045944

positive regulation of transcription by RNA polymerase II

17077180

HgenePRKD2

GO:0046777

protein autophosphorylation

17077180

HgenePRKD2

GO:0050852

T cell receptor signaling pathway

17077180


check buttonFusion gene breakpoints across PRKD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HPSE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1740-01APRKD2chr19

47181653

-HPSE2chr10

100249953

-


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Fusion Gene ORF analysis for PRKD2-HPSE2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000291281ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000291281ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000291281ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000291281ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000433867ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000433867ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000433867ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
Frame-shiftENST00000433867ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000600194ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000600194ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000600194ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000600194ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000601806ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000601806ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000601806ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
In-frameENST00000601806ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000593492ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000593492ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000593492ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000593492ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000595515ENST00000370546PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000595515ENST00000370549PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000595515ENST00000370552PRKD2chr19

47181653

-HPSE2chr10

100249953

-
intron-3CDSENST00000595515ENST00000404542PRKD2chr19

47181653

-HPSE2chr10

100249953

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000601806PRKD2chr1947181653-ENST00000370549HPSE2chr10100249953-32742359512882943
ENST00000601806PRKD2chr1947181653-ENST00000370552HPSE2chr10100249953-32742359512882943
ENST00000601806PRKD2chr1947181653-ENST00000370546HPSE2chr10100249953-28882359512735894
ENST00000601806PRKD2chr1947181653-ENST00000404542HPSE2chr10100249953-28182359512816922
ENST00000600194PRKD2chr1947181653-ENST00000370549HPSE2chr10100249953-333624213622944860
ENST00000600194PRKD2chr1947181653-ENST00000370552HPSE2chr10100249953-333624213622944860
ENST00000600194PRKD2chr1947181653-ENST00000370546HPSE2chr10100249953-295024213622797811
ENST00000600194PRKD2chr1947181653-ENST00000404542HPSE2chr10100249953-288024213622878839

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000601806ENST00000370549PRKD2chr1947181653-HPSE2chr10100249953-0.0173464290.98265356
ENST00000601806ENST00000370552PRKD2chr1947181653-HPSE2chr10100249953-0.0173464290.98265356
ENST00000601806ENST00000370546PRKD2chr1947181653-HPSE2chr10100249953-0.0167483860.9832516
ENST00000601806ENST00000404542PRKD2chr1947181653-HPSE2chr10100249953-0.0270506980.97294927
ENST00000600194ENST00000370549PRKD2chr1947181653-HPSE2chr10100249953-0.0158329870.98416704
ENST00000600194ENST00000370552PRKD2chr1947181653-HPSE2chr10100249953-0.0158329870.98416704
ENST00000600194ENST00000370546PRKD2chr1947181653-HPSE2chr10100249953-0.0156615840.98433846
ENST00000600194ENST00000404542PRKD2chr1947181653-HPSE2chr10100249953-0.0236391780.9763608

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Fusion Genomic Features for PRKD2-HPSE2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKD2-HPSE2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:47181653/chr10:100249953)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HPSE2

Q8WWQ2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKD2chr19:47181653chr10:100249953ENST00000291281-1618397_509779879.0DomainPH
HgenePRKD2chr19:47181653chr10:100249953ENST00000433867-1719397_509779879.0DomainPH
HgenePRKD2chr19:47181653chr10:100249953ENST00000291281-1618557_565779879.0Nucleotide bindingATP
HgenePRKD2chr19:47181653chr10:100249953ENST00000433867-1719557_565779879.0Nucleotide bindingATP
HgenePRKD2chr19:47181653chr10:100249953ENST00000291281-1618138_188779879.0Zinc fingerPhorbol-ester/DAG-type 1
HgenePRKD2chr19:47181653chr10:100249953ENST00000291281-1618264_314779879.0Zinc fingerPhorbol-ester/DAG-type 2
HgenePRKD2chr19:47181653chr10:100249953ENST00000433867-1719138_188779879.0Zinc fingerPhorbol-ester/DAG-type 1
HgenePRKD2chr19:47181653chr10:100249953ENST00000433867-1719264_314779879.0Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKD2chr19:47181653chr10:100249953ENST00000291281-1618551_807779879.0DomainProtein kinase
HgenePRKD2chr19:47181653chr10:100249953ENST00000433867-1719551_807779879.0DomainProtein kinase


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Fusion Gene Sequence for PRKD2-HPSE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68814_68814_1_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370546_length(transcript)=2950nt_BP=2421nt
GTTCATTCAGCATCCCCTCCCACCTCCGCCAGGTTCCGGAAAATTCGAGGTGTCCACGCTCCCGGAGCCACTCTCCCTCCCACCCCAGCT
CCCCCTTCCAGCCACCAAACCCACGCCGGCGCCCCCTCCCCGTACAATTGGGGCGCTGGCATCCTGCCCGGCTCGCGCTGGGGTTGGGAG
GGGGCAGGCAGGAAGCGAGGGCCTGCGGGGTCTCTGCGTTTCCGGGGGAAACAGCCGGCCCTGCCCTGGGAGGGTCACAGTCCGCCCGCT
GCTGAAGGCGGCTCTGAGCTTTTCCGTCGCCACATCCCTCTCCCGCCCCTCAGTTCCCTGAGTGTGGCTTCTACGGCCTTTACGACAAGA
TCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGAGACATCCAGGAGGGCGACCTGGTGGAGG
TGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTGCACTCCTATCGGGCGCCTGCCTTCTGTG
ATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGGCTGAACTACCACAAGCGCTGTGCCTTCA
GCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGTGGCCACTCGGTGCGCCTCGGCACCTCCG
AGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGTCCCCCGTCATCCTCTTCCTCCTCTTCTG
CCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTGCCGCACACCTTCCTCATCCACAGCTATA
CACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTGCAATGCAAAGACTGCAAGTTTAACTGTC
ACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGATGTGCCGATGGAGGAGGCCACCGATTTCA
GCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCCCACTCAGAGAATGCGCTCCACGCCAGTG
AGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGGGTGGTGCAATCGGTGCGACACACGACGC
GGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTGAGAAAGCGGCACTATTGGCGCCTGGACT
GCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTGTCAGAAATCCTCACGGTGGAGTCCGCCC
AGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAATGCCACCTACTTCGTGGGCGAGATGCCTG
GCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCCATCCGCCAGGCCCTGATGCCCGTCATCC
TTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCTGTGTCCAACAGTCAGATCCAAGAGAATG
TGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGAGTGGTCTATGGAGGAAAACACCGGAAGA
CAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGCCAGCTCCGGAATGAAGTGGCCATTCTGC
AGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTGTTTGTGGTGATGGAGAAGCTGCATGGGG
ACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTCCTCATCACCCAGATCCTGGTGGCTTTGA
GACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCATCAGCAGACCCATTTCCTCAGGTGAAGC
TGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGCACGCCGGCCTACCTGGCACCCGAGGTGC
TGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTCAGCCTCAGCGGCACCTTCCCTTTCAACG
AGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGGAGCCACATCTCAGCTGGAGGACTACTGG
CTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTG
ATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAAC
TTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAG
GGCCTAAAGTCCAAAACCCAAAGATGTCAATACTGTGGGATCATCTGAATCTAAAAGGGCATTACCTAATTCTTCAGAAGAAAGGTCAGT
GCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGT

>68814_68814_1_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370546_length(amino acids)=811AA_BP=686
MLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS
IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYT
RPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASE
EEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQ
NFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENV
DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD
MLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL
LNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSD
PGQTKDLCSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQNPKMSILWDHLNLKGHYLILQKKGQC

--------------------------------------------------------------
>68814_68814_2_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370549_length(transcript)=3336nt_BP=2421nt
GTTCATTCAGCATCCCCTCCCACCTCCGCCAGGTTCCGGAAAATTCGAGGTGTCCACGCTCCCGGAGCCACTCTCCCTCCCACCCCAGCT
CCCCCTTCCAGCCACCAAACCCACGCCGGCGCCCCCTCCCCGTACAATTGGGGCGCTGGCATCCTGCCCGGCTCGCGCTGGGGTTGGGAG
GGGGCAGGCAGGAAGCGAGGGCCTGCGGGGTCTCTGCGTTTCCGGGGGAAACAGCCGGCCCTGCCCTGGGAGGGTCACAGTCCGCCCGCT
GCTGAAGGCGGCTCTGAGCTTTTCCGTCGCCACATCCCTCTCCCGCCCCTCAGTTCCCTGAGTGTGGCTTCTACGGCCTTTACGACAAGA
TCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGAGACATCCAGGAGGGCGACCTGGTGGAGG
TGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTGCACTCCTATCGGGCGCCTGCCTTCTGTG
ATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGGCTGAACTACCACAAGCGCTGTGCCTTCA
GCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGTGGCCACTCGGTGCGCCTCGGCACCTCCG
AGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGTCCCCCGTCATCCTCTTCCTCCTCTTCTG
CCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTGCCGCACACCTTCCTCATCCACAGCTATA
CACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTGCAATGCAAAGACTGCAAGTTTAACTGTC
ACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGATGTGCCGATGGAGGAGGCCACCGATTTCA
GCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCCCACTCAGAGAATGCGCTCCACGCCAGTG
AGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGGGTGGTGCAATCGGTGCGACACACGACGC
GGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTGAGAAAGCGGCACTATTGGCGCCTGGACT
GCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTGTCAGAAATCCTCACGGTGGAGTCCGCCC
AGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAATGCCACCTACTTCGTGGGCGAGATGCCTG
GCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCCATCCGCCAGGCCCTGATGCCCGTCATCC
TTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCTGTGTCCAACAGTCAGATCCAAGAGAATG
TGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGAGTGGTCTATGGAGGAAAACACCGGAAGA
CAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGCCAGCTCCGGAATGAAGTGGCCATTCTGC
AGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTGTTTGTGGTGATGGAGAAGCTGCATGGGG
ACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTCCTCATCACCCAGATCCTGGTGGCTTTGA
GACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCATCAGCAGACCCATTTCCTCAGGTGAAGC
TGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGCACGCCGGCCTACCTGGCACCCGAGGTGC
TGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTCAGCCTCAGCGGCACCTTCCCTTTCAACG
AGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGGAGCCACATCTCAGCTGGAGGACTACTGG
CTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTG
ATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAAC
TTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAG
GGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTT
CGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAA
GCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTTCCACTCCTCCACTCCAGTAGTATCCTCTGTTTTCAGACATCCTAG
CAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTTGCTCTCCAAAGAGACTAAATGTCATAGCGTGATCTTAGCCTAGGT
AGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCTATATAAGGATAAAGGCATGTGTATAGAGCAGAATGTTTCCCTTCA
TGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATGTTTCCAGACAACTCCCCATGATCCTGTCACACAGCATTATAACCA
CAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAGATGAGGAAGGAAAAAAACTGGGTGGACCTACAAAAACCCATCCTC

>68814_68814_2_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370549_length(amino acids)=860AA_BP=686
MLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS
IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYT
RPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASE
EEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQ
NFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENV
DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD
MLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL
LNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSD
PGQTKDLCSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPS

--------------------------------------------------------------
>68814_68814_3_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370552_length(transcript)=3336nt_BP=2421nt
GTTCATTCAGCATCCCCTCCCACCTCCGCCAGGTTCCGGAAAATTCGAGGTGTCCACGCTCCCGGAGCCACTCTCCCTCCCACCCCAGCT
CCCCCTTCCAGCCACCAAACCCACGCCGGCGCCCCCTCCCCGTACAATTGGGGCGCTGGCATCCTGCCCGGCTCGCGCTGGGGTTGGGAG
GGGGCAGGCAGGAAGCGAGGGCCTGCGGGGTCTCTGCGTTTCCGGGGGAAACAGCCGGCCCTGCCCTGGGAGGGTCACAGTCCGCCCGCT
GCTGAAGGCGGCTCTGAGCTTTTCCGTCGCCACATCCCTCTCCCGCCCCTCAGTTCCCTGAGTGTGGCTTCTACGGCCTTTACGACAAGA
TCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGAGACATCCAGGAGGGCGACCTGGTGGAGG
TGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTGCACTCCTATCGGGCGCCTGCCTTCTGTG
ATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGGCTGAACTACCACAAGCGCTGTGCCTTCA
GCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGTGGCCACTCGGTGCGCCTCGGCACCTCCG
AGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGTCCCCCGTCATCCTCTTCCTCCTCTTCTG
CCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTGCCGCACACCTTCCTCATCCACAGCTATA
CACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTGCAATGCAAAGACTGCAAGTTTAACTGTC
ACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGATGTGCCGATGGAGGAGGCCACCGATTTCA
GCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCCCACTCAGAGAATGCGCTCCACGCCAGTG
AGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGGGTGGTGCAATCGGTGCGACACACGACGC
GGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTGAGAAAGCGGCACTATTGGCGCCTGGACT
GCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTGTCAGAAATCCTCACGGTGGAGTCCGCCC
AGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAATGCCACCTACTTCGTGGGCGAGATGCCTG
GCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCCATCCGCCAGGCCCTGATGCCCGTCATCC
TTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCTGTGTCCAACAGTCAGATCCAAGAGAATG
TGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGAGTGGTCTATGGAGGAAAACACCGGAAGA
CAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGCCAGCTCCGGAATGAAGTGGCCATTCTGC
AGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTGTTTGTGGTGATGGAGAAGCTGCATGGGG
ACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTCCTCATCACCCAGATCCTGGTGGCTTTGA
GACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCATCAGCAGACCCATTTCCTCAGGTGAAGC
TGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGCACGCCGGCCTACCTGGCACCCGAGGTGC
TGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTCAGCCTCAGCGGCACCTTCCCTTTCAACG
AGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGGAGCCACATCTCAGCTGGAGGACTACTGG
CTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTG
ATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAAC
TTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAG
GGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTT
CGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAA
GCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTTCCACTCCTCCACTCCAGTAGTATCCTCTGTTTTCAGACATCCTAG
CAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTTGCTCTCCAAAGAGACTAAATGTCATAGCGTGATCTTAGCCTAGGT
AGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCTATATAAGGATAAAGGCATGTGTATAGAGCAGAATGTTTCCCTTCA
TGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATGTTTCCAGACAACTCCCCATGATCCTGTCACACAGCATTATAACCA
CAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAGATGAGGAAGGAAAAAAACTGGGTGGACCTACAAAAACCCATCCTC

>68814_68814_3_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000370552_length(amino acids)=860AA_BP=686
MLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS
IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYT
RPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASE
EEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQ
NFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENV
DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD
MLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL
LNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSD
PGQTKDLCSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPS

--------------------------------------------------------------
>68814_68814_4_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000404542_length(transcript)=2880nt_BP=2421nt
GTTCATTCAGCATCCCCTCCCACCTCCGCCAGGTTCCGGAAAATTCGAGGTGTCCACGCTCCCGGAGCCACTCTCCCTCCCACCCCAGCT
CCCCCTTCCAGCCACCAAACCCACGCCGGCGCCCCCTCCCCGTACAATTGGGGCGCTGGCATCCTGCCCGGCTCGCGCTGGGGTTGGGAG
GGGGCAGGCAGGAAGCGAGGGCCTGCGGGGTCTCTGCGTTTCCGGGGGAAACAGCCGGCCCTGCCCTGGGAGGGTCACAGTCCGCCCGCT
GCTGAAGGCGGCTCTGAGCTTTTCCGTCGCCACATCCCTCTCCCGCCCCTCAGTTCCCTGAGTGTGGCTTCTACGGCCTTTACGACAAGA
TCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGAGACATCCAGGAGGGCGACCTGGTGGAGG
TGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTGCACTCCTATCGGGCGCCTGCCTTCTGTG
ATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGGCTGAACTACCACAAGCGCTGTGCCTTCA
GCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGTGGCCACTCGGTGCGCCTCGGCACCTCCG
AGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGTCCCCCGTCATCCTCTTCCTCCTCTTCTG
CCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTGCCGCACACCTTCCTCATCCACAGCTATA
CACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTGCAATGCAAAGACTGCAAGTTTAACTGTC
ACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGATGTGCCGATGGAGGAGGCCACCGATTTCA
GCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCCCACTCAGAGAATGCGCTCCACGCCAGTG
AGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGGGTGGTGCAATCGGTGCGACACACGACGC
GGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTGAGAAAGCGGCACTATTGGCGCCTGGACT
GCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTGTCAGAAATCCTCACGGTGGAGTCCGCCC
AGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAATGCCACCTACTTCGTGGGCGAGATGCCTG
GCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCCATCCGCCAGGCCCTGATGCCCGTCATCC
TTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCTGTGTCCAACAGTCAGATCCAAGAGAATG
TGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGAGTGGTCTATGGAGGAAAACACCGGAAGA
CAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGCCAGCTCCGGAATGAAGTGGCCATTCTGC
AGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTGTTTGTGGTGATGGAGAAGCTGCATGGGG
ACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTCCTCATCACCCAGATCCTGGTGGCTTTGA
GACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCATCAGCAGACCCATTTCCTCAGGTGAAGC
TGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGCACGCCGGCCTACCTGGCACCCGAGGTGC
TGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTCAGCCTCAGCGGCACCTTCCCTTTCAACG
AGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGGAGCCACATCTCAGCTGGAGGACTACTGG
CTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTG
ATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAAC
TTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAG
GGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTT
CGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAA

>68814_68814_4_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000600194_HPSE2_chr10_100249953_ENST00000404542_length(amino acids)=839AA_BP=686
MLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS
IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYT
RPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASE
EEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQ
NFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENV
DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD
MLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL
LNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSD
PGQTKDLCSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPS

--------------------------------------------------------------
>68814_68814_5_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370546_length(transcript)=2888nt_BP=2359nt
GACTTAAACTTTGGAGGGGGAAAAAGAGCTACTGGCGCCTGGCGACCCTCCCTGCCCCCCACCCAACCCCGCTCCGGCAACGCCCCCTTC
CTCACGGCTCCCGACCGAACTTTTCTCCAACTTCTGCGACTCATCCCGGCCCCGGGTTCCGGGGTCTCCTTTCACATCCAGATCGGGCTG
ACCCGCGAGTTCGTGCTGTTGCCCGCCGCCTCCGAGCTGGCTCATGTGAAGCAGCTGGCCTGTTCCATCGTGGACCAGAAGTTCCCTGAG
TGTGGCTTCTACGGCCTTTACGACAAGATCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGA
GACATCCAGGAGGGCGACCTGGTGGAGGTGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTG
CACTCCTATCGGGCGCCTGCCTTCTGTGATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGG
CTGAACTACCACAAGCGCTGTGCCTTCAGCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGT
GGCCACTCGGTGCGCCTCGGCACCTCCGAGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGT
CCCCCGTCATCCTCTTCCTCCTCTTCTGCCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTG
CCGCACACCTTCCTCATCCACAGCTATACACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTG
CAATGCAAAGACTGCAAGTTTAACTGTCACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGAT
GTGCCGATGGAGGAGGCCACCGATTTCAGCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCC
CACTCAGAGAATGCGCTCCACGCCAGTGAGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGG
GTGGTGCAATCGGTGCGACACACGACGCGGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTG
AGAAAGCGGCACTATTGGCGCCTGGACTGCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTG
TCAGAAATCCTCACGGTGGAGTCCGCCCAGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAAT
GCCACCTACTTCGTGGGCGAGATGCCTGGCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCC
ATCCGCCAGGCCCTGATGCCCGTCATCCTTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCT
GTGTCCAACAGTCAGATCCAAGAGAATGTGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGA
GTGGTCTATGGAGGAAAACACCGGAAGACAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGC
CAGCTCCGGAATGAAGTGGCCATTCTGCAGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTG
TTTGTGGTGATGGAGAAGCTGCATGGGGACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTC
CTCATCACCCAGATCCTGGTGGCTTTGAGACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCA
TCAGCAGACCCATTTCCTCAGGTGAAGCTGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGC
ACGCCGGCCTACCTGGCACCCGAGGTGCTGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTC
AGCCTCAGCGGCACCTTCCCTTTCAACGAGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGG
AGCCACATCTCAGCTGGAGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCT
CCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCG
TGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCA
GTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAAACCCAAAGATGTCAATACTGTGGGATCATCTGAATCTAAAAGGGCAT
TACCTAATTCTTCAGAAGAAAGGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCC
GCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCT

>68814_68814_5_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370546_length(amino acids)=894AA_BP=769
MPPTQPRSGNAPFLTAPDRTFLQLLRLIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDP
TSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG
ARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQA
CKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGG
KAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPP
GTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQ
IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS
SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR
SLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSDPGQTKDL

--------------------------------------------------------------
>68814_68814_6_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370549_length(transcript)=3274nt_BP=2359nt
GACTTAAACTTTGGAGGGGGAAAAAGAGCTACTGGCGCCTGGCGACCCTCCCTGCCCCCCACCCAACCCCGCTCCGGCAACGCCCCCTTC
CTCACGGCTCCCGACCGAACTTTTCTCCAACTTCTGCGACTCATCCCGGCCCCGGGTTCCGGGGTCTCCTTTCACATCCAGATCGGGCTG
ACCCGCGAGTTCGTGCTGTTGCCCGCCGCCTCCGAGCTGGCTCATGTGAAGCAGCTGGCCTGTTCCATCGTGGACCAGAAGTTCCCTGAG
TGTGGCTTCTACGGCCTTTACGACAAGATCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGA
GACATCCAGGAGGGCGACCTGGTGGAGGTGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTG
CACTCCTATCGGGCGCCTGCCTTCTGTGATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGG
CTGAACTACCACAAGCGCTGTGCCTTCAGCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGT
GGCCACTCGGTGCGCCTCGGCACCTCCGAGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGT
CCCCCGTCATCCTCTTCCTCCTCTTCTGCCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTG
CCGCACACCTTCCTCATCCACAGCTATACACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTG
CAATGCAAAGACTGCAAGTTTAACTGTCACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGAT
GTGCCGATGGAGGAGGCCACCGATTTCAGCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCC
CACTCAGAGAATGCGCTCCACGCCAGTGAGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGG
GTGGTGCAATCGGTGCGACACACGACGCGGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTG
AGAAAGCGGCACTATTGGCGCCTGGACTGCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTG
TCAGAAATCCTCACGGTGGAGTCCGCCCAGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAAT
GCCACCTACTTCGTGGGCGAGATGCCTGGCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCC
ATCCGCCAGGCCCTGATGCCCGTCATCCTTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCT
GTGTCCAACAGTCAGATCCAAGAGAATGTGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGA
GTGGTCTATGGAGGAAAACACCGGAAGACAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGC
CAGCTCCGGAATGAAGTGGCCATTCTGCAGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTG
TTTGTGGTGATGGAGAAGCTGCATGGGGACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTC
CTCATCACCCAGATCCTGGTGGCTTTGAGACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCA
TCAGCAGACCCATTTCCTCAGGTGAAGCTGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGC
ACGCCGGCCTACCTGGCACCCGAGGTGCTGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTC
AGCCTCAGCGGCACCTTCCCTTTCAACGAGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGG
AGCCACATCTCAGCTGGAGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCT
CCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCG
TGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCA
GTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGAC
CCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGT
CAATGCTTTGGCCTGCCGCTACCGATAAGCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTTCCACTCCTCCACTCCAG
TAGTATCCTCTGTTTTCAGACATCCTAGCAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTTGCTCTCCAAAGAGACTA
AATGTCATAGCGTGATCTTAGCCTAGGTAGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCTATATAAGGATAAAGGCA
TGTGTATAGAGCAGAATGTTTCCCTTCATGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATGTTTCCAGACAACTCCCC
ATGATCCTGTCACACAGCATTATAACCACAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAGATGAGGAAGGAAAAAAA

>68814_68814_6_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370549_length(amino acids)=943AA_BP=769
MPPTQPRSGNAPFLTAPDRTFLQLLRLIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDP
TSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG
ARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQA
CKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGG
KAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPP
GTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQ
IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS
SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR
SLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSDPGQTKDL
CSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPSGRPDIGH

--------------------------------------------------------------
>68814_68814_7_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370552_length(transcript)=3274nt_BP=2359nt
GACTTAAACTTTGGAGGGGGAAAAAGAGCTACTGGCGCCTGGCGACCCTCCCTGCCCCCCACCCAACCCCGCTCCGGCAACGCCCCCTTC
CTCACGGCTCCCGACCGAACTTTTCTCCAACTTCTGCGACTCATCCCGGCCCCGGGTTCCGGGGTCTCCTTTCACATCCAGATCGGGCTG
ACCCGCGAGTTCGTGCTGTTGCCCGCCGCCTCCGAGCTGGCTCATGTGAAGCAGCTGGCCTGTTCCATCGTGGACCAGAAGTTCCCTGAG
TGTGGCTTCTACGGCCTTTACGACAAGATCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGA
GACATCCAGGAGGGCGACCTGGTGGAGGTGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTG
CACTCCTATCGGGCGCCTGCCTTCTGTGATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGG
CTGAACTACCACAAGCGCTGTGCCTTCAGCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGT
GGCCACTCGGTGCGCCTCGGCACCTCCGAGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGT
CCCCCGTCATCCTCTTCCTCCTCTTCTGCCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTG
CCGCACACCTTCCTCATCCACAGCTATACACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTG
CAATGCAAAGACTGCAAGTTTAACTGTCACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGAT
GTGCCGATGGAGGAGGCCACCGATTTCAGCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCC
CACTCAGAGAATGCGCTCCACGCCAGTGAGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGG
GTGGTGCAATCGGTGCGACACACGACGCGGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTG
AGAAAGCGGCACTATTGGCGCCTGGACTGCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTG
TCAGAAATCCTCACGGTGGAGTCCGCCCAGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAAT
GCCACCTACTTCGTGGGCGAGATGCCTGGCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCC
ATCCGCCAGGCCCTGATGCCCGTCATCCTTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCT
GTGTCCAACAGTCAGATCCAAGAGAATGTGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGA
GTGGTCTATGGAGGAAAACACCGGAAGACAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGC
CAGCTCCGGAATGAAGTGGCCATTCTGCAGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTG
TTTGTGGTGATGGAGAAGCTGCATGGGGACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTC
CTCATCACCCAGATCCTGGTGGCTTTGAGACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCA
TCAGCAGACCCATTTCCTCAGGTGAAGCTGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGC
ACGCCGGCCTACCTGGCACCCGAGGTGCTGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTC
AGCCTCAGCGGCACCTTCCCTTTCAACGAGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGG
AGCCACATCTCAGCTGGAGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCT
CCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCG
TGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCA
GTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGAC
CCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGT
CAATGCTTTGGCCTGCCGCTACCGATAAGCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTTCCACTCCTCCACTCCAG
TAGTATCCTCTGTTTTCAGACATCCTAGCAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTTGCTCTCCAAAGAGACTA
AATGTCATAGCGTGATCTTAGCCTAGGTAGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCTATATAAGGATAAAGGCA
TGTGTATAGAGCAGAATGTTTCCCTTCATGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATGTTTCCAGACAACTCCCC
ATGATCCTGTCACACAGCATTATAACCACAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAGATGAGGAAGGAAAAAAA

>68814_68814_7_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000370552_length(amino acids)=943AA_BP=769
MPPTQPRSGNAPFLTAPDRTFLQLLRLIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDP
TSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG
ARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQA
CKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGG
KAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPP
GTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQ
IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS
SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR
SLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSDPGQTKDL
CSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPSGRPDIGH

--------------------------------------------------------------
>68814_68814_8_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000404542_length(transcript)=2818nt_BP=2359nt
GACTTAAACTTTGGAGGGGGAAAAAGAGCTACTGGCGCCTGGCGACCCTCCCTGCCCCCCACCCAACCCCGCTCCGGCAACGCCCCCTTC
CTCACGGCTCCCGACCGAACTTTTCTCCAACTTCTGCGACTCATCCCGGCCCCGGGTTCCGGGGTCTCCTTTCACATCCAGATCGGGCTG
ACCCGCGAGTTCGTGCTGTTGCCCGCCGCCTCCGAGCTGGCTCATGTGAAGCAGCTGGCCTGTTCCATCGTGGACCAGAAGTTCCCTGAG
TGTGGCTTCTACGGCCTTTACGACAAGATCCTGCTTTTCAAACATGACCCCACGTCGGCCAACCTCCTGCAGCTGGTGCGCTCGTCCGGA
GACATCCAGGAGGGCGACCTGGTGGAGGTGGTGCTGTCGGCCTCGGCCACCTTCGAGGACTTCCAGATCCGCCCGCACGCCCTCACGGTG
CACTCCTATCGGGCGCCTGCCTTCTGTGATCACTGCGGGGAGATGCTCTTCGGCCTAGTGCGCCAGGGCCTCAAGTGCGATGGCTGCGGG
CTGAACTACCACAAGCGCTGTGCCTTCAGCATCCCCAACAACTGTAGTGGGGCCCGCAAACGGCGCCTGTCATCCACGTCTCTGGCCAGT
GGCCACTCGGTGCGCCTCGGCACCTCCGAGTCCCTGCCCTGCACGGCTGAAGAGCTGAGCCGTAGCACCACCGAACTCCTGCCTCGCCGT
CCCCCGTCATCCTCTTCCTCCTCTTCTGCCTCATCGTATACGGGCCGCCCCATTGAGCTGGACAAGATGCTGCTCTCCAAGGTCAAGGTG
CCGCACACCTTCCTCATCCACAGCTATACACGGCCCACCGTTTGCCAGGCTTGCAAGAAACTCCTCAAGGGCCTCTTCCGGCAGGGCCTG
CAATGCAAAGACTGCAAGTTTAACTGTCACAAACGCTGCGCCACCCGCGTCCCTAATGACTGCCTGGGGGAGGCCCTTATCAATGGAGAT
GTGCCGATGGAGGAGGCCACCGATTTCAGCGAGGCTGACAAGAGCGCCCTCATGGATGAGTCAGAGGACTCCGGTGTCATCCCTGGCTCC
CACTCAGAGAATGCGCTCCACGCCAGTGAGGAGGAGGAAGGCGAGGGAGGCAAGGCCCAGAGCTCCCTGGGGTACATCCCCCTAATGAGG
GTGGTGCAATCGGTGCGACACACGACGCGGAAATCCAGCACCACGCTGCGGGAGGGTTGGGTGGTTCATTACAGCAACAAGGACACGCTG
AGAAAGCGGCACTATTGGCGCCTGGACTGCAAGTGTATCACGCTCTTCCAGAACAACACGACCAACAGATACTATAAGGAAATTCCGCTG
TCAGAAATCCTCACGGTGGAGTCCGCCCAGAACTTCAGCCTTGTGCCGCCGGGCACCAACCCACACTGCTTTGAGATCGTCACTGCCAAT
GCCACCTACTTCGTGGGCGAGATGCCTGGCGGGACTCCGGGTGGGCCAAGTGGGCAGGGGGCTGAGGCCGCCCGGGGCTGGGAGACAGCC
ATCCGCCAGGCCCTGATGCCCGTCATCCTTCAGGACGCACCCAGCGCCCCAGGCCACGCGCCCCACAGACAAGCTTCTCTGAGCATCTCT
GTGTCCAACAGTCAGATCCAAGAGAATGTGGACATTGCCACTGTCTACCAGATCTTCCCTGACGAAGTGCTGGGCTCAGGGCAGTTTGGA
GTGGTCTATGGAGGAAAACACCGGAAGACAGGCCGGGACGTGGCAGTTAAGGTCATTGACAAACTGCGCTTCCCTACCAAGCAGGAGAGC
CAGCTCCGGAATGAAGTGGCCATTCTGCAGAGCCTGCGGCATCCCGGGATCGTGAACCTGGAGTGCATGTTCGAGACGCCTGAGAAAGTG
TTTGTGGTGATGGAGAAGCTGCATGGGGACATGTTGGAGATGATCCTGTCCAGTGAGAAGGGCCGGCTGCCTGAGCGCCTCACCAAGTTC
CTCATCACCCAGATCCTGGTGGCTTTGAGACACCTTCACTTCAAGAACATTGTCCACTGTGACTTGAAACCAGAAAACGTGTTGCTGGCA
TCAGCAGACCCATTTCCTCAGGTGAAGCTGTGTGACTTTGGCTTTGCTCGCATCATCGGCGAGAAGTCGTTCCGCCGCTCAGTGGTGGGC
ACGCCGGCCTACCTGGCACCCGAGGTGCTGCTCAACCAGGGCTACAACCGCTCGCTGGACATGTGGTCAGTGGGCGTGATCATGTACGTC
AGCCTCAGCGGCACCTTCCCTTTCAACGAGGATGAGGACATCAATGACCAGATCCAGAACGCCGCCTTCATGTACCCGGCCAGCCCCTGG
AGCCACATCTCAGCTGGAGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCT
CCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCG
TGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCA
GTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGAC
CCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGT

>68814_68814_8_PRKD2-HPSE2_PRKD2_chr19_47181653_ENST00000601806_HPSE2_chr10_100249953_ENST00000404542_length(amino acids)=922AA_BP=769
MPPTQPRSGNAPFLTAPDRTFLQLLRLIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDP
TSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG
ARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQA
CKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGG
KAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPP
GTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQ
IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS
SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR
SLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGGLLALSPLQAPDRPQSLGCACGWAPAEATAWPSDPGQTKDL
CSLHKPPQPQLRSWVHYTFYHQLASIKKENQAGWDSQRQAGSPVPAAALWAGGPKVQVSATEWPALSDGGRRDPPRIEAPPPSGRPDIGH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRKD2-HPSE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRKD2-HPSE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRKD2-HPSE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource