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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRKRA-AGPS (FusionGDB2 ID:68864)

Fusion Gene Summary for PRKRA-AGPS

Fusion gene summary

Fusion gene information	Fusion gene name: PRKRA-AGPS
	Fusion gene ID: 68864
		Hgene	Tgene
	Gene symbol	PRKRA	AGPS
	Gene ID	8575	8540
	Gene name	protein activator of interferon induced protein kinase EIF2AK2	alkylglycerone phosphate synthase
	Synonyms	DYT16\|HSD14\|PACT\|RAX	ADAP-S\|ADAS\|ADHAPS\|ADPS\|ALDHPSY\|RCDP3
	Cytomap	2q31.2	2q31.2
	Type of gene	protein-coding	protein-coding
	Description	interferon-inducible double-stranded RNA-dependent protein kinase activator APKR-associated protein XPKR-associating protein Xprotein activator of the interferon-induced protein kinaseprotein kinase, interferon-inducible double-stranded RNA-dependent	alkyldihydroxyacetonephosphate synthase, peroxisomalaging-associated gene 5 proteinaging-associated protein 5alkyl-DHAP synthase
	Modification date	20200322	20200313
	UniProtAcc	.	O00116
	Ensembl transtripts involved in fusion gene	ENST00000325748, ENST00000432031, ENST00000438687, ENST00000487082, ENST00000470200,	ENST00000409888, ENST00000264167,
Fusion gene scores	* DoF score	5 X 5 X 4=100	7 X 6 X 6=252
	# samples	5	7
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PRKRA [Title/Abstract] AND AGPS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRKRA(179300872)-AGPS(178305693), # samples:1
Anticipated loss of major functional domain due to fusion event.	PRKRA-AGPS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PRKRA-AGPS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PRKRA-AGPS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKRA	GO:0030422	production of siRNA involved in RNA interference	17452327
Hgene	PRKRA	GO:0031054	pre-miRNA processing	16424907\|23661684
Hgene	PRKRA	GO:0035196	production of miRNAs involved in gene silencing by miRNA	23661684
Tgene	AGPS	GO:0008610	lipid biosynthetic process	9553082

Fusion gene breakpoints across PRKRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AGPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-7670-01A	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+

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Fusion Gene ORF analysis for PRKRA-AGPS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000325748	ENST00000409888	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
5CDS-intron	ENST00000432031	ENST00000409888	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
5CDS-intron	ENST00000438687	ENST00000409888	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
5CDS-intron	ENST00000487082	ENST00000409888	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
Frame-shift	ENST00000438687	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
In-frame	ENST00000325748	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
In-frame	ENST00000432031	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
In-frame	ENST00000487082	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
intron-3CDS	ENST00000470200	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+
intron-intron	ENST00000470200	ENST00000409888	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325748	PRKRA	chr2	179300872	-	ENST00000264167	AGPS	chr2	178305693	+	7966	985	51	2324	757
ENST00000487082	PRKRA	chr2	179300872	-	ENST00000264167	AGPS	chr2	178305693	+	7903	922	75	2261	728
ENST00000432031	PRKRA	chr2	179300872	-	ENST00000264167	AGPS	chr2	178305693	+	8046	1065	314	2404	696

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325748	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+	0.000226748	0.9997732
ENST00000487082	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+	0.000283673	0.99971634
ENST00000432031	ENST00000264167	PRKRA	chr2	179300872	-	AGPS	chr2	178305693	+	0.000137985	0.99986196

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Fusion Genomic Features for PRKRA-AGPS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PRKRA	chr2	179300871	-	AGPS	chr2	178305692	+	1.62E-06	0.99999833
PRKRA	chr2	179300871	-	AGPS	chr2	178305692	+	1.62E-06	0.99999833

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKRA-AGPS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:179300872/chr2:178305693)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AGPS O00116
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269\|PubMed:8399344, ECO:0000269\|PubMed:9553082}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000325748

126_194

261

314.0

Domain

DRBM 2

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000325748

34_101

261

314.0

Domain

DRBM 1

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000432031

126_194

250

303.0

Domain

DRBM 2

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000432031

34_101

250

303.0

Domain

DRBM 1

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000487082

126_194

236

289.0

Domain

DRBM 2

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000487082

34_101

236

289.0

Domain

DRBM 1

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

234_240

212

659.0

Nucleotide binding

FAD

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

303_309

212

659.0

Nucleotide binding

FAD

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

316_319

212

659.0

Nucleotide binding

FAD

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

368_374

212

659.0

Nucleotide binding

FAD

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

615_617

212

659.0

Region

Important for enzyme activity

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

654_658

212

659.0

Region

Important for enzyme activity

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000325748

240_308

261

314.0

Domain

DRBM 3

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000432031

240_308

250

303.0

Domain

DRBM 3

Hgene

PRKRA

chr2:179300872

chr2:178305693

ENST00000487082

240_308

236

289.0

Domain

DRBM 3

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

2_8

212

659.0

Compositional bias

Note=Poly-Ala

Tgene

AGPS

chr2:179300872

chr2:178305693

ENST00000264167

202_384

212

659.0

Domain

FAD-binding PCMH-type

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Fusion Gene Sequence for PRKRA-AGPS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>68864_68864_1_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000325748_AGPS_chr2_178305693_ENST00000264167_length(transcript)=7966nt_BP=985nt
GCGAGGGGGCGTAGCCGGAGCTACGGCACCAAGGCTCCGCCCCCACCCTGCCTGCCCCCTCGCTGGAGCAACGCAAGCAGGAGGCGGGGG
AGTCGGAGGAGGTGGCGGCGCTGGAGCTCCTCCCGGGGACCAGCGACCCGGGGAGCGAGCACGTCGCTCCGCACCGCTCTTCCTCCAGCC
GCTGAGCCGTCCCTTCTCGCCATGTCCCAGAGCAGGCACCGCGCCGAGGCCCCGCCGCTGGAGCGCGAGGACAGTGGGACCTTCAGTTTG
GGGAAGATGATAACAGCTAAGCCAGGGAAAACACCGATTCAGGTATTACACGAATACGGCATGAAGACCAAGAACATCCCAGTTTATGAA
TGTGAAAGATCTGATGTGCAAATACACGTGCCCACTTTCACCTTCAGAGTAACCGTTGGTGACATAACCTGCACAGGTGAAGGTACAAGT
AAGAAGCTGGCGAAACATAGAGCTGCAGAGGCTGCCATAAACATTTTGAAAGCCAATGCAAGTATTTGCTTTGCAGTTCCTGACCCCTTA
ATGCCTGACCCTTCCAAGCAACCAAAGAACCAGCTTAATCCTATTGGTTCATTACAGGAATTGGCTATTCATCATGGCTGGAGACTTCCT
GAATATACCCTTTCCCAGGAGGGAGGACCTGCTCATAAGAGAGAATATACTACAATTTGCAGGCTAGAGTCATTTATGGAAACTGGAAAG
GGGGCATCAAAAAAGCAAGCCAAAAGGAATGCTGCTGAGAAATTTCTTGCCAAATTTAGTAATATTTCTCCAGAGAACCACATTTCTTTA
ACAAATGTAGTAGGACATTCTTTAGGATGTACTTGGCATTCCTTGAGGAATTCTCCTGGTGAAAAGATCAACTTACTGAAAAGAAGCCTC
CTTAGTATTCCAAATACAGATTACATCCAGCTGCTTAGTGAAATTGCCAAGGAACAAGGTTTTAATATAACATATTTGGATATAGCATGC
CATGATGATGTAGTTAAGATTGTGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGC
CTGATGTGTCCTGCAGATGAGACAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTG
ACAGCTCATGTAGAGGCTGGCATAACAGGACAAGAGTTGGAAAGACAGCTTAAAGAAAGTGGTTATTGTACAGGTCATGAACCAGATTCC
CTGGAGTTCAGTACTGTAGGAGGATGGGTATCTACTCGCGCATCAGGCATGAAGAAGAATATCTATGGCAATATCGAGGACCTGGTGGTT
CATATAAAAATGGTAACACCTAGAGGTATAATAGAAAAAAGCTGTCAAGGACCTCGTATGTCAACAGGCCCTGATATCCATCACTTCATC
ATGGGATCTGAAGGAACTCTTGGTGTAATAACAGAAGCTACAATAAAAATCAGACCAGTCCCTGAATACCAAAAGTATGGCTCAGTAGCT
TTCCCTAATTTTGAACAAGGAGTAGCCTGTTTAAGAGAAATTGCAAAACAGAGATGTGCTCCGGCATCTATTCGCCTCATGGACAACAAG
CAGTTTCAGTTTGGTCATGCTCTTAAACCTCAGGTTTCCTCTATTTTTACATCATTTTTGGACGGATTAAAAAAGTTTTATATTACAAAG
TTTAAAGGATTTGACCCAAATCAGCTAAGTGTAGCCACATTACTGTTTGAGGGGGATCGTGAGAAGGTTCTTCAACATGAAAAACAAGTG
TATGATATTGCTGCAAAATTTGGTGGGTTGGCAGCTGGAGAAGATAATGGACAGAGAGGTTATTTGCTGACCTATGTTATTGCATACATT
CGAGACTTGGCTTTGGAATACTATGTATTAGGAGAATCTTTTGAGACTTCTGCTCCTTGGGACAGGGTGGTAGATCTCTGTAGAAATGTA
AAAGAAAGAATAACAAGGGAATGCAAAGAGAAGGGTGTTCAGTTTGCTCCTTTTTCTACATGCAGGGTGACGCAGACTTACGATGCAGGT
GCTTGTATCTACTTCTATTTTGCCTTTAACTACAGGGGAATTAGTGACCCACTGACCGTATTTGAACAAACTGAGGCAGCTGCTAGAGAA
GAAATCCTTGCTAATGGAGGGAGCCTGTCACATCACCATGGAGTGGGCAAGTTACGGAAGCAATGGCTAAAGGAAAGTATCTCTGATGTC
GGCTTTGGGATGCTGAAGTCTGTCAAGGAATATGTGGACCCCAATAACATCTTTGGAAACAGAAACCTTTTATAAATCCATTAGTACCAT
TACAAAAAAATGTCAATTTTTTTTTTAAGTTTTCAACTGTGGTTATACTAGTAATCAAATATATCATGGACTATATTTTGGATACATTTG
TTTCTTTGGTTTAAAATAAGTTTGTTTTCATTCTGTAGTTTGTTTTGTTTCTACATCTATGGATTGACAGATAGTATTCCTAAATCTCTC
TCATTGTAGGTACATCATTTTACATTCAGCGGTTGTCATTTCAAATTTTAGTCAGGCAGCACAAAGCTGTCAATTATTCCAGAGGAAGCT
GCTGCCAGCTGTTTTGTATTGTTGCTTCCTCTTGGGGAACAAAGACAGATTTGGTATCATTGATTGCTCAGCTAGCCTCTTTTTAAAAGA
ACGTTTCTGGGAATCAGATGTCTAGGGAAGGATTCCACTGAGGAGTGATACACGTGTACATTGTTTAAGAGCATAGTCTAGTGTGAGTAG
GCCATTAAGGGGAAGGATATTCATGAAAGAATTTAGGCAACCTGTTATTTAGAAAGCCTTCACGTCTGTAAGGTGCTTGGCCTACTTTTT
TTTTTAAATTAGTATACATGCATAAAACCTTGTATCATCAATATACAAATTATTCTGTTAGGGGACATGTTTTTGTTCTCCATGTTTCTG
TTTCTATTGTGGTATGAGTTGTATTTGTATCACTGAGATAACCTATTGTTATATTCTAATTCATTGATAATATGTTTTGTAAGAAAAGCT
GACATCCTTCATTGCAAGTGAAGAACAGGTTTACCATGAAATGAATGCCTTTATTCAACTTAGAGTCCTAATGTTTCTGATTTCACATTC
TTGTTGCTGAAATGCAGAAGAAACAGCTACAGCAAGAGCAGAAGGAAAACTCTTAGACTTAATGTCTCCAATTGCAAGAATTGTTTCACT
AAAGAAACAGTCATCATTCAACTACTGAATTTGAAAGCCTCAGCAGTTTCAATGACAAAAATCATTTTTGATTTTTTAAAATTAATCCCA
ATGGCATGATAAATTTTCATATAAAAAGTAAAGTTTCAATTTAGTTTTTAATAATGGTTTAATGCCTTTTTTGAATAACTGGTTTAACCT
AATTTTTTTTAAATGTAATGTATTAATGCATATACCATAATCAAAAGTTTGAAATATCCTGTTTCTTAAATAATGAGAACATTAATCACA
TTTAGCAAGCATTTGTACATTCAAACCTGGATATTAAAGTGAAATGATTACTTTGAATCACTGTCTGCCAAGGTTCATGATTCACATTTT
GAGATGGATTCTTTTCTTAATGCAATACCTAACTTTTGATAATTTTTTAAAACTAATATTTGATCAGATAATGTAAGTCAAAATGCAGAC
GATCCTTTAAAAGGATGCATTGTCTGTGTATGTAGCAACAGCTCCAAAGTATTTTTGGGCAGTTTGATACCTTTTATATCTGAAGTAGCC
TTAACCAGAAAAATGGTAATTTAAAATTGACAAAATGATATTTTTAAGACTTCAAAATGATAAATAATTTTTAACTATTAAAATTGGCCT
CAAACTAATAAATCTGTAATTAAATTAGAATTAAATATCAGTTTAACAACAAAATGAAATATTTATTTTTTAGAAGCTGCCTCTCTTCAT
TGGTCATTTATTTTTAATTATAAAATTTCCAACAGATCTTTGCTTTAAGCCCTTGATATTTGACCTAGTTGGACACTTGATGAGGAAGTT
GCCTCTAGAATTATAAAAATCTCAGCTTTATAAAATGCATCTGTTCACGAAGGTAATTTCTTTAATTGGTGATCAAAATATAAAATTAAG
GTACTAATGTCTCACTGGAAGTATATATATATATATATATATATGTATGCATGTGTGTGTGTGTATATATATATATATATATATGTATAT
GTTTCTGAGTAATTTTTAAAAAATAAAACAGGTTAATAAGAAGATCCATTCCTTTGCATGTGATTGTTATAACATTCTTTCCCAGGGAGT
TCAATTTCAGCAACCTCAGAAATCCATACTTGATATTAGGAAACTGTAAATGTAACACCTGAAATTATTATGTTCACTATTCTACATGAA
CCTTATGGAAATTCATGATTTATGTCTTTGTTTTTCTTTTTCCAAGTATATGCAGGACTCCCCAACCTTGATTTTATAATGGTGACTGCA
TTTTGTAGGTGGAATCATTTCTACCGAAATCATTTTGAAACACAAGAATATTGATCAGTACTGTTTCACTCTGATTTAGTAAATCAGAAA
GCCTCCCCCTACCCCCAGCCCCCACTTTCACATACCTTCTGGGAGGTGCCTCAGTATAGACTTGGTATCTGTGAAGGACTGAGTTCATGA
ATATGCACAGAAGCACTTAAACCATGCCTCTTATTTCTATAATATCTGAAAATGGCTTCATAAAAGTTAAGTCAGGAGAACACTGTTTAC
ATGACACTTCTTAACTCATTTTTAATGTTTATTTTTAATTTCAAAAACTTGTTGCCTATTTGGTTTTCAGTACTGCATAACACTGACTTT
CTTAAATTAGTCATAGTTGCAATAATTTACTTAAATTTGGTAATGTCACATTTGGGTTGGGGTTTCAGTGGGAATAGTAACTTGCCGCTA
GTGAGAAATGGCATTGAATACTAAAGACTCAATATGAACAGGCTTTATAGACCCTTAGAGAAACTGTTGCCTTAATGTTTGGTGCAATTT
CTAGTAGTGCATAAGTGAATTTAGTCTTATGATAAGTAACTTTGAGCTGTTTTTAGCTTAGTAAGAATTGTGGAAACCACATGTTTATTG
TGCCCATCATTTTACACAAAGAAAAGAGGATTATATTATTTCTTCTAAGGAAGTAGGAGTTTTCTTCCTAAAAGTGCTTACATATTGTAG
TACTATTACTTAAAAGTTATTTATGAAGTTGGGAGCCTTCTAGTTTGCCTGTGTTGATGTATTTTGAAAACAAAATTGCAATAAAGGATG
AGCTTCCATCGGTGTGTATGGTATACCAGATACAGATGGTTGCAAGGAAACCTTTTCCCCCACTAGAATAGTCTATTAGTAACTGCTAAG
TCCTAGCTTGCATTTTTGAAAATGCCTTTCTGCATGTTAGCACCCAGACTTTCCTTTGTCATATTCCTTTATAGCTACAACTTAACTGTA
GCTTATCAGAGAAGCTCTGTAGTCCTACACTGAAGTGTGTTCCCTTGGCTGTTCATATGGGGCTGGGTTTGGTTGAACTTCCATTCTGTA
TAAATGCTAGAACACAGTTACTACAGATTGATTCACAAACTGCATGTGCTGGTGCTTGAGGCAGCCAAAATGGAATGCTGTGGAAAGCAT
ATCTATATCTTAAAAAACACTCAGACAGGAGTTAAGGACAGCTTTAATAATTTTTTTGTTTACCACTTAATCTTTATCAACTTTGATTTT
AGTTAGGGCTTAGCTCATGGTTGAAGAAAAGTGGAAAATAACAAGTGCCCATTTAGGTTTGAAGAATCCAGAATGTTTTACCTTTGACTT
TATGAGTTATAGAAGCTTGGCTTTGCTCTAGGCTTCATGTTCCCAAATGAGCCATCTGTCAGTATATTCACTTAATTCTTACTAATTTCA
GTTTCCTGTAAAGGAAACAACTTACATATTGATGCTTAAATCCAGAAAGTGTAAAAGGTTTTCTTAAACTGTTAAAATATAGTGTCTGAT
ATAAAGGATGTAAGTTACTCAGCTTTCTGCTCCCTAAGCCAAACAGTGTTTGTCTTCAGTGTGAAATTTAACTGTAAAAACTACTTGTAA
TGTCAAGAGATTATAGATCATATTATTAATAAAATGGACCTGGGTCTAATATTTTTTTTCTTCAAAGGGAGTGTGAAGCTGTTTATTCTT
TTATTTGCATATGAGTTTTTCTTTTAGTTTTAGTTTTTCATGTTCATATTTCCACTGATTTGAAAACACAAAATTTATTTTTATAATTTT
GTTGCTTGTAGCATAATCAAGTGCAAAATCAAGTGCAACCTACTTGTGACTAAATCTCTTTGGATTTATAGCTGAGGATATTGTTAGCTA
GGTTTTGTCAATCCCTAATCATTTTTTAAAATCAATGCTGTATTCCCAGGAGGCTTTGAGACTCCTATGAACCTGAAGCACTCCCTTTTG
AACCTTGGAAGATCCTCAAAGAGTGAGCACTCTTGTGCTCTTCTAATCATAATTAATTCCTTAACAAATCAGAGTAAGGACCACTGACAT
ATAGAACCCTCAAGCCAAAGAACCATCACAGAATTTAGTAACTTTAGTTCTGTGAACATGAAAAGATTTCTTTTTTGGTTTCCAAAGGAG
ATTATTTATTTTTCCACAAGGAAAAACATCTTGCAGAGACTCTGAATTCCAAATCTGAGTGAGAAAGAAAAGGAAAAAAATCTGTTTCAT
GGTGGATTTCTAAGCAACATATATACATGTTTTTAAGACAACCTTTTGTTGGCAGTGTTTTTCCTGAACACCATATGCACCCTAGGAAAC
ATGTTTTTCCTTTAATCTTGTTCACATATCAGAAAAGGACATGAAATGCTCATACTGGCATACAAGTTTCTATAAGTAGTTATTTTTTGA
GCTACTTATACTATATCCCCAAAAGCTCACAGTGCCTTGTTGGGATTTTTTTTTTCCATGAACTAGCCATTATTTTAAATGAGTGGGAGA
GGGTAAGTCTTTAGACAGAGGTCATTCAGCAGTTCAAGACTATTCCTCTTCAAGAACATGTCAGGAATTAAGCAGTTATATGTGGAAACA
CTGGTAATTCTTTCCACAGTGTTGTTTTGGATAATCTGTTCTAGTATATTTAACTAATTGTATGGTGGACCTGTACTCTGATACACATCG
AATCAGTCAATGGGATTTGTATGTGCTTTTCCTTCCTACATTTTCATTCCTACTGCCCCAACCTAGTAGCCCTAAGTTGTGGCTTGGTGG
GTTTGGCATTGAGCCTCAAGACACTCACTACATTCTTTCTGGATGTTTGCTCACAGGCTCCCTGAGGAGCAGAACCTGTGGAGCTGGGGA
GTGCGGGTGGTTTCTATTCCTAATATTGTGTGTCAGTCCTTTTTCGTGTGATGGTGCCTTCAGAATAACGAATATTTCTGTTCTGGACAA
TGATTAAATCTTATGAGAAATATATGTAGGTTATATTAATTCTTGTCCATTTTTGCTAAGCCTGTGAAATACTTTGGCTCTGATACAACT
TAACTTGAATAATATCTTATCCTGAGTCTTCCTCCAAGGCAGTACATATTCCTGCCAGGACTGTAGTAATCCTTTGGGAACTACATGTGA
GTAAGCACTTGTATGTAAGCCATTATACTGCTGTAACTAATGCATACAAACAATTCTTCTCTTTACATTTATAGTCTAAAAGGGGATATG
CAGTGGGAAGGAAAATTCCTGAGAGATTCCAGCATAGCTTTGTCAATTCCGACTGAGCCATACTGTTTTCCACAAGGGCTCAACACATAG
TCAGTATTCCGTGCTTTCAGTGTGTGTTCAGATTCTCCTCTTACTGGTTTTCTTAGACTGTATTGTTCTATAAGCAAATGCCCATGTGTG

>68864_68864_1_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000325748_AGPS_chr2_178305693_ENST00000264167_length(amino acids)=757AA_BP=311
MPPRWSNASRRRGSRRRWRRWSSSRGPATRGASTSLRTALPPAAEPSLLAMSQSRHRAEAPPLEREDSGTFSLGKMITAKPGKTPIQVLH
EYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGS
LQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRN
SPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIACHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTS
QMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQG
PRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFT
SFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETS
APWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHHGVGK

--------------------------------------------------------------
>68864_68864_2_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000432031_AGPS_chr2_178305693_ENST00000264167_length(transcript)=8046nt_BP=1065nt
GCGGGGCGGGCGGAGGTGACGCTCGGTCGGCGCGCCCGGGAAGGGATCGTCAGGTTTTCCCTGAGAGGCTGCGGCGCTGCTGCCAGCCCT
GTTCTGTTGAGAATCTCTCCTACCCGCATTCAAGTGCTCTCTCTAAAGACCTCGCTCACCCCGCCTGCTCCTGCGGAGTGACTGCCGCAG
CGGGGCCGGAAGACAGGTGCGCCCCAGCCTCGCCAGCTCTGGCCCTGGCCTCCGGGGAACTCGGCGCCTCCCTCGTCACCGTCGGTGGCG
GTTAAAACTGGCCTCTACGCTTCTGCTTCAATCTCCAATTTGGCATGCAAAGCACACCTTTTTGTGGTTTTTGCAGTTTGGGGAAGATGA
TAACAGCTAAGCCAGGGAAAACACCGATTCAGGTATTACACGAATACGGCATGAAGACCAAGAACATCCCAGTTTATGAATGTGAAAGAT
CTGATGTGCAAATACACGTGCCCACTTTCACCTTCAGAGTAACCGTTGGTGACATAACCTGCACAGGTGAAGGTACAAGTAAGAAGCTGG
CGAAACATAGAGCTGCAGAGGCTGCCATAAACATTTTGAAAGCCAATGCAAGTATTTGCTTTGCAGTTCCTGACCCCTTAATGCCTGACC
CTTCCAAGCAACCAAAGAACCAGCTTAATCCTATTGGTTCATTACAGGAATTGGCTATTCATCATGGCTGGAGACTTCCTGAATATACCC
TTTCCCAGGAGGGAGGACCTGCTCATAAGAGAGAATATACTACAATTTGCAGGCTAGAGTCATTTATGGAAACTGGAAAGGGGGCATCAA
AAAAGCAAGCCAAAAGGAATGCTGCTGAGAAATTTCTTGCCAAATTTAGTAATATTTCTCCAGAGAACCACATTTCTTTAACAAATGTAG
TAGGACATTCTTTAGGATGTACTTGGCATTCCTTGAGGAATTCTCCTGGTGAAAAGATCAACTTACTGAAAAGAAGCCTCCTTAGTATTC
CAAATACAGATTACATCCAGCTGCTTAGTGAAATTGCCAAGGAACAAGGTTTTAATATAACATATTTGGATATAGCATGCCATGATGATG
TAGTTAAGATTGTGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTC
CTGCAGATGAGACAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATG
TAGAGGCTGGCATAACAGGACAAGAGTTGGAAAGACAGCTTAAAGAAAGTGGTTATTGTACAGGTCATGAACCAGATTCCCTGGAGTTCA
GTACTGTAGGAGGATGGGTATCTACTCGCGCATCAGGCATGAAGAAGAATATCTATGGCAATATCGAGGACCTGGTGGTTCATATAAAAA
TGGTAACACCTAGAGGTATAATAGAAAAAAGCTGTCAAGGACCTCGTATGTCAACAGGCCCTGATATCCATCACTTCATCATGGGATCTG
AAGGAACTCTTGGTGTAATAACAGAAGCTACAATAAAAATCAGACCAGTCCCTGAATACCAAAAGTATGGCTCAGTAGCTTTCCCTAATT
TTGAACAAGGAGTAGCCTGTTTAAGAGAAATTGCAAAACAGAGATGTGCTCCGGCATCTATTCGCCTCATGGACAACAAGCAGTTTCAGT
TTGGTCATGCTCTTAAACCTCAGGTTTCCTCTATTTTTACATCATTTTTGGACGGATTAAAAAAGTTTTATATTACAAAGTTTAAAGGAT
TTGACCCAAATCAGCTAAGTGTAGCCACATTACTGTTTGAGGGGGATCGTGAGAAGGTTCTTCAACATGAAAAACAAGTGTATGATATTG
CTGCAAAATTTGGTGGGTTGGCAGCTGGAGAAGATAATGGACAGAGAGGTTATTTGCTGACCTATGTTATTGCATACATTCGAGACTTGG
CTTTGGAATACTATGTATTAGGAGAATCTTTTGAGACTTCTGCTCCTTGGGACAGGGTGGTAGATCTCTGTAGAAATGTAAAAGAAAGAA
TAACAAGGGAATGCAAAGAGAAGGGTGTTCAGTTTGCTCCTTTTTCTACATGCAGGGTGACGCAGACTTACGATGCAGGTGCTTGTATCT
ACTTCTATTTTGCCTTTAACTACAGGGGAATTAGTGACCCACTGACCGTATTTGAACAAACTGAGGCAGCTGCTAGAGAAGAAATCCTTG
CTAATGGAGGGAGCCTGTCACATCACCATGGAGTGGGCAAGTTACGGAAGCAATGGCTAAAGGAAAGTATCTCTGATGTCGGCTTTGGGA
TGCTGAAGTCTGTCAAGGAATATGTGGACCCCAATAACATCTTTGGAAACAGAAACCTTTTATAAATCCATTAGTACCATTACAAAAAAA
TGTCAATTTTTTTTTTAAGTTTTCAACTGTGGTTATACTAGTAATCAAATATATCATGGACTATATTTTGGATACATTTGTTTCTTTGGT
TTAAAATAAGTTTGTTTTCATTCTGTAGTTTGTTTTGTTTCTACATCTATGGATTGACAGATAGTATTCCTAAATCTCTCTCATTGTAGG
TACATCATTTTACATTCAGCGGTTGTCATTTCAAATTTTAGTCAGGCAGCACAAAGCTGTCAATTATTCCAGAGGAAGCTGCTGCCAGCT
GTTTTGTATTGTTGCTTCCTCTTGGGGAACAAAGACAGATTTGGTATCATTGATTGCTCAGCTAGCCTCTTTTTAAAAGAACGTTTCTGG
GAATCAGATGTCTAGGGAAGGATTCCACTGAGGAGTGATACACGTGTACATTGTTTAAGAGCATAGTCTAGTGTGAGTAGGCCATTAAGG
GGAAGGATATTCATGAAAGAATTTAGGCAACCTGTTATTTAGAAAGCCTTCACGTCTGTAAGGTGCTTGGCCTACTTTTTTTTTTAAATT
AGTATACATGCATAAAACCTTGTATCATCAATATACAAATTATTCTGTTAGGGGACATGTTTTTGTTCTCCATGTTTCTGTTTCTATTGT
GGTATGAGTTGTATTTGTATCACTGAGATAACCTATTGTTATATTCTAATTCATTGATAATATGTTTTGTAAGAAAAGCTGACATCCTTC
ATTGCAAGTGAAGAACAGGTTTACCATGAAATGAATGCCTTTATTCAACTTAGAGTCCTAATGTTTCTGATTTCACATTCTTGTTGCTGA
AATGCAGAAGAAACAGCTACAGCAAGAGCAGAAGGAAAACTCTTAGACTTAATGTCTCCAATTGCAAGAATTGTTTCACTAAAGAAACAG
TCATCATTCAACTACTGAATTTGAAAGCCTCAGCAGTTTCAATGACAAAAATCATTTTTGATTTTTTAAAATTAATCCCAATGGCATGAT
AAATTTTCATATAAAAAGTAAAGTTTCAATTTAGTTTTTAATAATGGTTTAATGCCTTTTTTGAATAACTGGTTTAACCTAATTTTTTTT
AAATGTAATGTATTAATGCATATACCATAATCAAAAGTTTGAAATATCCTGTTTCTTAAATAATGAGAACATTAATCACATTTAGCAAGC
ATTTGTACATTCAAACCTGGATATTAAAGTGAAATGATTACTTTGAATCACTGTCTGCCAAGGTTCATGATTCACATTTTGAGATGGATT
CTTTTCTTAATGCAATACCTAACTTTTGATAATTTTTTAAAACTAATATTTGATCAGATAATGTAAGTCAAAATGCAGACGATCCTTTAA
AAGGATGCATTGTCTGTGTATGTAGCAACAGCTCCAAAGTATTTTTGGGCAGTTTGATACCTTTTATATCTGAAGTAGCCTTAACCAGAA
AAATGGTAATTTAAAATTGACAAAATGATATTTTTAAGACTTCAAAATGATAAATAATTTTTAACTATTAAAATTGGCCTCAAACTAATA
AATCTGTAATTAAATTAGAATTAAATATCAGTTTAACAACAAAATGAAATATTTATTTTTTAGAAGCTGCCTCTCTTCATTGGTCATTTA
TTTTTAATTATAAAATTTCCAACAGATCTTTGCTTTAAGCCCTTGATATTTGACCTAGTTGGACACTTGATGAGGAAGTTGCCTCTAGAA
TTATAAAAATCTCAGCTTTATAAAATGCATCTGTTCACGAAGGTAATTTCTTTAATTGGTGATCAAAATATAAAATTAAGGTACTAATGT
CTCACTGGAAGTATATATATATATATATATATATGTATGCATGTGTGTGTGTGTATATATATATATATATATATGTATATGTTTCTGAGT
AATTTTTAAAAAATAAAACAGGTTAATAAGAAGATCCATTCCTTTGCATGTGATTGTTATAACATTCTTTCCCAGGGAGTTCAATTTCAG
CAACCTCAGAAATCCATACTTGATATTAGGAAACTGTAAATGTAACACCTGAAATTATTATGTTCACTATTCTACATGAACCTTATGGAA
ATTCATGATTTATGTCTTTGTTTTTCTTTTTCCAAGTATATGCAGGACTCCCCAACCTTGATTTTATAATGGTGACTGCATTTTGTAGGT
GGAATCATTTCTACCGAAATCATTTTGAAACACAAGAATATTGATCAGTACTGTTTCACTCTGATTTAGTAAATCAGAAAGCCTCCCCCT
ACCCCCAGCCCCCACTTTCACATACCTTCTGGGAGGTGCCTCAGTATAGACTTGGTATCTGTGAAGGACTGAGTTCATGAATATGCACAG
AAGCACTTAAACCATGCCTCTTATTTCTATAATATCTGAAAATGGCTTCATAAAAGTTAAGTCAGGAGAACACTGTTTACATGACACTTC
TTAACTCATTTTTAATGTTTATTTTTAATTTCAAAAACTTGTTGCCTATTTGGTTTTCAGTACTGCATAACACTGACTTTCTTAAATTAG
TCATAGTTGCAATAATTTACTTAAATTTGGTAATGTCACATTTGGGTTGGGGTTTCAGTGGGAATAGTAACTTGCCGCTAGTGAGAAATG
GCATTGAATACTAAAGACTCAATATGAACAGGCTTTATAGACCCTTAGAGAAACTGTTGCCTTAATGTTTGGTGCAATTTCTAGTAGTGC
ATAAGTGAATTTAGTCTTATGATAAGTAACTTTGAGCTGTTTTTAGCTTAGTAAGAATTGTGGAAACCACATGTTTATTGTGCCCATCAT
TTTACACAAAGAAAAGAGGATTATATTATTTCTTCTAAGGAAGTAGGAGTTTTCTTCCTAAAAGTGCTTACATATTGTAGTACTATTACT
TAAAAGTTATTTATGAAGTTGGGAGCCTTCTAGTTTGCCTGTGTTGATGTATTTTGAAAACAAAATTGCAATAAAGGATGAGCTTCCATC
GGTGTGTATGGTATACCAGATACAGATGGTTGCAAGGAAACCTTTTCCCCCACTAGAATAGTCTATTAGTAACTGCTAAGTCCTAGCTTG
CATTTTTGAAAATGCCTTTCTGCATGTTAGCACCCAGACTTTCCTTTGTCATATTCCTTTATAGCTACAACTTAACTGTAGCTTATCAGA
GAAGCTCTGTAGTCCTACACTGAAGTGTGTTCCCTTGGCTGTTCATATGGGGCTGGGTTTGGTTGAACTTCCATTCTGTATAAATGCTAG
AACACAGTTACTACAGATTGATTCACAAACTGCATGTGCTGGTGCTTGAGGCAGCCAAAATGGAATGCTGTGGAAAGCATATCTATATCT
TAAAAAACACTCAGACAGGAGTTAAGGACAGCTTTAATAATTTTTTTGTTTACCACTTAATCTTTATCAACTTTGATTTTAGTTAGGGCT
TAGCTCATGGTTGAAGAAAAGTGGAAAATAACAAGTGCCCATTTAGGTTTGAAGAATCCAGAATGTTTTACCTTTGACTTTATGAGTTAT
AGAAGCTTGGCTTTGCTCTAGGCTTCATGTTCCCAAATGAGCCATCTGTCAGTATATTCACTTAATTCTTACTAATTTCAGTTTCCTGTA
AAGGAAACAACTTACATATTGATGCTTAAATCCAGAAAGTGTAAAAGGTTTTCTTAAACTGTTAAAATATAGTGTCTGATATAAAGGATG
TAAGTTACTCAGCTTTCTGCTCCCTAAGCCAAACAGTGTTTGTCTTCAGTGTGAAATTTAACTGTAAAAACTACTTGTAATGTCAAGAGA
TTATAGATCATATTATTAATAAAATGGACCTGGGTCTAATATTTTTTTTCTTCAAAGGGAGTGTGAAGCTGTTTATTCTTTTATTTGCAT
ATGAGTTTTTCTTTTAGTTTTAGTTTTTCATGTTCATATTTCCACTGATTTGAAAACACAAAATTTATTTTTATAATTTTGTTGCTTGTA
GCATAATCAAGTGCAAAATCAAGTGCAACCTACTTGTGACTAAATCTCTTTGGATTTATAGCTGAGGATATTGTTAGCTAGGTTTTGTCA
ATCCCTAATCATTTTTTAAAATCAATGCTGTATTCCCAGGAGGCTTTGAGACTCCTATGAACCTGAAGCACTCCCTTTTGAACCTTGGAA
GATCCTCAAAGAGTGAGCACTCTTGTGCTCTTCTAATCATAATTAATTCCTTAACAAATCAGAGTAAGGACCACTGACATATAGAACCCT
CAAGCCAAAGAACCATCACAGAATTTAGTAACTTTAGTTCTGTGAACATGAAAAGATTTCTTTTTTGGTTTCCAAAGGAGATTATTTATT
TTTCCACAAGGAAAAACATCTTGCAGAGACTCTGAATTCCAAATCTGAGTGAGAAAGAAAAGGAAAAAAATCTGTTTCATGGTGGATTTC
TAAGCAACATATATACATGTTTTTAAGACAACCTTTTGTTGGCAGTGTTTTTCCTGAACACCATATGCACCCTAGGAAACATGTTTTTCC
TTTAATCTTGTTCACATATCAGAAAAGGACATGAAATGCTCATACTGGCATACAAGTTTCTATAAGTAGTTATTTTTTGAGCTACTTATA
CTATATCCCCAAAAGCTCACAGTGCCTTGTTGGGATTTTTTTTTTCCATGAACTAGCCATTATTTTAAATGAGTGGGAGAGGGTAAGTCT
TTAGACAGAGGTCATTCAGCAGTTCAAGACTATTCCTCTTCAAGAACATGTCAGGAATTAAGCAGTTATATGTGGAAACACTGGTAATTC
TTTCCACAGTGTTGTTTTGGATAATCTGTTCTAGTATATTTAACTAATTGTATGGTGGACCTGTACTCTGATACACATCGAATCAGTCAA
TGGGATTTGTATGTGCTTTTCCTTCCTACATTTTCATTCCTACTGCCCCAACCTAGTAGCCCTAAGTTGTGGCTTGGTGGGTTTGGCATT
GAGCCTCAAGACACTCACTACATTCTTTCTGGATGTTTGCTCACAGGCTCCCTGAGGAGCAGAACCTGTGGAGCTGGGGAGTGCGGGTGG
TTTCTATTCCTAATATTGTGTGTCAGTCCTTTTTCGTGTGATGGTGCCTTCAGAATAACGAATATTTCTGTTCTGGACAATGATTAAATC
TTATGAGAAATATATGTAGGTTATATTAATTCTTGTCCATTTTTGCTAAGCCTGTGAAATACTTTGGCTCTGATACAACTTAACTTGAAT
AATATCTTATCCTGAGTCTTCCTCCAAGGCAGTACATATTCCTGCCAGGACTGTAGTAATCCTTTGGGAACTACATGTGAGTAAGCACTT
GTATGTAAGCCATTATACTGCTGTAACTAATGCATACAAACAATTCTTCTCTTTACATTTATAGTCTAAAAGGGGATATGCAGTGGGAAG
GAAAATTCCTGAGAGATTCCAGCATAGCTTTGTCAATTCCGACTGAGCCATACTGTTTTCCACAAGGGCTCAACACATAGTCAGTATTCC
GTGCTTTCAGTGTGTGTTCAGATTCTCCTCTTACTGGTTTTCTTAGACTGTATTGTTCTATAAGCAAATGCCCATGTGTGATTTTTAAGA

>68864_68864_2_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000432031_AGPS_chr2_178305693_ENST00000264167_length(amino acids)=696AA_BP=250
MQSTPFCGFCSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKA
NASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAK
FSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIACHDDVVKIVNLACKYNLCI
IPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMK
KNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQR
CAPASIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQ
RGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFAFNYRGISDPL

--------------------------------------------------------------
>68864_68864_3_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000487082_AGPS_chr2_178305693_ENST00000264167_length(transcript)=7903nt_BP=922nt
GCGGCGCGCGGGGCGGGCGGAGGTGACGCTCGGTCGGCGCGCCCGGGAAGGGATCGTCAGGTTTTCCCTGAGAGGCTGCGGCGCTGCTGC
CAGCCCTGTTCTGTTGAGAATCTCTCCTACCCGCATTCAAGTGCTCTCTCTAAAGACCTCGCTCACCCCGCCTGCTCCTGCGGAGTGACT
GCCGCAGCGGGGCCGGAAGACAGTTTGGGGAAGATGATAACAGCTAAGCCAGGGAAAACACCGATTCAGGTATTACACGAATACGGCATG
AAGACCAAGAACATCCCAGTTTATGAATGTGAAAGATCTGATGTGCAAATACACGTGCCCACTTTCACCTTCAGAGTAACCGTTGGTGAC
ATAACCTGCACAGGTGAAGGTACAAGTAAGAAGCTGGCGAAACATAGAGCTGCAGAGGCTGCCATAAACATTTTGAAAGCCAATGCAAGT
ATTTGCTTTGCAGTTCCTGACCCCTTAATGCCTGACCCTTCCAAGCAACCAAAGAACCAGCTTAATCCTATTGGTTCATTACAGGAATTG
GCTATTCATCATGGCTGGAGACTTCCTGAATATACCCTTTCCCAGGAGGGAGGACCTGCTCATAAGAGAGAATATACTACAATTTGCAGG
CTAGAGTCATTTATGGAAACTGGAAAGGGGGCATCAAAAAAGCAAGCCAAAAGGAATGCTGCTGAGAAATTTCTTGCCAAATTTAGTAAT
ATTTCTCCAGAGAACCACATTTCTTTAACAAATGTAGTAGGACATTCTTTAGGATGTACTTGGCATTCCTTGAGGAATTCTCCTGGTGAA
AAGATCAACTTACTGAAAAGAAGCCTCCTTAGTATTCCAAATACAGATTACATCCAGCTGCTTAGTGAAATTGCCAAGGAACAAGGTTTT
AATATAACATATTTGGATATAGCATGCCATGATGATGTAGTTAAGATTGTGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATT
GGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGACAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGA
ATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCATAACAGGACAAGAGTTGGAAAGACAGCTTAAAGAAAGTGGT
TATTGTACAGGTCATGAACCAGATTCCCTGGAGTTCAGTACTGTAGGAGGATGGGTATCTACTCGCGCATCAGGCATGAAGAAGAATATC
TATGGCAATATCGAGGACCTGGTGGTTCATATAAAAATGGTAACACCTAGAGGTATAATAGAAAAAAGCTGTCAAGGACCTCGTATGTCA
ACAGGCCCTGATATCCATCACTTCATCATGGGATCTGAAGGAACTCTTGGTGTAATAACAGAAGCTACAATAAAAATCAGACCAGTCCCT
GAATACCAAAAGTATGGCTCAGTAGCTTTCCCTAATTTTGAACAAGGAGTAGCCTGTTTAAGAGAAATTGCAAAACAGAGATGTGCTCCG
GCATCTATTCGCCTCATGGACAACAAGCAGTTTCAGTTTGGTCATGCTCTTAAACCTCAGGTTTCCTCTATTTTTACATCATTTTTGGAC
GGATTAAAAAAGTTTTATATTACAAAGTTTAAAGGATTTGACCCAAATCAGCTAAGTGTAGCCACATTACTGTTTGAGGGGGATCGTGAG
AAGGTTCTTCAACATGAAAAACAAGTGTATGATATTGCTGCAAAATTTGGTGGGTTGGCAGCTGGAGAAGATAATGGACAGAGAGGTTAT
TTGCTGACCTATGTTATTGCATACATTCGAGACTTGGCTTTGGAATACTATGTATTAGGAGAATCTTTTGAGACTTCTGCTCCTTGGGAC
AGGGTGGTAGATCTCTGTAGAAATGTAAAAGAAAGAATAACAAGGGAATGCAAAGAGAAGGGTGTTCAGTTTGCTCCTTTTTCTACATGC
AGGGTGACGCAGACTTACGATGCAGGTGCTTGTATCTACTTCTATTTTGCCTTTAACTACAGGGGAATTAGTGACCCACTGACCGTATTT
GAACAAACTGAGGCAGCTGCTAGAGAAGAAATCCTTGCTAATGGAGGGAGCCTGTCACATCACCATGGAGTGGGCAAGTTACGGAAGCAA
TGGCTAAAGGAAAGTATCTCTGATGTCGGCTTTGGGATGCTGAAGTCTGTCAAGGAATATGTGGACCCCAATAACATCTTTGGAAACAGA
AACCTTTTATAAATCCATTAGTACCATTACAAAAAAATGTCAATTTTTTTTTTAAGTTTTCAACTGTGGTTATACTAGTAATCAAATATA
TCATGGACTATATTTTGGATACATTTGTTTCTTTGGTTTAAAATAAGTTTGTTTTCATTCTGTAGTTTGTTTTGTTTCTACATCTATGGA
TTGACAGATAGTATTCCTAAATCTCTCTCATTGTAGGTACATCATTTTACATTCAGCGGTTGTCATTTCAAATTTTAGTCAGGCAGCACA
AAGCTGTCAATTATTCCAGAGGAAGCTGCTGCCAGCTGTTTTGTATTGTTGCTTCCTCTTGGGGAACAAAGACAGATTTGGTATCATTGA
TTGCTCAGCTAGCCTCTTTTTAAAAGAACGTTTCTGGGAATCAGATGTCTAGGGAAGGATTCCACTGAGGAGTGATACACGTGTACATTG
TTTAAGAGCATAGTCTAGTGTGAGTAGGCCATTAAGGGGAAGGATATTCATGAAAGAATTTAGGCAACCTGTTATTTAGAAAGCCTTCAC
GTCTGTAAGGTGCTTGGCCTACTTTTTTTTTTAAATTAGTATACATGCATAAAACCTTGTATCATCAATATACAAATTATTCTGTTAGGG
GACATGTTTTTGTTCTCCATGTTTCTGTTTCTATTGTGGTATGAGTTGTATTTGTATCACTGAGATAACCTATTGTTATATTCTAATTCA
TTGATAATATGTTTTGTAAGAAAAGCTGACATCCTTCATTGCAAGTGAAGAACAGGTTTACCATGAAATGAATGCCTTTATTCAACTTAG
AGTCCTAATGTTTCTGATTTCACATTCTTGTTGCTGAAATGCAGAAGAAACAGCTACAGCAAGAGCAGAAGGAAAACTCTTAGACTTAAT
GTCTCCAATTGCAAGAATTGTTTCACTAAAGAAACAGTCATCATTCAACTACTGAATTTGAAAGCCTCAGCAGTTTCAATGACAAAAATC
ATTTTTGATTTTTTAAAATTAATCCCAATGGCATGATAAATTTTCATATAAAAAGTAAAGTTTCAATTTAGTTTTTAATAATGGTTTAAT
GCCTTTTTTGAATAACTGGTTTAACCTAATTTTTTTTAAATGTAATGTATTAATGCATATACCATAATCAAAAGTTTGAAATATCCTGTT
TCTTAAATAATGAGAACATTAATCACATTTAGCAAGCATTTGTACATTCAAACCTGGATATTAAAGTGAAATGATTACTTTGAATCACTG
TCTGCCAAGGTTCATGATTCACATTTTGAGATGGATTCTTTTCTTAATGCAATACCTAACTTTTGATAATTTTTTAAAACTAATATTTGA
TCAGATAATGTAAGTCAAAATGCAGACGATCCTTTAAAAGGATGCATTGTCTGTGTATGTAGCAACAGCTCCAAAGTATTTTTGGGCAGT
TTGATACCTTTTATATCTGAAGTAGCCTTAACCAGAAAAATGGTAATTTAAAATTGACAAAATGATATTTTTAAGACTTCAAAATGATAA
ATAATTTTTAACTATTAAAATTGGCCTCAAACTAATAAATCTGTAATTAAATTAGAATTAAATATCAGTTTAACAACAAAATGAAATATT
TATTTTTTAGAAGCTGCCTCTCTTCATTGGTCATTTATTTTTAATTATAAAATTTCCAACAGATCTTTGCTTTAAGCCCTTGATATTTGA
CCTAGTTGGACACTTGATGAGGAAGTTGCCTCTAGAATTATAAAAATCTCAGCTTTATAAAATGCATCTGTTCACGAAGGTAATTTCTTT
AATTGGTGATCAAAATATAAAATTAAGGTACTAATGTCTCACTGGAAGTATATATATATATATATATATATGTATGCATGTGTGTGTGTG
TATATATATATATATATATATGTATATGTTTCTGAGTAATTTTTAAAAAATAAAACAGGTTAATAAGAAGATCCATTCCTTTGCATGTGA
TTGTTATAACATTCTTTCCCAGGGAGTTCAATTTCAGCAACCTCAGAAATCCATACTTGATATTAGGAAACTGTAAATGTAACACCTGAA
ATTATTATGTTCACTATTCTACATGAACCTTATGGAAATTCATGATTTATGTCTTTGTTTTTCTTTTTCCAAGTATATGCAGGACTCCCC
AACCTTGATTTTATAATGGTGACTGCATTTTGTAGGTGGAATCATTTCTACCGAAATCATTTTGAAACACAAGAATATTGATCAGTACTG
TTTCACTCTGATTTAGTAAATCAGAAAGCCTCCCCCTACCCCCAGCCCCCACTTTCACATACCTTCTGGGAGGTGCCTCAGTATAGACTT
GGTATCTGTGAAGGACTGAGTTCATGAATATGCACAGAAGCACTTAAACCATGCCTCTTATTTCTATAATATCTGAAAATGGCTTCATAA
AAGTTAAGTCAGGAGAACACTGTTTACATGACACTTCTTAACTCATTTTTAATGTTTATTTTTAATTTCAAAAACTTGTTGCCTATTTGG
TTTTCAGTACTGCATAACACTGACTTTCTTAAATTAGTCATAGTTGCAATAATTTACTTAAATTTGGTAATGTCACATTTGGGTTGGGGT
TTCAGTGGGAATAGTAACTTGCCGCTAGTGAGAAATGGCATTGAATACTAAAGACTCAATATGAACAGGCTTTATAGACCCTTAGAGAAA
CTGTTGCCTTAATGTTTGGTGCAATTTCTAGTAGTGCATAAGTGAATTTAGTCTTATGATAAGTAACTTTGAGCTGTTTTTAGCTTAGTA
AGAATTGTGGAAACCACATGTTTATTGTGCCCATCATTTTACACAAAGAAAAGAGGATTATATTATTTCTTCTAAGGAAGTAGGAGTTTT
CTTCCTAAAAGTGCTTACATATTGTAGTACTATTACTTAAAAGTTATTTATGAAGTTGGGAGCCTTCTAGTTTGCCTGTGTTGATGTATT
TTGAAAACAAAATTGCAATAAAGGATGAGCTTCCATCGGTGTGTATGGTATACCAGATACAGATGGTTGCAAGGAAACCTTTTCCCCCAC
TAGAATAGTCTATTAGTAACTGCTAAGTCCTAGCTTGCATTTTTGAAAATGCCTTTCTGCATGTTAGCACCCAGACTTTCCTTTGTCATA
TTCCTTTATAGCTACAACTTAACTGTAGCTTATCAGAGAAGCTCTGTAGTCCTACACTGAAGTGTGTTCCCTTGGCTGTTCATATGGGGC
TGGGTTTGGTTGAACTTCCATTCTGTATAAATGCTAGAACACAGTTACTACAGATTGATTCACAAACTGCATGTGCTGGTGCTTGAGGCA
GCCAAAATGGAATGCTGTGGAAAGCATATCTATATCTTAAAAAACACTCAGACAGGAGTTAAGGACAGCTTTAATAATTTTTTTGTTTAC
CACTTAATCTTTATCAACTTTGATTTTAGTTAGGGCTTAGCTCATGGTTGAAGAAAAGTGGAAAATAACAAGTGCCCATTTAGGTTTGAA
GAATCCAGAATGTTTTACCTTTGACTTTATGAGTTATAGAAGCTTGGCTTTGCTCTAGGCTTCATGTTCCCAAATGAGCCATCTGTCAGT
ATATTCACTTAATTCTTACTAATTTCAGTTTCCTGTAAAGGAAACAACTTACATATTGATGCTTAAATCCAGAAAGTGTAAAAGGTTTTC
TTAAACTGTTAAAATATAGTGTCTGATATAAAGGATGTAAGTTACTCAGCTTTCTGCTCCCTAAGCCAAACAGTGTTTGTCTTCAGTGTG
AAATTTAACTGTAAAAACTACTTGTAATGTCAAGAGATTATAGATCATATTATTAATAAAATGGACCTGGGTCTAATATTTTTTTTCTTC
AAAGGGAGTGTGAAGCTGTTTATTCTTTTATTTGCATATGAGTTTTTCTTTTAGTTTTAGTTTTTCATGTTCATATTTCCACTGATTTGA
AAACACAAAATTTATTTTTATAATTTTGTTGCTTGTAGCATAATCAAGTGCAAAATCAAGTGCAACCTACTTGTGACTAAATCTCTTTGG
ATTTATAGCTGAGGATATTGTTAGCTAGGTTTTGTCAATCCCTAATCATTTTTTAAAATCAATGCTGTATTCCCAGGAGGCTTTGAGACT
CCTATGAACCTGAAGCACTCCCTTTTGAACCTTGGAAGATCCTCAAAGAGTGAGCACTCTTGTGCTCTTCTAATCATAATTAATTCCTTA
ACAAATCAGAGTAAGGACCACTGACATATAGAACCCTCAAGCCAAAGAACCATCACAGAATTTAGTAACTTTAGTTCTGTGAACATGAAA
AGATTTCTTTTTTGGTTTCCAAAGGAGATTATTTATTTTTCCACAAGGAAAAACATCTTGCAGAGACTCTGAATTCCAAATCTGAGTGAG
AAAGAAAAGGAAAAAAATCTGTTTCATGGTGGATTTCTAAGCAACATATATACATGTTTTTAAGACAACCTTTTGTTGGCAGTGTTTTTC
CTGAACACCATATGCACCCTAGGAAACATGTTTTTCCTTTAATCTTGTTCACATATCAGAAAAGGACATGAAATGCTCATACTGGCATAC
AAGTTTCTATAAGTAGTTATTTTTTGAGCTACTTATACTATATCCCCAAAAGCTCACAGTGCCTTGTTGGGATTTTTTTTTTCCATGAAC
TAGCCATTATTTTAAATGAGTGGGAGAGGGTAAGTCTTTAGACAGAGGTCATTCAGCAGTTCAAGACTATTCCTCTTCAAGAACATGTCA
GGAATTAAGCAGTTATATGTGGAAACACTGGTAATTCTTTCCACAGTGTTGTTTTGGATAATCTGTTCTAGTATATTTAACTAATTGTAT
GGTGGACCTGTACTCTGATACACATCGAATCAGTCAATGGGATTTGTATGTGCTTTTCCTTCCTACATTTTCATTCCTACTGCCCCAACC
TAGTAGCCCTAAGTTGTGGCTTGGTGGGTTTGGCATTGAGCCTCAAGACACTCACTACATTCTTTCTGGATGTTTGCTCACAGGCTCCCT
GAGGAGCAGAACCTGTGGAGCTGGGGAGTGCGGGTGGTTTCTATTCCTAATATTGTGTGTCAGTCCTTTTTCGTGTGATGGTGCCTTCAG
AATAACGAATATTTCTGTTCTGGACAATGATTAAATCTTATGAGAAATATATGTAGGTTATATTAATTCTTGTCCATTTTTGCTAAGCCT
GTGAAATACTTTGGCTCTGATACAACTTAACTTGAATAATATCTTATCCTGAGTCTTCCTCCAAGGCAGTACATATTCCTGCCAGGACTG
TAGTAATCCTTTGGGAACTACATGTGAGTAAGCACTTGTATGTAAGCCATTATACTGCTGTAACTAATGCATACAAACAATTCTTCTCTT
TACATTTATAGTCTAAAAGGGGATATGCAGTGGGAAGGAAAATTCCTGAGAGATTCCAGCATAGCTTTGTCAATTCCGACTGAGCCATAC
TGTTTTCCACAAGGGCTCAACACATAGTCAGTATTCCGTGCTTTCAGTGTGTGTTCAGATTCTCCTCTTACTGGTTTTCTTAGACTGTAT

>68864_68864_3_PRKRA-AGPS_PRKRA_chr2_179300872_ENST00000487082_AGPS_chr2_178305693_ENST00000264167_length(amino acids)=728AA_BP=282
MRRCCQPCSVENLSYPHSSALSKDLAHPACSCGVTAAAGPEDSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFR
VTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREY
TTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIA
KEQGFNITYLDIACHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQ
LKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIK
IRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLF
EGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFA
PFSTCRVTQTYDAGACIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRKRA-AGPS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PRKRA-AGPS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PRKRA-AGPS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source