FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRMT1-PTOV1 (FusionGDB2 ID:68914)

Fusion Gene Summary for PRMT1-PTOV1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT1-PTOV1
Fusion gene ID: 68914
HgeneTgene
Gene symbol

PRMT1

PTOV1

Gene ID

3276

53635

Gene nameprotein arginine methyltransferase 1PTOV1 extended AT-hook containing adaptor protein
SynonymsANM1|HCP1|HRMT1L2|IR1B4ACID2|PTOV-1
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 1HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2histone-arginine N-methyltransferase PRMT1interferon receptor 1-bound protein 4prostate tumor-overexpressed gene 1 proteinactivator interaction domain-containing protein 2prostate tumor overexpressed 1
Modification date2020032920200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000391851, ENST00000454376, 
ENST00000532489, ENST00000527866, 
ENST00000391842, ENST00000598325, 
ENST00000599732, ENST00000601675, 
ENST00000221557, ENST00000600603, 
ENST00000601638, 
Fusion gene scores* DoF score4 X 4 X 3=488 X 8 X 5=320
# samples 610
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT1 [Title/Abstract] AND PTOV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRMT1(50183845)-PTOV1(50361806), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT1

GO:0016571

histone methylation

19405910

HgenePRMT1

GO:0018216

peptidyl-arginine methylation

18657504|19460357|26575292

HgenePRMT1

GO:0043985

histone H4-R3 methylation

11448779

HgenePRMT1

GO:0045652

regulation of megakaryocyte differentiation

26575292

HgenePRMT1

GO:0045653

negative regulation of megakaryocyte differentiation

20442406

HgenePRMT1

GO:0051260

protein homooligomerization

26876602


check buttonFusion gene breakpoints across PRMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTOV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1120-01APRMT1chr19

50183845

+PTOV1chr19

50361806

+


Top

Fusion Gene ORF analysis for PRMT1-PTOV1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000391851ENST00000391842PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000391851ENST00000598325PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000391851ENST00000599732PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000391851ENST00000601675PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000454376ENST00000391842PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000454376ENST00000598325PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000454376ENST00000599732PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000454376ENST00000601675PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000532489ENST00000391842PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000532489ENST00000598325PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000532489ENST00000599732PRMT1chr19

50183845

+PTOV1chr19

50361806

+
5CDS-3UTRENST00000532489ENST00000601675PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000391851ENST00000221557PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000391851ENST00000600603PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000391851ENST00000601638PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000454376ENST00000221557PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000454376ENST00000600603PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000454376ENST00000601638PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000532489ENST00000221557PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000532489ENST00000600603PRMT1chr19

50183845

+PTOV1chr19

50361806

+
In-frameENST00000532489ENST00000601638PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3CDSENST00000527866ENST00000221557PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3CDSENST00000527866ENST00000600603PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3CDSENST00000527866ENST00000601638PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3UTRENST00000527866ENST00000391842PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3UTRENST00000527866ENST00000598325PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3UTRENST00000527866ENST00000599732PRMT1chr19

50183845

+PTOV1chr19

50361806

+
intron-3UTRENST00000527866ENST00000601675PRMT1chr19

50183845

+PTOV1chr19

50361806

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532489PRMT1chr1950183845+ENST00000600603PTOV1chr1950361806+1036560440844134
ENST00000532489PRMT1chr1950183845+ENST00000601638PTOV1chr1950361806+1080560440874144
ENST00000532489PRMT1chr1950183845+ENST00000221557PTOV1chr1950361806+12595608411257139
ENST00000391851PRMT1chr1950183845+ENST00000600603PTOV1chr1950361806+743267129551140
ENST00000391851PRMT1chr1950183845+ENST00000601638PTOV1chr1950361806+787267129581150
ENST00000391851PRMT1chr1950183845+ENST00000221557PTOV1chr1950361806+966267129551140
ENST00000454376PRMT1chr1950183845+ENST00000600603PTOV1chr1950361806+6772019485158
ENST00000454376PRMT1chr1950183845+ENST00000601638PTOV1chr1950361806+7212019515168
ENST00000454376PRMT1chr1950183845+ENST00000221557PTOV1chr1950361806+9002019485158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532489ENST00000600603PRMT1chr1950183845+PTOV1chr1950361806+0.47856230.5214377
ENST00000532489ENST00000601638PRMT1chr1950183845+PTOV1chr1950361806+0.052240340.94775975
ENST00000532489ENST00000221557PRMT1chr1950183845+PTOV1chr1950361806+0.385946360.61405367
ENST00000391851ENST00000600603PRMT1chr1950183845+PTOV1chr1950361806+0.0298202370.9701798
ENST00000391851ENST00000601638PRMT1chr1950183845+PTOV1chr1950361806+0.0038717330.9961282
ENST00000391851ENST00000221557PRMT1chr1950183845+PTOV1chr1950361806+0.0405762680.9594237
ENST00000454376ENST00000600603PRMT1chr1950183845+PTOV1chr1950361806+0.0223474950.97765243
ENST00000454376ENST00000601638PRMT1chr1950183845+PTOV1chr1950361806+0.0031069520.99689305
ENST00000454376ENST00000221557PRMT1chr1950183845+PTOV1chr1950361806+0.043516440.9564836

Top

Fusion Genomic Features for PRMT1-PTOV1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRMT1chr1950183845+PTOV1chr1950361805+1.20E-050.9999881
PRMT1chr1950183845+PTOV1chr1950361805+1.20E-050.9999881

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PRMT1-PTOV1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50183845/chr19:50361806)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT1chr19:50183845chr19:50361806ENST00000391851+21050_36146354.0DomainSAM-dependent MTase PRMT-type


Top

Fusion Gene Sequence for PRMT1-PTOV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68914_68914_1_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000221557_length(transcript)=966nt_BP=267nt
ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG
GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG
GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC
ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG
GACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACC
AGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGG
AGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGGGGCATGTGGGGGGGGTGGGGTTG
GGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGGTCCTAGGCTGTCGGGAAACTGCA
GCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGATGTGGGGTCAGTGCTTGGGAGCC
TGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGG

>68914_68914_1_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000221557_length(amino acids)=140AA_BP=0
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASS

--------------------------------------------------------------
>68914_68914_2_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000600603_length(transcript)=743nt_BP=267nt
ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG
GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG
GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC
ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG
GACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACC
AGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGG
AGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCT
GAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTT

>68914_68914_2_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000600603_length(amino acids)=140AA_BP=0
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASS

--------------------------------------------------------------
>68914_68914_3_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000601638_length(transcript)=787nt_BP=267nt
ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG
GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG
GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC
ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG
GACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAA
ATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGG
AACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCG
CAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGAC

>68914_68914_3_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000391851_PTOV1_chr19_50361806_ENST00000601638_length(amino acids)=150AA_BP=46
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYK

--------------------------------------------------------------
>68914_68914_4_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000221557_length(transcript)=900nt_BP=201nt
CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT
CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC
GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA
CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACG
GCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGT
TACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTG
GGGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCG
GTCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGG
ATGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGG
GACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTTCCCCAATAAAGCCTTTT

>68914_68914_4_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000221557_length(amino acids)=158AA_BP=0
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS

--------------------------------------------------------------
>68914_68914_5_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000600603_length(transcript)=677nt_BP=201nt
CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT
CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC
GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA
CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACG
GCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGT
TACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACC
CCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAG

>68914_68914_5_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000600603_length(amino acids)=158AA_BP=0
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS

--------------------------------------------------------------
>68914_68914_6_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000601638_length(transcript)=721nt_BP=201nt
CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT
CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC
GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA
CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATG
CTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCC
AACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTC
CAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGC
TTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTAC

>68914_68914_6_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000454376_PTOV1_chr19_50361806_ENST00000601638_length(amino acids)=168AA_BP=64
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS

--------------------------------------------------------------
>68914_68914_7_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000221557_length(transcript)=1259nt_BP=560nt
GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC
TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA
GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG
AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC
AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG
CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC
TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGG
CATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTT
ACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGG
GGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGG
TCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGA
TGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGG

>68914_68914_7_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000221557_length(amino acids)=139AA_BP=
MRPPQRLVSGDPVMYRRDPGACGGGGVGKEAGRPWPWGEQSRGRGSSPSGPRLSGNCSPASGPWEVVSRPGWGQASAHRDVGSVLGSLWP

--------------------------------------------------------------
>68914_68914_8_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000600603_length(transcript)=1036nt_BP=560nt
GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC
TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA
GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG
AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC
AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG
CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC
TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGG
CATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTT
ACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCC
CTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGG

>68914_68914_8_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000600603_length(amino acids)=134AA_BP=1
MTRQREVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASSPMTRAT

--------------------------------------------------------------
>68914_68914_9_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000601638_length(transcript)=1080nt_BP=560nt
GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC
TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA
GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG
AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC
AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG
CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC
TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGC
TCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCA
ACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCC
AGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCT
TCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACG

>68914_68914_9_PRMT1-PTOV1_PRMT1_chr19_50183845_ENST00000532489_PTOV1_chr19_50361806_ENST00000601638_length(amino acids)=144AA_BP=40
MTRQREVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRMT1-PTOV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePTOV1chr19:50183845chr19:50361806ENST00000221557812184_416280.0375.0FLOT1
TgenePTOV1chr19:50183845chr19:50361806ENST00000391842812184_416312.0417.0FLOT1
TgenePTOV1chr19:50183845chr19:50361806ENST00000599732813184_416312.0357.6666666666667FLOT1
TgenePTOV1chr19:50183845chr19:50361806ENST00000600603813184_416280.0365.6666666666667FLOT1
TgenePTOV1chr19:50183845chr19:50361806ENST00000601675813184_416312.0383.6666666666667FLOT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRMT1-PTOV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRMT1-PTOV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource