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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRMT1-TLE6 (FusionGDB2 ID:68915)

Fusion Gene Summary for PRMT1-TLE6

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT1-TLE6
Fusion gene ID: 68915
HgeneTgene
Gene symbol

PRMT1

TLE6

Gene ID

3276

79816

Gene nameprotein arginine methyltransferase 1TLE family member 6, subcortical maternal complex member
SynonymsANM1|HCP1|HRMT1L2|IR1B4GRG6|PREMBL
Cytomap

19q13.33

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 1HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2histone-arginine N-methyltransferase PRMT1interferon receptor 1-bound protein 4transducin-like enhancer protein 6transducin like enhancer of split 6transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000391851, ENST00000454376, 
ENST00000527866, ENST00000532489, 
ENST00000246112, ENST00000452088, 
ENST00000482627, ENST00000478073, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 5=125
# samples 67
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT1 [Title/Abstract] AND TLE6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRMT1(50180573)-TLE6(2978196), # samples:2
Anticipated loss of major functional domain due to fusion event.PRMT1-TLE6 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRMT1-TLE6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRMT1-TLE6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT1

GO:0016571

histone methylation

19405910

HgenePRMT1

GO:0018216

peptidyl-arginine methylation

18657504|19460357|26575292

HgenePRMT1

GO:0043985

histone H4-R3 methylation

11448779

HgenePRMT1

GO:0045652

regulation of megakaryocyte differentiation

26575292

HgenePRMT1

GO:0045653

negative regulation of megakaryocyte differentiation

20442406

HgenePRMT1

GO:0051260

protein homooligomerization

26876602


check buttonFusion gene breakpoints across PRMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TLE6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2857-03APRMT1chr19

50180573

-TLE6chr19

2978196

+
ChimerDB4LAMLTCGA-AB-2857-03APRMT1chr19

50180573

+TLE6chr19

2980098

+
ChimerDB4LAMLTCGA-AB-2857_7009AAAXX_1PRMT1chr19

50180573

+TLE6chr19

2978196

+


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Fusion Gene ORF analysis for PRMT1-TLE6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000391851ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-5UTRENST00000391851ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2980098

+
5CDS-5UTRENST00000391851ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-5UTRENST00000454376ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-5UTRENST00000454376ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2980098

+
5CDS-5UTRENST00000454376ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-intronENST00000391851ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-intronENST00000391851ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2980098

+
5CDS-intronENST00000391851ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-intronENST00000454376ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2978196

+
5CDS-intronENST00000454376ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2980098

+
5CDS-intronENST00000454376ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2978196

+
Frame-shiftENST00000391851ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2980098

+
Frame-shiftENST00000454376ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2980098

+
In-frameENST00000391851ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2980098

+
In-frameENST00000454376ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-3CDSENST00000527866ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-3CDSENST00000527866ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-3CDSENST00000532489ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-3CDSENST00000532489ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-5UTRENST00000527866ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-5UTRENST00000527866ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-5UTRENST00000527866ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-5UTRENST00000532489ENST00000246112PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-5UTRENST00000532489ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-5UTRENST00000532489ENST00000482627PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-intronENST00000527866ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-intronENST00000527866ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-intronENST00000527866ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-intronENST00000532489ENST00000452088PRMT1chr19

50180573

+TLE6chr19

2978196

+
intron-intronENST00000532489ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2980098

+
intron-intronENST00000532489ENST00000478073PRMT1chr19

50180573

+TLE6chr19

2978196

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391851PRMT1chr1950180573+ENST00000246112TLE6chr192980098+20081651291832567
ENST00000454376PRMT1chr1950180573+ENST00000246112TLE6chr192980098+18884591712567

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391851ENST00000246112PRMT1chr1950180573+TLE6chr192980098+0.042365060.9576349
ENST00000454376ENST00000246112PRMT1chr1950180573+TLE6chr192980098+0.0464997440.9535002

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Fusion Genomic Features for PRMT1-TLE6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRMT1chr1950180573+TLE6chr192978195+6.65E-080.9999999
PRMT1chr1950180573+TLE6chr192980097+4.87E-081
PRMT1chr1950180573+TLE6chr192978195+6.65E-080.9999999
PRMT1chr1950180573+TLE6chr192980097+4.87E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRMT1-TLE6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50180573/chr19:2978196)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117284_32217573.0RepeatNote=WD 1
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117332_37217573.0RepeatNote=WD 2
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117377_41617573.0RepeatNote=WD 3
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117419_45617573.0RepeatNote=WD 4
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117458_49717573.0RepeatNote=WD 5
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117499_53817573.0RepeatNote=WD 6
TgeneTLE6chr19:50180573chr19:2980098ENST00000246112117540_57117573.0RepeatNote=WD 7
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016284_3220450.0RepeatNote=WD 1
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016332_3720450.0RepeatNote=WD 2
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016377_4160450.0RepeatNote=WD 3
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016419_4560450.0RepeatNote=WD 4
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016458_4970450.0RepeatNote=WD 5
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016499_5380450.0RepeatNote=WD 6
TgeneTLE6chr19:50180573chr19:2980098ENST00000452088016540_5710450.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT1chr19:50180573chr19:2980098ENST00000391851+11050_36112354.0DomainSAM-dependent MTase PRMT-type


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Fusion Gene Sequence for PRMT1-TLE6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68915_68915_1_PRMT1-TLE6_PRMT1_chr19_50180573_ENST00000391851_TLE6_chr19_2980098_ENST00000246112_length(transcript)=2008nt_BP=165nt
ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG
GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGCCTTGTCCTGGGATC
TCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTTTTCTCCTCATTTTGCTGCG
GAGTTGGAGAGCATTTACTACTCGCTGCACAAGATCCAGCAGGATGTGGCAGAACATCACAAGCAGATAGGAAACGTCTTACAGATTGTG
GAGAGCTGCAGCCAACTCCAGGGTTTCCAGTCTGAGGAGGTCTCACCTGCTGAACCAGCCAGCCCTGGGACGCCCCAGCAGGTGAAGGAC
AAGACCCTGCAGGAGTCGAGCTTTGAGGACATCATGGCCACCAGGTCCTCCGACTGGCTCCGGCGGCCTTTGGGGGAGGACAATCAGCCG
GAGACCCAGCTGTTCTGGGACAAGGAGCCTTGGTTTTGGCACGACACTCTGACCGAGCAACTCTGGCGGATTTTTGCCGGCGTCCACGAT
GAGAAGGCAAAGCCCAGAGACAGACAGCAGGCACCAGGCCTGGGGCAGGAAAGCAAGGCACCAGGATCCTGTGACCCAGGAACAGACCCA
TGTCCTGAAGATGCCTCCACCCCCAGGCCACCTGAGGCCTCCTCCAGTCCCCCTGAGGGTTCCCAAGACAGGAACACAAGTTGGGGTGTG
GTCCAGGAGCCTCCTGGAAGAGCCTCTCGGTTTCTACAGTCCATATCCTGGGACCCTGAGGACTTTGAAGATGCATGGAAGAGGCCAGAT
GCCTTGCCCGGGCAGTCAAAGAGACTCGCCGTCCCGTGCAAACTGGAAAAGATGCGGATCTTGGCACACGGGGAGCTCGTGCTCGCCACG
GCCATCAGCAGCTTCACGCGGCACGTGTTCACCTGTGGCAGAAGAGGCATCAAGGTGTGGAGCCTGACTGGACAGGTGGCTGAGGACAGG
TTCCCTGAGAGCCACCTGCCTATACAGACCCCTGGGGCCTTCCTGCGCACCTGCCTGCTGTCCTCAAACAGCAGGAGCCTGCTCACCGGT
GGCTACAACCTGGCCAGCGTGAGCGTGTGGGACCTGGCGGCGCCCTCCCTGCATGTGAAGGAGCAGTTGCCCTGTGCAGGTCTCAACTGC
CAGGCCCTGGATGCCAACCTGGATGCCAACCTGGCCTTCGCCAGCTTCACCAGTGGTGTGGTCAGGATCTGGGACCTGCGGGATCAGAGT
GTGGTCAGGGACCTCAAGGGTTATCCTGATGGAGTCAAGAGTATCGTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGATGCCTGT
CTGCGGTGCTGGGACCAGAGGACCATCATGAAACCTCTGGAGTACCAATTCAAGTCTCAGATAATGAGCCTGTCCCACAGCCCCCAGGAG
GACTGGGTGCTGCTGGGCATGGCCAATGGCCAGCAGTGGCTGCAAAGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAAGACAGC
GTCATCCTGAGCGTCAAGTTCTCCCCCTTTGGCCAGTGGTGGGCAAGCGTTGGAATGGACGACTTCCTTGGCGTCTACAGCATGCCGGCG
GGGACAAAAGTGTTCGAGGTGCCTGAGATGTCTCCAGTCACGTGCTGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGCTCCGGG
GAGCACGCCTCCGTGTACCAGATCACCTACTGAGGGGCCTCGCTGCTGTCATCCCACTCCGGCTCCTCTTTTCATCCCCCCCCTTCCCCC
CCCCCAACAAGGGGGACATGGTGGAGGGAAGCGGGAAGGCTCTTCTGTGGCATCGCACGATCTAGTCTGTGGTGTAGACTGGTCGCCATC

>68915_68915_1_PRMT1-TLE6_PRMT1_chr19_50180573_ENST00000391851_TLE6_chr19_2980098_ENST00000246112_length(amino acids)=567AA_BP=12
MAAAEAANCIMEPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEE
VSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPG
LGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPC
KLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLA
APSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPL
EYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPV

--------------------------------------------------------------
>68915_68915_2_PRMT1-TLE6_PRMT1_chr19_50180573_ENST00000454376_TLE6_chr19_2980098_ENST00000246112_length(transcript)=1888nt_BP=45nt
CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGCCTTGTCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAAT
TATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTTTTCTCCTCATTTTGCTGCGGAGTTGGAGAGCATTTACTACTCGCTGCAC
AAGATCCAGCAGGATGTGGCAGAACATCACAAGCAGATAGGAAACGTCTTACAGATTGTGGAGAGCTGCAGCCAACTCCAGGGTTTCCAG
TCTGAGGAGGTCTCACCTGCTGAACCAGCCAGCCCTGGGACGCCCCAGCAGGTGAAGGACAAGACCCTGCAGGAGTCGAGCTTTGAGGAC
ATCATGGCCACCAGGTCCTCCGACTGGCTCCGGCGGCCTTTGGGGGAGGACAATCAGCCGGAGACCCAGCTGTTCTGGGACAAGGAGCCT
TGGTTTTGGCACGACACTCTGACCGAGCAACTCTGGCGGATTTTTGCCGGCGTCCACGATGAGAAGGCAAAGCCCAGAGACAGACAGCAG
GCACCAGGCCTGGGGCAGGAAAGCAAGGCACCAGGATCCTGTGACCCAGGAACAGACCCATGTCCTGAAGATGCCTCCACCCCCAGGCCA
CCTGAGGCCTCCTCCAGTCCCCCTGAGGGTTCCCAAGACAGGAACACAAGTTGGGGTGTGGTCCAGGAGCCTCCTGGAAGAGCCTCTCGG
TTTCTACAGTCCATATCCTGGGACCCTGAGGACTTTGAAGATGCATGGAAGAGGCCAGATGCCTTGCCCGGGCAGTCAAAGAGACTCGCC
GTCCCGTGCAAACTGGAAAAGATGCGGATCTTGGCACACGGGGAGCTCGTGCTCGCCACGGCCATCAGCAGCTTCACGCGGCACGTGTTC
ACCTGTGGCAGAAGAGGCATCAAGGTGTGGAGCCTGACTGGACAGGTGGCTGAGGACAGGTTCCCTGAGAGCCACCTGCCTATACAGACC
CCTGGGGCCTTCCTGCGCACCTGCCTGCTGTCCTCAAACAGCAGGAGCCTGCTCACCGGTGGCTACAACCTGGCCAGCGTGAGCGTGTGG
GACCTGGCGGCGCCCTCCCTGCATGTGAAGGAGCAGTTGCCCTGTGCAGGTCTCAACTGCCAGGCCCTGGATGCCAACCTGGATGCCAAC
CTGGCCTTCGCCAGCTTCACCAGTGGTGTGGTCAGGATCTGGGACCTGCGGGATCAGAGTGTGGTCAGGGACCTCAAGGGTTATCCTGAT
GGAGTCAAGAGTATCGTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGATGCCTGTCTGCGGTGCTGGGACCAGAGGACCATCATG
AAACCTCTGGAGTACCAATTCAAGTCTCAGATAATGAGCCTGTCCCACAGCCCCCAGGAGGACTGGGTGCTGCTGGGCATGGCCAATGGC
CAGCAGTGGCTGCAAAGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAAGACAGCGTCATCCTGAGCGTCAAGTTCTCCCCCTTT
GGCCAGTGGTGGGCAAGCGTTGGAATGGACGACTTCCTTGGCGTCTACAGCATGCCGGCGGGGACAAAAGTGTTCGAGGTGCCTGAGATG
TCTCCAGTCACGTGCTGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGCTCCGGGGAGCACGCCTCCGTGTACCAGATCACCTAC
TGAGGGGCCTCGCTGCTGTCATCCCACTCCGGCTCCTCTTTTCATCCCCCCCCTTCCCCCCCCCCAACAAGGGGGACATGGTGGAGGGAA

>68915_68915_2_PRMT1-TLE6_PRMT1_chr19_50180573_ENST00000454376_TLE6_chr19_2980098_ENST00000246112_length(amino acids)=567AA_BP=12
MAAAEAANCIMEPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEE
VSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPG
LGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPC
KLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLA
APSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPL
EYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRMT1-TLE6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRMT1-TLE6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRMT1-TLE6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource