Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRMT2-DIP2A (FusionGDB2 ID:68918)

Fusion Gene Summary for PRMT2-DIP2A

Fusion gene summary

Fusion gene information	Fusion gene name: PRMT2-DIP2A
	Fusion gene ID: 68918
		Hgene	Tgene
	Gene symbol	PRMT2	DIP2A
	Gene ID	3275	23181
	Gene name	protein arginine methyltransferase 2	disco interacting protein 2 homolog A
	Synonyms	HRMT1L1	C21orf106\|DIP2
	Cytomap	21q22.3	21q22.3
	Type of gene	protein-coding	protein-coding
	Description	protein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2	disco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2A
	Modification date	20200313	20200313
	UniProtAcc	.	Q14689
	Ensembl transtripts involved in fusion gene	ENST00000291705, ENST00000334494, ENST00000355680, ENST00000397628, ENST00000397637, ENST00000397638, ENST00000440086, ENST00000451211, ENST00000458387, ENST00000491389,	ENST00000479654, ENST00000318711, ENST00000417564, ENST00000427143, ENST00000435722, ENST00000457905, ENST00000466639, ENST00000400274,
Fusion gene scores	* DoF score	11 X 9 X 7=693	6 X 7 X 4=168
	# samples	12	7
	** MAII score	log2(12/693*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PRMT2 [Title/Abstract] AND DIP2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRMT2(48064400)-DIP2A(47985626), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRMT2	GO:0016571	histone methylation	19405910
Hgene	PRMT2	GO:0032088	negative regulation of NF-kappaB transcription factor activity	16648481
Hgene	PRMT2	GO:0045892	negative regulation of transcription, DNA-templated	16648481
Hgene	PRMT2	GO:0045893	positive regulation of transcription, DNA-templated	12039952
Hgene	PRMT2	GO:0060765	regulation of androgen receptor signaling pathway	17587566
Tgene	DIP2A	GO:0010629	negative regulation of gene expression	20860622

Fusion gene breakpoints across PRMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DIP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A0U4-01A	PRMT2	chr21	48064400	-	DIP2A	chr21	47985626	+
ChimerDB4	BRCA	TCGA-AR-A0U4-01A	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
ChimerDB4	BRCA	TCGA-AR-A0U4	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+

Top

Fusion Gene ORF analysis for PRMT2-DIP2A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000291705	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000291705	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000334494	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000334494	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000355680	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000355680	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000397628	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000397628	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000397637	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000397637	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000397638	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000397638	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000440086	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000440086	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000451211	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000451211	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-3UTR	ENST00000458387	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-3UTR	ENST00000458387	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000291705	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000291705	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000334494	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000334494	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000355680	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000355680	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397628	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397628	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397637	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397637	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000397638	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000397638	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000440086	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000440086	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000451211	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000451211	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
5CDS-intron	ENST00000458387	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
5CDS-intron	ENST00000458387	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000291705	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000291705	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000334494	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000334494	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000355680	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000355680	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000397628	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000397628	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000397637	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000397637	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000397638	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000397638	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000440086	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000440086	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000451211	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000451211	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
In-frame	ENST00000458387	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
In-frame	ENST00000458387	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-3CDS	ENST00000491389	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-3CDS	ENST00000491389	ENST00000400274	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-3UTR	ENST00000491389	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-3UTR	ENST00000491389	ENST00000479654	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000318711	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000417564	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000427143	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000435722	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000457905	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+
intron-intron	ENST00000491389	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985626	+
intron-intron	ENST00000491389	ENST00000466639	PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for PRMT2-DIP2A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+	5.26E-07	0.9999995
PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+	5.26E-07	0.9999995
PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+	5.26E-07	0.9999995
PRMT2	chr21	48064400	+	DIP2A	chr21	47985625	+	5.26E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PRMT2-DIP2A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:48064400/chr21:47985626)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DIP2A Q14689
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250\|UniProtKB:Q8BWT5, ECO:0000269\|PubMed:20054002}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000334494

30_89

109

285.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000355680

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000397637

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000397638

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000440086

30_89

109

332.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000334494

30_89

109

285.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000355680

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000397637

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000397638

30_89

109

434.0

Domain

SH3

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000440086

30_89

109

332.0

Domain

SH3

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000400274

1498_1501

1384

1568.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000417564

1498_1501

1388

1572.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000427143

1114_1117

1111.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000427143

1498_1501

1111.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000435722

1114_1117

842.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000435722

1498_1501

842.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000457905

1114_1117

890.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000457905

1498_1501

890.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000466639

1114_1117

799.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000466639

1498_1501

799.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000400274

1498_1501

1384

1568.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000417564

1498_1501

1388

1572.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000427143

1114_1117

1111.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000427143

1498_1501

1111.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000435722

1114_1117

842.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000435722

1498_1501

842.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000457905

1114_1117

890.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000457905

1498_1501

890.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000466639

1114_1117

799.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000466639

1498_1501

799.0

Compositional bias

Note=Poly-Val

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000427143

9_127

1111.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000435722

9_127

842.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000457905

9_127

890.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000466639

9_127

799.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000427143

9_127

1111.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000435722

9_127

842.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000457905

9_127

890.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000466639

9_127

799.0

Domain

DMAP1-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000334494

99_432

109

285.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000355680

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000397637

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000397638

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985625

ENST00000440086

99_432

109

332.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000334494

99_432

109

285.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000355680

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000397637

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000397638

99_432

109

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48064400

chr21:47985626

ENST00000440086

99_432

109

332.0

Domain

SAM-dependent MTase PRMT-type

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000400274

1114_1117

1384

1568.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000417564

1114_1117

1388

1572.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000400274

1114_1117

1384

1568.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000417564

1114_1117

1388

1572.0

Compositional bias

Note=Poly-Ala

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000400274

9_127

1384

1568.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985625

ENST00000417564

9_127

1388

1572.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000400274

9_127

1384

1568.0

Domain

DMAP1-binding

Tgene

DIP2A

chr21:48064400

chr21:47985626

ENST00000417564

9_127

1388

1572.0

Domain

DMAP1-binding

Top

Fusion Gene Sequence for PRMT2-DIP2A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for PRMT2-DIP2A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000334494	+	4	7	133_275	109.0	285.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000334494	+	4	7	1_277	109.0	285.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000355680	+	5	12	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000355680	+	5	12	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397637	+	4	11	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397637	+	4	11	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397638	+	4	11	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397638	+	4	11	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000440086	+	4	9	133_275	109.0	332.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000440086	+	4	9	1_277	109.0	332.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000334494	+	4	7	133_275	109.0	285.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000334494	+	4	7	1_277	109.0	285.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000355680	+	5	12	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000355680	+	5	12	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397637	+	4	11	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397637	+	4	11	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397638	+	4	11	133_275	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397638	+	4	11	1_277	109.0	434.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000440086	+	4	9	133_275	109.0	332.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000440086	+	4	9	1_277	109.0	332.0	ESR1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000334494	+	4	7	83_207	109.0	285.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000355680	+	5	12	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397637	+	4	11	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000397638	+	4	11	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985625	ENST00000440086	+	4	9	83_207	109.0	332.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000334494	+	4	7	83_207	109.0	285.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000355680	+	5	12	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397637	+	4	11	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000397638	+	4	11	83_207	109.0	434.0	RB1
Hgene	PRMT2	chr21:48064400	chr21:47985626	ENST00000440086	+	4	9	83_207	109.0	332.0	RB1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PRMT2-DIP2A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PRMT2-DIP2A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source