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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRMT2-GAPDH (FusionGDB2 ID:68920)

Fusion Gene Summary for PRMT2-GAPDH

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT2-GAPDH
Fusion gene ID: 68920
HgeneTgene
Gene symbol

PRMT2

GAPDH

Gene ID

3275

2597

Gene nameprotein arginine methyltransferase 2glyceraldehyde-3-phosphate dehydrogenase
SynonymsHRMT1L1G3PD|GAPD|HEL-S-162eP
Cytomap

21q22.3

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
Modification date2020031320200327
UniProtAcc.

P04406

Ensembl transtripts involved in fusion geneENST00000355680, ENST00000397637, 
ENST00000397638, ENST00000440086, 
ENST00000291705, ENST00000334494, 
ENST00000397628, ENST00000451211, 
ENST00000458387, ENST00000491389, 
ENST00000396856, ENST00000396858, 
ENST00000396859, ENST00000396861, 
ENST00000229239, 
Fusion gene scores* DoF score11 X 9 X 7=69327 X 29 X 8=6264
# samples 1231
** MAII scorelog2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/6264*10)=-4.3367440920168
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT2 [Title/Abstract] AND GAPDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRMT2(48081784)-GAPDH(6645706), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT2

GO:0016571

histone methylation

19405910

HgenePRMT2

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16648481

HgenePRMT2

GO:0045892

negative regulation of transcription, DNA-templated

16648481

HgenePRMT2

GO:0045893

positive regulation of transcription, DNA-templated

12039952

HgenePRMT2

GO:0060765

regulation of androgen receptor signaling pathway

17587566

TgeneGAPDH

GO:0010951

negative regulation of endopeptidase activity

22832495

TgeneGAPDH

GO:0017148

negative regulation of translation

23071094

TgeneGAPDH

GO:0031640

killing of cells of other organism

22832495

TgeneGAPDH

GO:0050715

positive regulation of cytokine secretion

22832495

TgeneGAPDH

GO:0050832

defense response to fungus

22832495

TgeneGAPDH

GO:0051873

killing by host of symbiont cells

22832495

TgeneGAPDH

GO:0052501

positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction

22832495

TgeneGAPDH

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

22832495

TgeneGAPDH

GO:0071346

cellular response to interferon-gamma

15479637


check buttonFusion gene breakpoints across PRMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GAPDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE255519PRMT2chr21

48081784

+GAPDHchr12

6645706

+


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Fusion Gene ORF analysis for PRMT2-GAPDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355680ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000355680ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000355680ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000355680ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397637ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397637ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397637ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397637ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397638ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397638ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397638ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000397638ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000440086ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000440086ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000440086ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
5CDS-5UTRENST00000440086ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
In-frameENST00000355680ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
In-frameENST00000397637ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
In-frameENST00000397638ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
In-frameENST00000440086ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000291705ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000334494ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000397628ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000451211ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000458387ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-3CDSENST00000491389ENST00000229239PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000291705ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000291705ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000291705ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000291705ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000334494ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000334494ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000334494ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000334494ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000397628ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000397628ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000397628ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000397628ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000451211ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000451211ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000451211ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000451211ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000458387ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000458387ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000458387ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000458387ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000491389ENST00000396856PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000491389ENST00000396858PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000491389ENST00000396859PRMT2chr21

48081784

+GAPDHchr12

6645706

+
intron-5UTRENST00000491389ENST00000396861PRMT2chr21

48081784

+GAPDHchr12

6645706

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355680PRMT2chr2148081784+ENST00000229239GAPDHchr126645706+291917867622717651
ENST00000397638PRMT2chr2148081784+ENST00000229239GAPDHchr126645706+236212292052160651
ENST00000397637PRMT2chr2148081784+ENST00000229239GAPDHchr126645706+311119789542909651
ENST00000440086PRMT2chr2148081784+ENST00000229239GAPDHchr126645706+19908571391788549

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355680ENST00000229239PRMT2chr2148081784+GAPDHchr126645706+0.0088961350.9911039
ENST00000397638ENST00000229239PRMT2chr2148081784+GAPDHchr126645706+0.0104533110.9895467
ENST00000397637ENST00000229239PRMT2chr2148081784+GAPDHchr126645706+0.0079157130.99208426
ENST00000440086ENST00000229239PRMT2chr2148081784+GAPDHchr126645706+0.010489740.9895103

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Fusion Genomic Features for PRMT2-GAPDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRMT2-GAPDH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:48081784/chr12:6645706)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GAPDH

P04406

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000250, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:3170585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGAPDHchr21:48081784chr12:6645706ENST0000022923909245_2500336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685808245_2500294.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685908245_2500336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039686109245_2500336.0Motif[IL]-x-C-x-x-[DE] motif
TgeneGAPDHchr21:48081784chr12:6645706ENST000002292390913_140336.0Nucleotide bindingNAD
TgeneGAPDHchr21:48081784chr12:6645706ENST000003968580813_140294.0Nucleotide bindingNAD
TgeneGAPDHchr21:48081784chr12:6645706ENST000003968590813_140336.0Nucleotide bindingNAD
TgeneGAPDHchr21:48081784chr12:6645706ENST000003968610913_140336.0Nucleotide bindingNAD
TgeneGAPDHchr21:48081784chr12:6645706ENST0000022923909151_1530336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000022923909211_2120336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685808151_1530294.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685808211_2120294.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685908151_1530336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039685908211_2120336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039686109151_1530336.0RegionGlyceraldehyde 3-phosphate binding
TgeneGAPDHchr21:48081784chr12:6645706ENST0000039686109211_2120336.0RegionGlyceraldehyde 3-phosphate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT2chr21:48081784chr12:6645706ENST00000334494+1730_890285.0DomainSH3
HgenePRMT2chr21:48081784chr12:6645706ENST00000334494+1799_4320285.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48081784chr12:6645706ENST00000355680+11230_890434.0DomainSH3
HgenePRMT2chr21:48081784chr12:6645706ENST00000355680+11299_4320434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48081784chr12:6645706ENST00000397637+11130_890434.0DomainSH3
HgenePRMT2chr21:48081784chr12:6645706ENST00000397637+11199_4320434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48081784chr12:6645706ENST00000397638+11130_890434.0DomainSH3
HgenePRMT2chr21:48081784chr12:6645706ENST00000397638+11199_4320434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48081784chr12:6645706ENST00000440086+1930_890332.0DomainSH3
HgenePRMT2chr21:48081784chr12:6645706ENST00000440086+1999_4320332.0DomainSAM-dependent MTase PRMT-type


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Fusion Gene Sequence for PRMT2-GAPDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68920_68920_1_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000355680_GAPDH_chr12_6645706_ENST00000229239_length(transcript)=2919nt_BP=1786nt
ACTTATCCAGAAGAAAGGCAGAGGGCGCACACTGCGCAGCGCGGATGGGAAAGTTAACTGAATTATTTGCGGGAAGACAGAGGAGGTGGG
GGGTCCCCCAAGCCCCAGCCATTTTGTGGCTCGTAGGGGTTGTCGCTTCCCAAGCCGTGAATGGCCCAAACCCGCCCCCCGCCCCAGGTC
GGACTCCTGCCCCGCGCCCCTCTGGGTCGGACCCCAAGCCGAGCCCCCCAACCCCGCGGCTGGGCTGGGCGATTGGGGACGAGCTCCACA
CATGGAGAACCTGGCCTCGCCTCGCAAGACCGCGGGACGCGCAGATGTGAAGTGCGCCTGCGCGGGGCGCAGCCCCAGCTGCAGACGATC
TGTGAGCGACGCGCCGGCGCAAGTCGAGGGCGGTGGCTTGGCTTCCCTGGAATGGGGGACGTCTTAGGACTGCGCCTGCGCGGGGCGCCG
GGCCCTGGGCGGGGCCTTCCCGGCTGACGGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCG
TCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAGCAGTGTGTGGATTACACTATCACTGGAAAAA
TACGAATTGAGAAGAAGGAAAAGACTGGAAGATGCAGACCTTGGTTCCTGTTAGTGGAAACACTGTAAGGTCCCAGAAATGGAAAAGAAA
ATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAG
CCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAG
ACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGT
GGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTAT
GGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTG
ACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCG
GTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTG
GAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGTTTGAGTTCATGATCGAGTCCATC
CTGTATGCCCGGGATGCCTGGCTGAAGGAGGACGGGGTCATTTGGCCCACCATGGCTGCGTTGCACCTTGTGCCCTGCAGTGCTGATAAG
GATTATCGTAGCAAGGTGCTCTTCTGGGACAACGCGTACGAGTTCAACCTCAGCGCTCTGAAATCTTTAGCAGTTAAGGAGTTTTTTTCA
AAGCCCAAGTATAACCACATTTTGAAACCAGAAGACTGTCTCTCTGAACCGTGCACTATATTGCAGTTGGACATGAGAACCGTGCAAATT
TCTGATCTAGAGTCCACTTCCAGAGCCTGCAGGAGGGGCAGCCGCCGCAGGTGCTCAGCACCGGGCCCTTCCACCCGTAAAGTGGATATT
GTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTC
AAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCT
GGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATC
ATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCC
TCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCC
ATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCT
ACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTG
TCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTC
AAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGC
ATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCAC
ATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGC
CACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACC

>68920_68920_1_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000355680_GAPDH_chr12_6645706_ENST00000229239_length(amino acids)=651AA_BP=327
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYE
FNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLESTSRACRRGSRRRCSAPGPSTRKVDIVAINDPFIDLNYMV
YMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMG
VNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPEL
NGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWY

--------------------------------------------------------------
>68920_68920_2_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000397637_GAPDH_chr12_6645706_ENST00000229239_length(transcript)=3111nt_BP=1978nt
GCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGA
ACTCAGCGGAGAAACGCGATTGAGGTAGGTGTCCTGATGGGCAGCTCAGATGGCTGGACTGCACGTAAGGAAGGACAGGCCAGGTGAGGC
GTCCTCGCACTGCGTGTGCGTCGCTGGCGGACAGAGGCCTCCGCCCCCTTTTGGGACCTCCGAGCGCCTTCGCGATCTCAGCCACTTTCC
CTGGCGTCCAAACGGGAGCTCGGTCCCCGTCACACCCTTCCCTGCGTGCCGCACCCCTTCCCGGCCACTCCCGCCGTCCAGCGCCTTCTA
CGGCCACGCCCACCCCACCACCATCTCTGTCACGCCCTTCGCGGCCACGCCCACCTGCCTGGCGGCCCCTGCCCCGAAGCTCGCGGCGCT
GTCCCAGCCTGACCCTCTCGTGCCCCTGCGTCCACGCGTGGCCCTCTCGCTTCCTGCCCCCTTCTCACCCCCCTTCACTGGCCACCTGTT
CCAACCCTCCATGATCCTGTTCCTCCCGAGGGCATCTTAGGAGGGCAGGGTCCTGCGCGCACTGCGGCCTCCACTCCGACCCCGTCCCAG
TTTGGACCCAGGTCTTCCAATGAAAATATAATTATGCAAATCAGTAAGCATTTGTAACTACGAATATCACAAAAATAAGCTTCAAGTCTG
GATTTAGAAGTGAAGCATGCATTTTAAACAAAGAATTGCTATGCAATTTTAAAAACACATTGATCCCAGAGCAGTGTGTGGATTACACTA
TCACTGGAAAAATACGAATTGAGAAGAAGGAAAAGACTGGAAGATGCAGACCTTGGTTCCTGTTAGTGGAAACACTGTAAGGTCCCAGAA
ATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCG
CAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCT
GCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGT
GCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTAC
TTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAAT
AAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGA
GCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTAC
CAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGTTTGAGTTCATG
ATCGAGTCCATCCTGTATGCCCGGGATGCCTGGCTGAAGGAGGACGGGGTCATTTGGCCCACCATGGCTGCGTTGCACCTTGTGCCCTGC
AGTGCTGATAAGGATTATCGTAGCAAGGTGCTCTTCTGGGACAACGCGTACGAGTTCAACCTCAGCGCTCTGAAATCTTTAGCAGTTAAG
GAGTTTTTTTCAAAGCCCAAGTATAACCACATTTTGAAACCAGAAGACTGTCTCTCTGAACCGTGCACTATATTGCAGTTGGACATGAGA
ACCGTGCAAATTTCTGATCTAGAGTCCACTTCCAGAGCCTGCAGGAGGGGCAGCCGCCGCAGGTGCTCAGCACCGGGCCCTTCCACCCGT
AAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTC
CATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAG
TGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCC
AAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATC
ATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACC
ACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATC
ATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCC
ACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCG
GAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGAC
GCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGAC
CTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTG
GGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTA

>68920_68920_2_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000397637_GAPDH_chr12_6645706_ENST00000229239_length(amino acids)=651AA_BP=327
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYE
FNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLESTSRACRRGSRRRCSAPGPSTRKVDIVAINDPFIDLNYMV
YMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMG
VNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPEL
NGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWY

--------------------------------------------------------------
>68920_68920_3_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000397638_GAPDH_chr12_6645706_ENST00000229239_length(transcript)=2362nt_BP=1229nt
CGGGCCCTGGGCGGGGCCTTCCCGGCTGACGGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGAC
CGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAG
TTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGA
GGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTT
GAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAA
CCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCA
CTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCT
GGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGAT
GGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCC
CGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGTTTGAGTTCATGATCGAGTCCATCCTGTATGCCCGGGATGC
CTGGCTGAAGGAGGACGGGGTCATTTGGCCCACCATGGCTGCGTTGCACCTTGTGCCCTGCAGTGCTGATAAGGATTATCGTAGCAAGGT
GCTCTTCTGGGACAACGCGTACGAGTTCAACCTCAGCGCTCTGAAATCTTTAGCAGTTAAGGAGTTTTTTTCAAAGCCCAAGTATAACCA
CATTTTGAAACCAGAAGACTGTCTCTCTGAACCGTGCACTATATTGCAGTTGGACATGAGAACCGTGCAAATTTCTGATCTAGAGTCCAC
TTCCAGAGCCTGCAGGAGGGGCAGCCGCCGCAGGTGCTCAGCACCGGGCCCTTCCACCCGTAAAGTGGATATTGTTGCCATCAATGACCC
CTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAA
GCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGT
GGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGC
TGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTG
CTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCCATCACTGCCACCCAGAA
GACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGC
TGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGAC
CTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTA
CACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCA
CTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTA
AGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCAC
CACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACCTTGTCATGTACCATCAA

>68920_68920_3_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000397638_GAPDH_chr12_6645706_ENST00000229239_length(amino acids)=651AA_BP=327
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYE
FNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLESTSRACRRGSRRRCSAPGPSTRKVDIVAINDPFIDLNYMV
YMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMG
VNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPEL
NGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWY

--------------------------------------------------------------
>68920_68920_4_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000440086_GAPDH_chr12_6645706_ENST00000229239_length(transcript)=1990nt_BP=857nt
GTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGA
AAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGG
AGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCAC
CGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGG
CTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGG
CAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGA
ATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGT
GTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCA
GAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGTCCACTTCCAGAGCCTG
CAGGAGGGGCAGCCGCCGCAGGTGCTCAGCACCGGGCCCTTCCACCCGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCT
CAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAA
TGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGG
CGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCAT
GTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCT
GGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGG
CCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGT
CATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGA
AAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCA
GGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCT
CATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGAC
CACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCT
CCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACCTTGTCATGTACCATCAATAAAGTACCCTG

>68920_68920_4_PRMT2-GAPDH_PRMT2_chr21_48081784_ENST00000440086_GAPDH_chr12_6645706_ENST00000229239_length(amino acids)=549AA_BP=225
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLSTSRACRRGSRRRCSAPGPSTRKVDIVAINDPFIDLNYMVYMFQYDSTHGKF
HGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKI
ISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVP
TANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRMT2-GAPDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneGAPDHchr21:48081784chr12:6645706ENST00000229239092_1480336.0WARS1
TgeneGAPDHchr21:48081784chr12:6645706ENST00000396858082_1480294.0WARS1
TgeneGAPDHchr21:48081784chr12:6645706ENST00000396859082_1480336.0WARS1
TgeneGAPDHchr21:48081784chr12:6645706ENST00000396861092_1480336.0WARS1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePRMT2chr21:48081784chr12:6645706ENST00000334494+17133_2750285.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000334494+171_2770285.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000355680+112133_2750434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000355680+1121_2770434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397637+111133_2750434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397637+1111_2770434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397638+111133_2750434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397638+1111_2770434.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000440086+19133_2750332.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000440086+191_2770332.0ESR1
HgenePRMT2chr21:48081784chr12:6645706ENST00000334494+1783_2070285.0RB1
HgenePRMT2chr21:48081784chr12:6645706ENST00000355680+11283_2070434.0RB1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397637+11183_2070434.0RB1
HgenePRMT2chr21:48081784chr12:6645706ENST00000397638+11183_2070434.0RB1
HgenePRMT2chr21:48081784chr12:6645706ENST00000440086+1983_2070332.0RB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRMT2-GAPDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRMT2-GAPDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource