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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRMT2-SLC41A2 (FusionGDB2 ID:68924)

Fusion Gene Summary for PRMT2-SLC41A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT2-SLC41A2
Fusion gene ID: 68924
HgeneTgene
Gene symbol

PRMT2

SLC41A2

Gene ID

3275

84102

Gene nameprotein arginine methyltransferase 2solute carrier family 41 member 2
SynonymsHRMT1L1SLC41A1-L1
Cytomap

21q22.3

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2solute carrier family 41 member 2SLC41A1-like 1solute carrier family 41 (magnesium transporter), member 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000491389, ENST00000291705, 
ENST00000334494, ENST00000355680, 
ENST00000397628, ENST00000397637, 
ENST00000397638, ENST00000440086, 
ENST00000451211, ENST00000458387, 
ENST00000258538, ENST00000549713, 
Fusion gene scores* DoF score11 X 9 X 7=6933 X 3 X 4=36
# samples 124
** MAII scorelog2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRMT2 [Title/Abstract] AND SLC41A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRMT2(48069651)-SLC41A2(105199115), # samples:1
Anticipated loss of major functional domain due to fusion event.PRMT2-SLC41A2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRMT2-SLC41A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRMT2-SLC41A2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRMT2-SLC41A2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PRMT2-SLC41A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT2

GO:0016571

histone methylation

19405910

HgenePRMT2

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16648481

HgenePRMT2

GO:0045892

negative regulation of transcription, DNA-templated

16648481

HgenePRMT2

GO:0045893

positive regulation of transcription, DNA-templated

12039952

HgenePRMT2

GO:0060765

regulation of androgen receptor signaling pathway

17587566


check buttonFusion gene breakpoints across PRMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC41A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AL-01APRMT2chr21

48069651

+SLC41A2chr12

105199115

-


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Fusion Gene ORF analysis for PRMT2-SLC41A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000491389ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
3UTR-5UTRENST00000491389ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000291705ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000334494ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000355680ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000397628ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000397637ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000397638ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000440086ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000451211ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
5CDS-5UTRENST00000458387ENST00000549713PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
Frame-shiftENST00000397628ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000291705ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000334494ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000355680ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000397637ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000397638ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000440086ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000451211ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-
In-frameENST00000458387ENST00000258538PRMT2chr21

48069651

+SLC41A2chr12

105199115

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355680PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-420114167621601279
ENST00000397638PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-36448592051044279
ENST00000291705PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-36148291751014279
ENST00000458387PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-36148291751014279
ENST00000451211PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-36148291751014279
ENST00000397637PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-439316089541793279
ENST00000334494PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-36068211671006279
ENST00000440086PRMT2chr2148069651+ENST00000258538SLC41A2chr12105199115-3578793139978279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355680ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0017264660.9982735
ENST00000397638ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011842420.9988158
ENST00000291705ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011527680.99884725
ENST00000458387ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011527680.99884725
ENST00000451211ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011527680.99884725
ENST00000397637ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0016552380.9983448
ENST00000334494ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011465040.99885345
ENST00000440086ENST00000258538PRMT2chr2148069651+SLC41A2chr12105199115-0.0011951520.9988048

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Fusion Genomic Features for PRMT2-SLC41A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRMT2-SLC41A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:48069651/chr12:105199115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT2chr21:48069651chr12:105199115ENST00000334494+6730_89218285.0DomainSH3
HgenePRMT2chr21:48069651chr12:105199115ENST00000355680+71230_89218434.0DomainSH3
HgenePRMT2chr21:48069651chr12:105199115ENST00000397637+61130_89218434.0DomainSH3
HgenePRMT2chr21:48069651chr12:105199115ENST00000397638+61130_89218434.0DomainSH3
HgenePRMT2chr21:48069651chr12:105199115ENST00000440086+6930_89218332.0DomainSH3
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810520_543512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810565_573512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810544_564512574.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT2chr21:48069651chr12:105199115ENST00000334494+6799_432218285.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48069651chr12:105199115ENST00000355680+71299_432218434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48069651chr12:105199115ENST00000397637+61199_432218434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48069651chr12:105199115ENST00000397638+61199_432218434.0DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48069651chr12:105199115ENST00000440086+6999_432218332.0DomainSAM-dependent MTase PRMT-type
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810184_195512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST000002585388101_162512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810217_245512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810267_282512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810304_313512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810335_347512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810369_376512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810398_406512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810428_469512574.0Topological domainExtracellular
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810491_498512574.0Topological domainCytoplasmic
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810163_183512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810196_216512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810246_266512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810283_303512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810314_334512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810348_368512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810377_397512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810407_427512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810470_490512574.0TransmembraneHelical
TgeneSLC41A2chr21:48069651chr12:105199115ENST00000258538810499_519512574.0TransmembraneHelical


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Fusion Gene Sequence for PRMT2-SLC41A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68924_68924_1_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000291705_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3614nt_BP=829nt
GGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGAC
GCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGC
AACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCC
AGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACA
AACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGA
CCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAAC
AACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAG
TCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCA
GAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTG
GATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAG
TTTCTCCATCCCCTACCTAACAGCATTGGGTGATCTGCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGA
TCGAGATGGAGATGTTGGAGACTAATAAATTCTACAAACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTT
TTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAA
GGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCA
GCTCTGAAATTAATTAGGAAAGAATATAGGATGTTTACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAA
TTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAA
GAGTGCCCAACCAAGCTTTGAATCGTATTAACAATGCCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGA
CCTAAATATGTTTTGCTGAGCATAAGATAAACTCACTTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTG
CAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTGATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGT
TGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAA
TGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAA
TATCAGCAATATAGAGTTATTCTTAAACACATTCTATTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACT
ATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTG
ATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCAC
AACGCCCAGCTAATTTGTTACCTACACTCTAATTAATAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAG
GAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAA
TTATTGTTCATGCTTAAACATATCCATTTGTACAGGCTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTC
TAAAACTCTGGCCTATATTCTAAACACTTGACCAACACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTA
AAATTCAATCTCTCAAGACCGTTAGATATTTAATAATTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAA
GTTGTAACTTTGTGTTATTATATAAATATTAGGTTGTTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGAC
TGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAAACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACT
GAACTAATTATAGAATTTCTCCTTTGGAGAGTTATAATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAAT
ATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCATGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTG
TAAGATTCATAAACATTTACATTTCCCAATGATTTCTATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATC
AACAACTTTATTATATTACACATTCCAGTGCACAAACACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGAT
ATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAATTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGA
AGTCCCTAACATCCAGGTTTTCATAATGCCAGTACTCTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATT
CACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCC
GTTTATTATATCCTGATGGTGAGTATTGCCAGCTCTAAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAA
ATAAAGAACAATGCCTTAATTTGTAAAATCTATCATTGCTACCACCCTGCCCAGGTCTGGCCATTTGCCATAAATGCTGGTAAATAAATA

>68924_68924_1_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000291705_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_2_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000334494_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3606nt_BP=821nt
TGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACT
CAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAG
GTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGT
TTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTG
CAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGG
ACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAAT
ACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCT
GTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCT
TTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGA
CCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAGTTTCTCCA
TCCCCTACCTAACAGCATTGGGTGATCTGCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGATCGAGATG
GAGATGTTGGAGACTAATAAATTCTACAAACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTTTTTCAAAA
CTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAAGGAATTTG
TGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCAGCTCTGAA
ATTAATTAGGAAAGAATATAGGATGTTTACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAATTTGTAAT
GCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAAGAGTGCCC
AACCAAGCTTTGAATCGTATTAACAATGCCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGACCTAAATA
TGTTTTGCTGAGCATAAGATAAACTCACTTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTGCAAGTTCT
TGTCAGGCTAATCTTTAAACATTGAGTGATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGTTGGAAAAA
TGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAATGTGTGTG
TGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAATATCAGCA
ATATAGAGTTATTCTTAAACACATTCTATTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACTATTTGTTA
CCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTGATCTCGGC
TCACTGCTACCTCCACCTCCTGGATTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCACAACGCCCA
GCTAATTTGTTACCTACACTCTAATTAATAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAGGAGATTTA
AAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAATTATTGTT
CATGCTTAAACATATCCATTTGTACAGGCTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTCTAAAACTC
TGGCCTATATTCTAAACACTTGACCAACACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTAAAATTCAA
TCTCTCAAGACCGTTAGATATTTAATAATTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAAGTTGTAAC
TTTGTGTTATTATATAAATATTAGGTTGTTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGACTGTGGTTT
AGAGTTATATATTTTTGCTTATTTTTAAACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACTGAACTAAT
TATAGAATTTCTCCTTTGGAGAGTTATAATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAATATTTAGCT
GCAAAGATTTTTTACTTAAAAAAATCCATGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTGTAAGATTC
ATAAACATTTACATTTCCCAATGATTTCTATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATCAACAACTT
TATTATATTACACATTCCAGTGCACAAACACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGATATTCCTAT
CTCTATTTTACAGCAGAGGAAACCGAAATTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGAAGTCCCTA
ACATCCAGGTTTTCATAATGCCAGTACTCTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATTCACTGAGA
GGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCCGTTTATTA
TATCCTGATGGTGAGTATTGCCAGCTCTAAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAAATAAAGAA
CAATGCCTTAATTTGTAAAATCTATCATTGCTACCACCCTGCCCAGGTCTGGCCATTTGCCATAAATGCTGGTAAATAAATACAATGACT

>68924_68924_2_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000334494_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_3_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000355680_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=4201nt_BP=1416nt
ACTTATCCAGAAGAAAGGCAGAGGGCGCACACTGCGCAGCGCGGATGGGAAAGTTAACTGAATTATTTGCGGGAAGACAGAGGAGGTGGG
GGGTCCCCCAAGCCCCAGCCATTTTGTGGCTCGTAGGGGTTGTCGCTTCCCAAGCCGTGAATGGCCCAAACCCGCCCCCCGCCCCAGGTC
GGACTCCTGCCCCGCGCCCCTCTGGGTCGGACCCCAAGCCGAGCCCCCCAACCCCGCGGCTGGGCTGGGCGATTGGGGACGAGCTCCACA
CATGGAGAACCTGGCCTCGCCTCGCAAGACCGCGGGACGCGCAGATGTGAAGTGCGCCTGCGCGGGGCGCAGCCCCAGCTGCAGACGATC
TGTGAGCGACGCGCCGGCGCAAGTCGAGGGCGGTGGCTTGGCTTCCCTGGAATGGGGGACGTCTTAGGACTGCGCCTGCGCGGGGCGCCG
GGCCCTGGGCGGGGCCTTCCCGGCTGACGGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCG
TCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAGCAGTGTGTGGATTACACTATCACTGGAAAAA
TACGAATTGAGAAGAAGGAAAAGACTGGAAGATGCAGACCTTGGTTCCTGTTAGTGGAAACACTGTAAGGTCCCAGAAATGGAAAAGAAA
ATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAG
CCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAG
ACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGT
GGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTAT
GGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTG
ACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCG
GTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTG
GAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCT
GACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAGTTTCTCCATCCCCTACCTAACAGCATTGGGTGATCTGCTCGGG
ACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGATCGAGATGGAGATGTTGGAGACTAATAAATTCTACAAACTGCT
CTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTTTTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAA
TCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAAGGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTT
TTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCAGCTCTGAAATTAATTAGGAAAGAATATAGGATGTTTACAGTGA
ATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAATTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCT
TTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAAGAGTGCCCAACCAAGCTTTGAATCGTATTAACAATGCCCACCT
CTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGACCTAAATATGTTTTGCTGAGCATAAGATAAACTCACTTTTACC
TCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTGCAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTGATCTTGA
GAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGTTGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAA
CAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAATGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAG
AACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAATATCAGCAATATAGAGTTATTCTTAAACACATTCTATTAACAT
GTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACTATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTT
TGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTGATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCAAGTGATT
CTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCACAACGCCCAGCTAATTTGTTACCTACACTCTAATTAATAATTAA
TAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAGGAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAA
GCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAATTATTGTTCATGCTTAAACATATCCATTTGTACAGGCTTATTT
CTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTCTAAAACTCTGGCCTATATTCTAAACACTTGACCAACACCTTAG
TTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTAAAATTCAATCTCTCAAGACCGTTAGATATTTAATAATTTAAGC
TGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAAGTTGTAACTTTGTGTTATTATATAAATATTAGGTTGTTTATAA
ATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGACTGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAAACTTCAA
TTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACTGAACTAATTATAGAATTTCTCCTTTGGAGAGTTATAATGTTAC
ATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAATATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCATGAATAT
CTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTGTAAGATTCATAAACATTTACATTTCCCAATGATTTCTATTTTG
ATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATCAACAACTTTATTATATTACACATTCCAGTGCACAAACACACAA
TATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGATATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAATTCAGAG
AACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGAAGTCCCTAACATCCAGGTTTTCATAATGCCAGTACTCTTTCTA
TGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATTCACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTA
CAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCCGTTTATTATATCCTGATGGTGAGTATTGCCAGCTCTAAATTAT
TCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAAATAAAGAACAATGCCTTAATTTGTAAAATCTATCATTGCTACC

>68924_68924_3_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000355680_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_4_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000397637_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=4393nt_BP=1608nt
GCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGA
ACTCAGCGGAGAAACGCGATTGAGGTAGGTGTCCTGATGGGCAGCTCAGATGGCTGGACTGCACGTAAGGAAGGACAGGCCAGGTGAGGC
GTCCTCGCACTGCGTGTGCGTCGCTGGCGGACAGAGGCCTCCGCCCCCTTTTGGGACCTCCGAGCGCCTTCGCGATCTCAGCCACTTTCC
CTGGCGTCCAAACGGGAGCTCGGTCCCCGTCACACCCTTCCCTGCGTGCCGCACCCCTTCCCGGCCACTCCCGCCGTCCAGCGCCTTCTA
CGGCCACGCCCACCCCACCACCATCTCTGTCACGCCCTTCGCGGCCACGCCCACCTGCCTGGCGGCCCCTGCCCCGAAGCTCGCGGCGCT
GTCCCAGCCTGACCCTCTCGTGCCCCTGCGTCCACGCGTGGCCCTCTCGCTTCCTGCCCCCTTCTCACCCCCCTTCACTGGCCACCTGTT
CCAACCCTCCATGATCCTGTTCCTCCCGAGGGCATCTTAGGAGGGCAGGGTCCTGCGCGCACTGCGGCCTCCACTCCGACCCCGTCCCAG
TTTGGACCCAGGTCTTCCAATGAAAATATAATTATGCAAATCAGTAAGCATTTGTAACTACGAATATCACAAAAATAAGCTTCAAGTCTG
GATTTAGAAGTGAAGCATGCATTTTAAACAAAGAATTGCTATGCAATTTTAAAAACACATTGATCCCAGAGCAGTGTGTGGATTACACTA
TCACTGGAAAAATACGAATTGAGAAGAAGGAAAAGACTGGAAGATGCAGACCTTGGTTCCTGTTAGTGGAAACACTGTAAGGTCCCAGAA
ATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCG
CAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCT
GCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGT
GCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTAC
TTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAAT
AAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGA
GCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTAC
CAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGGTATTTACCTTG
CTGTGGATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAGTTTCTCCATCCCCTACCTAACAGCATTGGGT
GATCTGCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGATCGAGATGGAGATGTTGGAGACTAATAAATT
CTACAAACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTTTTTCAAAACTCTTAAATCAGTAGTTTGACTT
TTGCCAGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAAGGAATTTGTGTCAAAACCAGAATGAAGAGTA
TTCGTGCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCAGCTCTGAAATTAATTAGGAAAGAATATAGGA
TGTTTACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAATTTGTAATGCAGGATTAGAAGAAGCAGAGCT
CTAGTTTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAAGAGTGCCCAACCAAGCTTTGAATCGTATTAA
CAATGCCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGACCTAAATATGTTTTGCTGAGCATAAGATAAA
CTCACTTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTGCAAGTTCTTGTCAGGCTAATCTTTAAACATT
GAGTGATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGTTGGAAAAATGTTGATGTGTTTTAAAAAATGT
AATCTTCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAATGTGTGTGTGTGTGTGTGTGAGAGAGAGAGA
CTTTTGATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAATATCAGCAATATAGAGTTATTCTTAAACACA
TTCTATTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACTATTTGTTACCTATATTCTTTTTTTTTTTTTT
TTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTGATCTCGGCTCACTGCTACCTCCACCTCCTGG
ATTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCACAACGCCCAGCTAATTTGTTACCTACACTCTA
ATTAATAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAGGAGATTTAAAATGAGCAAGTGATTCATTTGC
TCTTTTAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAATTATTGTTCATGCTTAAACATATCCATTTGT
ACAGGCTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTCTAAAACTCTGGCCTATATTCTAAACACTTGA
CCAACACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTAAAATTCAATCTCTCAAGACCGTTAGATATTT
AATAATTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAAGTTGTAACTTTGTGTTATTATATAAATATTA
GGTTGTTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGACTGTGGTTTAGAGTTATATATTTTTGCTTATT
TTTAAACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACTGAACTAATTATAGAATTTCTCCTTTGGAGAG
TTATAATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAATATTTAGCTGCAAAGATTTTTTACTTAAAAAA
ATCCATGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTGTAAGATTCATAAACATTTACATTTCCCAATG
ATTTCTATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATCAACAACTTTATTATATTACACATTCCAGTGC
ACAAACACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGATATTCCTATCTCTATTTTACAGCAGAGGAAAC
CGAAATTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGAAGTCCCTAACATCCAGGTTTTCATAATGCCA
GTACTCTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATTCACTGAGAGGAAGCCAACTGCAAAAATAGGA
TTTTTAAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCCGTTTATTATATCCTGATGGTGAGTATTGCCA
GCTCTAAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAAATAAAGAACAATGCCTTAATTTGTAAAATCT

>68924_68924_4_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000397637_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_5_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000397638_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3644nt_BP=859nt
CGGGCCCTGGGCGGGGCCTTCCCGGCTGACGGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGAC
CGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAG
TTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGA
GGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTT
GAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAA
CCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCA
CTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCT
GGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGAT
GGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCC
CGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCTGACTGGATGGTCCATCA
CTTCTGGAGGAAAGGAAAGGACCCGGATAGTTTCTCCATCCCCTACCTAACAGCATTGGGTGATCTGCTCGGGACAGCTCTGTTAGCCTT
AAGTTTTCATTTTCTTTGGCTTATTGGAGATCGAGATGGAGATGTTGGAGACTAATAAATTCTACAAACTGCTCTCAAGTTACCAAGGAA
GAAAATACACGACAACCACTTATGGCTCTTTTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAATCTTCAGTTGGCCCTGA
TTCAATTAAATGGCCTTAATTTTTTTTTAAGGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTTTTCATAGAATAAATGAT
AATTTGACATAGACATAGATATAAGTTCCAGCTCTGAAATTAATTAGGAAAGAATATAGGATGTTTACAGTGAATAATTTTAAAACCACA
AACATAGCAGAAATGTACTTTATTATTAAATTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCTTTCTTGTCTCACAGATG
TGCTGTATCCCAGGCATACTATAAAACGAAGAGTGCCCAACCAAGCTTTGAATCGTATTAACAATGCCCACCTCTATGCTAGCTGAGGAT
AAATTTACCAGTTGCTCATATTTAAACTGACCTAAATATGTTTTGCTGAGCATAAGATAAACTCACTTTTACCTCCATCTAAAATTATCC
TGTTCTGATGCCAATTCAATTTCAGCTCTGCAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTGATCTTGAGAGATTGTTAATGAAAG
CAGTGAGTCATTTTTTGATGATTGATTTGTTGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAACAGAATATAACCTGAGA
TGCATTTGTAGAGACAAGACGGTACGAGAATGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAGAACTAAATCTTGGATTG
CTGATAGCAAAGATCATAGTGCTGTTGGAATATCAGCAATATAGAGTTATTCTTAAACACATTCTATTAACATGTTTTTGTCATTGGGTC
CAAAAATTTTGCTGCTGACCAGAATTTACTATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCT
CTGTCGCCCAGGCTGGAATGCAGTGGTGTGATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCAAGTGATTCTCCTGCCTCAGCCTCC
CGAGTAGCTGGGATTACAGGAATGCGCCACAACGCCCAGCTAATTTGTTACCTACACTCTAATTAATAATTAATAATTTCTTATTTTAAA
AAGTAGTACTATTTAATATAATCAAGATAGGAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAAGCCCGTTGACTTACGCT
TTTAAAAAAGAAGTTGGTGGGTTACCTCAATTATTGTTCATGCTTAAACATATCCATTTGTACAGGCTTATTTCTACGTGGGACCCAATC
ATATATACTATATTTCTCAAATAATTTTTCTAAAACTCTGGCCTATATTCTAAACACTTGACCAACACCTTAGTTATTGAATAGGTAACC
ATTTTTAAAGTACATGTGGTTCATTTTTTAAAATTCAATCTCTCAAGACCGTTAGATATTTAATAATTTAAGCTGATAAGGGTATCAAAA
TGCACATTAACTTTGATCATCATGATTTAAGTTGTAACTTTGTGTTATTATATAAATATTAGGTTGTTTATAAATATATTGCAGAAAGTA
TTCTTGTTAAGCTCTTTTAAATGAGGGGACTGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAAACTTCAATTATTCCATTCTTCTGC
CTTATAATAAAACTTTTAAGGCAGAGAACTGAACTAATTATAGAATTTCTCCTTTGGAGAGTTATAATGTTACATAGTGAACATTCTTAT
AAAAGAAAGAATAAGTTTAAGTTGATGAATATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCATGAATATCTTTGATTTTATTATAA
AGCATTTGTAAATTATTTGCATTTGAGCTGTAAGATTCATAAACATTTACATTTCCCAATGATTTCTATTTTGATTTTTAAAAAATATAC
AGGGCAAGCTACATTTTTAAAGCATTAATCAACAACTTTATTATATTACACATTCCAGTGCACAAACACACAATATCATTTAATACTCAC
AGTAGTACCTGTGAAATATATCAGATGGATATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAATTCAGAGAACTTACATTTCTAAGG
TTGTACAGCTGCAAAATGACCAAATTGTGAAGTCCCTAACATCCAGGTTTTCATAATGCCAGTACTCTTTCTATGACATGTTTATGACCC
TCCAAATGTACCAAAACTACCTAACTAATTCACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTACAATAGAGTATTACTAC
ATTTTATGGATTTCAGACAAAGAAACCTCCGTTTATTATATCCTGATGGTGAGTATTGCCAGCTCTAAATTATTCATATTTCTAAGACCA
AGGAAAATATAGGTAAATGAAAATTTTGAAATAAAGAACAATGCCTTAATTTGTAAAATCTATCATTGCTACCACCCTGCCCAGGTCTGG

>68924_68924_5_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000397638_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_6_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000440086_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3578nt_BP=793nt
GTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGACGCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGA
AAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGG
AGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCAC
CGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGG
CTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGACCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGG
CAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGA
ATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGT
GTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGCTTTGCTGACATCATCACCGTGTACCAGCA
GAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTG
GATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAGTTTCTCCATCCCCTACCTAACAGCATTGGGTGATCT
GCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGATCGAGATGGAGATGTTGGAGACTAATAAATTCTACA
AACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTTTTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCC
AGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAAGGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGT
GCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCAGCTCTGAAATTAATTAGGAAAGAATATAGGATGTTT
ACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAATTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGT
TTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAAGAGTGCCCAACCAAGCTTTGAATCGTATTAACAATG
CCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGACCTAAATATGTTTTGCTGAGCATAAGATAAACTCAC
TTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTGCAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTG
ATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGTTGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCT
TCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAATGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTT
GATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAATATCAGCAATATAGAGTTATTCTTAAACACATTCTA
TTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACTATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTT
TTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTGATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCA
AGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCACAACGCCCAGCTAATTTGTTACCTACACTCTAATTAA
TAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAGGAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTT
TAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAATTATTGTTCATGCTTAAACATATCCATTTGTACAGG
CTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTCTAAAACTCTGGCCTATATTCTAAACACTTGACCAAC
ACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTAAAATTCAATCTCTCAAGACCGTTAGATATTTAATAA
TTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAAGTTGTAACTTTGTGTTATTATATAAATATTAGGTTG
TTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGACTGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAA
ACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACTGAACTAATTATAGAATTTCTCCTTTGGAGAGTTATA
ATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAATATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCA
TGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTGTAAGATTCATAAACATTTACATTTCCCAATGATTTC
TATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATCAACAACTTTATTATATTACACATTCCAGTGCACAAA
CACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGATATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAA
TTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGAAGTCCCTAACATCCAGGTTTTCATAATGCCAGTACT
CTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATTCACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTT
AAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCCGTTTATTATATCCTGATGGTGAGTATTGCCAGCTCT
AAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAAATAAAGAACAATGCCTTAATTTGTAAAATCTATCAT

>68924_68924_6_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000440086_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_7_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000451211_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3614nt_BP=829nt
GGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGAC
GCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGC
AACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCC
AGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACA
AACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGA
CCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAAC
AACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAG
TCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCA
GAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTG
GATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAG
TTTCTCCATCCCCTACCTAACAGCATTGGGTGATCTGCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGA
TCGAGATGGAGATGTTGGAGACTAATAAATTCTACAAACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTT
TTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAA
GGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCA
GCTCTGAAATTAATTAGGAAAGAATATAGGATGTTTACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAA
TTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAA
GAGTGCCCAACCAAGCTTTGAATCGTATTAACAATGCCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGA
CCTAAATATGTTTTGCTGAGCATAAGATAAACTCACTTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTG
CAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTGATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGT
TGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAA
TGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAA
TATCAGCAATATAGAGTTATTCTTAAACACATTCTATTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACT
ATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTG
ATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCAC
AACGCCCAGCTAATTTGTTACCTACACTCTAATTAATAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAG
GAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAA
TTATTGTTCATGCTTAAACATATCCATTTGTACAGGCTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTC
TAAAACTCTGGCCTATATTCTAAACACTTGACCAACACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTA
AAATTCAATCTCTCAAGACCGTTAGATATTTAATAATTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAA
GTTGTAACTTTGTGTTATTATATAAATATTAGGTTGTTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGAC
TGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAAACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACT
GAACTAATTATAGAATTTCTCCTTTGGAGAGTTATAATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAAT
ATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCATGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTG
TAAGATTCATAAACATTTACATTTCCCAATGATTTCTATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATC
AACAACTTTATTATATTACACATTCCAGTGCACAAACACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGAT
ATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAATTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGA
AGTCCCTAACATCCAGGTTTTCATAATGCCAGTACTCTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATT
CACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCC
GTTTATTATATCCTGATGGTGAGTATTGCCAGCTCTAAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAA
ATAAAGAACAATGCCTTAATTTGTAAAATCTATCATTGCTACCACCCTGCCCAGGTCTGGCCATTTGCCATAAATGCTGGTAAATAAATA

>68924_68924_7_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000451211_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------
>68924_68924_8_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000458387_SLC41A2_chr12_105199115_ENST00000258538_length(transcript)=3614nt_BP=829nt
GGCCTGCGTGCACTGCGCTTGCGCGGGTTGAGGGCGGTGGCTCAGGCTCCTGGAAAGGACCGTCCACCCCTCCGCGCTGGCGGTGTGGAC
GCGGAACTCAGCGGAGAAACGCGATTGAGAAATGGAAAAGAAAATGAAATAAATCAGCAGTTATGAGGCAGAGCCTAAGAGAACTATGGC
AACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCCGGTCTCCTGCAGGAGGGAGTACAGCC
AGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAGACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACA
AACCACTGCAGATTGGTGGTGGGGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGA
CCCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATGTTGGCAGACCAGCCACGAAC
AACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGATAAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAG
TCTCTTCTGTGCACACTATGCGCGGCCTAGAGCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCA
GAACGGCTTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTGCTGGTGTCTGAGTG
GATGGGGACCTGCCTGCTGGTATTTACCTTGCTGTGGATTGCTGACTGGATGGTCCATCACTTCTGGAGGAAAGGAAAGGACCCGGATAG
TTTCTCCATCCCCTACCTAACAGCATTGGGTGATCTGCTCGGGACAGCTCTGTTAGCCTTAAGTTTTCATTTTCTTTGGCTTATTGGAGA
TCGAGATGGAGATGTTGGAGACTAATAAATTCTACAAACTGCTCTCAAGTTACCAAGGAAGAAAATACACGACAACCACTTATGGCTCTT
TTTCAAAACTCTTAAATCAGTAGTTTGACTTTTGCCAGGGTAATCTTCAGTTGGCCCTGATTCAATTAAATGGCCTTAATTTTTTTTTAA
GGAATTTGTGTCAAAACCAGAATGAAGAGTATTCGTGCTGCTTTTCATAGAATAAATGATAATTTGACATAGACATAGATATAAGTTCCA
GCTCTGAAATTAATTAGGAAAGAATATAGGATGTTTACAGTGAATAATTTTAAAACCACAAACATAGCAGAAATGTACTTTATTATTAAA
TTTGTAATGCAGGATTAGAAGAAGCAGAGCTCTAGTTTAGCCTTTCTTGTCTCACAGATGTGCTGTATCCCAGGCATACTATAAAACGAA
GAGTGCCCAACCAAGCTTTGAATCGTATTAACAATGCCCACCTCTATGCTAGCTGAGGATAAATTTACCAGTTGCTCATATTTAAACTGA
CCTAAATATGTTTTGCTGAGCATAAGATAAACTCACTTTTACCTCCATCTAAAATTATCCTGTTCTGATGCCAATTCAATTTCAGCTCTG
CAAGTTCTTGTCAGGCTAATCTTTAAACATTGAGTGATCTTGAGAGATTGTTAATGAAAGCAGTGAGTCATTTTTTGATGATTGATTTGT
TGGAAAAATGTTGATGTGTTTTAAAAAATGTAATCTTCAAAAACAGAATATAACCTGAGATGCATTTGTAGAGACAAGACGGTACGAGAA
TGTGTGTGTGTGTGTGTGTGAGAGAGAGAGACTTTTGATGAAGAACTAAATCTTGGATTGCTGATAGCAAAGATCATAGTGCTGTTGGAA
TATCAGCAATATAGAGTTATTCTTAAACACATTCTATTAACATGTTTTTGTCATTGGGTCCAAAAATTTTGCTGCTGACCAGAATTTACT
ATTTGTTACCTATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGTG
ATCTCGGCTCACTGCTACCTCCACCTCCTGGATTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGCGCCAC
AACGCCCAGCTAATTTGTTACCTACACTCTAATTAATAATTAATAATTTCTTATTTTAAAAAGTAGTACTATTTAATATAATCAAGATAG
GAGATTTAAAATGAGCAAGTGATTCATTTGCTCTTTTAAAGAAGCCCGTTGACTTACGCTTTTAAAAAAGAAGTTGGTGGGTTACCTCAA
TTATTGTTCATGCTTAAACATATCCATTTGTACAGGCTTATTTCTACGTGGGACCCAATCATATATACTATATTTCTCAAATAATTTTTC
TAAAACTCTGGCCTATATTCTAAACACTTGACCAACACCTTAGTTATTGAATAGGTAACCATTTTTAAAGTACATGTGGTTCATTTTTTA
AAATTCAATCTCTCAAGACCGTTAGATATTTAATAATTTAAGCTGATAAGGGTATCAAAATGCACATTAACTTTGATCATCATGATTTAA
GTTGTAACTTTGTGTTATTATATAAATATTAGGTTGTTTATAAATATATTGCAGAAAGTATTCTTGTTAAGCTCTTTTAAATGAGGGGAC
TGTGGTTTAGAGTTATATATTTTTGCTTATTTTTAAACTTCAATTATTCCATTCTTCTGCCTTATAATAAAACTTTTAAGGCAGAGAACT
GAACTAATTATAGAATTTCTCCTTTGGAGAGTTATAATGTTACATAGTGAACATTCTTATAAAAGAAAGAATAAGTTTAAGTTGATGAAT
ATTTAGCTGCAAAGATTTTTTACTTAAAAAAATCCATGAATATCTTTGATTTTATTATAAAGCATTTGTAAATTATTTGCATTTGAGCTG
TAAGATTCATAAACATTTACATTTCCCAATGATTTCTATTTTGATTTTTAAAAAATATACAGGGCAAGCTACATTTTTAAAGCATTAATC
AACAACTTTATTATATTACACATTCCAGTGCACAAACACACAATATCATTTAATACTCACAGTAGTACCTGTGAAATATATCAGATGGAT
ATTCCTATCTCTATTTTACAGCAGAGGAAACCGAAATTCAGAGAACTTACATTTCTAAGGTTGTACAGCTGCAAAATGACCAAATTGTGA
AGTCCCTAACATCCAGGTTTTCATAATGCCAGTACTCTTTCTATGACATGTTTATGACCCTCCAAATGTACCAAAACTACCTAACTAATT
CACTGAGAGGAAGCCAACTGCAAAAATAGGATTTTTAAAAGTACAATAGAGTATTACTACATTTTATGGATTTCAGACAAAGAAACCTCC
GTTTATTATATCCTGATGGTGAGTATTGCCAGCTCTAAATTATTCATATTTCTAAGACCAAGGAAAATATAGGTAAATGAAAATTTTGAA
ATAAAGAACAATGCCTTAATTTGTAAAATCTATCATTGCTACCACCCTGCCCAGGTCTGGCCATTTGCCATAAATGCTGGTAAATAAATA

>68924_68924_8_PRMT2-SLC41A2_PRMT2_chr21_48069651_ENST00000458387_SLC41A2_chr12_105199115_ENST00000258538_length(amino acids)=279AA_BP=218
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRMT2-SLC41A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePRMT2chr21:48069651chr12:105199115ENST00000334494+6783_207218.0285.0RB1
HgenePRMT2chr21:48069651chr12:105199115ENST00000355680+71283_207218.0434.0RB1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397637+61183_207218.0434.0RB1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397638+61183_207218.0434.0RB1
HgenePRMT2chr21:48069651chr12:105199115ENST00000440086+6983_207218.0332.0RB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePRMT2chr21:48069651chr12:105199115ENST00000334494+67133_275218.0285.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000334494+671_277218.0285.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000355680+712133_275218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000355680+7121_277218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397637+611133_275218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397637+6111_277218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397638+611133_275218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000397638+6111_277218.0434.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000440086+69133_275218.0332.0ESR1
HgenePRMT2chr21:48069651chr12:105199115ENST00000440086+691_277218.0332.0ESR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRMT2-SLC41A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRMT2-SLC41A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource