|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PRMT3-C10orf112 (FusionGDB2 ID:68927) |
Fusion Gene Summary for PRMT3-C10orf112 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRMT3-C10orf112 | Fusion gene ID: 68927 | Hgene | Tgene | Gene symbol | PRMT3 | C10orf112 | Gene ID | 10196 | 340895 |
| Gene name | protein arginine methyltransferase 3 | MAM and LDL receptor class A domain containing 1 | |
| Synonyms | HRMT1L3 | C10orf112|DIET1|bA265G8.2 | |
| Cytomap | 11p15.1 | 10p12.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein arginine N-methyltransferase 3HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | MAM and LDL-receptor class A domain-containing protein 1MAM and LDL-receptor class A domain-containing protein C10orf112novel MAM domain containing protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000331079, ENST00000437750, | ENST00000455457, ENST00000492202, ENST00000454679, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 5 X 4=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRMT3 [Title/Abstract] AND C10orf112 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PRMT3(20515800)-C10orf112(19676457), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRMT3 | GO:0031397 | negative regulation of protein ubiquitination | 18573314 |
| Fusion gene breakpoints across PRMT3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across C10orf112 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-FS-A4F4-06A | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
Top |
Fusion Gene ORF analysis for PRMT3-C10orf112 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000331079 | ENST00000455457 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| 5CDS-intron | ENST00000331079 | ENST00000492202 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| 5CDS-intron | ENST00000437750 | ENST00000455457 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| 5CDS-intron | ENST00000437750 | ENST00000492202 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| In-frame | ENST00000331079 | ENST00000454679 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| In-frame | ENST00000437750 | ENST00000454679 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000331079 | PRMT3 | chr11 | 20515800 | - | ENST00000454679 | C10orf112 | chr10 | 19676457 | + | 4035 | 1703 | 73 | 3795 | 1240 |
| ENST00000437750 | PRMT3 | chr11 | 20515800 | - | ENST00000454679 | C10orf112 | chr10 | 19676457 | + | 3663 | 1331 | 31 | 3423 | 1130 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000331079 | ENST00000454679 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + | 0.000378131 | 0.99962187 |
| ENST00000437750 | ENST00000454679 | PRMT3 | chr11 | 20515800 | - | C10orf112 | chr10 | 19676457 | + | 0.000381672 | 0.9996183 |
Top |
Fusion Genomic Features for PRMT3-C10orf112 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for PRMT3-C10orf112 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:20515800/chr10:19676457) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRMT3 | chr11:20515800 | chr10:19676457 | ENST00000331079 | - | 15 | 16 | 48_71 | 495 | 532.0 | Zinc finger | Note=C2H2-type |
| Hgene | PRMT3 | chr11:20515800 | chr10:19676457 | ENST00000437750 | - | 13 | 14 | 48_71 | 433 | 470.0 | Zinc finger | Note=C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRMT3 | chr11:20515800 | chr10:19676457 | ENST00000331079 | - | 15 | 16 | 217_531 | 495 | 532.0 | Domain | SAM-dependent MTase PRMT-type |
| Hgene | PRMT3 | chr11:20515800 | chr10:19676457 | ENST00000437750 | - | 13 | 14 | 217_531 | 433 | 470.0 | Domain | SAM-dependent MTase PRMT-type |
Top |
Fusion Gene Sequence for PRMT3-C10orf112 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >68927_68927_1_PRMT3-C10orf112_PRMT3_chr11_20515800_ENST00000331079_C10orf112_chr10_19676457_ENST00000454679_length(transcript)=4035nt_BP=1703nt ACGTGACCCGCACGGCGCCTCGAGGCCGGAAGCGATTGCGAGCCAGCGCGCGCGCTTCGGCGTTCCCGGCGGTCTGCGAAGTTTCCGGAG CCCGGGTCCCGCCGCGGGTTCGCGCTTGTGCTCGCGCTCGTTCCTGGAGTCGGCGGCCGCTGCGCGCGCTCGTTGCCCAACCCGGTCCCC GCCCCCAGACACGCCGGGCTCTCGGGGCACCACAGCCATGTGCTCGTTAGCGTCAGGCGCTACCGGCGGCCGGGGCGCTGTGGAGAATGA GGAGGACCTGCCAGAACTGTCGGACAGCGGGGACGAGGCCGCCTGGGAGGATGAGGACGATGCAGATCTCCCCCACGGCAAGCAGCAGAC CCCCTGCCTGTTCTGTAACAGGTTATTCACATCTGCTGAAGAAACATTTTCACACTGTAAGTCTGAGCATCAGTTTAATATTGACAGCAT GGTTCATAAACATGGACTTGAATTTTATGGATACATTAAGCTAATAAATTTTATTAGACTTAAGAATCCTACAGTTGAGTACATGAATTC CATATACAACCCAGTGCCTTGGGAGAAAGAAGAGTATTTGAAGCCAGTATTAGAAGATGACCTTTTACTTCAATTTGATGTAGAAGATCT TTATGAACCGGTGTCAGTACCCTTCTCATACCCCAATGGACTCAGTGAAAATACATCTGTTGTTGAAAAATTGAAACATATGGAAGCCAG GGCACTGTCTGCTGAAGCCGCATTGGCCAGAGCACGTGAGGATCTGCAAAAAATGAAACAATTTGCTCAGGATTTTGTGATGCACACAGA TGTCAGAACCTGCTCGTCATCTACTAGTGTCATTGCGGACCTCCAGGAGGATGAGGATGGTGTTTATTTCAGCTCATACGGGCATTATGG GATACATGAAGAAATGCTAAAGGACAAAATACGAACAGAAAGCTACCGAGATTTCATATACCAAAATCCACATATCTTCAAAGACAAGGT AGTTTTGGATGTTGGGTGTGGAACTGGAATTCTCTCTATGTTTGCTGCTAAAGCTGGGGCGAAGAAGGTTCTTGGAGTTGATCAATCTGA AATACTTTACCAGGCAATGGATATTATAAGACTAAATAAACTTGAAGATACTATTACACTAATTAAAGGAAAGATTGAAGAAGTTCATCT TCCTGTAGAAAAAGTAGATGTTATCATATCTGAGTGGATGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAA GAACAAATACTTGGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGA TAGAATTGCTTTTTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGA TCCGAAGACTCTTATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTT TACCCTGAAAATCACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGT GTTCTCTACGGGCCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTTTCTG CCCACTTGGCTATAGGGAATGTCATAATGGAAAATGCTATAGGCTGGAACAAAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGA TGAAAATGAGTGTGGTAGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTGGCAAAACTCCCAGGCTGACAACTTTGATTGGGTTTTAGG GGTTGGCTCTCATCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAATGAAAATGCTATCTTGTTGATGCGACGGCATAAATATCC CATCAGATCAGTTAATCTGCATACTGTGAAGCACGTGCTAAAAGCACAGACAGTTGGAAATTGTTCTGTCAGCAAGCTAGAGGCGAGGCT ATTAGATTTTCTTTCTGTTCCAAATGAAAATACTTTTGGCAGCTCAGATCATACGAATTGGCACTTCATGTATCTGGAAGCTACTGCAGT GGGCCTTCGGGGTGACAAAGCACACTTCAGGAGTACCATGTGGCGAGAATCCAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATC TGCAAAGGCCACAGGATCCATTCAGATTCTCATCAAGCGGGGGCGGAGGAGAAGGCGGGCTCCCAATCCGGTTCTATCCGGTTCTCCCAC CATCCCCCGCCAGGGGTCTCAGCAGCTCGGAGGGTGGAGGGGCGGCAGCGCCAGGCACCGCGCACGCGCCTTTCCGGAGCCAGAATGCCC AAGAGGAAGGTCAGCTCTGCTGAAGGGGCCGCCACAGGAAAAGCCTAACAGGAGGTCAGCGCTGTTGTCAGTGGGAGAGATCTCTGAGCT TTGTCCGGAAATCACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATCCCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAG GTCTGATGAAGCTCACTGTGCACATTATACAAGCACAACAGGAAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAG TCTTACTCAAGACTCTGAGGATGACTTGGACTGGGCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCC AGGTAGTGGTCAGCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGGATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGC AAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTCTACATGATTGATCCCAGGAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATC GGGGCTAAACATCCTGGTGTGGTCAGTGATTGGAAATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTT TAAGGTGGCATTTGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGCTCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGG AGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCTTGTATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATG TGATGGACATGAAGACTGCATAGATGGATCTGATGAAATGGATTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCC GTGCTCTACAGACGAGTGTATACCTTCCCTCCTGCTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAA CAAAAGCTGTTCTAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTATCCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCAT GGATTTCCAGCTTGATGAGTCCAGCTGCTCCGATACATGGACTCTCCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGC AGTCTTGTGTTTTCTTGCAAACAGAAAGGTACCAATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAA CTGGAGCAACCCAGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCCATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTC ACATCATCTCAAATAGCAGCATCGAGACCAAGTCTGATCCAACATGTGTAGTTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACT CATCTTCTACAATGGTAAAAAGAGAAAGGATTGTAAATGCCAGTGTAATTATAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAA >68927_68927_1_PRMT3-C10orf112_PRMT3_chr11_20515800_ENST00000331079_C10orf112_chr10_19676457_ENST00000454679_length(amino acids)=1240AA_BP=543 MRSFRSPGPAAGSRLCSRSFLESAAAARARCPTRSPPPDTPGSRGTTAMCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLP HGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQ FDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFS SYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGK IEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEA VVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFS VKAGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENAILLM RRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPNENTFGSSDHTNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMS FWYFVSAKATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLKGPPQEKPNRRSALLSV GEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIP DSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPL SSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLC SNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDTWTLLGIGLAFLM -------------------------------------------------------------- >68927_68927_2_PRMT3-C10orf112_PRMT3_chr11_20515800_ENST00000437750_C10orf112_chr10_19676457_ENST00000454679_length(transcript)=3663nt_BP=1331nt AGACACGCCGGGCTCTCGGGGCACCACAGCCATGTGCTCGTTAGCGTCAGGCGCTACCGGTTATTCACATCTGCTGAAGAAACATTTTCA CACTGTAAGTCTGAGCATCAGTTTAATATTGACAGCATGGTTCATAAACATGAATCCTACAGTTGAGTACATGAATTCCATATACAACCC AGTGCCTTGGGAGAAAGAAGAGTATTTGAAGCCAGTATTAGAAGATGACCTTTTACTTCAATTTGATGTAGAAGATCTTTATGAACCGGT GTCAGTACCCTTCTCATACCCCAATGGACTCAGTGAAAATACATCTGTTGTTGAAAAATTGAAACATATGGAAGCCAGGGCACTGTCTGC TGAAGCCGCATTGGCCAGAGCACGTGAGGATCTGCAAAAAATGAAACAATTTGCTCAGGATTTTGTGATGCACACAGATGTCAGAACCTG CTCGTCATCTACTAGTGTCATTGCGGACCTCCAGGAGGATGAGGATGGTGTTTATTTCAGCTCATACGGGCATTATGGGATACATGAAGA AATGCTAAAGGACAAAATACGAACAGAAAGCTACCGAGATTTCATATACCAAAATCCACATATCTTCAAAGACAAGGTAGTTTTGGATGT TGGGTGTGGAACTGGAATTCTCTCTATGTTTGCTGCTAAAGCTGGGGCGAAGAAGGTTCTTGGAGTTGATCAATCTGAAATACTTTACCA GGCAATGGATATTATAAGACTAAATAAACTTGAAGATACTATTACACTAATTAAAGGAAAGATTGAAGAAGTTCATCTTCCTGTAGAAAA AGTAGATGTTATCATATCTGAGTGGATGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTT GGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTT TTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCT TATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAAT CACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGG CCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTTTCTGCCCACTTGGCTA TAGGGAATGTCATAATGGAAAATGCTATAGGCTGGAACAAAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGATGAAAATGAGTG TGGTAGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTGGCAAAACTCCCAGGCTGACAACTTTGATTGGGTTTTAGGGGTTGGCTCTCA TCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAATGAAAATGCTATCTTGTTGATGCGACGGCATAAATATCCCATCAGATCAGT TAATCTGCATACTGTGAAGCACGTGCTAAAAGCACAGACAGTTGGAAATTGTTCTGTCAGCAAGCTAGAGGCGAGGCTATTAGATTTTCT TTCTGTTCCAAATGAAAATACTTTTGGCAGCTCAGATCATACGAATTGGCACTTCATGTATCTGGAAGCTACTGCAGTGGGCCTTCGGGG TGACAAAGCACACTTCAGGAGTACCATGTGGCGAGAATCCAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATCTGCAAAGGCCAC AGGATCCATTCAGATTCTCATCAAGCGGGGGCGGAGGAGAAGGCGGGCTCCCAATCCGGTTCTATCCGGTTCTCCCACCATCCCCCGCCA GGGGTCTCAGCAGCTCGGAGGGTGGAGGGGCGGCAGCGCCAGGCACCGCGCACGCGCCTTTCCGGAGCCAGAATGCCCAAGAGGAAGGTC AGCTCTGCTGAAGGGGCCGCCACAGGAAAAGCCTAACAGGAGGTCAGCGCTGTTGTCAGTGGGAGAGATCTCTGAGCTTTGTCCGGAAAT CACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATCCCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGC TCACTGTGCACATTATACAAGCACAACAGGAAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGA CTCTGAGGATGACTTGGACTGGGCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAGGTAGTGGTCA GCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGGATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAAT GTGTACTGTTCGGTTCTGGTTCTACATGATTGATCCCAGGAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACAT CCTGGTGTGGTCAGTGATTGGAAATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATT TGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGCTCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGGAGGTCCTGTCCC AGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCTTGTATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGA AGACTGCATAGATGGATCTGATGAAATGGATTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGA CGAGTGTATACCTTCCCTCCTGCTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACAAAAGCTGTTC TAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTATCCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCT TGATGAGTCCAGCTGCTCCGATACATGGACTCTCCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTT TCTTGCAAACAGAAAGGTACCAATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGAGCAACCC AGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCCATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAA ATAGCAGCATCGAGACCAAGTCTGATCCAACATGTGTAGTTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACTCATCTTCTACAA TGGTAAAAAGAGAAAGGATTGTAAATGCCAGTGTAATTATAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAATGTTTATATGGA >68927_68927_2_PRMT3-C10orf112_PRMT3_chr11_20515800_ENST00000437750_C10orf112_chr10_19676457_ENST00000454679_length(amino acids)=1130AA_BP=433 MCSLASGATGYSHLLKKHFHTVSLSISLILTAWFINMNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGL SENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTES YRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMG YFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHI DCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGFCPLGYRECHNGKCYR LEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLK AQTVGNCSVSKLEARLLDFLSVPNENTFGSSDHTNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSIQILIKRG RRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLKGPPQEKPNRRSALLSVGEISELCPEITDFLCRDKKC IASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGS KEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDI FIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCD GVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRK -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for PRMT3-C10orf112 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for PRMT3-C10orf112 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for PRMT3-C10orf112 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies