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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PROSC-WHSC1L1 (FusionGDB2 ID:68992) |
Fusion Gene Summary for PROSC-WHSC1L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PROSC-WHSC1L1 | Fusion gene ID: 68992 | Hgene | Tgene | Gene symbol | PROSC | WHSC1L1 | Gene ID | 11212 | 54904 |
| Gene name | pyridoxal phosphate binding protein | nuclear receptor binding SET domain protein 3 | |
| Synonyms | EPVB6D|PROSC | KMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328 | |
| Cytomap | 8p11.23 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pyridoxal phosphate homeostasis proteinPLP homeostasis proteinproline synthase co-transcribed bacterial homolog proteinproline synthetase co-transcribed bacterial homolog protein | histone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistle | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000328195, | ENST00000316985, ENST00000525081, ENST00000317025, ENST00000433384, ENST00000527502, | |
| Fusion gene scores | * DoF score | 14 X 6 X 9=756 | 14 X 10 X 9=1260 |
| # samples | 16 | 17 | |
| ** MAII score | log2(16/756*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1260*10)=-2.88981708224958 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PROSC [Title/Abstract] AND WHSC1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PROSC(37623873)-WHSC1L1(38173560), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WHSC1L1 | GO:0016571 | histone methylation | 16682010 |
| Fusion gene breakpoints across PROSC (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across WHSC1L1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A0DI | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
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Fusion Gene ORF analysis for PROSC-WHSC1L1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000328195 | ENST00000316985 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
| 5CDS-intron | ENST00000328195 | ENST00000525081 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
| In-frame | ENST00000328195 | ENST00000317025 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
| In-frame | ENST00000328195 | ENST00000433384 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
| In-frame | ENST00000328195 | ENST00000527502 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000328195 | PROSC | chr8 | 37623873 | + | ENST00000317025 | WHSC1L1 | chr8 | 38173560 | - | 8789 | 386 | 40 | 2844 | 934 |
| ENST00000328195 | PROSC | chr8 | 37623873 | + | ENST00000433384 | WHSC1L1 | chr8 | 38173560 | - | 3313 | 386 | 40 | 2697 | 885 |
| ENST00000328195 | PROSC | chr8 | 37623873 | + | ENST00000527502 | WHSC1L1 | chr8 | 38173560 | - | 2910 | 386 | 40 | 2811 | 923 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000328195 | ENST00000317025 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - | 0.000272307 | 0.99972767 |
| ENST00000328195 | ENST00000433384 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - | 0.001258025 | 0.99874204 |
| ENST00000328195 | ENST00000527502 | PROSC | chr8 | 37623873 | + | WHSC1L1 | chr8 | 38173560 | - | 0.00153681 | 0.99846315 |
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Fusion Genomic Features for PROSC-WHSC1L1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PROSC-WHSC1L1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37623873/chr8:38173560) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 1033_1069 | 0 | 646.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 1033_1069 | 618 | 1438.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 1033_1069 | 618 | 1389.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 1093_1143 | 0 | 646.0 | Domain | AWS | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 1145_1262 | 0 | 646.0 | Domain | SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 1269_1285 | 0 | 646.0 | Domain | Post-SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 270_333 | 0 | 646.0 | Domain | PWWP 1 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 960_1022 | 0 | 646.0 | Domain | PWWP 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 1093_1143 | 618 | 1438.0 | Domain | AWS | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 1145_1262 | 618 | 1438.0 | Domain | SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 1269_1285 | 618 | 1438.0 | Domain | Post-SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 960_1022 | 618 | 1438.0 | Domain | PWWP 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 1093_1143 | 618 | 1389.0 | Domain | AWS | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 1145_1262 | 618 | 1389.0 | Domain | SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 1269_1285 | 618 | 1389.0 | Domain | Post-SET | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 960_1022 | 618 | 1389.0 | Domain | PWWP 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 1321_1368 | 0 | 646.0 | Zinc finger | PHD-type 4%3B atypical | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 701_748 | 0 | 646.0 | Zinc finger | PHD-type 1 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 749_805 | 0 | 646.0 | Zinc finger | PHD-type 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000316985 | 0 | 10 | 862_955 | 0 | 646.0 | Zinc finger | PHD-type 3 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 1321_1368 | 618 | 1438.0 | Zinc finger | PHD-type 4%3B atypical | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 701_748 | 618 | 1438.0 | Zinc finger | PHD-type 1 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 749_805 | 618 | 1438.0 | Zinc finger | PHD-type 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 862_955 | 618 | 1438.0 | Zinc finger | PHD-type 3 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 1321_1368 | 618 | 1389.0 | Zinc finger | PHD-type 4%3B atypical | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 701_748 | 618 | 1389.0 | Zinc finger | PHD-type 1 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 749_805 | 618 | 1389.0 | Zinc finger | PHD-type 2 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 862_955 | 618 | 1389.0 | Zinc finger | PHD-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000317025 | 8 | 24 | 270_333 | 618 | 1438.0 | Domain | PWWP 1 | |
| Tgene | WHSC1L1 | chr8:37623873 | chr8:38173560 | ENST00000433384 | 8 | 23 | 270_333 | 618 | 1389.0 | Domain | PWWP 1 |
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Fusion Gene Sequence for PROSC-WHSC1L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >68992_68992_1_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000317025_length(transcript)=8789nt_BP=386nt CGGAACCGGAAGATGGTGTGAGCCACGGGCTGCCGGGGGCCTGGGGCTCGGCGTCGGTCCCCGGGGGATGTGGAGAGCTGGCAGCATGTC GGCCGAGCTGGGAGTCGGGTGCGCATTGCGGGCGGTGAACGAGCGCGTGCAGCAGGCTGTGGCGCGGCGGCCGCGGGATCTCCCAGCCAT CCAGCCCCGGCTAGTGGCGGTCAGCAAAACCAAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAA CTACGTTCAGGAACTGCTAGAAAAAGCATCAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACA GAAACAAAATGTCAACAAATTGATGGGTGCCAGCGAGATTTCAGATTCCTGTAAACCTCTAAAGAAAAGGAGTCGCGCCTCAACTGATGT AGAAATGACTAGTTCAGCATACAGAGACACATCTGACTCCGATTCTAGAGGACTGAGTGACCTGCAGGTAGGCTTTGGAAAGCAAGTAGA TAGCCCTTCAGCTACTGCAGATGCAGACGTTTCTGATGTGCAGTCCATGGATTCAAGTTTGTCGAGAAGAGGCACTGGAATGAGTAAGAA GGACACTGTATGTCAGATTTGTGAAAGCTCTGGTGACTCTCTGATTCCTTGTGAGGGAGAGTGCTGCAAACACTTTCACCTGGAGTGCCT GGGATTGGCATCACTTCCTGATAGCAAGTTCATCTGCATGGAATGTAAAACTGGGCAGCACCCATGTTTTTCGTGTAAAGTGTCTGGTAA AGATGTGAAGCGTTGTTCTGTTGGTGCTTGTGGGAAATTTTATCATGAAGCCTGTGTCCGCAAATTCCCCACTGCCATCTTTGAATCAAA AGGATTCCGCTGTCCTCAGCACTGCTGCTCTGCCTGCTCTATGGAGAAAGATATCCACAAAGCAAGTAAAGGCCGCATGATGAGATGTTT AAGATGTCCAGTTGCCTATCACTCTGGAGATGCTTGCATTGCGGCCGGAAGCATGTTAGTATCCTCCTACATTCTCATCTGTAGTAATCA TTCCAAACGGAGCAGTAATTCTTCTGCTGTAAATGTAGGCTTTTGTTTCGTTTGTGCCAGAGGGCTGATAGTTCAGGACCATTCAGACCC CATGTTCAGTTCATATGCCTATAAGTCCCACTACCTACTGAATGAATCAAATCGTGCTGAGTTGATGAAATTACCTATGATTCCTTCTTC GTCAGCTTCCAAAAAGAAATGTGAGAAAGGTGGAAGATTGCTCTGCTGTGAATCGTGCCCAGCTTCCTTCCACCCGGAATGCCTAAGCAT AGAAATGCCAGAAGGCTGCTGGAATTGTAATGACTGTAAAGCTGGCAAGAAACTACATTACAAGCAGATTGTTTGGGTCAAATTGGGAAA TTACAGATGGTGGCCAGCAGAGATCTGCAACCCCAGGTCTGTGCCACTGAACATCCAGGGCCTTAAACATGACTTGGGGGACTTCCCTGT ATTCTTCTTTGGTTCTCATGACTACTACTGGGTACACCAGGGCAGAGTGTTCCCTTATGTTGAAGGAGACAAAAGCTTTGCTGAAGGGCA GACTAGTATTAACAAGACCTTCAAAAAGGCACTGGAAGAAGCTGCAAAACGTTTCCAGGAATTGAAAGCACAAAGAGAAAGTAAAGAAGC CCTAGAGATTGAAAAAAACTCAAGAAAACCCCCTCCCTACAAACACATCAAAGCTAACAAAGTAATAGGAAAGGTGCAGATCCAGGTTGC TGACCTGTCAGAGATTCCCCGCTGTAACTGCAAGCCAGCTGATGAAAACCCTTGTGGCTTGGAATCGGAGTGCCTGAACAGAATGTTGCA GTATGAATGCCACCCGCAGGTGTGCCCAGCTGGAGATCGTTGTCAGAACCAGTGCTTTACAAAGAGACTATACCCTGATGCAGAGATCAT CAAAACGGAGCGGAGAGGCTGGGGCCTCAGGACCAAAAGGAGCATTAAGAAGGGTGAATTTGTAAATGAATACGTCGGTGAATTAATTGA TGAAGAAGAATGCAGATTGCGAATCAAGCGAGCCCACGAGAACAGTGTAACTAATTTTTATATGTTAACTGTTACCAAGGACCGTATAAT TGATGCCGGCCCAAAAGGAAATTATTCTCGCTTCATGAACCACAGTTGTAATCCCAACTGTGAAACACAAAAGTGGACAGTGAATGGAGA TGTTCGAGTGGGACTATTTGCTCTCTGTGATATTCCTGCAGGGATGGAGTTAACATTTAATTATAACCTAGATTGTCTGGGCAACGGCAG AACGGAGTGCCACTGTGGAGCAGATAACTGCAGTGGTTTTCTAGGAGTGCGGCCAAAGTCGGCATGTGCGTCAACAAATGAAGAGAAGGC AAAAAATGCTAAGTTAAAACAGAAGAGACGAAAGATCAAAACAGAACCAAAGCAGATGCATGAAGATTACTGTTTTCAATGTGGAGATGG TGGAGAGCTGGTCATGTGTGACAAAAAAGACTGTCCCAAAGCATACCACCTCCTATGCCTTAACCTGACTCAGCCACCATATGGAAAGTG GGAGTGTCCGTGGCATCAGTGCGATGAGTGCAGCAGTGCAGCTGTTTCCTTCTGTGAATTCTGTCCACATTCATTTTGTAAAGATCATGA AAAGGGGGCCCTGGTTCCCTCTGCACTGGAAGGCCGCCTCTGCTGCTCGGAACATGACCCCATGGCTCCTGTGTCACCAGAATACTGGAG CAAGATAAAATGTAAATGGGAATCACAAGATCATGGAGAAGAAGTAAAAGAATAAATGTGTGGTGTCCCCTCCTTTCTATTTAAGTGAAA AAAGCAAATAGATCATGCATTTAAAAAGAAGAGACTGCTACAGTGCATACAGCCTTTGCCATCGGAACTGCCTTATTAAAGCAAAAATGG GAAACCAGTTCATGCAGGCAGAAGCAGTTGGTGGTGTCTGGTTTTTGTTTGATTTGGTTGGTTTGGGATTCTTTTGTGGAGGGTTAAATT CCCTTGGTCTTTTCTTGCCTTTTATTGTGCTTCAGTGCCATTGCAGCTTGAAAAAGAAATGTTTTTGCTGTTAAAATAAGAACAAAGAGA AAAGTAAGTTTTGTTAATGAGATAAATTTAAAGTCTAAGATGTGTTCCTTGGTTGTATAAAGCAAAAGTAGCCATCATTCCTTTATTTAT TTTCATTTTTAGGAATTTCAAGAAGTGTAGTTCAATAGTCTAATCAAGTGTGTGTGTGTTTTAAGTAGGAATCTGAGAAAGCCCTCTAGG AAAGGGTATGATAAGCTTTATATACCTCTTTACTGAGCAGTAGGTAGGCTCACTTCTCTTTCCCTTCAAAATGCTTTTCATAGGCTTAGA GAAGGGCTCTATGGAAGTATTAAATCTGGCCTCTTGAAAACAATGCCTCGGTGGATTTTACCTCTGTGGTCTTAAACAAGGTGGGCTTTG TACTATGGTAACTTTACCTAGAAGGGTATATGGTGTGTTTCCTTGGTGGAAGGAAAAAAAGGAATGGATGTGCTCACTGATTTTTAAAAC GTTTTCCATTGACATGGATGGTTTGGGTTTTGGATGAAGTGCGTTTCTGTGGATATGAAGCATAGTTGGAATGGTCACTCCTATTTTCCT GACACTGATTAAGGCAGCTAAAGGGGGATGAAGGCATAAACCAAAATTTGGATCATATAAGCACCATTTTCTGTCCAATTTTATTGTAGA CCCTGGTCTTAATTGGAGAGAATTACAGGCATTTTATTTTTTGTCTCTGTTTTCCTCTCCTACTCAAACATTTCTTTTGTCATCTGACCA TTCAGTCATGTTTCCTGGTAAAACCACACAAGTGAGTTTGAATTGTATTTGAATAGATCTTTTTGGTTGAGTTCCTAATTTGGGGGGTGA AAGTAGTAGGGGCATCCCCAGGTTACATGTAAAGAATTTCTATTATTATCCAGTACTTAAGATTGCTCCCATTGAGTAAGGGGAAGAACT TCTACTTTTACAGGGTGCATAAGAGCCACACAAACACACTTCATCTTAGGAAGCACTTGGAGAAAACTCCCAAGAAAGTCAGTGTTAGCA AAAATGGTTGATGGTGATGCTTGACTCTTATAGATGCGAGTATACCAAGATGTCTGCTCACCAAACTCACTTGCTTTTAATGCTTAGGAA TATGTATATTCCAGTATTCCTTGTATGAAAATAATTAGTAATGTCAGACATTGTTGTAACACTGTACTAAGTAGAAGTCTAGGGTTAGCT TGAATGAATGTTAACTTTCTCTGTGAATTTTGACTGCTTACAATTGCTGGTACCTGGTAGCATTTATTTTCCCTCAAGTACCTAGTAACC TTATGAAGGTAGGGAGGGTAGATGCTCTACCACATTCCTTCAGCTGTATTGAGTGTTCCATTTGCTTATCAATTTAGAGCTCTTCTATGG AAAGAGGGTGAAAATCTGTTTTGTGCCTCTTTTTTTTGTATGTAAATGTGCAATTATACTGGATTTTCTCTTGTAAAAAACACTACAATT CTTTTACTGAAGCTCCTAAACTGCCATTTGCCTGACTCCAGCAATTAATTCTGCGGTGACTCATTGGGCTTCCAGTACTTCTGTTGATTA GATATGGTCCCAAAAGAAAGAGCAAAATGGAAAATGCGATCCATGTCACCAAATATAATTGCTACAAGTAACATGAAATACAGCTCACCA AAACACTAAACTTTGCTCTTGAGCAATTATATAGTTTGATGTCCTTTTAAAAAATAAGAAAAGCTAGGTTTTATCATACTAAAATTTTAT TTTGTATATGATGTTTGGTTTTTTAAACTTACTAACATAAGGATTTCCTTTAATATTCCAAATACAGTTCTTGAAACAGTATCCAACATG AAATCTTATCTCCTTGCTTTTAGACTTAGTGCTATTTACTATCTAAAGACTTTTCTATGGTAAGCCAGGGTACATCCTATATACTACAGA TACCTTAGGTTTCAGTATTTTTATGCAGCTTCTTCATTGTGTCACATTTTGTTTTCATATCTGTAACAGAGCTCTGCTGAAATTAAAAAA AAATTATGATTAATAGGATTGTTTCACCATTTCAGAAATCAGAGTAGAAAACAAAATAGCTGCCAGGTGCAGTGGCTCACACCTGTAATC CCAGCACTTTGGGAGGCCGAGGTGGGCAGATCATGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTCTGCTAA AAATACAAAAAGGAGCCGGGCATGGTGGCACATACCTGTAGTCCCAGTTTCTCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACATCAC TGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAAAAAGGTAACCATAGTTCTGAAGTCTTTGGCCATGAATGTTCTTTA ATGGTCTAAAAAGCGGTTTTAGTCATGCTGGTGCCAAGGAGTTCTCCTCACACCTCCATAGCGTCAATGTTGACCTATTTGATATATTTT TAAGTTGCAGATTATAGATGCAGAAAGAGAAAATTGTCCTTTATGTGTGCATGAGTATACATGCACTGTGCCTGTGATACACCAATGAAA TATTCCAAAAGACATTGCTCACTCATAGTCTGAAGTTGGTATTTGTTAACTTTTAAATCTATATGTGGTCAGAGTGTAAGTGGCTGGTTT TTATTCTTGTCCAACAATGAAATAACTTAAAGCAGCATGGGCTAATGGTGGTATTTTTTTTAACCACATGTTAATTTGTTGAAGGAAGAA GTGAACATAAGATTTTTGATAATCAGCCTAAAGCTTCAGAAACTGGATCAGTAAGAGCTAAAGATGAAATCCTGGGAAACTTTCTCAGGC ACTGTGCAGGGGAGGGAGGGGCTGGACCGCCACTGCTGCGAGGGAAGAATCAGAAGAGCTGCCTGTGGCTGGCTGAGAAGGGCAAGGTGG ATGGCTCTTCATTCCTGGAAGGCTGAAGCAGCCAGAGGCAGTGATTCACCTCTTTAATGTCTAATCAGGGAGAGATACAGGAGTGAGGTG GGTTTTATTTTCATTTTTGTTTTAACAAGTTCCCACTCTTATCTTAATTCTCAAAAATGATCTGGCCTCATCTATAGAACTGGCTGAGTT GGGGAATCATTTAAAATTTGGGATTTTCTGTACAAGTCAAGAACATATGTGAAAGCTAAAAAAGTAATGGAGGCAGGGGGACTGCTCCCA GCTCCCTTCTGCCATTTACACAAAATATTTGAAAACATGTCTGTAAATAACGTTGTGGAACTGAGATATTGAGTATCTAATCATGTAAAG GACCCTCAGATGGGACAGGCTATTGGACAACTTTCCTGGTTCATGAAGTGGAATTTCCTTTTTGAGTAGTTTCTTGCATGGTGTATTCCA ATAGGTCAAACCCAGACCTACTGTTTGCAAACAGGCCATCTGTAGAGAATACAATCTCTGGACTGCCCAGGACTTGTTGCTTGTCTTTCA TTTCATTTTAAATACAAAGCTCTTCCTTTAGCATTCACCTTGAAGTCAAGGTGTTGGCTGCCACATGCCATGTCCTCTTAACAAGATAAG AAAACAGTGGCTATGGAGCCCTCACAGCTGGGAAGCTGACATTCTATACTTCCATATGAGAAAAAGGACATTGGAAAGTTGCTTTATTTC TGGGCAGCGTAGACTAAAGTTACTTTTCACAAGGCTGATGCATCCAGCCTCCCCCAGTTGTCCAAGTTGGTGCAGACATGAATTGATGAA TGGAAACACTTTCCTTTGGCCTAGGGCCACCTAGAATTGGTCTCTGGTTATTTGTAAAACAAAAAGTAGAACTTGCTTCCATTTTCAGAT GGACTAGGGAATACTATAATTAGACAGCTTTGCAATGAATTAACAAATACTGAAAAGTTGGAAATGTGTATATACTGAAATCTCACCAAC TTTTACCTGGGGTGGGGTACCAGGAGAAAGGGAACCCCCTTTCTCCTGGTAAAGGGTAAGGGGGGGGATAATGTTTACCACAGGTACGAA ATAGTCACTTTAACATTGAGACCTCTGCCTCATTGAATTCAGGTTTTTTAAGTACTTGAAACTCTTCAGATTCTCCTTATTTTAGTTTCT TTTTACATTTATGAAGTAGAAAGCATTGTTTTGTAAACTGTTTTGAAAATAAATAGCCTAGTCTCTTATCCTCTTTAGCGTGGATTAAAG GTGAAGTTCTGCAAATGGGAGAGTGTTCACAGTAGATAGCTCAGATTGATTGAACACATTTGAGGAAGAGACTCCTGCATGAGATACCAG CATTTTTACAAATACTTTTTATGTACATTCTTTATTTTGTCATTTTGTCAACCCTCTCCCCAAGCACATCTTCTTTCCTTTTACTATGTC TATGTAGGGAAAAAAACAAAACAAAAAATTGCACTTACGTTACACTCCCAAAATGTGGGTAATCCGTGTCTTTCAAAAAACATTTCTGTT TTTTGTTTTGTTTTGGTCAGTCCATTGCATAAGTGACAAGTTTGGGTGCTTGTGGCACGTATGTATGAAGCGGGAGGGGGATGAGAATTG CCTGTCCTTCAGTAGGCTGTAAAAGTAATTTACATGTAAGTAAAAAGGGAAAATAGAATAGATGCCAAAGTCATTTATTCAGTCCTTAGT TTTCTTATGTGGCATTACTGCATCTGCTAGTTAGTGAGAAAGCACCCTCAGCTTTTACTGCTCCCCTCCCTGCCTGCCAACACACTTGAT GTGTGCAAACAGCCCTCAAGTATCTGTCAGATGACCTATATAAGGTATTGAATAAGGTATTCTTGTCAGTTTAGAAATGGACTGGATAAA ACTTACTTGGTTGTCATTATTTTATCTCATTTGTCCTGTTACATGCCCTATGTTAAGATAATTATATTGCCACTAATAATCAAGATGCTA AATGAGTATTACAACTGGCTAATATCATTTTTTATATACAAGGGTATGTGTATATTTGGAATTGATATGAGAAACTCATTTGTACCCATT TGAGTGATATTGCACAACAAACACAGATACCTACAGACTCCGTTTTCATTTTCTCGTGTTCTTTATGATAATGATCTTTGTAGATTGGTT ATTTCTGTACTTTATCTGTAATAAACTTTGTAGATCCTGTGAACCATTACTTTGCCTAAATCACTTGAGACTTGAGTCTTTAATAACAAA GCATCAATATTCACTAAAGTCAATCTCTTTTGAGTTTCTGTGACTTGGCTAGAAGCTCTTGACACTAAGGGATTAGTGTTAATTTTCCCT GGGGGTGTTCCACTAGGGCATTACTGTATAATGACTTGATGTTGCCACATAGACTTCAAGATATATAATATTTTGAGGATTTTGTTGATT GGCCTATGTTTTATTGCATAGTGTGAAACGTGTAAAGCTTGGTTAACCTGTATATAGATAGCTTATTGTTGACTAGTTATAGTGTATTTA GGGTTGCCTGTAATATTTAAGCTTCTTTACTGATGTGTGTGCTGGTAGGAACATATAATTTTTGTACATTATATTTACTGAGATGTTGCC TTTTTTATTTTACAAATACTTTGGAATTCCAATGTGTTTTTTGCTTCCGTGAGGATTAATTTGGAAAGGTTTTTAATGACATTCCACTGA >68992_68992_1_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000317025_length(amino acids)=934AA_BP=115 MGLGVGPRGMWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPK ILSLCPEIKWHFIGHLQKQNVNKLMGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDV QSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKF YHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVG FCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCK AGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEE AAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDR CQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIK TEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRL -------------------------------------------------------------- >68992_68992_2_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000433384_length(transcript)=3313nt_BP=386nt CGGAACCGGAAGATGGTGTGAGCCACGGGCTGCCGGGGGCCTGGGGCTCGGCGTCGGTCCCCGGGGGATGTGGAGAGCTGGCAGCATGTC GGCCGAGCTGGGAGTCGGGTGCGCATTGCGGGCGGTGAACGAGCGCGTGCAGCAGGCTGTGGCGCGGCGGCCGCGGGATCTCCCAGCCAT CCAGCCCCGGCTAGTGGCGGTCAGCAAAACCAAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAA CTACGTTCAGGAACTGCTAGAAAAAGCATCAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACA GAAACAAAATGTCAACAAATTGATGGGTGCCAGCGAGATTTCAGATTCCTGTAAACCTCTAAAGAAAAGGAGTCGCGCCTCAACTGATGT AGAAATGACTAGTTCAGCATACAGAGACACATCTGACTCCGATTCTAGAGGACTGAGTGACCTGCAGGTAGGCTTTGGAAAGCAAGTAGA TAGCCCTTCAGCTACTGCAGATGCAGACGTTTCTGATGTGCAGTCCATGGATTCAAGTTTGTCGAGAAGAGGCACTGGAATGAGTAAGAA GGACACTGTATGTCAGATTTGTGAAAGCTCTGGTGACTCTCTGATTCCTTGTGAGGGAGAGTGCTGCAAACACTTTCACCTGGAGTGCCT GGGATTGGCATCACTTCCTGATAGCAAGTTCATCTGCATGGAATGTAAAACTGGGCAGCACCCATGTTTTTCGTGTAAAGTGTCTGGTAA AGATGTGAAGCGTTGTTCTGTTGGTGCTTGTGGGAAATTTTATCATGAAGCCTGTGTCCGCAAATTCCCCACTGCCATCTTTGAATCAAA AGGATTCCGCTGTCCTCAGCACTGCTGCTCTGCCTGCTCTATGGAGAAAGATATCCACAAAGCAAGTAAAGGCCGCATGATGAGATGTTT AAGATGTCCAGTTGCCTATCACTCTGGAGATGCTTGCATTGCGGCCGGAAGCATGTTAGTATCCTCCTACATTCTCATCTGTAGTAATCA TTCCAAACGGAGCAGTAATTCTTCTGCTGTAAATGTAGGCTTTTGTTTCGTTTGTGCCAGAGGTGGAAGATTGCTCTGCTGTGAATCGTG CCCAGCTTCCTTCCACCCGGAATGCCTAAGCATAGAAATGCCAGAAGGCTGCTGGAATTGTAATGACTGTAAAGCTGGCAAGAAACTACA TTACAAGCAGATTGTTTGGGTCAAATTGGGAAATTACAGATGGTGGCCAGCAGAGATCTGCAACCCCAGGTCTGTGCCACTGAACATCCA GGGCCTTAAACATGACTTGGGGGACTTCCCTGTATTCTTCTTTGGTTCTCATGACTACTACTGGGTACACCAGGGCAGAGTGTTCCCTTA TGTTGAAGGAGACAAAAGCTTTGCTGAAGGGCAGACTAGTATTAACAAGACCTTCAAAAAGGCACTGGAAGAAGCTGCAAAACGTTTCCA GGAATTGAAAGCACAAAGAGAAAGTAAAGAAGCCCTAGAGATTGAAAAAAACTCAAGAAAACCCCCTCCCTACAAACACATCAAAGCTAA CAAAGTAATAGGAAAGGTGCAGATCCAGGTTGCTGACCTGTCAGAGATTCCCCGCTGTAACTGCAAGCCAGCTGATGAAAACCCTTGTGG CTTGGAATCGGAGTGCCTGAACAGAATGTTGCAGTATGAATGCCACCCGCAGGTGTGCCCAGCTGGAGATCGTTGTCAGAACCAGTGCTT TACAAAGAGACTATACCCTGATGCAGAGATCATCAAAACGGAGCGGAGAGGCTGGGGCCTCAGGACCAAAAGGAGCATTAAGAAGGGTGA ATTTGTAAATGAATACGTCGGTGAATTAATTGATGAAGAAGAATGCAGATTGCGAATCAAGCGAGCCCACGAGAACAGTGTAACTAATTT TTATATGTTAACTGTTACCAAGGACCGTATAATTGATGCCGGCCCAAAAGGAAATTATTCTCGCTTCATGAACCACAGTTGTAATCCCAA CTGTGAAACACAAAAGTGGACAGTGAATGGAGATGTTCGAGTGGGACTATTTGCTCTCTGTGATATTCCTGCAGGGATGGAGTTAACATT TAATTATAACCTAGATTGTCTGGGCAACGGCAGAACGGAGTGCCACTGTGGAGCAGATAACTGCAGTGGTTTTCTAGGAGTGCGGCCAAA GTCGGCATGTGCGTCAACAAATGAAGAGAAGGCAAAAAATGCTAAGTTAAAACAGAAGAGACGAAAGATCAAAACAGAACCAAAGCAGAT GCATGAAGATTACTGTTTTCAATGTGGAGATGGTGGAGAGCTGGTCATGTGTGACAAAAAAGACTGTCCCAAAGCATACCACCTCCTATG CCTTAACCTGACTCAGCCACCATATGGAAAGTGGGAGTGTCCGTGGCATCAGTGCGATGAGTGCAGCAGTGCAGCTGTTTCCTTCTGTGA ATTCTGTCCACATTCATTTTGTAAAGATCATGAAAAGGGGGCCCTGGTTCCCTCTGCACTGGAAGGCCGCCTCTGCTGCTCGGAACATGA CCCCATGGCTCCTGTGTCACCAGAATACTGGAGCAAGATAAAATGTAAATGGGAATCACAAGATCATGGAGAAGAAGTAAAAGAATAAAT GTGTGGTGTCCCCTCCTTTCTATTTAAGTGAAAAAAGCAAATAGATCATGCATTTAAAAAGAAGAGACTGCTACAGTGCATACAGCCTTT GCCATCGGAACTGCCTTATTAAAGCAAAAATGGGAAACCAGTTCATGCAGGCAGAAGCAGTTGGTGGTGTCTGGTTTTTGTTTGATTTGG TTGGTTTGGGATTCTTTTGTGGAGGGTTAAATTCCCTTGGTCTTTTCTTGCCTTTTATTGTGCTTCAGTGCCATTGCAGCTTGAAAAAGA AATGTTTTTGCTGTTAAAATAAGAACAAAGAGAAAAGTAAGTTTTGTTAATGAGATAAATTTAAAGTCTAAGATGTGTTCCTTGGTTGTA TAAAGCAAAAGTAGCCATCATTCCTTTATTTATTTTCATTTTTAGGAATTTCAAGAAGTGTAGTTCAATAGTCTAATCAAGTGTGTGTGT GTTTTAAGTAGGAATCTGAGAAAGCCCTCTAGGAAAGGGTATGATAAGCTTTATATACCTCTTTACTGAGCAGTAGGTAGGCTCACTTCT >68992_68992_2_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000433384_length(amino acids)=885AA_BP=115 MGLGVGPRGMWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPK ILSLCPEIKWHFIGHLQKQNVNKLMGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDV QSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKF YHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVG FCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFF FGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADL SEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEE ECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTE CHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWEC -------------------------------------------------------------- >68992_68992_3_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000527502_length(transcript)=2910nt_BP=386nt CGGAACCGGAAGATGGTGTGAGCCACGGGCTGCCGGGGGCCTGGGGCTCGGCGTCGGTCCCCGGGGGATGTGGAGAGCTGGCAGCATGTC GGCCGAGCTGGGAGTCGGGTGCGCATTGCGGGCGGTGAACGAGCGCGTGCAGCAGGCTGTGGCGCGGCGGCCGCGGGATCTCCCAGCCAT CCAGCCCCGGCTAGTGGCGGTCAGCAAAACCAAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAA CTACGTTCAGGAACTGCTAGAAAAAGCATCAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACA GAAACAAAATGTCAACAAATTGATGGGTGCCAGCGAGATTTCAGATTCCTGTAAACCTCTAAAGAAAAGGAGTCGCGCCTCAACTGATGT AGAAATGACTAGTTCAGCATACAGAGACACATCTGACTCCGATTCTAGAGGACTGAGTGACCTGCAGGTAGGCTTTGGAAAGCAAGTAGA TAGCCCTTCAGCTACTGCAGATGCAGACGTTTCTGATGTGCAGTCCATGGATTCAAGTTTGTCGAGAAGAGGCACTGGAATGAGTAAGAA GGACACTGTATGTCAGATTTGTGAAAGCTCTGGTGACTCTCTGATTCCTTGTGAGGGAGAGTGCTGCAAACACTTTCACCTGGAGTGCCT GGGATTGGCATCACTTCCTGATAGCAAGTTCATCTGCATGGAATGTAAAACTGGGCAGCACCCATGTTTTTCGTGTAAAGTGTCTGGTAA AGATGTGAAGCGTTGTTCTGTTGGTGCTTGTGGGAAATTTTATCATGAAGCCTGTGTCCGCAAATTCCCCACTGCCATCTTTGAATCAAA AGGATTCCGCTGTCCTCAGCACTGCTGCTCTGCCTGCTCTATGGAGAAAGATATCCACAAAGCAAGTAAAGGCCGCATGATGAGATGTTT AAGATGTCCAGTTGCCTATCACTCTGGAGATGCTTGCATTGCGGCCGGAAGCATGTTAGTATCCTCCTACATTCTCATCTGTAGTAATCA TTCCAAACGGAGCAGTAATTCTTCTGCTGTAAATGTAGGCTTTTGTTTCGTTTGTGCCAGAGGGCTGATAGTTCAGGACCATTCAGACCC CATGTTCAGTTCATATGCCTATAAGTCCCACTACCTACTGAATGAATCAAATCGTGCTGAGTTGATGAAATTACCTATGATTCCTTCTTC GTCAGCTTCCAAAAAGAAATGTGAGAAAGGTGGAAGATTGCTCTGCTGTGAATCGTGCCCAGCTTCCTTCCACCCGGAATGCCTAAGCAT AGAAATGCCAGAAGGCTGCTGGAATTGTAATGACTGTAAAGCTGGCAAGAAACTACATTACAAGCAGATTGTTTGGGTCAAATTGGGAAA TTACAGATGGTGGCCAGCAGAGATCTGCAACCCCAGGTCTGTGCCACTGAACATCCAGGGCCTTAAACATGACTTGGGGGACTTCCCTGT ATTCTTCTTTGGTTCTCATGACTACTACTGGGTACACCAGGGCAGAGTGTTCCCTTATGTTGAAGGAGACAAAAGCTTTGCTGAAGGGCA GACTAGTATTAACAAGACCTTCAAAAAGGCACTGGAAGAAGCTGCAAAACGTTTCCAGGAATTGAAAGCACAAAGAGAAAGTAAAGAAGC CCTAGAGATTGAAAAAAACTCAAGAAAACCCCCTCCCTACAAACACATCAAAGCTAACAAAGTAATAGGAAAGGTGCAGATCCAGGTTGC TGACCTGTCAGAGATTCCCCGCTGTAACTGCAAGCCAGCTGATGAAAACCCTTGTGGCTTGGAATCGGAGTGCCTGAACAGAATGTTGCA GTATGAATGCCACCCGCAGGTGTGCCCAGCTGGAGATCGTTGTCAGAACCAGTGCTTTACAAAGAGACTATACCCTGATGCAGAGATCAT CAAAACGGAGCGGAGAGGCTGGGGCCTCAGGACCAAAAGGAGCATTAAGAAGGGTGAATTTGTAAATGAATACGTCGGTGAATTAATTGA TGAAGAAGAATGCAGATTGCGAATCAAGCGAGCCCACGAGAACAGTGACCGTATAATTGATGCCGGCCCAAAAGGAAATTATTCTCGCTT CATGAACCACAGTTGTAATCCCAACTGTGAAACACAAAAGTGGACAGTGAATGGAGATGTTCGAGTGGGACTATTTGCTCTCTGTGATAT TCCTGCAGGGATGGAGTTAACATTTAATTATAACCTAGATTGTCTGGGCAACGGCAGAACGGAGTGCCACTGTGGAGCAGATAACTGCAG TGGTTTTCTAGGAGTGCGGCCAAAGTCGGCATGTGCGTCAACAAATGAAGAGAAGGCAAAAAATGCTAAGTTAAAACAGAAGAGACGAAA GATCAAAACAGAACCAAAGCAGATGCATGAAGATTACTGTTTTCAATGTGGAGATGGTGGAGAGCTGGTCATGTGTGACAAAAAAGACTG TCCCAAAGCATACCACCTCCTATGCCTTAACCTGACTCAGCCACCATATGGAAAGTGGGAGTGTCCGTGGCATCAGTGCGATGAGTGCAG CAGTGCAGCTGTTTCCTTCTGTGAATTCTGTCCACATTCATTTTGTAAAGATCATGAAAAGGGGGCCCTGGTTCCCTCTGCACTGGAAGG CCGCCTCTGCTGCTCGGAACATGACCCCATGGCTCCTGTGTCACCAGAATACTGGAGCAAGATAAAATGTAAATGGGAATCACAAGATCA TGGAGAAGAAGTAAAAGAATAAATGTGTGGTGTCCCCTCCTTTCTATTTAAGTGAAAAAAGCAAATAGATCATGCATTTAAAAAGAAGAG >68992_68992_3_PROSC-WHSC1L1_PROSC_chr8_37623873_ENST00000328195_WHSC1L1_chr8_38173560_ENST00000527502_length(amino acids)=923AA_BP=115 MGLGVGPRGMWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPK ILSLCPEIKWHFIGHLQKQNVNKLMGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDV QSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKF YHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVG FCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCK AGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEE AAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDR CQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSDRIIDAGPKGNYSRFMNHSCNPNCETQK WTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYC FQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PROSC-WHSC1L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PROSC-WHSC1L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PROSC-WHSC1L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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