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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRPF18-CACNB2 (FusionGDB2 ID:69005)

Fusion Gene Summary for PRPF18-CACNB2

check button Fusion gene summary
Fusion gene informationFusion gene name: PRPF18-CACNB2
Fusion gene ID: 69005
HgeneTgene
Gene symbol

PRPF18

CACNB2

Gene ID

8559

783

Gene namepre-mRNA processing factor 18calcium voltage-gated channel auxiliary subunit beta 2
SynonymsPRP18|hPrp18CAB2|CACNLB2|CAVB2|MYSB
Cytomap

10p13

10p12.33-p12.31

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA-splicing factor 18PRP18 homologPRP18 pre-mRNA processing factor 18 homologPRP18 pre-mRNA processing factor 18 homolog(PRPF18)voltage-dependent L-type calcium channel subunit beta-2calcium channel voltage-dependent subunit beta 2calcium channel, voltage-dependent, beta 2 subunitlambert-Eaton myasthenic syndrome antigen Bmyasthenic (Lambert-Eaton) syndrome antigen B
Modification date2020031320200322
UniProtAcc.

Q08289

Ensembl transtripts involved in fusion geneENST00000378572, ENST00000467034, 
ENST00000377315, ENST00000377319, 
ENST00000377329, ENST00000396576, 
ENST00000282343, ENST00000324631, 
ENST00000352115, ENST00000377328, 
ENST00000377331, 
Fusion gene scores* DoF score6 X 5 X 4=12015 X 16 X 3=720
# samples 616
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/720*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRPF18 [Title/Abstract] AND CACNB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRPF18(13647744)-CACNB2(18439812), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCACNB2

GO:0051928

positive regulation of calcium ion transport

1309651

TgeneCACNB2

GO:0070509

calcium ion import

1309651


check buttonFusion gene breakpoints across PRPF18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12L-01APRPF18chr10

13647744

-CACNB2chr10

18439812

+
ChimerDB4BRCATCGA-C8-A12L-01APRPF18chr10

13647744

+CACNB2chr10

18439812

+


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Fusion Gene ORF analysis for PRPF18-CACNB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000378572ENST00000467034PRPF18chr10

13647744

+CACNB2chr10

18439812

+
5CDS-intronENST00000378572ENST00000377315PRPF18chr10

13647744

+CACNB2chr10

18439812

+
5CDS-intronENST00000378572ENST00000377319PRPF18chr10

13647744

+CACNB2chr10

18439812

+
5CDS-intronENST00000378572ENST00000377329PRPF18chr10

13647744

+CACNB2chr10

18439812

+
5CDS-intronENST00000378572ENST00000396576PRPF18chr10

13647744

+CACNB2chr10

18439812

+
In-frameENST00000378572ENST00000282343PRPF18chr10

13647744

+CACNB2chr10

18439812

+
In-frameENST00000378572ENST00000324631PRPF18chr10

13647744

+CACNB2chr10

18439812

+
In-frameENST00000378572ENST00000352115PRPF18chr10

13647744

+CACNB2chr10

18439812

+
In-frameENST00000378572ENST00000377328PRPF18chr10

13647744

+CACNB2chr10

18439812

+
In-frameENST00000378572ENST00000377331PRPF18chr10

13647744

+CACNB2chr10

18439812

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378572PRPF18chr1013647744+ENST00000324631CACNB2chr1018439812+37895231602385741
ENST00000378572PRPF18chr1013647744+ENST00000377328CACNB2chr1018439812+16365231601635492
ENST00000378572PRPF18chr1013647744+ENST00000352115CACNB2chr1018439812+23145231602313718
ENST00000378572PRPF18chr1013647744+ENST00000282343CACNB2chr1018439812+37895231602385741
ENST00000378572PRPF18chr1013647744+ENST00000377331CACNB2chr1018439812+23145231602313718

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378572ENST00000324631PRPF18chr1013647744+CACNB2chr1018439812+0.0004112710.9995888
ENST00000378572ENST00000377328PRPF18chr1013647744+CACNB2chr1018439812+0.0029965860.9970034
ENST00000378572ENST00000352115PRPF18chr1013647744+CACNB2chr1018439812+0.0028483260.9971517
ENST00000378572ENST00000282343PRPF18chr1013647744+CACNB2chr1018439812+0.0004112710.9995888
ENST00000378572ENST00000377331PRPF18chr1013647744+CACNB2chr1018439812+0.0028483260.9971517

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Fusion Genomic Features for PRPF18-CACNB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRPF18chr1013647744+CACNB2chr1018439811+0.0006555420.9993444
PRPF18chr1013647744+CACNB2chr1018439811+0.0006555420.9993444

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRPF18-CACNB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:13647744/chr10:18439812)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNB2

Q08289

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCACNB2chr10:13647744chr10:18439812ENST00000282343014114_18312633.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000324631014114_18340661.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000352115014114_18340637.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000377315013114_1830613.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000377319013114_1830568.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000377329013114_1830607.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000377331014114_18312609.0DomainSH3
TgeneCACNB2chr10:13647744chr10:18439812ENST00000396576013114_1830606.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PRPF18-CACNB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69005_69005_1_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000282343_length(transcript)=3789nt_BP=523nt
CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG
GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA
GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGGAAAATAAAAAATATTTCAAGCGTAGTGAGCTCGCCAAAAAAGA
AGAGGAAGCATATTTTGAAAGATGTGGCTACAAGATACAGCCAAAAGAGGAGGACCAGAAACCATTAACTTCATCGAATCCAGTGTTAGA
ACTTGAACTGGCAGAGGAAAAATTACCTATGACGCTTTCTAGGCAAGAGGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAATCAGACT
ATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGTCATATGGAAAAGGAGC
CAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTC
CTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACA
GTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCC
TGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGA
AGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTA
CTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGCTATAGA
CATAGATGCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCACC
CCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCT
AGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGAT
ATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAA
CACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGA
TACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAG
GTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCT
GTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCC
TCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACA
GGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAA
GAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGA
CTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCG
TGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCA
GGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACG
GAATGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTG
TATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGT
TGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTC
CGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAG
AAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGC
AGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCT
TACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGCAAA
CAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCT
TTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTG
TACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCA
CCATAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCT
GTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACT
GAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAAT
TAATTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCAT
CTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGT
TAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTCTCCCACTTCAATT

>69005_69005_1_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000282343_length(amino acids)=741AA_BP=121
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRE
RGEPIRLFGETDYDAFQRLRKIEILTPEVNKSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREA
ERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQR
AKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVP
SMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQ
LVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEA
YWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGL
SRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDG

--------------------------------------------------------------
>69005_69005_2_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000324631_length(transcript)=3789nt_BP=523nt
CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG
GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA
GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGGAAAATAAAAAATATTTCAAGCGTAGTGAGCTCGCCAAAAAAGA
AGAGGAAGCATATTTTGAAAGATGTGGCTACAAGATACAGCCAAAAGAGGAGGACCAGAAACCATTAACTTCATCGAATCCAGTGTTAGA
ACTTGAACTGGCAGAGGAAAAATTACCTATGACGCTTTCTAGGCAAGAGGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAATCAGACT
ATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGTCATATGGAAAAGGAGC
CAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTC
CTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACA
GTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCC
TGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGA
AGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTA
CTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGCTATAGA
CATAGATGCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCACC
CCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCT
AGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGAT
ATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAA
CACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGA
TACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAG
GTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCT
GTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCC
TCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACA
GGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAA
GAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGA
CTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCG
TGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCA
GGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACG
GAATGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTG
TATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGT
TGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTC
CGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAG
AAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGC
AGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCT
TACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGCAAA
CAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCT
TTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTG
TACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCA
CCATAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCT
GTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACT
GAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAAT
TAATTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCAT
CTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGT
TAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTCTCCCACTTCAATT

>69005_69005_2_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000324631_length(amino acids)=741AA_BP=121
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRE
RGEPIRLFGETDYDAFQRLRKIEILTPEVNKSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREA
ERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQR
AKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVP
SMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQ
LVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEA
YWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGL
SRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDG

--------------------------------------------------------------
>69005_69005_3_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000352115_length(transcript)=2314nt_BP=523nt
CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG
GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA
GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGGAAAATAAAAAATATTTCAAGCGTAGTGAGCTCGCCAAAAAAGA
AGAGGAAGCATATTTTGAAAGATGTGGCTACAAGATACAGCCAAAAGAGGAGGACCAGAAACCATTAACTTCATCGAATCCAGTGTTAGA
ACTTGAACTGGCAGAGGAAAAATTACCTATGACGCTTTCTAGGCAAGAGGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAATCAGACT
ATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGTCATATGGAAAAGGAGC
CAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTC
CTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACA
GTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCC
TGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGA
AGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTA
CTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGGTGCAAA
ATCTGCAGATGAACAAGACCAGTGGAAAACTGCAGGCTTGTTTTGGCGGTTTACTACAGAGCACACTCCTCCGTATGATGTGGTACCTTC
CATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACA
CAGATTTGAAGGGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGC
AATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTT
GGTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTC
TCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGC
TCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTA
CTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCAC
CCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACC
TAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTC
CAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGA
CCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCG
GGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGA

>69005_69005_3_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000352115_length(amino acids)=718AA_BP=121
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRE
RGEPIRLFGETDYDAFQRLRKIEILTPEVNKSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREA
ERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQR
AKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSGAKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA
LFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPII
VYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATS
SLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKED

--------------------------------------------------------------
>69005_69005_4_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000377328_length(transcript)=1636nt_BP=523nt
CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG
GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA
GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGGAAAATAAAAAATATTTCAAGCGTAGTGAGCTCGCCAAAAAAGA
AGAGGAAGCATATTTTGAAAGATGTGGCTACAAGATACAGCCAAAAGAGGAGGACCAGAAACCATTAACTTCATCGAATCCAGTGTTAGA
ACTTGAACTGGCAGAGGAAAAATTACCTATGACGCTTTCTAGGCAAGAGGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAATCAGACT
ATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGTCATATGGAAAAGGAGC
CAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTC
CTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACA
GTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCC
TGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGC
TAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCT
TGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCT
TAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCG
CTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGC
CCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGC
CTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGG
GAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAG
CCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGATGT

>69005_69005_4_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000377328_length(amino acids)=492AA_BP=121
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRE
RGEPIRLFGETDYDAFQRLRKIEILTPEVNKSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREA
ERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDV
ILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQ
HRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHN

--------------------------------------------------------------
>69005_69005_5_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000377331_length(transcript)=2314nt_BP=523nt
CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG
GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA
GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGGAAAATAAAAAATATTTCAAGCGTAGTGAGCTCGCCAAAAAAGA
AGAGGAAGCATATTTTGAAAGATGTGGCTACAAGATACAGCCAAAAGAGGAGGACCAGAAACCATTAACTTCATCGAATCCAGTGTTAGA
ACTTGAACTGGCAGAGGAAAAATTACCTATGACGCTTTCTAGGCAAGAGGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAATCAGACT
ATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGTCATATGGAAAAGGAGC
CAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTC
CTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACA
GTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCC
TGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGA
AGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTA
CTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGGTGCAAA
ATCTGCAGATGAACAAGACCAGTGGAAAACTGCAGGCTTGTTTTGGCGGTTTACTACAGAGCACACTCCTCCGTATGATGTGGTACCTTC
CATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACA
CAGATTTGAAGGGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGC
AATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTT
GGTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTC
TCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGC
TCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTA
CTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCAC
CCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACC
TAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTC
CAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGA
CCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCG
GGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGA

>69005_69005_5_PRPF18-CACNB2_PRPF18_chr10_13647744_ENST00000378572_CACNB2_chr10_18439812_ENST00000377331_length(amino acids)=718AA_BP=121
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRE
RGEPIRLFGETDYDAFQRLRKIEILTPEVNKSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREA
ERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQR
AKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSGAKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA
LFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPII
VYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATS
SLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRPF18-CACNB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRPF18-CACNB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRPF18-CACNB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource