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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRR16-SCAMP1 (FusionGDB2 ID:69159)

Fusion Gene Summary for PRR16-SCAMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRR16-SCAMP1
Fusion gene ID: 69159
HgeneTgene
Gene symbol

PRR16

SCAMP1

Gene ID

51334

9522

Gene nameproline rich 16secretory carrier membrane protein 1
SynonymsDSC54|LARGENSCAMP|SCAMP37
Cytomap

5q23.1

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionprotein Largenmesenchymal stem cell protein DSC54proline-rich protein 16secretory carrier-associated membrane protein 1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000407149, ENST00000379551, 
ENST00000446965, ENST00000505123, 
ENST00000339292, ENST00000538629, 
Fusion gene scores* DoF score6 X 5 X 4=1204 X 4 X 4=64
# samples 64
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRR16 [Title/Abstract] AND SCAMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRR16(119800340)-SCAMP1(77711344), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRR16

GO:0045727

positive regulation of translation

24656129

HgenePRR16

GO:0045793

positive regulation of cell size

24656129

TgeneSCAMP1

GO:0015031

protein transport

15840657


check buttonFusion gene breakpoints across PRR16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCAMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A614-01APRR16chr5

119800340

+SCAMP1chr5

77711344

+
ChimerDB4LGGTCGA-HT-A614PRR16chr5

119800340

+SCAMP1chr5

77711344

+


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Fusion Gene ORF analysis for PRR16-SCAMP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000407149ENST00000339292PRR16chr5

119800340

+SCAMP1chr5

77711344

+
5UTR-3CDSENST00000379551ENST00000538629PRR16chr5

119800340

+SCAMP1chr5

77711344

+
5UTR-3UTRENST00000379551ENST00000339292PRR16chr5

119800340

+SCAMP1chr5

77711344

+
In-frameENST00000407149ENST00000538629PRR16chr5

119800340

+SCAMP1chr5

77711344

+
intron-3CDSENST00000446965ENST00000538629PRR16chr5

119800340

+SCAMP1chr5

77711344

+
intron-3CDSENST00000505123ENST00000538629PRR16chr5

119800340

+SCAMP1chr5

77711344

+
intron-3UTRENST00000446965ENST00000339292PRR16chr5

119800340

+SCAMP1chr5

77711344

+
intron-3UTRENST00000505123ENST00000339292PRR16chr5

119800340

+SCAMP1chr5

77711344

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407149PRR16chr5119800340+ENST00000538629SCAMP1chr577711344+63213681821249355

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407149ENST00000538629PRR16chr5119800340+SCAMP1chr577711344+0.0001193190.9998807

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Fusion Genomic Features for PRR16-SCAMP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRR16chr5119800340+SCAMP1chr577711343+6.90E-070.9999993
PRR16chr5119800340+SCAMP1chr577711343+6.90E-070.9999993
PRR16chr5119800340+SCAMP1chr577711343+6.90E-070.9999993
PRR16chr5119800340+SCAMP1chr577711343+6.90E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRR16-SCAMP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:119800340/chr5:77711344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRR16chr5:119800340chr5:77711344ENST00000379551+1333_700282.0Coiled coilOntology_term=ECO:0000255
HgenePRR16chr5:119800340chr5:77711344ENST00000407149+1233_7053305.0Coiled coilOntology_term=ECO:0000255
HgenePRR16chr5:119800340chr5:77711344ENST00000446965+1333_700235.0Coiled coilOntology_term=ECO:0000255
HgenePRR16chr5:119800340chr5:77711344ENST00000505123+1433_700235.0Coiled coilOntology_term=ECO:0000255
HgenePRR16chr5:119800340chr5:77711344ENST00000379551+13102_2910282.0Compositional biasNote=Pro-rich
HgenePRR16chr5:119800340chr5:77711344ENST00000407149+12102_29153305.0Compositional biasNote=Pro-rich
HgenePRR16chr5:119800340chr5:77711344ENST00000446965+13102_2910235.0Compositional biasNote=Pro-rich
HgenePRR16chr5:119800340chr5:77711344ENST00000505123+14102_2910235.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for PRR16-SCAMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69159_69159_1_PRR16-SCAMP1_PRR16_chr5_119800340_ENST00000407149_SCAMP1_chr5_77711344_ENST00000538629_length(transcript)=6321nt_BP=368nt
GAGCCGAGCGCCGCGTCTCGGGAGTTGATGGCAGCACCACTGTGCGGCCGCCCGGCCGAGCGCGGAGCGCAGCCACTCGCCGCTGCCCAG
GGAGCGCCCAAGATGTGGGGGGACCGGGGCGGCAGCGGCCGTAGCAGCGCCAGGGACGGGGGCACGCAGCAGCCTCCGCTCGCCCGCCTG
TCCTGACCTGCCTCGCTTGCCCCCAAAGAATGTCAGCCAAGTCCAAGGGGAACCCCTCCTCGTCCTGTCCAGCCGAGGGACCGCCGGCAG
CCTCCAAAACCAAGGTGAAGGAACAGATCAAGATCATCGTGGAGGATTTGGAATTAGTCCTGGGCGACCTGAAGGACGTGGCCAAGGAAC
TTAAGGAGCCTCCACCAGGCGGTGTGAAGATGCCTAATGTACCCAATACACAACCAGCAATAATGAAACCAACAGAGGAACATCCAGCTT
ATACACAGATTGCAAAGGAACATGCATTGGCCCAAGCTGAACTTCTTAAGCGCCAGGAAGAACTAGAAAGAAAAGCCGCAGAATTAGATC
GTCGGGAACGAGAAATGCAAAACCTCAGTCAACATGGTAGAAAAAATAATTGGCCACCTCTTCCTAGCAATTTTCCTGTCGGACCTTGTT
TCTATCAGGATTTTTCTGTAGACATTCCTGTAGAATTCCAAAAGACAGTAAAGCTTATGTACTACTTGTGGATGTTCCATGCAGTAACAC
TGTTTCTAAATATCTTCGGATGCTTGGCTTGGTTTTGTGTTGATTCTGCAAGAGCGGTTGATTTTGGATTGAGTATCCTGTGGTTCTTGC
TTTTTACTCCTTGTTCATTTGTCTGTTGGTACAGACCACTTTATGGAGCTTTCAGGAGTGACAGTTCATTTAGATTCTTTGTATTCTTCT
TCGTCTATATTTGTCAGTTTGCTGTACATGTACTCCAAGCTGCAGGATTTCATAACTGGGGCATTGGTGGTTGGATTTCATCCCTTACTG
GTCTCAACCAAAATATTCCTGTTGGAATCATGATGATAATCATAGCAGCACTTTTCACAGCATCAGCAGTCATCTCACTAGTTATGTTCA
AAAAAGTACATGGACTATATCGCACAACAGGTGCTAGTTTTGAGAAGGCCCAACAGGAGTTTGCAACAGGTGTGATGTCCAACAAAACTG
TCCAGACCGCAGCTGCAAATGCAGCTTCAACTGCAGCATCTAGTGCAGCTCAGAATGCTTTCAAGGGTAACCAGATTTAAGAATCTTCAA
ACAATACACTGTTACCTTTTGACTGTACCTTTTTCTCCAGTTACTGTATTCTACAAATATTTTTATGTTCAAAACACACAGTACAGACAG
CATGGATATTTCCTGTTCACTTGTGCATGGGCTAAAACCAGGAAAACTTCCTTGTCTTATTACTTTACCTAATAGTTTCTTAATATTTCA
GTGCCCCTTGCAGAAAAAATATTACATGCTAAATAAATATTCTCCATATTTTTGGGGGATGACATTCAGTGAATTATTTCAGTGGTGACC
CACTGAAAATTAATAATGGTACTTATGATTAAAAACGCATTTAATACTAACTGCAGTAGTTCTTTCAAGAATCTTTAGAGATAAGGATTG
CACATTGGAAAAGTAAACCATGTTTCATTCCTTTTTCCCTATTTATATTGAAAGAAATAGGCCAGCAGAGACTTAGGGATTTTAAATTGG
CTTGCTTTTTAGCTGTTTCAGTCACCAGTGAAGAGCCTATGTGCATTTTGTAGTAGATAATGTAAAATTTGTCATCTTTTTCTTTTCTTT
TTTTTAGAATAGCTGATATTTTGATAACAATCTCTAATTTGCATGGGCACCACATTTCTTATATTAAAAGAATTAGTGTTTTGGCTTCTG
TACTGCTTATGGTTGTAGGATTCAGGGGTTAATGGAATCACAGAAATGATATTCTGCAAGAATTTCTTTTAAATAAAAAGTTTGGGGGTG
CAATATAAGAAGTTTATATAATATGCAGTACATTATCCAAAAGAGAAGGTAGTTAATGCAGTAGAAAGTAGTGGTAATAATTCCTTTTTA
AAAAAATTTCGGTAGTCATATAGTAACATTTTGCTATATGAAAACTTTGGTATATTCTGTGGTTACAACTAAGATTGTGTCTGGCAGCTC
TTTTTTGGGGATGTGTGTGTGTGATTTTTAACAGAGGTATTAAAGGCTAGCCTAACTGTTGTCTAAAAAGATTGTACAGTATTTAAGGGA
TTTTCCTTTTAGCTTTTCATCTCCAGTGGCATTAAACATAAAAAGACCCTGGCATTTTTTCACATACTTGAATCCCTAAATGCACCTGTC
TTTCACTTTTTGAGACAGACTGAATATATCTAAAATTTCCAGCAATAAAAAAAAAAGCATTTAACTTGCACCAAGCAAGAAAATATAAAT
ACAGTTAACTGCATTAAGATAATCACGTTAAAATTGTTACTATGCAGCACAGAACTTCATTCTTATAGTATTCTTGGGTTCAACCTTTGA
ATCAATTTTACCACTGATTAAATAAATGACTCAAAGACATCTGTAAGTCATGCTGCTGTGTTTTGAAAGTCTTTAACTAAATTAAGATTG
CAGAATGATAGTGATTATTCAATTAGATTTTAAGTAAGGATTGTGATATTAGAGGCTGGAAATCCTTATTTTTTAAAAAATCAGATAGGC
ATAAATAGTTAAATCACTTTCATTCTCCCCAAACCTGTAGTTACAGAAAAAGTTTTATGCTAGAGGTGGGATGCCAAGTTTTCACTATCC
ATGAAGCAGCGCTGCATGTCACTAGGTAACACAGATCCATCCAGATGGTGTTTACATTTGATTTATTTGGGATCTTATTGACATCAGGTA
TACTTGGAAGACATTTCTTTTATTCTTCAGCGTATGAATTTAAAGCTATTTTTTGTAAATATTTCTAATCAGCGATAATTTCTACCTATG
TTCTCAACCAACTTAGCCAGTTTGTTTTTCAGAGCCTGTAGTCTTATTGGAAATCTATTTTATCAGTGTGCTTTATTGAGTGTGGATTTT
GCATACATTCAAAACATTAACCACAAAATACAGCAAGTGCACCTATATTCACCATTAACTTATATCCCAAGTCCATTTTTTCCTGTACAC
TACAAACAAAAGATATATTAGAGACTTTTGAAAAATGCTGAAATACTTTGCTTCAGAATTGGAATGTTTATATTATGTAGAAATCTTCAA
AGGTAGCATTATTAAATAGCAAAGAATAATTAGAACCCACATATCTTTTTTTGTGTGGATGGGGAAAATGTTTTAAAATCCAGTTATTTA
ATATGAGTTTGAGAGAGAAAATTGTTTTTTAAAAATATATGTGCATTGAAATGATGGCAATGCTTATAGTATGATCAAGTATGAAAGGAA
CTTTAAATTCTTATATTTACTTTTCTCTCAGTAAATTGTTAAATTTTCACTCAGCAAAAGATTGGCATTTGTTAAGTGTTCTATATTTAG
TACTAAAATCACAGTCATGAAATCATAGTCATAAAATGGTCTTCACACAGCAGTCATCCGTGTCATTTATCATTTTGTAATATTAAATTA
TGGCAATTTTATTTCAAACTAAAGTTTGAACACCGGAAAGTCATTACTCAGTGATTTGTAATTTGGGACTTGGATTATTTATCTAGAGAT
GTTTGTATATTTTGTCAGTAACTAATACTGCGCTGCCATCATGGTGACTGTCATGGTTCTACAGAAATGCCCTCCATGTGTCCCTCTAAT
GTTGCATGTTTCAGTGGGTTGGAAGTTTTGTATATTTATTGTATTAACACAGAGTGTCATAAAATAAAATGCTGTTTACTGGATGTTTGT
TTGTATAATTTTGAACACTATAATAGCAATTCAGAGACAGACATTGTTAAAGGTTTGATGTATATAGAAATTCCATGTTTGATTTTTTAA
AATATGTGTATAAGTCTGTCATGTGCTAAACAAAATAATATGAAAGACCTAGTTAAAAATTCTAACCAATGTAAAATGACCATTTTTCTG
TTGCATTAGACCTTTACAGGTAATGGAACATGAGCTTCACCCATATTAAATATTTTGGCCCCTTTAAGGTCAAAATACAGATCATCTAGA
AGTTAGATTCAAAATGGAAAACCTATTCATGGCTCAGATTTTTCATTGTGGGTTAAAAATGGGTGTCTCTGTACTAGTATTGTATTTATT
CAATTGAACTTGTATTCTGATTTCTATCCTTGCTACCTATTGCTGTTTTATGTACTGATGAAAGTACCTATTTGTGTATATTGGATTTTT
CACTTGGTTAGCTAAAGAAGATGTAAAAATATCTAAAATAATGTTCATGGTGAATCTTATTTTGAGAAATACATGTTAAAAAAGGAACAG
TATTCTTTATTTTCTGGGTGTTATATTTAAAAAAGCAAGTTTGGATTTTTACACCTAATTTACTAGGAAAATATTTTATTCTGTAATTCA
TGTTAAGATTATGTATGGTTTGCATTTTAAGGGGATTTATGTTAGGTTAATTAGTTGTTTCTGTAAATCATTTGTAATAGCATAGTGCTT
TTTACTCATTGCTGTATCTTTTTCTGAAAACACTGTTGTTAACATCTAATTCAGTATCCTTATTGGTACAAATCTGTGTTTGGCATGACT
GTTTATATACAGAATTTGTTACATTTTGAGCATTTTTTCCCCTGCTTATGTATACCTTAGAGTTACCATGGCTGTCATATACCATTTCAC
TATATCTCCTTTCAGTTTTTCCTTAAGGAAAATGTTTAGAGGAATTTGTTCATTTCATGTGATTAAGCCCTTTAGAGATGAAATAAGATT
GGTTAATTTTAAAAAAATTGAGGATGGTTAAAAAATAGAAAACACCTTACTTTGATACATTTTAAAGTACAATAGTATACATTTATTTAG
AGTAGACTAATGTGTTTAAAACATGAGTTGTTTTAAATACTTTTTTATTGAGCTAAAAAGTTTTATCTCACATATTAAGTATTACAGAAA
GTGAAGTATTTTGGCTAGAATTTTAGGGCATATTTTATAAAGCAGCATGCCTGTAATATTGGTGGGTATTTTTAAACTTTAGGACTTTAT
CACAGTATGTAGAGAGCTAGAAATAAATCTAGAAACTTTCTAAGCCAGGTATTGCCACTAACCTGTCTTATATAAGCAGATACCTCTTAT
TTGAAGATTGTAGGAAAATAGAGAAAGACTGTTCTCCAGTTTTCTCACCCCCGCTGTGGGTTTTATATTTACAATTTAACTTTGGGGTTT
GGGTAAGACAAACATTTAATGTATAGGATTTTGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCG
GATCACGAGGTCAGGAGATCGAAACCATCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAAAAATTAGCTGAGCAT
GGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGACGTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGA
TCTCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCTCAAGAAAAAAAAAAAAGAATTTTCATTAGTGCTGGCCGTGTTTC
AAATGGCAAGGGAACATGGGAACTATCATGTGGCAATGTAGTGAGTGTTAAACTTTGTGTTTGTCCAAATCCTGATTTATTTTTCAGTTC
ATATCTTTCTGGGCTTGACATGGCTGATGGTGTAGCTGAAACCCTCCTAACACTAAAAGCCATTTAATCTTTTCTGTAATAGGAGCAGAA
AATAGTTAATCATCCACCTAGTAATATAAGATTACTGTGAATATTATCTTCTATACATTAAAACAGTTCTAGTTTGTAGAATAATACCAT
ACAAGTTTTATTTTTAAATTCTAGTTATTTTCAGTGCTTACTTAAATGTAATTCTAGAATTCCTCCACAACTTTTAATATTTTGTATGCC
AGTGATTCTCAAGATAAATCATGATTGTAGTAGTTGTTACTGTTGGCAGTTTGTAGTAGTATTCAGGTATTTTGGGGATGGGGGAAAACA
CCAAAAATCAGTGTCTTTTATCTGGTGATCACTGTGGTATCTACAGTATTCTAGTCTCCTGCACAAAAACTGAACCCACTGGGCCTATGC
ATCCCTCACACTTTTTTTCTAGTATAAAAGCAATACATAATGTGTTGTAGAACAATTAAAAATTCAGAAAGTGATACATGAGAAAATAAA

>69159_69159_1_PRR16-SCAMP1_PRR16_chr5_119800340_ENST00000407149_SCAMP1_chr5_77711344_ENST00000538629_length(amino acids)=355AA_BP=62
MTCLACPQRMSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEPPPGGVKMPNVPNTQPAIMKPTEEHPAY
TQIAKEHALAQAELLKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTL
FLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGIGGWISSLTG

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Fusion Gene PPI Analysis for PRR16-SCAMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRR16-SCAMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRR16-SCAMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource