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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRRC2B-PPAPDC3 (FusionGDB2 ID:69228)

Fusion Gene Summary for PRRC2B-PPAPDC3

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRC2B-PPAPDC3
Fusion gene ID: 69228
HgeneTgene
Gene symbol

PRRC2B

PPAPDC3

Gene ID

84726

84814

Gene nameproline rich coiled-coil 2Bphospholipid phosphatase 7 (inactive)
SynonymsBAT2L|BAT2L1|KIAA0515|LQFBS-1C9orf67|NET39|PPAPDC3
Cytomap

9q34.13

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionprotein PRRC2BHLA-B associated transcript 2-likeHLA-B-associated transcript 2-like 1proline-rich coiled-coil protein 2Bprotein BAT2-like 1inactive phospholipid phosphatase 7epididymis secretory sperm binding proteinnuclear envelope transmembrane protein NET39phosphatidic acid phosphatase type 2 domain containing 3phosphatidic acid phosphatase type 2 domain-containing protein 3probable
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357304, ENST00000405995, 
ENST00000458550, ENST00000372249, 
ENST00000465931, 		ENST00000372261, 
ENST00000372264, 
Fusion gene scores* DoF score25 X 25 X 14=87502 X 1 X 2=4
# samples 363
** MAII scorelog2(36/8750*10)=-4.60321420527738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context

PubMed: PRRC2B [Title/Abstract] AND PPAPDC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRRC2B(134358832)-PPAPDC3(134183310), # samples:1
PRRC2B(134269650)-PPAPDC3(134183310), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PRRC2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPAPDC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1707-02APRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
ChimerDB4OVTCGA-30-1892-01APRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+


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Fusion Gene ORF analysis for PRRC2B-PPAPDC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357304ENST00000372261PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
5CDS-intronENST00000405995ENST00000372261PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
5CDS-intronENST00000458550ENST00000372261PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
5UTR-3CDSENST00000372249ENST00000372264PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
5UTR-3CDSENST00000405995ENST00000372264PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
5UTR-intronENST00000372249ENST00000372261PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
5UTR-intronENST00000405995ENST00000372261PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
In-frameENST00000357304ENST00000372264PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
In-frameENST00000405995ENST00000372264PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
In-frameENST00000458550ENST00000372264PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
intron-3CDSENST00000357304ENST00000372264PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-3CDSENST00000372249ENST00000372264PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-3CDSENST00000458550ENST00000372264PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-3CDSENST00000465931ENST00000372264PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-3CDSENST00000465931ENST00000372264PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+
intron-intronENST00000357304ENST00000372261PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-intronENST00000372249ENST00000372261PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-intronENST00000458550ENST00000372261PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-intronENST00000465931ENST00000372261PRRC2Bchr9

134269650

+PPAPDC3chr9

134183310

+
intron-intronENST00000465931ENST00000372261PRRC2Bchr9

134358832

+PPAPDC3chr9

134183310

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405995PRRC2Bchr9134358832+ENST00000372264PPAPDC3chr9134183310+4944360422636241132
ENST00000357304PRRC2Bchr9134358832+ENST00000372264PPAPDC3chr9134183310+685555155555351826
ENST00000458550PRRC2Bchr9134358832+ENST00000372264PPAPDC3chr9134183310+47183378033981132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405995ENST00000372264PRRC2Bchr9134358832+PPAPDC3chr9134183310+0.0046434680.9953565
ENST00000357304ENST00000372264PRRC2Bchr9134358832+PPAPDC3chr9134183310+0.0028535370.9971464
ENST00000458550ENST00000372264PRRC2Bchr9134358832+PPAPDC3chr9134183310+0.0033588890.99664116

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Fusion Genomic Features for PRRC2B-PPAPDC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRRC2Bchr9134358832+PPAPDC3chr9134183309+4.37E-091
PRRC2Bchr9134269650+PPAPDC3chr9134183309+3.15E-161
PRRC2Bchr9134358832+PPAPDC3chr9134183309+4.37E-091
PRRC2Bchr9134269650+PPAPDC3chr9134183309+3.15E-161

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRRC2B-PPAPDC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:134358832/chr9:134183310)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000357304+22311563_158718202230.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000357304+2231495_55318202230.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000405995+2231495_55311261536.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000458550+2130495_55311261536.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000357304+2231391_39518202230.0Compositional biasNote=Poly-Glu
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000357304+2231616_64718202230.0Compositional biasNote=Gln-rich
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000405995+2231391_39511261536.0Compositional biasNote=Poly-Glu
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000405995+2231616_64711261536.0Compositional biasNote=Gln-rich
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000458550+2130391_39511261536.0Compositional biasNote=Poly-Glu
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000458550+2130616_64711261536.0Compositional biasNote=Gln-rich
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402163_202150272.0Topological domainCytoplasmic
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402224_239150272.0Topological domainExtracellular
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402261_271150272.0Topological domainCytoplasmic
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402203_223150272.0TransmembraneHelical
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402240_260150272.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000372249+16241563_15870269.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000372249+1624495_5530269.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000405995+22311563_158711261536.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000458550+21301563_158711261536.0Coiled coilOntology_term=ECO:0000255
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000357304+22311953_195618202230.0Compositional biasNote=Poly-Ala
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000372249+16241953_19560269.0Compositional biasNote=Poly-Ala
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000372249+1624391_3950269.0Compositional biasNote=Poly-Glu
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000372249+1624616_6470269.0Compositional biasNote=Gln-rich
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000405995+22311953_195611261536.0Compositional biasNote=Poly-Ala
HgenePRRC2Bchr9:134358832chr9:134183310ENST00000458550+21301953_195611261536.0Compositional biasNote=Poly-Ala
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402134_141150272.0Topological domainExtracellular
TgenePPAPDC3chr9:134358832chr9:134183310ENST00000372264021_112150272.0Topological domainCytoplasmic
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402113_133150272.0TransmembraneHelical
TgenePPAPDC3chr9:134358832chr9:134183310ENST0000037226402142_162150272.0TransmembraneHelical


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Fusion Gene Sequence for PRRC2B-PPAPDC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69228_69228_1_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000357304_PPAPDC3_chr9_134183310_ENST00000372264_length(transcript)=6855nt_BP=5515nt
GCAGATCGGGAGCGGTGCCGAGAAAAATTTCCTTACTAGATGACATTTCATCGCAATGTCCGATCGTTTGGGGCAAATTACCAAGGGCAA
GGATGGGAAAAGCAAGTACTCGACTCTCAGCCTGTTTGATAAGTATAAAGGAAAATCAGTAGACGCGATTAGATCCTCAGTTATTCCTAG
ACATGGCTTACAGAGTCTTGGGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCTGCAAACCTGCCAAGCTTGAAGTCTGAAAACAAAGG
AAACGACCCCAACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAAACAAGCAGGATCAGCAAGACCCAAAGAGTTCCAGTGCGAC
GGCCTCTCAGCCGCCGGAGTCGCTGCCGCAGCCGGGTTTGCAGAAATCTGTCTCCAATTTGCAGAAACCGACACAGTCAATCAGTCAGGA
GAATACAAATTCAGTGCCAGGTGGACCAAAGTCATGGGCACAGCTGAATGGAAAGCCAGTAGGACACGAAGGTGGTTTAAGGGGCTCAAG
CCGACTGTTATCCTTCTCTCCCGAGGAATTTCCGACGCTGAAAGCAGCTGGAGGGCAGGACAAGGCTGGCAAAGAAAAGGGCGTCTTAGA
TCTGTCGTATGGGCCAGGACCAAGCCTCCGCCCTCAGAATGTGACAAGCTGGAGGGAGGGCGGTGGGCGACACATAATTTCTGCCACGTC
TCTGAGCACCTCCCCAACTGAGCTGGGCAGCAGGAACTCGAGTACGGGAGATGGAGCCCCCTCCTCGGCATGTACCAGCGATTCTAAGGA
CCCCTCTCTCCGCCCGGCTCAGCCTGTCCGAAAAGGGGCTTCACAGTTCATGGGAAATGTATACCACCCACCTACATACCATGACATGCT
TCCTGCTTTTATGTGTTCGCCGAAGTCATCAGAAAACCAGGGTACAGTGGAACGAGGCTCTTTTCCCCTTCCTCAGCTCCGCCTTGAACC
TCGAGTTCCTTTTAGACAGTTCCAGATGAATGACCAAGACGGAAAAGAAAACAGGCTGGGATTGTCTCGCCCACTCCGCCCACTAAGGCA
GCTGGTGGAGCGGGCACCACGGCCCACCATTATCAATGCGGAAAACCTGAAGGGCCTTGACGATCTGGACGCCGATGCCGATGATGGCTG
GGCAGGCCTCCATGAAGAAGTGGACTATTCTGAGAAACTGAAGTTCAGTGATGATGAAGAGGAGGAAGAAGTTGTGAAGGACGGCAGGCC
AAAGTGGAACAGTTGGGACCCTAGGAGGCAGCGGCAGTTGTCAATGAGCTCTGCAGACAGTGCGGACGCTAAGCGGACTCGAGAGGAAGG
GAAGGACTGGGCTGAAGCAGTGGGTGCGTCCCGTGTGGTCCGAAAGGCGCCAGACCCTCAGCCACCGCCCAGGAAGCTTCATGGCTGGGC
ACCAGGCCCTGACTACCAGAAGTCATCAATGGGCAGCATGTTCCGGCAACAGTCCATCGAGGACAAGGAGGACAAGCCCCCACCAAGGCA
GAAGTTCATTCAGTCAGAGATGTCCGAGGCGGTGGAGCGAGCCCGAAAGCGCCGGGAAGAAGAGGAGCGCCGAGCCCGGGAGGAGAGGCT
GGCCGCCTGTGCTGCCAAACTCAAGCAGCTGGACCAGAAGTGTAAGCAGGCACGAAAGGCAGGTGAGGCCCGGAAGCAGGCAGAGAAGGA
AGTGCCCTGGTCTCCAAGTGCTGAGAAGGCATCTCCCCAGGAAAACGGCCCTGCTGTCCACAAAGGCTCCCCAGAATTCCCTGCCCAAGA
GACCCCCACCACATTCCCAGAAGAGGCACCCACAGTGTCCCCAGCAGTGGCACAGAGCAACAGCAGTGAGGAAGAGGCCAGAGAGGCTGG
GTCCCCTGCACAGGAGTTCAAGTATCAGAAGTCCCTTCCTCCCCGATTCCAGCGCCAGCAGCAGCAACAACAGCAGGAGCAGCTGTACAA
GATGCAGCACTGGCAGCCGGTGTACCCCCCGCCGTCCCACCCCCAGCGCACCTTTTACCCACACCACCCCCAGATGTTGGGCTTCGATCC
CAGGTGGATGATGATGCCTTCCTACATGGACCCACGTATCACGCCCACTCGGACCCCGGTGGACTTCTACCCCTCCGCCCTGCATCCCTC
AGGACTGATGAAGCCCATGATGCCCCAGGAGTCCCTCAATGGGACAGGCTGTCGCTCTGAGGATCAGAACTGTGTGCCCCCACTCCAAGA
AAGAAAAGTGACCCCCATCGACTCACCCCCTGTGTGGAGCCCAGAGGGCTACATGGCACTGCAGAGCAAGGGCTACCCGCTCCCGCACCC
GAAGTCGAGTGACACCTTGGCTATGGACATGCGTGTCAGGAATGAAAGCTCTTTCTCTGCCTCACTCGGAAGGGCAGGGGGCGTAAGTGC
TCAGCGCGATCTCTTTGAGGAGAGAGGGGAGGAGTACTTGAGTGCTTTTGACAAGAAGGCCCAAGCAGACTTTGACAGCTGTATCTCTTC
TCAAAGAATAGGCCAGGAGCTTTTGTTTCCACCCCAAGAAAATGTTCAGGATGCAGGTGCTCCTGGGGGTCACACCCAAAACCTCAGGTG
TTCCCCATTGGAGCCTGACTTTGTCCCAGATGAGAAAAAGCCAGAGTGTGGCAGTTGGGATGTTAGCCACCAGCCAGAGACCGCTGACAC
AGCCCATGGTGTTGAGCGGGAGACACCCCGGGAGGGGACGGCCTTTAACATCTCCTCCTGGGACAAGAACGGGAGCCCCAACAAACAGCC
ATCCTCGGAGCCTGAATGGACTCCCGAGCCCCGGAGCTCCAGCAGCCAGCACCCGGAGCAGACGGGCAGGACCCGGAGGTCGGGACCCAT
CAAGAAACCAGTCCTGAAAGCCCTCAAGGTGGAAGACAAGGAGAAGGAGCTTGAGAAGATTAAGCAGGAGCTAGGGGAGGAGAGTACCCG
GCTGGCCAAGGAGAAGGAGCAGAGCCCCACGGCAGAAAAGGATGAGGACGAAGAGAACGATGCCTCTCTGGCCAACTCCTCCACCACCAC
TTTGGAGGACAAAGGCCCTGGCCATGCCACTTTTGGCCGCGAGGCCACCAAATTTGAAGAGGAGGAGAAACCTGACAAGGCCTGGGAAGC
CAGACCCCCACGAGAGTCCAGCGATGTTCCCCCCATGAAGAGAAATAACTGGATCTTTATTGATGAGGAGCAAGCCTTTGGGGTCAGAGG
ACAGGCCCGGGGCCGGGGCCGTGGTTTCAGAGAGTTCACTTTTCGTGGTCGGCCTGCTGGCGGAAATGGGAGCGGCCTCTGTGGTGGGGG
GGTCCTGGGGGCCCGCAGCATCTACTGCAGCAGTCAGCGCAGCGGCCGTGGCCGGGGCCTGCGAGAGTTTGCGCGGCCAGAGGACTGCCC
CAGAGCCAAGCCCCGACGGAGAGTTGCCAGTGAGACCCATAGCGAGGGCTCAGAGTATGAAGAACTTCCCAAGCGCCGCCGGCAGAGGGG
CTCCGAGAACGGGAATGAAGGCTCGCTCCTGGAGAGGGAGGAGAGCACCTTGAAGAAGGGCGACTGCAGAGATTCTTGGCGGTCCAACAA
GGGGTGCTCTGAGGACCACAGCGGTCTAGATGCCAAGAGCCGAGGCCCTCGGGCCTTTGGGCGAGCCCTCCCTCCCCGGCTGAGCAATTG
CGGGTATGGACGGAGAACCTTCGTCTCCAAAGAGTCACCCCACTGGCAGAGCAAAAGTCCAGGCAGCTCTTGGCAGGAATATGGCCCTTC
CGACACATGCGGATCCCGGCGACCTACAGACAGAGACTATGTCCCAGATTCCTACAGACACCCTGACGCATTTGGTGGCCGGGGCTTTGA
GGACAGCCGCGCGGAGGACAAGAGATCCTTCTTCCAAGATGAACACGTGGCAGATTCTGAAAATGCAGAGAACCGGCCCTTCAGGAGAAG
GCGCCCCCCACGCCAAGATAAGCCCCCTCGATTCCGGCGCCTCCGGCAAGAGCGGGAGTCCCTGGGCCTGTGGGGACCCGAGGAGGAGCC
CCACCTGCTGGCAGGTCAGTGGCCAGGCAGGCCCAAACTGTGTTCTGGGGACAAGAGTGGCACTGTGGGCCGCAGGTCCCCTGAGCTCTC
CTACCAGAACTCCTCCGATCACGCCAATGAGGAGTGGGAGACGGCCTCCGAAAGCAGCGACTTCAGCGAGCGGCGGGAGCGGCGGGAAGG
CCCTGGGTCCGAGCCCGACTCCCAGGTGGATGGTGGCCTGTCGGGGGCTAGTTTGGGTGAGAAGAAGGAGCTGGCCAAGAGGAGCTTCTC
CAGTCAGAGACCCGTGGTTGACAGACAGAGCCGAAAGCTGGAGCCGGGAGGGTTTGGGGAGAAGCCCGTTAGGCCAGGTGGTGGTGACAC
CTCCCCTCGCTATGAGAGCCAACAGAATGGGACGCCTTTGAAAGTGAAAAGATCCCCAGACGAGGCCTTGCCTGGAGGTCTTAGTGGCTG
CAGCAGTGGGAGTGGCCACTCCCCCTATGCCCTGGAGCGGGCAGCCCATGCCAGTGCTGACCTTCCCGAAGCCTCCAGTAAAAAGGCAGA
GAAGGAGGCCAAGTTGGCTGCTCCGAGGGCAGGTGAACAGGGAGAGGCCATGAAACAGTTTGACCTGAACTATGGAAGTGCCATCATTGA
AAATTGCGGGTCCAGCCCCGGGGAGGAGAGTGAGGTGGGTTCTATGGTGGGCGAAGGCTTCATCGAAGTCCTGACCAAGAAGCAGCGCCG
CCTGCTGGAGGAAGAGAGAAGAAAGAAGGAGCAGGCCGTGCAGGTGCCTGTCAAAGGTCGAGGCCTTTCCTCCCGTATTCCTCCTCGATT
TGCAAAAAAGCAGAACAACTTATGTCTGGAGCAAGGTGACGTGACCGTGCCTGGCAGCAGCCTGGGCACTGAGATCTGGGAGAGCAGCAG
CCAGGCTCTCCCTGTGCAGGCCCCAGCCAACGACTCCTGGAGGAAAGCTGTCACTGCCTTCAGCAGCACCGAGACTGGCTCTGCGGAGCA
GGGTTTTAAGAGCAGCCAGGGAGATAGTGGCGTTGACTTGAGTGCCGAGTCTCGGGAGTCGTCTGCGACCTCCTCGCAGCGCAGCTCCCC
ATATGGGACTCTGAAGCCAGAGGAGATGAGCGGGCCCGGCCTGGCGGAACCCAAGGCCGACAGCCACAAGGAGCAGGCTCCAAAGCCATC
TGAGCAGAAGGATTCAGAACAAGGCTCTGGACAGAGCAAGGAGCACAGACCAGGACCCATCGGCAACGAGCGTTCTCTGAAAAACAGAAA
GGGCTCGGAGGGGGCCGAGCGGCTGCAAGGGGCTGTCGTCCCGCCTGTTAACGGGGTGGAGATTCACGTGGACTCCGTGCTGCCTGTGCC
ACCCATTGAATTTGGAGTCAGTCCAAAAGACTCCGATTTCAGCTTGCCACCTGGTTCTGCCTCTGGTCCTACTGGGAGTCCAGTTGTTAA
ACTTCAGGATGCCTTGGCCAGTAATCCCTGCTCCTGGACATCATGACGGTGGCCGGCGTGCAGAAGCTCATCAAGCGGCGCGGCCCGTAC
GAGACGAGCCCCAGCCTCCTGGACTACCTCACCATGGACATCTACGCCTTCCCGGCCGGGCACGCCAGCCGCGCCGCCATGGTGTCCAAG
TTCTTCCTCAGCCACCTGGTGCTGGCGGTGCCCCTGCGTGTGCTGCTGGTGCTCTGGGCCCTCTGCGTGGGCCTGTCCCGCGTGATGATC
GGCCGCCACCACGTCACGGACGTCCTCTCCGGCTTTGTCATCGGCTACCTCCAGTTCCGTCTGGTGGAGCTGGTCTGGATGCCCTCCAGC
ACCTGCCAGATGCTCATCTCTGCCTGGTGAAGCGCCCGCCGGCCCACACAAGCCTCTGGGGGCAGGGCTGGCCCTAGAGAAGGGGCAGGG
GGTGGCGAGGTGGCGGGCGTGGGTGGAACAGAGCGGCCAGGAGTCAGAGCGGCCACCCCCACCTCATCTTCCCCTCCTGGCTGGAGGCTG
GCGAACCCAGGCCACCCCTCCCGGAGACAAGCGTGTTTGGCAGTGCCAGGCCTCTTGCCCCTTTGCTTGGACTCCAAGTCTCCTCTCTAG
GCAGCCAGGACCCACCCATGGGGACAGCCCTATTTAGCTTCTGCTCTGGGAACAGCAAAAATCAGGATGGTGGGAGGGGCCGAGTCTTGT
CTTGTCCTTTCATCATCATGACTGTTGAGTTCTTGGCTGTGCCCATCACGCCACAGCACGACGCCTGCCAAAATGCCCCCAACCTACTGC
CTGATGCAGGTGCCATTGCCATTAGCGGTCATCGACAGCTTAGGGCAGCACTTTCCAACGGGTGCCCATGGGACACCAGCCTGCGAGATG
CTTTTGGGGGAAAGGGGTTTTGTGGTTCAATAACTTTCGGAAGTGCTGCACACTCTGTCCCCAAGTTGGACATTCACAAAGGCCGTTATT
GCCGTAAAGGCTCTGACAAGCCCTATAGAAAAGCTTCTTGCTAAACCTTCTTTAACCCATGTTTTCTAAACTTATTTGACCACAGAACCC
TTTTCTTGGGGAACAGCTATTAACCCCCAAGGAATTATTGGTTCCTCAAGTGCGTTTTGGGAGCTGCTGCCAGAGAGCTAAAGGGCCTGG
GGTGTGAGCTGACTCTCCTCTGGGGAGGCCGGGTGCACACGCCACAGCCCGAGGAAAGTGCTGGCCACCGCCCGTGGGCATCGATGAGGC
TTTGGCCCCCAGGGGCCGGACTCCGTGTGACCTAATAGGTCGTTTCCAAGTCACCCGTTTTGGATGTGCATTTCATGTGACAATACAGAT

>69228_69228_1_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000357304_PPAPDC3_chr9_134183310_ENST00000372264_length(amino acids)=1826AA_BP=
MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANK
QDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG
QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMG
NVYHPPTYHDMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG
LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPD
PQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR
KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQR
QQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR
SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDK
KAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNIS
SWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSPTAEKDEDEE
NDASLANSSTTTLEDKGPGHATFGREATKFEEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRP
AGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLLEREESTLK
KGDCRDSWRSNKGCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSY
RHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQERESLGLWGPEEEPHLLAGQWPGRPKLCSGDK
SGTVGRRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGF
GEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMK
QFDLNYGSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG
SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPK
ADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG

--------------------------------------------------------------
>69228_69228_2_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000405995_PPAPDC3_chr9_134183310_ENST00000372264_length(transcript)=4944nt_BP=3604nt
GCGCCGAGGCTCCACCGCGCAGCGACGAGCGAGCCCGGGAGGAGGGAGGGAGCGAGCGAGCGAGCAGCCCGCGCCGCCGCCTCGCAATCC
GCCGCCATCCCGCCGCCCCCGTGCCCGACCGCCGCCCGACTGCCATCGCCCGGCCCGGCCGCGCCCGCGGAACCAGACCAGGCAGATCGG
GAGCGGTGCCGAGAAAAATTTCCTTACTAGATGACATTTCATCGCAATGTCCGATCGTTTGGGGCAAATTACCAAGGGCAAGGATGGGAA
AAGCAAGTACTCGACTCTCAGCCTGTTTGATAAGTATAAAGGAAAATCAGTAGACGCGATTAGATCCTCAGTTATTCCTAGACATGGCTT
ACAGAGTCTTGGGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCTGCAAACCTGCCAAGCTTGAAGTCTGAAAACAAAGGAAACGACCC
CAACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAAACAAGCAGGATCAGCAAGACCCAAAGAGTTCCAGTGCGACGGCCTCTCA
GCCGCCGGAGTCGCTGCCGCAGCCGGGTTTGCAGAAATCTGTCTCCAATTTGCAGAAACCGACACAGTCAATCAGTCAGGAGAATACAAA
TTCAGTGCCAGGTGGACCAAAGTCATGGGCACAGCTGAATGGAAAGCCAGTAGGACACGAAGGTGGTTTAAGGGGCTCAAGCCGACTGTT
ATCCTTCTCTCCCGAGGAATTTCCGACGCTGAAAGCAGCTGGAGGGCAGGACAAGGCTGGCAAAGAAAAGGGCGTCTTAGATCTGTCGTA
TGGGCCAGGACCAAGCCTCCGCCCTCAGAATGTGACAAGCTGGAGGGAGGGCGGTGGGCGACACATAATTTCTGCCACGTCTCTGAGCAC
CTCCCCAACTGAGCTGGGCAGCAGGAACTCGAGTACGGGAGATGGAGCCCCCTCCTCGGCATGTACCAGCGATTCTAAGGACCCCTCTCT
CCGCCCGGCTCAGCCTGTCCGAAAAGGGGCTTCACAGTTCATGGGAAATGTATACCACCCACCTACATACCATGACATGCTTCCTGCTTT
TATGTGTTCGCCGAAGTCATCAGAAAACCAGGGTACAGTGGAACGAGGCTCTTTTCCCCTTCCTCAGCTCCGCCTTGAACCTCGAGTTCC
TTTTAGACAGTTCCAGATGAATGACCAAGACGGAAAAGAAAACAGGCTGGGATTGTCTCGCCCACTCCGCCCACTAAGGCAGCTGGTGGA
GCGGGCACCACGGCCCACCATTATCAATGCGGAAAACCTGAAGGGCCTTGACGATCTGGACGCCGATGCCGATGATGGCTGGGCAGGCCT
CCATGAAGAAGTGGACTATTCTGAGAAACTGAAGTTCAGTGATGATGAAGAGGAGGAAGAAGTTGTGAAGGACGGCAGGCCAAAGTGGAA
CAGTTGGGACCCTAGGAGGCAGCGGCAGTTGTCAATGAGCTCTGCAGACAGTGCGGACGCTAAGCGGACTCGAGAGGAAGGGAAGGACTG
GGCTGAAGCAGTGGGTGCGTCCCGTGTGGTCCGAAAGGCGCCAGACCCTCAGCCACCGCCCAGGAAGCTTCATGGCTGGGCACCAGGCCC
TGACTACCAGAAGTCATCAATGGGCAGCATGTTCCGGCAACAGTCCATCGAGGACAAGGAGGACAAGCCCCCACCAAGGCAGAAGTTCAT
TCAGTCAGAGATGTCCGAGGCGGTGGAGCGAGCCCGAAAGCGCCGGGAAGAAGAGGAGCGCCGAGCCCGGGAGGAGAGGCTGGCCGCCTG
TGCTGCCAAACTCAAGCAGCTGGACCAGAAGTGTAAGCAGGCACGAAAGGCAGGTGAGGCCCGGAAGCAGGCAGAGAAGGAAGTGCCCTG
GTCTCCAAGTGCTGAGAAGGCATCTCCCCAGGAAAACGGCCCTGCTGTCCACAAAGGCTCCCCAGAATTCCCTGCCCAAGAGACCCCCAC
CACATTCCCAGAAGAGGCACCCACAGTGTCCCCAGCAGTGGCACAGAGCAACAGCAGTGAGGAAGAGGCCAGAGAGGCTGGGTCCCCTGC
ACAGGAGTTCAAGTATCAGAAGTCCCTTCCTCCCCGATTCCAGCGCCAGCAGCAGCAACAACAGCAGGAGCAGCTGTACAAGATGCAGCA
CTGGCAGCCGGTGTACCCCCCGCCGTCCCACCCCCAGCGCACCTTTTACCCACACCACCCCCAGATGTTGGGCTTCGATCCCAGGTGGAT
GATGATGCCTTCCTACATGGACCCACGTATCACGCCCACTCGGACCCCGGTGGACTTCTACCCCTCCGCCCTGCATCCCTCAGGACTGAT
GAAGCCCATGATGCCCCAGGAGTCCCTCAATGGGACAGGCTGTCGCTCTGAGGATCAGAACTGTGTGCCCCCACTCCAAGAAAGAAAAGT
GACCCCCATCGACTCACCCCCTGTGTGGAGCCCAGAGGGCTACATGGCACTGCAGAGCAAGGGCTACCCGCTCCCGCACCCGAAGTCGAG
TGACACCTTGGCTATGGACATGCGTGTCAGATCCCCAGACGAGGCCTTGCCTGGAGGTCTTAGTGGCTGCAGCAGTGGGAGTGGCCACTC
CCCCTATGCCCTGGAGCGGGCAGCCCATGCCAGTGCTGACCTTCCCGAAGCCTCCAGTAAAAAGGCAGAGAAGGAGGCCAAGTTGGCTGC
TCCGAGGGCAGGTGAACAGGGAGAGGCCATGAAACAGTTTGACCTGAACTATGGAAGTGCCATCATTGAAAATTGCGGGTCCAGCCCCGG
GGAGGAGAGTGAGGTGGGTTCTATGGTGGGCGAAGGCTTCATCGAAGTCCTGACCAAGAAGCAGCGCCGCCTGCTGGAGGAAGAGAGAAG
AAAGAAGGAGCAGGCCGTGCAGGTGCCTGTCAAAGGTCGAGGCCTTTCCTCCCGTATTCCTCCTCGATTTGCAAAAAAGCAGAACAACTT
ATGTCTGGAGCAAGGTGACGTGACCGTGCCTGGCAGCAGCCTGGGCACTGAGATCTGGGAGAGCAGCAGCCAGGCTCTCCCTGTGCAGGC
CCCAGCCAACGACTCCTGGAGGAAAGCTGTCACTGCCTTCAGCAGCACCGAGACTGGCTCTGCGGAGCAGGGTTTTAAGAGCAGCCAGGG
AGATAGTGGCGTTGACTTGAGTGCCGAGTCTCGGGAGTCGTCTGCGACCTCCTCGCAGCGCAGCTCCCCATATGGGACTCTGAAGCCAGA
GGAGATGAGCGGGCCCGGCCTGGCGGAACCCAAGGCCGACAGCCACAAGGAGCAGGCTCCAAAGCCATCTGAGCAGAAGGATTCAGAACA
AGGCTCTGGACAGAGCAAGGAGCACAGACCAGGACCCATCGGCAACGAGCGTTCTCTGAAAAACAGAAAGGGCTCGGAGGGGGCCGAGCG
GCTGCAAGGGGCTGTCGTCCCGCCTGTTAACGGGGTGGAGATTCACGTGGACTCCGTGCTGCCTGTGCCACCCATTGAATTTGGAGTCAG
TCCAAAAGACTCCGATTTCAGCTTGCCACCTGGTTCTGCCTCTGGTCCTACTGGGAGTCCAGTTGTTAAACTTCAGGATGCCTTGGCCAG
TAATCCCTGCTCCTGGACATCATGACGGTGGCCGGCGTGCAGAAGCTCATCAAGCGGCGCGGCCCGTACGAGACGAGCCCCAGCCTCCTG
GACTACCTCACCATGGACATCTACGCCTTCCCGGCCGGGCACGCCAGCCGCGCCGCCATGGTGTCCAAGTTCTTCCTCAGCCACCTGGTG
CTGGCGGTGCCCCTGCGTGTGCTGCTGGTGCTCTGGGCCCTCTGCGTGGGCCTGTCCCGCGTGATGATCGGCCGCCACCACGTCACGGAC
GTCCTCTCCGGCTTTGTCATCGGCTACCTCCAGTTCCGTCTGGTGGAGCTGGTCTGGATGCCCTCCAGCACCTGCCAGATGCTCATCTCT
GCCTGGTGAAGCGCCCGCCGGCCCACACAAGCCTCTGGGGGCAGGGCTGGCCCTAGAGAAGGGGCAGGGGGTGGCGAGGTGGCGGGCGTG
GGTGGAACAGAGCGGCCAGGAGTCAGAGCGGCCACCCCCACCTCATCTTCCCCTCCTGGCTGGAGGCTGGCGAACCCAGGCCACCCCTCC
CGGAGACAAGCGTGTTTGGCAGTGCCAGGCCTCTTGCCCCTTTGCTTGGACTCCAAGTCTCCTCTCTAGGCAGCCAGGACCCACCCATGG
GGACAGCCCTATTTAGCTTCTGCTCTGGGAACAGCAAAAATCAGGATGGTGGGAGGGGCCGAGTCTTGTCTTGTCCTTTCATCATCATGA
CTGTTGAGTTCTTGGCTGTGCCCATCACGCCACAGCACGACGCCTGCCAAAATGCCCCCAACCTACTGCCTGATGCAGGTGCCATTGCCA
TTAGCGGTCATCGACAGCTTAGGGCAGCACTTTCCAACGGGTGCCCATGGGACACCAGCCTGCGAGATGCTTTTGGGGGAAAGGGGTTTT
GTGGTTCAATAACTTTCGGAAGTGCTGCACACTCTGTCCCCAAGTTGGACATTCACAAAGGCCGTTATTGCCGTAAAGGCTCTGACAAGC
CCTATAGAAAAGCTTCTTGCTAAACCTTCTTTAACCCATGTTTTCTAAACTTATTTGACCACAGAACCCTTTTCTTGGGGAACAGCTATT
AACCCCCAAGGAATTATTGGTTCCTCAAGTGCGTTTTGGGAGCTGCTGCCAGAGAGCTAAAGGGCCTGGGGTGTGAGCTGACTCTCCTCT
GGGGAGGCCGGGTGCACACGCCACAGCCCGAGGAAAGTGCTGGCCACCGCCCGTGGGCATCGATGAGGCTTTGGCCCCCAGGGGCCGGAC

>69228_69228_2_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000405995_PPAPDC3_chr9_134183310_ENST00000372264_length(amino acids)=1132AA_BP=
MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANK
QDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG
QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMG
NVYHPPTYHDMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG
LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPD
PQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR
KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQR
QQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR
SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRSPDEALPGGLSGCSSGSGHSPYALERAAHASADLP
EASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGL
SSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSA
TSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIH

--------------------------------------------------------------
>69228_69228_3_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000458550_PPAPDC3_chr9_134183310_ENST00000372264_length(transcript)=4718nt_BP=3378nt
ATGTCCGATCGTTTGGGGCAAATTACCAAGGGCAAGGATGGGAAAAGCAAGTACTCGACTCTCAGCCTGTTTGATAAGTATAAAGGAAAA
TCAGTAGACGCGATTAGATCCTCAGTTATTCCTAGACATGGCTTACAGAGTCTTGGGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCT
GCAAACCTGCCAAGCTTGAAGTCTGAAAACAAAGGAAACGACCCCAACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAAACAAG
CAGGATCAGCAAGACCCAAAGAGTTCCAGTGCGACGGCCTCTCAGCCGCCGGAGTCGCTGCCGCAGCCGGGTTTGCAGAAATCTGTCTCC
AATTTGCAGAAACCGACACAGTCAATCAGTCAGGAGAATACAAATTCAGTGCCAGGTGGACCAAAGTCATGGGCACAGCTGAATGGAAAG
CCAGTAGGACACGAAGGTGGTTTAAGGGGCTCAAGCCGACTGTTATCCTTCTCTCCCGAGGAATTTCCGACGCTGAAAGCAGCTGGAGGG
CAGGACAAGGCTGGCAAAGAAAAGGGCGTCTTAGATCTGTCGTATGGGCCAGGACCAAGCCTCCGCCCTCAGAATGTGACAAGCTGGAGG
GAGGGCGGTGGGCGACACATAATTTCTGCCACGTCTCTGAGCACCTCCCCAACTGAGCTGGGCAGCAGGAACTCGAGTACGGGAGATGGA
GCCCCCTCCTCGGCATGTACCAGCGATTCTAAGGACCCCTCTCTCCGCCCGGCTCAGCCTGTCCGAAAAGGGGCTTCACAGTTCATGGGA
AATGTATACCACCCACCTACATACCATGACATGCTTCCTGCTTTTATGTGTTCGCCGAAGTCATCAGAAAACCAGGGTACAGTGGAACGA
GGCTCTTTTCCCCTTCCTCAGCTCCGCCTTGAACCTCGAGTTCCTTTTAGACAGTTCCAGATGAATGACCAAGACGGAAAAGAAAACAGG
CTGGGATTGTCTCGCCCACTCCGCCCACTAAGGCAGCTGGTGGAGCGGGCACCACGGCCCACCATTATCAATGCGGAAAACCTGAAGGGC
CTTGACGATCTGGACGCCGATGCCGATGATGGCTGGGCAGGCCTCCATGAAGAAGTGGACTATTCTGAGAAACTGAAGTTCAGTGATGAT
GAAGAGGAGGAAGAAGTTGTGAAGGACGGCAGGCCAAAGTGGAACAGTTGGGACCCTAGGAGGCAGCGGCAGTTGTCAATGAGCTCTGCA
GACAGTGCGGACGCTAAGCGGACTCGAGAGGAAGGGAAGGACTGGGCTGAAGCAGTGGGTGCGTCCCGTGTGGTCCGAAAGGCGCCAGAC
CCTCAGCCACCGCCCAGGAAGCTTCATGGCTGGGCACCAGGCCCTGACTACCAGAAGTCATCAATGGGCAGCATGTTCCGGCAACAGTCC
ATCGAGGACAAGGAGGACAAGCCCCCACCAAGGCAGAAGTTCATTCAGTCAGAGATGTCCGAGGCGGTGGAGCGAGCCCGAAAGCGCCGG
GAAGAAGAGGAGCGCCGAGCCCGGGAGGAGAGGCTGGCCGCCTGTGCTGCCAAACTCAAGCAGCTGGACCAGAAGTGTAAGCAGGCACGA
AAGGCAGGTGAGGCCCGGAAGCAGGCAGAGAAGGAAGTGCCCTGGTCTCCAAGTGCTGAGAAGGCATCTCCCCAGGAAAACGGCCCTGCT
GTCCACAAAGGCTCCCCAGAATTCCCTGCCCAAGAGACCCCCACCACATTCCCAGAAGAGGCACCCACAGTGTCCCCAGCAGTGGCACAG
AGCAACAGCAGTGAGGAAGAGGCCAGAGAGGCTGGGTCCCCTGCACAGGAGTTCAAGTATCAGAAGTCCCTTCCTCCCCGATTCCAGCGC
CAGCAGCAGCAACAACAGCAGGAGCAGCTGTACAAGATGCAGCACTGGCAGCCGGTGTACCCCCCGCCGTCCCACCCCCAGCGCACCTTT
TACCCACACCACCCCCAGATGTTGGGCTTCGATCCCAGGTGGATGATGATGCCTTCCTACATGGACCCACGTATCACGCCCACTCGGACC
CCGGTGGACTTCTACCCCTCCGCCCTGCATCCCTCAGGACTGATGAAGCCCATGATGCCCCAGGAGTCCCTCAATGGGACAGGCTGTCGC
TCTGAGGATCAGAACTGTGTGCCCCCACTCCAAGAAAGAAAAGTGACCCCCATCGACTCACCCCCTGTGTGGAGCCCAGAGGGCTACATG
GCACTGCAGAGCAAGGGCTACCCGCTCCCGCACCCGAAGTCGAGTGACACCTTGGCTATGGACATGCGTGTCAGATCCCCAGACGAGGCC
TTGCCTGGAGGTCTTAGTGGCTGCAGCAGTGGGAGTGGCCACTCCCCCTATGCCCTGGAGCGGGCAGCCCATGCCAGTGCTGACCTTCCC
GAAGCCTCCAGTAAAAAGGCAGAGAAGGAGGCCAAGTTGGCTGCTCCGAGGGCAGGTGAACAGGGAGAGGCCATGAAACAGTTTGACCTG
AACTATGGAAGTGCCATCATTGAAAATTGCGGGTCCAGCCCCGGGGAGGAGAGTGAGGTGGGTTCTATGGTGGGCGAAGGCTTCATCGAA
GTCCTGACCAAGAAGCAGCGCCGCCTGCTGGAGGAAGAGAGAAGAAAGAAGGAGCAGGCCGTGCAGGTGCCTGTCAAAGGTCGAGGCCTT
TCCTCCCGTATTCCTCCTCGATTTGCAAAAAAGCAGAACAACTTATGTCTGGAGCAAGGTGACGTGACCGTGCCTGGCAGCAGCCTGGGC
ACTGAGATCTGGGAGAGCAGCAGCCAGGCTCTCCCTGTGCAGGCCCCAGCCAACGACTCCTGGAGGAAAGCTGTCACTGCCTTCAGCAGC
ACCGAGACTGGCTCTGCGGAGCAGGGTTTTAAGAGCAGCCAGGGAGATAGTGGCGTTGACTTGAGTGCCGAGTCTCGGGAGTCGTCTGCG
ACCTCCTCGCAGCGCAGCTCCCCATATGGGACTCTGAAGCCAGAGGAGATGAGCGGGCCCGGCCTGGCGGAACCCAAGGCCGACAGCCAC
AAGGAGCAGGCTCCAAAGCCATCTGAGCAGAAGGATTCAGAACAAGGCTCTGGACAGAGCAAGGAGCACAGACCAGGACCCATCGGCAAC
GAGCGTTCTCTGAAAAACAGAAAGGGCTCGGAGGGGGCCGAGCGGCTGCAAGGGGCTGTCGTCCCGCCTGTTAACGGGGTGGAGATTCAC
GTGGACTCCGTGCTGCCTGTGCCACCCATTGAATTTGGAGTCAGTCCAAAAGACTCCGATTTCAGCTTGCCACCTGGTTCTGCCTCTGGT
CCTACTGGGAGTCCAGTTGTTAAACTTCAGGATGCCTTGGCCAGTAATCCCTGCTCCTGGACATCATGACGGTGGCCGGCGTGCAGAAGC
TCATCAAGCGGCGCGGCCCGTACGAGACGAGCCCCAGCCTCCTGGACTACCTCACCATGGACATCTACGCCTTCCCGGCCGGGCACGCCA
GCCGCGCCGCCATGGTGTCCAAGTTCTTCCTCAGCCACCTGGTGCTGGCGGTGCCCCTGCGTGTGCTGCTGGTGCTCTGGGCCCTCTGCG
TGGGCCTGTCCCGCGTGATGATCGGCCGCCACCACGTCACGGACGTCCTCTCCGGCTTTGTCATCGGCTACCTCCAGTTCCGTCTGGTGG
AGCTGGTCTGGATGCCCTCCAGCACCTGCCAGATGCTCATCTCTGCCTGGTGAAGCGCCCGCCGGCCCACACAAGCCTCTGGGGGCAGGG
CTGGCCCTAGAGAAGGGGCAGGGGGTGGCGAGGTGGCGGGCGTGGGTGGAACAGAGCGGCCAGGAGTCAGAGCGGCCACCCCCACCTCAT
CTTCCCCTCCTGGCTGGAGGCTGGCGAACCCAGGCCACCCCTCCCGGAGACAAGCGTGTTTGGCAGTGCCAGGCCTCTTGCCCCTTTGCT
TGGACTCCAAGTCTCCTCTCTAGGCAGCCAGGACCCACCCATGGGGACAGCCCTATTTAGCTTCTGCTCTGGGAACAGCAAAAATCAGGA
TGGTGGGAGGGGCCGAGTCTTGTCTTGTCCTTTCATCATCATGACTGTTGAGTTCTTGGCTGTGCCCATCACGCCACAGCACGACGCCTG
CCAAAATGCCCCCAACCTACTGCCTGATGCAGGTGCCATTGCCATTAGCGGTCATCGACAGCTTAGGGCAGCACTTTCCAACGGGTGCCC
ATGGGACACCAGCCTGCGAGATGCTTTTGGGGGAAAGGGGTTTTGTGGTTCAATAACTTTCGGAAGTGCTGCACACTCTGTCCCCAAGTT
GGACATTCACAAAGGCCGTTATTGCCGTAAAGGCTCTGACAAGCCCTATAGAAAAGCTTCTTGCTAAACCTTCTTTAACCCATGTTTTCT
AAACTTATTTGACCACAGAACCCTTTTCTTGGGGAACAGCTATTAACCCCCAAGGAATTATTGGTTCCTCAAGTGCGTTTTGGGAGCTGC
TGCCAGAGAGCTAAAGGGCCTGGGGTGTGAGCTGACTCTCCTCTGGGGAGGCCGGGTGCACACGCCACAGCCCGAGGAAAGTGCTGGCCA
CCGCCCGTGGGCATCGATGAGGCTTTGGCCCCCAGGGGCCGGACTCCGTGTGACCTAATAGGTCGTTTCCAAGTCACCCGTTTTGGATGT

>69228_69228_3_PRRC2B-PPAPDC3_PRRC2B_chr9_134358832_ENST00000458550_PPAPDC3_chr9_134183310_ENST00000372264_length(amino acids)=1132AA_BP=
MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANK
QDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG
QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMG
NVYHPPTYHDMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG
LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPD
PQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR
KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQR
QQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR
SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRSPDEALPGGLSGCSSGSGHSPYALERAAHASADLP
EASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGL
SSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSA
TSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRRC2B-PPAPDC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePPAPDC3chr9:134358832chr9:134183310ENST000003722640270_91150.33333333333334272.0MTOR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRRC2B-PPAPDC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRRC2B-PPAPDC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource