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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASAH1-ANKZF1 (FusionGDB2 ID:6930)

Fusion Gene Summary for ASAH1-ANKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAH1-ANKZF1
Fusion gene ID: 6930
HgeneTgene
Gene symbol

ASAH1

ANKZF1

Gene ID

427

55139

Gene nameN-acylsphingosine amidohydrolase 1ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
SynonymsAC|ACDase|ASAH|PHP|PHP32|SMAPMEVms1|ZNF744
Cytomap

8p22

2q35

Type of geneprotein-codingprotein-coding
Descriptionacid ceramidaseN-acylethanolamine hydrolase ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart proteinankyrin repeat and zinc finger domain-containing protein 1ankyrin repeat and zinc finger domain containing 1zinc finger protein 744
Modification date2020031320200313
UniProtAcc

Q13510

.
Ensembl transtripts involved in fusion geneENST00000262097, ENST00000314146, 
ENST00000381733, ENST00000417108, 
ENST00000520051, ENST00000520781, 
ENST00000323348, ENST00000409849, 
ENST00000410034, 
Fusion gene scores* DoF score15 X 16 X 7=16804 X 4 X 3=48
# samples 164
** MAII scorelog2(16/1680*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAH1 [Title/Abstract] AND ANKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASAH1(17921965)-ANKZF1(220099547), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASAH1

GO:0046512

sphingosine biosynthetic process

12815059

HgeneASAH1

GO:0046513

ceramide biosynthetic process

12764132|12815059

HgeneASAH1

GO:0046514

ceramide catabolic process

12815059


check buttonFusion gene breakpoints across ASAH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKZF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EQASAH1chr8

17921965

-ANKZF1chr2

220099547

+


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Fusion Gene ORF analysis for ASAH1-ANKZF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262097ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000262097ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000262097ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000314146ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000314146ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000314146ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000381733ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000381733ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
In-frameENST00000381733ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000417108ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000417108ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000417108ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520051ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520051ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520051ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520781ENST00000323348ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520781ENST00000409849ASAH1chr8

17921965

-ANKZF1chr2

220099547

+
intron-3CDSENST00000520781ENST00000410034ASAH1chr8

17921965

-ANKZF1chr2

220099547

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262097ASAH1chr817921965-ENST00000323348ANKZF1chr2220099547+1970769151745576
ENST00000262097ASAH1chr817921965-ENST00000409849ANKZF1chr2220099547+1970769151745576
ENST00000262097ASAH1chr817921965-ENST00000410034ANKZF1chr2220099547+1950769151745576
ENST00000381733ASAH1chr817921965-ENST00000323348ANKZF1chr2220099547+187367251648547
ENST00000381733ASAH1chr817921965-ENST00000409849ANKZF1chr2220099547+187367251648547
ENST00000381733ASAH1chr817921965-ENST00000410034ANKZF1chr2220099547+185367251648547
ENST00000314146ASAH1chr817921965-ENST00000323348ANKZF1chr2220099547+1824623221599525
ENST00000314146ASAH1chr817921965-ENST00000409849ANKZF1chr2220099547+1824623221599525
ENST00000314146ASAH1chr817921965-ENST00000410034ANKZF1chr2220099547+1804623221599525

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262097ENST00000323348ASAH1chr817921965-ANKZF1chr2220099547+0.0107159420.989284
ENST00000262097ENST00000409849ASAH1chr817921965-ANKZF1chr2220099547+0.0107159420.989284
ENST00000262097ENST00000410034ASAH1chr817921965-ANKZF1chr2220099547+0.0115714110.98842865
ENST00000381733ENST00000323348ASAH1chr817921965-ANKZF1chr2220099547+0.0345531630.9654468
ENST00000381733ENST00000409849ASAH1chr817921965-ANKZF1chr2220099547+0.0345531630.9654468
ENST00000381733ENST00000410034ASAH1chr817921965-ANKZF1chr2220099547+0.0380564370.9619436
ENST00000314146ENST00000323348ASAH1chr817921965-ANKZF1chr2220099547+0.040326520.9596735
ENST00000314146ENST00000409849ASAH1chr817921965-ANKZF1chr2220099547+0.040326520.9596735
ENST00000314146ENST00000410034ASAH1chr817921965-ANKZF1chr2220099547+0.0444026960.95559734

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Fusion Genomic Features for ASAH1-ANKZF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASAH1chr817921965-ANKZF1chr2220099547+0.99923740.00076265
ASAH1chr817921965-ANKZF1chr2220099547+0.99923740.00076265

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASAH1-ANKZF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17921965/chr2:220099547)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAH1

Q13510

.
FUNCTION: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:7744740, PubMed:15655246). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Has also an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821). {ECO:0000250|UniProtKB:Q9WV54, ECO:0000269|PubMed:10610716, ECO:0000269|PubMed:11451951, ECO:0000269|PubMed:12764132, ECO:0000269|PubMed:12815059, ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:22261821, ECO:0000269|PubMed:7744740, ECO:0000303|PubMed:10610716}.; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. {ECO:0000305|PubMed:22927646}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKZF1chr8:17921965chr2:220099547ENST00000323348814609_659401727.0Coiled coilOntology_term=ECO:0000255
TgeneANKZF1chr8:17921965chr2:220099547ENST00000410034814609_659401727.0Coiled coilOntology_term=ECO:0000255
TgeneANKZF1chr8:17921965chr2:220099547ENST00000323348814654_666401727.0RegionVCP/p97-interacting motif (VIM)
TgeneANKZF1chr8:17921965chr2:220099547ENST00000410034814654_666401727.0RegionVCP/p97-interacting motif (VIM)
TgeneANKZF1chr8:17921965chr2:220099547ENST00000323348814493_526401727.0RepeatNote=ANK 1
TgeneANKZF1chr8:17921965chr2:220099547ENST00000323348814534_563401727.0RepeatNote=ANK 2
TgeneANKZF1chr8:17921965chr2:220099547ENST00000410034814493_526401727.0RepeatNote=ANK 1
TgeneANKZF1chr8:17921965chr2:220099547ENST00000410034814534_563401727.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKZF1chr8:17921965chr2:220099547ENST0000032334881472_96401727.0Zinc fingerNote=C2H2-type
TgeneANKZF1chr8:17921965chr2:220099547ENST0000041003481472_96401727.0Zinc fingerNote=C2H2-type


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Fusion Gene Sequence for ASAH1-ANKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6930_6930_1_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000323348_length(transcript)=1970nt_BP=769nt
GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC
TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT
CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT
GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC
AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCA
GTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATA
GTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGC
AACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTT
TATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTG
GAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAG
AAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTT
GCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGA
GATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGC
TTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGAC
TCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTAC
GATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGG
CGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGA
GAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACT
CGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAG
GATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACA
GCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGC

>6930_6930_1_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000323348_length(amino acids)=576AA_BP=251
MPAVGEGDGSRHAPKAIATLLLQVAWKALSLSLRHPFRGTEKPRPLLPVPPPPSVPPTAWNGAVPGRGSRGGGGVACPRPSRLFFASAGV
RGVALAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLK
NMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVEL
TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVL
KLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWS

--------------------------------------------------------------
>6930_6930_2_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000409849_length(transcript)=1970nt_BP=769nt
GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC
TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT
CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT
GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC
AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCA
GTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATA
GTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGC
AACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTT
TATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTG
GAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAG
AAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTT
GCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGA
GATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGC
TTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGAC
TCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTAC
GATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGG
CGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGA
GAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACT
CGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAG
GATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACA
GCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGC

>6930_6930_2_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000409849_length(amino acids)=576AA_BP=251
MPAVGEGDGSRHAPKAIATLLLQVAWKALSLSLRHPFRGTEKPRPLLPVPPPPSVPPTAWNGAVPGRGSRGGGGVACPRPSRLFFASAGV
RGVALAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLK
NMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVEL
TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVL
KLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWS

--------------------------------------------------------------
>6930_6930_3_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000410034_length(transcript)=1950nt_BP=769nt
GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC
TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT
CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT
GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC
AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCA
GTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATA
GTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGC
AACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTT
TATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTG
GAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAG
AAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTT
GCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGA
GATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGC
TTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGAC
TCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTAC
GATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGG
CGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGA
GAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACT
CGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAG
GATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACA
GCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGC

>6930_6930_3_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000262097_ANKZF1_chr2_220099547_ENST00000410034_length(amino acids)=576AA_BP=251
MPAVGEGDGSRHAPKAIATLLLQVAWKALSLSLRHPFRGTEKPRPLLPVPPPPSVPPTAWNGAVPGRGSRGGGGVACPRPSRLFFASAGV
RGVALAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLK
NMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVEL
TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVL
KLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWS

--------------------------------------------------------------
>6930_6930_4_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000323348_length(transcript)=1824nt_BP=623nt
GGGCAGGATTTCCTGCTGGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCC
CCCTGCCGAGCTACTCGCGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCG
CTTAATGAACTGCTGCATCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGC
CTCAATTCTGGGATTTGGCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTGT
CTTCCCTGCTGTTATAAGGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGAT
GCTTGACAAGGCACCAGTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATAT
ACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGG
GTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCC
CAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGA
AGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCT
CTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCT
GTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCT
GCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTT
CCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCA
GGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGA
AGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTAC
CTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCT
CGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGG
GGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGT
GAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGC

>6930_6930_4_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000323348_length(amino acids)=525AA_BP=200
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTVFPAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIPLGEIIS
FNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQS
SQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADP
TVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAA

--------------------------------------------------------------
>6930_6930_5_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000409849_length(transcript)=1824nt_BP=623nt
GGGCAGGATTTCCTGCTGGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCC
CCCTGCCGAGCTACTCGCGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCG
CTTAATGAACTGCTGCATCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGC
CTCAATTCTGGGATTTGGCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTGT
CTTCCCTGCTGTTATAAGGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGAT
GCTTGACAAGGCACCAGTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATAT
ACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGG
GTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCC
CAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGA
AGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCT
CTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCT
GTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCT
GCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTT
CCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCA
GGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGA
AGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTAC
CTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCT
CGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGG
GGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGT
GAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGC

>6930_6930_5_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000409849_length(amino acids)=525AA_BP=200
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTVFPAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIPLGEIIS
FNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQS
SQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADP
TVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAA

--------------------------------------------------------------
>6930_6930_6_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000410034_length(transcript)=1804nt_BP=623nt
GGGCAGGATTTCCTGCTGGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCC
CCCTGCCGAGCTACTCGCGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCG
CTTAATGAACTGCTGCATCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGC
CTCAATTCTGGGATTTGGCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTGT
CTTCCCTGCTGTTATAAGGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGAT
GCTTGACAAGGCACCAGTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATAT
ACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGG
GTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCC
CAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGA
AGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCT
CTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCT
GTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCT
GCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTT
CCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCA
GGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGA
AGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTAC
CTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCT
CGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGG
GGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGT
GAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGC

>6930_6930_6_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000314146_ANKZF1_chr2_220099547_ENST00000410034_length(amino acids)=525AA_BP=200
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTVFPAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIPLGEIIS
FNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQS
SQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADP
TVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAA

--------------------------------------------------------------
>6930_6930_7_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000323348_length(transcript)=1873nt_BP=672nt
GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCG
CGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCA
TCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTG
GCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCAT
GGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAATT
CTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGCAACTTTC
CTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAAT
TATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAG
TGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCC
GAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCC
CCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTG
GAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTC
TCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGG
CCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACA
ACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAAC
GGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGA
GAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCT
GCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATC
GCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCC
TAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGT

>6930_6930_7_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000323348_length(amino acids)=547AA_BP=222
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPG
PFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD
QEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLL
HAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQRE
EQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRR

--------------------------------------------------------------
>6930_6930_8_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000409849_length(transcript)=1873nt_BP=672nt
GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCG
CGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCA
TCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTG
GCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCAT
GGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAATT
CTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGCAACTTTC
CTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAAT
TATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAG
TGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCC
GAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCC
CCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTG
GAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTC
TCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGG
CCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACA
ACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAAC
GGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGA
GAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCT
GCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATC
GCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCC
TAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGT

>6930_6930_8_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000409849_length(amino acids)=547AA_BP=222
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPG
PFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD
QEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLL
HAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQRE
EQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRR

--------------------------------------------------------------
>6930_6930_9_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000410034_length(transcript)=1853nt_BP=672nt
GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCG
CGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCA
TCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTG
GCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCAT
GGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAATT
CTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGCAACTTTC
CTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAAT
TATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTTCAGGGTCGGAGGGAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAG
TGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCC
GAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCATCCCAGGCAGTTGCTGCCC
CCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCTTGCCGAGCTGGAGATGTTG
GAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTC
TCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCCACTGTGCAGGACTCTCGGG
CCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAATCCAGATGCCTACGATTACA
ACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAAC
GGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCCCTCAGTGACCGAGAGAAGA
GAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCAATCGTCAATACTCGACGCT
GCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACACGTTGCCTCCAGGATCATC
GCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAGGGCACATTCACAGCAGCCC
TAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGGCAAAGACAGGGCTAGAGGT

>6930_6930_9_ASAH1-ANKZF1_ASAH1_chr8_17921965_ENST00000381733_ANKZF1_chr2_220099547_ENST00000410034_length(amino acids)=547AA_BP=222
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPG
PFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD
QEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLL
HAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQRE
EQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRR

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Fusion Gene PPI Analysis for ASAH1-ANKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASAH1-ANKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASAH1-ANKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource