FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRSS3-KLK6 (FusionGDB2 ID:69322)

Fusion Gene Summary for PRSS3-KLK6

check button Fusion gene summary
Fusion gene informationFusion gene name: PRSS3-KLK6
Fusion gene ID: 69322
HgeneTgene
Gene symbol

PRSS3

KLK6

Gene ID

5646

5653

Gene nameserine protease 3kallikrein related peptidase 6
SynonymsMTG|PRSS4|T9|TRY3|TRY4Bssp|Klk7|PRSS18|PRSS9|SP59|hK6
Cytomap

9p13.3

19q13.41

Type of geneprotein-codingprotein-coding
Descriptiontrypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IVkallikrein-6kallikrein 6neurosinprotease Mserine protease 18serine protease 9zyme
Modification date2020031320200313
UniProtAcc.

Q92876

Ensembl transtripts involved in fusion geneENST00000495682, ENST00000342836, 
ENST00000361005, ENST00000379405, 
ENST00000429677, 		ENST00000310157, 
ENST00000376851, ENST00000376853, 
ENST00000391808, ENST00000456750, 
ENST00000594641, ENST00000424910, 
Fusion gene scores* DoF score7 X 4 X 4=1125 X 3 X 4=60
# samples 87
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRSS3 [Title/Abstract] AND KLK6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRSS3(33798620)-KLK6(51462572), # samples:2
Anticipated loss of major functional domain due to fusion event.PRSS3-KLK6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRSS3-KLK6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PRSS3-KLK6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRSS3-KLK6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRSS3

GO:0006508

proteolysis

6698368|11827488

HgenePRSS3

GO:0031638

zymogen activation

6698368

TgeneKLK6

GO:0045745

positive regulation of G protein-coupled receptor signaling pathway

16885167


check buttonFusion gene breakpoints across PRSS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLK6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CM-6171-01APRSS3chr9

33798620

+KLK6chr19

51462572

-
ChimerDB4THCATCGA-DJ-A4UL-01APRSS3chr9

33798620

+KLK6chr19

51462572

-


Top

Fusion Gene ORF analysis for PRSS3-KLK6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000495682ENST00000310157PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-3CDSENST00000495682ENST00000376851PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-3CDSENST00000495682ENST00000376853PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-3CDSENST00000495682ENST00000391808PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-3CDSENST00000495682ENST00000456750PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-3CDSENST00000495682ENST00000594641PRSS3chr9

33798620

+KLK6chr19

51462572

-
3UTR-intronENST00000495682ENST00000424910PRSS3chr9

33798620

+KLK6chr19

51462572

-
5CDS-intronENST00000342836ENST00000424910PRSS3chr9

33798620

+KLK6chr19

51462572

-
5CDS-intronENST00000361005ENST00000424910PRSS3chr9

33798620

+KLK6chr19

51462572

-
5CDS-intronENST00000379405ENST00000424910PRSS3chr9

33798620

+KLK6chr19

51462572

-
5CDS-intronENST00000429677ENST00000424910PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000342836ENST00000310157PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000342836ENST00000376851PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000342836ENST00000376853PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000342836ENST00000391808PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000342836ENST00000456750PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000361005ENST00000310157PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000361005ENST00000376851PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000361005ENST00000376853PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000361005ENST00000391808PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000361005ENST00000456750PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000379405ENST00000310157PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000379405ENST00000376851PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000379405ENST00000376853PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000379405ENST00000391808PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000379405ENST00000456750PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000429677ENST00000310157PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000429677ENST00000376851PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000429677ENST00000376853PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000429677ENST00000391808PRSS3chr9

33798620

+KLK6chr19

51462572

-
Frame-shiftENST00000429677ENST00000456750PRSS3chr9

33798620

+KLK6chr19

51462572

-
In-frameENST00000342836ENST00000594641PRSS3chr9

33798620

+KLK6chr19

51462572

-
In-frameENST00000361005ENST00000594641PRSS3chr9

33798620

+KLK6chr19

51462572

-
In-frameENST00000379405ENST00000594641PRSS3chr9

33798620

+KLK6chr19

51462572

-
In-frameENST00000429677ENST00000594641PRSS3chr9

33798620

+KLK6chr19

51462572

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361005PRSS3chr933798620+ENST00000594641KLK6chr1951462572-9307620914304
ENST00000342836PRSS3chr933798620+ENST00000594641KLK6chr1951462572-88571784869261
ENST00000429677PRSS3chr933798620+ENST00000594641KLK6chr1951462572-75158313735240
ENST00000379405PRSS3chr933798620+ENST00000594641KLK6chr1951462572-79863039782247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361005ENST00000594641PRSS3chr933798620+KLK6chr1951462572-0.0232291130.9767709
ENST00000342836ENST00000594641PRSS3chr933798620+KLK6chr1951462572-0.003405730.99659425
ENST00000429677ENST00000594641PRSS3chr933798620+KLK6chr1951462572-0.0050761470.9949239
ENST00000379405ENST00000594641PRSS3chr933798620+KLK6chr1951462572-0.0037618990.9962381

Top

Fusion Genomic Features for PRSS3-KLK6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PRSS3-KLK6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33798620/chr19:51462572)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KLK6

Q92876

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLK6chr9:33798620chr19:51462572ENST000004249100222_242041.0DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRSS3chr9:33798620chr19:51462572ENST00000342836+5681_301211262.0DomainPeptidase S1
HgenePRSS3chr9:33798620chr19:51462572ENST00000361005+4581_301254305.0DomainPeptidase S1
HgenePRSS3chr9:33798620chr19:51462572ENST00000379405+4581_301197248.0DomainPeptidase S1
TgeneKLK6chr9:33798620chr19:51462572ENST000003101575722_242194245.0DomainPeptidase S1
TgeneKLK6chr9:33798620chr19:51462572ENST000003768514622_242194245.0DomainPeptidase S1
TgeneKLK6chr9:33798620chr19:51462572ENST000003918083522_24287138.0DomainPeptidase S1
TgeneKLK6chr9:33798620chr19:51462572ENST000004567501322_24287138.0DomainPeptidase S1
TgeneKLK6chr9:33798620chr19:51462572ENST000005946413522_242194245.0DomainPeptidase S1


Top

Fusion Gene Sequence for PRSS3-KLK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69322_69322_1_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000342836_KLK6_chr19_51462572_ENST00000594641_length(transcript)=885nt_BP=717nt
GGCGCGGGATGCAGACGGCTGCGAGGCGCTGGGCACAGGTTGCCAGGACAACCGTGAGGCTGCATAAAAAGAACCTATGACAGGATGCAC
ATGAGAGAGACAAGTGGCTTCACATTGAAGAAGGGGAGGAGTGCGCCATTGGTTTTCCATCCTCCAGATGCACTGATTGCTGTCCCCTTT
GACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGC
GGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATC
AAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATC
ATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAG
TGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAG
GCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGGGT
GATTCTGGGGGTCCGCTGGTATGTGGAGACCACCTCCGAGGCCTTGTGTCATGGGGTAACATCCCCTGTGGATCAAAGGAGAAGCCAGGA

>69322_69322_1_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000342836_KLK6_chr19_51462572_ENST00000594641_length(amino acids)=261AA_BP=145
MHMRETSGFTLKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEH
NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVL

--------------------------------------------------------------
>69322_69322_2_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000361005_KLK6_chr19_51462572_ENST00000594641_length(transcript)=930nt_BP=762nt
ATGTGCGGACCTGACGACAGATGCCCCGCACGCTGGCCGGGACCGGGAAGGGCGGTCAAGTGTGGAAAGGGTCTGGCGGCTGCCAGGCCT
GGCAGAGTGGAGCGGGGCGGGGCGCAGCGGGGCGGGGCGGGCCTGGAGCTGCACCCGCTTCTGGGTGGACGCACTTGGCGAGCGGCGCGG
GATGCAGACGGCTGCGAGGCGCTGGGCACAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAAT
TCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCAC
TGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATC
ATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTG
TCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCTGAC
TACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCAACAGCATG
TTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCGCTGGTATGTGGAGACCACCTCCGAGGCCTT
GTGTCATGGGGTAACATCCCCTGTGGATCAAAGGAGAAGCCAGGAGTCTACACCAACGTCTGCAGATACACGAACTGGATCCAAAAAACC

>69322_69322_2_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000361005_KLK6_chr19_51462572_ENST00000594641_length(amino acids)=304AA_BP=188
MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEEN
SLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQGDSGGPLVCGDHLRGL

--------------------------------------------------------------
>69322_69322_3_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000379405_KLK6_chr19_51462572_ENST00000594641_length(transcript)=798nt_BP=630nt
GACAGGCCTTCCACCACCAGTCAGGCACACTCTACCACCATGAATCCATTCCTGATCCTTGCCTTTGTGGGAGCTGCTGTTGCTGTCCCC
TTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTC
TGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAAC
ATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGAC
ATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACT
GAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACC
CAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAG
GGTGATTCTGGGGGTCCGCTGGTATGTGGAGACCACCTCCGAGGCCTTGTGTCATGGGGTAACATCCCCTGTGGATCAAAGGAGAAGCCA

>69322_69322_3_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000379405_KLK6_chr19_51462572_ENST00000594641_length(amino acids)=247AA_BP=131
MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINA
AKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKIT

--------------------------------------------------------------
>69322_69322_4_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000429677_KLK6_chr19_51462572_ENST00000594641_length(transcript)=751nt_BP=583nt
GGTTCCGACTCGCATGGGACCTGCGGGGGAGGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAA
TTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCA
CTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGAT
CATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGT
GTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCTGA
CTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCAACAGCAT
GTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCGCTGGTATGTGGAGACCACCTCCGAGGCCT
TGTGTCATGGGGTAACATCCCCTGTGGATCAAAGGAGAAGCCAGGAGTCTACACCAACGTCTGCAGATACACGAACTGGATCCAAAAAAC

>69322_69322_4_PRSS3-KLK6_PRSS3_chr9_33798620_ENST00000429677_KLK6_chr19_51462572_ENST00000594641_length(amino acids)=240AA_BP=124
MGPAGEVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHP
KYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRSS3-KLK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRSS3-KLK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRSS3-KLK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource