FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRUNE-VPS45 (FusionGDB2 ID:69368)

Fusion Gene Summary for PRUNE-VPS45

check button Fusion gene summary
Fusion gene informationFusion gene name: PRUNE-VPS45
Fusion gene ID: 69368
HgeneTgene
Gene symbol

PRUNE

VPS45

Gene ID

58497

11311

Gene nameprune exopolyphosphatase 1vacuolar protein sorting 45 homolog
SynonymsDRES-17|DRES17|H-PRUNE|HTCD37|NMIHBA|PRUNEH1|H1VPS45|SCN5|VPS45A|VPS45B|VPS54A|VSP45|VSP45A
Cytomap

1q21.3

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionexopolyphosphatase PRUNE1Drosophila-related expressed sequence 17protein prune homologprotein prune homolog 1vacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000467771, ENST00000271620, 
ENST00000368936, ENST00000271619, 
ENST00000368934, ENST00000368935, 
ENST00000368937, 		ENST00000369128, 
ENST00000369130, ENST00000484306, 
ENST00000535106, 
Fusion gene scores* DoF score7 X 5 X 6=2108 X 7 X 6=336
# samples 810
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRUNE [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRUNE(151001420)-VPS45(150116886), # samples:1
PRUNE(151001420)-VPS45(150116887), # samples:1
Anticipated loss of major functional domain due to fusion event.PRUNE-VPS45 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PRUNE-VPS45 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRUNE-VPS45 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PRUNE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VPS45 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2019-01APRUNEchr1

151001420

+VPS45chr1

150116887

+
ChimerDB4OVTCGA-24-2019PRUNEchr1

151001420

+VPS45chr1

150116886

+


Top

Fusion Gene ORF analysis for PRUNE-VPS45

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000467771ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
3UTR-3CDSENST00000467771ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
3UTR-3CDSENST00000467771ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
3UTR-3CDSENST00000467771ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
3UTR-3UTRENST00000467771ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
3UTR-3UTRENST00000467771ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
3UTR-3UTRENST00000467771ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
3UTR-3UTRENST00000467771ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
5CDS-3UTRENST00000271620ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
5CDS-3UTRENST00000271620ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
5CDS-3UTRENST00000271620ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
5CDS-3UTRENST00000271620ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
5CDS-3UTRENST00000368936ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
5CDS-3UTRENST00000368936ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
5CDS-3UTRENST00000368936ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
5CDS-3UTRENST00000368936ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
Frame-shiftENST00000271620ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
Frame-shiftENST00000271620ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
Frame-shiftENST00000368936ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
Frame-shiftENST00000368936ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
In-frameENST00000271620ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
In-frameENST00000271620ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
In-frameENST00000368936ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
In-frameENST00000368936ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000271619ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000271619ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000271619ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000271619ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368934ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368934ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368934ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368934ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368935ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368935ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368935ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368935ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368937ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368937ENST00000369128PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3CDSENST00000368937ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3CDSENST00000368937ENST00000369130PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000271619ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000271619ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000271619ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000271619ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368934ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368934ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368934ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368934ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368935ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368935ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368935ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368935ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368937ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368937ENST00000484306PRUNEchr1

151001420

+VPS45chr1

150116886

+
intron-3UTRENST00000368937ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116887

+
intron-3UTRENST00000368937ENST00000535106PRUNEchr1

151001420

+VPS45chr1

150116886

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000271620PRUNEchr1151001420+ENST00000369130VPS45chr1150116886+17081089601301413
ENST00000368936PRUNEchr1151001420+ENST00000369130VPS45chr1150116886+14998803761092238
ENST00000271620PRUNEchr1151001420+ENST00000369130VPS45chr1150116887+17081089601301413
ENST00000368936PRUNEchr1151001420+ENST00000369130VPS45chr1150116887+14998803761092238

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000271620ENST00000369130PRUNEchr1151001420+VPS45chr1150116886+0.0005846860.9994153
ENST00000368936ENST00000369130PRUNEchr1151001420+VPS45chr1150116886+0.0047743270.99522567
ENST00000271620ENST00000369130PRUNEchr1151001420+VPS45chr1150116887+0.0005846860.9994153
ENST00000368936ENST00000369130PRUNEchr1151001420+VPS45chr1150116887+0.0047743270.99522567

Top

Fusion Genomic Features for PRUNE-VPS45


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRUNEchr1151001420+VPS45chr1150116886+0.0001303950.9998696
PRUNEchr1151001420+VPS45chr1150116886+0.0001303950.9998696
PRUNEchr1151001420+VPS45chr1150116886+0.0001303950.9998696
PRUNEchr1151001420+VPS45chr1150116886+0.0001303950.9998696

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PRUNE-VPS45


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:151001420/chr1:150116886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRUNEchr1:151001420chr1:150116886ENST00000271620+78106_108311454.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116886ENST00000368936+67106_108129272.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116887ENST00000271620+78106_108311454.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116887ENST00000368936+67106_108129272.0MotifNote=DHH motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRUNEchr1:151001420chr1:150116886ENST00000368934+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116886ENST00000368935+14106_1080169.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116886ENST00000368937+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116887ENST00000368934+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116887ENST00000368935+14106_1080169.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116887ENST00000368937+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:151001420chr1:150116886ENST00000271620+78393_420311454.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116886ENST00000368934+14393_4200219.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116886ENST00000368935+14393_4200169.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116886ENST00000368936+67393_420129272.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116886ENST00000368937+14393_4200219.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116887ENST00000271620+78393_420311454.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116887ENST00000368934+14393_4200219.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116887ENST00000368935+14393_4200169.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116887ENST00000368936+67393_420129272.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:151001420chr1:150116887ENST00000368937+14393_4200219.0RegionNote=Essential for homodimerization


Top

Fusion Gene Sequence for PRUNE-VPS45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69368_69368_1_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000271620_VPS45_chr1_150116886_ENST00000369130_length(transcript)=1708nt_BP=1089nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAAAGTGACACAGCCCTAGAGGAGGCAGTAGCAGAGGTGCTAGACCATCGA
CCCATCGAGCCGAAACACTGCCCTCCCTGCCATGTTTCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAG
GGGGCACCAGAGATCTTGGACAGGCAAACTGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGTGTCAACATGGACCTTAAAATTGGA
AAGGCAACCCCAAAGGACAGCAAATATGTGGAGAAACTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTA
CAAAAGGCAAAGTTTGATGTATCAGGACTGACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACTATCTATAGACAAGGCGTCAAGGTG
GCCATTAGTGCAATATATATGGATTTGGAGGCCTTTCTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGC
TATGATGTCCTGGTTGCCATGACTATCTTTTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCTATTTTCTGTCCCCATGTGGCACTC
CAAACAACGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAG
AAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAG
CTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCT
AACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTT
GTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCC
TTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCA

>69368_69368_1_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000271620_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=413AA_BP=338
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEAVAEVLDHRPIEPKHCPPCHVSVELVGSC
ATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQ
KTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTFPRGSSGFWTAQPKQGE

--------------------------------------------------------------
>69368_69368_2_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000271620_VPS45_chr1_150116887_ENST00000369130_length(transcript)=1708nt_BP=1089nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAAAGTGACACAGCCCTAGAGGAGGCAGTAGCAGAGGTGCTAGACCATCGA
CCCATCGAGCCGAAACACTGCCCTCCCTGCCATGTTTCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAG
GGGGCACCAGAGATCTTGGACAGGCAAACTGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGTGTCAACATGGACCTTAAAATTGGA
AAGGCAACCCCAAAGGACAGCAAATATGTGGAGAAACTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTA
CAAAAGGCAAAGTTTGATGTATCAGGACTGACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACTATCTATAGACAAGGCGTCAAGGTG
GCCATTAGTGCAATATATATGGATTTGGAGGCCTTTCTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGC
TATGATGTCCTGGTTGCCATGACTATCTTTTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCTATTTTCTGTCCCCATGTGGCACTC
CAAACAACGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAG
AAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAG
CTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCT
AACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTT
GTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCC
TTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCA

>69368_69368_2_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000271620_VPS45_chr1_150116887_ENST00000369130_length(amino acids)=413AA_BP=338
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEAVAEVLDHRPIEPKHCPPCHVSVELVGSC
ATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQ
KTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTFPRGSSGFWTAQPKQGE

--------------------------------------------------------------
>69368_69368_3_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000368936_VPS45_chr1_150116886_ENST00000369130_length(transcript)=1499nt_BP=880nt
CGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGGGAAACC
TCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGTCGAGCT
GCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTGGCTTTT
TACCTAGCAAAGAAGTGACACAGCCCTAGAGGAGGCAGTAGCAGAGGTGCTAGACCATCGACCCATCGAGCCGAAACACTGCCCTCCCTG
CCATGTTTCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAGGGGGCACCAGAGATCTTGGACAGGCAAAC
TGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGTGTCAACATGGACCTTAAAATTGGAAAGGCAACCCCAAAGGACAGCAAATATGT
GGAGAAACTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTACAAAAGGCAAAGTTTGATGTATCAGGACT
GACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACTATCTATAGACAAGGCGTCAAGGTGGCCATTAGTGCAATATATATGGATTTGGA
GGCCTTTCTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGCTATGATGTCCTGGTTGCCATGACTATCTT
TTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCTATTTTCTGTCCCCATGTGGCACTCCAAACAACGTTTCCTAGAGGAAGTTCTGG
CTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCA
CAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACT
CATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCA
CTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTAT
CAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTT
CATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAA

>69368_69368_3_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000368936_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=238AA_BP=163
MVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQM
LRKDQKTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTFPRGSSGFWTAQ

--------------------------------------------------------------
>69368_69368_4_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000368936_VPS45_chr1_150116887_ENST00000369130_length(transcript)=1499nt_BP=880nt
CGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGGGAAACC
TCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGTCGAGCT
GCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTGGCTTTT
TACCTAGCAAAGAAGTGACACAGCCCTAGAGGAGGCAGTAGCAGAGGTGCTAGACCATCGACCCATCGAGCCGAAACACTGCCCTCCCTG
CCATGTTTCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAGGGGGCACCAGAGATCTTGGACAGGCAAAC
TGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGTGTCAACATGGACCTTAAAATTGGAAAGGCAACCCCAAAGGACAGCAAATATGT
GGAGAAACTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTACAAAAGGCAAAGTTTGATGTATCAGGACT
GACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACTATCTATAGACAAGGCGTCAAGGTGGCCATTAGTGCAATATATATGGATTTGGA
GGCCTTTCTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGCTATGATGTCCTGGTTGCCATGACTATCTT
TTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCTATTTTCTGTCCCCATGTGGCACTCCAAACAACGTTTCCTAGAGGAAGTTCTGG
CTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCA
CAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACT
CATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCA
CTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTAT
CAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTT
CATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAA

>69368_69368_4_PRUNE-VPS45_PRUNE_chr1_151001420_ENST00000368936_VPS45_chr1_150116887_ENST00000369130_length(amino acids)=238AA_BP=163
MVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQM
LRKDQKTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTFPRGSSGFWTAQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRUNE-VPS45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRUNE-VPS45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRUNE-VPS45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource