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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PSAP-ABCA1 (FusionGDB2 ID:69374) |
Fusion Gene Summary for PSAP-ABCA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSAP-ABCA1 | Fusion gene ID: 69374 | Hgene | Tgene | Gene symbol | PSAP | ABCA1 | Gene ID | 729238 | 19 |
| Gene name | surfactant protein A2 | ATP binding cassette subfamily A member 1 | |
| Synonyms | COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAII | ABC-1|ABC1|CERP|HDLCQTL13|HDLDT1|HPALP1|TGD | |
| Cytomap | 10q22.3 | 9q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pulmonary surfactant-associated protein A235 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5surfactant, pulmonary-associated protein A2A | phospholipid-transporting ATPase ABCA1ATP-binding cassette sub-family A member 1ATP-binding cassette transporter A1ATP-binding cassette, sub-family A (ABC1), member 1cholesterol efflux regulatory proteinmembrane-bound | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q86UQ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000394934, ENST00000394936, | ENST00000374733, ENST00000423487, ENST00000494467, ENST00000374736, | |
| Fusion gene scores | * DoF score | 46 X 32 X 14=20608 | 3 X 3 X 3=27 |
| # samples | 52 | 3 | |
| ** MAII score | log2(52/20608*10)=-5.30854906508616 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PSAP [Title/Abstract] AND ABCA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PSAP(73576058)-ABCA1(107567001), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ABCA1 | GO:0007040 | lysosome organization | 15163665 |
| Tgene | ABCA1 | GO:0008203 | cholesterol metabolic process | 14747463 |
| Tgene | ABCA1 | GO:0016197 | endosomal transport | 14747463 |
| Tgene | ABCA1 | GO:0033344 | cholesterol efflux | 10431236|11162594|16702602|23931754 |
| Tgene | ABCA1 | GO:0033700 | phospholipid efflux | 10431236|11162594 |
| Tgene | ABCA1 | GO:0042632 | cholesterol homeostasis | 10431236 |
| Tgene | ABCA1 | GO:0045332 | phospholipid translocation | 24097981 |
| Fusion gene breakpoints across PSAP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ABCA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-EB-A44Q-06A | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
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Fusion Gene ORF analysis for PSAP-ABCA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000394934 | ENST00000374733 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| 5CDS-intron | ENST00000394934 | ENST00000423487 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| 5CDS-intron | ENST00000394934 | ENST00000494467 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| 5CDS-intron | ENST00000394936 | ENST00000374733 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| 5CDS-intron | ENST00000394936 | ENST00000423487 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| 5CDS-intron | ENST00000394936 | ENST00000494467 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| In-frame | ENST00000394934 | ENST00000374736 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| In-frame | ENST00000394936 | ENST00000374736 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000394936 | PSAP | chr10 | 73576058 | - | ENST00000374736 | ABCA1 | chr9 | 107567001 | - | 8501 | 2866 | 2854 | 5187 | 777 |
| ENST00000394934 | PSAP | chr10 | 73576058 | - | ENST00000374736 | ABCA1 | chr9 | 107567001 | - | 8460 | 2825 | 2816 | 5146 | 776 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000394936 | ENST00000374736 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - | 0.000574974 | 0.99942505 |
| ENST00000394934 | ENST00000374736 | PSAP | chr10 | 73576058 | - | ABCA1 | chr9 | 107567001 | - | 0.000552097 | 0.9994479 |
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Fusion Genomic Features for PSAP-ABCA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PSAP-ABCA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:73576058/chr9:107567001) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ABCA1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. {ECO:0000269|PubMed:33293368}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 18_58 | 906 | 525.0 | Domain | Saposin A-type 1 |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 194_275 | 906 | 525.0 | Domain | Saposin B-type 2 |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 311_392 | 906 | 525.0 | Domain | Saposin B-type 3 |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 405_486 | 906 | 525.0 | Domain | Saposin B-type 4 |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 488_524 | 906 | 525.0 | Domain | Saposin A-type 2 |
| Hgene | PSAP | chr10:73576058 | chr9:107567001 | ENST00000394936 | - | 14 | 14 | 59_142 | 906 | 525.0 | Domain | Saposin B-type 1 |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1912_2144 | 1488 | 2262.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1946_1953 | 1488 | 2262.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1657_1677 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1703_1723 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1735_1755 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1768_1788 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1802_1822 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1852_1872 | 1488 | 2262.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 899_1131 | 1488 | 2262.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 933_940 | 1488 | 2262.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1372_1656 | 1488 | 2262.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 43_639 | 1488 | 2262.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1041_1057 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 1351_1371 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 22_42 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 640_660 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 683_703 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 716_736 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 745_765 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 777_797 | 1488 | 2262.0 | Transmembrane | Helical | |
| Tgene | ABCA1 | chr10:73576058 | chr9:107567001 | ENST00000374736 | 30 | 50 | 827_847 | 1488 | 2262.0 | Transmembrane | Helical |
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Fusion Gene Sequence for PSAP-ABCA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >69374_69374_1_PSAP-ABCA1_PSAP_chr10_73576058_ENST00000394934_ABCA1_chr9_107567001_ENST00000374736_length(transcript)=8460nt_BP=2825nt GGGGTTAGCGCCTGCGCTCTGGACGGCTTTGGGGCAGGGCAGATTTATATCTGCGGGGGATCAGCTGACGCTCCGCATTGCAGACTGCGG AGTCAGACGGCGCTATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTTGGACTGAAAGAATGCA CCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCCGACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGC CAACAGTGAAATCCCTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAATGCCACTGAGGAGGAGA TCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCGAACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTG TCATCCTGGACATCATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCTCTCCAGAAGCACCTAG CAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCAGAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCC CTCTCCTCCTCTACCCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGACTGCATTCAGATGGTGA CTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAGGCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTG GCATGGCCGACATATGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCTTCAGCAACCCAAGGAGA TCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATGCCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCC CTGCCCTGGAACTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTGTGTGAATTCCTGGTGAAGG AGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAAATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGT CGGAAGAGTGCCAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGCCCTGAGCTGGTGTGCAGCA TGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACCGTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGA AGCTGGTGGGTTATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGC CAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCT TCGTGTGCTTGAAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGGGGCCCAAGCTACTGGTGCC AGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCATTGCAAACGCCATGTGTGGAACTAGGAGGAGGAATATTCCATCTTGGCAG AAACCACAGCATTGGTTTTTTTCTACTTGTGTGTCTGGGGGAATGAACGCACAGATCTGTTTGACTTTGTTATAAAAATAGGGCTCCCCC ACCTCCCCCATTTCTGTGTCCTTTATTGTAGCATTGCTGTCTGCAAGGGAGCCCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGCCCCT TTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTTAGCCTGCCCTTGCATGGCGCCTGCTGGAGGAGGAGAGAGCTCTGCTGG CATGAGCCACAGTTTCTTGACTGGAGGCCATCAACCCTCTTGGTTGAGGCCTTGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGC CTGGGCTTCTGAGGTGGCCTCCTGCCCTGATCAGGGACCCTCCCCGCTTTCCTGGGCCTCTCAGTTGAACAAAGCAGCAAAACAAAGGCA GTTTTATATGAAAGATTAGAAGCCTGGAATAATCAGGCTTTTTAAATGATGTAATTCCCACTGTAATAGCATAGGGATTTTGGAAGCAGC TGCTGGTGGCTTGGGACATCAGTGGGGCCAAGGGTTCTCTGTCCCTGGTTCAACTGTGATTTGGCTTTCCCGTGTCTTTCCTGGTGATGC CTTGTTTGGGGTTCTGTGGGTTTGGGTGGGAAGAGGGCCATCTGCCTGAATGTAACCTGCTAGCTCTCCGAAGGCCCTGCGGGCCTGGCT TGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTACATGTCCCTGGCTGTTGAGGCGCTGCTTCAGCCTGCAC CCCTCCCTTGTCTCATAGATGCTCCTTTTGACCTTTTCAAATAAATATGGATGGCGAGCTCCTAGGCCTCTGGCTTCCTGGTAGAGGGCG GCATGCCGAAGGGTCTGCTGGGTGTGGATTGGATGCTGGGGTGTGGGGGTTGGAAGCTGTCTGTGGCCCACTTGGGCACCCACGCTTCTG TCCACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGACATGAAGTTGCTATTAAATGGACTTCGTGATTTTTGTTTTGCACTAA AGTTTCTGTGATTTAACAATAAAATTCTGTTAGCCAGAAAACAAAACACTGCAGATATCCTTCAGGACCTGACAGGAAGAAACATTTCGG ATTATCTGGTGAAGACGTATGTGCAGATCATAGCCAAAAGCTTAAAGAACAAGATCTGGGTGAATGAGTTTAGGTATGGCGGCTTTTCCC TGGGTGTCAGTAATACTCAAGCACTTCCTCCGAGTCAAGAAGTTAATGATGCCATCAAACAAATGAAGAAACACCTAAAGCTGGCCAAGG ACAGTTCTGCAGATCGATTTCTCAACAGCTTGGGAAGATTTATGACAGGACTGGACACCAAAAATAATGTCAAGGTGTGGTTCAATAACA AGGGCTGGCATGCAATCAGCTCTTTCCTGAATGTCATCAACAATGCCATTCTCCGGGCCAACCTGCAAAAGGGAGAGAACCCTAGCCATT ATGGAATTACTGCTTTCAATCATCCCCTGAATCTCACCAAGCAGCAGCTCTCAGAGGTGGCTCTGATGACCACATCAGTGGATGTCCTTG TGTCCATCTGTGTCATCTTTGCAATGTCCTTCGTCCCAGCCAGCTTTGTCGTATTCCTGATCCAGGAGCGGGTCAGCAAAGCAAAACACC TGCAGTTCATCAGTGGAGTGAAGCCTGTCATCTACTGGCTCTCTAATTTTGTCTGGGATATGTGCAATTACGTTGTCCCTGCCACACTGG TCATTATCATCTTCATCTGCTTCCAGCAGAAGTCCTATGTGTCCTCCACCAATCTGCCTGTGCTAGCCCTTCTACTTTTGCTGTATGGGT GGTCAATCACACCTCTCATGTACCCAGCCTCCTTTGTGTTCAAGATCCCCAGCACAGCCTATGTGGTGCTCACCAGCGTGAACCTCTTCA TTGGCATTAATGGCAGCGTGGCCACCTTTGTGCTGGAGCTGTTCACCGACAATAAGCTGAATAATATCAATGATATCCTGAAGTCCGTGT TCTTGATCTTCCCACATTTTTGCCTGGGACGAGGGCTCATCGACATGGTGAAAAACCAGGCAATGGCTGATGCCCTGGAAAGGTTTGGGG AGAATCGCTTTGTGTCACCATTATCTTGGGACTTGGTGGGACGAAACCTCTTCGCCATGGCCGTGGAAGGGGTGGTGTTCTTCCTCATTA CTGTTCTGATCCAGTACAGATTCTTCATCAGGCCCAGACCTGTAAATGCAAAGCTATCTCCTCTGAATGATGAAGATGAAGATGTGAGGC GGGAAAGACAGAGAATTCTTGATGGTGGAGGCCAGAATGACATCTTAGAAATCAAGGAGTTGACGAAGATATATAGAAGGAAGCGGAAGC CTGCTGTTGACAGGATTTGCGTGGGCATTCCTCCTGGTGAGTGCTTTGGGCTCCTGGGAGTTAATGGGGCTGGAAAATCATCAACTTTCA AGATGTTAACAGGAGATACCACTGTTACCAGAGGAGATGCTTTCCTTAACAAAAATAGTATCTTATCAAACATCCATGAAGTACATCAGA ACATGGGCTACTGCCCTCAGTTTGATGCCATCACAGAGCTGTTGACTGGGAGAGAACACGTGGAGTTCTTTGCCCTTTTGAGAGGAGTCC CAGAGAAAGAAGTTGGCAAGGTTGGTGAGTGGGCGATTCGGAAACTGGGCCTCGTGAAGTATGGAGAAAAATATGCTGGTAACTATAGTG GAGGCAACAAACGCAAGCTCTCTACAGCCATGGCTTTGATCGGCGGGCCTCCTGTGGTGTTTCTGGATGAACCCACCACAGGCATGGATC CCAAAGCCCGGCGGTTCTTGTGGAATTGTGCCCTAAGTGTTGTCAAGGAGGGGAGATCAGTAGTGCTTACATCTCATAGTATGGAAGAAT GTGAAGCTCTTTGCACTAGGATGGCAATCATGGTCAATGGAAGGTTCAGGTGCCTTGGCAGTGTCCAGCATCTAAAAAATAGGTTTGGAG ATGGTTATACAATAGTTGTACGAATAGCAGGGTCCAACCCGGACCTGAAGCCTGTCCAGGATTTCTTTGGACTTGCATTTCCTGGAAGTG TTCTAAAAGAGAAACACCGGAACATGCTACAATACCAGCTTCCATCTTCATTATCTTCTCTGGCCAGGATATTCAGCATCCTCTCCCAGA GCAAAAAGCGACTCCACATAGAAGACTACTCTGTTTCTCAGACAACACTTGACCAAGTATTTGTGAACTTTGCCAAGGACCAAAGTGATG ATGACCACTTAAAAGACCTCTCATTACACAAAAACCAGACAGTAGTGGACGTTGCAGTTCTCACATCTTTTCTACAGGATGAGAAAGTGA AAGAAAGCTATGTATGAAGAATCCTGTTCATACGGGGTGGCTGAAAGTAAAGAGGAACTAGACTTTCCTTTGCACCATGTGAAGTGTTGT GGAGAAAAGAGCCAGAAGTTGATGTGGGAAGAAGTAAACTGGATACTGTACTGATACTATTCAATGCAATGCAATTCAATGCAATGAAAA CAAAATTCCATTACAGGGGCAGTGCCTTTGTAGCCTATGTCTTGTATGGCTCTCAAGTGAAAGACTTGAATTTAGTTTTTTACCTATACC TATGTGAAACTCTATTATGGAACCCAATGGACATATGGGTTTGAACTCACACTTTTTTTTTTTTTTTTGTTCCTGTGTATTCTCATTGGG GTTGCAACAATAATTCATCAAGTAATCATGGCCAGCGATTATTGATCAAAATCAAAAGGTAATGCACATCCTCATTCACTAAGCCATGCC ATGCCCAGGAGACTGGTTTCCCGGTGACACATCCATTGCTGGCAATGAGTGTGCCAGAGTTATTAGTGCCAAGTTTTTCAGAAAGTTTGA AGCACCATGGTGTGTCATGCTCACTTTTGTGAAAGCTGCTCTGCTCAGAGTCTATCAACATTGAATATCAGTTGACAGAATGGTGCCATG CGTGGCTAACATCCTGCTTTGATTCCCTCTGATAAGCTGTTCTGGTGGCAGTAACATGCAACAAAAATGTGGGTGTCTCCAGGCACGGGA AACTTGGTTCCATTGTTATATTGTCCTATGCTTCGAGCCATGGGTCTACAGGGTCATCCTTATGAGACTCTTAAATATACTTAGATCCTG GTAAGAGGCAAAGAATCAACAGCCAAACTGCTGGGGCTGCAAGCTGCTGAAGCCAGGGCATGGGATTAAAGAGATTGTGCGTTCAAACCT AGGGAAGCCTGTGCCCATTTGTCCTGACTGTCTGCTAACATGGTACACTGCATCTCAAGATGTTTATCTGACACAAGTGTATTATTTCTG GCTTTTTGAATTAATCTAGAAAATGAAAAGATGGAGTTGTATTTTGACAAAAATGTTTGTACTTTTTAATGTTATTTGGAATTTTAAGTT CTATCAGTGACTTCTGAATCCTTAGAATGGCCTCTTTGTAGAACCCTGTGGTATAGAGGAGTATGGCCACTGCCCCACTATTTTTATTTT CTTATGTAAGTTTGCATATCAGTCATGACTAGTGCCTAGAAAGCAATGTGATGGTCAGGATCTCATGACATTATATTTGAGTTTCTTTCA GATCATTTAGGATACTCTTAATCTCACTTCATCAATCAAATATTTTTTGAGTGTATGCTGTAGCTGAAAGAGTATGTACGTACGTATAAG ACTAGAGAGATATTAAGTCTCAGTACACTTCCTGTGCCATGTTATTCAGCTCACTGGTTTACAAATATAGGTTGTCTTGTGGTTGTAGGA GCCCACTGTAACAATACTGGGCAGCCTTTTTTTTTTTTTTTTTAATTGCAACAATGCAAAAGCCAAGAAAGTATAAGGGTCACAAGTCTA AACAATGAATTCTTCAACAGGGAAAACAGCTAGCTTGAAAACTTGCTGAAAAACACAACTTGTGTTTATGGCATTTAGTACCTTCAAATA ATTGGCTTTGCAGATATTGGATACCCCATTAAATCTGACAGTCTCAAATTTTTCATCTCTTCAATCACTAGTCAAGAAAAATATAAAAAC AACAAATACTTCCATATGGAGCATTTTTCAGAGTTTTCTAACCCAGTCTTATTTTTCTAGTCAGTAAACATTTGTAAAAATACTGTTTCA CTAATACTTACTGTTAACTGTCTTGAGAGAAAAGAAAAATATGAGAGAACTATTGTTTGGGGAAGTTCAAGTGATCTTTCAATATCATTA CTAACTTCTTCCACTTTTTCCAGAATTTGAATATTAACGCTAAAGGTGTAAGACTTCAGATTTCAAATTAATCTTTCTATATTTTTTAAA TTTACAGAATATTATATAACCCACTGCTGAAAAAGAAAAAAATGATTGTTTTAGAAGTTAAAGTCAATATTGATTTTAAATATAAGTAAT GAAGGCATATTTCCAATAACTAGTGATATGGCATCGTTGCATTTTACAGTATCTTCAAAAATACAGAATTTATAGAATAATTTCTCCTCA TTTAATATTTTTCAAAATCAAAGTTATGGTTTCCTCATTTTACTAAAATCGTATTCTAATTCTTCATTATAGTAAATCTATGAGCAACTC CTTACTTCGGTTCCTCTGATTTCAAGGCCATATTTTAAAAAATCAAAAGGCACTGTGAACTATTTTGAAGAAAACACAACATTTTAATAC AGATTGAAAGGACCTCTTCTGAAGCTAGAAACAATCTATAGTTATACATCTTCATTAATACTGTGTTACCTTTTAAAATAGTAATTTTTT ACATTTTCCTGTGTAAACCTAATTGTGGTAGAAATTTTTACCAACTCTATACTCAATCAAGCAAAATTTCTGTATATTCCCTGTGGAATG TACCTATGTGAGTTTCAGAAATTCTCAAAATACGTGTTCAAAAATTTCTGCTTTTGCATCTTTGGGACACCTCAGAAAACTTATTAACAA CTGTGAATATGAGAAATACAGAAGAAAATAATAAGCCCTCTATACATAAATGCCCAGCACAATTCATTGTTAAAAAACAACCAAACCTCA CACTACTGTATTTCATTATCTGTACTGAAAGCAAATGCTTTGTGACTATTAAATGTTGCACATCATTCATTCACTGTATAGTAATCATTG ACTAAAGCCATTTGTCTGTGTTTTCTTCTTGTGGTTGTATATATCAGGTAAAATATTTTCCAAAGAGCCATGTGTCATGTAATACTGAAC CACTTTGATATTGAGACATTAATTTGTACCCTTGTTATTATCTACTAGTAATAATGTAATACTGTAGAAATATTGCTCTAATTCTTTTCA AAATTGTTGCATCCCCCTTAGAATGTTTCTATTTCCATAAGGATTTAGGTATGCTATTATCCCTTCTTATACCCTAAGATGAAGCTGTTT TTGTGCTCTTTGTTCATCATTGGCCCTCATTCCAAGCACTTTACGCTGTCTGTAATGGGATCTATTTTTGCACTGGAATATCTGAGAATT GCAAAACTAGACAAAAGTTTCACAACAGATTTCTAAGTTAAATCATTTTCATTAAAAGGAAAAAAGAAAAAAAATTTTGTATGTCAATAA CTTTATATGAAGTATTAAAATGCATATTTCTATGTTGTAATATAATGAGTCACAAAATAAAGCTGTGACAGTTCTGTTGGTCTACAGAAA >69374_69374_1_PSAP-ABCA1_PSAP_chr10_73576058_ENST00000394934_ABCA1_chr9_107567001_ENST00000374736_length(amino acids)=776AA_BP=3 MLARKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLN SLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAM SFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYP ASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLS WDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVG IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVG EWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMA IMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIED -------------------------------------------------------------- >69374_69374_2_PSAP-ABCA1_PSAP_chr10_73576058_ENST00000394936_ABCA1_chr9_107567001_ENST00000374736_length(transcript)=8501nt_BP=2866nt GCTGAGTCAGGGCGCTGTTGAGCTCGGGCAGGCCCGGATGGGGCGGGGTTAGCGCCTGCGCTCTGGACGGCTTTGGGGCAGGGCAGATTT ATATCTGCGGGGGATCAGCTGACGCTCCGCATTGCAGACTGCGGAGTCAGACGGCGCTATGTACGCCCTCTTCCTCCTGGCCAGCCTCCT GGGCGCGGCTCTAGCCGGCCCGGTCCTTGGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCCGA CTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCCCTTCCCTGCGACATATGCAAAGACGTTGTCAC CGCAGCTGGTGATATGCTGAAGGACAATGCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCGAA CATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATCATTAAAGGAGAAATGAGCCGTCCTGGGGAGGT GTGCTCTGCTCTCAACCTCTGCGAGTCTCTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCAGA GCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTACCCTCAGGACGGCCCCCGCAGCAAGCCCCAGCC AAAGGATAATGGGGACGTTTGCCAGGACTGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAGGC CTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATATGCAAGAACTATATCAGCCAGTATTCTGAAAT TGCTATCCAGATGATGATGCACATGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATGCCCATGCAGAC TCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAACTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTC TGATGTTTACTGTGAGGTGTGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAAATACTCGACGC TTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGCCAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCAT CCTGCTGGAGGAGGTCAGCCCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACCGTTCACGTGAC TCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGTTATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGA GATCCTGGCTGCTCTTGAGAAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAGTACGAGCCCGT GCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTGAAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGG AACTGAGAAGTGTATATGGGGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCATTGCAAACGCCA TGTGTGGAACTAGGAGGAGGAATATTCCATCTTGGCAGAAACCACAGCATTGGTTTTTTTCTACTTGTGTGTCTGGGGGAATGAACGCAC AGATCTGTTTGACTTTGTTATAAAAATAGGGCTCCCCCACCTCCCCCATTTCTGTGTCCTTTATTGTAGCATTGCTGTCTGCAAGGGAGC CCCTAGCCCCTGGCAGACATAGCTGCTTCAGTGCCCCTTTTCTCTCTGCTAGATGGATGTTGATGCACTGGAGGTCTTTTAGCCTGCCCT TGCATGGCGCCTGCTGGAGGAGGAGAGAGCTCTGCTGGCATGAGCCACAGTTTCTTGACTGGAGGCCATCAACCCTCTTGGTTGAGGCCT TGTTCTGAGCCCTGACATGTGCTTGGGCACTGGTGGGCCTGGGCTTCTGAGGTGGCCTCCTGCCCTGATCAGGGACCCTCCCCGCTTTCC TGGGCCTCTCAGTTGAACAAAGCAGCAAAACAAAGGCAGTTTTATATGAAAGATTAGAAGCCTGGAATAATCAGGCTTTTTAAATGATGT AATTCCCACTGTAATAGCATAGGGATTTTGGAAGCAGCTGCTGGTGGCTTGGGACATCAGTGGGGCCAAGGGTTCTCTGTCCCTGGTTCA ACTGTGATTTGGCTTTCCCGTGTCTTTCCTGGTGATGCCTTGTTTGGGGTTCTGTGGGTTTGGGTGGGAAGAGGGCCATCTGCCTGAATG TAACCTGCTAGCTCTCCGAAGGCCCTGCGGGCCTGGCTTGTGTGAGCGTGTGGACAGTGGTGGCCGCGCTGTGCCTGCTCGTGTTGCCTA CATGTCCCTGGCTGTTGAGGCGCTGCTTCAGCCTGCACCCCTCCCTTGTCTCATAGATGCTCCTTTTGACCTTTTCAAATAAATATGGAT GGCGAGCTCCTAGGCCTCTGGCTTCCTGGTAGAGGGCGGCATGCCGAAGGGTCTGCTGGGTGTGGATTGGATGCTGGGGTGTGGGGGTTG GAAGCTGTCTGTGGCCCACTTGGGCACCCACGCTTCTGTCCACTTCTGGTTGCCAGGAGACAGCAAGCAAAGCCAGCAGGACATGAAGTT GCTATTAAATGGACTTCGTGATTTTTGTTTTGCACTAAAGTTTCTGTGATTTAACAATAAAATTCTGTTAGCCAGAAGAAAACAAAACAC TGCAGATATCCTTCAGGACCTGACAGGAAGAAACATTTCGGATTATCTGGTGAAGACGTATGTGCAGATCATAGCCAAAAGCTTAAAGAA CAAGATCTGGGTGAATGAGTTTAGGTATGGCGGCTTTTCCCTGGGTGTCAGTAATACTCAAGCACTTCCTCCGAGTCAAGAAGTTAATGA TGCCATCAAACAAATGAAGAAACACCTAAAGCTGGCCAAGGACAGTTCTGCAGATCGATTTCTCAACAGCTTGGGAAGATTTATGACAGG ACTGGACACCAAAAATAATGTCAAGGTGTGGTTCAATAACAAGGGCTGGCATGCAATCAGCTCTTTCCTGAATGTCATCAACAATGCCAT TCTCCGGGCCAACCTGCAAAAGGGAGAGAACCCTAGCCATTATGGAATTACTGCTTTCAATCATCCCCTGAATCTCACCAAGCAGCAGCT CTCAGAGGTGGCTCTGATGACCACATCAGTGGATGTCCTTGTGTCCATCTGTGTCATCTTTGCAATGTCCTTCGTCCCAGCCAGCTTTGT CGTATTCCTGATCCAGGAGCGGGTCAGCAAAGCAAAACACCTGCAGTTCATCAGTGGAGTGAAGCCTGTCATCTACTGGCTCTCTAATTT TGTCTGGGATATGTGCAATTACGTTGTCCCTGCCACACTGGTCATTATCATCTTCATCTGCTTCCAGCAGAAGTCCTATGTGTCCTCCAC CAATCTGCCTGTGCTAGCCCTTCTACTTTTGCTGTATGGGTGGTCAATCACACCTCTCATGTACCCAGCCTCCTTTGTGTTCAAGATCCC CAGCACAGCCTATGTGGTGCTCACCAGCGTGAACCTCTTCATTGGCATTAATGGCAGCGTGGCCACCTTTGTGCTGGAGCTGTTCACCGA CAATAAGCTGAATAATATCAATGATATCCTGAAGTCCGTGTTCTTGATCTTCCCACATTTTTGCCTGGGACGAGGGCTCATCGACATGGT GAAAAACCAGGCAATGGCTGATGCCCTGGAAAGGTTTGGGGAGAATCGCTTTGTGTCACCATTATCTTGGGACTTGGTGGGACGAAACCT CTTCGCCATGGCCGTGGAAGGGGTGGTGTTCTTCCTCATTACTGTTCTGATCCAGTACAGATTCTTCATCAGGCCCAGACCTGTAAATGC AAAGCTATCTCCTCTGAATGATGAAGATGAAGATGTGAGGCGGGAAAGACAGAGAATTCTTGATGGTGGAGGCCAGAATGACATCTTAGA AATCAAGGAGTTGACGAAGATATATAGAAGGAAGCGGAAGCCTGCTGTTGACAGGATTTGCGTGGGCATTCCTCCTGGTGAGTGCTTTGG GCTCCTGGGAGTTAATGGGGCTGGAAAATCATCAACTTTCAAGATGTTAACAGGAGATACCACTGTTACCAGAGGAGATGCTTTCCTTAA CAAAAATAGTATCTTATCAAACATCCATGAAGTACATCAGAACATGGGCTACTGCCCTCAGTTTGATGCCATCACAGAGCTGTTGACTGG GAGAGAACACGTGGAGTTCTTTGCCCTTTTGAGAGGAGTCCCAGAGAAAGAAGTTGGCAAGGTTGGTGAGTGGGCGATTCGGAAACTGGG CCTCGTGAAGTATGGAGAAAAATATGCTGGTAACTATAGTGGAGGCAACAAACGCAAGCTCTCTACAGCCATGGCTTTGATCGGCGGGCC TCCTGTGGTGTTTCTGGATGAACCCACCACAGGCATGGATCCCAAAGCCCGGCGGTTCTTGTGGAATTGTGCCCTAAGTGTTGTCAAGGA GGGGAGATCAGTAGTGCTTACATCTCATAGTATGGAAGAATGTGAAGCTCTTTGCACTAGGATGGCAATCATGGTCAATGGAAGGTTCAG GTGCCTTGGCAGTGTCCAGCATCTAAAAAATAGGTTTGGAGATGGTTATACAATAGTTGTACGAATAGCAGGGTCCAACCCGGACCTGAA GCCTGTCCAGGATTTCTTTGGACTTGCATTTCCTGGAAGTGTTCTAAAAGAGAAACACCGGAACATGCTACAATACCAGCTTCCATCTTC ATTATCTTCTCTGGCCAGGATATTCAGCATCCTCTCCCAGAGCAAAAAGCGACTCCACATAGAAGACTACTCTGTTTCTCAGACAACACT TGACCAAGTATTTGTGAACTTTGCCAAGGACCAAAGTGATGATGACCACTTAAAAGACCTCTCATTACACAAAAACCAGACAGTAGTGGA CGTTGCAGTTCTCACATCTTTTCTACAGGATGAGAAAGTGAAAGAAAGCTATGTATGAAGAATCCTGTTCATACGGGGTGGCTGAAAGTA AAGAGGAACTAGACTTTCCTTTGCACCATGTGAAGTGTTGTGGAGAAAAGAGCCAGAAGTTGATGTGGGAAGAAGTAAACTGGATACTGT ACTGATACTATTCAATGCAATGCAATTCAATGCAATGAAAACAAAATTCCATTACAGGGGCAGTGCCTTTGTAGCCTATGTCTTGTATGG CTCTCAAGTGAAAGACTTGAATTTAGTTTTTTACCTATACCTATGTGAAACTCTATTATGGAACCCAATGGACATATGGGTTTGAACTCA CACTTTTTTTTTTTTTTTTGTTCCTGTGTATTCTCATTGGGGTTGCAACAATAATTCATCAAGTAATCATGGCCAGCGATTATTGATCAA AATCAAAAGGTAATGCACATCCTCATTCACTAAGCCATGCCATGCCCAGGAGACTGGTTTCCCGGTGACACATCCATTGCTGGCAATGAG TGTGCCAGAGTTATTAGTGCCAAGTTTTTCAGAAAGTTTGAAGCACCATGGTGTGTCATGCTCACTTTTGTGAAAGCTGCTCTGCTCAGA GTCTATCAACATTGAATATCAGTTGACAGAATGGTGCCATGCGTGGCTAACATCCTGCTTTGATTCCCTCTGATAAGCTGTTCTGGTGGC AGTAACATGCAACAAAAATGTGGGTGTCTCCAGGCACGGGAAACTTGGTTCCATTGTTATATTGTCCTATGCTTCGAGCCATGGGTCTAC AGGGTCATCCTTATGAGACTCTTAAATATACTTAGATCCTGGTAAGAGGCAAAGAATCAACAGCCAAACTGCTGGGGCTGCAAGCTGCTG AAGCCAGGGCATGGGATTAAAGAGATTGTGCGTTCAAACCTAGGGAAGCCTGTGCCCATTTGTCCTGACTGTCTGCTAACATGGTACACT GCATCTCAAGATGTTTATCTGACACAAGTGTATTATTTCTGGCTTTTTGAATTAATCTAGAAAATGAAAAGATGGAGTTGTATTTTGACA AAAATGTTTGTACTTTTTAATGTTATTTGGAATTTTAAGTTCTATCAGTGACTTCTGAATCCTTAGAATGGCCTCTTTGTAGAACCCTGT GGTATAGAGGAGTATGGCCACTGCCCCACTATTTTTATTTTCTTATGTAAGTTTGCATATCAGTCATGACTAGTGCCTAGAAAGCAATGT GATGGTCAGGATCTCATGACATTATATTTGAGTTTCTTTCAGATCATTTAGGATACTCTTAATCTCACTTCATCAATCAAATATTTTTTG AGTGTATGCTGTAGCTGAAAGAGTATGTACGTACGTATAAGACTAGAGAGATATTAAGTCTCAGTACACTTCCTGTGCCATGTTATTCAG CTCACTGGTTTACAAATATAGGTTGTCTTGTGGTTGTAGGAGCCCACTGTAACAATACTGGGCAGCCTTTTTTTTTTTTTTTTTAATTGC AACAATGCAAAAGCCAAGAAAGTATAAGGGTCACAAGTCTAAACAATGAATTCTTCAACAGGGAAAACAGCTAGCTTGAAAACTTGCTGA AAAACACAACTTGTGTTTATGGCATTTAGTACCTTCAAATAATTGGCTTTGCAGATATTGGATACCCCATTAAATCTGACAGTCTCAAAT TTTTCATCTCTTCAATCACTAGTCAAGAAAAATATAAAAACAACAAATACTTCCATATGGAGCATTTTTCAGAGTTTTCTAACCCAGTCT TATTTTTCTAGTCAGTAAACATTTGTAAAAATACTGTTTCACTAATACTTACTGTTAACTGTCTTGAGAGAAAAGAAAAATATGAGAGAA CTATTGTTTGGGGAAGTTCAAGTGATCTTTCAATATCATTACTAACTTCTTCCACTTTTTCCAGAATTTGAATATTAACGCTAAAGGTGT AAGACTTCAGATTTCAAATTAATCTTTCTATATTTTTTAAATTTACAGAATATTATATAACCCACTGCTGAAAAAGAAAAAAATGATTGT TTTAGAAGTTAAAGTCAATATTGATTTTAAATATAAGTAATGAAGGCATATTTCCAATAACTAGTGATATGGCATCGTTGCATTTTACAG TATCTTCAAAAATACAGAATTTATAGAATAATTTCTCCTCATTTAATATTTTTCAAAATCAAAGTTATGGTTTCCTCATTTTACTAAAAT CGTATTCTAATTCTTCATTATAGTAAATCTATGAGCAACTCCTTACTTCGGTTCCTCTGATTTCAAGGCCATATTTTAAAAAATCAAAAG GCACTGTGAACTATTTTGAAGAAAACACAACATTTTAATACAGATTGAAAGGACCTCTTCTGAAGCTAGAAACAATCTATAGTTATACAT CTTCATTAATACTGTGTTACCTTTTAAAATAGTAATTTTTTACATTTTCCTGTGTAAACCTAATTGTGGTAGAAATTTTTACCAACTCTA TACTCAATCAAGCAAAATTTCTGTATATTCCCTGTGGAATGTACCTATGTGAGTTTCAGAAATTCTCAAAATACGTGTTCAAAAATTTCT GCTTTTGCATCTTTGGGACACCTCAGAAAACTTATTAACAACTGTGAATATGAGAAATACAGAAGAAAATAATAAGCCCTCTATACATAA ATGCCCAGCACAATTCATTGTTAAAAAACAACCAAACCTCACACTACTGTATTTCATTATCTGTACTGAAAGCAAATGCTTTGTGACTAT TAAATGTTGCACATCATTCATTCACTGTATAGTAATCATTGACTAAAGCCATTTGTCTGTGTTTTCTTCTTGTGGTTGTATATATCAGGT AAAATATTTTCCAAAGAGCCATGTGTCATGTAATACTGAACCACTTTGATATTGAGACATTAATTTGTACCCTTGTTATTATCTACTAGT AATAATGTAATACTGTAGAAATATTGCTCTAATTCTTTTCAAAATTGTTGCATCCCCCTTAGAATGTTTCTATTTCCATAAGGATTTAGG TATGCTATTATCCCTTCTTATACCCTAAGATGAAGCTGTTTTTGTGCTCTTTGTTCATCATTGGCCCTCATTCCAAGCACTTTACGCTGT CTGTAATGGGATCTATTTTTGCACTGGAATATCTGAGAATTGCAAAACTAGACAAAAGTTTCACAACAGATTTCTAAGTTAAATCATTTT CATTAAAAGGAAAAAAGAAAAAAAATTTTGTATGTCAATAACTTTATATGAAGTATTAAAATGCATATTTCTATGTTGTAATATAATGAG >69374_69374_2_PSAP-ABCA1_PSAP_chr10_73576058_ENST00000394936_ABCA1_chr9_107567001_ENST00000374736_length(amino acids)=777AA_BP=4 MLARRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFL NSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFA MSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMY PASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL SWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICV GIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKV GEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRM AIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PSAP-ABCA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PSAP-ABCA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PSAP-ABCA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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