FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ASAP1-EFR3A (FusionGDB2 ID:6954)

Fusion Gene Summary for ASAP1-EFR3A

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP1-EFR3A
Fusion gene ID: 6954
HgeneTgene
Gene symbol

ASAP1

EFR3A

Gene ID

50807

23167

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 1EFR3 homolog A
SynonymsAMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P-
Cytomap

8q24.21-q24.22

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosylprotein EFR3 homolog A
Modification date2020032720200313
UniProtAcc

Q9ULH1

Q14156

Ensembl transtripts involved in fusion geneENST00000357668, ENST00000518721, 
ENST00000520625, 		ENST00000519656, 
ENST00000521940, ENST00000254624, 
ENST00000334503, 
Fusion gene scores* DoF score25 X 17 X 13=55259 X 9 X 7=567
# samples 2810
** MAII scorelog2(28/5525*10)=-4.30247573222119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/567*10)=-2.5033487351675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAP1 [Title/Abstract] AND EFR3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFR3A(133008744)-ASAP1(131249240), # samples:2
ASAP1(131164981)-EFR3A(132952745), # samples:1
Anticipated loss of major functional domain due to fusion event.ASAP1-EFR3A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASAP1-EFR3A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EFR3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-4022ASAP1chr8

131164981

-EFR3Achr8

132952745

+


Top

Fusion Gene ORF analysis for ASAP1-EFR3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000357668ENST00000519656ASAP1chr8

131164981

-EFR3Achr8

132952745

+
5CDS-5UTRENST00000518721ENST00000519656ASAP1chr8

131164981

-EFR3Achr8

132952745

+
5CDS-intronENST00000357668ENST00000521940ASAP1chr8

131164981

-EFR3Achr8

132952745

+
5CDS-intronENST00000518721ENST00000521940ASAP1chr8

131164981

-EFR3Achr8

132952745

+
Frame-shiftENST00000357668ENST00000254624ASAP1chr8

131164981

-EFR3Achr8

132952745

+
Frame-shiftENST00000357668ENST00000334503ASAP1chr8

131164981

-EFR3Achr8

132952745

+
In-frameENST00000518721ENST00000254624ASAP1chr8

131164981

-EFR3Achr8

132952745

+
In-frameENST00000518721ENST00000334503ASAP1chr8

131164981

-EFR3Achr8

132952745

+
intron-3CDSENST00000520625ENST00000254624ASAP1chr8

131164981

-EFR3Achr8

132952745

+
intron-3CDSENST00000520625ENST00000334503ASAP1chr8

131164981

-EFR3Achr8

132952745

+
intron-5UTRENST00000520625ENST00000519656ASAP1chr8

131164981

-EFR3Achr8

132952745

+
intron-intronENST00000520625ENST00000521940ASAP1chr8

131164981

-EFR3Achr8

132952745

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000518721ASAP1chr8131164981-ENST00000254624EFR3Achr8132952745+6511130812503763837
ENST00000518721ASAP1chr8131164981-ENST00000334503EFR3Achr8132952745+6074130812503763837

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000518721ENST00000254624ASAP1chr8131164981-EFR3Achr8132952745+0.0002851050.9997149
ENST00000518721ENST00000334503ASAP1chr8131164981-EFR3Achr8132952745+0.000325080.9996749

Top

Fusion Genomic Features for ASAP1-EFR3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASAP1chr8131164981-EFR3Achr8132952745+3.14E-050.99996865
ASAP1chr8131164981-EFR3Achr8132952745+3.14E-050.99996865

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ASAP1-EFR3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:133008744/chr8:131249240)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAP1

Q9ULH1

EFR3A

Q14156

FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229783_9933601130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330783_9933601130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-12291067_11293601130.0DomainSH3
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229324_4163601130.0DomainPH
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229439_5603601130.0DomainArf-GAP
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-13301067_11293601130.0DomainSH3
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330324_4163601130.0DomainPH
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330439_5603601130.0DomainArf-GAP
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229600_6323601130.0RepeatNote=ANK 1
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229636_6653601130.0RepeatNote=ANK 2
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330600_6323601130.0RepeatNote=ANK 1
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330636_6653601130.0RepeatNote=ANK 2
HgeneASAP1chr8:131164981chr8:132952745ENST00000357668-1229454_4773601130.0Zinc fingerC4-type
HgeneASAP1chr8:131164981chr8:132952745ENST00000518721-1330454_4773601130.0Zinc fingerC4-type


Top

Fusion Gene Sequence for ASAP1-EFR3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6954_6954_1_ASAP1-EFR3A_ASAP1_chr8_131164981_ENST00000518721_EFR3A_chr8_132952745_ENST00000254624_length(transcript)=6511nt_BP=1308nt
CCCTTCCTGCGCCGCGCTCGGCTCCCGCGCCTCGCCTGGCCTGGCCGCTGCCGCGGGCGAGCACTGTGCGCTGGGCAGCCCCGGGCCCGC
GCCTCCCGCCCAGCCGGCGCTTCCCGGTCGCAGTTCGCTTTCCCACCCGAGAGCCGCGAGCGCCCGGCCGAACCCGCGATGGAATAATGC
CCAGCGGCCCGCCAGGTCCCGGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGA
GATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCC
AGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTG
AAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGT
AATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAAT
CTGCTCCAGGGTTTGAGCCACAATGTGATCTTCACCTTGGATTCTTTGTTAAAAGGAGACCTAAAGGGAGTCAAAGGAGATCTCAAGAAG
CCATTTGACAAAGCCTGGAAAGATTATGAGACAAAGTTTACAAAAATTGAGAAAGAGAAAAGAGAGCACGCAAAACAACATGGGATGATC
CGCACAGAGATAACAGGAGCTGAGATTGCGGAAGAAATGGAGAAGGAAAGGCGCCTCTTTCAGCTCCAAATGTGTGAATATCTCATTAAA
GTTAATGAAATCAAGACCAAAAAGGGTGTGGATCTGCTGCAGAATCTTATAAAGTATTACCATGCACAGTGCAATTTCTTTCAAGATGGC
TTGAAAACAGCTGATAAGTTGAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAA
CAGCTAACTGCACTCCGAGACTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATG
CATCAGCTCCAGGGCAATAAGGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGG
AGGAAGTGTTCAGTCAAGAATGGGATTCTGACCATCTCACATGCCACAGAGTATGCTGCTGCTGTTCCGCTTTGCGTCCTCGCTACAAAC
GCCTGGTGGACAACATATTCCCTGAAGATCCAAAAGATGGCCTTGTGAAAACTGATATGGAGAAATTGACATTTTATGCAGTATCTGCTC
CAGAGAAACTGGATCGAATTGGTTCTTACCTGGCAGAAAGGTTGAGCAGGGATGTTGTCAGACATCGTTCTGGGTATGTTTTGATTGCTA
TGGAGGCACTGGACCAACTTCTCATGGCTTGCCATTCTCAAAGCATTAAGCCATTTGTAGAAAGCTTTCTTCATATGGTGGCAAAGCTGC
TGGAATCGGGGGAACCAAAGCTTCAAGTTCTTGGAACAAATTCTTTTGTCAAATTTGCAAATATTGAAGAAGACACACCATCCTATCACA
GACGTTATGACTTTTTTGTGTCTCGATTCAGTGCCATGTGCCATTCCTGTCATAGTGATCCAGAAATACGAACAGAGATACGAATTGCTG
GAATTAGAGGTATTCAAGGTGTGGTTCGCAAAACAGTCAACGATGAACTTCGGGCCACCATTTGGGAACCTCAGCATATGGATAAGATTG
TTCCATCCCTCCTGTTTAACATGCAAAAGATAGAAGAAGTTGACAGTCGCATAGGCCCTCCTTCTTCTCCTTCTGCAACTGACAAAGAAG
AGAATCCTGCTGTGCTGGCTGAAAACTGTTTCAGAGAACTGCTGGGTCGAGCAACTTTTGGGAATATGAATAATGCTGTTAGACCAGTTT
TTGCGCATTTAGATCATCACAAACTGTGGGATCCCAATGAATTTGCAGTTCACTGCTTTAAAATTATAATGTATTCCATTCAGGCTCAGT
ATTCTCACCATGTGATCCAGGAGATTCTAGGACACCTTGATGCTCGTAAAAAAGATGCTCCCCGGGTTCGAGCAGGTATTATTCAGGTTC
TGTTAGAGGCTGTTGCCATTGCTGCTAAAGGTTCCATAGGTCCGACAGTGCTGGAAGTCTTCAATACCCTTTTGAAACATCTGCGTCTCA
GCGTTGAATTCGAAGCAAATGATTTACAGGGGGGATCTGTAGGCAGTGTCAACTTAAATACAAGTTCCAAAGACAATGATGAGAAGATTG
TGCAGAATGCTATCATCCAAACAATAGGATTTTTTGGAAGTAACCTACCAGATTATCAGAGGTCAGAAATCATGATGTTCATTATGGGGA
AAGTACCTGTCTTTGGAACATCTACCCATACTTTGGATATCAGTCAACTAGGGGATTTGGGAACCAGGAGAATTCAGATAATGTTGCTGA
GATCTTTGCTTATGGTGACCTCTGGATATAAAGCGAAGACGATTGTTACTGCACTGCCAGGGTCTTTCCTGGATCCTTTGTTATCACCAT
CTCTCATGGAGGACTACGAACTGAGACAGTTGGTCTTGGAAGTAATGCATAATCTCATGGATCGTCATGACAATAGGGCAAAGCTTCGAG
GGATCAGAATAATACCGGATGTAGCTGACCTAAAGATAAAAAGAGAAAAAATTTGCAGACAAGACACAAGTTTCATGAAAAAGAATGGGC
AACAGCTGTATCGGCACATATATTTGGGTTGTAAAGAGGAAGACAACGTTCAGAAAAACTATGAACTACTTTATACTTCTCTTGCTCTTA
TAACTATTGAACTGGCTAATGAAGAAGTAGTTATTGATCTCATTCGACTGGCCATTGCTTTACAGGACAGTGCAATTATCAATGAGGATA
ATTTGCCAATGTTCCATCGTTGTGGAATCATGGCACTGGTTGCAGCATACCTCAACTTTGTAAGTCAGATGATAGCTGTCCCTGCATTTT
GCCAGCATGTTAGCAAGGTTATTGAAATTCGAACTATGGAAGCCCCTTATTTTCTACCAGAGCATATCTTCAGAGATAAGTGCATGCTTC
CAAAATCTTTAGAGAAGCATGAAAAAGATTTGTACTTTCTGACCAACAAGATTGCAGAGTCGCTAGGTGGAAGTGGATATAGTGTTGAGA
GATTGTCAGTTCCGTATGTACCACAAGTAACAGATGAAGATCGACTTTCTAGAAGAAAAAGCATTGTGGACACCGTATCCATTCAGGTGG
ATATTTTATCCAACAATGTTCCTTCTGATGATGTGGTTAGTAACACTGAAGAAATCACTTTTGAAGCATTGAAGAAAGCAATTGATACCA
GTGGAATGGAAGAACAGGAAAAGGAAAAGAGGCGTCTTGTGATAGAGAAATTTCAGAAAGCACCTTTTGAAGAAATAGCAGCACAGTGTG
AATCCAAAGCAAATTTGCTTCATGATAGACTTGCCCAAATATTGGAACTCACCATACGTCCTCCTCCCAGTCCATCAGGAACACTGACCA
TTACTTCTGGGCATGCCCAATACCAATCTGTCCCAGTCTATGAGATGAAGTTTCCAGATCTGTGTGTGTACTGATCGGCGCATGAAGACC
TCAGGATATGATTTGTAAAGCCTAAAAATTAAGGCCAAGCTGAGCTTTCAGGGTTTACTTAATGTGTATTAACATACTTCTTGAAAATAA
TGATGGAACATATCTTTAACCAAATGTTTGGCATACCATATTAGAAGTTTTGGAGCTATATATAATTTCGAGTACTTTCAAAGATAGATT
TATGCCATGTTAATTTGCTTTGAGGTTCCTGTTGCCTTTTTAAGTTGAACATGTTTTGGTTTCACTTTATTCCACTGTTAAGTAGTATGT
TTTAAACTTTTCACAAATGTAATGTTTTTTAAAAAGTAAGCCTTCAGAGGATTGAAACTGTATAAATTGTTTATCTCTTAAACATCTACA
CAGCCGCTTAGATGTAGAATTTTTGTTGTTGTTTTCTGCAAAGGCAGATACATTTAAATATATTCCTAGTCCTGGGACTGCAAAACTGTT
CGGTGGCTTTTTGTCCCCATGCTTTAGATAAGCTGGGATAGGCACCTTGCTATTCAGTTACTATAATAATATGTGATAGGCATTCCTCAT
CTTCTTCACAATAATAGGACATCTGTTGAATAGCATTCCTCGAATATAACCCTAAAAACGCCATACTTTAAATTGTCTGGTTCTTGTAAT
ATTGTGTTTCCTGCCAAGAGTTTGACCATTCTGCTTGAGAAGTGTAGAGCTTACTCTTGGAGTACCAAACTGTGCAATATTTTTACATCA
TAAGATGTATTAGTTTACAGGCTGTGCTTTGAAATTATAGTAGTATTTTGCTGTGGCTCCATTAATTAAATGAGATATATATTTAGTGCA
GAAAAAAGACATTTAAAACAGCTATTAGTTCACCTGTGAAGAGTCTGTACATTTTGATTTCTATTAAGAGCACATTTATTTACATTTGTA
TATTATTTTAAATCCTCATAGTCAAAAAATTCTCCAGATGGACTTTTAATTTGTAAGATTTGAACTGTGACTTGTATACATCTGTTTAGA
ATCAATTATATTTGAAAAGCTGCCTGTGTTTTAACAGTCAAGTGTGCTAAAGTTTGTCAATTTAAGCTGCTTTTGATTTCAGCTACCAAG
ATCACAGGTGCACTCTACACATAACACTGACAGACCCATAACATTACATACATCTTAGTGAATTCTATCACATGGTAAAATGAACAGCTT
TCTTTGTAACTCATAAAATTCTCTTAGGACATTTTTATAAAGTCACCTGTTTATAGTTCTATCTTTTCAGATTCCATTTCTTTTTACATA
AAACAGCATACATATCAAAAACTGTAGCCTAGAATACAGTTTAATTTTTGGCTTTTGTTTTTGTTTAAAAAATTGCAGTGAAGAATGGGA
TGTTTGTGTTTATGGCTATTTGGGCACCTTTAGTAGAAACAGACAAAAGTAAGGAAACGATAATAGGACAAGCATACTTGAAAATTTCTG
AATACTTAAACAAAAGCGCAACATCTTGAAAACCAGTCTAGTCATTGAAACCTATGAAATGACACTGAAAGATCCTGGGCTGCTTCTTAA
ATAAGTAGATCAGCAAGACTTGTTTCAGAGTGACAGTGGAGTCGTTACCGCTGGAGGACTAAAGGGCCCTGTGGCAGCTGTCACTGGAAC
TTTGCCTCTTGATCAGGAAAAATGCTTCACCAGTCCGTAAAGCCAAGTTGTATTTTTTTAATTGCCCTTTTTTCCTTCTGTATTTTTAAA
GAAGGATGTTAATTTTTGACTATATATTTTAAAAAAATCTAAGCAGGGGGACATGCAAAAACAATCATCATCCACTTGGATGTCATTTTA
TAGATTAACACTGTGTGCTTTTGTATGGAAAAAATATATATAATTTAATAGTATAAAAAATAAAATATATATTCATTTGCACTTACGTGA
AACACAAACTTTGCTCTACAAAATTTCGTGTTTCTTAGTGATTTTAAAATGCATGTATTGCATGTAAAGGAAAACCATTACAATTAATGT
TTATCACACCTTTATCTTGGTCTTTGTTGATTTGGGTTTTGTTGGGGTTTTTGTTACTGTTTTTAAATTACAGTAGGCTTCTATATATCC
TGGATTTCTGAACTGGTCTTGTTGACAAGGATTCCCAAGAAATGGATCTTTTCACTGGCTGACTCTCCCATATCTGCAAGAGATTCTGCA
GGAACTGGGTGTGCACACGGTGTTGTAGCCAGTTCAGGTACTGAATATTTAGGATTTGGTGAAGTTCACTGTATTGCTATATTTTTGTAG
ATAAATAAAACTCAATAAATTGTTAATCATTCTCTTTTTGCTGTATAGAATTGCTTATATCACTCTTTCTTTCATGACATTGGTTAACAT
TTAAATGTTCCTCCTGTACTTGTGTTGTCTGTGACCGCTTATAGAGTTTTATTGTTATTGGTGTTTACCTGAATACCTATGCGTACACAC
ACACATATTTCCTTAATACTTCTGAACTCATTATCTTTTAGAATAATAATACTACTACACTTTACCAGCAATTAACTTCTCCCTACCCAA
AATGTTTTTCTTCCTGTCTGAAAATGGAACTAATTTGTCTTATTCGTGCTTATATCTGTATTAAATGCAATAAAGTTAGTTTTTGAAATG
TAAAAATTCACTGTGCAATTCATATGTCAGCAATAAAACATAGATTATTTGTATATAAGTTCATTTTTATAGCTATTGTTACATTTAATT

>6954_6954_1_ASAP1-EFR3A_ASAP1_chr8_131164981_ENST00000518721_EFR3A_chr8_132952745_ENST00000254624_length(amino acids)=837AA_BP=20
MAEEEVFSQEWDSDHLTCHRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKTDMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRSGYV
LIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEI
RIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRIGPPSSPSATDKEENPAVLAENCFRELLGRATFGNMNNAV
RPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARKKDAPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKH
LRLSVEFEANDLQGGSVGSVNLNTSSKDNDEKIVQNAIIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQI
MLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMK
KNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAV
PAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHEKDLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVS
IQVDILSNNVPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSG

--------------------------------------------------------------
>6954_6954_2_ASAP1-EFR3A_ASAP1_chr8_131164981_ENST00000518721_EFR3A_chr8_132952745_ENST00000334503_length(transcript)=6074nt_BP=1308nt
CCCTTCCTGCGCCGCGCTCGGCTCCCGCGCCTCGCCTGGCCTGGCCGCTGCCGCGGGCGAGCACTGTGCGCTGGGCAGCCCCGGGCCCGC
GCCTCCCGCCCAGCCGGCGCTTCCCGGTCGCAGTTCGCTTTCCCACCCGAGAGCCGCGAGCGCCCGGCCGAACCCGCGATGGAATAATGC
CCAGCGGCCCGCCAGGTCCCGGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGA
GATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCC
AGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTG
AAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGT
AATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAAT
CTGCTCCAGGGTTTGAGCCACAATGTGATCTTCACCTTGGATTCTTTGTTAAAAGGAGACCTAAAGGGAGTCAAAGGAGATCTCAAGAAG
CCATTTGACAAAGCCTGGAAAGATTATGAGACAAAGTTTACAAAAATTGAGAAAGAGAAAAGAGAGCACGCAAAACAACATGGGATGATC
CGCACAGAGATAACAGGAGCTGAGATTGCGGAAGAAATGGAGAAGGAAAGGCGCCTCTTTCAGCTCCAAATGTGTGAATATCTCATTAAA
GTTAATGAAATCAAGACCAAAAAGGGTGTGGATCTGCTGCAGAATCTTATAAAGTATTACCATGCACAGTGCAATTTCTTTCAAGATGGC
TTGAAAACAGCTGATAAGTTGAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAA
CAGCTAACTGCACTCCGAGACTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATG
CATCAGCTCCAGGGCAATAAGGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGG
AGGAAGTGTTCAGTCAAGAATGGGATTCTGACCATCTCACATGCCACAGAGTATGCTGCTGCTGTTCCGCTTTGCGTCCTCGCTACAAAC
GCCTGGTGGACAACATATTCCCTGAAGATCCAAAAGATGGCCTTGTGAAAACTGATATGGAGAAATTGACATTTTATGCAGTATCTGCTC
CAGAGAAACTGGATCGAATTGGTTCTTACCTGGCAGAAAGGTTGAGCAGGGATGTTGTCAGACATCGTTCTGGGTATGTTTTGATTGCTA
TGGAGGCACTGGACCAACTTCTCATGGCTTGCCATTCTCAAAGCATTAAGCCATTTGTAGAAAGCTTTCTTCATATGGTGGCAAAGCTGC
TGGAATCGGGGGAACCAAAGCTTCAAGTTCTTGGAACAAATTCTTTTGTCAAATTTGCAAATATTGAAGAAGACACACCATCCTATCACA
GACGTTATGACTTTTTTGTGTCTCGATTCAGTGCCATGTGCCATTCCTGTCATAGTGATCCAGAAATACGAACAGAGATACGAATTGCTG
GAATTAGAGGTATTCAAGGTGTGGTTCGCAAAACAGTCAACGATGAACTTCGGGCCACCATTTGGGAACCTCAGCATATGGATAAGATTG
TTCCATCCCTCCTGTTTAACATGCAAAAGATAGAAGAAGTTGACAGTCGCATAGGCCCTCCTTCTTCTCCTTCTGCAACTGACAAAGAAG
AGAATCCTGCTGTGCTGGCTGAAAACTGTTTCAGAGAACTGCTGGGTCGAGCAACTTTTGGGAATATGAATAATGCTGTTAGACCAGTTT
TTGCGCATTTAGATCATCACAAACTGTGGGATCCCAATGAATTTGCAGTTCACTGCTTTAAAATTATAATGTATTCCATTCAGGCTCAGT
ATTCTCACCATGTGATCCAGGAGATTCTAGGACACCTTGATGCTCGTAAAAAAGATGCTCCCCGGGTTCGAGCAGGTATTATTCAGGTTC
TGTTAGAGGCTGTTGCCATTGCTGCTAAAGGTTCCATAGGTCCGACAGTGCTGGAAGTCTTCAATACCCTTTTGAAACATCTGCGTCTCA
GCGTTGAATTCGAAGCAAATGATTTACAGGGGGGATCTGTAGGCAGTGTCAACTTAAATACAAGTTCCAAAGACAATGATGAGAAGATTG
TGCAGAATGCTATCATCCAAACAATAGGATTTTTTGGAAGTAACCTACCAGATTATCAGAGGTCAGAAATCATGATGTTCATTATGGGGA
AAGTACCTGTCTTTGGAACATCTACCCATACTTTGGATATCAGTCAACTAGGGGATTTGGGAACCAGGAGAATTCAGATAATGTTGCTGA
GATCTTTGCTTATGGTGACCTCTGGATATAAAGCGAAGACGATTGTTACTGCACTGCCAGGGTCTTTCCTGGATCCTTTGTTATCACCAT
CTCTCATGGAGGACTACGAACTGAGACAGTTGGTCTTGGAAGTAATGCATAATCTCATGGATCGTCATGACAATAGGGCAAAGCTTCGAG
GGATCAGAATAATACCGGATGTAGCTGACCTAAAGATAAAAAGAGAAAAAATTTGCAGACAAGACACAAGTTTCATGAAAAAGAATGGGC
AACAGCTGTATCGGCACATATATTTGGGTTGTAAAGAGGAAGACAACGTTCAGAAAAACTATGAACTACTTTATACTTCTCTTGCTCTTA
TAACTATTGAACTGGCTAATGAAGAAGTAGTTATTGATCTCATTCGACTGGCCATTGCTTTACAGGACAGTGCAATTATCAATGAGGATA
ATTTGCCAATGTTCCATCGTTGTGGAATCATGGCACTGGTTGCAGCATACCTCAACTTTGTAAGTCAGATGATAGCTGTCCCTGCATTTT
GCCAGCATGTTAGCAAGGTTATTGAAATTCGAACTATGGAAGCCCCTTATTTTCTACCAGAGCATATCTTCAGAGATAAGTGCATGCTTC
CAAAATCTTTAGAGAAGCATGAAAAAGATTTGTACTTTCTGACCAACAAGATTGCAGAGTCGCTAGGTGGAAGTGGATATAGTGTTGAGA
GATTGTCAGTTCCGTATGTACCACAAGTAACAGATGAAGATCGACTTTCTAGAAGAAAAAGCATTGTGGACACCGTATCCATTCAGGTGG
ATATTTTATCCAACAATGTTCCTTCTGATGATGTGGTTAGTAACACTGAAGAAATCACTTTTGAAGCATTGAAGAAAGCAATTGATACCA
GTGGAATGGAAGAACAGGAAAAGGAAAAGAGGCGTCTTGTGATAGAGAAATTTCAGAAAGCACCTTTTGAAGAAATAGCAGCACAGTGTG
AATCCAAAGCAAATTTGCTTCATGATAGACTTGCCCAAATATTGGAACTCACCATACGTCCTCCTCCCAGTCCATCAGGAACACTGACCA
TTACTTCTGGGCATGCCCAATACCAATCTGTCCCAGTCTATGAGATGAAGTTTCCAGATCTGTGTGTGTACTGATCGGCGCATGAAGACC
TCAGGATATGATTTGTAAAGCCTAAAAATTAAGGCCAAGCTGAGCTTTCAGGGTTTACTTAATGTGTATTAACATACTTCTTGAAAATAA
TGATGGAACATATCTTTAACCAAATGTTTGGCATACCATATTAGAAGTTTTGGAGCTATATATAATTTCGAGTACTTTCAAAGATAGATT
TATGCCATGTTAATTTGCTTTGAGGTTCCTGTTGCCTTTTTAAGTTGAACATGTTTTGGTTTCACTTTATTCCACTGTTAAGTAGTATGT
TTTAAACTTTTCACAAATGTAATGTTTTTTAAAAAGTAAGCCTTCAGAGGATTGAAACTGTATAAATTGTTTATCTCTTAAACATCTACA
CAGCCGCTTAGATGTAGAATTTTTGTTGTTGTTTTCTGCAAAGGCAGATACATTTAAATATATTCCTAGTCCTGGGACTGCAAAACTGTT
CGGTGGCTTTTTGTCCCCATGCTTTAGATAAGCTGGGATAGGCACCTTGCTATTCAGTTACTATAATAATATGTGATAGGCATTCCTCAT
CTTCTTCACAATAATAGGACATCTGTTGAATAGCATTCCTCGAATATAACCCTAAAAACGCCATACTTTAAATTGTCTGGTTCTTGTAAT
ATTGTGTTTCCTGCCAAGAGTTTGACCATTCTGCTTGAGAAGTGTAGAGCTTACTCTTGGAGTACCAAACTGTGCAATATTTTTACATCA
TAAGATGTATTAGTTTACAGGCTGTGCTTTGAAATTATAGTAGTATTTTGCTGTGGCTCCATTAATTAAATGAGATATATATTTAGTGCA
GAAAAAAGACATTTAAAACAGCTATTAGTTCACCTGTGAAGAGTCTGTACATTTTGATTTCTATTAAGAGCACATTTATTTACATTTGTA
TATTATTTTAAATCCTCATAGTCAAAAAATTCTCCAGATGGACTTTTAATTTGTAAGATTTGAACTGTGACTTGTATACATCTGTTTAGA
ATCAATTATATTTGAAAAGCTGCCTGTGTTTTAACAGTCAAGTGTGCTAAAGTTTGTCAATTTAAGCTGCTTTTGATTTCAGCTACCAAG
ATCACAGGTGCACTCTACACATAACACTGACAGACCCATAACATTACATACATCTTAGTGAATTCTATCACATGGTAAAATGAACAGCTT
TCTTTGTAACTCATAAAATTCTCTTAGGACATTTTTATAAAGTCACCTGTTTATAGTTCTATCTTTTCAGATTCCATTTCTTTTTACATA
AAACAGCATACATATCAAAAACTGTAGCCTAGAATACAGTTTAATTTTTGGCTTTTGTTTTTGTTTAAAAAATTGCAGTGAAGAATGGGA
TGTTTGTGTTTATGGCTATTTGGGCACCTTTAGTAGAAACAGACAAAAGTAAGGAAACGATAATAGGACAAGCATACTTGAAAATTTCTG
AATACTTAAACAAAAGCGCAACATCTTGAAAACCAGTCTAGTCATTGAAACCTATGAAATGACACTGAAAGATCCTGGGCTGCTTCTTAA
ATAAGTAGATCAGCAAGACTTGTTTCAGAGTGACAGTGGAGTCGTTACCGCTGGAGGACTAAAGGGCCCTGTGGCAGCTGTCACTGGAAC
TTTGCCTCTTGATCAGGAAAAATGCTTCACCAGTCCGTAAAGCCAAGTTGTATTTTTTTAATTGCCCTTTTTTCCTTCTGTATTTTTAAA
GAAGGATGTTAATTTTTGACTATATATTTTAAAAAAATCTAAGCAGGGGGACATGCAAAAACAATCATCATCCACTTGGATGTCATTTTA
TAGATTAACACTGTGTGCTTTTGTATGGAAAAAATATATATAATTTAATAGTATAAAAAATAAAATATATATTCATTTGCACTTACGTGA
AACACAAACTTTGCTCTACAAAATTTCGTGTTTCTTAGTGATTTTAAAATGCATGTATTGCATGTAAAGGAAAACCATTACAATTAATGT
TTATCACACCTTTATCTTGGTCTTTGTTGATTTGGGTTTTGTTGGGGTTTTTGTTACTGTTTTTAAATTACAGTAGGCTTCTATATATCC
TGGATTTCTGAACTGGTCTTGTTGACAAGGATTCCCAAGAAATGGATCTTTTCACTGGCTGACTCTCCCATATCTGCAAGAGATTCTGCA
GGAACTGGGTGTGCACACGGTGTTGTAGCCAGTTCAGGTACTGAATATTTAGGATTTGGTGAAGTTCACTGTATTGCTATATTTTTGTAG

>6954_6954_2_ASAP1-EFR3A_ASAP1_chr8_131164981_ENST00000518721_EFR3A_chr8_132952745_ENST00000334503_length(amino acids)=837AA_BP=20
MAEEEVFSQEWDSDHLTCHRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKTDMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRSGYV
LIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEI
RIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRIGPPSSPSATDKEENPAVLAENCFRELLGRATFGNMNNAV
RPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARKKDAPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKH
LRLSVEFEANDLQGGSVGSVNLNTSSKDNDEKIVQNAIIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQI
MLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMK
KNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAV
PAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHEKDLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVS
IQVDILSNNVPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ASAP1-EFR3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ASAP1-EFR3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ASAP1-EFR3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource