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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASAP1-KCNH1 (FusionGDB2 ID:6959)

Fusion Gene Summary for ASAP1-KCNH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP1-KCNH1
Fusion gene ID: 6959
HgeneTgene
Gene symbol

ASAP1

KCNH1

Gene ID

50807

3756

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 1potassium voltage-gated channel subfamily H member 1
SynonymsAMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14PEAG|EAG1|Kv10.1|TMBTS|ZLS1|h-eag|hEAG|hEAG1
Cytomap

8q24.21-q24.22

1q32.2

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosylpotassium voltage-gated channel subfamily H member 1EAG channel 1ether-a-go-go 1ether-a-go-go potassium channel 1ether-a-go-go, Drosophila, homolog ofpotassium channel, voltage gated eag related subfamily H, member 1potassium voltage-gated channel,
Modification date2020032720200313
UniProtAcc

Q9ULH1

O95259

Ensembl transtripts involved in fusion geneENST00000518721, ENST00000357668, 
ENST00000520625, 
ENST00000271751, 
ENST00000367007, 
Fusion gene scores* DoF score25 X 17 X 13=55256 X 5 X 6=180
# samples 286
** MAII scorelog2(28/5525*10)=-4.30247573222119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAP1 [Title/Abstract] AND KCNH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASAP1(131088594)-KCNH1(210977508), # samples:3
Anticipated loss of major functional domain due to fusion event.ASAP1-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASAP1-KCNH1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKCNH1

GO:0071805

potassium ion transmembrane transport

22732247|27005320|27325704


check buttonFusion gene breakpoints across ASAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01AASAP1chr8

131088594

-KCNH1chr1

210977508

-


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Fusion Gene ORF analysis for ASAP1-KCNH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000518721ENST00000271751ASAP1chr8

131088594

-KCNH1chr1

210977508

-
Frame-shiftENST00000518721ENST00000367007ASAP1chr8

131088594

-KCNH1chr1

210977508

-
In-frameENST00000357668ENST00000271751ASAP1chr8

131088594

-KCNH1chr1

210977508

-
In-frameENST00000357668ENST00000367007ASAP1chr8

131088594

-KCNH1chr1

210977508

-
intron-3CDSENST00000520625ENST00000271751ASAP1chr8

131088594

-KCNH1chr1

210977508

-
intron-3CDSENST00000520625ENST00000367007ASAP1chr8

131088594

-KCNH1chr1

210977508

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000357668ASAP1chr8131088594-ENST00000271751KCNH1chr1210977508-430527292842361402
ENST00000357668ASAP1chr8131088594-ENST00000367007KCNH1chr1210977508-428027292842361402

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357668ENST00000271751ASAP1chr8131088594-KCNH1chr1210977508-0.0009940750.999006
ENST00000357668ENST00000367007ASAP1chr8131088594-KCNH1chr1210977508-0.0010069120.9989931

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Fusion Genomic Features for ASAP1-KCNH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASAP1-KCNH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:131088594/chr1:210977508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAP1

Q9ULH1

KCNH1

O95259

FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629324_4169001130.0DomainPH
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629439_5609001130.0DomainArf-GAP
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730324_4169001130.0DomainPH
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730439_5609001130.0DomainArf-GAP
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629600_6329001130.0RepeatNote=ANK 1
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629636_6659001130.0RepeatNote=ANK 2
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730600_6329001130.0RepeatNote=ANK 1
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730636_6659001130.0RepeatNote=ANK 2
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629454_4779001130.0Zinc fingerC4-type
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730454_4779001130.0Zinc fingerC4-type
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611463_468460963.0MotifSelectivity filter
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611673_770487990.0RegionCalmodulin-binding
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611924_964487990.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611673_770460963.0RegionCalmodulin-binding
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611924_964460963.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611499_989487990.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611471_477460963.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611499_989460963.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611478_498460963.0TransmembraneHelical%3B Name%3DSegment S6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-2629783_9939001130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-2730783_9939001130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131088594chr1:210977508ENST00000357668-26291067_11299001130.0DomainSH3
HgeneASAP1chr8:131088594chr1:210977508ENST00000518721-27301067_11299001130.0DomainSH3
TgeneKCNH1chr8:131088594chr1:210977508ENST0000027175161114_94487990.0DomainPAS
TgeneKCNH1chr8:131088594chr1:210977508ENST0000027175161193_145487990.0DomainPAC
TgeneKCNH1chr8:131088594chr1:210977508ENST0000036700761114_94460963.0DomainPAS
TgeneKCNH1chr8:131088594chr1:210977508ENST0000036700761193_145460963.0DomainPAC
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611449_470487990.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611449_470460963.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611463_468487990.0MotifSelectivity filter
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611151_162487990.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611151_162460963.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr8:131088594chr1:210977508ENST000002717516111_220487990.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611242_248487990.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611270_290487990.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611310_345487990.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611369_377487990.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611400_448487990.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611471_477487990.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST000003670076111_220460963.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611242_248460963.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611270_290460963.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611310_345460963.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611369_377460963.0Topological domainCytoplasmic
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611400_448460963.0Topological domainExtracellular
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611221_241487990.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611249_269487990.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611291_309487990.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611346_368487990.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611378_399487990.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr8:131088594chr1:210977508ENST00000271751611478_498487990.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611221_241460963.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611249_269460963.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611291_309460963.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611346_368460963.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr8:131088594chr1:210977508ENST00000367007611378_399460963.0TransmembraneHelical%3B Name%3DSegment S5


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Fusion Gene Sequence for ASAP1-KCNH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6959_6959_1_ASAP1-KCNH1_ASAP1_chr8_131088594_ENST00000357668_KCNH1_chr1_210977508_ENST00000271751_length(transcript)=4305nt_BP=2729nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTGAAGAAGTCTGTAAAAGCAAT
ATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGTAATTTTTTAAGTCGAGACAA
CCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAATCTGCTCCAGGGTTTGAGCCA
CAATGTGATCTTCACCTTGGATTCTTTGTTAAAAGGAGACCTAAAGGGAGTCAAAGGAGATCTCAAGAAGCCATTTGACAAAGCCTGGAA
AGATTATGAGACAAAGTTTACAAAAATTGAGAAAGAGAAAAGAGAGCACGCAAAACAACATGGGATGATCCGCACAGAGATAACAGGAGC
TGAGATTGCGGAAGAAATGGAGAAGGAAAGGCGCCTCTTTCAGCTCCAAATGTGTGAATATCTCATTAAAGTTAATGAAATCAAGACCAA
AAAGGGTGTGGATCTGCTGCAGAATCTTATAAAGTATTACCATGCACAGTGCAATTTCTTTCAAGATGGCTTGAAAACAGCTGATAAGTT
GAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAACAGCTAACTGCACTCCGAGA
CTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATGCATCAGCTCCAGGGCAATAA
GGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGGAGGAAGTGTTCAGTCAAGAA
TGGGATTCTGACCATCTCACATGCCACATCTAACAGGCAACCAGCCAAGTTGAACCTTCTCACCTGCCAAGTAAAACCTAATGCCGAAGA
CAAAAAATCTTTTGACCTGATATCACATAATAGAACATATCACTTTCAGGCAGAAGATGAGCAGGATTATGTAGCATGGATATCAGTATT
GACAAATAGCAAAGAAGAGGCCCTAACCATGGCCTTCCGTGGAGAGCAGAGTGCGGGAGAGAACAGCCTGGAAGACCTGACAAAAGCCAT
TATTGAGGATGTCCAGCGGCTCCCAGGGAATGACATTTGCTGCGATTGTGGCTCATCAGAACCCACCTGGCTTTCAACCAACTTGGGTAT
TTTGACCTGTATAGAATGTTCTGGCATCCATAGGGAAATGGGGGTTCATATTTCTCGCATTCAGTCTTTGGAACTAGACAAATTAGGAAC
TTCTGAACTCTTGCTGGCCAAGAATGTAGGAAACAATAGTTTTAATGATATTATGGAAGCAAATTTACCCAGCCCCTCACCAAAACCCAC
CCCTTCAAGTGATATGACTGTACGAAAAGAATATATCACTGCAAAGTATGTAGATCATAGGTTTTCAAGGAAGACCTGTTCAACTTCATC
AGCTAAACTAAATGAATTGCTTGAGGCCATCAAATCCAGGGATTTACTTGCACTAATTCAAGTCTATGCAGAAGGGGTAGAGCTAATGGA
ACCACTGCTGGAACCTGGGCAGGAGCTTGGGGAGACAGCCCTTCACCTTGCCGTCCGAACTGCAGATCAGACATCTCTCCATTTGGTTGA
CTTCCTTGTACAAAACTGTGGGAACCTGGATAAGCAGACGGCCCTGGGAAACACAGTTCTACACTACTGTAGTATGTACAGTAAACCTGA
GTGTTTGAAGCTTTTGCTCAGGAGCAAGCCCACTGTGGATATAGTTAACCAGGCTGGAGAAACTGCCCTAGACATAGCAAAGAGACTAAA
AGCTACCCAGTGTGAAGATCTGCTTTCCCAGGCTAAATCTGGAAAGTTCAATCCACACGTCCACGTAGAATATGAGTGGAATCTTCGACA
GGAGGAGATAGATGAGAGCGATGATGATCTGGATGACAAACCAAGCCCTATCAAGAAAGAGCGCTCACCCAGACCTCAGAGCTTCTGCCA
CTCCTCCAGCATCTCCCCCCAGGACAAGCTGGCACTGCCAGGATTCAGCACTCCAAGGGACAAACAGCGGCTCTCCTATGGAGCCTTCAC
CAACCAGATCTTCGTTTCCACAAGCACAGACTCGCCCACATCACCAACCACGGAGGCTCCCCCTCTGCCTCCTAGGAACGCCGGGAAAGG
TCCAACTGGCCCACCTTCAACACTCCCTCTAAGCACCCAGACCTCTAGTGGCAGCTCCACCCTATCCAAGAAGAGGCCTCCTCCCCCACC
ACCCGGACACAAGAGAACCCTATCCGACCCTCCCAGCCCACTACCTCATGGGCCCCCAAACAAAGGCGCAGTTCCTTGGGGTAACGATGG
GGGTCCATCCTCTTCAAGTAAGACTACAAACAAGTTTGAGGGACTATCCCAGCAGTCGAGCACCAGTTCTGCAAAGACTGCCCTTGGCCC
AAGAGTTCTTCCTAAACTACCTCAGAAAGCACTTCTCTATGCCACCATCTTCGGGAATGTGACGACTATTTTCCAACAGATGTATGCCAA
CACCAACAGATACCATGAGATGCTCAACAGTGTTCGGGACTTCCTGAAGCTCTACCAGGTGCCAAAAGGATTGAGTGAGCGAGTAATGGA
TTATATTGTGTCCACTTGGTCCATGTCCAGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCCAAGGACATGAGAGCCGACATCTG
CGTGCACCTGAACCGCAAGGTGTTCAAGGAGCACCCGGCCTTCCGGCTGGCCAGTGATGGCTGCCTCCGGGCACTGGCCATGGAGTTCCA
GACGGTGCACTGTGCCCCAGGGGACCTCATCTACCATGCAGGAGAGAGCGTTGACAGCCTCTGCTTTGTGGTTTCTGGCTCCCTGGAGGT
GATCCAAGATGATGAGGTGGTGGCCATTCTAGGAAAAGGAGACGTGTTTGGAGATGTGTTCTGGAAGGAAGCCACCCTTGCCCAGTCCTG
TGCCAATGTTAGGGCCTTGACCTACTGTGATCTGCATGTGATCAAGCGGGATGCCCTGCAGAAAGTGCTGGAATTCTACACGGCCTTCTC
CCATTCCTTCTCCCGGAACCTGATTCTGACGTACAACTTGAGGAAGAGGATTGTGTTCCGGAAGATCAGCGATGTGAAACGTGAAGAGGA
AGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCAGAGATTCCGACAGCAGAA
AGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGC
CAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGCAGCCTCCACCTCCGGGGT
GCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGC
CCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACTTCCCGAGAGGACAAAAGC
GTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAG
GAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCTGCAGGCCACAGTCCTGGA
GGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATTGAGAAACAGCTCTCTGAGATACTCAGGATATT
AACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGAGAGAGACATTTTTGGAGC

>6959_6959_1_ASAP1-KCNH1_ASAP1_chr8_131088594_ENST00000357668_KCNH1_chr1_210977508_ENST00000271751_length(amino acids)=1402AA_BP=900
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQ
NEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAA
DLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPG
NDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNL
DKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLP
LSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
ALLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFK
EHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYC
DLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERG
GRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKS
EDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDI

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>6959_6959_2_ASAP1-KCNH1_ASAP1_chr8_131088594_ENST00000357668_KCNH1_chr1_210977508_ENST00000367007_length(transcript)=4280nt_BP=2729nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTGAAGAAGTCTGTAAAAGCAAT
ATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGTAATTTTTTAAGTCGAGACAA
CCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAATCTGCTCCAGGGTTTGAGCCA
CAATGTGATCTTCACCTTGGATTCTTTGTTAAAAGGAGACCTAAAGGGAGTCAAAGGAGATCTCAAGAAGCCATTTGACAAAGCCTGGAA
AGATTATGAGACAAAGTTTACAAAAATTGAGAAAGAGAAAAGAGAGCACGCAAAACAACATGGGATGATCCGCACAGAGATAACAGGAGC
TGAGATTGCGGAAGAAATGGAGAAGGAAAGGCGCCTCTTTCAGCTCCAAATGTGTGAATATCTCATTAAAGTTAATGAAATCAAGACCAA
AAAGGGTGTGGATCTGCTGCAGAATCTTATAAAGTATTACCATGCACAGTGCAATTTCTTTCAAGATGGCTTGAAAACAGCTGATAAGTT
GAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAACAGCTAACTGCACTCCGAGA
CTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATGCATCAGCTCCAGGGCAATAA
GGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGGAGGAAGTGTTCAGTCAAGAA
TGGGATTCTGACCATCTCACATGCCACATCTAACAGGCAACCAGCCAAGTTGAACCTTCTCACCTGCCAAGTAAAACCTAATGCCGAAGA
CAAAAAATCTTTTGACCTGATATCACATAATAGAACATATCACTTTCAGGCAGAAGATGAGCAGGATTATGTAGCATGGATATCAGTATT
GACAAATAGCAAAGAAGAGGCCCTAACCATGGCCTTCCGTGGAGAGCAGAGTGCGGGAGAGAACAGCCTGGAAGACCTGACAAAAGCCAT
TATTGAGGATGTCCAGCGGCTCCCAGGGAATGACATTTGCTGCGATTGTGGCTCATCAGAACCCACCTGGCTTTCAACCAACTTGGGTAT
TTTGACCTGTATAGAATGTTCTGGCATCCATAGGGAAATGGGGGTTCATATTTCTCGCATTCAGTCTTTGGAACTAGACAAATTAGGAAC
TTCTGAACTCTTGCTGGCCAAGAATGTAGGAAACAATAGTTTTAATGATATTATGGAAGCAAATTTACCCAGCCCCTCACCAAAACCCAC
CCCTTCAAGTGATATGACTGTACGAAAAGAATATATCACTGCAAAGTATGTAGATCATAGGTTTTCAAGGAAGACCTGTTCAACTTCATC
AGCTAAACTAAATGAATTGCTTGAGGCCATCAAATCCAGGGATTTACTTGCACTAATTCAAGTCTATGCAGAAGGGGTAGAGCTAATGGA
ACCACTGCTGGAACCTGGGCAGGAGCTTGGGGAGACAGCCCTTCACCTTGCCGTCCGAACTGCAGATCAGACATCTCTCCATTTGGTTGA
CTTCCTTGTACAAAACTGTGGGAACCTGGATAAGCAGACGGCCCTGGGAAACACAGTTCTACACTACTGTAGTATGTACAGTAAACCTGA
GTGTTTGAAGCTTTTGCTCAGGAGCAAGCCCACTGTGGATATAGTTAACCAGGCTGGAGAAACTGCCCTAGACATAGCAAAGAGACTAAA
AGCTACCCAGTGTGAAGATCTGCTTTCCCAGGCTAAATCTGGAAAGTTCAATCCACACGTCCACGTAGAATATGAGTGGAATCTTCGACA
GGAGGAGATAGATGAGAGCGATGATGATCTGGATGACAAACCAAGCCCTATCAAGAAAGAGCGCTCACCCAGACCTCAGAGCTTCTGCCA
CTCCTCCAGCATCTCCCCCCAGGACAAGCTGGCACTGCCAGGATTCAGCACTCCAAGGGACAAACAGCGGCTCTCCTATGGAGCCTTCAC
CAACCAGATCTTCGTTTCCACAAGCACAGACTCGCCCACATCACCAACCACGGAGGCTCCCCCTCTGCCTCCTAGGAACGCCGGGAAAGG
TCCAACTGGCCCACCTTCAACACTCCCTCTAAGCACCCAGACCTCTAGTGGCAGCTCCACCCTATCCAAGAAGAGGCCTCCTCCCCCACC
ACCCGGACACAAGAGAACCCTATCCGACCCTCCCAGCCCACTACCTCATGGGCCCCCAAACAAAGGCGCAGTTCCTTGGGGTAACGATGG
GGGTCCATCCTCTTCAAGTAAGACTACAAACAAGTTTGAGGGACTATCCCAGCAGTCGAGCACCAGTTCTGCAAAGACTGCCCTTGGCCC
AAGAGTTCTTCCTAAACTACCTCAGAAAGCACTTCTCTATGCCACCATCTTCGGGAATGTGACGACTATTTTCCAACAGATGTATGCCAA
CACCAACAGATACCATGAGATGCTCAACAGTGTTCGGGACTTCCTGAAGCTCTACCAGGTGCCAAAAGGATTGAGTGAGCGAGTAATGGA
TTATATTGTGTCCACTTGGTCCATGTCCAGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCCAAGGACATGAGAGCCGACATCTG
CGTGCACCTGAACCGCAAGGTGTTCAAGGAGCACCCGGCCTTCCGGCTGGCCAGTGATGGCTGCCTCCGGGCACTGGCCATGGAGTTCCA
GACGGTGCACTGTGCCCCAGGGGACCTCATCTACCATGCAGGAGAGAGCGTTGACAGCCTCTGCTTTGTGGTTTCTGGCTCCCTGGAGGT
GATCCAAGATGATGAGGTGGTGGCCATTCTAGGAAAAGGAGACGTGTTTGGAGATGTGTTCTGGAAGGAAGCCACCCTTGCCCAGTCCTG
TGCCAATGTTAGGGCCTTGACCTACTGTGATCTGCATGTGATCAAGCGGGATGCCCTGCAGAAAGTGCTGGAATTCTACACGGCCTTCTC
CCATTCCTTCTCCCGGAACCTGATTCTGACGTACAACTTGAGGAAGAGGATTGTGTTCCGGAAGATCAGCGATGTGAAACGTGAAGAGGA
AGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCAGAGATTCCGACAGCAGAA
AGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGC
CAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGCAGCCTCCACCTCCGGGGT
GCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGC
CCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACTTCCCGAGAGGACAAAAGC
GTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAG
GAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCTGCAGGCCACAGTCCTGGA
GGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATTGAGAAACAGCTCTCTGAGATACTCAGGATATT
AACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGAGAGAGACATTTTTGGAGC

>6959_6959_2_ASAP1-KCNH1_ASAP1_chr8_131088594_ENST00000357668_KCNH1_chr1_210977508_ENST00000367007_length(amino acids)=1402AA_BP=900
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQ
NEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAA
DLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPG
NDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNL
DKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLP
LSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
ALLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFK
EHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYC
DLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERG
GRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKS
EDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDI

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Fusion Gene PPI Analysis for ASAP1-KCNH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASAP1-KCNH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASAP1-KCNH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource