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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMD12-SEC24B (FusionGDB2 ID:69653)

Fusion Gene Summary for PSMD12-SEC24B

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD12-SEC24B
Fusion gene ID: 69653
HgeneTgene
Gene symbol

PSMD12

SEC24B

Gene ID

5718

10427

Gene nameproteasome 26S subunit, non-ATPase 12SEC24 homolog B, COPII coat complex component
SynonymsRpn5|STISS|p55SEC24
Cytomap

17q24.2

4q25

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 1226S proteasome regulatory subunit RPN526S proteasome regulatory subunit p55proteasome (prosome, macropain) 26S subunit, non-ATPase, 12protein transport protein Sec24BSEC24 related gene family, member Bsecretory protein 24
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000581618, ENST00000356126, 
ENST00000357146, 		ENST00000265175, 
ENST00000399100, ENST00000504968, 
Fusion gene scores* DoF score6 X 6 X 3=10811 X 10 X 4=440
# samples 911
** MAII scorelog2(9/108*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD12 [Title/Abstract] AND SEC24B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMD12(65362528)-SEC24B(110427487), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSEC24B

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across PSMD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC24B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-RR-A6KC-01APSMD12chr17

65362528

-SEC24Bchr4

110427487

+


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Fusion Gene ORF analysis for PSMD12-SEC24B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000581618ENST00000265175PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
5UTR-3CDSENST00000581618ENST00000399100PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
5UTR-3CDSENST00000581618ENST00000504968PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000356126ENST00000265175PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000356126ENST00000399100PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000356126ENST00000504968PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000357146ENST00000265175PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000357146ENST00000399100PSMD12chr17

65362528

-SEC24Bchr4

110427487

+
In-frameENST00000357146ENST00000504968PSMD12chr17

65362528

-SEC24Bchr4

110427487

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356126PSMD12chr1765362528-ENST00000504968SEC24Bchr4110427487+2603216182531837
ENST00000356126PSMD12chr1765362528-ENST00000399100SEC24Bchr4110427487+2556216182534838
ENST00000356126PSMD12chr1765362528-ENST00000265175SEC24Bchr4110427487+3756216182534838
ENST00000357146PSMD12chr1765362528-ENST00000504968SEC24Bchr4110427487+2581194862509807
ENST00000357146PSMD12chr1765362528-ENST00000399100SEC24Bchr4110427487+2534194862512808
ENST00000357146PSMD12chr1765362528-ENST00000265175SEC24Bchr4110427487+3734194862512808

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356126ENST00000504968PSMD12chr1765362528-SEC24Bchr4110427487+0.0009655520.9990345
ENST00000356126ENST00000399100PSMD12chr1765362528-SEC24Bchr4110427487+0.0014611180.99853885
ENST00000356126ENST00000265175PSMD12chr1765362528-SEC24Bchr4110427487+0.000747610.9992524
ENST00000357146ENST00000504968PSMD12chr1765362528-SEC24Bchr4110427487+0.0009607390.9990393
ENST00000357146ENST00000399100PSMD12chr1765362528-SEC24Bchr4110427487+0.0014420670.998558
ENST00000357146ENST00000265175PSMD12chr1765362528-SEC24Bchr4110427487+0.0007394140.9992606

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Fusion Genomic Features for PSMD12-SEC24B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMD12chr1765362527-SEC24Bchr4110427483+8.36E-080.9999999
PSMD12chr1765362527-SEC24Bchr4110427483+8.36E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSMD12-SEC24B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65362528/chr4:110427487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEC24Bchr17:65362528chr4:110427487ENST00000265175524605_6294961269.0RegionNote=Zinc finger-like
TgeneSEC24Bchr17:65362528chr4:110427487ENST00000399100423605_6294611234.0RegionNote=Zinc finger-like
TgeneSEC24Bchr17:65362528chr4:110427487ENST000002651755241141_12134961269.0RepeatGelsolin-like
TgeneSEC24Bchr17:65362528chr4:110427487ENST000003991004231141_12134611234.0RepeatGelsolin-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD12chr17:65362528chr4:110427487ENST00000356126-111242_42036457.0DomainPCI
HgenePSMD12chr17:65362528chr4:110427487ENST00000357146-110242_42036437.0DomainPCI
TgeneSEC24Bchr17:65362528chr4:110427487ENST00000265175524379_3874961269.0Compositional biasNote=Poly-Glu
TgeneSEC24Bchr17:65362528chr4:110427487ENST00000399100423379_3874611234.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for PSMD12-SEC24B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69653_69653_1_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000265175_length(transcript)=3756nt_BP=216nt
GCGTGGGCTCCCGATGGGCTGCCTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGG
GACGCTCAGGCGGGGACCATGGCGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTG
GATCAGCGCCTACCCGAGTGTGCGAAGCTAGCCAAGCAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAG
AGTTCTCCACAACCAGAAAGCCTGAGACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCT
AACTTGAATGCAGACCTCAAAAAATTAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTG
AATAAAGCTAAGCTTCCTTTAGGATTGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGG
TGCCGATCCTGTCGAACGTATATTAACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGAT
GTTCCTGAAGAATTTATGTATAACCCCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTC
ATTGCTTCTTCAGATTACATGCTGCGTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGA
TATTTGACAATTTTGTGCCAGTCACTCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGAT
AGCACTATTCATTTCTACAATTTACAAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACA
CCGGATAGTTTACTTGTGAATCTATATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGA
GAAACACACAGTGCCCTTGGTCCTGCACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAG
TTACCTTCCTTGGGTGCAGGACTTCTGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCA
ACTGATTTTTATAAGAAACTTGCATTAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTT
GCTTCTCTAGCTTGCATGTCCAAGTATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAA
AAGTTACAAAAAGACCTAAAACGGTATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATG
CACACTTTTCACGGTAACTTCTTTGTCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTG
TCAATTGAAGAAAGTTTAACAGATACTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGA
GTACATACACTTTGTTTGCCAGTGGTAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAAC
ATGGCTGTGGATCGGTCCGTTTCATCAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGC
TCAACTGTCTCAAATTTACAGCACTCTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAG
AAAGCATTTAGAACGGGTACAAGCACACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATG
AAAATGATTCATCCCAACTTATACAGGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCT
CTTCAAAAATTGTCTGCAGAGAAGCTGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGC
TGTGACAATAACTTCATAGAGGATGTGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACA
CTTTCATCAGAAAGAGCCAGATCCTTCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGT
CCTGCCAAAGCAGAATTTTTTCAGCATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAG
CAGATTTGTAAGTGAAGTAGAATAAAATTGAATAAGAAAAAGATCTATAACCTAGGTAAAGCATAATCTGTCAGAGAAGCGCGTGAGAAA
TTTGAAATGAAGGCATTTGTTAATACAAGATGCAACGCACAGCACTCTGTCTGAGGCTTTGGTAAAAAGTAAAGGGGAAGAAAGAACTTG
ACAGATCTTTTTCAACTCAAATTAATGGTAACGATGATGCTGTTTCACCAAGTATATTTTGAATTGGTTTCTACACATTTCCAGTAGTAT
GGCAGTACAGTGCTCTGTTCATTGCAAGCTGGCAAATTTATGTAGCTATGTGGAATGATATGTCATAATGTAAAATTAGATAAATTCTTT
TTTCTTATAATTAATATAACATTTCTGGACTTGAACTCTGGCAAGAGATGCCAAAAGGCATTGGTACCGTGTTATTTGTTTATATGAATT
ACTTTTTAACAAGGAATGTTTCTTATTCATTAAATGAATTCAACATTTTCTCTGTAAAAACAATAGAGTTTCAGTACATGAACTATAGAA
AAAAATCTATATATAATGTACATAAATGTTACATTTGTAAAGAAAATGTAAAAATGTAACTATAGCATATGAATTGCTTAAACTGTGCTG
CATTGTTGGATGACAACTCTTTTTGTCACAGTTAGAGAATGAGGTTGACTAATGCATATTATGAATTGAGTCCACAAAGGAACACAAAAC
TCTTTGTAATTCTGTTAAATCTTTTATGTAGATTTATTTATGATCAGCCTACTAATTAAAACTATTTCGCTTGACAGTATGGTTTGGTGA
TTTTTTGGGGTTTTTGTTTGATTGGTTTTTTGTGGGGATTGGTGGGTTTTTTTACATACAGGATGTATTGAATTTACTAATTGGGGAAGT
GCAGTGATACTGCATTTCAGTTAGTAATATATATGAATCAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGGCCAA
GGTGGGCAGATGACTTGAGGTCAGGTGTTCATGACCTGCCTGACCAACATGATGAAACCCCATCTCTGCTAAAAATACCAAAATTAGCCA
GGGGTGCTGGCGGGCACCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGTAGAATCGCTTGAACCTGGAGGCTGAGGTTGCAGTGAGCT

>69653_69653_1_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000265175_length(amino acids)=838AA_BP=66
MPERVRGQLPVWVTSGGRSRGTARDAQAGTMADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKQYPGVNQLSSSIGGLSLQSSPQPE
SLRPVNLTQERNILPMTPVWAPVPNLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRT
YINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILC
QSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSAL
GPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACM
SKYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESL
TDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNL
QHSALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSA
EKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEF

--------------------------------------------------------------
>69653_69653_2_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000399100_length(transcript)=2556nt_BP=216nt
GCGTGGGCTCCCGATGGGCTGCCTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGG
GACGCTCAGGCGGGGACCATGGCGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTG
GATCAGCGCCTACCCGAGTGTGCGAAGCTAGCCAAGCAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAG
AGTTCTCCACAACCAGAAAGCCTGAGACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCT
AACTTGAATGCAGACCTCAAAAAATTAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTG
AATAAAGCTAAGCTTCCTTTAGGATTGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGG
TGCCGATCCTGTCGAACGTATATTAACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGAT
GTTCCTGAAGAATTTATGTATAACCCCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTC
ATTGCTTCTTCAGATTACATGCTGCGTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGA
TATTTGACAATTTTGTGCCAGTCACTCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGAT
AGCACTATTCATTTCTACAATTTACAAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACA
CCGGATAGTTTACTTGTGAATCTATATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGA
GAAACACACAGTGCCCTTGGTCCTGCACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAG
TTACCTTCCTTGGGTGCAGGACTTCTGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCA
ACTGATTTTTATAAGAAACTTGCATTAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTT
GCTTCTCTAGCTTGCATGTCCAAGTATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAA
AAGTTACAAAAAGACCTAAAACGGTATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATG
CACACTTTTCACGGTAACTTCTTTGTCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTG
TCAATTGAAGAAAGTTTAACAGATACTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGA
GTACATACACTTTGTTTGCCAGTGGTAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAAC
ATGGCTGTGGATCGGTCCGTTTCATCAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGC
TCAACTGTCTCAAATTTACAGCACTCTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAG
AAAGCATTTAGAACGGGTACAAGCACACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATG
AAAATGATTCATCCCAACTTATACAGGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCT
CTTCAAAAATTGTCTGCAGAGAAGCTGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGC
TGTGACAATAACTTCATAGAGGATGTGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACA
CTTTCATCAGAAAGAGCCAGATCCTTCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGT
CCTGCCAAAGCAGAATTTTTTCAGCATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAG

>69653_69653_2_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000399100_length(amino acids)=838AA_BP=66
MPERVRGQLPVWVTSGGRSRGTARDAQAGTMADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKQYPGVNQLSSSIGGLSLQSSPQPE
SLRPVNLTQERNILPMTPVWAPVPNLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRT
YINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILC
QSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSAL
GPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACM
SKYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESL
TDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNL
QHSALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSA
EKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEF

--------------------------------------------------------------
>69653_69653_3_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000504968_length(transcript)=2603nt_BP=216nt
GCGTGGGCTCCCGATGGGCTGCCTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGG
GACGCTCAGGCGGGGACCATGGCGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTG
GATCAGCGCCTACCCGAGTGTGCGAAGCTAGCCAAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAGAGT
TCTCCACAACCAGAAAGCCTGAGACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCTAAC
TTGAATGCAGACCTCAAAAAATTAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTGAAT
AAAGCTAAGCTTCCTTTAGGATTGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGGTGC
CGATCCTGTCGAACGTATATTAACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGATGTT
CCTGAAGAATTTATGTATAACCCCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTCATT
GCTTCTTCAGATTACATGCTGCGTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGATAT
TTGACAATTTTGTGCCAGTCACTCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGATAGC
ACTATTCATTTCTACAATTTACAAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACACCG
GATAGTTTACTTGTGAATCTATATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGAGAA
ACACACAGTGCCCTTGGTCCTGCACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAGTTA
CCTTCCTTGGGTGCAGGACTTCTGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCAACT
GATTTTTATAAGAAACTTGCATTAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTTGCT
TCTCTAGCTTGCATGTCCAAGTATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAAAAG
TTACAAAAAGACCTAAAACGGTATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATGCAC
ACTTTTCACGGTAACTTCTTTGTCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTGTCA
ATTGAAGAAAGTTTAACAGATACTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGAGTA
CATACACTTTGTTTGCCAGTGGTAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAACATG
GCTGTGGATCGGTCCGTTTCATCAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGCTCA
ACTGTCTCAAATTTACAGCACTCTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAGAAA
GCATTTAGAACGGGTACAAGCACACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATGAAA
ATGATTCATCCCAACTTATACAGGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCTCTT
CAAAAATTGTCTGCAGAGAAGCTGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGCTGT
GACAATAACTTCATAGAGGATGTGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACACTT
TCATCAGAAAGAGCCAGATCCTTCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGTCCT
GCCAAAGCAGAATTTTTTCAGCATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAGCAG

>69653_69653_3_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000356126_SEC24B_chr4_110427487_ENST00000504968_length(amino acids)=837AA_BP=66
MPERVRGQLPVWVTSGGRSRGTARDAQAGTMADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKYPGVNQLSSSIGGLSLQSSPQPES
LRPVNLTQERNILPMTPVWAPVPNLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTY
INPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQ
SLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALG
PALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMS
KYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLT
DTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQ
HSALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSAE
KLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEFF

--------------------------------------------------------------
>69653_69653_4_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000265175_length(transcript)=3734nt_BP=194nt
CTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGGGACGCTCAGGCGGGGACCATGG
CGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTGGATCAGCGCCTACCCGAGTGTG
CGAAGCTAGCCAAGCAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAGAGTTCTCCACAACCAGAAAGCC
TGAGACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCTAACTTGAATGCAGACCTCAAAA
AATTAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTGAATAAAGCTAAGCTTCCTTTAG
GATTGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGGTGCCGATCCTGTCGAACGTATA
TTAACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGATGTTCCTGAAGAATTTATGTATA
ACCCCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTCATTGCTTCTTCAGATTACATGC
TGCGTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGATATTTGACAATTTTGTGCCAGT
CACTCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGATAGCACTATTCATTTCTACAATT
TACAAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACACCGGATAGTTTACTTGTGAATC
TATATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGAGAAACACACAGTGCCCTTGGTC
CTGCACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAGTTACCTTCCTTGGGTGCAGGAC
TTCTGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCAACTGATTTTTATAAGAAACTTG
CATTAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTTGCTTCTCTAGCTTGCATGTCCA
AGTATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAAAAGTTACAAAAAGACCTAAAAC
GGTATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATGCACACTTTTCACGGTAACTTCT
TTGTCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTGTCAATTGAAGAAAGTTTAACAG
ATACTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGAGTACATACACTTTGTTTGCCAG
TGGTAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAACATGGCTGTGGATCGGTCCGTTT
CATCAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGCTCAACTGTCTCAAATTTACAGC
ACTCTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAGAAAGCATTTAGAACGGGTACAA
GCACACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATGAAAATGATTCATCCCAACTTAT
ACAGGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCTCTTCAAAAATTGTCTGCAGAGA
AGCTGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGCTGTGACAATAACTTCATAGAGG
ATGTGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACACTTTCATCAGAAAGAGCCAGAT
CCTTCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGTCCTGCCAAAGCAGAATTTTTTC
AGCATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAGCAGATTTGTAAGTGAAGTAGAA
TAAAATTGAATAAGAAAAAGATCTATAACCTAGGTAAAGCATAATCTGTCAGAGAAGCGCGTGAGAAATTTGAAATGAAGGCATTTGTTA
ATACAAGATGCAACGCACAGCACTCTGTCTGAGGCTTTGGTAAAAAGTAAAGGGGAAGAAAGAACTTGACAGATCTTTTTCAACTCAAAT
TAATGGTAACGATGATGCTGTTTCACCAAGTATATTTTGAATTGGTTTCTACACATTTCCAGTAGTATGGCAGTACAGTGCTCTGTTCAT
TGCAAGCTGGCAAATTTATGTAGCTATGTGGAATGATATGTCATAATGTAAAATTAGATAAATTCTTTTTTCTTATAATTAATATAACAT
TTCTGGACTTGAACTCTGGCAAGAGATGCCAAAAGGCATTGGTACCGTGTTATTTGTTTATATGAATTACTTTTTAACAAGGAATGTTTC
TTATTCATTAAATGAATTCAACATTTTCTCTGTAAAAACAATAGAGTTTCAGTACATGAACTATAGAAAAAAATCTATATATAATGTACA
TAAATGTTACATTTGTAAAGAAAATGTAAAAATGTAACTATAGCATATGAATTGCTTAAACTGTGCTGCATTGTTGGATGACAACTCTTT
TTGTCACAGTTAGAGAATGAGGTTGACTAATGCATATTATGAATTGAGTCCACAAAGGAACACAAAACTCTTTGTAATTCTGTTAAATCT
TTTATGTAGATTTATTTATGATCAGCCTACTAATTAAAACTATTTCGCTTGACAGTATGGTTTGGTGATTTTTTGGGGTTTTTGTTTGAT
TGGTTTTTTGTGGGGATTGGTGGGTTTTTTTACATACAGGATGTATTGAATTTACTAATTGGGGAAGTGCAGTGATACTGCATTTCAGTT
AGTAATATATATGAATCAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGGCCAAGGTGGGCAGATGACTTGAGGTC
AGGTGTTCATGACCTGCCTGACCAACATGATGAAACCCCATCTCTGCTAAAAATACCAAAATTAGCCAGGGGTGCTGGCGGGCACCTGTA
ATCCCAGCTACTCAGGAGGCTGAAGCAGTAGAATCGCTTGAACCTGGAGGCTGAGGTTGCAGTGAGCTAAGATCACGCCACTGCACTCCA

>69653_69653_4_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000265175_length(amino acids)=808AA_BP=36
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKQYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNLNADL
KKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFM
YNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFY
NLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGA
GLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDL
KRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCL
PVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTG
TSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFI

--------------------------------------------------------------
>69653_69653_5_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000399100_length(transcript)=2534nt_BP=194nt
CTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGGGACGCTCAGGCGGGGACCATGG
CGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTGGATCAGCGCCTACCCGAGTGTG
CGAAGCTAGCCAAGCAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAGAGTTCTCCACAACCAGAAAGCC
TGAGACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCTAACTTGAATGCAGACCTCAAAA
AATTAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTGAATAAAGCTAAGCTTCCTTTAG
GATTGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGGTGCCGATCCTGTCGAACGTATA
TTAACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGATGTTCCTGAAGAATTTATGTATA
ACCCCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTCATTGCTTCTTCAGATTACATGC
TGCGTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGATATTTGACAATTTTGTGCCAGT
CACTCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGATAGCACTATTCATTTCTACAATT
TACAAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACACCGGATAGTTTACTTGTGAATC
TATATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGAGAAACACACAGTGCCCTTGGTC
CTGCACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAGTTACCTTCCTTGGGTGCAGGAC
TTCTGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCAACTGATTTTTATAAGAAACTTG
CATTAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTTGCTTCTCTAGCTTGCATGTCCA
AGTATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAAAAGTTACAAAAAGACCTAAAAC
GGTATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATGCACACTTTTCACGGTAACTTCT
TTGTCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTGTCAATTGAAGAAAGTTTAACAG
ATACTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGAGTACATACACTTTGTTTGCCAG
TGGTAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAACATGGCTGTGGATCGGTCCGTTT
CATCAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGCTCAACTGTCTCAAATTTACAGC
ACTCTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAGAAAGCATTTAGAACGGGTACAA
GCACACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATGAAAATGATTCATCCCAACTTAT
ACAGGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCTCTTCAAAAATTGTCTGCAGAGA
AGCTGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGCTGTGACAATAACTTCATAGAGG
ATGTGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACACTTTCATCAGAAAGAGCCAGAT
CCTTCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGTCCTGCCAAAGCAGAATTTTTTC
AGCATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAGCAGATTTGTAAGTGAAGTAGAA

>69653_69653_5_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000399100_length(amino acids)=808AA_BP=36
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKQYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNLNADL
KKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFM
YNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFY
NLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGA
GLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDL
KRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCL
PVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTG
TSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFI

--------------------------------------------------------------
>69653_69653_6_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000504968_length(transcript)=2581nt_BP=194nt
CTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGGGACGCTCAGGCGGGGACCATGG
CGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTGGATCAGCGCCTACCCGAGTGTG
CGAAGCTAGCCAAGTATCCTGGTGTGAACCAGCTATCCTCCAGTATAGGAGGATTGAGTCTTCAGAGTTCTCCACAACCAGAAAGCCTGA
GACCTGTAAACCTTACTCAGGAGAGGAATATTTTACCTATGACTCCTGTTTGGGCTCCTGTACCTAACTTGAATGCAGACCTCAAAAAAT
TAAACTGTAGCCCAGATTCATTTCGGTGTACTTTGACAAATATTCCACAGACACAGGCTTTACTGAATAAAGCTAAGCTTCCTTTAGGAT
TGTTGTTACATCCCTTCAGAGACCTAACGCAATTACCAGTGATAACATCAAATACCATTGTGAGGTGCCGATCCTGTCGAACGTATATTA
ACCCCTTTGTATCCTTCATTGATCAACGTAGATGGAAATGCAATTTGTGCTATAGAGTAAACGATGTTCCTGAAGAATTTATGTATAACC
CCCTTACCCGATCTTATGGAGAGCCTCATAAACGACCAGAAGTTCAGAATTCAACTGTGGAGTTCATTGCTTCTTCAGATTACATGCTGC
GTCCTCCTCAACCTGCAGTTTACTTGTTTGTTTTAGATGTGTCTCATAATGCAGTGGAAGCTGGATATTTGACAATTTTGTGCCAGTCAC
TCCTAGAAAATCTAGACAAGCTTCCTGGAGATTCACGAACAAGAATAGGATTCATGACCTTTGATAGCACTATTCATTTCTACAATTTAC
AAGAAGGATTATCACAGCCTCAAATGTTGATTGTGTCTGATATAGATGATGTTTTTCTACCTACACCGGATAGTTTACTTGTGAATCTAT
ATGAAAGTAAAGAGCTTATAAAAGACTTACTGAATGCATTACCAAACATGTTCACCAATACAAGAGAAACACACAGTGCCCTTGGTCCTG
CACTTCAGGCTGCCTTTAAATTAATGTCTCCAACAGGTGGCCGTGTGTCTGTATTTCAGACACAGTTACCTTCCTTGGGTGCAGGACTTC
TGCAATCCAGAGAAGATCCTAATCAGAGATCAAGTACAAAGGTGGTACAACATCTTGGCCCTGCAACTGATTTTTATAAGAAACTTGCAT
TAGATTGCTCGGGACAGCAAACTGCAGTGGATTTGTTCCTTTTAAGTTCACAGTATTCTGATCTTGCTTCTCTAGCTTGCATGTCCAAGT
ATTCTGCAGGGTGCATCTATTATTATCCATCATTCCACTATACTCACAATCCTTCACAAGCAGAAAAGTTACAAAAAGACCTAAAACGGT
ATCTCACAAGAAAAATTGGGTTTGAAGCTGTTATGAGAATAAGGTGTACTAAAGGTCTTTCAATGCACACTTTTCACGGTAACTTCTTTG
TCCGTTCTACTGATTTGTTATCCCTTGCCAACATCAATCCTGATGCTGGATTTGCGGTGCAGTTGTCAATTGAAGAAAGTTTAACAGATA
CTTCCTTAGTATGTTTTCAAACAGCCCTATTATATACATCAAGCAAAGGTGAGCGGAGAATTAGAGTACATACACTTTGTTTGCCAGTGG
TAAGTTCACTAGCAGATGTATATGCGGGAGTGGATGTACAAGCTGCCATCTGCCTTCTGGCAAACATGGCTGTGGATCGGTCCGTTTCAT
CAAGTCTGTCAGATGCAAGAGATGCCTTAGTGAATGCTGTAGTGGACTCATTGTCTGCATATGGCTCAACTGTCTCAAATTTACAGCACT
CTGCATTGATGGCGCCCAGCTCCCTCAAGTTGTTTCCTCTCTATGTTTTGGCCCTTCTCAAACAGAAAGCATTTAGAACGGGTACAAGCA
CACGGCTGGATGATCGTGTATATGCCATGTGTCAGATAAAGTCTCAGCCACTTGTTCATCTAATGAAAATGATTCATCCCAACTTATACA
GGATAGACAGATTGACAGATGAGGGTGCAGTACATGTTAATGACAGGATTGTACCACAGCCACCTCTTCAAAAATTGTCTGCAGAGAAGC
TGACAAGAGAAGGTGCTTTCCTTATGGACTGTGGCTCTGTTTTTTACATTTGGGTTGGGAAAGGCTGTGACAATAACTTCATAGAGGATG
TGCTTGGATATACTAATTTTGCATCAATACCACAGAAAATGACACATCTTCCAGAGCTAGATACACTTTCATCAGAAAGAGCCAGATCCT
TCATAACTTGGCTTAGAGACAGCAGACCATTAAGTCCAATCCTTCACATAGTAAAAGATGAGAGTCCTGCCAAAGCAGAATTTTTTCAGC
ATTTGATTGAAGACCGGACAGAGGCTGCATTTTCTTACTATGAATTTTTGCTTCATGTTCAGCAGCAGATTTGTAAGTGAAGTAGAATAA

>69653_69653_6_PSMD12-SEC24B_PSMD12_chr17_65362528_ENST00000357146_SEC24B_chr4_110427487_ENST00000504968_length(amino acids)=807AA_BP=36
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNLNADLK
KLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFMY
NPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYN
LQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAG
LLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDLK
RYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLP
VVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGT
STRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMD12-SEC24B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMD12-SEC24B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMD12-SEC24B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource