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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMD1-DNER (FusionGDB2 ID:69672)

Fusion Gene Summary for PSMD1-DNER

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD1-DNER
Fusion gene ID: 69672
HgeneTgene
Gene symbol

PSMD1

DNER

Gene ID

5707

92737

Gene nameproteasome 26S subunit, non-ATPase 1delta/notch like EGF repeat containing
SynonymsP112|Rpn2|S1UNQ26|bet
Cytomap

2q37.1

2q36.3

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 126S proteasome regulatory subunit RPN226S proteasome regulatory subunit S126S proteasome subunit p112proteasome (prosome, macropain) 26S subunit, non-ATPase, 1delta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembrane
Modification date2020031320200313
UniProtAcc.

Q8NFT8

Ensembl transtripts involved in fusion geneENST00000308696, ENST00000373635, 
ENST00000409643, ENST00000488354, 
ENST00000482831, ENST00000341772, 
Fusion gene scores* DoF score12 X 11 X 10=13205 X 3 X 4=60
# samples 197
** MAII scorelog2(19/1320*10)=-2.79646660591487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMD1 [Title/Abstract] AND DNER [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMD1(231945028)-DNER(230377652), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PSMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNER (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1830-01APSMD1chr2

231945028

-DNERchr2

230377652

-
ChimerDB4GBMTCGA-27-1830-01APSMD1chr2

231945028

+DNERchr2

230377652

-


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Fusion Gene ORF analysis for PSMD1-DNER

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308696ENST00000482831PSMD1chr2

231945028

+DNERchr2

230377652

-
5CDS-intronENST00000373635ENST00000482831PSMD1chr2

231945028

+DNERchr2

230377652

-
5CDS-intronENST00000409643ENST00000482831PSMD1chr2

231945028

+DNERchr2

230377652

-
In-frameENST00000308696ENST00000341772PSMD1chr2

231945028

+DNERchr2

230377652

-
In-frameENST00000373635ENST00000341772PSMD1chr2

231945028

+DNERchr2

230377652

-
In-frameENST00000409643ENST00000341772PSMD1chr2

231945028

+DNERchr2

230377652

-
intron-3CDSENST00000488354ENST00000341772PSMD1chr2

231945028

+DNERchr2

230377652

-
intron-intronENST00000488354ENST00000482831PSMD1chr2

231945028

+DNERchr2

230377652

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373635PSMD1chr2231945028+ENST00000341772DNERchr2230377652-37071575992795898
ENST00000308696PSMD1chr2231945028+ENST00000341772DNERchr2230377652-37071575992795898
ENST00000409643PSMD1chr2231945028+ENST00000341772DNERchr2230377652-36771545692765898

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373635ENST00000341772PSMD1chr2231945028+DNERchr2230377652-0.00032190.99967813
ENST00000308696ENST00000341772PSMD1chr2231945028+DNERchr2230377652-0.00032190.99967813
ENST00000409643ENST00000341772PSMD1chr2231945028+DNERchr2230377652-0.0003177970.9996822

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Fusion Genomic Features for PSMD1-DNER


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSMD1-DNER


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:231945028/chr2:230377652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNER

Q8NFT8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225403_436471992.3333333333334RepeatNote=PC 1
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225441_474471992.3333333333334RepeatNote=PC 2
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224403_436471960.3333333333334RepeatNote=PC 1
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224441_474471960.3333333333334RepeatNote=PC 2
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223403_436471923.0RepeatNote=PC 1
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223441_474471923.0RepeatNote=PC 2
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413349_390331738.0DomainEGF-like 4
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413392_428331738.0DomainEGF-like 5
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413430_466331738.0DomainEGF-like 6
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413468_503331738.0DomainEGF-like 7
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413505_541331738.0DomainEGF-like 8%3B calcium-binding
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413543_579331738.0DomainEGF-like 9
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413546_568331738.0DomainNote=Follistatin-like
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413581_617331738.0DomainEGF-like 10%3B calcium-binding
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413662_737331738.0Topological domainCytoplasmic
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413641_661331738.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225936_943471992.3333333333334Compositional biasNote=Poly-Glu
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224936_943471960.3333333333334Compositional biasNote=Poly-Glu
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223936_943471923.0Compositional biasNote=Poly-Glu
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225476_510471992.3333333333334RepeatNote=PC 3
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225511_545471992.3333333333334RepeatNote=PC 4
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225547_580471992.3333333333334RepeatNote=PC 5
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225581_616471992.3333333333334RepeatNote=PC 6
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225617_649471992.3333333333334RepeatNote=PC 7
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225651_685471992.3333333333334RepeatNote=PC 8
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225686_726471992.3333333333334RepeatNote=PC 9
HgenePSMD1chr2:231945028chr2:230377652ENST00000308696+1225729_761471992.3333333333334RepeatNote=PC 10
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224476_510471960.3333333333334RepeatNote=PC 3
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224511_545471960.3333333333334RepeatNote=PC 4
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224547_580471960.3333333333334RepeatNote=PC 5
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224581_616471960.3333333333334RepeatNote=PC 6
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224617_649471960.3333333333334RepeatNote=PC 7
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224651_685471960.3333333333334RepeatNote=PC 8
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224686_726471960.3333333333334RepeatNote=PC 9
HgenePSMD1chr2:231945028chr2:230377652ENST00000373635+1224729_761471960.3333333333334RepeatNote=PC 10
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223476_510471923.0RepeatNote=PC 3
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223511_545471923.0RepeatNote=PC 4
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223547_580471923.0RepeatNote=PC 5
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223581_616471923.0RepeatNote=PC 6
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223617_649471923.0RepeatNote=PC 7
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223651_685471923.0RepeatNote=PC 8
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223686_726471923.0RepeatNote=PC 9
HgenePSMD1chr2:231945028chr2:230377652ENST00000409643+1223729_761471923.0RepeatNote=PC 10
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413309_348331738.0DomainEGF-like 3
TgeneDNERchr2:231945028chr2:230377652ENST0000034177241344_92331738.0DomainEGF-like 1
TgeneDNERchr2:231945028chr2:230377652ENST0000034177241394_133331738.0DomainEGF-like 2
TgeneDNERchr2:231945028chr2:230377652ENST0000034177241335_640331738.0Topological domainExtracellular


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Fusion Gene Sequence for PSMD1-DNER


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69672_69672_1_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000308696_DNER_chr2_230377652_ENST00000341772_length(transcript)=3707nt_BP=1575nt
GGGGTCCTGGCGAGAAGCGAGCCGGCGGCCTGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCG
GCCCCTGAGCTGACAGATACACTGCGCAGCTGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCT
GGAATTATTTCTCTTCTGGATGAAGATGAACCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCA
GAAATTTCCGAGTCCGTAGACAAAATAGAGGTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAA
GTATTTTATCACCTGGGGGCTTTTGAGGAGTCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATAT
GTGGAAACTATTATAGCAAAATGCATTGATCACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATT
GACCAGAGATTGGAAGGCATCGTAAATAAAATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAG
ACACGAAGACTGGACGTCTTTGAAAAGACCATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCT
TTAATGCAGAATAAACAGTTTCGGAATAAAGTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTT
TGTCAGTGCTTAATTTTCTTAGATGATCCTCAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATAT
CAGATTTGTTTTGATTTGTATGAAAGTGCTAGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCT
TCTGTGCCTGGATCCACTAATACGGGTACTGTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCA
TTTGTAGGAAAGACACCAGAAGCCAGTCCAGAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAG
TTACATCTGCAGTTCTTAATACGAAACAATAATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCAT
ACTGCAACCGTTATAGCAAACTCTTTTATGCACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCC
ACTAACTGGGCAAAATTTACTGCTACAGCCAGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATAC
CTTCCCAAGGATACTTCTCCAGGATCAGCCTATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGAT
ATAATTGACTATCTGCTTAATCAGCTTAAGAACGCCAGCAATGATGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGGTACTTTC
TGTGAAGAATACGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAGCAATTTC
ACCTGTGTTTGCCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGGAGCAACA
TGCATTTCCAGTCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTGCGCCTCG
TCTCCGTGCCAGAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGACCTGTGCC
CAGCTTATTGACTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGATCCAGGT
TACCATGGCCTCTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGTTAATGGC
TATGAGTGTGTGTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAACGGAGCC
ACCTGTGACAGCGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGAATGTGAC
AGTAACCCCTGCCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGCAAACTGT
GAGATCCACCTCCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGGAGCCCTC
TGCGTGGCCTTCATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAGGCCAGCC
TATGAGGAGTTCTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAAGAAATCC
CGGCCTGCAATGTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAACTAAAGAT
TTGTAATCTTTTTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAGAAATTTA
AAATGCTAGCTGCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAAAACAAAA
TTTGTGAAACCTATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTGTAGACAC
TATCACGAGACCCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCCGGCTTTC
TGAGTAGAGTTAGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGTTCGTTTT
GTGGAAAAGAAACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACTTATTTCT
GCACTGTTTTGTTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAAAAACATA
CGTAACGAAAAGGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTGAGTAAAT
TAAATTTACATTTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCATAGTGCAG
CTTTATTTATCTCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCTTGCTAATTTCCAACCATATTGAATAAA

>69672_69672_1_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000308696_DNER_chr2_230377652_ENST00000341772_length(amino acids)=898AA_BP=492
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCV
CLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI
DFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD
SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVA

--------------------------------------------------------------
>69672_69672_2_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000373635_DNER_chr2_230377652_ENST00000341772_length(transcript)=3707nt_BP=1575nt
GGGGTCCTGGCGAGAAGCGAGCCGGCGGCCTGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCG
GCCCCTGAGCTGACAGATACACTGCGCAGCTGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCT
GGAATTATTTCTCTTCTGGATGAAGATGAACCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCA
GAAATTTCCGAGTCCGTAGACAAAATAGAGGTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAA
GTATTTTATCACCTGGGGGCTTTTGAGGAGTCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATAT
GTGGAAACTATTATAGCAAAATGCATTGATCACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATT
GACCAGAGATTGGAAGGCATCGTAAATAAAATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAG
ACACGAAGACTGGACGTCTTTGAAAAGACCATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCT
TTAATGCAGAATAAACAGTTTCGGAATAAAGTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTT
TGTCAGTGCTTAATTTTCTTAGATGATCCTCAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATAT
CAGATTTGTTTTGATTTGTATGAAAGTGCTAGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCT
TCTGTGCCTGGATCCACTAATACGGGTACTGTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCA
TTTGTAGGAAAGACACCAGAAGCCAGTCCAGAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAG
TTACATCTGCAGTTCTTAATACGAAACAATAATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCAT
ACTGCAACCGTTATAGCAAACTCTTTTATGCACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCC
ACTAACTGGGCAAAATTTACTGCTACAGCCAGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATAC
CTTCCCAAGGATACTTCTCCAGGATCAGCCTATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGAT
ATAATTGACTATCTGCTTAATCAGCTTAAGAACGCCAGCAATGATGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGGTACTTTC
TGTGAAGAATACGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAGCAATTTC
ACCTGTGTTTGCCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGGAGCAACA
TGCATTTCCAGTCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTGCGCCTCG
TCTCCGTGCCAGAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGACCTGTGCC
CAGCTTATTGACTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGATCCAGGT
TACCATGGCCTCTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGTTAATGGC
TATGAGTGTGTGTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAACGGAGCC
ACCTGTGACAGCGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGAATGTGAC
AGTAACCCCTGCCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGCAAACTGT
GAGATCCACCTCCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGGAGCCCTC
TGCGTGGCCTTCATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAGGCCAGCC
TATGAGGAGTTCTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAAGAAATCC
CGGCCTGCAATGTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAACTAAAGAT
TTGTAATCTTTTTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAGAAATTTA
AAATGCTAGCTGCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAAAACAAAA
TTTGTGAAACCTATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTGTAGACAC
TATCACGAGACCCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCCGGCTTTC
TGAGTAGAGTTAGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGTTCGTTTT
GTGGAAAAGAAACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACTTATTTCT
GCACTGTTTTGTTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAAAAACATA
CGTAACGAAAAGGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTGAGTAAAT
TAAATTTACATTTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCATAGTGCAG
CTTTATTTATCTCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCTTGCTAATTTCCAACCATATTGAATAAA

>69672_69672_2_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000373635_DNER_chr2_230377652_ENST00000341772_length(amino acids)=898AA_BP=492
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCV
CLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI
DFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD
SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVA

--------------------------------------------------------------
>69672_69672_3_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000409643_DNER_chr2_230377652_ENST00000341772_length(transcript)=3677nt_BP=1545nt
TGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCGGCCCCTGAGCTGACAGATACACTGCGCAGC
TGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCTGGAATTATTTCTCTTCTGGATGAAGATGAA
CCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCAGAAATTTCCGAGTCCGTAGACAAAATAGAG
GTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAAGTATTTTATCACCTGGGGGCTTTTGAGGAG
TCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATATGTGGAAACTATTATAGCAAAATGCATTGAT
CACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATTGACCAGAGATTGGAAGGCATCGTAAATAAA
ATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAGACACGAAGACTGGACGTCTTTGAAAAGACC
ATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCTTTAATGCAGAATAAACAGTTTCGGAATAAA
GTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTTTGTCAGTGCTTAATTTTCTTAGATGATCCT
CAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATATCAGATTTGTTTTGATTTGTATGAAAGTGCT
AGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCTTCTGTGCCTGGATCCACTAATACGGGTACT
GTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCATTTGTAGGAAAGACACCAGAAGCCAGTCCA
GAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAGTTACATCTGCAGTTCTTAATACGAAACAAT
AATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCATACTGCAACCGTTATAGCAAACTCTTTTATG
CACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCCACTAACTGGGCAAAATTTACTGCTACAGCC
AGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATACCTTCCCAAGGATACTTCTCCAGGATCAGCC
TATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGATATAATTGACTATCTGCTTAATCAGCTTAAG
AACGCCAGCAATGATGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGGTACTTTCTGTGAAGAATACGATGCTTGCCAGAGGAAA
CCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAGCAATTTCACCTGTGTTTGCCTTCCTGGTTATACTGGA
GAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGGAGCAACATGCATTTCCAGTCTCAGTGGATTCACCTGC
CAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTGCGCCTCGTCTCCGTGCCAGAACAACGGCACCTGCTAT
GTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGACCTGTGCCCAGCTTATTGACTTCTGTGCCCTCAGCCCC
TGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGATCCAGGTTACCATGGCCTCTACTGTGAGGAGGAATAT
AATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGTTAATGGCTATGAGTGTGTGTGCCTGGCAGAATACAAA
GGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAACGGAGCCACCTGTGACAGCGACGGCCTGAATGGCACG
TGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGAATGTGACAGTAACCCCTGCCACCATGGTGGGAGCTGC
CTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGCAAACTGTGAGATCCACCTCCAATGGAAGTCCGGGCAC
ATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGGAGCCCTCTGCGTGGCCTTCATCCTTATGCTGATCATC
CTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAGGCCAGCCTATGAGGAGTTCTACAACTGCCGCAGCATC
GACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAAGAAATCCCGGCCTGCAATGTATGATGTGAGCCCCATC
GCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAACTAAAGATTTGTAATCTTTTTTTGGATTATTTTTCAAA
AAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAGAAATTTAAAATGCTAGCTGCTCAAGAGTTTTCAGTAG
AATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAAAACAAAATTTGTGAAACCTATAGACGATGTTTTAATG
TACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTGTAGACACTATCACGAGACCCAGATTAATTTCTGTGGT
TGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCCGGCTTTCTGAGTAGAGTTAGGAAAACCACGTAACGTA
GCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGTTCGTTTTGTGGAAAAGAAACTAGTTAAATTTACTATT
CCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACTTATTTCTGCACTGTTTTGTTGAACTTTGTGGAAACAT
TCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAAAAACATACGTAACGAAAAGGCCTAGCGAGGCAAATTC
TGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTGAGTAAATTAAATTTACATTTGAGTTGTTTGTTGCTAA
GAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCATAGTGCAGCTTTATTTATCTCCAGGATGTTTTTGTGGC

>69672_69672_3_PSMD1-DNER_PSMD1_chr2_231945028_ENST00000409643_DNER_chr2_230377652_ENST00000341772_length(amino acids)=898AA_BP=492
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCV
CLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI
DFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD
SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMD1-DNER


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDNERchr2:231945028chr2:230377652ENST00000341772413677_680331.0738.0AP1G1 and somatodendritic targeting


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDNERchr2:231945028chr2:230377652ENST0000034177241344_133331.0738.0NOTCH1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMD1-DNER


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMD1-DNER


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource