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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASAP1-PTK2 (FusionGDB2 ID:6968)

Fusion Gene Summary for ASAP1-PTK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP1-PTK2
Fusion gene ID: 6968
HgeneTgene
Gene symbol

ASAP1

PTK2

Gene ID

50807

5747

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 1protein tyrosine kinase 2
SynonymsAMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14PFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Cytomap

8q24.21-q24.22

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosylfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
Modification date2020032720200327
UniProtAcc

Q9ULH1

.
Ensembl transtripts involved in fusion geneENST00000357668, ENST00000518721, 
ENST00000520625, 		ENST00000517712, 
ENST00000519635, ENST00000519881, 
ENST00000520151, ENST00000520892, 
ENST00000522950, ENST00000340930, 
ENST00000395218, ENST00000430260, 
ENST00000517887, ENST00000519419, 
ENST00000519465, ENST00000521059, 
ENST00000522684, ENST00000535192, 
ENST00000538769, 
Fusion gene scores* DoF score25 X 17 X 13=552519 X 20 X 13=4940
# samples 2829
** MAII scorelog2(28/5525*10)=-4.30247573222119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/4940*10)=-4.09038623645711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAP1 [Title/Abstract] AND PTK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASAP1(131370263)-PTK2(141685598), # samples:1
Anticipated loss of major functional domain due to fusion event.ASAP1-PTK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASAP1-PTK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ASAP1-PTK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

TgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

TgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

TgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

TgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

TgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

TgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

TgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

TgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

TgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across ASAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IP-7968-11AASAP1chr8

131370263

-PTK2chr8

141685598

-


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Fusion Gene ORF analysis for ASAP1-PTK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357668ENST00000517712ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000357668ENST00000519635ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000357668ENST00000519881ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000357668ENST00000520151ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000357668ENST00000520892ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000357668ENST00000522950ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000517712ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000519635ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000519881ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000520151ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000520892ASAP1chr8

131370263

-PTK2chr8

141685598

-
5CDS-intronENST00000518721ENST00000522950ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000340930ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000395218ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000430260ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000517887ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000519419ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000519465ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000521059ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000522684ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000535192ASAP1chr8

131370263

-PTK2chr8

141685598

-
Frame-shiftENST00000518721ENST00000538769ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000340930ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000395218ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000430260ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000517887ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000519419ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000519465ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000521059ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000522684ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000535192ASAP1chr8

131370263

-PTK2chr8

141685598

-
In-frameENST00000357668ENST00000538769ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000340930ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000395218ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000430260ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000517887ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000519419ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000519465ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000521059ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000522684ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000535192ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-3CDSENST00000520625ENST00000538769ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000517712ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000519635ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000519881ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000520151ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000520892ASAP1chr8

131370263

-PTK2chr8

141685598

-
intron-intronENST00000520625ENST00000522950ASAP1chr8

131370263

-PTK2chr8

141685598

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357668ASAP1chr8131370263-ENST00000522684PTK2chr8141685598-237721428810260
ENST00000357668ASAP1chr8131370263-ENST00000535192PTK2chr8141685598-188621428810260
ENST00000357668ASAP1chr8131370263-ENST00000519465PTK2chr8141685598-187521428810260
ENST00000357668ASAP1chr8131370263-ENST00000517887PTK2chr8141685598-187521428810260
ENST00000357668ASAP1chr8131370263-ENST00000521059PTK2chr8141685598-187521428810260
ENST00000357668ASAP1chr8131370263-ENST00000395218PTK2chr8141685598-191421428849273
ENST00000357668ASAP1chr8131370263-ENST00000538769PTK2chr8141685598-187221428810260
ENST00000357668ASAP1chr8131370263-ENST00000340930PTK2chr8141685598-191121428849273
ENST00000357668ASAP1chr8131370263-ENST00000519419PTK2chr8141685598-164721428810260
ENST00000357668ASAP1chr8131370263-ENST00000430260PTK2chr8141685598-120421428810260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357668ENST00000522684ASAP1chr8131370263-PTK2chr8141685598-0.002124350.9978757
ENST00000357668ENST00000535192ASAP1chr8131370263-PTK2chr8141685598-0.0021232960.99787676
ENST00000357668ENST00000519465ASAP1chr8131370263-PTK2chr8141685598-0.0022503370.9977496
ENST00000357668ENST00000517887ASAP1chr8131370263-PTK2chr8141685598-0.0022503370.9977496
ENST00000357668ENST00000521059ASAP1chr8131370263-PTK2chr8141685598-0.0022503370.9977496
ENST00000357668ENST00000395218ASAP1chr8131370263-PTK2chr8141685598-0.0008936350.99910635
ENST00000357668ENST00000538769ASAP1chr8131370263-PTK2chr8141685598-0.0023112280.9976888
ENST00000357668ENST00000340930ASAP1chr8131370263-PTK2chr8141685598-0.0009379690.999062
ENST00000357668ENST00000519419ASAP1chr8131370263-PTK2chr8141685598-0.0046697420.99533033
ENST00000357668ENST00000430260ASAP1chr8131370263-PTK2chr8141685598-0.0089132960.99108666

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Fusion Genomic Features for ASAP1-PTK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASAP1-PTK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:131370263/chr8:141685598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAP1

Q9ULH1

.
FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633863_9138541066.0Compositional biasNote=Pro-rich
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632863_9138541053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632863_9138541053.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229783_993621130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330783_993621130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-2291067_1129621130.0DomainSH3
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229324_416621130.0DomainPH
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229439_560621130.0DomainArf-GAP
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-3301067_1129621130.0DomainSH3
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330324_416621130.0DomainPH
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330439_560621130.0DomainArf-GAP
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229600_632621130.0RepeatNote=ANK 1
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229636_665621130.0RepeatNote=ANK 2
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330600_632621130.0RepeatNote=ANK 1
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330636_665621130.0RepeatNote=ANK 2
HgeneASAP1chr8:131370263chr8:141685598ENST00000357668-229454_477621130.0Zinc fingerC4-type
HgeneASAP1chr8:131370263chr8:141685598ENST00000518721-330454_477621130.0Zinc fingerC4-type
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633712_7338541066.0Compositional biasNote=Pro-rich
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632712_7338541053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632712_7338541053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:131370263chr8:141685598ENST00000340930263335_3558541066.0DomainFERM
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633422_6808541066.0DomainProtein kinase
TgenePTK2chr8:131370263chr8:141685598ENST00000521059263235_3558541053.0DomainFERM
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632422_6808541053.0DomainProtein kinase
TgenePTK2chr8:131370263chr8:141685598ENST00000522684263235_3558541053.0DomainFERM
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632422_6808541053.0DomainProtein kinase
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633428_4348541066.0Nucleotide bindingATP
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633500_5028541066.0Nucleotide bindingATP
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632428_4348541053.0Nucleotide bindingATP
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632500_5028541053.0Nucleotide bindingATP
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632428_4348541053.0Nucleotide bindingATP
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632500_5028541053.0Nucleotide bindingATP


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Fusion Gene Sequence for ASAP1-PTK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6968_6968_1_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000340930_length(transcript)=1911nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAA
TTGGGCGGAAAGAAATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAG
CCCTGCTGACAGCTACAACGAGGGTGTCAAGCCATGGAGGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTC
GAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTA
TGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCA
CCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGAC
CAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCA
AGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAG
CCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAA
TCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATC
CAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCT
AAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGG
AAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAAT
ATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCT
GCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATA
ATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTC
CAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAAC
CCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTA
ATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACC

>6968_6968_1_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000340930_length(amino acids)=273AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPGKEEKNWAERNPAAP
PKKPPRPGAPGHLGSLASLSSPADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGL
ALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQT

--------------------------------------------------------------
>6968_6968_2_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000395218_length(transcript)=1914nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAA
TTGGGCGGAAAGAAATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAG
CCCTGCTGACAGCTACAACGAGGGTGTCAAGCCAAATCAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTC
GAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTA
TGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCA
CCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGAC
CAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCA
AGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAG
CCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAA
TCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATC
CAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCT
AAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGG
AAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAAT
ATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCT
GCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATA
ATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTC
CAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAAC
CCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTA
ATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACC

>6968_6968_2_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000395218_length(amino acids)=273AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPGKEEKNWAERNPAAP
PKKPPRPGAPGHLGSLASLSSPADSYNEGVKPNQLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGL
ALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQT

--------------------------------------------------------------
>6968_6968_3_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000430260_length(transcript)=1204nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA

>6968_6968_3_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000430260_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_4_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000517887_length(transcript)=1875nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG

>6968_6968_4_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000517887_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_5_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000519419_length(transcript)=1647nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA

>6968_6968_5_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000519419_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_6_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000519465_length(transcript)=1875nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG

>6968_6968_6_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000519465_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_7_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000521059_length(transcript)=1875nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG

>6968_6968_7_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000521059_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_8_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000522684_length(transcript)=2377nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG
ATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTCTTGTTGTAATA
TCCTTTCTTTTGGTTCTGTTTCTTCAGATGGCTTTTCAGGTGACTTGTCAGATAAGATAACATACAAGAGAGTTCCCAATAATTATCAGG
AAGCCTCTCACTAATTAGTTTCTTTTTTTTTATTTAATCTTCTAAACAAGTCAAGGATGTTACCACAGAAGGGTAGCGTGGCGTAAGTTA
ACCTTTTCATTCCATCGTCACCTATTAAATGCAGAGCTCAGGATGGAAGTAGCAATGGTCTTCAATGAAAGAACCTTCCCCTGCGCAGGG
TCTCACTATTCCGCTAACTCGGACTCAAAGCATAATTCACTTGTCAAGGAAATTGTTAGCATTTCCCAGGCCCACCCTAGTCTTGCTAGA
ATCTCTGTGAGCCACAGAGCAGGGAGCAAATAGAACTGAGATCTCCAGCACTAGGGACTCAGACTCCAAAGGGAGGGATTTGAGTGAATT

>6968_6968_8_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000522684_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

--------------------------------------------------------------
>6968_6968_9_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000535192_length(transcript)=1886nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG

>6968_6968_9_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000535192_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

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>6968_6968_10_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000538769_length(transcript)=1872nt_BP=214nt
GGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGAT
GCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCA
CAACTGCAGGAACACCGTCACGCTGCTGGAGGAGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACC
AAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAA
GCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAA
AGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGAC
ATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGA
CCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGC
TGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTG
AGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAG
TCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTT
CATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTA
AGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAA
CTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAA
TTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATT
TTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCG
GGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAA
GCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAA
AGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAA
AACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGG

>6968_6968_10_ASAP1-PTK2_ASAP1_chr8_131370263_ENST00000357668_PTK2_chr8_141685598_ENST00000538769_length(amino acids)=260AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEIGNQHIYQPVGKPDPAAPPKKPPRPGAP
GHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI

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Fusion Gene PPI Analysis for ASAP1-PTK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTK2chr8:131370263chr8:141685598ENST000003409302633912_1052854.01066.0ARHGEF28
TgenePTK2chr8:131370263chr8:141685598ENST000005210592632912_1052854.01053.0ARHGEF28
TgenePTK2chr8:131370263chr8:141685598ENST000005226842632912_1052854.01053.0ARHGEF28


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASAP1-PTK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASAP1-PTK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource