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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMD3-C11orf80 (FusionGDB2 ID:69689)

Fusion Gene Summary for PSMD3-C11orf80

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD3-C11orf80
Fusion gene ID: 69689
HgeneTgene
Gene symbol

PSMD3

C11orf80

Gene ID

5709

79703

Gene nameproteasome 26S subunit, non-ATPase 3chromosome 11 open reading frame 80
SynonymsP58|RPN3|S3|TSTA2HYDM4|TOP6BL|TOPOVIBL
Cytomap

17q21.1

11q13.2

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2type 2 DNA topoisomerase 6 subunit B-liketype 2 DNA topoisomerase VI subunit B-like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264639, ENST00000541736, 
ENST00000527368, ENST00000346672, 
ENST00000360962, ENST00000525449, 
ENST00000527634, ENST00000532565, 
ENST00000540737, 
Fusion gene scores* DoF score8 X 5 X 7=28019 X 19 X 10=3610
# samples 1224
** MAII scorelog2(12/280*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3610*10)=-3.91089252616601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD3 [Title/Abstract] AND C11orf80 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMD3(38137443)-C11orf80(66526514), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PSMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C11orf80 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01APSMD3chr17

38137443

+C11orf80chr11

66523824

+
ChimerDB4BRCATCGA-A1-A0SN-01APSMD3chr17

38137443

+C11orf80chr11

66526514

+
ChimerDB4BRCATCGA-A1-A0SNPSMD3chr17

38137443

+C11orf80chr11

66526513

+


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Fusion Gene ORF analysis for PSMD3-C11orf80

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264639ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66526514

+
5CDS-3UTRENST00000264639ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66526513

+
5CDS-5UTRENST00000264639ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-5UTRENST00000264639ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-5UTRENST00000264639ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-5UTRENST00000264639ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66526514

+
5CDS-5UTRENST00000264639ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66526513

+
5CDS-5UTRENST00000264639ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66526514

+
5CDS-5UTRENST00000264639ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66526513

+
5CDS-5UTRENST00000264639ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-5UTRENST00000264639ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66526514

+
5CDS-5UTRENST00000264639ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66526513

+
5CDS-5UTRENST00000264639ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66526514

+
5CDS-5UTRENST00000264639ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66526513

+
5CDS-intronENST00000264639ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-intronENST00000264639ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66523824

+
5CDS-intronENST00000264639ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66523824

+
In-frameENST00000264639ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66526514

+
In-frameENST00000264639ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66526513

+
In-frameENST00000264639ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66526514

+
In-frameENST00000264639ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-3CDSENST00000541736ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-3CDSENST00000541736ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-3CDSENST00000541736ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-3CDSENST00000541736ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-3UTRENST00000541736ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-3UTRENST00000541736ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-5UTRENST00000541736ENST00000346672PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-5UTRENST00000541736ENST00000360962PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-5UTRENST00000541736ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-5UTRENST00000541736ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-5UTRENST00000541736ENST00000525449PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-5UTRENST00000541736ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-5UTRENST00000541736ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-5UTRENST00000541736ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-5UTRENST00000541736ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-5UTRENST00000541736ENST00000532565PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-5UTRENST00000541736ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66526514

+
intron-5UTRENST00000541736ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66526513

+
intron-intronENST00000541736ENST00000527368PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-intronENST00000541736ENST00000527634PSMD3chr17

38137443

+C11orf80chr11

66523824

+
intron-intronENST00000541736ENST00000540737PSMD3chr17

38137443

+C11orf80chr11

66523824

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264639PSMD3chr1738137443+ENST00000346672C11orf80chr1166526514+19453941741850558
ENST00000264639PSMD3chr1738137443+ENST00000360962C11orf80chr1166526514+22413941741958594
ENST00000264639PSMD3chr1738137443+ENST00000346672C11orf80chr1166526513+19453941741850558
ENST00000264639PSMD3chr1738137443+ENST00000360962C11orf80chr1166526513+22413941741958594

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264639ENST00000346672PSMD3chr1738137443+C11orf80chr1166526514+0.0152480980.9847519
ENST00000264639ENST00000360962PSMD3chr1738137443+C11orf80chr1166526514+0.0149023670.98509765
ENST00000264639ENST00000346672PSMD3chr1738137443+C11orf80chr1166526513+0.0152480980.9847519
ENST00000264639ENST00000360962PSMD3chr1738137443+C11orf80chr1166526513+0.0149023670.98509765

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Fusion Genomic Features for PSMD3-C11orf80


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMD3chr1738137443+C11orf80chr1166526513+2.35E-121
PSMD3chr1738137443+C11orf80chr1166526513+2.35E-121
PSMD3chr1738137443+C11orf80chr1166523823+3.25E-111
PSMD3chr1738137443+C11orf80chr1166526513+2.35E-121
PSMD3chr1738137443+C11orf80chr1166526513+2.35E-121
PSMD3chr1738137443+C11orf80chr1166523823+3.25E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSMD3-C11orf80


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38137443/chr11:66526514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD3chr17:38137443chr11:66526513ENST00000264639+11226_3273535.0Compositional biasNote=Poly-Pro
HgenePSMD3chr17:38137443chr11:66526514ENST00000264639+11226_3273535.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD3chr17:38137443chr11:66526513ENST00000264639+112286_46573535.0DomainPCI
HgenePSMD3chr17:38137443chr11:66526514ENST00000264639+112286_46573535.0DomainPCI


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Fusion Gene Sequence for PSMD3-C11orf80


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69689_69689_1_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526513_ENST00000346672_length(transcript)=1945nt_BP=394nt
GGCGTTTCCCAGAAGGCCCAGCGCCGGGAAGGGGTTTGCAGCTGCTCCGTCATCGTGCGGCCCGACGCTATCTCGCGCTCGTGTGCAGGC
CCGGCTCGGCTCCTGGTCCCCGGTGCGAGGGTTAACGCGAGGCCCCGGCCTCGGTCCCCGGACTAGGCCGTGACCCCGGGTGCCATGAAG
CAGGAGGGCTCGGCGCGGCGCCGCGGCGCGGACAAGGCGAAACCGCCGCCCGGCGGAGGAGAACAAGAACCCCCACCGCCGCCGGCCCCC
CAGGATGTGGAGATGAAAGAGGAGGCAGCGACGGGTGGCGGGTCGACGGGGGAGGCAGACGGCAAGACGGCGGCGGCAGCGGCTGAGCAC
TCCCAGCGAGAGCTGGACACAGTCACCTTGGAGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAA
ATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCC
TTCCAGATGATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATG
GTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTG
AACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGTAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGA
ATTCACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCA
GCAGCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGT
CTGCCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTG
TGTATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAG
TCTCAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATC
TGGGGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTG
GACAAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATC
ACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCACTGAGGAC
GCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCCGCATAGAG
GAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCCTCACTCCT
AGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGCTGTGGCTG
CAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGATCCGGAGGC

>69689_69689_1_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526513_ENST00000346672_length(amino acids)=558AA_BP=71
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEVASAGSLFGGMVLKKFL
KEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEP
TLNLGNGIALLVDSQHYVSRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGP
LGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQM
EIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGT
EDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVL

--------------------------------------------------------------
>69689_69689_2_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526513_ENST00000360962_length(transcript)=2241nt_BP=394nt
GGCGTTTCCCAGAAGGCCCAGCGCCGGGAAGGGGTTTGCAGCTGCTCCGTCATCGTGCGGCCCGACGCTATCTCGCGCTCGTGTGCAGGC
CCGGCTCGGCTCCTGGTCCCCGGTGCGAGGGTTAACGCGAGGCCCCGGCCTCGGTCCCCGGACTAGGCCGTGACCCCGGGTGCCATGAAG
CAGGAGGGCTCGGCGCGGCGCCGCGGCGCGGACAAGGCGAAACCGCCGCCCGGCGGAGGAGAACAAGAACCCCCACCGCCGCCGGCCCCC
CAGGATGTGGAGATGAAAGAGGAGGCAGCGACGGGTGGCGGGTCGACGGGGGAGGCAGACGGCAAGACGGCGGCGGCAGCGGCTGAGCAC
TCCCAGCGAGAGCTGGACACAGTCACCTTGGAGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAA
ATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCC
TTCCAGATGATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATG
GTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTG
AACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGAATT
CACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCAGCA
GCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGTCTG
CCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTGTGT
ATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCT
CAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGG
GGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGAC
AAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATT
CTGACTGGAAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCAC
AAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCA
GCCCAGGGCACTGAGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGG
GGCAGCCCCCGCATAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACC
GCGGCCCCCCTCACTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTG
GAGGACGTGCTGTGGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGC
GCCCACCGATCCGGAGGCTGCGGGCAGCCGTTATCCCGTGGTTTAATAAAGCTGCCGCGCGCTCACCAAGTCCTCTTCCGCGTCTGCTTC
CGCGTCGGGCCCGGGCGGGGCGGGGCGGGGCGTGGAGCCGCGCCGCGGCCTGACGTCACCCACACCTCCCTGGGACTGCGTCACTGGTGC

>69689_69689_2_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526513_ENST00000360962_length(amino acids)=594AA_BP=71
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEVASAGSLFGGMVLKKFL
KEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEP
TLNLGNGIALLVDSQHYVRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPL
GLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQME
IWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTK
LHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPE

--------------------------------------------------------------
>69689_69689_3_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526514_ENST00000346672_length(transcript)=1945nt_BP=394nt
GGCGTTTCCCAGAAGGCCCAGCGCCGGGAAGGGGTTTGCAGCTGCTCCGTCATCGTGCGGCCCGACGCTATCTCGCGCTCGTGTGCAGGC
CCGGCTCGGCTCCTGGTCCCCGGTGCGAGGGTTAACGCGAGGCCCCGGCCTCGGTCCCCGGACTAGGCCGTGACCCCGGGTGCCATGAAG
CAGGAGGGCTCGGCGCGGCGCCGCGGCGCGGACAAGGCGAAACCGCCGCCCGGCGGAGGAGAACAAGAACCCCCACCGCCGCCGGCCCCC
CAGGATGTGGAGATGAAAGAGGAGGCAGCGACGGGTGGCGGGTCGACGGGGGAGGCAGACGGCAAGACGGCGGCGGCAGCGGCTGAGCAC
TCCCAGCGAGAGCTGGACACAGTCACCTTGGAGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAA
ATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCC
TTCCAGATGATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATG
GTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTG
AACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGTAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGA
ATTCACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCA
GCAGCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGT
CTGCCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTG
TGTATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAG
TCTCAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATC
TGGGGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTG
GACAAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATC
ACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCACTGAGGAC
GCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCCGCATAGAG
GAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCCTCACTCCT
AGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGCTGTGGCTG
CAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGATCCGGAGGC

>69689_69689_3_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526514_ENST00000346672_length(amino acids)=558AA_BP=71
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEVASAGSLFGGMVLKKFL
KEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEP
TLNLGNGIALLVDSQHYVSRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGP
LGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQM
EIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGT
EDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVL

--------------------------------------------------------------
>69689_69689_4_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526514_ENST00000360962_length(transcript)=2241nt_BP=394nt
GGCGTTTCCCAGAAGGCCCAGCGCCGGGAAGGGGTTTGCAGCTGCTCCGTCATCGTGCGGCCCGACGCTATCTCGCGCTCGTGTGCAGGC
CCGGCTCGGCTCCTGGTCCCCGGTGCGAGGGTTAACGCGAGGCCCCGGCCTCGGTCCCCGGACTAGGCCGTGACCCCGGGTGCCATGAAG
CAGGAGGGCTCGGCGCGGCGCCGCGGCGCGGACAAGGCGAAACCGCCGCCCGGCGGAGGAGAACAAGAACCCCCACCGCCGCCGGCCCCC
CAGGATGTGGAGATGAAAGAGGAGGCAGCGACGGGTGGCGGGTCGACGGGGGAGGCAGACGGCAAGACGGCGGCGGCAGCGGCTGAGCAC
TCCCAGCGAGAGCTGGACACAGTCACCTTGGAGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAA
ATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCC
TTCCAGATGATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATG
GTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTG
AACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGAATT
CACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCAGCA
GCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGTCTG
CCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTGTGT
ATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCT
CAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGG
GGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGAC
AAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATT
CTGACTGGAAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCAC
AAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCA
GCCCAGGGCACTGAGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGG
GGCAGCCCCCGCATAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACC
GCGGCCCCCCTCACTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTG
GAGGACGTGCTGTGGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGC
GCCCACCGATCCGGAGGCTGCGGGCAGCCGTTATCCCGTGGTTTAATAAAGCTGCCGCGCGCTCACCAAGTCCTCTTCCGCGTCTGCTTC
CGCGTCGGGCCCGGGCGGGGCGGGGCGGGGCGTGGAGCCGCGCCGCGGCCTGACGTCACCCACACCTCCCTGGGACTGCGTCACTGGTGC

>69689_69689_4_PSMD3-C11orf80_PSMD3_chr17_38137443_ENST00000264639_C11orf80_chr11_66526514_ENST00000360962_length(amino acids)=594AA_BP=71
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEVASAGSLFGGMVLKKFL
KEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEP
TLNLGNGIALLVDSQHYVRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPL
GLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQME
IWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTK
LHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMD3-C11orf80


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMD3-C11orf80


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMD3-C11orf80


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource