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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PSMD6-PDE3B (FusionGDB2 ID:69716)

Fusion Gene Summary for PSMD6-PDE3B

Fusion gene summary

Fusion gene information	Fusion gene name: PSMD6-PDE3B
	Fusion gene ID: 69716
		Hgene	Tgene
	Gene symbol	PSMD6	PDE3B
	Gene ID	9861	5140
	Gene name	proteasome 26S subunit, non-ATPase 6	phosphodiesterase 3B
	Synonyms	Rpn7\|S10\|SGA-113M\|p42A\|p44S10	HcGIP1\|cGIPDE1
	Cytomap	3p14.1	11p15.2
	Type of gene	protein-coding	protein-coding
	Description	26S proteasome non-ATPase regulatory subunit 6breast cancer-associated protein SGA-113Mphosphonoformate immuno-associated protein 4proteasome (prosome, macropain) 26S subunit, non-ATPase, 6proteasome regulatory particle subunit p44S10	cGMP-inhibited 3',5'-cyclic phosphodiesterase BCGI-PDE BCGIP1cyclic GMP-inhibited phosphodiesterase Bcyclic nucleotide phosphodiesterasephosphodiesterase 3B, cGMP-inhibited
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000295901, ENST00000394431, ENST00000482510, ENST00000492933,	ENST00000534317, ENST00000282096, ENST00000455098,
Fusion gene scores	* DoF score	5 X 5 X 3=75	7 X 7 X 4=196
	# samples	5	7
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PSMD6 [Title/Abstract] AND PDE3B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PSMD6(64004275)-PDE3B(14856616), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PSMD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDE3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-CJ-4876-01A	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+

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Fusion Gene ORF analysis for PSMD6-PDE3B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000295901	ENST00000534317	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
5CDS-intron	ENST00000394431	ENST00000534317	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
5CDS-intron	ENST00000482510	ENST00000534317	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
5CDS-intron	ENST00000492933	ENST00000534317	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000295901	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000295901	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000394431	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000394431	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000482510	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000482510	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000492933	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+
In-frame	ENST00000492933	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295901	PSMD6	chr3	64004275	-	ENST00000282096	PDE3B	chr11	14856616	+	3155	967	1075	2010	311
ENST00000295901	PSMD6	chr3	64004275	-	ENST00000455098	PDE3B	chr11	14856616	+	2245	967	1075	2010	311
ENST00000492933	PSMD6	chr3	64004275	-	ENST00000282096	PDE3B	chr11	14856616	+	3226	1038	26	1057	343
ENST00000492933	PSMD6	chr3	64004275	-	ENST00000455098	PDE3B	chr11	14856616	+	2316	1038	26	1057	343
ENST00000394431	PSMD6	chr3	64004275	-	ENST00000282096	PDE3B	chr11	14856616	+	3047	859	967	1902	311
ENST00000394431	PSMD6	chr3	64004275	-	ENST00000455098	PDE3B	chr11	14856616	+	2137	859	967	1902	311
ENST00000482510	PSMD6	chr3	64004275	-	ENST00000282096	PDE3B	chr11	14856616	+	2936	748	856	1791	311
ENST00000482510	PSMD6	chr3	64004275	-	ENST00000455098	PDE3B	chr11	14856616	+	2026	748	856	1791	311

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295901	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000311924	0.99968815
ENST00000295901	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000617316	0.9993826
ENST00000492933	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000557703	0.9994423
ENST00000492933	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.001242685	0.99875736
ENST00000394431	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000279658	0.9997203
ENST00000394431	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000558157	0.9994418
ENST00000482510	ENST00000282096	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000302167	0.9996978
ENST00000482510	ENST00000455098	PSMD6	chr3	64004275	-	PDE3B	chr11	14856616	+	0.000619249	0.9993807

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Fusion Genomic Features for PSMD6-PDE3B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSMD6-PDE3B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:64004275/chr11:14856616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

1077_1080

1113.0

Compositional bias

Note=Poly-Glu

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

651_1079

1113.0

Domain

PDEase

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

117_137

1113.0

Transmembrane

Helical

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

152_172

1113.0

Transmembrane

Helical

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

192_212

1113.0

Transmembrane

Helical

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

220_240

1113.0

Transmembrane

Helical

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

247_267

1113.0

Transmembrane

Helical

Tgene

PDE3B

chr3:64004275

chr11:14856616

ENST00000282096

88_108

1113.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSMD6

chr3:64004275

chr11:14856616

ENST00000295901

193_361

275

390.0

Domain

PCI

Hgene

PSMD6

chr3:64004275

chr11:14856616

ENST00000394431

193_361

237

352.0

Domain

PCI

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Fusion Gene Sequence for PSMD6-PDE3B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69716_69716_1_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000295901_PDE3B_chr11_14856616_ENST00000282096_length(transcript)=3155nt_BP=967nt
AGCAGAGGACGCTGCCGGCGGAGACGGGACCGGAAGCCGGGCCGCAGGCGGCCGGGCGTATTCGCCGACTCCTCCCGCTTCCGCTGCCGC
AGCCGGTCGTAACCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGGTCTGCCCAAG
AACCCCGACTTGCGTATCGCGCAGCTGCGCTTCCTGCTCAGCCTGCCCGAGCACCGCGGAGACGCTGCCGTGCGCGACGAGCTGATGGCG
GCCGTCCGCGATAACAACATGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATG
AAGAAGGCAAATGAAGATGAGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCA
ATGATGGCAAAGGCCGAGTACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCC
CTGGGTCACCGATTGGATATTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAG
GCCAAAAGCTTAATAGAAGAAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGAT
TTCAAACAGGCAGCTGAACTCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACT
GTCTATGTCAGTATGATTGCCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTT
CCAGCAGTTCGGCAGTATCTGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAAC
AGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTC
TTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCT
AGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCT
TTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTAC
GGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAA
TGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGA
AGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCA
ACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTG
GTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAA
TCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAA
GGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCA
GGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGG
CAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCT
GCTGGCAGTTTCCCACTCCTATGCACTTTCACAGGAACTAGAAAACTATTCTTAAACCAAAAATACCATCCGTGTTGACCCATGTTGCAG
AGCCCTTACTTAAATCCTTCACTGGTGTATGAATACTTTGTCATAATGCTGCTTTGCTGGGTAGTGAGCTCTTATTTTTCACTGGGGGTC
AGCTATAACTAAAAACTCAAGTGACATATTTCAGTTACCAAAGTGGCCAGGAACTTTTTGCTTTTATGAAAATAGATTCATATTGTATTT
CCCAGTGTGTCTTTTATGTCTTTGAATGTTTTGGAGAAAAGTCTATGCCTGTCTAAAAATGAATCCAGTGTTGCCTTTCTGAGGGATTTC
TGCTCAATGCAATACACTGTTCAGTGCTATTCTCCCAGCTAGGTTTATCCATGAAGGACTGAGTGACCTTTGTTGTATTTAACAAAATCC
AGGTGCATCAATTTCTGATGCTTTTTACTATTGTGTATTATCTACTATGTGTGTTTTATTTCTGCTGAGAGTATTCAGGTTTGCCATGGA
CATCAGAAGTTTGAATTCCAGTCTTATCTTATGTTCCATGGCTGAATTTTAAAGCTGTTTAGGTTTAACAATGAAGGGATTTATTCTTTA
GTCAAAATTGTTGTTTTTACTCTAGCTCAGGATTCGTATTTTTAAAGATTTAGTTAATATGAACACAGCACAGATTTGTTAGAAGAAAAA
AAATTTGCTGTAATACCAAAACTAACCTCATCAAAGATACAGAAAAAAAGAAATATAGTGAGCCCTAAAGGACACATACATTGAATAAAT
AATTGGAACATGTGGTTATCTTTAGATCCACATCTTAGCTGTCATTTGTTCACTCTAAAACTGATGTTCATCTTTCTGTTAATTTCCCTC
TGCCTAAAGACTACATGACAGAAATGACCTATCACTACTTATTATTTCTGAAGCCTAACTGCAAGACTGATTTCTGAGAACAAGTAAAGA

>69716_69716_1_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000295901_PDE3B_chr11_14856616_ENST00000282096_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_2_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000295901_PDE3B_chr11_14856616_ENST00000455098_length(transcript)=2245nt_BP=967nt
AGCAGAGGACGCTGCCGGCGGAGACGGGACCGGAAGCCGGGCCGCAGGCGGCCGGGCGTATTCGCCGACTCCTCCCGCTTCCGCTGCCGC
AGCCGGTCGTAACCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGGTCTGCCCAAG
AACCCCGACTTGCGTATCGCGCAGCTGCGCTTCCTGCTCAGCCTGCCCGAGCACCGCGGAGACGCTGCCGTGCGCGACGAGCTGATGGCG
GCCGTCCGCGATAACAACATGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATG
AAGAAGGCAAATGAAGATGAGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCA
ATGATGGCAAAGGCCGAGTACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCC
CTGGGTCACCGATTGGATATTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAG
GCCAAAAGCTTAATAGAAGAAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGAT
TTCAAACAGGCAGCTGAACTCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACT
GTCTATGTCAGTATGATTGCCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTT
CCAGCAGTTCGGCAGTATCTGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAAC
AGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTC
TTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCT
AGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCT
TTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTAC
GGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAA
TGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGA
AGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCA
ACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTG
GTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAA
TCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAA
GGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCA
GGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGG
CAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCT

>69716_69716_2_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000295901_PDE3B_chr11_14856616_ENST00000455098_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_3_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000394431_PDE3B_chr11_14856616_ENST00000282096_length(transcript)=3047nt_BP=859nt
TAGATAGGGGTTTTCATTTAGGCCTTGCGACATGGCTGTTACATGACCTTGGTTGGTCTGTTTCCCTAACCTCTTTGTGCCTCATTTGTC
TTACCTACTAAATAGGCTAATAGTACTACCTCGCAGCATGAAGATGATTTTAATAAGATGAATGAGAGTAACGACTCGACAAACTATGAC
ATGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGAT
GAGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAG
TACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGAT
ATTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAA
GAAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAA
CTCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATT
GCCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTAT
CTGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAAT
TAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATT
AGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCC
TCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAA
CTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTT
TGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATG
CCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATT
TTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGA
ATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGA
TAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACC
AAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGA
AGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGA
TGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGT
GTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTC
CTATGCACTTTCACAGGAACTAGAAAACTATTCTTAAACCAAAAATACCATCCGTGTTGACCCATGTTGCAGAGCCCTTACTTAAATCCT
TCACTGGTGTATGAATACTTTGTCATAATGCTGCTTTGCTGGGTAGTGAGCTCTTATTTTTCACTGGGGGTCAGCTATAACTAAAAACTC
AAGTGACATATTTCAGTTACCAAAGTGGCCAGGAACTTTTTGCTTTTATGAAAATAGATTCATATTGTATTTCCCAGTGTGTCTTTTATG
TCTTTGAATGTTTTGGAGAAAAGTCTATGCCTGTCTAAAAATGAATCCAGTGTTGCCTTTCTGAGGGATTTCTGCTCAATGCAATACACT
GTTCAGTGCTATTCTCCCAGCTAGGTTTATCCATGAAGGACTGAGTGACCTTTGTTGTATTTAACAAAATCCAGGTGCATCAATTTCTGA
TGCTTTTTACTATTGTGTATTATCTACTATGTGTGTTTTATTTCTGCTGAGAGTATTCAGGTTTGCCATGGACATCAGAAGTTTGAATTC
CAGTCTTATCTTATGTTCCATGGCTGAATTTTAAAGCTGTTTAGGTTTAACAATGAAGGGATTTATTCTTTAGTCAAAATTGTTGTTTTT
ACTCTAGCTCAGGATTCGTATTTTTAAAGATTTAGTTAATATGAACACAGCACAGATTTGTTAGAAGAAAAAAAATTTGCTGTAATACCA
AAACTAACCTCATCAAAGATACAGAAAAAAAGAAATATAGTGAGCCCTAAAGGACACATACATTGAATAAATAATTGGAACATGTGGTTA
TCTTTAGATCCACATCTTAGCTGTCATTTGTTCACTCTAAAACTGATGTTCATCTTTCTGTTAATTTCCCTCTGCCTAAAGACTACATGA

>69716_69716_3_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000394431_PDE3B_chr11_14856616_ENST00000282096_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_4_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000394431_PDE3B_chr11_14856616_ENST00000455098_length(transcript)=2137nt_BP=859nt
TAGATAGGGGTTTTCATTTAGGCCTTGCGACATGGCTGTTACATGACCTTGGTTGGTCTGTTTCCCTAACCTCTTTGTGCCTCATTTGTC
TTACCTACTAAATAGGCTAATAGTACTACCTCGCAGCATGAAGATGATTTTAATAAGATGAATGAGAGTAACGACTCGACAAACTATGAC
ATGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGAT
GAGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAG
TACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGAT
ATTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAA
GAAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAA
CTCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATT
GCCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTAT
CTGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAAT
TAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATT
AGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCC
TCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAA
CTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTT
TGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATG
CCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATT
TTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGA
ATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGA
TAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACC
AAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGA
AGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGA
TGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGT
GTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTC

>69716_69716_4_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000394431_PDE3B_chr11_14856616_ENST00000455098_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_5_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000482510_PDE3B_chr11_14856616_ENST00000282096_length(transcript)=2936nt_BP=748nt
CCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGACATGGCTCCTTACTATGAAGCC
TTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGATGAGTTGAAGCGTTTGGATGAG
GAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAGTACCTCTGCCGGATAGGTGAC
AAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGATATTGTATTCTATCTCCTTAGG
ATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAAGAAGGAGGAGACTGGGACAGG
AGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAACTCTTCCTTGACACTGTTTCA
ACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATTGCCTTAGAAAGACCAGATCTC
AGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTATCTGTTTTCACTCTATGAATGC
CGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTA
TATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGT
GGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGA
CAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCA
TGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAA
TGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGC
AGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGA
AGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGT
GGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGA
TGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCG
AATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGG
GAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTT
TGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAAC
TGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCCTATGCACTTTCACAGGAACT
AGAAAACTATTCTTAAACCAAAAATACCATCCGTGTTGACCCATGTTGCAGAGCCCTTACTTAAATCCTTCACTGGTGTATGAATACTTT
GTCATAATGCTGCTTTGCTGGGTAGTGAGCTCTTATTTTTCACTGGGGGTCAGCTATAACTAAAAACTCAAGTGACATATTTCAGTTACC
AAAGTGGCCAGGAACTTTTTGCTTTTATGAAAATAGATTCATATTGTATTTCCCAGTGTGTCTTTTATGTCTTTGAATGTTTTGGAGAAA
AGTCTATGCCTGTCTAAAAATGAATCCAGTGTTGCCTTTCTGAGGGATTTCTGCTCAATGCAATACACTGTTCAGTGCTATTCTCCCAGC
TAGGTTTATCCATGAAGGACTGAGTGACCTTTGTTGTATTTAACAAAATCCAGGTGCATCAATTTCTGATGCTTTTTACTATTGTGTATT
ATCTACTATGTGTGTTTTATTTCTGCTGAGAGTATTCAGGTTTGCCATGGACATCAGAAGTTTGAATTCCAGTCTTATCTTATGTTCCAT
GGCTGAATTTTAAAGCTGTTTAGGTTTAACAATGAAGGGATTTATTCTTTAGTCAAAATTGTTGTTTTTACTCTAGCTCAGGATTCGTAT
TTTTAAAGATTTAGTTAATATGAACACAGCACAGATTTGTTAGAAGAAAAAAAATTTGCTGTAATACCAAAACTAACCTCATCAAAGATA
CAGAAAAAAAGAAATATAGTGAGCCCTAAAGGACACATACATTGAATAAATAATTGGAACATGTGGTTATCTTTAGATCCACATCTTAGC
TGTCATTTGTTCACTCTAAAACTGATGTTCATCTTTCTGTTAATTTCCCTCTGCCTAAAGACTACATGACAGAAATGACCTATCACTACT

>69716_69716_5_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000482510_PDE3B_chr11_14856616_ENST00000282096_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_6_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000482510_PDE3B_chr11_14856616_ENST00000455098_length(transcript)=2026nt_BP=748nt
CCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGACATGGCTCCTTACTATGAAGCC
TTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGATGAGTTGAAGCGTTTGGATGAG
GAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAGTACCTCTGCCGGATAGGTGAC
AAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGATATTGTATTCTATCTCCTTAGG
ATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAAGAAGGAGGAGACTGGGACAGG
AGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAACTCTTCCTTGACACTGTTTCA
ACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATTGCCTTAGAAAGACCAGATCTC
AGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTATCTGTTTTCACTCTATGAATGC
CGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTA
TATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGT
GGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGA
CAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCA
TGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAA
TGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGC
AGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGA
AGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGT
GGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGA
TGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCG
AATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGG
GAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTT
TGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAAC
TGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCCTATGCACTTTCACAGGAACT

>69716_69716_6_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000482510_PDE3B_chr11_14856616_ENST00000455098_length(amino acids)=311AA_BP=
MSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL
ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS
PQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKI

--------------------------------------------------------------
>69716_69716_7_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000492933_PDE3B_chr11_14856616_ENST00000282096_length(transcript)=3226nt_BP=1038nt
GCAGCCGGTCGTAACCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGGTCTGCCCA
AGAACCCCGACTTGCGTATCGCGCAGCTGCGCTTCCTGCTCAGCCTGCCCGAGCACCGCGGAGACGCTGCCGTGCGCGACGAGCTGATGG
CGGCCGTCCGCGATAACAACTTTTGGAACAGAATCCGGCAAGAGCAAACCGAGGATTGCCCTCCCTCCAGCCCTAGTAGAGGTTGGCATT
GCCAGGATTGGCCGTCACGCAAACCTCCCACCAGCATACGTTTATGTTTTGCCAAGCCGATTATTAAGCGCCATCGCATGCCTTCCTACA
TGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGATG
AGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAGT
ACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGATA
TTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAAG
AAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAAC
TCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATTG
CCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTATC
TGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATT
AACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTA
GAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCT
CAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAAC
TTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTT
GATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGC
CAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTT
TATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAA
TCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGAT
AATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCA
AGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAA
GAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGAT
GAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTG
TTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCC
TATGCACTTTCACAGGAACTAGAAAACTATTCTTAAACCAAAAATACCATCCGTGTTGACCCATGTTGCAGAGCCCTTACTTAAATCCTT
CACTGGTGTATGAATACTTTGTCATAATGCTGCTTTGCTGGGTAGTGAGCTCTTATTTTTCACTGGGGGTCAGCTATAACTAAAAACTCA
AGTGACATATTTCAGTTACCAAAGTGGCCAGGAACTTTTTGCTTTTATGAAAATAGATTCATATTGTATTTCCCAGTGTGTCTTTTATGT
CTTTGAATGTTTTGGAGAAAAGTCTATGCCTGTCTAAAAATGAATCCAGTGTTGCCTTTCTGAGGGATTTCTGCTCAATGCAATACACTG
TTCAGTGCTATTCTCCCAGCTAGGTTTATCCATGAAGGACTGAGTGACCTTTGTTGTATTTAACAAAATCCAGGTGCATCAATTTCTGAT
GCTTTTTACTATTGTGTATTATCTACTATGTGTGTTTTATTTCTGCTGAGAGTATTCAGGTTTGCCATGGACATCAGAAGTTTGAATTCC
AGTCTTATCTTATGTTCCATGGCTGAATTTTAAAGCTGTTTAGGTTTAACAATGAAGGGATTTATTCTTTAGTCAAAATTGTTGTTTTTA
CTCTAGCTCAGGATTCGTATTTTTAAAGATTTAGTTAATATGAACACAGCACAGATTTGTTAGAAGAAAAAAAATTTGCTGTAATACCAA
AACTAACCTCATCAAAGATACAGAAAAAAAGAAATATAGTGAGCCCTAAAGGACACATACATTGAATAAATAATTGGAACATGTGGTTAT
CTTTAGATCCACATCTTAGCTGTCATTTGTTCACTCTAAAACTGATGTTCATCTTTCTGTTAATTTCCCTCTGCCTAAAGACTACATGAC

>69716_69716_7_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000492933_PDE3B_chr11_14856616_ENST00000282096_length(amino acids)=343AA_BP=
MSAAVPFAAMPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNFWNRIRQEQTEDCPPSSPSRGWHCQDWPSRKP
PTSIRLCFAKPIIKRHRMPSYMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKE
GALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTF

--------------------------------------------------------------
>69716_69716_8_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000492933_PDE3B_chr11_14856616_ENST00000455098_length(transcript)=2316nt_BP=1038nt
GCAGCCGGTCGTAACCAAGTTGTGTCCTGTCAGCCGCTGTCCCCTTCGCCGCGATGCCGCTGGAGAACCTGGAGGAGGAGGGTCTGCCCA
AGAACCCCGACTTGCGTATCGCGCAGCTGCGCTTCCTGCTCAGCCTGCCCGAGCACCGCGGAGACGCTGCCGTGCGCGACGAGCTGATGG
CGGCCGTCCGCGATAACAACTTTTGGAACAGAATCCGGCAAGAGCAAACCGAGGATTGCCCTCCCTCCAGCCCTAGTAGAGGTTGGCATT
GCCAGGATTGGCCGTCACGCAAACCTCCCACCAGCATACGTTTATGTTTTGCCAAGCCGATTATTAAGCGCCATCGCATGCCTTCCTACA
TGGCTCCTTACTATGAAGCCTTGTGCAAATCCCTCGACTGGCAGATAGACGTGGACCTACTCAATAAAATGAAGAAGGCAAATGAAGATG
AGTTGAAGCGTTTGGATGAGGAGCTGGAAGATGCAGAGAAGAATCTAGGAGAGAGCGAAATTCGCGATGCAATGATGGCAAAGGCCGAGT
ACCTCTGCCGGATAGGTGACAAAGAGGGAGCTCTGACAGCCTTTCGCAAGACATATGACAAAACTGTGGCCCTGGGTCACCGATTGGATA
TTGTATTCTATCTCCTTAGGATTGGCTTATTTTATATGGATAATGATCTCATCACACGAAACACAGAAAAGGCCAAAAGCTTAATAGAAG
AAGGAGGAGACTGGGACAGGAGAAACCGCCTAAAAGTGTATCAGGGTCTTTATTGTGTGGCTATTCGTGATTTCAAACAGGCAGCTGAAC
TCTTCCTTGACACTGTTTCAACATTTACATCCTATGAACTCATGGATTATAAAACATTTGTGACTTATACTGTCTATGTCAGTATGATTG
CCTTAGAAAGACCAGATCTCAGGGAAAAGGTCATTAAAGGAGCAGAGATTCTTGAAGTGTTGCACAGTCTTCCAGCAGTTCGGCAGTATC
TGTTTTCACTCTATGAATGCCGTTACTCTGTTTTCTTCCAATCATTAGGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATT
AACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTA
GAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCT
CAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAAC
TTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTT
GATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGC
CAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTT
TATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAA
TCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGAT
AATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCA
AGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAA
GAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGAT
GAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAGAAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTG
TTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTTAATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCC

>69716_69716_8_PSMD6-PDE3B_PSMD6_chr3_64004275_ENST00000492933_PDE3B_chr11_14856616_ENST00000455098_length(amino acids)=343AA_BP=
MSAAVPFAAMPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNFWNRIRQEQTEDCPPSSPSRGWHCQDWPSRKP
PTSIRLCFAKPIIKRHRMPSYMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKE
GALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTF

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Fusion Gene PPI Analysis for PSMD6-PDE3B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	PDE3B	chr3:64004275	chr11:14856616	ENST00000282096		0	16	436_460	0	1113.0	PIK3R6
Tgene	PDE3B	chr3:64004275	chr11:14856616	ENST00000282096		0	16	1_25	0	1113.0	RAPGEF3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PSMD6-PDE3B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PSMD6-PDE3B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source