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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PSME3-TM9SF2 (FusionGDB2 ID:69753)

Fusion Gene Summary for PSME3-TM9SF2

Fusion gene summary

Fusion gene information	Fusion gene name: PSME3-TM9SF2
	Fusion gene ID: 69753
		Hgene	Tgene
	Gene symbol	PSME3	TM9SF2
	Gene ID	10197	9375
	Gene name	proteasome activator subunit 3	transmembrane 9 superfamily member 2
	Synonyms	HEL-S-283\|Ki\|PA28-gamma\|PA28G\|PA28gamma\|REG-GAMMA	P76
	Cytomap	17q21.31	13q32.3
	Type of gene	protein-coding	protein-coding
	Description	proteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein L	transmembrane 9 superfamily member 276 kDa membrane proteindinucleotide oxidase disulfide thiol exchanger 3 superfamily member 2epididymis secretory sperm binding proteintransmembrane protein 9 superfamily member 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000541124, ENST00000293362, ENST00000441946, ENST00000545225, ENST00000590720, ENST00000592169, ENST00000592578,	ENST00000376387, ENST00000463709,
Fusion gene scores	* DoF score	7 X 6 X 4=168	9 X 8 X 3=216
	# samples	7	9
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PSME3 [Title/Abstract] AND TM9SF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PSME3(40991397)-TM9SF2(100214945), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PSME3	GO:0061136	regulation of proteasomal protein catabolic process	18309296
Hgene	PSME3	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	18309296

Fusion gene breakpoints across PSME3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TM9SF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-V1-A9ZR-01A	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+

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Fusion Gene ORF analysis for PSME3-TM9SF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000541124	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
3UTR-intron	ENST00000541124	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
5CDS-intron	ENST00000293362	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
5CDS-intron	ENST00000441946	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
5CDS-intron	ENST00000545225	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
5CDS-intron	ENST00000590720	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
5CDS-intron	ENST00000592169	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
In-frame	ENST00000293362	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
In-frame	ENST00000441946	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
In-frame	ENST00000545225	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
In-frame	ENST00000590720	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
In-frame	ENST00000592169	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
intron-3CDS	ENST00000592578	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+
intron-intron	ENST00000592578	ENST00000463709	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000545225

PSME3

chr17

40991397

ENST00000376387

TM9SF2

chr13

100214945

2656

1340

740

1396

218

ENST00000590720

PSME3

chr17

40991397

ENST00000376387

TM9SF2

chr13

100214945

2233

917

233

973

246

ENST00000441946

PSME3

chr17

40991397

ENST00000376387

TM9SF2

chr13

100214945

2541

1225

493

1281

262

ENST00000293362

PSME3

chr17

40991397

ENST00000376387

TM9SF2

chr13

100214945

2200

884

161

940

259

ENST00000592169

PSME3

chr17

40991397

ENST00000376387

TM9SF2

chr13

100214945

1968

652

136

708

190

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000545225	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+	0.001348016	0.99865204
ENST00000590720	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+	0.000536689	0.9994634
ENST00000441946	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+	0.002271839	0.99772817
ENST00000293362	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+	0.000551459	0.9994485
ENST00000592169	ENST00000376387	PSME3	chr17	40991397	+	TM9SF2	chr13	100214945	+	0.00045637	0.9995436

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Fusion Genomic Features for PSME3-TM9SF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PSME3	chr17	40991397	+	TM9SF2	chr13	100214944	+	7.94E-07	0.99999917
PSME3	chr17	40991397	+	TM9SF2	chr13	100214944	+	7.94E-07	0.99999917

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSME3-TM9SF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40991397/chr13:100214945)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

653_663

641

664.0

Topological domain

Cytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

29_300

641

664.0

Topological domain

Lumenal

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

322_374

641

664.0

Topological domain

Cytoplasmic

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

396_398

641

664.0

Topological domain

Lumenal

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

420_437

641

664.0

Topological domain

Cytoplasmic

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

459_466

641

664.0

Topological domain

Lumenal

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

488_522

641

664.0

Topological domain

Cytoplasmic

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

544_554

641

664.0

Topological domain

Lumenal

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

576_591

641

664.0

Topological domain

Cytoplasmic

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

613_631

641

664.0

Topological domain

Lumenal

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

301_321

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

375_395

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

399_419

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

438_458

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

467_487

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

523_543

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

555_575

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

592_612

641

664.0

Transmembrane

Helical

Tgene

TM9SF2

chr17:40991397

chr13:100214945

ENST00000376387

632_652

641

664.0

Transmembrane

Helical

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Fusion Gene Sequence for PSME3-TM9SF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69753_69753_1_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000293362_TM9SF2_chr13_100214945_ENST00000376387_length(transcript)=2200nt_BP=884nt
GGGCGGACGGCACAGAGGGAGGGAGCGAGCGAGCAGTGAGTAAGCCAGCAAGGGCGGTCGGGTCCCGAGGTCAGCCGAGATTTCTCAGGT
CCCTCCGGCCCCCTCCCTGGAGTCCACAGCGCCTCCGGTGTCCAGAGGATCGGACACGGCCCGGCCCGGCCATGGCCTCGTTGCTGAAGG
TGGATCAGGAAGTGAAGCTCAAGGTTGATTCTTTCAGGGAGCGGATCACAAGTGAGGCAGAAGACTTGGTGGCAAATTTTTTCCCAAAGA
AGTTATTAGAACTTGATAGTTTTCTGAAGGAACCAATCTTAAACATCCATGACCTAACTCAGATCCACTCTGACATGAATCTCCCAGTCC
CTGACCCCATTCTTCTCACCAATAGCCATGATGGACTGGATGGTCCCACTTATAAGAAGCGAAGGTTGGATGAGTGTGAAGAAGCCTTCC
AAGGAACCAAGGTGTTTGTGATGCCCAATGGGATGCTGAAAAGCAACCAGCAGCTGGTGGACATTATTGAGAAAGTGAAACCTGAGATCC
GGCTGTTGATTGAGAAATGTAACACGCCTTCAGGCAAAGGTCCTCATATATGTTTTGACCTCCAGGTCAAAATGTGGGTACAGCTCCTGA
TTCCCAGGATAGAAGATGGAAACAACTTTGGGGTGTCCATTCAGGAGGAAACAGTTGCAGAGCTAAGAACTGTTGAGAGTGAAGCTGCAT
CTTATCTGGACCAGATTTCTAGATATTATATTACAAGAGCCAAATTGGTTTCTAAAATAGCTAAATATCCCCATGTGGAGGACTATCGCC
GCACCGTGACAGAGATTGATGAGAAAGAATATATCAGCCTTCGGCTCATCATATCAGAGCTGAGGAATCAATATGAACAATTGGCTTCTT
TGCATGCTTTTGGTTTGTTACCAAAATATACAGTGTGGTGAAGGTTGACTGAAGAAGTCCAGTGTGTCCAGTTAAAACAGAAATAAATTA
AACTCTTCATCAACAAAGACCTGTTTTTGTGACTGCCTTGAGTTTTATCAGAATTATTGGCCTAGTAATCCTTCAGAAACACCGTAATTC
TAAATAAACCTCTTCCCATACACCTTTCCCCCATAAGATGTGTCTTCAACACTATAAAGCATTTGTATTGTGATTTGATTAAGTATATAT
TTGGTTGTTCTCAATGAAGAGCAAATTTAAATATTATGTGCATTTGTAAATACAGTAGCTATAAAATTTTCCATACTTCTAATGGCAGAA
TAGAGGAGGCCATATTAAATAATACTGATGAAAGGCAGGACACTGCATTGTAAATAGGATTTTCTAGGCTCGGTAGGCAGAAAGAATTAT
TTTTCTTTGAAGGAAATAACTTTTTATCATGGTAATTTTGAAGGATGATTCCTATGATGTGTTCACCAGGGGAATGTGGCTTTTAAAGAA
AATCTTCTATTGGTTGTAACTGTTCATATCTTCTTACTTTTCTGTGTTGACTTCATTATTCCCATGGTATTGGCCTTTTAAACTATGTGC
CTCTGAGTCTTTCAATTTATAAATTTGTTATCTTAATAAATATTATAAAAATGTCTTCATTGCATCATTACCTATTATATATTCAAGGAG
GTTCTGTAAATACAGATCTATTTACCAAGGTGTTTTGAAATGATTTATACTATTTTATCAGATTTTACTGGATTTTGTTAATGTAACACT
TTCTGAGTTTTGATCTGAATGGAATTTCACTGTGTAAGGCATTGTCTAAAATGTTCACTGTGAGGCAGTAGAGGAGGTTGAAGTCATGCA
TATCTAGACAGATGAATTATCTGCAAGTACTTAAGGTGGAGCCTTACTACATTGTCATTAAGGAGTTTCTATTTTTGACTTGTTTTTCAA
AATACAGTGTTTTAAGTCAGGTTTTATTACCTGGACATTAGCAATCACTAGCAAGTCTTCATCTTTATGATTTCATTGTTTTAATTTAGA
TTTCACAAACAGTTTTACTTCTAAGAGTTAAGAAATGCACTGTCTTTCACATTCATCTGACTAATTGAAATCCATTTATGTAGAATATAG
GAATGGGGGGTGATTCTGAAGTATCGGTCTGCTTGTATCTGTGAGCATATTCATTTGTATTTTAGGGTCTCTCTGCTTGCTGCTTAGGAG

>69753_69753_1_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000293362_TM9SF2_chr13_100214945_ENST00000376387_length(amino acids)=259AA_BP=241
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLD
ECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRT

--------------------------------------------------------------
>69753_69753_2_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000441946_TM9SF2_chr13_100214945_ENST00000376387_length(transcript)=2541nt_BP=1225nt
GAAAGCCGGGAGGGCGAGCGAGAGAGCAAGCAGGCAGCAGGCTGCCGGCGGGCGGGCGGACGGCACAGAGGGAGGGAGCGAGCGAGCAGT
GAGTAAGCCAGCAAGGGCGGTCGGGTCCCGAGGTCAGCCGAGATTTCTCAGGTCCCTCCGGCCCCCTCCCTGGAGTCCACAGCGCCTCCG
GTGTCCAGAGGATCGGACACGGCCCGGCCCGGCCATGGCCTCGTTGCTGAAGGTGGATCAGGAAGTGAAGCTCAAGCTCTGAGCTTCCGC
TCGGCTCAGCCCAGCCCCCAACTCCCGGGGTCGGCTTCGCGGGAGAGGAAAATATAGGATGGCTTTCTGTACCGCGTCTGATGATGGAGA
GTCCCGGGGACACCTCCGCGGACACGTGTTGGACTCAGGGCTTTAGGCCCGTGACAGCTGACAGCTTCAGACACAGGAGGAAGGGAGGGA
AGGGGGAGGACAGAGGAGACAGGCAGGTGCTGTCCTCAAAGCCCTGCGTTCTTCTGAGATGGAAAAATGGATCCTCAAAAAAATAAAGTA
TTTGCAGTCTGGGGGCCTCTCAGCTTCTTATTACAGTTACAAGGTTGATTCTTTCAGGGAGCGGATCACAAGTGAGGCAGAAGACTTGGT
GGCAAATTTTTTCCCAAAGAAGTTATTAGAACTTGATAGTTTTCTGAAGGAACCAATCTTAAACATCCATGACCTAACTCAGATCCACTC
TGACATGAATCTCCCAGTCCCTGACCCCATTCTTCTCACCAATAGCCATGATGGACTGGATGGTCCCACTTATAAGAAGCGAAGGTTGGA
TGAGTGTGAAGAAGCCTTCCAAGGAACCAAGGTGTTTGTGATGCCCAATGGGATGCTGAAAAGCAACCAGCAGCTGGTGGACATTATTGA
GAAAGTGAAACCTGAGATCCGGCTGTTGATTGAGAAATGTAACACGGTCAAAATGTGGGTACAGCTCCTGATTCCCAGGATAGAAGATGG
AAACAACTTTGGGGTGTCCATTCAGGAGGAAACAGTTGCAGAGCTAAGAACTGTTGAGAGTGAAGCTGCATCTTATCTGGACCAGATTTC
TAGATATTATATTACAAGAGCCAAATTGGTTTCTAAAATAGCTAAATATCCCCATGTGGAGGACTATCGCCGCACCGTGACAGAGATTGA
TGAGAAAGAATATATCAGCCTTCGGCTCATCATATCAGAGCTGAGGAATCAATATGAACAATTGGCTTCTTTGCATGCTTTTGGTTTGTT
ACCAAAATATACAGTGTGGTGAAGGTTGACTGAAGAAGTCCAGTGTGTCCAGTTAAAACAGAAATAAATTAAACTCTTCATCAACAAAGA
CCTGTTTTTGTGACTGCCTTGAGTTTTATCAGAATTATTGGCCTAGTAATCCTTCAGAAACACCGTAATTCTAAATAAACCTCTTCCCAT
ACACCTTTCCCCCATAAGATGTGTCTTCAACACTATAAAGCATTTGTATTGTGATTTGATTAAGTATATATTTGGTTGTTCTCAATGAAG
AGCAAATTTAAATATTATGTGCATTTGTAAATACAGTAGCTATAAAATTTTCCATACTTCTAATGGCAGAATAGAGGAGGCCATATTAAA
TAATACTGATGAAAGGCAGGACACTGCATTGTAAATAGGATTTTCTAGGCTCGGTAGGCAGAAAGAATTATTTTTCTTTGAAGGAAATAA
CTTTTTATCATGGTAATTTTGAAGGATGATTCCTATGATGTGTTCACCAGGGGAATGTGGCTTTTAAAGAAAATCTTCTATTGGTTGTAA
CTGTTCATATCTTCTTACTTTTCTGTGTTGACTTCATTATTCCCATGGTATTGGCCTTTTAAACTATGTGCCTCTGAGTCTTTCAATTTA
TAAATTTGTTATCTTAATAAATATTATAAAAATGTCTTCATTGCATCATTACCTATTATATATTCAAGGAGGTTCTGTAAATACAGATCT
ATTTACCAAGGTGTTTTGAAATGATTTATACTATTTTATCAGATTTTACTGGATTTTGTTAATGTAACACTTTCTGAGTTTTGATCTGAA
TGGAATTTCACTGTGTAAGGCATTGTCTAAAATGTTCACTGTGAGGCAGTAGAGGAGGTTGAAGTCATGCATATCTAGACAGATGAATTA
TCTGCAAGTACTTAAGGTGGAGCCTTACTACATTGTCATTAAGGAGTTTCTATTTTTGACTTGTTTTTCAAAATACAGTGTTTTAAGTCA
GGTTTTATTACCTGGACATTAGCAATCACTAGCAAGTCTTCATCTTTATGATTTCATTGTTTTAATTTAGATTTCACAAACAGTTTTACT
TCTAAGAGTTAAGAAATGCACTGTCTTTCACATTCATCTGACTAATTGAAATCCATTTATGTAGAATATAGGAATGGGGGGTGATTCTGA
AGTATCGGTCTGCTTGTATCTGTGAGCATATTCATTTGTATTTTAGGGTCTCTCTGCTTGCTGCTTAGGAGAGCAAATCAGATACTGTCA

>69753_69753_2_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000441946_TM9SF2_chr13_100214945_ENST00000376387_length(amino acids)=262AA_BP=244
MRSSEMEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTN
SHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAE

--------------------------------------------------------------
>69753_69753_3_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000545225_TM9SF2_chr13_100214945_ENST00000376387_length(transcript)=2656nt_BP=1340nt
AAGTGTAGGAGCCAAGGCCGCAGAGAATGGGGAGGCTCCGCTATTCTCTAAATTCAGGGGGCGGCGGGCGCGGTGGCTCACGCCTGTAAT
CTCAGCACTTGGGGAGGCCGAGGAGGGCGGATCACGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACAGTGAAACCCCGTCTCTAC
TAAAAATACAAAAACTAGCCGGGCGTGGTGGGGCACGCCTATAATCCCAGCTTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCG
CTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGGGCCACTGCACTCCAGCCTGGGCGACAGGGCAAGGCTCCATCTCAGAACA
ACAACAGCAACAACAAAAGGCCGGGCATGGTGGCTCACGCTTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACAAGGCTGG
AGTGAAGCGGAACAAACAAACATGGCTCACTGCAGATTTGACTTCCTGGCTCAAGCAATCCTCTTGCTTCAACCTCCAGTGTAGCAGGGA
CCACAGCATGAAAGCCCCTTTAGGGGAGGTGACTGGAATCATCCCCAAAGAATTCTCACCTAGTCCTGGTGTGGCTGCTTCATAGTCCTG
CGTTTCTTCCTGCTTGGCTGTCCCTAACATCTCAGAAACGCATAGAGAAGTAACGGGCTTCTAGAGAGGTTGATTCTTTCAGGGAGCGGA
TCACAAGTGAGGCAGAAGACTTGGTGGCAAATTTTTTCCCAAAGAAGTTATTAGAACTTGATAGTTTTCTGAAGGAACCAATCTTAAACA
TCCATGACCTAACTCAGATCCACTCTGACATGAATCTCCCAGTCCCTGACCCCATTCTTCTCACCAATAGCCATGATGGACTGGATGGTC
CCACTTATAAGAAGCGAAGGTTGGATGAGTGTGAAGAAGCCTTCCAAGGAACCAAGGTGTTTGTGATGCCCAATGGGATGCTGAAAAGCA
ACCAGCAGCTGGTGGACATTATTGAGAAAGTGAAACCTGAGATCCGGCTGTTGATTGAGAAATGTAACACGGTCAAAATGTGGGTACAGC
TCCTGATTCCCAGGATAGAAGATGGAAACAACTTTGGGGTGTCCATTCAGGAGGAAACAGTTGCAGAGCTAAGAACTGTTGAGAGTGAAG
CTGCATCTTATCTGGACCAGATTTCTAGATATTATATTACAAGAGCCAAATTGGTTTCTAAAATAGCTAAATATCCCCATGTGGAGGACT
ATCGCCGCACCGTGACAGAGATTGATGAGAAAGAATATATCAGCCTTCGGCTCATCATATCAGAGCTGAGGAATCAATATGAACAATTGG
CTTCTTTGCATGCTTTTGGTTTGTTACCAAAATATACAGTGTGGTGAAGGTTGACTGAAGAAGTCCAGTGTGTCCAGTTAAAACAGAAAT
AAATTAAACTCTTCATCAACAAAGACCTGTTTTTGTGACTGCCTTGAGTTTTATCAGAATTATTGGCCTAGTAATCCTTCAGAAACACCG
TAATTCTAAATAAACCTCTTCCCATACACCTTTCCCCCATAAGATGTGTCTTCAACACTATAAAGCATTTGTATTGTGATTTGATTAAGT
ATATATTTGGTTGTTCTCAATGAAGAGCAAATTTAAATATTATGTGCATTTGTAAATACAGTAGCTATAAAATTTTCCATACTTCTAATG
GCAGAATAGAGGAGGCCATATTAAATAATACTGATGAAAGGCAGGACACTGCATTGTAAATAGGATTTTCTAGGCTCGGTAGGCAGAAAG
AATTATTTTTCTTTGAAGGAAATAACTTTTTATCATGGTAATTTTGAAGGATGATTCCTATGATGTGTTCACCAGGGGAATGTGGCTTTT
AAAGAAAATCTTCTATTGGTTGTAACTGTTCATATCTTCTTACTTTTCTGTGTTGACTTCATTATTCCCATGGTATTGGCCTTTTAAACT
ATGTGCCTCTGAGTCTTTCAATTTATAAATTTGTTATCTTAATAAATATTATAAAAATGTCTTCATTGCATCATTACCTATTATATATTC
AAGGAGGTTCTGTAAATACAGATCTATTTACCAAGGTGTTTTGAAATGATTTATACTATTTTATCAGATTTTACTGGATTTTGTTAATGT
AACACTTTCTGAGTTTTGATCTGAATGGAATTTCACTGTGTAAGGCATTGTCTAAAATGTTCACTGTGAGGCAGTAGAGGAGGTTGAAGT
CATGCATATCTAGACAGATGAATTATCTGCAAGTACTTAAGGTGGAGCCTTACTACATTGTCATTAAGGAGTTTCTATTTTTGACTTGTT
TTTCAAAATACAGTGTTTTAAGTCAGGTTTTATTACCTGGACATTAGCAATCACTAGCAAGTCTTCATCTTTATGATTTCATTGTTTTAA
TTTAGATTTCACAAACAGTTTTACTTCTAAGAGTTAAGAAATGCACTGTCTTTCACATTCATCTGACTAATTGAAATCCATTTATGTAGA
ATATAGGAATGGGGGGTGATTCTGAAGTATCGGTCTGCTTGTATCTGTGAGCATATTCATTTGTATTTTAGGGTCTCTCTGCTTGCTGCT

>69753_69753_3_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000545225_TM9SF2_chr13_100214945_ENST00000376387_length(amino acids)=218AA_BP=200
MVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDI
IEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTE

--------------------------------------------------------------
>69753_69753_4_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000590720_TM9SF2_chr13_100214945_ENST00000376387_length(transcript)=2233nt_BP=917nt
AGTTTCCGGCGTGAGCGGCGAAAGCCGGGAGGGCGAGCGAGAGAGCAAGCAGGCAGCAGGCTGCCGGCGGGCGGGCGGACGGCACAGAGG
GAGGGAGCGAGCGAGCAGTGAGTAAGCCAGCAAGGGCGGTCGGGTCCCGAGGTCAGCCGAGATTTCTCAGGTCCCTCCGGCCCCCTCCCT
GGAGTCCACAGCGCCTCCGGTGTCCAGAGGATCGGACACGGCCCGGCCCGGCCATGGCCTCGTTGCTGAAGGTGGATCAGGAAGTGAAGC
TCAAGGTTGATTCTTTCAGGGAGCGGATCACAAGTGAGGCAGAAGACTTGGTGGCAAATTTTTTCCCAAAGAAGTTATTAGAACTTGATA
GTTTTCTGAAGGAACCAATCTTAAACATCCATGACCTAACTCAGATCCACTCTGACATGAATCTCCCAGTCCCTGACCCCATTCTTCTCA
CCAATAGCCATGATGGACTGGATGGTCCCACTTATAAGAAGCGAAGGTTGGATGAGTGTGAAGAAGCCTTCCAAGGAACCAAGGTGTTTG
TGATGCCCAATGGGATGCTGAAAAGCAACCAGCAGCTGGTGGACATTATTGAGAAAGTGAAACCTGAGATCCGGCTGTTGATTGAGAAAT
GTAACACGGTCAAAATGTGGGTACAGCTCCTGATTCCCAGGATAGAAGATGGAAACAACTTTGGGGTGTCCATTCAGGAGGAAACAGTTG
CAGAGCTAAGAACTGTTGAGAGTGAAGCTGCATCTTATCTGGACCAGATTTCTAGATATTATATTACAAGAGCCAAATTGGTTTCTAAAA
TAGCTAAATATCCCCATGTGGAGGACTATCGCCGCACCGTGACAGAGATTGATGAGAAAGAATATATCAGCCTTCGGCTCATCATATCAG
AGCTGAGGAATCAATATGAACAATTGGCTTCTTTGCATGCTTTTGGTTTGTTACCAAAATATACAGTGTGGTGAAGGTTGACTGAAGAAG
TCCAGTGTGTCCAGTTAAAACAGAAATAAATTAAACTCTTCATCAACAAAGACCTGTTTTTGTGACTGCCTTGAGTTTTATCAGAATTAT
TGGCCTAGTAATCCTTCAGAAACACCGTAATTCTAAATAAACCTCTTCCCATACACCTTTCCCCCATAAGATGTGTCTTCAACACTATAA
AGCATTTGTATTGTGATTTGATTAAGTATATATTTGGTTGTTCTCAATGAAGAGCAAATTTAAATATTATGTGCATTTGTAAATACAGTA
GCTATAAAATTTTCCATACTTCTAATGGCAGAATAGAGGAGGCCATATTAAATAATACTGATGAAAGGCAGGACACTGCATTGTAAATAG
GATTTTCTAGGCTCGGTAGGCAGAAAGAATTATTTTTCTTTGAAGGAAATAACTTTTTATCATGGTAATTTTGAAGGATGATTCCTATGA
TGTGTTCACCAGGGGAATGTGGCTTTTAAAGAAAATCTTCTATTGGTTGTAACTGTTCATATCTTCTTACTTTTCTGTGTTGACTTCATT
ATTCCCATGGTATTGGCCTTTTAAACTATGTGCCTCTGAGTCTTTCAATTTATAAATTTGTTATCTTAATAAATATTATAAAAATGTCTT
CATTGCATCATTACCTATTATATATTCAAGGAGGTTCTGTAAATACAGATCTATTTACCAAGGTGTTTTGAAATGATTTATACTATTTTA
TCAGATTTTACTGGATTTTGTTAATGTAACACTTTCTGAGTTTTGATCTGAATGGAATTTCACTGTGTAAGGCATTGTCTAAAATGTTCA
CTGTGAGGCAGTAGAGGAGGTTGAAGTCATGCATATCTAGACAGATGAATTATCTGCAAGTACTTAAGGTGGAGCCTTACTACATTGTCA
TTAAGGAGTTTCTATTTTTGACTTGTTTTTCAAAATACAGTGTTTTAAGTCAGGTTTTATTACCTGGACATTAGCAATCACTAGCAAGTC
TTCATCTTTATGATTTCATTGTTTTAATTTAGATTTCACAAACAGTTTTACTTCTAAGAGTTAAGAAATGCACTGTCTTTCACATTCATC
TGACTAATTGAAATCCATTTATGTAGAATATAGGAATGGGGGGTGATTCTGAAGTATCGGTCTGCTTGTATCTGTGAGCATATTCATTTG

>69753_69753_4_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000590720_TM9SF2_chr13_100214945_ENST00000376387_length(amino acids)=246AA_BP=228
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLD
ECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS

--------------------------------------------------------------
>69753_69753_5_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000592169_TM9SF2_chr13_100214945_ENST00000376387_length(transcript)=1968nt_BP=652nt
CGAGCGAGCAGTGAGTAAGCCAGCAAGGGCGGTCGGGTCCCGAGGTCAGCCGAGATTTCTCAGGTCCCTCCGGCCCCCTCCCTGGAGTCC
ACAGCGCCTCCGGTGTCCAGAGGATCGGACACGGCCCGGCCCGGCCATGGCCTCGTTGCTGAAGGTGGATCAGGAAGTGAAGCTCAAGGT
TGATTCTTTCAGGGAGCGGATCACAAGTGAGCCCACTTATAAGAAGCGAAGGTTGGATGAGTGTGAAGAAGCCTTCCAAGGAACCAAGGT
GTTTGTGATGCCCAATGGGATGCTGAAAAGCAACCAGCAGCTGGTGGACATTATTGAGAAAGTGAAACCTGAGATCCGGCTGTTGATTGA
GAAATGTAACACGGTCAAAATGTGGGTACAGCTCCTGATTCCCAGGATAGAAGATGGAAACAACTTTGGGGTGTCCATTCAGGAGGAAAC
AGTTGCAGAGCTAAGAACTGTTGAGAGTGAAGCTGCATCTTATCTGGACCAGATTTCTAGATATTATATTACAAGAGCCAAATTGGTTTC
TAAAATAGCTAAATATCCCCATGTGGAGGACTATCGCCGCACCGTGACAGAGATTGATGAGAAAGAATATATCAGCCTTCGGCTCATCAT
ATCAGAGCTGAGGAATCAATATGAACAATTGGCTTCTTTGCATGCTTTTGGTTTGTTACCAAAATATACAGTGTGGTGAAGGTTGACTGA
AGAAGTCCAGTGTGTCCAGTTAAAACAGAAATAAATTAAACTCTTCATCAACAAAGACCTGTTTTTGTGACTGCCTTGAGTTTTATCAGA
ATTATTGGCCTAGTAATCCTTCAGAAACACCGTAATTCTAAATAAACCTCTTCCCATACACCTTTCCCCCATAAGATGTGTCTTCAACAC
TATAAAGCATTTGTATTGTGATTTGATTAAGTATATATTTGGTTGTTCTCAATGAAGAGCAAATTTAAATATTATGTGCATTTGTAAATA
CAGTAGCTATAAAATTTTCCATACTTCTAATGGCAGAATAGAGGAGGCCATATTAAATAATACTGATGAAAGGCAGGACACTGCATTGTA
AATAGGATTTTCTAGGCTCGGTAGGCAGAAAGAATTATTTTTCTTTGAAGGAAATAACTTTTTATCATGGTAATTTTGAAGGATGATTCC
TATGATGTGTTCACCAGGGGAATGTGGCTTTTAAAGAAAATCTTCTATTGGTTGTAACTGTTCATATCTTCTTACTTTTCTGTGTTGACT
TCATTATTCCCATGGTATTGGCCTTTTAAACTATGTGCCTCTGAGTCTTTCAATTTATAAATTTGTTATCTTAATAAATATTATAAAAAT
GTCTTCATTGCATCATTACCTATTATATATTCAAGGAGGTTCTGTAAATACAGATCTATTTACCAAGGTGTTTTGAAATGATTTATACTA
TTTTATCAGATTTTACTGGATTTTGTTAATGTAACACTTTCTGAGTTTTGATCTGAATGGAATTTCACTGTGTAAGGCATTGTCTAAAAT
GTTCACTGTGAGGCAGTAGAGGAGGTTGAAGTCATGCATATCTAGACAGATGAATTATCTGCAAGTACTTAAGGTGGAGCCTTACTACAT
TGTCATTAAGGAGTTTCTATTTTTGACTTGTTTTTCAAAATACAGTGTTTTAAGTCAGGTTTTATTACCTGGACATTAGCAATCACTAGC
AAGTCTTCATCTTTATGATTTCATTGTTTTAATTTAGATTTCACAAACAGTTTTACTTCTAAGAGTTAAGAAATGCACTGTCTTTCACAT
TCATCTGACTAATTGAAATCCATTTATGTAGAATATAGGAATGGGGGGTGATTCTGAAGTATCGGTCTGCTTGTATCTGTGAGCATATTC

>69753_69753_5_PSME3-TM9SF2_PSME3_chr17_40991397_ENST00000592169_TM9SF2_chr13_100214945_ENST00000376387_length(amino acids)=190AA_BP=172
MASLLKVDQEVKLKVDSFRERITSEPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPR
IEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYEQLASLHA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PSME3-TM9SF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PSME3-TM9SF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PSME3-TM9SF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source